Details of the Drug

General Information of Drug (ID: DM051PI)

Drug Name
FR-180204
Synonyms
865362-74-9; FR 180204; FR180204; FR-180204; ERK Inhibitor II, FR180204; 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine; CHEMBL259551; 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE; C18H13N7; 5-{2-phenylpyrazolo[1,5-a]pyridin-3-yl}-1H-pyrazolo[3,4-c]pyridazin-3-amine; 5-{2-phenylpyrazolo[1,5-a]pyridin-3-yl}-2H-pyrazolo[3,4-c]pyridazin-3-amine; 5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-2H-pyrazolo[3,4-c]pyridazin-3-amine; ERK inhibitor II; MLS002607685
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 327.3
Logarithm of the Partition Coefficient (xlogp) 1.9
Rotatable Bond Count (rotbonds) 2
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 5
Chemical Identifiers
Formula
C18H13N7
IUPAC Name
5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-2H-pyrazolo[3,4-c]pyridazin-3-amine
Canonical SMILES
C1=CC=C(C=C1)C2=NN3C=CC=CC3=C2C4=CC5=C(NN=C5N=N4)N
InChI
InChI=1S/C18H13N7/c19-17-12-10-13(20-22-18(12)23-21-17)15-14-8-4-5-9-25(14)24-16(15)11-6-2-1-3-7-11/h1-10H,(H3,19,21,22,23)
InChIKey
XVECMUKVOMUNLE-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
11493598
ChEBI ID
CHEBI:91383
CAS Number
865362-74-9
UNII
4C7X7GV82C
DrugBank ID
DB07794
TTD ID
D0ZG4G

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Extracellular signal-regulated kinase 2 (ERK2) TT4TQBX MK01_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [3]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [3]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Gene/Protein Processing [3]
Signal transducer and activator of transcription 3 (STAT3) OTAAGKYZ STAT3_HUMAN Post-Translational Modifications [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Extracellular signal-regulated kinase 2 (ERK2) DTT MAPK1 6.78E-05 1.12 2.73
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 6.4882 8.363 3.6974 0.8107
ES5 GDSC1 4.0083 10.4618 0.9869 24.873
TC-71 GDSC1 4.0344 7.5745 2.4502 15.6696
EW-24 GDSC1 4.336 5.7808 3.6042 5.6098
EW-18 GDSC1 4.4175 8.6054 2.2593 15.5864
ES1 GDSC1 4.4577 5.957 3.6146 5.1061
SK-ES-1 GDSC1 4.8097 8.2816 2.7325 10.7849
EW-1 GDSC1 4.8806 8.0009 2.9247 9.111
CADO-ES1 GDSC1 4.9755 13.1573 0.4364 24.0107
EW-3 GDSC1 4.9812 7.5487 3.2195 6.5692
EW-7 GDSC1 5.0509 7.9076 3.0943 7.3194
ES7 GDSC1 5.0583 7.1743 3.4529 4.5994
EW-11 GDSC1 5.0719 12.0349 1.0712 20.6184
H-EMC-SS GDSC1 5.0748 7.6055 3.2573 6.0225
NOS-1 [Human HNSCC] GDSC1 5.1127 10.2766 1.9752 15.1449
MHH-ES-1 GDSC1 5.1957 7.6354 3.3246 5.2022
A-673 GDSC1 5.2804 7.0765 3.6377 2.7556
EW-13 GDSC1 5.3716 9.5781 2.509 10.704
EW-16 GDSC1 5.3755 11.0564 1.7873 15.5229
ES6 GDSC1 5.4906 8.566 3.0769 6.2805
ES4 GDSC1 5.6478 12.7438 1.1584 18.3514
ES8 GDSC1 5.8401 12.5562 1.3912 16.501
CAL-78 GDSC1 5.9323 7.815 3.665 1.5217
CHSA0011 GDSC1 5.9972 8.9518 3.2091 4.2375
HOS GDSC1 6.1392 7.6819 3.8094 0.636
HuO-3N1 GDSC1 6.3025 9.7003 3.0489 4.7083
SJSA-1 GDSC1 6.3249 8.0477 3.7485 0.7336
CAL-72 GDSC1 6.4928 8.5759 3.6179 1.1432
SK-PN-DW GDSC1 6.5054 8.7087 3.5716 1.3452
SaOS-2 GDSC1 6.6045 8.5433 3.6777 0.8003
MG-63 GDSC1 6.6229 8.3479 3.7571 0.51
NY GDSC1 6.6988 8.8222 3.6116 0.9906
CHSA0108 GDSC1 6.8043 8.6955 3.7016 0.5852
G-292 clone A141B1 GDSC1 6.9235 8.8192 3.703 0.5161
HuO9 GDSC1 7.0648 9.2464 3.6028 0.7596
CHSA8926 GDSC1 7.1329 8.8955 3.7539 0.2972
U2OS GDSC1 7.3094 9.5562 3.586 0.6701
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 144 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 5.6993 7.1747 3.8146 1.0153
SIG-M5 GDSC1 0.1024 4.3759 -0.2978 52.1208
ALL-SIL GDSC1 1.8455 6.8782 0.6594 36.8585
MOLM-13 GDSC1 2.2721 12.0955 -1.3821 39.9004
ALL-PO GDSC1 2.9831 5.9063 2.253 21.8061
GDM-1 GDSC1 3.5973 8.6538 1.526 23.6298
HAL-01 GDSC1 3.6962 6.5565 2.6483 15.5986
LAMA-84 GDSC1 3.7705 7.664 2.1717 18.7386
OCI-AML-2 GDSC1 3.8483 6.1916 2.968 12.5152
MY-M12 GDSC1 3.9105 14.8362 -1.2819 33.4818
OCI-Ly19 GDSC1 3.9635 8.2877 2.033 18.8922
MV4-11 GDSC1 4.0757 6.2236 3.1588 10.1011
THP-1 GDSC1 4.0979 5.9894 3.2948 8.949
MEG-01 GDSC1 4.1815 5.7949 3.4654 7.281
EoL-1 GDSC1 4.184 5.2249 3.7509 5.0289
MOLP-8 GDSC1 4.2467 7.5363 2.6517 13.3538
EM-2 GDSC1 4.2538 11.0016 0.9251 24.2408
OCI-AML-5 GDSC1 4.3169 5.2673 3.8451 3.779
ST486 GDSC1 4.3526 8.743 2.137 16.6763
KG-1 GDSC1 4.3635 6.9228 3.056 9.8199
PL-21 GDSC1 4.3957 8.0161 2.536 13.6675
SUP-B15 GDSC1 4.4032 11.7946 0.6531 24.9983
ML-2 GDSC1 4.4192 9.0386 2.0442 17.0621
P30/OHK GDSC1 4.4312 5.6004 3.7713 3.9626
VAL GDSC1 4.4648 6.8317 3.184 8.4628
OCI-M1 GDSC1 4.5424 5.5708 3.8704 2.8379
RS4;11 GDSC1 4.5441 6.1086 3.6063 4.8887
MOLT-13 GDSC1 4.5697 6.046 3.6567 4.4149
NKM-1 GDSC1 4.5734 9.0492 2.1645 15.6868
CCRF-CEM GDSC1 4.5989 6.2526 3.5766 4.9479
BV-173 GDSC1 4.6387 6.2157 3.6243 4.4554
MLMA GDSC1 4.6404 10.6074 1.4405 20.0464
697 GDSC1 4.665 7.2065 3.1546 8.0254
NOMO-1 GDSC1 4.7027 7.5791 2.9987 9.1086
HL-60 GDSC1 4.7078 7.0254 3.2767 6.9423
CESS GDSC1 4.7356 9.8979 1.8707 17.0782
MOLT-16 GDSC1 4.7456 7.3948 3.1227 8.0159
K-562 GDSC1 4.785 7.5092 3.0958 8.1003
RL GDSC1 4.7997 6.733 3.4876 5.0374
HEL GDSC1 4.8214 17.4429 -1.8271 31.9854
Karpas-45 GDSC1 4.8281 8.4688 2.6538 11.3116
KE-37 GDSC1 4.8304 7.7272 3.0223 8.5234
