Details of the Drug

General Information of Drug (ID: DM0P729)

Drug Name
GSK461364
Synonyms
GSK461364; 929095-18-1; GSK-461364; 5-[6-[(4-Methyl-1-piperazinyl)methyl]-1h-benzimidazol-1-yl]-3-[(1r)-1-[2-(trifluoromethyl)phenyl]ethoxy]-2-thiophenecarboxamide; GSK 461364; UNII-8QO27TK6Q4; GSK-461364A; (R)-5-(6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide; 8QO27TK6Q4; CHEMBL1908394; GSK461364A; ZHJGWYRLJUCMRT-QGZVFWFLSA-N; SCHEMBL310080; GTPL5684; C27H28F3N5O2S; CTK8B7590; CHEBI:91333; DTXSID60239197; MolPort-016-633-304; BCP01720; GSK 461364A
Indication
Disease Entry ICD 11 Status REF
Non-hodgkin lymphoma 2B33.5 Phase 1 [1]
Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
Therapeutic Class
Anticancer Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 543.6
Logarithm of the Partition Coefficient (xlogp) 4.7
Rotatable Bond Count (rotbonds) 7
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 9
Chemical Identifiers
Formula
C27H28F3N5O2S
IUPAC Name
5-[6-[(4-methylpiperazin-1-yl)methyl]benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]thiophene-2-carboxamide
Canonical SMILES
C[C@H](C1=CC=CC=C1C(F)(F)F)OC2=C(SC(=C2)N3C=NC4=C3C=C(C=C4)CN5CCN(CC5)C)C(=O)N
InChI
InChI=1S/C27H28F3N5O2S/c1-17(19-5-3-4-6-20(19)27(28,29)30)37-23-14-24(38-25(23)26(31)36)35-16-32-21-8-7-18(13-22(21)35)15-34-11-9-33(2)10-12-34/h3-8,13-14,16-17H,9-12,15H2,1-2H3,(H2,31,36)/t17-/m1/s1
InChIKey
ZHJGWYRLJUCMRT-QGZVFWFLSA-N
Cross-matching ID
PubChem CID
15983966
ChEBI ID
CHEBI:91333
CAS Number
929095-18-1
TTD ID
D08RMJ
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Polo-like kinase 1 (PLK1) TTIYVQP PLK1_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [3]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [3]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Protein Interaction/Cellular Processes [3]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Gene/Protein Processing [3]
Serine-protein kinase ATM (ATM) OTQVOHLT ATM_HUMAN Post-Translational Modifications [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Non-hodgkin lymphoma
ICD Disease Classification 2B33.5
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Polo-like kinase 1 (PLK1) DTT PLK1 4.16E-07 -0.38 -0.72
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 150 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JK1 CTRP2 -8.4411 1.849 -8.8478 77.9611
