General Information of Drug (ID: DMZT8LI)

Drug Name
WAY170523 Drug Info
Synonyms WAY-170523; WAY 170523
Cross-matching ID
PubChem CID
9830392
ChEBI ID
CHEMBL327002
TTD Drug ID
D0LL8I

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Protein processing in endoplasmic reticulum 2.44 0.00e+0 127/171 (74.27%) HERPUD1;DDIT3;P4HB;...
Ferroptosis 2.24 0.00e+0 36/41 (87.8%) HMOX1;SLC7A11;MAP1LC3B;...
Glycolysis / Gluconeogenesis 2.18 0.00e+0 56/67 (83.58%) ENO2;ALDOC;HK2;...
Fructose and mannose metabolism 2.17 0.00e+0 30/33 (90.91%) ALDOC;HK2;PFKP;...
HIF-1 signaling pathway 2.12 0.00e+0 105/109 (96.33%) VEGFA;ENO2;HMOX1;...
Starch and sucrose metabolism 2.07 0.00e+0 25/36 (69.44%) HK2;GPI;GBE1;...
Mitophagy 2.01 1.70e-3 56/68 (82.35%) BNIP3;BNIP3L;ATF4;...
Pentose phosphate pathway 1.98 1.49e-3 25/30 (83.33%) ALDOC;PFKP;PGD;...
Galactose metabolism 1.95 2.65e-3 26/31 (83.87%) HK2;PFKP;GLA;...
Other glycan degradation 1.86 8.35e-3 13/18 (72.22%) NEU1;GLB1;MANBA;...
Amino sugar and nucleotide sugar metabolism 1.83 1.08e-2 38/48 (79.17%) HK2;GFPT1;GPI;...
Mineral absorption 1.83 9.94e-3 48/60 (80%) HMOX1;ATP1A2;ATP2B1;...
Insulin resistance 1.80 1.28e-2 96/108 (88.89%) SLC2A1;PCK2;GFPT1;...
Cholesterol metabolism 1.80 1.19e-2 44/50 (88%) SORT1;LPL;APOA1;...
Insulin secretion 1.79 1.27e-2 75/86 (87.21%) SLC2A1;ATF4;KCNN4;...
Thyroid hormone synthesis 1.77 1.42e-2 66/75 (88%) ATF4;ATP1A2;HSPA5;...
Estrogen signaling pathway 1.77 1.40e-2 119/137 (86.86%) TFF1;HSPA6;ATF4;...
Central carbon metabolism in cancer 1.77 1.32e-2 67/70 (95.71%) SLC2A1;HK2;PFKP;...
Vitamin digestion and absorption 1.77 1.32e-2 17/24 (70.83%) APOA1;ABCC1;APOB;...
Vibrio cholerae infection 1.77 1.25e-2 44/50 (88%) ERO1A;KDELR3;PDIA4;...
Insulin signaling pathway 1.74 1.31e-2 121/137 (88.32%) HK2;PCK2;EIF4EBP1;...
Ether lipid metabolism 1.72 1.79e-2 32/49 (65.31%) PLPP3;PLD3;PLPP2;...
Hypertrophic cardiomyopathy 1.71 2.33e-2 81/90 (90%) TNNC1;TTN;ITGB4;...
TNF signaling pathway 1.69 2.43e-2 103/112 (91.96%) ATF4;CCL20;JUN;...
Cortisol synthesis and secretion 1.69 2.53e-2 58/65 (89.23%) ATF4;PDE8B;ITPR3;...
Fat digestion and absorption 1.68 2.71e-2 35/43 (81.4%) PLPP3;PLPP2;APOA1;...
Glycine, serine and threonine metabolism 1.66 3.18e-2 31/40 (77.5%) PHGDH;CTH;SHMT2;...
Renal cell carcinoma 1.66 3.07e-2 68/69 (98.55%) VEGFA;SLC2A1;CDKN1A;...
Legionellosis 1.66 2.96e-2 51/57 (89.47%) BNIP3;HSPA6;CXCL8;...
Steroid biosynthesis 1.65 3.50e-2 19/20 (95%) MSMO1;SOAT1;DHCR7;...
Nucleotide excision repair -1.63 3.60e-2 40/47 (85.11%) GTF2H4;RFC5;POLE;...
Thermogenesis -1.63 3.88e-2 173/232 (74.57%) ACSL4;SMARCC1;NDUFB8;...
Fanconi anemia pathway -1.67 3.11e-2 36/54 (66.67%) TOP3A;PALB2;FANCG;...
RNA polymerase -1.70 2.53e-2 23/31 (74.19%) POLR2B;POLR2K;POLR2L;...
Base excision repair -1.71 2.49e-2 29/33 (87.88%) NEIL3;POLE;POLD1;...
Complement and coagulation cascades -1.76 1.62e-2 76/85 (89.41%) SERPIND1;F12;F2;...
Cell cycle -1.78 1.19e-2 110/124 (88.71%) RBL2;ATM;ANAPC10;...
Spliceosome -1.85 1.04e-2 101/150 (67.33%) SRSF10;SRSF3;SRSF6;...
Mismatch repair -1.88 3.66e-3 22/23 (95.65%) RFC5;RPA3;RFC4;...
Oxidative phosphorylation -1.91 2.92e-3 93/133 (69.92%) NDUFB8;NDUFB5;SDHB;...
Systemic lupus erythematosus -1.92 3.66e-3 45/135 (33.33%) HLA-DMB;C8B;C1R;...
Asthma -1.95 2.44e-3 25/31 (80.65%) HLA-DRA;PRG2;CD40;...
Ribosome biogenesis in eukaryotes -2.16 0.00e+0 52/108 (48.15%) IMP3;RPP38;RPP30;...
DNA replication -2.39 0.00e+0 34/36 (94.44%) POLA1;RFC5;POLE;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 0.04uM - 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 6H, 24H