LP-1 GDSC1 4.891 10.2285 1.8284 16.8197
AMO1 GDSC1 4.9158 7.156 3.3642 5.6522
BE-13 GDSC1 4.9224 10.0893 1.9221 16.1122
BL-41 GDSC1 4.9438 6.8403 3.5357 4.2766
EJM GDSC1 4.9701 7.3747 3.2961 6.0177
NALM-6 GDSC1 4.9726 13.7422 0.1425 25.273
DND-41 GDSC1 4.9761 12.7564 0.6368 23.095
SU-DHL-6 GDSC1 4.9801 6.4973 3.7216 2.8141
RPMI-6666 GDSC1 5.0161 8.08 2.9854 8.2432
RPMI-8866 GDSC1 5.0926 7.9268 3.1144 7.0502
EB2 GDSC1 5.1111 7.6472 3.2621 5.8881
YT GDSC1 5.1225 8.4476 2.8822 8.7066
SU-DHL-5 GDSC1 5.1353 14.2918 -0.0025 25.3379
Mono-Mac-6 GDSC1 5.1546 12.4744 0.9171 21.1455
HH [Human lymphoma] GDSC1 5.1549 7.6109 3.3091 5.422
KCL-22 GDSC1 5.1693 8.2442 3.0142 7.5876
MOLT-4 GDSC1 5.2431 8.1323 3.119 6.6051
OCI-AML-3 GDSC1 5.2447 8.526 2.9304 8.0018
NU-DUL-1 GDSC1 5.2726 7.2752 3.5422 3.4387
KMS-11 GDSC1 5.2934 9.8495 2.32 12.2591
KMS-12-BM GDSC1 5.3213 7.8845 3.2887 5.1539
MHH-PREB-1 GDSC1 5.3261 11.5552 1.5043 17.3904
DEL GDSC1 5.3427 6.4121 3.9556 0.7045
TUR GDSC1 5.3432 7.1517 3.6403 2.6129
Karpas-422 GDSC1 5.3437 7.8816 3.3046 4.9842
WSU-NHL GDSC1 5.3794 6.8472 3.7936 1.5598
OPM-2 GDSC1 5.3839 7.8238 3.3571 4.5096
JJN-3 GDSC1 5.3946 6.772 3.8332 1.3015
RPMI-8402 GDSC1 5.4039 8.6747 2.9679 7.296
Reh GDSC1 5.404 10.8399 1.9149 14.6287
ME1 GDSC1 5.4129 10.379 2.1475 13.0775
HC-1 GDSC1 5.4364 7.2322 3.6571 2.3263
U266B1 GDSC1 5.4428 7.3192 3.6221 2.5443
ATN-1 GDSC1 5.4596 7.7417 3.4414 3.7434
QIMR-WIL GDSC1 5.4996 8.1746 3.2663 4.8942
CTV-1 GDSC1 5.5182 8.2698 3.2336 5.085
U-698-M GDSC1 5.5582 9.1834 2.8283 7.9067
JURL-MK1 GDSC1 5.5849 13.6248 0.6765 20.9876
BC-1 GDSC1 5.616 7.3357 3.7079 1.7131
Ramos.2G6.4C10 GDSC1 5.6194 7.3969 3.6837 1.853
A3/Kawakami GDSC1 5.6256 9.0765 2.9235 7.0524
KY821 GDSC1 5.6342 7.6505 3.5821 2.4606
JSC-1 GDSC1 5.6409 9.2441 2.8542 7.5102
L-540 GDSC1 5.6555 7.2473 3.7644 1.3341
SU-DHL-10 GDSC1 5.6575 6.6298 4.0045 0.2641
P31/FUJ GDSC1 5.6626 7.18 3.7954 1.1576
GR-ST GDSC1 5.6711 8.2065 3.3555 3.8971
RPMI-8226 GDSC1 5.6868 9.2757 2.8692 7.2882
SR GDSC1 5.6978 8.678 3.1558 5.229
TK [Human B-cell lymphoma] GDSC1 5.7148 10.1541 2.4691 10.0311
Hs 445 GDSC1 5.7264 7.417 3.729 1.4371
SU-DHL-1 GDSC1 5.7412 6.7628 3.9888 0.2683
JVM-3 GDSC1 5.7501 9.6939 2.7126 8.2389
L-363 GDSC1 5.7702 7.4114 3.7523 1.255
Raji GDSC1 5.805 7.0049 3.9256 0.4373
LC4-1 GDSC1 5.8088 10.44 2.3957 10.2848
SCC-3 GDSC1 5.8185 6.94 3.9547 0.3312
ARH-77 GDSC1 5.8271 7.7302 3.6485 1.7542
BALL-1 GDSC1 5.8415 7.7472 3.6486 1.7335
MC116 GDSC1 5.8974 6.8042 4.0313 0.1122
BC-3 GDSC1 5.9078 8.0175 3.5685 2.1047
KOPN-8 GDSC1 5.9141 10.4562 2.4586 9.5823
SUP-T1 GDSC1 5.9326 7.8297 3.6591 1.5532
KM-H2 GDSC1 5.986 8.4085 3.4421 2.7502
HT GDSC1 6.0059 7.607 3.7816 0.8613
SU-DHL-16 GDSC1 6.0182 7.1254 3.964 0.2138
JVM-2 GDSC1 6.0363 8.6001 3.3861 3.0171
DB GDSC1 6.0463 9.184 3.1332 4.6492
SK-MM-2 GDSC1 6.0523 19.6982 -1.976 29.03
PF-382 GDSC1 6.0992 8.1299 3.6161 1.5757
P12-Ichikawa GDSC1 6.1013 7.5633 3.8382 0.5545
SUP-M2 GDSC1 6.1015 7.2226 3.9605 0.1921
Karpas-620 GDSC1 6.1028 7.4766 3.8707 0.4401
H9 GDSC1 6.1785 13.734 1.0591 17.3588
SU-DHL-8 GDSC1 6.1796 7.6721 3.8294 0.5339
RC-K8 GDSC1 6.2305 7.6257 3.8663 0.3835
Granta-519 GDSC1 6.254 8.0134 3.7318 0.8586
Sc-1 GDSC1 6.2541 7.77 3.8231 0.5088
L-428 GDSC1 6.261 7.8035 3.8135 0.5376
SU-DHL-4 GDSC1 6.2685 7.5517 3.9068 0.2559
Karpas-299 GDSC1 6.2785 7.636 3.8808 0.3187
CTB-1 GDSC1 6.282 8.3276 3.6216 1.3373
P32/ISH GDSC1 6.3763 7.5987 3.9294 0.1711
KMOE-2 GDSC1 6.3889 8.146 3.738 0.7269
Namalwa GDSC1 6.3958 8.2188 3.7135 0.8184
Loucy GDSC1 6.4735 8.369 3.689 0.8556
WIL2 NS GDSC1 6.4915 7.826 3.8924 0.2104
DG-75 GDSC1 6.5503 8.4433 3.6929 0.7817
WSU-DLCL2 GDSC1 6.592 7.6287 3.993 0.0478
A4/Fukuda GDSC1 6.6104 7.813 3.9384 0.1038
MN-60 GDSC1 6.6144 8.5398 3.6831 0.7725
Jiyoye GDSC1 6.6553 8.2961 3.7881 0.4016
Ku812 GDSC1 6.7009 8.4035 3.7671 0.4394
ROS-50 GDSC1 6.7426 9.3629 3.4195 1.8373
Farage GDSC1 6.7455 8.3007 3.8199 0.2836
SUP-HD1 GDSC1 6.7626 8.5311 3.7449 0.4736
CA46 GDSC1 6.8647 8.7799 3.6945 0.5738
L-1236 GDSC1 6.8867 9.2392 3.5321 1.1666
Daudi GDSC1 6.895 8.5372 3.792 0.2941
VL51 GDSC1 6.9222 9.0365 3.6232 0.7806
NB4 GDSC1 7.3965 21.9724 -2.0906 26.1584
HDLM-2 GDSC1 7.5029 9.3912 3.7157 0.2619
⏷ Show the Full List of 144 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYAE-1 GDSC1 4.619 6.5883 3.4258 6.0607
OACP4 C GDSC1 4.8357 10.7161 1.5422 18.77
ESO-26 GDSC1 5.0173 8.9433 2.5621 11.384
TE-12 GDSC1 5.1415 7.8332 3.1935 6.3216
KYSE-50 GDSC1 5.3162 7.4287 3.4982 3.655
KYSE-220 GDSC1 5.9533 10.6042 2.4142 9.7836
ESO-51 GDSC1 6.3592 8.5376 3.5731 1.4936
SK-GT-4 GDSC1 6.3788 8.4195 3.6288 1.2029
OACM5.1 C GDSC1 6.543 14.397 0.9938 16.722
FLO-1 GDSC1 6.6196 14.1423 1.1696 15.6056
HCE-4 GDSC1 7.1152 8.8606 3.7596 0.2907
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 6.4994 8.3974 3.6891 0.8351
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CHP-126 GDSC1 4.3162 5.3751 3.7906 4.2115
SiMa GDSC1 4.323 8.452 2.2578 15.9455
NB(TU)1 GDSC1 4.3437 6.8019 3.1001 9.5471
SJNB-5 GDSC1 4.419 7.5359 2.7951 11.6362
NH-12 GDSC1 4.6738 6.2951 3.611 4.4541
LA-N-6 GDSC1 4.8528 7.0291 3.3812 5.7008
Kelly GDSC1 4.8989 7.5024 3.1832 7.0843
CHP-134 GDSC1 4.9514 7.028 3.4507 4.8967
SK-N-AS GDSC1 4.9682 10.1589 1.923 15.9544
