Details of the Drug

General Information of Drug (ID: DM09CUO)

Drug Name

CTL-102-GDEPT

Synonyms

CTL-102; NTR-GDEPT; GDEPT (CTL-102), ML Laboratories; Gene directed chemotherapy (CTL-102), ML Laboratories; Ad-NTR + CB-1954 GDEPT, ML Labs; Human adenovirus (hAdV5) GDEPT (E coli nitroreductase (NTR)/CB-1954, aseptic prosthetic implant loosening), Broadvector

Indication

Disease Entry	ICD 11	Status	REF
Head and neck cancer	2D42	Discontinued in Phase 2	[1]
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Cross-matching ID

TTD ID: D0E0FY

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Aldose reductase (AKR1B1)	TTFBNVI	ALDR_HUMAN	Modulator	[2]

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Molecular Interaction Atlas (MIA)

MIA Detail

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Molecular Expression Atlas of This Drug

ICD Disease Classification

02 Neoplasm

Disease Class

ICD-11: 2C82 Prostate cancer

The Studied Tissue

Head and neck tissue

The Studied Disease

Head and neck cancer [ICD-11:2C82]

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Aldose reductase (AKR1B1)	DTT	AKR1B1	1.08E-20	0.94	1.58

Molecular Expression Atlas (MEA)

MEA Detail

Jump to Detail Molecular Expression Atlas of This Drug

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011583)
2	Genes in the Service of Therapeutic Index: Progress for Virus-Directed Enzyme Prodrug Therapy. JCO May 1, 2004 vol. 22 no. 9 1535-1537c.