MEC1 CTRP2 -6.2807 -5.6945 -6.2807 82.1114
JM1 CTRP2 -10.8291 -7.5507 -10.8291 97.4932
KYO-1 CTRP2 -14.1863 3.6781 -15.4357 81.4216
KO52 CTRP2 -13.8885 -0.8718 -14.3546 86.4059
MOLM-6 CTRP2 -13.6227 3.2249 -14.72 81.5701
EJM CTRP2 -13.2027 6.3048 -15.0322 77.8547
Granta-519 CTRP2 -12.9443 1.9399 -13.7195 82.7085
SUP-T11 CTRP2 -12.522 8.5817 -14.9634 75.0505
CA46 CTRP2 -12.4285 -1.8775 -12.6293 87.9997
GDM-1 CTRP2 -12.3534 23.7496 -20.6092 65.7466
DB CTRP2 -12.3001 0.9509 -12.8502 83.6157
MOLP-8 CTRP2 -12.2244 5.8132 -13.8302 77.4855
SUP-T1 CTRP2 -12.1419 0.3468 -12.5875 84.387
BCP-1 CTRP2 -11.5657 -3.4285 -11.6483 89.6566
HuT 78 CTRP2 -11.2043 4.0226 -12.2686 78.5362
A4/Fukuda CTRP2 -11.1684 -1.2574 -11.3628 86.2749
Hs 611.T CTRP2 -10.6904 3.2436 -11.5374 78.9862
EB1 CTRP2 -10.6003 -0.8726 -10.8019 85.1797
OCI-AML-3 CTRP2 -10.3666 -8.7507 -10.3666 99.3201
MOTN-1 CTRP2 -10.3389 1.9481 -10.9064 80.4091
OPM-2 CTRP2 -10.3261 -8.5252 -10.3261 99.0492
GA-10 CTRP2 -10.2805 -6.8042 -10.2806 96.1889
MOLT-3 CTRP2 -10.2798 -9.2405 -10.2798 99.81
KMS-28BM CTRP2 -10.1565 5.0307 -11.3699 76.0964
Mono-Mac-1 CTRP2 -10.1172 7.3264 -11.9593 73.5272
Namalwa CTRP2 -10.0917 -3.6342 -10.1159 89.9025
MHH-CALL-4 CTRP2 -10.0741 2.5158 -10.7236 79.2789
OCI-Ly19 CTRP2 -10.0152 -2.3311 -10.0854 87.3197
JeKo-1 CTRP2 -10.0055 -5.9599 -10.0061 94.4803
BL-70 CTRP2 -9.97 -6.0392 -9.9705 94.6221
697 CTRP2 -9.9145 -6.7505 -9.9145 95.9994
RS4;11 CTRP2 -9.8531 -6.5795 -9.8534 94.9896
ST486 CTRP2 -9.8482 -6.2883 -9.8483 95.0628
KMS-12-BM CTRP2 -9.8061 -7.3114 -9.8061 97.0496
Pfeiffer CTRP2 -9.7463 -2.1691 -9.8164 86.7629
SU-DHL-8 CTRP2 -9.7025 -1.9467 -9.7831 86.2961
TALL-1 [Human adult T-ALL] CTRP2 -9.6431 12.2189 -13.0852 68.7237
SU-DHL-6 CTRP2 -9.643 -4.7827 -9.6467 91.8813
K-562 CTRP2 -9.6364 -0.6098 -9.8133 83.7674
MOLT-13 CTRP2 -9.5236 0.6253 -9.8307 81.5124
HPB-ALL CTRP2 -9.4883 -5.9558 -9.4886 94.1763
AMO1 CTRP2 -9.4687 -7.1325 -9.4687 96.5691
Kasumi-1 CTRP2 -9.4418 0.0659 -9.6768 82.3535
PL21 CTRP2 -9.4203 -6.7025 -9.4203 95.6638
OCI-Ly3 CTRP2 -9.3978 -0.9182 -9.5365 84.0436
KMS-18 CTRP2 -9.1568 1.9385 -9.6314 78.9297
KMS-11 CTRP2 -9.0681 1.8509 -9.5217 78.9363
SKM-1 CTRP2 -9.0599 -7.7324 -9.0599 97.5113
NB4 CTRP2 -9.019 -8.0922 -9.019 98.2238
JJN-3 CTRP2 -9.0172 -5.2047 -9.0178 92.1595
KMS-34 CTRP2 -8.9913 -7.7338 -8.9913 97.4411
BV-173 CTRP2 -8.7003 -7.2263 -8.7003 95.9308