SK-N-SH GDSC1 5.0284 7.2054 3.4179 4.9386
TGW GDSC1 5.0463 7.4531 3.3112 5.6941
MHH-NB-11 GDSC1 5.1296 8.9163 2.6582 10.3402
SJNB-14 GDSC1 5.291 7.5975 3.4041 4.3867
SJNB-13 GDSC1 5.4041 7.7743 3.3926 4.2094
SK-N-MC-IXC GDSC1 5.5695 6.6802 3.9506 0.514
GI-ME-N GDSC1 5.5959 9.1188 2.8841 7.4093
SJNB-17 GDSC1 5.6097 8.1178 3.3595 3.9964
KP-N-YS GDSC1 5.6668 8.3956 3.2668 4.519
SJNB-10 GDSC1 5.7719 7.4941 3.7193 1.4308
KP-N-YN GDSC1 5.7751 8.9212 3.091 5.5112
SJNB-6 GDSC1 5.8001 7.481 3.7382 1.2934
SK-N-DZ GDSC1 5.8919 7.4154 3.8062 0.8568
IMR-5 GDSC1 6.0709 7.7568 3.7518 0.9345
SK-N-FI GDSC1 6.0775 7.8539 3.7167 1.0909
SK-N-BE(2)-M17 GDSC1 6.1253 8.4217 3.5083 2.1401
SJNB-12 GDSC1 6.1778 8.2925 3.5873 1.6327
CHP-212 GDSC1 6.2312 8.1548 3.667 1.171
NB69 GDSC1 6.3261 12.6135 1.7041 13.3486
SJNB-7 GDSC1 6.3974 8.1323 3.7466 0.6878
NB1 GDSC1 6.4135 13.4402 1.3662 15.0686
GOTO GDSC1 6.6818 8.3364 3.7837 0.4013
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 5.3451 9.0086 2.7668 8.9249
Cancer Drug Sensitivity Data Curated from 51 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MDA-MB-175-VII GDSC1 4.5843 5.9627 3.7086 3.9658
CAL-85-1 GDSC1 4.6052 6.6737 3.3729 6.5176
DU4475 GDSC1 4.7353 6.2922 3.6564 3.9278
HDQ-P1 GDSC1 4.7856 7.3049 3.197 7.3188
HCC1599 GDSC1 5.0155 6.8688 3.5698 3.84
HCC1419 GDSC1 5.3467 8.0387 3.2325 5.5029
UACC-812 GDSC1 5.428 8.2743 3.1739 5.7299
HCC1806 GDSC1 5.4295 8.5704 3.0347 6.7413
MDA-MB-361 GDSC1 5.4418 8.7069 2.9779 7.1244
HCC202 GDSC1 5.46 9.4576 2.6296 9.5957
CAL-120 GDSC1 5.4887 7.4445 3.5924 2.6552
T-47D GDSC1 5.5855 9.3326 2.7753 8.2161
EFM-192A GDSC1 5.64 9.3948 2.782 8.0274
Evsa-T GDSC1 5.712 7.7707 3.5718 2.3938
BT-549 GDSC1 5.7314 9.7253 2.6853 8.4784
ZR-75-30 GDSC1 5.7556 9.6963 2.7151 8.2077
MRK-nu-1 GDSC1 5.7937 7.1343 3.8723 0.6545
MDA-MB-330 GDSC1 5.8157 8.0933 3.4875 2.7511
BT-483 GDSC1 5.8392 8.1894 3.4583 2.8965
CAL-148 GDSC1 5.8695 7.3686 3.8146 0.8397
HCC1569 GDSC1 5.8788 9.1604 3.0442 5.6073
OCUB-M GDSC1 5.9425 8.1462 3.5317 2.2714
AU565 GDSC1 5.9454 9.2453 3.0456 5.4532
BT-474 GDSC1 5.9459 11.8697 1.8008 13.7792
CAMA-1 GDSC1 5.9756 7.5102 3.8059 0.7818
HCC1428 GDSC1 6.0343 7.5858 3.8019 0.7482
HCC1187 GDSC1 6.0401 8.8896 3.2612 3.8124
JIMT-1 GDSC1 6.1411 7.6436 3.8245 0.5777
HCC1937 GDSC1 6.1609 8.7081 3.4054 2.6956
HCC38 GDSC1 6.1655 8.4683 3.5089 2.0804
YMB-1-E GDSC1 6.204 9.0315 3.2889 3.3443
MDA-MB-453 GDSC1 6.2122 8.0239 3.7098 0.9916
HCC1500 GDSC1 6.2397 8.0043 3.7292 0.8819
MDA-MB-468 GDSC1 6.2489 8.243 3.6401 1.2818
UACC-893 GDSC1 6.2585 8.5032 3.5398 1.7866
MDA-MB-436 GDSC1 6.3794 8.0788 3.7593 0.6534
MDA-MB-415 GDSC1 6.3932 8.132 3.745 0.6969
HCC70 GDSC1 6.4012 19.3321 -1.5286 26.9375
EFM-19 GDSC1 6.4866 8.4274 3.6724 0.9133
MDA-MB-157 GDSC1 6.4928 8.8212 3.5212 1.6052
MDA-MB-231 GDSC1 6.4964 8.7296 3.5593 1.4134
BT-20 GDSC1 6.5002 8.2584 3.7414 0.6368
HCC2218 GDSC1 6.5133 8.6357 3.6037 1.1883
HCC2157 GDSC1 6.5265 8.0793 3.8166 0.382
Hs 578T GDSC1 6.5969 8.5083 3.6877 0.7676
MFM-223 GDSC1 6.6587 8.206 3.8212 0.3131
CAL-51 GDSC1 6.7692 8.3461 3.8127 0.2916
COLO 824 GDSC1 6.7801 8.706 3.6882 0.6439
HCC1954 GDSC1 6.7833 8.5955 3.7296 0.5087
HCC1395 GDSC1 6.8165 8.4905 3.7796 0.3537
MCF-7 GDSC1 6.9688 8.8508 3.7089 0.4763
⏷ Show the Full List of 51 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AM-38 GDSC1 4.4428 7.4975 2.8338 11.2557
D-566MG GDSC1 4.8922 6.5223 3.653 3.5324
D-423MG GDSC1 4.9073 7.3948 3.2418 6.6108
LN-229 GDSC1 4.9126 6.4581 3.6969 3.1558
U-118MG GDSC1 5.0007 6.8499 3.569 3.8826
D-502MG GDSC1 5.0705 7.3745 3.3654 5.2213
D-247MG GDSC1 5.3862 10.2092 2.2112 12.7276
Hs 683 GDSC1 5.4276 7.1987 3.667 2.2777
SF126 GDSC1 5.4343 6.949 3.7787 1.565
DK-MG GDSC1 5.5164 7.4312 3.6137 2.4648
A-172 GDSC1 5.5681 7.5392 3.5947 2.4955
KNS-42 GDSC1 5.5908 7.8257 3.4804 3.2085
YH-13 GDSC1 5.6614 9.0395 2.9642 6.6737
D-263MG GDSC1 5.6772 7.1887 3.7987 1.1225
LNZTA3WT4 GDSC1 5.7392 7.5242 3.6908 1.6352
42-MG-BA GDSC1 5.7489 9.645 2.735 8.0841
DBTRG-05MG GDSC1 5.7531 8.587 3.2312 4.5827
SW1088 GDSC1 5.7666 7.839 3.5713 2.3069
Daoy GDSC1 5.8289 7.3878 3.789 1.0014
LN-18 GDSC1 5.8352 6.7138 4.0402 0.1123
NMC-G1 GDSC1 5.8804 7.8663 3.6182 1.8535
GaMG GDSC1 5.9089 9.5227 2.8951 6.5766
H4 GDSC1 5.9587 8.0053 3.5992 1.8528
LN-405 GDSC1 5.9764 7.844 3.6742 1.4179
KNS-81-FD GDSC1 6.0017 7.9209 3.6549 1.489
YKG-1 GDSC1 6.014 8.4235 3.4505 2.6532
PFSK-1 GDSC1 6.0146 8.1325 3.574 1.9191
Becker GDSC1 6.0329 10.3592 2.5823 8.443
U-87MG ATCC GDSC1 6.041 8.0462 3.6225 1.614
KS-1 [Human Krukenberg tumour] GDSC1 6.0424 8.2323 3.5461 2.0398
D283 Med GDSC1 6.0855 7.5787 3.826 0.6116
D-392MG GDSC1 6.1065 8.6231 3.4134 2.7327
CAS-1 GDSC1 6.2049 7.4499 3.9191 0.2508
M059J GDSC1 6.3131 8.2842 3.6526 1.1565
D-336MG GDSC1 6.3292 9.5367 3.1363 4.0938
D-542MG GDSC1 6.3449 7.5967 3.9189 0.2015
SF539 GDSC1 6.377 11.323 2.35 9.1731
8-MG-BA GDSC1 6.4324 10.1451 2.9243 5.2727
T98G GDSC1 6.476 9.0941 3.4021 2.2593
GB-1 GDSC1 6.5152 9.6777 3.1754 3.5311
ONS-76 GDSC1 6.6029 8.4819 3.7 0.7176
SF295 GDSC1 6.6202 8.0044 3.8771 0.2025
SK-MG-1 GDSC1 6.7123 8.2266 3.8335 0.2644
Onda 10 GDSC1 6.8031 8.5888 3.7397 0.4686
U-251MG GDSC1 6.873 8.187 3.9032 0.1042
SW1783 GDSC1 6.8861 8.8821 3.6656 0.6557
