Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMZXF05)

• Drug Name: GTx-024 Drug Info
• Synonyms: (R)-Ostarine; 1132656-73-5; (2R)-3-(4-Cyanophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide; C19H14F3N3O3; 841205-47-8 pound not1202044-20-9; SCHEMBL2197534; CHEBI:94527; DTXSID70649384; BCPP000135; AOB87717; ZINC35793633; BCP9001038; NCGC00408913-01; AS-17044; FT-0673314; Y0247; 370C134; I06-2154; BRD-K16621777-001-01-9; (R)-N-(4-Cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide
• Cross-matching ID:
  PubChem CID: 11326715
  ChEBI ID: CHEMBL1738889
  CAS Number: CAS 841205-47-8
  TTD Drug ID: D0NE3W

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Oxidative phosphorylation	2.07	0.00e+0	93/133 (69.92%)	COX17;NDUFB6;SDHD;...
Malaria	2.06	0.00e+0	44/50 (88%)	THBS1;COMP;CD40;...
Ribosome	1.98	4.74e-3	113/158 (71.52%)	MRPL15;MRPL13;RPL26L1;...
Proteasome	1.90	5.34e-3	44/46 (95.65%)	PSMA1;PSMA4;PSMA6;...
Staphylococcus aureus infection	1.85	8.54e-3	72/95 (75.79%)	KRT14;KRT13;C1QA;...
Prion disease	1.73	3.91e-2	209/273 (76.56%)	CYCS;CAV2;C1QA;...
Toll-like receptor signaling pathway	1.72	3.76e-2	94/104 (90.38%)	CXCL10;CXCL9;LY96;...
Cysteine and methionine metabolism	1.71	3.74e-2	43/50 (86%)	ENOPH1;LDHA;BHMT2;...
Pyrimidine metabolism	1.70	3.95e-2	40/56 (71.43%)	UPP1;NME1;PNP;...
Purine metabolism	1.69	3.56e-2	102/129 (79.07%)	NUDT9;HPRT1;NME1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	3H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