Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMZWQH3)

Drug Name
[125I]epibatidine Drug Info
Synonyms
CHEMBL6623; NLPRAJRHRHZCQQ-UHFFFAOYSA-N; 140111-52-0; [3H]EPIBATIDINE; SR-01000597620; [125I]EPIBATIDINE; AC1Q3PYA; AC1L1AYB; 208/210 Epibatidine; KBioSS_000603; KBioGR_000603; BSPBio_001263; (R)-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[221]heptane; [3H]epibatidine
Cross-matching ID
PubChem CID
1204
ChEBI ID
CHEMBL6623
TTD Drug ID
D0R4RN

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Hypertrophic cardiomyopathy -1.73 3.70e-2 81/90 (90%) CACNA1S;ITGA10;ITGB6;...
Mitophagy -1.74 4.08e-2 56/68 (82.35%) ULK1;BNIP3L;MITF;...
Insulin signaling pathway -1.74 4.90e-2 121/137 (88.32%) PIK3R1;FASN;MAPK9;...
Cardiac muscle contraction -1.81 4.08e-2 64/87 (73.56%) SLC8A1;CACNA1S;SLC9A1;...
Dilated cardiomyopathy -1.90 6.81e-3 86/96 (89.58%) SLC8A1;ADCY6;CACNA1S;...
Type II diabetes mellitus -1.94 1.36e-2 42/46 (91.3%) PIK3R1;MAPK9;PKM;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 25uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H