KINGS-1 GDSC1 6.9597 8.9296 3.6772 0.576
GI-1 GDSC1 6.9787 8.7394 3.7521 0.3573
SF268 GDSC1 7.0261 13.1906 1.8875 10.5674
Onda 11 GDSC1 7.0318 8.9711 3.6899 0.5004
MOG-G-CCM GDSC1 7.1537 9.2182 3.6478 0.563
SNB-75 GDSC1 7.1859 9.1575 3.6817 0.4517
MOG-G-UVW GDSC1 7.312 8.9065 3.8131 0.1461
KALS-1 GDSC1 7.4257 9.8297 3.5319 0.7785
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC24TKB GDSC1 5.6409 8.5886 3.162 5.3136
ETK-1 GDSC1 5.8456 8.4745 3.3359 3.6852
TGBC1TKB GDSC1 6.3778 7.9921 3.7906 0.543
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MFE-280 GDSC1 5.4735 8.2883 3.1967 5.4553
MFE-319 GDSC1 5.9081 7.3415 3.8417 0.6872
MFE-296 GDSC1 6.1402 8.1306 3.6351 1.4275
EN GDSC1 6.3757 7.8881 3.8276 0.4248
KLE GDSC1 6.4875 14.0134 1.1407 16.1005
ESS-1 GDSC1 6.9435 8.2649 3.9013 0.0955
RL95-2 GDSC1 7.0239 8.5307 3.84 0.1651
AN3-CA GDSC1 7.2654 9.4343 3.613 0.61
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KTCTL-21 GDSC1 4.6042 7.0558 3.1825 8.0063
KTCTL-140 GDSC1 4.8071 6.8278 3.4467 5.3298
KTCTL-195 GDSC1 4.8171 6.6323 3.5489 4.5197
KTCTL-26A GDSC1 4.8381 6.3179 3.7144 3.2128
TK-10 GDSC1 5.0082 8.0082 3.0148 8.0443
KTCTL-1M GDSC1 5.0763 10.358 1.9072 15.7038
RCC10RGB GDSC1 5.1853 7.6574 3.3072 5.3579
HA7-RCC GDSC1 5.2035 7.3759 3.4523 4.2442
UO-31 GDSC1 5.349 7.3675 3.5461 3.2473
A-498 GDSC1 5.3564 7.596 3.4456 3.9389
Caki-1 GDSC1 5.5544 9.6823 2.5863 9.6444
VMRC-RCZ GDSC1 5.6421 7.9327 3.4619 3.2341
NCC021 GDSC1 5.6564 8.1412 3.3765 3.7838
786-O GDSC1 5.6633 8.3183 3.3001 4.2953
SN12C GDSC1 5.7573 7.5477 3.69 1.6146
VMRC-RCW GDSC1 5.7647 8.6175 3.2242 4.6068
LB2241-RCC GDSC1 5.9247 7.8505 3.6467 1.632
SW156 GDSC1 6.0385 9.4498 3.008 5.5116
OS-RC-2 GDSC1 6.0641 8.2257 3.5597 1.9321
BFTC-909 GDSC1 6.0756 7.8457 3.7191 1.0815
LB1047-RCC GDSC1 6.1156 8.5846 3.4346 2.5896
A-704 GDSC1 6.1534 8.3332 3.5589 1.8168
769-P GDSC1 6.1655 7.9418 3.7213 0.9835
LB996-RCC GDSC1 6.5665 9.1638 3.4172 2.0592
RXF 393L GDSC1 6.5808 9.2815 3.3758 2.2659
KMRC-1 GDSC1 6.6332 7.8214 3.9434 0.0935
KMRC-20 GDSC1 6.7358 7.9325 3.9412 0.0805
KTCTL-13 GDSC1 6.7817 9.0836 3.5469 1.1946
SW13 GDSC1 6.8194 8.3105 3.843 0.2113
BB65-RCC GDSC1 6.9058 8.5066 3.8065 0.2588
CAL-54 GDSC1 7.3171 9.3414 3.6657 0.4376
ACHN GDSC1 8.2508 16.2022 1.249 11.516
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-175 GDSC1 4.3239 6.1331 3.418 7.1214
SW48 GDSC1 4.5891 6.6457 3.3745 6.5573
COLO205 GDSC1 4.6138 6.1528 3.6369 4.433
KM12 GDSC1 4.6413 6.1248 3.6708 4.0877
LS411N GDSC1 4.6466 9.1842 2.1558 15.4887
LS513 GDSC1 4.7757 7.0314 3.3242 6.3666
GP5d GDSC1 4.7776 7.8943 2.8999 9.6239
SNU-C5 GDSC1 4.8467 7.0973 3.3436 6.0072
CCK-81 GDSC1 4.9329 8.2897 2.8213 9.7297
SNU-1040 GDSC1 4.942 10.7676 1.6001 18.0637
HCT 15 GDSC1 4.9557 6.6279 3.6447 3.4348
NCI-H747 GDSC1 5.1249 8.3162 2.948 8.2087
SW948 GDSC1 5.1799 7.2114 3.5143 3.8493
SNU-61 GDSC1 5.2489 9.4546 2.4812 11.2608
LS123 GDSC1 5.2966 7.684 3.3672 4.6416
SW837 GDSC1 5.2993 7.9316 3.2522 5.4758
RKO GDSC1 5.4974 7.1831 3.7114 1.876
T84 GDSC1 5.4988 7.6754 3.4948 3.2933
SW1417 GDSC1 5.5139 9.2529 2.7651 8.4776
SW620 GDSC1 5.6058 8.0849 3.3721 3.9173
HT-29 GDSC1 5.6103 10.8999 2.035 13.2423
C2BBe1 GDSC1 5.6787 9.5711 2.7238 8.342
HCT 116 GDSC1 5.6842 8.172 3.3788 3.7122
CW-2 GDSC1 5.78 8.312 3.3711 3.5761
HT-55 GDSC1 5.8798 7.4022 3.806 0.8692
COLO 320HSR GDSC1 5.9636 7.8443 3.668 1.4663
LS1034 GDSC1 5.9732 12.0594 1.728 14.1493
NCI-H716 GDSC1 5.9781 8.2506 3.5057 2.3734
MDST8 GDSC1 5.9862 10.9823 2.2558 10.7595
RCM-1 [Human ESC] GDSC1 6.1171 7.5375 3.854 0.4878
SW626 GDSC1 6.1768 11.4318 2.1686 10.8416
SNU-C2B GDSC1 6.1914 9.609 3.026 5.0762
HT115 GDSC1 6.2135 7.5342 3.8925 0.3163
SNU-81 GDSC1 6.2147 7.779 3.8039 0.6026
CaR-1 GDSC1 6.2296 7.8766 3.7735 0.7079
SNU-407 GDSC1 6.2638 13.9105 1.0338 17.258
SW1463 GDSC1 6.3127 8.0385 3.7469 0.7493
SW1116 GDSC1 6.3174 8.0222 3.755 0.714
LS180 GDSC1 6.3379 8.3421 3.641 1.1866
SNU-C1 GDSC1 6.374 8.5551 3.573 1.478
COLO 678 GDSC1 6.5437 8.8327 3.5399 1.4577
HCC2998 GDSC1 6.8694 8.5341 3.7838 0.3225
CL-11 GDSC1 7.0411 8.9844 3.6887 0.4995
LoVo GDSC1 7.073 9.1983 3.6237 0.6836
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 4.7878 6.8775 3.4086 5.6798
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-1 GDSC1 4.2875 5.5698 3.6691 5.2744
JHH-4 GDSC1 4.4837 5.6022 3.8111 3.4794
JHH-6 GDSC1 4.8263 6.1415 3.7903 2.6797
JHH-2 GDSC1 5.1 6.6546 3.7226 2.5418
SNU-387 GDSC1 5.4529 8.0162 3.3107 4.6835
SNU-449 GDSC1 5.5484 7.5902 3.5613 2.7499
SK-HEP-1 GDSC1 5.9082 7.3518 3.8378 0.7035
SNU-423 GDSC1 5.9525 7.765 3.6949 1.3374
HLE GDSC1 5.9639 8.7042 3.3006 3.6956
JHH-7 GDSC1 6.0458 7.7283 3.7518 0.9582
Hep-G2/C3A GDSC1 6.1427 7.3874 3.918 0.2789
Hep 3B2.1-7 GDSC1 6.2797 7.7452 3.8421 0.4315
HuH-1 GDSC1 6.3764 7.7851 3.8646 0.3188
SNU-398 GDSC1 6.4409 8.3702 3.6749 0.9409
SNU-475 GDSC1 6.664 8.0584 3.8742 0.1956
Huh-7 GDSC1 7.0055 8.54 3.8304 0.1852
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 170 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H3255 GDSC1 4.1654 8.3133 2.1944 16.9876
PaCa-3 GDSC1 4.2099 7.9772 2.4001 15.3529
NCI-H2110 GDSC1 4.2837 7.6163 2.6428 13.2821
PC-14 GDSC1 4.3793 8.1743 2.4433 14.4072
SW1271 GDSC1 4.4015 7.4331 2.8321 11.4153
NCI-H1770 GDSC1 4.4482 5.8021 3.6843 4.5898
