Details of the Drug Reposition

General Information of This Drug (ID: DMNI0KO)

Drug Name
Denosumab   DMNI0KO
Synonyms Denosumab (USAN); Denosumab (genetical recombination); Prolia (TN); Denosumab (genetical recombination) (JAN)
Drug Type
Antibody

Information on Drug Reposition of This Drug

Molecular Interaction Atlas (MIA)
2 Approved Indication(s)
Indication Name Indication ID ICD-11 Status REF
Drug-induced osteoporosis DISFK9Y9 N.A. Approved [1]
Osteoporosis DISF2JE0 FB83.0 Approved [2]
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1 Phase 3 Indication(s)
Indication Name Indication ID ICD-11 Status REF
Prostate cancer DISF190Y 2C82.0 Phase 3 [3]
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1 Phase 2 Indication(s)
Indication Name Indication ID ICD-11 Status REF
Rheumatoid arthritis DISTSB4J FA20 Phase 2 [3]
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References

1 Hormone-Related and Drug-Induced Osteoporosis: A Cellular and Molecular Overview. Int J Mol Sci. 2023 Mar 18;24(6):5814.
2 Denosumab and incidence of type 2 diabetes among adults with osteoporosis: population based cohort study. BMJ. 2023 Apr 18;381:e073435.
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6886).