M-07e CTRP2 -8.5656 -2.2771 -8.6001 85.5193
Peer CTRP2 -8.5184 -7.6412 -8.5184 96.2688
Karpas-299 CTRP2 -8.3527 -4.9464 -8.353 90.5991
KE-37 CTRP2 -8.3135 -7.5519 -8.3135 95.3272
RPMI-8402 CTRP2 -8.2859 -7.173 -8.2859 94.6871
F-36P CTRP2 -8.229 5.3074 -9.3377 72.8823
SU-DHL-10 CTRP2 -8.1585 -7.2651 -8.1585 94.2732
LP-1 CTRP2 -8.1083 3.9483 -8.8832 74.3653
MOLM-16 CTRP2 -8.104 -6.0064 -8.104 92.0938
L-540 CTRP2 -8.0849 -6.5837 -8.0849 93.0238
L-363 CTRP2 -7.8952 -6.571 -7.8952 92.2396
Ri-1 CTRP2 -7.8604 0.5261 -8.0552 79.0836
SR CTRP2 -7.8497 -4.5999 -7.85 88.7678
EoL-1 CTRP2 -7.7113 -4.8063 -7.7114 88.7599
Reh CTRP2 -7.6483 -6.1588 -7.6483 90.6186
RCH-ACV CTRP2 -7.585 -5.5879 -7.585 89.6024
KM-H2 CTRP2 -7.5414 -5.6079 -7.5414 89.4506
MOLT-16 CTRP2 -7.451 -6.3487 -7.451 89.749
Daudi CTRP2 -7.448 -3.4471 -7.4502 85.5185
PF-382 CTRP2 -7.2996 -5.3904 -7.2996 88.106
NU-DUL-1 CTRP2 -7.2771 -6.0532 -7.2771 88.5749
OCI-AML-2 CTRP2 -7.2642 -6.2241 -7.2642 88.5782
NOMO-1 CTRP2 -7.219 -0.8361 -7.2788 80.1049
SEM CTRP2 -7.1484 -4.9067 -7.1484 86.8345
RL CTRP2 -7.0801 -0.581 -7.1493 79.3069
NCO2 CTRP2 -7.0451 -4.8246 -7.0451 86.2659
DND-41 CTRP2 -6.9539 2.0473 -7.2834 74.6858
SU-DHL-4 CTRP2 -6.9027 -5.5353 -6.9027 86.1074
Kasumi-2 CTRP2 -6.798 0.3677 -6.9227 76.9599
P12-Ichikawa CTRP2 -6.7508 -5.5254 -6.7508 85.1741
CML-T1 CTRP2 -6.7501 -5.1547 -6.7501 85.015
P3HR-1 CTRP2 -6.7271 3.2792 -7.2476 72.3888
ALL-SIL CTRP2 -6.7234 -4.3032 -6.7234 84.1605
U-937 CTRP2 -6.6719 -3.6656 -6.6721 91.5859
RPMI-8226 CTRP2 -6.6643 -4.9526 -6.6643 84.4035
Raji CTRP2 -6.6424 -5.4335 -6.6424 84.4682
U266B1 CTRP2 -6.5852 -5.4488 -6.5852 84.1061
EM-2 CTRP2 -6.527 -5.7859 -6.527 83.7507
HEL 92.1.7 CTRP2 -6.4932 -0.5082 -6.5473 77.558
Ku812 CTRP2 -6.4823 0.2607 -6.5842 76.2679
P31/FUJ CTRP2 -6.4659 -5.9114 -6.4659 83.3451
A3/Kawakami CTRP2 -6.4243 -5.9388 -6.4243 83.0683
OCI-AML-5 CTRP2 -6.422 -6.0405 -6.422 83.0533
SIG-M5 CTRP2 -6.4153 -5.9357 -6.4153 81.7957
JVM-3 CTRP2 -6.3989 -3.5849 -6.3991 81.8209
SUP-M2 CTRP2 -6.3847 -5.801 -6.3847 82.804
ME1 CTRP2 -6.3414 16.6019 -11.3193 61.0303
KMS-21-BM CTRP2 -6.3327 -5.2829 -6.3327 82.445
NALM-6 CTRP2 -6.3247 -5.4703 -6.3247 82.4017
HL-60 CTRP2 -6.3239 -5.7468 -6.3239 82.3992
JURL-MK1 CTRP2 -6.3113 -5.5314 -6.3113 82.3138
KMS-26 CTRP2 -6.3054 -5.6947 -6.3054 82.2761
NU-DHL-1 CTRP2 -6.2926 -1.3099 -6.3122 78.2038