HCC827 GDSC1 4.5169 7.3986 2.9429 10.1589
NCI-H2731 GDSC1 4.5313 6.6659 3.3195 7.1764
NCI-H292 GDSC1 4.5729 10.1111 1.6338 19.1377
EMC-BAC-1 GDSC1 4.5738 7.9354 2.7205 11.6599
NCI-H2135 GDSC1 4.6821 6.6739 3.4309 5.8244
NCI-H2444 GDSC1 4.698 6.6892 3.4352 5.7425
SK-MES-1 GDSC1 4.706 6.907 3.3338 6.5049
NCI-H1688 GDSC1 4.7104 8.502 2.5461 12.4938
RERF-LC-MS GDSC1 4.7256 6.66 3.4699 5.391
NCI-H810 GDSC1 4.7324 6.1981 3.7 3.6025
NCI-H211 GDSC1 4.7398 6.7879 3.4174 5.7539
NCI-H1993 GDSC1 4.7929 8.8119 2.4563 12.8721
NCI-H1048 GDSC1 4.8534 6.8778 3.4552 5.1327
NCI-H1563 GDSC1 4.8555 7.6415 3.0831 7.9811
CAL-12T GDSC1 4.8613 6.5667 3.611 3.9278
COR-L321 GDSC1 4.9182 6.1375 3.8498 2.0378
COR-L303 GDSC1 4.9572 6.7088 3.6073 3.7077
NCI-H1869 GDSC1 4.959 6.8207 3.5553 4.0902
NCI-H847 GDSC1 5.048 6.8607 3.5946 3.5778
NCI-H2227 GDSC1 5.0939 7.1931 3.4675 4.4013
NCI-H510A GDSC1 5.1073 7.2465 3.4509 4.4898
Ms-1 GDSC1 5.1078 7.2258 3.4611 4.4134
EPLC-272H GDSC1 5.1734 8.1363 3.0693 7.1649
NCI-H1944 GDSC1 5.1743 10.8057 1.7601 16.3227
NCI-H2081 GDSC1 5.189 6.8718 3.6766 2.6749
NCI-H209 GDSC1 5.1944 7.4344 3.4189 4.5104
LC-2/ad GDSC1 5.2045 7.8349 3.2354 5.8419
NCI-H2029 GDSC1 5.2117 6.9779 3.6418 2.8699
NCI-H226 GDSC1 5.2276 7.1162 3.588 3.2137
NCI-H1092 GDSC1 5.2536 7.122 3.6011 3.0656
COR-L105 GDSC1 5.2612 8.4664 2.9707 7.6578
SBC-3 GDSC1 5.303 6.9021 3.7286 2.1006
NCI-H2196 GDSC1 5.3306 9.0985 2.7131 9.3561
BEN GDSC1 5.3368 6.5195 3.9095 0.9504
NCI-H727 GDSC1 5.3624 8.4437 3.0504 6.7994
COR-L23 GDSC1 5.3801 7.4616 3.5217 3.3515
NCI-H1436 GDSC1 5.3906 7.3563 3.5757 2.958
NCI-H2085 GDSC1 5.4111 9.1749 2.7323 8.9927
COLO 668 GDSC1 5.4215 8.9347 2.8551 8.073
NCI-H1623 GDSC1 5.4492 7.5562 3.5196 3.2234
LCLC-103H GDSC1 5.4516 6.9875 3.7712 1.5833
NCI-H1573 GDSC1 5.455 7.5996 3.5034 3.3234
NCI-H358 GDSC1 5.4578 11.5257 1.6172 16.3133
NCI-H720 GDSC1 5.4719 7.0458 3.7569 1.6385
NCI-H1838 GDSC1 5.4741 8.1849 3.2454 5.1028
HARA [Human squamous cell lung carcinoma] GDSC1 5.4797 7.1875 3.7001 1.9755
NCI-H1836 GDSC1 5.4816 6.9081 3.8197 1.2571
Lu-65 GDSC1 5.4975 8.7045 3.0158 6.7064
ABC-1 GDSC1 5.5099 8.9155 2.9238 7.3421
LCLC-97TM1 GDSC1 5.5301 8.7487 3.0163 6.6215
CPC-N GDSC1 5.533 8.2248 3.2637 4.836
NCI-H322M GDSC1 5.5336 8.5817 3.0974 6.0276
EKVX GDSC1 5.5349 7.9467 3.3929 3.9219
NCI-H1876 GDSC1 5.5797 7.7564 3.505 3.0651
NCI-H1975 GDSC1 5.6224 8.1243 3.3641 3.9383
NCI-H1693 GDSC1 5.6453 12.1297 1.4585 16.6843
NCI-H64 GDSC1 5.6493 6.8532 3.9184 0.582
EBC-1 GDSC1 5.6573 8.4188 3.2504 4.6541
NCI-H3122 GDSC1 5.676 8.3873 3.2762 4.4343
Calu-6 GDSC1 5.6941 7.3097 3.7575 1.3223
NCI-H1666 GDSC1 5.7045 7.9319 3.4973 2.8837
NCI-H1648 GDSC1 5.7053 7.8927 3.515 2.7678
SBC-5 GDSC1 5.7275 6.8447 3.9537 0.3885
NCI-H2795 GDSC1 5.7296 8.2068 3.3893 3.5514
DMS 273 GDSC1 5.7603 9.4369 2.8408 7.3094
SW1573 GDSC1 5.7863 8.3361 3.3639 3.612
NCI-H522 GDSC1 5.7996 10.7988 2.2169 11.514
EMC-BAC-2 GDSC1 5.8075 8.0541 3.5001 2.685
NCI-H526 GDSC1 5.809 10.1558 2.5318 9.3501
A-427 GDSC1 5.8211 8.0406 3.5133 2.579
NCI-H460 GDSC1 5.8269 7.2839 3.8289 0.8152
NCI-H838 GDSC1 5.8311 7.1576 3.8792 0.5953
NCI-H1568 GDSC1 5.833 8.9317 3.1215 5.1716
NCI-H345 GDSC1 5.8373 6.6638 4.0579 0.0829
NCI-H2030 GDSC1 5.839 9.7846 2.7278 7.9109
COR-L88 GDSC1 5.8435 7.7893 3.632 1.8264
NCI-H187 GDSC1 5.8457 7.0214 3.9357 0.377
IA-LM GDSC1 5.848 8.522 3.316 3.813
NCI-H661 GDSC1 5.8763 8.2772 3.4402 2.9479
NCI-H647 GDSC1 5.889 8.7874 3.2204 4.3761
NCI-H2405 GDSC1 5.8978 11.2514 2.0663 12.2348
UMC-11 GDSC1 5.8986 7.8813 3.6211 1.8114
HOP-92 GDSC1 5.9001 8.0171 3.5647 2.1387
NCI-H1437 GDSC1 5.9045 7.9396 3.5997 1.9267
NCI-H82 GDSC1 5.9206 7.5094 3.7822 0.9398
NCI-H2087 GDSC1 5.9244 7.9923 3.5875 1.9686
NCI-H2803 GDSC1 5.9292 8.8139 3.2319 4.2187
NCI-H2369 GDSC1 5.9465 7.5042 3.7956 0.8536
DMS 79 GDSC1 5.9521 7.7403 3.7047 1.2876
Lu-135 GDSC1 5.9877 8.2504 3.5107 2.3286
NCI-H513 GDSC1 6.0294 12.9213 1.3488 16.2035
Lu-139 GDSC1 6.035 7.6802 3.7658 0.9048
LOU-NH91 GDSC1 6.0447 8.0446 3.6249 1.5964
NCI-H1694 GDSC1 6.0701 7.8282 3.7235 1.0661
RERF-LC-Sq1 GDSC1 6.0772 10.0128 2.7724 7.0388
HCC78 GDSC1 6.08 7.6589 3.7933 0.7461
NCI-H2291 GDSC1 6.0896 8.0912 3.6273 1.5281
SHP-77 GDSC1 6.1188 7.8902 3.7208 1.0303
NCI-H1581 GDSC1 6.1333 7.759 3.7778 0.7668
Lu-99A GDSC1 6.1344 9.0764 3.2312 3.8345
Lu-165 GDSC1 6.1684 7.5768 3.8599 0.4372
NCI-H1299 GDSC1 6.1756 10.8395 2.4481 9.0043
NCI-H1792 GDSC1 6.1777 9.3086 3.1526 4.2661
NCI-H2342 GDSC1 6.1812 8.3597 3.5615 1.7672
NCI-H650 GDSC1 6.1889 8.1547 3.6479 1.308
Calu-3 GDSC1 6.1957 7.7558 3.8049 0.6123
LK-2 GDSC1 6.1991 8.0641 3.6883 1.1028
NCI-H1755 GDSC1 6.2025 11.4033 2.1992 10.5784
NCI-H1793 GDSC1 6.2253 7.802 3.7997 0.611
NCI-H2373 GDSC1 6.2581 8.9069 3.3711 2.7516
NCI-H1304 GDSC1 6.2815 8.1714 3.6827 1.0487
NCI-H2170 GDSC1 6.2935 8.2549 3.6554 1.1629
NCI-H1435 GDSC1 6.2967 7.9233 3.7835 0.6211
COR-L95 GDSC1 6.3186 8.6724 3.4994 1.9292
NCI-H446 GDSC1 6.331 8.1604 3.7083 0.8926
NCI-H2347 GDSC1 6.3498 8.4707 3.5955 1.3923
IST-SL1 GDSC1 6.3502 8.2744 3.6727 1.03
NCI-H841 GDSC1 6.3511 8.0854 3.7452 0.727
HCC33 GDSC1 6.3549 7.8812 3.8221 0.4531
NCI-H2023 GDSC1 6.3739 9.2692 3.2766 3.1415
NCI-H1650 GDSC1 6.3951 12.8858 1.6203 13.6652
NCI-H1963 GDSC1 6.429 8.3192 3.6893 0.8906
