Details of the Drug Reposition

General Information of This Drug (ID: DMUYKBZ)

Drug Name
Cyclosporin A   DMUYKBZ
Synonyms cyclosporin A; cyclosporine; Neoral; Cyclosporin; Ciclosporine; Sandimmun; Sang-35
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL

Information on Drug Reposition of This Drug

Molecular Interaction Atlas (MIA)
9 Approved Indication(s)
Indication Name Indication ID ICD-11 Status REF
Leukemia DISNAKFL N.A. Approved [1]
Bronchiolitis obliterans syndrome DISCK9IV N.A. Approved [2]
Adult acute monocytic leukemia DISG6BLX N.A. Approved [3]
Coronavirus Disease 2019 (COVID-19) DISM7GNX 1D6Y Approved [4]
Large granular lymphocytic leukemia DISHOPPI 2A90.1 Approved [5]
Myeloid leukaemia DISMN944 2B33.1 Approved [6]
Lupus nephritis DISCVGPZ 4A40.0Y Approved [7]
Xerophthalmia DIS5B72B 5B55.Y Approved [8]
Psoriasis DIS59VMN EA90 Approved [9]
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⏷ Show the Full List of 9 Indications(s)
1 Discontinued in Phase 3 Indication(s)
Indication Name Indication ID ICD-11 Status REF
Keratoconjunctivitis sicca DISNOENH 9A79 Discontinued in Phase 3 [10]
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1 Discontinued in Phase 1 Indication(s)
Indication Name Indication ID ICD-11 Status REF
Rheumatoid arthritis DISTSB4J FA20 Discontinued in Phase 1 [11]
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1 Investigative Indication(s)
Indication Name Indication ID ICD-11 Status REF
Corneal disease DISTUIM1 9A78.Z Investigative [12]
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References

1 Cyclosporin A protects JEG-3 cells against oxidative stress-induced apoptosis by inhibiting the p53 and JNK/p38 signaling pathways. Reprod Biol Endocrinol. 2020 Oct 12;18(1):100.
2 Bronchiolitis obliterans syndrome is associated with increased senescent lymphocytes in the small airways. J Heart Lung Transplant. 2021 Feb;40(2):108-119.
3 Clinical and biological impact of ATP-binding cassette transporter activity in adult acute myeloid leukemia. Haematologica. 2023 Jan 1;108(1):61-68.
4 Why Choose Cyclosporin A as First-line Therapy in COVID-19 Pneumonia. Reumatol Clin. 2020 Apr 16;S1699-258X(20)30044-9.
5 Rituximab for rheumatoid arthritis-associated large granular lymphocytic leukemia, a retrospective case series. Semin Arthritis Rheum. 2020 Oct;50(5):1109-1113.
6 Efficacy and safety of extended duration letermovir prophylaxis in recipients of haematopoietic stem-cell transplantation at risk of cytomegalovirus infection: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Haematol. 2024 Feb;11(2):e127-e135.
7 Efficacy and safety of Iguratimod as an add-on therapy for refractory lupus nephritis: A preliminary investigational study. Front Immunol. 2023 Mar 8;14:1062919.
8 Cyclosporin A (CyA) in primary Sj?gren's syndrome: a double blind study. Ann Rheum Dis. 1986 Sep;45(9):732-5.
9 Pustular psoriasis. Cutis. 1993 Jan;51(1):29-32.
10 Hyperthermia Treatment in Conjunction With Mitomycin C Versus Bacillus Calmette-Gurin Immunotherapy (BCG) for Superficial Bladder Cancer
11 Lenalidomide Therapy for Patients With Relapsed and/or Refractory, Peripheral T-Cell Lymphomas
12 Anti-inflammatory therapy of dry eye. Ocul Surf. 2003 Jan;1(1):31-6.