MOLP-2 CTRP2 -6.2805 22.9714 -14.0498 58.7306
Jurkat CTRP2 -6.2746 -5.5632 -6.2746 82.0702
MJ CTRP2 -6.2706 -1.7587 -6.2808 78.8176
MOLM-13 CTRP2 -6.2674 -5.2254 -6.2674 82.0125
CMK CTRP2 -6.2528 -4.7153 -6.2528 81.8298
RPMI-6666 CTRP2 -6.2503 -4.3118 -6.2503 81.6443
HuNS1 CTRP2 -6.2425 -3.9256 -6.2425 81.345
SET-2 CTRP2 -6.2377 -0.378 -6.2905 76.545
HDLM-2 CTRP2 -6.2051 8.4861 -8.0623 65.6
DEL CTRP2 -6.1363 -5.5251 -6.1363 81.1493
WSU-DLCL2 CTRP2 -6.0117 -5.2881 -6.0117 80.3193
HT CTRP2 -5.9848 -5.2085 -5.9848 80.1399
SU-DHL-1 CTRP2 -5.944 -4.7172 -5.944 79.8522
HEL CTRP2 -5.941 -4.6093 -5.941 79.8212
KCL-22 CTRP2 -5.9197 -4.357 -5.9197 79.6418
MV4-11 CTRP2 -5.8196 -4.8057 -5.8196 79.0363
LAMA-84 CTRP2 -5.7506 -4.6946 -5.7506 78.5761
JVM-2 CTRP2 -5.4501 4.2942 -6.069 67.6804
DoHH2 CTRP2 -5.4436 -3.9173 -5.4436 76.5057
KE-97 CTRP2 -5.4158 -4.8485 -5.4158 76.3497
L-428 CTRP2 -4.8828 3.6986 -5.332 66.4997
SUP-HD1 CTRP2 -4.8095 1.4347 -4.9316 68.7766
Ci-1 CTRP2 -4.7354 1.0464 -4.8215 68.904
Ki-JK CTRP2 -4.5166 0.4531 -4.5587 68.527
KHM-1B CTRP2 -4.401 4.4798 -4.969 64.0057
TF-1 CTRP2 -3.909 8.7174 -5.6499 59.2635
KMS-27 CTRP2 -3.7812 9.4994 -5.7872 58.457
THP-1 CTRP2 -3.7279 1.3409 -3.7937 71.543
EHEB CTRP2 -3.4667 3.2342 -3.7252 61.1445
Karpas-422 CTRP2 -3.4222 3.6401 -3.7437 60.6534
AML-193 CTRP2 -2.8888 16.2925 -7.6171 53.8479
OCI-M1 CTRP2 -2.4591 15.1382 -7.0937 51.4633
MM1.S CTRP2 -1.9754 7.473 -3.1358 57.4397
HD-MY-Z CTRP2 -1.8898 8.6499 -3.4437 51.8692
Mono-Mac-6 CTRP2 -0.514 25.9186 -9.7755 48.0949
MHH-CALL-3 CTRP2 -0.3061 455.6694 -224.0818 49.8609
SK-MM-2 CTRP2 0.4065 138.9662 -66.4434 48.8731
OCI-Ly10 CTRP2 1.0465 10.1461 -0.8955 38.1614
KMS-20 CTRP2 2.2582 7.7218 1.3579 28.3126
NCI-H929 CTRP2 2.5262 3.4752 2.5259 23.4396
L-1236 CTRP2 3.9959 7.8624 3.1422 19.4199
REC-1 CTRP2 5.0295 6.0509 4.935 7.0923
Karpas-620 CTRP2 5.5724 6.3797 5.4106 3.7424
MC116 CTRP2 7.0129 7.8598 5.7619 0.2001
⏷ Show the Full List of 150 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE8 CTRP2 -7.3079 10.3704 -10.4905 63.9872
TE15 CTRP2 -0.1236 354.2034 -173.2014 49.7928
TE-4 CTRP2 -9.2691 23.3417 -18.1014 61.1359
TE-6 CTRP2 -8.1465 2.7349 -8.9203 73.514
OE21 CTRP2 -6.0961 6.0456 -7.2052 67.5754
TE-10 CTRP2 -5.2273 11.8289 -8.2083 61.0928
TE-11 CTRP2 -4.5965 11.492 -7.4056 59.7425
TE-9 CTRP2 -4.0935 0.9476 -4.1481 65.9965
KYSE-180 CTRP2 -3.912 -0.4141 -3.9181 65.9168
