Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMZVS9Y)

Drug Name
OXYQUINOLINE Drug Info
Synonyms
8-HYDROXYQUINOLINE; quinolin-8-ol; 8-quinolinol; 148-24-3; Oxyquinoline; Oxine; Quinophenol; 8-Quinol; 8-Oxyquinoline; Phenopyridine; Oxychinolin; Bioquin; Oxybenzopyridine; Oxin; Hydroxybenzopyridine; 1-Azanaphthalene-8-ol; Tumex; 8-Chinolinol; 8-Hydroxychinolin; 8-OQ; 8-Hydroxy-chinolin; Fennosan H 30; Fennosan; o-Oxychinolin; 8-Oxychinolin; Usaf ek-794; Fennosan HF-15; NCI-C55298; NSC 2039; Oxyquinoline [USAN]; Caswell No. 719; Oxoquinoline; 8-Chinolinol [Czech]; o-Oxychinolin [German]; Quinoline, 8-hydroxy-; NSC 615011; UNII-5UTX5635HP
Cross-matching ID
PubChem CID
1923
ChEBI ID
CHEMBL48981
CAS Number
CAS 148-24-3
TTD Drug ID
D0FO2B

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid hormone biosynthesis 2.32 0.00e+0 43/61 (70.49%) AKR1C3;UGT2B15;AKR1C2;...
Metabolism of xenobiotics by cytochrome P450 2.07 0.00e+0 49/77 (63.64%) UGT2B15;AKR1C1;UGT2B17;...
Complement and coagulation cascades 2.00 0.00e+0 76/85 (89.41%) C4BPB;SERPINA1;C3;...
Retinol metabolism 1.94 6.99e-3 41/68 (60.29%) UGT2B15;UGT2B17;DGAT1;...
Mineral absorption 1.84 2.80e-2 48/60 (80%) TF;HEPH;MT1G;...
Asthma -1.75 4.87e-2 25/31 (80.65%) CCL11;HLA-DOA;HLA-DPB1;...
Viral myocarditis -1.88 1.08e-2 53/60 (88.33%) CD86;HLA-DQB1;ITGAL;...
Type I diabetes mellitus -1.89 1.35e-2 38/43 (88.37%) HSPD1;GAD1;CD86;...
Allograft rejection -2.00 3.61e-3 32/38 (84.21%) CD86;HLA-DQB1;HLA-B;...
Graft-versus-host disease -2.02 5.42e-3 32/42 (76.19%) CD86;HLA-DQB1;HLA-B;...
Autoimmune thyroid disease -2.25 0.00e+0 46/53 (86.79%) HLA-DOA;CTLA4;CGA;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 12uM - 100uM 48H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.08uM - 100uM 3H, 24H, 48H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.08uM - 20uM 24H