HOP-62 GDSC1 6.4347 8.0227 3.8018 0.4731
RERF-LC-KJ GDSC1 6.4466 8.3177 3.6972 0.8437
NCI-H2228 GDSC1 6.4629 8.8755 3.4854 1.8247
NCI-H2122 GDSC1 6.4682 8.0704 3.7975 0.468
NCI-H2804 GDSC1 6.5021 9.4109 3.2826 2.9079
DMS 53 GDSC1 6.5135 8.6686 3.5909 1.2464
NCI-H1651 GDSC1 6.5211 8.613 3.6159 1.1261
NCI-H2141 GDSC1 6.5304 8.1036 3.8094 0.4004
HCC15 GDSC1 6.5312 8.8401 3.5313 1.5129
NCI-H1155 GDSC1 6.5471 8.2525 3.7622 0.5367
NCI-H1781 GDSC1 6.5515 7.9293 3.8784 0.2208
NCI-H1355 GDSC1 6.5789 8.4836 3.6896 0.7735
ChaGo-K-1 GDSC1 6.6202 8.8342 3.5733 1.2252
DMS 114 GDSC1 6.6219 8.0579 3.8593 0.2384
NCI-H1915 GDSC1 6.6579 8.2755 3.7964 0.3775
NCI-H2171 GDSC1 6.6745 8.0418 3.8835 0.1755
COR-L311 GDSC1 6.6879 8.2398 3.8201 0.3044
NCI-H69 GDSC1 6.7075 8.7727 3.634 0.8933
NCI-H196 GDSC1 6.7118 8.2604 3.8217 0.2918
NCI-H596 GDSC1 6.7407 8.3283 3.8085 0.3122
NCI-H1734 GDSC1 6.7505 8.7319 3.6669 0.738
NCI-H2461 GDSC1 6.7617 9.3325 3.4404 1.7113
SK-LU-1 GDSC1 6.7733 8.8411 3.6355 0.8387
NCI-H2591 GDSC1 6.8101 8.8257 3.6561 0.7368
NCI-H520 GDSC1 6.8182 12.5298 2.0649 9.963
NCI-H2009 GDSC1 6.8815 8.9447 3.6408 0.7444
NCI-H524 GDSC1 6.8924 8.6403 3.755 0.3852
NCI-H748 GDSC1 6.9436 8.8484 3.7002 0.5142
NCI-H2595 GDSC1 6.9491 9.0402 3.6326 0.7295
A-549 GDSC1 6.9536 8.7492 3.7393 0.4
SBC-1 GDSC1 6.9566 8.4637 3.8391 0.1822
LXF 289 GDSC1 6.9868 8.9511 3.6798 0.5532
NCI-H2722 GDSC1 7.0549 8.7805 3.7656 0.2979
NCI-H2818 GDSC1 7.1087 8.8432 3.7633 0.2849
NCI-H23 GDSC1 7.1394 9.2277 3.6389 0.5976
NCI-H441 GDSC1 7.1498 9.0892 3.6923 0.4392
NCI-H2869 GDSC1 7.2524 9.243 3.6763 0.4372
LC-1/sq GDSC1 7.3616 9.2495 3.714 0.3078
HCC44 GDSC1 7.468 9.3963 3.7015 0.3001
Lu-134-A GDSC1 7.5245 9.3249 3.7458 0.2036
NCI-H1703 GDSC1 7.5426 9.3022 3.7597 0.1778
NCI-H2172 GDSC1 9.0417 17.6537 1.0574 10.9796
⏷ Show the Full List of 170 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 6.1679 13.7569 1.0403 17.486
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-15 GDSC1 4.2167 6.1329 3.3273 8.2321
TE-8 GDSC1 4.9199 7.0831 3.4024 5.3496
KYSE-150 GDSC1 5.1687 6.594 3.7899 1.9447
KYSE-270 GDSC1 5.2225 8.8367 2.764 9.2923
TE-10 GDSC1 5.3467 7.6486 3.4153 4.1776
KYSE-140 GDSC1 5.4952 10.872 1.9658 14.028
EC-GI-10 GDSC1 5.5312 7.2689 3.6924 1.9391
OE33 GDSC1 5.6871 10.4248 2.3197 11.1304
T.T GDSC1 5.742 8.0371 3.4717 2.9828
TE-9 GDSC1 5.8174 7.5026 3.7376 1.2754
TE-6 GDSC1 5.8604 7.8319 3.6226 1.8565
KYSE-70 GDSC1 5.9301 7.6941 3.7131 1.2699
KYSE-510 GDSC1 6.0383 8.4473 3.453 2.599
TE-4 GDSC1 6.0723 7.8972 3.6973 1.1906
OE21 GDSC1 6.0966 11.9525 1.8652 12.9728
OE19 GDSC1 6.2827 7.6213 3.8875 0.2989
TE-5 GDSC1 6.3592 8.0301 3.7692 0.6308
KYSE-410 GDSC1 6.3747 7.9243 3.8141 0.4673
KYSE-450 GDSC1 6.8133 8.1706 3.8883 0.1356
KYSE-180 GDSC1 6.8602 8.587 3.7618 0.3811
COLO 680N GDSC1 6.9508 8.6322 3.7793 0.3033
TE-1 GDSC1 7.1873 8.644 3.858 0.1093
TE-11 GDSC1 7.2418 8.6274 3.8817 0.0765
KYSE-520 GDSC1 8.0014 9.9348 3.7053 0.1667
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TOV-112D GDSC1 4.367 6.294 3.3732 7.3194
FU-OV-1 GDSC1 4.5111 7.608 2.8337 11.0169
JHOS-2 GDSC1 4.5864 15.7397 -1.1681 30.9771
DOV13 GDSC1 4.6043 6.7957 3.3118 6.9975
OVCAR-5 GDSC1 4.7962 7.6413 3.039 8.5016
OVISE GDSC1 4.8412 6.7079 3.5291 4.6038
OVCAR-8 GDSC1 4.9333 7.2739 3.3192 5.9458
IGROV-1 GDSC1 5.0237 12.8554 0.625 22.9938
EFO-27 GDSC1 5.0962 10.6419 1.7818 16.4381
EFO-21 GDSC1 5.1752 6.9019 3.6546 2.8575
A2780 GDSC1 5.4177 10.1087 2.2831 12.1451
Caov-3 GDSC1 5.436 8.3338 3.1511 5.8765
OVTOKO GDSC1 5.4689 8.336 3.1713 5.6493
OVK18 GDSC1 5.5204 7.1949 3.7184 1.7964
OV-90 GDSC1 5.5554 7.6106 3.5562 2.7709
OC 314 GDSC1 5.6313 9.6352 2.6613 8.9076
OAW42 GDSC1 5.6781 7.0961 3.8363 0.9306
OVKATE GDSC1 5.712 11.4968 1.8167 14.3401
RMG-I GDSC1 5.7784 11.1411 2.0366 12.7556
OV56 GDSC1 5.8302 6.8543 3.9898 0.2247
OAW28 GDSC1 5.8501 11.5644 1.8817 13.5424
TOV-21G GDSC1 5.8566 7.352 3.8154 0.8485
Kuramochi GDSC1 6.0011 10.2826 2.5979 8.4135
SK-OV-3 GDSC1 6.0116 10.2885 2.6019 8.3608
OVCAR-4 GDSC1 6.0437 11.1051 2.2357 10.7432
OVCAR-3 GDSC1 6.5207 8.0903 3.8105 0.402
ES-2 GDSC1 6.828 8.4003 3.8152 0.2656
Caov-4 GDSC1 6.9199 8.8544 3.689 0.5609
TYK-nu GDSC1 7.1608 8.5143 3.8919 0.0764
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MZ-PC-1 GDSC1 4.1295 7.6413 2.4993 14.9365
PSN1 GDSC1 4.1887 6.6093 3.0654 10.3926
Capan-1 GDSC1 4.6838 6.4265 3.5539 4.8659
QGP-1 GDSC1 4.6865 12.1593 0.7027 23.7631
KP-2 GDSC1 4.7194 6.1984 3.6908 3.7095
Panc 10.05 GDSC1 4.9704 7.2784 3.343 5.6603
PaTu 8988t GDSC1 4.9839 6.5308 3.7083 2.9016
Panc 04.03 GDSC1 5.1928 7.423 3.4232 4.4832
HPAC GDSC1 5.2692 6.8538 3.7311 2.1465
PL4 GDSC1 5.2748 7.2542 3.5533 3.3558
HPAF-II GDSC1 5.275 9.1599 2.6439 10.0163
HuP-T3 GDSC1 5.4147 10.5613 2.0594 13.6575
Panc 08.13 GDSC1 5.416 12.3261 1.191 18.8797
SU.86.86 GDSC1 5.4586 7.2546 3.6595 2.2711
YAPC GDSC1 5.4762 7.4724 3.5728 2.8094
Capan-2 GDSC1 5.5245 8.6496 3.0594 6.3235
DAN-G GDSC1 5.5872 7.7165 3.5271 2.9038
CFPAC-1 GDSC1 5.6185 7.5622 3.6121 2.2969
BxPC-3 GDSC1 5.7961 8.2976 3.3866 3.4423
PaTu 8902 GDSC1 5.9042 7.6554 3.7166 1.282
KP-3 GDSC1 5.9064 8.335 3.4313 2.9526
MIA PaCa-2 GDSC1 6.1858 7.7477 3.8038 0.6232
KP-4 GDSC1 6.1921 7.5627 3.8742 0.3796
SW1990 GDSC1 6.2749 8.5026 3.5479 1.7231