KYSE-510 CTRP2 -3.5049 1.3069 -3.5601 62.646
TE-5 CTRP2 -3.0187 12.0604 -5.9548 55.1535
KYSE-410 CTRP2 -1.3231 14.9072 -5.4046 49.5705
KYSE-150 CTRP2 -1.0218 9.8659 -2.9662 48.1308
EC-GI-10 CTRP2 -0.1109 229.557 -110.8818 49.6773
KYSE-70 CTRP2 -0.0652 8.4129 -1.3924 47.9576
KYSE-30 CTRP2 0.6551 6.68 -0.0223 37.7608
KYSE-140 CTRP2 0.8195 9.6967 -0.9479 39.0466
TE-14 CTRP2 1.3789 18.2147 -4.2618 41.4884
OE33 CTRP2 1.7196 7.1759 0.9735 31.2616
COLO 680N CTRP2 1.8583 14.1915 -1.8866 37.3303
KYSE-520 CTRP2 2.5054 10.0118 0.673 29.7113
KYSE-450 CTRP2 3.4732 15.9572 -1.1896 31.7445
OE19 CTRP2 4.1289 6.2548 3.8929 13.5954
TE-1 CTRP2 4.2 7.2837 3.5964 16.7628
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 38 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 3.4963 12.2729 0.6157 27.1149
PSN1 CTRP2 -9.5574 13.871 -13.6143 67.4963
Panc 03.27 CTRP2 -7.1908 5.2486 -8.1902 70.9583
MIA PaCa-2 CTRP2 -6.6503 2.7624 -7.0714 72.912
L3.3 CTRP2 -6.5809 3.4813 -7.1284 76.2971
PANC-1 CTRP2 -6.0214 11.583 -8.9631 62.9906
KP-4 CTRP2 -4.5681 0.2377 -4.602 68.984
KP-3 CTRP2 -2.8843 5.5046 -3.5578 57.1184
Panc 08.13 CTRP2 -2.1664 7.1908 -3.2537 53.3203
QGP-1 CTRP2 -2.0416 13.8962 -5.7003 51.8401
Panc 10.05 CTRP2 -1.6412 9.9901 -3.6743 50.7333
DAN-G CTRP2 -1.5741 9.3965 -3.3769 50.4806
BxPC-3 CTRP2 -0.4557 10.3837 -2.5715 45.7138
PaTu 8988s CTRP2 0.9234 80.684 -35.6244 48.3645
SU.86.86 CTRP2 1.0297 7.9624 -0.7519 30.2041
CFPAC-1 CTRP2 1.0805 7.0725 0.3151 35.3471
SW1990 CTRP2 1.0848 12.043 -1.6772 39.3425
PaTu 8988t CTRP2 1.3516 7.366 0.5096 33.8677
Hs 766T CTRP2 2.4524 4.5879 2.4053 24.0894
HuP-T4 CTRP2 2.5097 5.1695 2.3857 27.692
SNU-213 CTRP2 2.5295 4.2144 2.514 23.4687
PK-45H CTRP2 2.5464 6.9687 1.9398 25.4324
HPAC CTRP2 2.6311 3.6288 2.6306 26.2738
PK-59 CTRP2 3.056 5.9583 2.8062 24.003
TCC-Pan2 CTRP2 3.1809 15.784 -1.3781 36.0122
Panc 05.04 CTRP2 3.2214 5.5686 3.0793 22.2927
Capan-2 CTRP2 3.2939 7.8029 2.4299 21.4683
PaTu 8902 CTRP2 3.3084 9.4033 1.7626 27.303
YAPC CTRP2 3.4755 5.961 3.2632 20.6267
AsPC-1 CTRP2 3.8362 21.4983 -3.5921 35.0642
KP-2 CTRP2 4.246 5.6731 4.1693 12.2443
HPAF-II CTRP2 4.4531 19.9415 -2.2711 31.627
Panc 04.03 CTRP2 4.6213 9.1451 3.1922 15.0325
SNU-410 CTRP2 4.7487 6.1169 4.61 9.1198
SUIT-2 CTRP2 4.8571 15.8035 0.1432 25.1876
HuP-T3 CTRP2 4.9331 18.6604 -1.212 28.4438
Panc 02.03 CTRP2 5.5611 21.5164 -2.0979 29.0319
