Details of the Drug Pharmacogenomic Perturbation Atlas

Flunisolide Drug Info

Aerobid; Aerospan; Bronalide; Flunisolida; Flunisolidum; Lunis; Nasalide; Nasarel; Nisolid; Rhinalar; Rhinolar; Soluzione; Synaclyn; Syntaris; Aerobid M; Aerospan HFA; Flunisolide HFA; Flunisolide [INN]; Flunisolide [anhydrous]; Flunisolide anhydrous; F0437; RS 3999; AeroBid (TN); Flunisolida [INN-Spanish]; Flunisolide (anhydrous); Flunisolidum [INN-Latin]; Nasalide (TN); Nasarel (TN); RS-3999; AeroBid, Nasalide, Nasarel,Flunisolide; Pregna-1,4-diene-3,20-dione, 6-alpha-fluoro-11-beta,16-alpha,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone; Pregna-1,4-diene-3,20-dione, 6-alpha-fluoro-11-beta,16-alpha,17,21-tetrahydroxy-,cyclic 16,17-acetal with acetone; 6 alpha-fluoro-11 beta,16 alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16, 17-acetal with acetone; 6 alpha-fluorodihydroxy-16 alpha,17 alpha-isopropylidenedioxy-1,4-pregnadiene-3,20-dione; 6-Fluoro-11,21-dihydroxy-16,17-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione; 6alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16, 17-acetal with acetone; 6alpha-fluoro-11beta,21-dihydroxy-16alpha,17alpha-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione

Therapeutic Class

Antiasthmatic Agents

Cross-matching ID

PubChem CID

82153

ChEBI ID

CHEMBL1512

CAS Number

CAS 3385-03-3

TTD Drug ID

D0FM2P

INTEDE Drug ID

DR0710

ACDINA Drug ID

D01088

General Information of Drug (ID: DMZSWQC)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Ribosome	2.40	0.00e+0	113/158 (71.52%)	MRPL17;MRPL23;RPS25;...
Ribosome biogenesis in eukaryotes	1.77	4.81e-2	52/108 (48.15%)	NAT10;NVL;RBM28;...
Renin secretion	-1.71	4.81e-2	61/69 (88.41%)	PTGER4;ITPR1;GNAI2;...
Endocrine and other factor-regulated calcium reabsorpti...	-1.74	3.45e-2	49/53 (92.45%)	FXYD2;AP2B1;CLTB;...
Inflammatory mediator regulation of TRP channels	-1.75	3.83e-2	82/98 (83.67%)	PIK3R2;IGF1;PTGER4;...
Salivary secretion	-1.76	3.85e-2	76/93 (81.72%)	PLCB2;PRB1;GUCY1B1;...
Synaptic vesicle cycle	-1.77	4.05e-2	63/78 (80.77%)	SYT1;SLC17A6;STX2;...
Porphyrin and chlorophyll metabolism	-1.77	4.31e-2	23/43 (53.49%)	ALAS2;HEPH;FECH;...
Various types of N-glycan biosynthesis	-1.77	4.92e-2	26/39 (66.67%)	MAN2A1;FUT8;DDOST;...
Butanoate metabolism	-1.81	4.62e-2	23/28 (82.14%)	AACS;ACSM3;HMGCS1;...
Rheumatoid arthritis	-1.84	3.28e-2	78/93 (83.87%)	CTLA4;ITGAL;ATP6V0A1;...
Pancreatic secretion	-1.86	3.69e-2	87/102 (85.29%)	PNLIP;ITPR1;CPB2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	4uM	6H

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H

Prostate

Prostate carcinoma

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H