Details of the Drug

General Information of Drug (ID: DM0AEDT)

Drug Name

Tofersen

Synonyms

BIIB067; IONIS-SOD1RX; Tofersen

Indication

Disease Entry	ICD 11	Status	REF
Amyotrophic lateral sclerosis	8B60.0	Approved	[1]
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Drug Type

Antisense oligonucleotide

Sequence

CAGGATACATTTCTACAGCU

Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
SOD1 messenger RNA (SOD1 mRNA)	TTP9K3Q	SODC_HUMAN	Inhibitor	[2]
Superoxide dismutase Cu-Zn (SOD Cu-Zn)	TT6RVLG	SODC_HUMAN	Inhibitor	[2]

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Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	FDA Approved Drug Products from FDA Official Website. 2023. Application Number: 215887.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)