Capan-1 CTRP2 7.7657 40.1489 -9.5955 35.1324
⏷ Show the Full List of 38 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 1.5931 2.4058 1.593 24.6344
WM983B CTRP2 -8.2443 24.4003 -16.6808 60.999
Hs 294T CTRP2 -6.6437 4.34 -7.3771 70.8229
MDA-MB-435S CTRP2 -6.2718 4.5906 -7.0293 73.9614
HMCB CTRP2 -6.2276 0.1785 -6.3129 75.6346
RPMI-7951 CTRP2 -5.3584 3.8109 -5.8689 67.9453
Hs 944.T CTRP2 -4.8683 3.1079 -5.2109 67.0927
IGR-37 CTRP2 -4.4806 0.8666 -4.5442 67.9491
Mel JuSo CTRP2 -4.3258 2.0547 -4.4847 66.0596
IGR-1 CTRP2 -2.795 2.7657 -2.9445 57.9832
K029AX CTRP2 -2.3269 3.958 -2.6181 54.9809
LOX-IMVI CTRP2 -1.9221 4.1509 -2.2156 52.691
MeWo CTRP2 -1.5676 7.9551 -2.8533 50.4979
Hs 936.T CTRP2 -1.3018 4.298 -1.5724 55.5802
A101D CTRP2 -1.0794 4.117 -1.3013 47.6648
Hs 852.T CTRP2 -0.37 6.4387 -1.0674 49.5089
COLO 800 CTRP2 -0.3337 6.6182 -1.081 43.7936
A-375 CTRP2 0.0612 138.2127 -65.0897 49.3956
IPC-298 CTRP2 0.2763 4.1954 0.141 44.69
SK-MEL-5 CTRP2 0.3399 4.991 0.0716 44.4593
COLO 741 CTRP2 0.466 21.1274 -6.5335 45.1479
WM793 CTRP2 0.7894 4.9482 0.5673 41.0847
SK-MEL-1 CTRP2 0.9915 5.7739 0.6015 34.8714
COLO 829 CTRP2 1.2938 14.2288 -2.4612 39.7929
COLO 792 CTRP2 1.4872 2.8693 1.4863 30.3638
WM266-4 CTRP2 1.531 9.3262 -0.0476 34.712
Hs 934.T CTRP2 2.1455 5.0554 2.0129 26.4256
Mel Ho CTRP2 2.259 6.2688 1.8499 26.6319
SK-MEL-24 CTRP2 2.3894 3.5133 2.3886 24.3529
G-361 CTRP2 2.3922 4.7802 2.3193 28.3944
Hs 940.T CTRP2 2.3952 3.2122 2.3951 24.3119
UACC-257 CTRP2 2.4044 4.4374 2.3689 24.3695
RVH-421 CTRP2 2.4261 2.9189 2.4261 24.1053
SK-MEL-3 CTRP2 2.4341 2.8862 2.4341 24.0521
HT-144 CTRP2 2.4415 15.9274 -2.1472 36.1569
Hs 688(A).T CTRP2 2.5249 2.9885 2.5249 23.4475
SK-MEL-30 CTRP2 2.5718 2.9072 2.5718 26.7283
Hs 839.T CTRP2 2.6373 4.6837 2.5905 22.8566
WM1799 CTRP2 2.7639 3.2473 2.7639 25.25
Malme-3M CTRP2 3.0837 5.6948 2.9016 20.3539
SK-MEL-28 CTRP2 3.9092 4.4608 3.9091 16.4346
Hs 895.T CTRP2 3.9477 10.1867 2.043 21.1584
SK-MEL-31 CTRP2 4.0381 5.0677 4.0253 15.4919
UACC-62 CTRP2 5.1665 6.0455 5.086 6.1305
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 CTRP2 -5.0907 10.375 -7.5148 61.6001
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-AS CTRP2 -13.5356 6.0478 -15.3248 78.3927
NH-6 CTRP2 -12.0729 10.3732 -15.0587 73.0619
SK-N-DZ CTRP2 -10.6419 -3.4822 -10.6806 89.955
CHP-126 CTRP2 -9.8895 3.3383 -10.6877 77.9053
