Details of the Drug Reposition

General Information of This Drug (ID: DMNO38U)

Drug Name
Bortezomib   DMNO38U
Synonyms
179324-69-7; Velcade; Bortezomib (PS-341); UNII-69G8BD63PP; N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE; MLN-341; [(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid; [(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic acid; CHEMBL325041; 69G8BD63PP; Boronic acid,; DPBA; PROSCRIPT BORONIC ACID; LPD 341; LPD-341; VELCADE (TN); Velcade (TN); Pyz-Phe-boroLeu; Bortezomib(JAN/USAN/INN); Velcade, MG-341, PS-341, Bortezomib; N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-Nalpha-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide; Bortezomib (Proteasome inhibitor); Peptide boronate
Therapeutic Class
Anticancer Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

Information on Drug Reposition of This Drug

Molecular Interaction Atlas (MIA)
7 Approved Indication(s)
Indication Name Indication ID ICD-11 Status REF
Minimally invasive lung adenocarcinoma DIS4W83X N.A. Approved [1]
MALT lymphoma DIS1AVVE N.A. Approved [1]
Lymphoproliferative syndrome DISMVL8O N.A. Approved [1]
Leukemia DISNAKFL N.A. Approved [1]
Plasma cell myeloma DIS0DFZ0 2A83.1 Approved [1]
Recurrent adult burkitt lymphoma DIS6V60A 2A85.6 Approved [1]
Lung cancer DISCM4YA 2C25.0 Approved [1]
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⏷ Show the Full List of 7 Indications(s)
1 Phase 3 Indication(s)
Indication Name Indication ID ICD-11 Status REF
Non-hodgkin lymphoma DISS2Y8A 2B33.5 Phase 3 [2]
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1 Withdrawn Indication(s)
Indication Name Indication ID ICD-11 Status REF
Angioimmunoblastic T-cell Lymphoma DISZPFTL 2A90.9 Withdrawn [3]
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3 Investigative Indication(s)
Indication Name Indication ID ICD-11 Status REF
B-cell neoplasm DISVY326 N.A. Investigative [1]
Gastric cancer DISXGOUK 2B72 Investigative [1]
Colon cancer DISVC52G 2B90.Z Investigative [1]
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References

1 Bortezomib FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6391).
3 Endometriosis: Immunomodulation