Panc 03.27 GDSC1 6.3923 11.5451 2.2556 9.7497
Hs 766T GDSC1 6.4942 7.9332 3.8562 0.2917
Panc 02.03 GDSC1 6.7561 13.7093 1.469 13.6244
HuP-T4 GDSC1 7.0677 8.844 3.7482 0.3328
AsPC-1 GDSC1 7.5224 15.4371 1.1515 13.5453
SUIT-2 GDSC1 9.0879 24.8746 -2.3049 23.2789
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IST-Mes1 GDSC1 5.2916 7.6582 3.3761 4.5888
NCI-H28 GDSC1 5.8897 8.191 3.4849 2.6428
NCI-H2052 GDSC1 5.9267 7.9491 3.6068 1.8543
MPP 89 GDSC1 5.927 7.6456 3.7311 1.1815
MSTO-211H GDSC1 7.03 8.8416 3.7351 0.379
NCI-H2452 GDSC1 7.2885 9.3248 3.6609 0.4623
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
22Rv1 GDSC1 4.2984 5.4608 3.7327 4.7331
VCaP GDSC1 4.4552 6.1843 3.4993 6.0203
LNCaP clone FGC GDSC1 5.3216 7.3827 3.5227 3.4701
DU145 GDSC1 5.8101 8.3857 3.3553 3.624
PC-3 GDSC1 5.9165 9.1472 3.0731 5.3257
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 6.9089 8.6277 3.7655 0.3516
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
WM35 GDSC1 3.9937 7.9042 2.2504 17.2696
SK-MEL-24 GDSC1 4.403 6.695 3.2022 8.5358
MZ-MEL-7 GDSC1 4.4224 10.2965 1.418 20.9643
A-375 GDSC1 4.4552 5.6181 3.7813 3.8049
M14 GDSC1 4.4708 11.5977 0.8074 24.0224
Mel Ho GDSC1 4.5681 15.0412 -0.834 30.0559
VMRC-MELG GDSC1 4.5848 8.7772 2.3094 14.6334
WM115 GDSC1 4.6948 5.9825 3.7781 3.1119
A101D GDSC1 4.7343 6.1666 3.7166 3.4714
RVH-421 GDSC1 4.7353 11.1405 1.2507 20.7876
SH-4 GDSC1 4.9267 11.6675 1.1401 20.7343
SK-MEL-28 GDSC1 4.9399 7.6803 3.1258 7.4018
CHL-1 GDSC1 4.9439 10.1316 1.9178 16.0688
IGR-37 GDSC1 4.9796 7.3238 3.3275 5.7531
SK-MEL-5 GDSC1 4.9999 6.8527 3.5671 3.8985
COLO 792 GDSC1 5.0058 6.6791 3.6529 3.2529
CP50-MEL-B GDSC1 5.0287 8.1147 2.9774 8.266
UACC-257 GDSC1 5.0808 6.3035 3.8692 1.5842
MMAc-SF GDSC1 5.1448 6.9885 3.5961 3.3406
LB373-MEL-D GDSC1 5.1781 6.5411 3.8185 1.7397
RPMI-7951 GDSC1 5.1882 6.8901 3.6678 2.7377
IGR-1 GDSC1 5.2212 6.7351 3.7567 2.0664
COLO 829 GDSC1 5.2715 7.3632 3.5009 3.7349
Mel JuSo GDSC1 5.3615 6.896 3.7632 1.7767
CP66-MEL GDSC1 5.3704 6.9743 3.734 1.9465
G-361 GDSC1 5.4747 7.1864 3.698 1.9975
IPC-298 GDSC1 5.4837 7.1146 3.7337 1.7612
Hs 938.T GDSC1 5.5133 8.9184 2.9246 7.3274
MZ-MEL-2 GDSC1 5.5143 8.4513 3.1462 5.7219
451Lu GDSC1 5.5298 7.3878 3.6401 2.2707
A2058 GDSC1 5.5422 6.5908 3.9729 0.4457
A-431 GDSC1 5.5786 7.3783 3.6703 1.9988
WM793 GDSC1 5.586 9.6133 2.6412 9.1709
WM278 GDSC1 5.6221 10.6449 2.1676 12.3356
LB2518-MEL GDSC1 5.6301 7.2738 3.741 1.5002
WM1552C GDSC1 5.6611 7.3032 3.7441 1.4397
SK-MEL-1 GDSC1 5.6619 7.1316 3.8146 1.058
UACC-62 GDSC1 5.6734 7.2099 3.7883 1.1819
GAK GDSC1 5.7118 7.0427 3.8723 0.7271
SK-MEL-30 GDSC1 5.7159 9.8043 2.6374 8.8557
HT-144 GDSC1 5.8046 7.9839 3.529 2.5079
COLO 679 GDSC1 5.8895 7.6609 3.7074 1.3475
Hs 940.T GDSC1 5.9043 7.5924 3.7419 1.1524
SK-MEL-2 GDSC1 5.9076 6.8947 4.004 0.1623
LOX-IMVI GDSC1 5.971 7.557 3.7857 0.8749
G-mel GDSC1 6.0268 7.8381 3.7 1.2268
WT2-iPS GDSC1 6.0562 7.1928 3.9544 0.2225
COLO 783 GDSC1 6.1686 7.6837 3.8207 0.5727
COLO 800 GDSC1 6.169 8.073 3.6714 1.2143
HMV-II GDSC1 6.2431 10.1248 2.8223 6.3342
DJM-1 GDSC1 6.2545 8.8619 3.3883 2.6542
A-388 GDSC1 6.7163 8.6775 3.6732 0.738
MeWo GDSC1 6.8183 8.5205 3.7697 0.3785
SK-MEL-3 GDSC1 6.9685 14.809 1.0862 15.1735
IST-MEL1 GDSC1 7.2083 8.9988 3.7454 0.2907
EquiPSC Line K2 GDSC1 4.8548 7.4615 3.171 7.3085
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 5.6274 7.8256 3.5012 2.9998
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RKN GDSC1 4.7236 6.2232 3.6817 3.7673
G-401 GDSC1 4.8929 6.6264 3.6038 3.8991
TE 441.T GDSC1 4.9007 6.5222 3.6587 3.4686
EW-8 GDSC1 5.1198 7.8353 3.1775 6.5001
SW982 GDSC1 5.2316 6.9431 3.6694 2.637
RD GDSC1 5.7828 8.1533 3.4431 3.0953
A-204 GDSC1 5.9964 9.5044 2.9576 5.948
Hs 633.T GDSC1 6.0902 7.5862 3.8251 0.6115
Rh41 GDSC1 6.0958 7.7442 3.7675 0.8423
HT-1080 GDSC1 6.1022 7.4752 3.871 0.4396
SW872 GDSC1 6.1584 7.8554 3.7516 0.8562
MFH-ino GDSC1 6.1647 8.229 3.6069 1.5451
KYM-1 GDSC1 6.181 7.5917 3.8594 0.4318
GCT GDSC1 6.2274 7.8557 3.7805 0.6823
MES-SA GDSC1 6.3776 7.7096 3.8916 0.251
G-402 GDSC1 6.3781 8.9819 3.4004 2.4031
SW684 GDSC1 6.4197 7.497 3.9787 0.0844
VA-ES-BJ GDSC1 6.4266 8.0859 3.7756 0.5643
Rh30 GDSC1 6.5388 7.9008 3.8837 0.2137
SK-UT-1 GDSC1 7.0452 8.6383 3.8109 0.2094
SK-LMS-1 GDSC1 7.3621 8.7222 3.8906 0.0568
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NUGC-4 GDSC1 3.7459 6.7742 2.5879 15.8369
RERF-GC-1B GDSC1 5.0423 9.583 2.265 13.4162
Fu97 GDSC1 5.253 7.0446 3.636 2.8234
MKN1 GDSC1 5.3204 7.1079 3.6468 2.6134
23132/87 GDSC1 5.5337 8.3257 3.2173 5.166
GCIY GDSC1 5.588 7.6251 3.5679 2.6342
MKN7 GDSC1 5.6153 8.3877 3.2392 4.8253
IM95 GDSC1 5.6284 10.4933 2.2456 11.7953
OCUM-1 GDSC1 5.8336 8.459 3.336 3.7074
MKN28 GDSC1 5.8894 10.6153 2.3662 10.2731
AGS GDSC1 5.9436 7.6081 3.7536 1.0525
MKN45 GDSC1 5.9468 7.2158 3.9045 0.4206
RF-48 GDSC1 5.995 11.8583 1.8405 13.3995
SNU-1 GDSC1 6.0554 12.7023 1.4738 15.4228
ECC10 GDSC1 6.0679 7.8742 3.7044 1.1605
Hs 746.T GDSC1 6.1106 7.6222 3.82 0.6161
NCI-N87 GDSC1 6.171 9.6494 2.9958 5.3194
SCH GDSC1 6.2642 7.9244 3.7699 0.696
SNU-16 GDSC1 6.2913 7.5261 3.924 0.2081
TGBC11TKB GDSC1 6.2957 8.1228 3.7077 0.9257
HSC-39 GDSC1 6.3806 8.0536 3.7691 0.6167
TMK-1 GDSC1 6.4084 8.4476 3.6309 1.1643