Kelly CTRP2 -8.1382 -7.0116 -8.1382 93.8661
NB1 CTRP2 -7.0998 -6.1352 -7.0998 87.5271
KP-N-SI9s CTRP2 -6.7825 6.3726 -8.045 68.8469
CHP-212 CTRP2 -6.2579 -4.6408 -6.2579 81.8372
MHH-NB-11 CTRP2 -6.0386 -3.7771 -6.0386 80.1109
SiMa CTRP2 -5.7727 -0.1622 -5.8221 74.6087
SK-N-SH CTRP2 -4.33 2.5803 -4.5541 65.5552
SK-N-BE(2) CTRP2 -4.2229 8.2038 -5.8167 60.5468
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-478 CTRP2 -5.7551 -3.2345 -5.7551 78.1582
HuCC-T1 CTRP2 0.3187 7.394 -0.6187 40.3265
SNU-1196 CTRP2 1.1147 12.0509 -1.6502 39.2053
SNU-1079 CTRP2 1.4189 4.0098 1.3731 30.9685
SNU-869 CTRP2 1.8131 7.1879 1.0706 30.6524
HuH-28 CTRP2 2.6497 3.8125 2.648 22.6214
SNU-308 CTRP2 3.6579 6.506 3.3007 17.1701
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-673 CTRP2 -10.9309 -4.129 -10.9565 91.3142
SK-N-MC CTRP2 -6.4473 -6.0711 -6.4473 83.2218
SK-ES-1 CTRP2 -6.4107 -5.7718 -6.4107 82.9772
TC71 CTRP2 -6.342 -5.9546 -6.342 82.5201
MG-63 CTRP2 -4.9665 38.653 -20.1492 54.3521
SJSA-1 CTRP2 -4.1178 3.8499 -4.8035 59.1315
U2OS CTRP2 -3.9777 7.0807 -5.1926 60.4752
HOS CTRP2 -3.6263 1.2334 -3.6814 63.3501
SW1353 CTRP2 -2.4321 2.9697 -2.5838 55.8747
G-292 clone A141B1 CTRP2 -1.5707 21.4686 -8.6667 50.2517
SaOS-2 CTRP2 -1.1847 6.7749 -2.0559 48.5732
CAL-78 CTRP2 2.1372 9.2457 0.6211 30.9811
Hs 888.T CTRP2 2.3964 3.4166 2.3961 24.3045
Hs 822.T CTRP2 2.5233 2.8525 2.5233 23.458
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 66 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC1806 CTRP2 -10.3336 22.6022 -18.0268 64.1112
MDA-MB-468 CTRP2 -8.8445 4.672 -9.8512 74.677
DU4475 CTRP2 -6.4048 -5.8445 -6.4048 82.9384
MDA-MB-157 CTRP2 -6.1609 18.2766 -11.8477 60.0481
Hs 578T CTRP2 -5.8561 8.0453 -7.5397 65.1454
HCC1395 CTRP2 -4.962 8.2284 -6.6275 62.6888
CAL-51 CTRP2 -4.9174 3.2487 -5.2876 67.1119
AU565 CTRP2 -4.7465 14.6097 -8.8181 58.7142
HMC-1-8 CTRP2 -4.0693 -1.2855 -4.0702 67.2068
HCC38 CTRP2 -3.996 16.2833 -8.7505 56.4778
SK-BR-3 CTRP2 -2.8128 11.428 -5.4836 54.689
HCC1954 CTRP2 -1.4905 7.356 -2.5709 50.1451
BT-20 CTRP2 -0.3223 108.1495 -50.4062 49.4247
MDA-MB-453 CTRP2 -0.2268 13.1887 -3.5241 45.5113
MDA-MB-231 CTRP2 -0.1396 8.2586 -1.4165 43.3938
JIMT-1 CTRP2 -0.0889 8.7431 -1.5403 43.3382
BT-549 CTRP2 -0.009 42.019 -17.2071 48.1275
HCC1143 CTRP2 0.1565 10.9957 -2.1814 47.2994
CAL-148 CTRP2 0.4985 11.5812 -2.0763 41.8189