HGC-27 GDSC1 6.5139 8.1285 3.7942 0.4537
SNU-5 GDSC1 6.5671 7.9523 3.876 0.2207
NUGC-3 GDSC1 6.578 8.4354 3.7072 0.7082
SNG-M GDSC1 5.7149 8.2346 3.3684 3.7218
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BHT-101 GDSC1 4.6531 5.8926 3.7925 3.1178
HTC-C3 GDSC1 4.6952 7.3986 3.0825 8.4868
B-CPAP GDSC1 5.2677 8.0089 3.1945 5.9811
K5 GDSC1 5.3019 9.0173 2.7323 9.297
8305C GDSC1 5.5455 10.1833 2.3378 11.4022
ML-1 [Human leukemia] GDSC1 5.6408 7.4194 3.6851 1.8116
8505C GDSC1 5.6434 8.0593 3.4058 3.6097
CGTH-W-1 GDSC1 5.7094 7.6359 3.6284 2.0479
TT2609-C02 GDSC1 5.7793 8.2513 3.3977 3.4005
IHH-4 GDSC1 5.8097 7.5185 3.7275 1.3384
CAL-62 GDSC1 5.9288 7.8597 3.6449 1.6363
WRO GDSC1 6.13 7.7652 3.774 0.7853
FTC-133 GDSC1 6.3572 7.6781 3.8952 0.2502
ASH-3 GDSC1 6.4217 7.9448 3.8249 0.4091
TT GDSC1 6.5426 7.8593 3.8992 0.1819
KMH-2 GDSC1 6.7849 8.5284 3.7543 0.4354
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H3118 GDSC1 4.7968 6.8456 3.4306 5.4837
BB30-HNC GDSC1 4.8956 6.7987 3.5229 4.5016
BICR 31 GDSC1 4.9483 6.5818 3.6616 3.328
HSC-4 GDSC1 4.9611 6.4702 3.7223 2.8538
PCI-06A GDSC1 4.9707 7.57 3.2016 6.7347
CAL-27 GDSC1 5.0049 6.6198 3.68 3.0575
SCC-25 GDSC1 5.1212 7.2053 3.4795 4.2444
BHY GDSC1 5.1418 7.6837 3.2654 5.7821
SCC-9 GDSC1 5.1649 7.8591 3.197 6.2323
OSC-19 GDSC1 5.185 6.8019 3.706 2.4798
HSC-2 GDSC1 5.2359 6.5087 3.8635 1.359
SKN-3 GDSC1 5.2434 7.9796 3.1923 6.0601
Ca9-22 GDSC1 5.2606 8.5312 2.9389 7.8943
SAS GDSC1 5.277 10.0719 2.1989 13.1396
HO-1-u-1 GDSC1 5.5669 7.8609 3.4507 3.4572
HO-1-N-1 GDSC1 5.6209 7.8281 3.4965 3.0433
BICR 78 GDSC1 5.6419 8.4509 3.2263 4.8569
LB771-HNC GDSC1 5.7119 8.2201 3.3731 3.6952
JHU-011 GDSC1 5.8052 7.8184 3.6003 2.0698
CAL-33 GDSC1 5.8189 7.8725 3.5844 2.1447
OSC-20 GDSC1 5.8734 7.7685 3.6555 1.6509
SCC-4 GDSC1 5.8768 8.0344 3.5453 2.2909
PE/CA-PJ15 GDSC1 6.0979 8.328 3.5338 2.0322
HSC-3 GDSC1 6.3426 7.7155 3.8766 0.3019
Detroit 562 GDSC1 6.3851 8.05 3.7722 0.6027
BICR 10 GDSC1 6.3868 7.998 3.792 0.5328
SAT [Human HNSCC] GDSC1 6.4493 8.9949 3.43 2.1398
BICR 22 GDSC1 6.5131 7.6738 3.9516 0.1035
PCI-15A GDSC1 6.5621 8.2241 3.7783 0.4769
FaDu GDSC1 6.6156 8.3676 3.7471 0.5462
PCI-04B GDSC1 6.6381 8.7619 3.6089 1.0526
SCC-15 GDSC1 6.8205 8.6025 3.7414 0.4551
KON GDSC1 6.8341 8.3697 3.828 0.2367
PCI-30 GDSC1 6.9021 9.4655 3.4511 1.514
PCI-38 GDSC1 6.9131 8.5598 3.7907 0.2906
DOK GDSC1 6.9871 9.0922 3.6286 0.7194
BB49-HNC GDSC1 7.0592 9.21 3.614 0.7247
JHU-022 GDSC1 7.1612 10.0478 3.3378 1.7859
KOSC-2 GDSC1 7.2164 9.1738 3.6873 0.424
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RT-4 GDSC1 4.9931 7.3364 3.3307 5.6912
BFTC-905 GDSC1 5.21 7.2426 3.5187 3.7476
CAL-29 GDSC1 5.2492 7.7136 3.3226 5.0831
SW1710 GDSC1 5.3215 9.2158 2.6497 9.8405
TCCSUP GDSC1 5.4823 7.3254 3.6414 2.3457
639V GDSC1 5.8701 7.0999 3.9166 0.4268
5637 GDSC1 5.9241 8.6122 3.319 3.6484
KU-19-19 GDSC1 6.0649 7.416 3.8779 0.4389
RT-112 GDSC1 6.2657 11.0278 2.4175 8.9926
SW780 GDSC1 6.3829 7.8948 3.828 0.4198
HT-1197 GDSC1 6.4585 7.8689 3.8656 0.2826
T24 GDSC1 6.483 11.1789 2.4834 8.0598
647V GDSC1 6.4856 7.6588 3.9472 0.115
J82 GDSC1 7.0199 8.6512 3.7976 0.2419
HT-1376 GDSC1 7.2478 9.1621 3.703 0.3724
UM-UC-3 GDSC1 8.7597 17.1321 1.1283 11.1485
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OVCA420 GDSC1 4.3927 5.4711 3.8052 3.826
BPH-1 GDSC1 4.5433 13.005 0.1635 26.6225
OVMIU GDSC1 4.7538 8.3028 2.679 11.3662
DSH1 GDSC1 4.765 6.3931 3.6283 4.0586
PA-1 GDSC1 4.8171 7.3688 3.1889 7.2845
C-33 A GDSC1 5.2319 7.3354 3.4892 3.9101
JHOS-3 GDSC1 5.2694 8.9857 2.7247 9.4454
NEC8 GDSC1 5.3789 6.9443 3.7516 1.8205
DoTc2 4510 GDSC1 5.4274 7.4911 3.5363 3.1533
UWB1.289 GDSC1 5.4782 9.7431 2.504 10.436
SW954 GDSC1 5.574 8.2614 3.2721 4.6846
SW962 GDSC1 5.5803 7.6704 3.5437 2.8072
ME-180 GDSC1 5.6409 9.2234 2.864 7.44
JEG-3 GDSC1 5.6603 7.4398 3.6865 1.7741
OV17R GDSC1 5.688 8.5938 3.1886 5.0201
ACC-OV7 GDSC1 5.7193 9.1055 2.9702 6.4915
JAR GDSC1 5.769 7.4962 3.717 1.4472
OVCA433 GDSC1 5.8146 9.5958 2.801 7.4578
HeLa GDSC1 5.8211 6.7836 4.0112 0.1759
SiHa GDSC1 5.9115 7.3718 3.8315 0.7272
NT2-D1 GDSC1 5.9146 8.3238 3.4406 2.8797
Ca Ski GDSC1 6.0216 9.6705 2.8964 6.3129
OMC-1 [Human cervical carcinoma] GDSC1 6.0592 7.888 3.6949 1.2164
HEY GDSC1 6.2286 8.5838 3.4921 2.0891
CAL-39 GDSC1 6.3325 8.761 3.4696 2.0749
C-4-I GDSC1 6.3437 7.9727 3.7842 0.5872
KGN GDSC1 6.3587 9.0183 3.3753 2.5758
SKG-IIIa GDSC1 6.3943 8.3117 3.6774 0.9703
SKN GDSC1 6.4118 8.3087 3.686 0.9184
SW756 GDSC1 6.4835 7.9362 3.8512 0.3085
HEC-1 GDSC1 6.5207 7.8254 3.9031 0.1807
LB831-BLC GDSC1 6.5575 8.8956 3.5212 1.5344
NCC-IT GDSC1 6.5575 8.2377 3.7716 0.5003
MS751 GDSC1 6.561 8.042 3.8427 0.2986
HT-3 GDSC1 6.6464 8.6854 3.6415 0.9108
PEO1 GDSC1 6.8361 8.5821 3.7545 0.4112
SiSo GDSC1 7.5901 9.5243 3.7011 0.2654
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5966).
2 Crystal structure of human ERK2 complexed with a pyrazolo[3,4-c]pyridazine derivative. Bioorg Med Chem Lett. 2006 Jan 1;16(1):55-8.
3 Molecular mechanisms of quinalizarin induces apoptosis and G0/G1 cell cycle of human esophageal cancer HCE-4 cells depends on MAPK, STAT3, and NF-B signaling pathways. Environ Toxicol. 2021 Feb;36(2):276-286. doi: 10.1002/tox.23033. Epub 2020 Oct 8.