MCF-7 CTRP2 0.9631 11.1767 -1.4217 39.3463
MDA-MB-361 CTRP2 1.0976 12.0434 -1.6643 39.2817
HDQ-P1 CTRP2 1.4223 16.0946 -3.2095 40.3266
HCC1500 CTRP2 2.1306 2.9809 2.1306 26.0742
HCC1428 CTRP2 2.7433 3.5097 2.7432 21.9926
BT-474 CTRP2 2.8344 4.1475 2.8288 21.4041
T-47D CTRP2 2.8791 4.6907 2.8444 21.2045
KPL-1 CTRP2 3.2527 4.7577 3.2298 18.6755
ZR-75-30 CTRP2 3.6179 6.2721 3.3308 17.1786
CAMA-1 CTRP2 3.8031 5.7033 3.6824 15.348
HCC2218 CTRP2 3.923 5.8141 3.7879 14.6006
HCC1937 CTRP2 4.1536 11.2886 1.7178 21.8206
HCC202 CTRP2 4.3493 12.9291 1.1042 23.4408
ZR-75-1 CTRP2 7.2106 9.6037 5.1172 2.4705
BT 145 CTRP2 -6.4311 6.0716 -7.5779 68.3598
BT 428 CTRP2 -4.1729 10.3851 -6.5329 59.1694
BT147 CTRP2 -3.5779 6.7651 -4.662 59.2562
BT 504 CTRP2 -3.4391 2.8212 -3.6364 61.2996
BT 245 CTRP2 -3.199 6.4005 -4.1427 58.0023
BT 131 CTRP2 -2.4588 7.3918 -3.6354 54.5397
BT 286 CTRP2 -1.4616 5.1576 -1.9231 50.0052
BT 172 CTRP2 -0.8903 7.4624 -1.9534 47.1287
BT164 CTRP2 -0.6902 133.2997 -63.279 49.6845
BT 179 CTRP2 -0.5989 5.4353 -1.0488 44.9693
BT 231 CTRP2 -0.5548 20.3307 -7.1381 47.7354
BT 359 CTRP2 -0.3152 11.0315 -2.6895 45.2727
BT 333 CTRP2 -0.2024 6.5568 -0.9195 42.9906
BT 159 CTRP2 -0.1929 12.8865 -3.3565 45.2966
BT 239 CTRP2 0.8201 8.6921 -0.5487 38.2917
BT 248 CTRP2 1.157 6.2567 0.6511 34.1414
BT 482 CTRP2 1.4397 8.5653 0.1607 34.4988
BT 187 CTRP2 1.5597 6.8801 0.8988 32.0214
BT 139 CTRP2 1.8302 10.7004 -0.3218 34.3947
BT 271 CTRP2 2.021 6.293 1.5832 28.2993
BT 416 CTRP2 2.4814 9.5183 0.8632 29.2113
BT 232 CTRP2 2.5044 2.9503 2.5044 23.5837
BT 228 CTRP2 2.5561 4.5319 2.5196 23.3623
BT 216 CTRP2 2.5602 8.3274 1.4435 27.1095
BT 440 CTRP2 2.732 7.216 2.0533 24.4718
BT 224 CTRP2 3.321 12.7179 0.2344 28.6747
BT 444 CTRP2 3.5378 6.6064 3.1371 18.1286
BT 422 CTRP2 4.368 9.2269 2.9058 16.7947
BT 330 CTRP2 4.4663 6.2648 4.2573 11.2539
BT 340 CTRP2 4.5819 5.3058 4.5743 9.7689
BT 320 CTRP2 4.9678 6.0617 4.8648 7.5333
BT 498 CTRP2 4.9703 5.9235 4.9029 7.389
BT 328 CTRP2 9.2072 22.2647 0.3951 16.4749
⏷ Show the Full List of 66 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 0.4237 7.5574 -0.5606 39.8046
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KNS-60 CTRP2 -9.717 -0.7026 -9.9913 82.0287
Hs 683 CTRP2 -8.37 3.7343 -9.1213 75.1103
AM-38 CTRP2 -7.0236 4.3032 -7.7821 71.7391
D283 Med CTRP2 -6.3092 -4.9298 -6.3092 82.2413
Daoy CTRP2 -5.9581 -4.2971 -5.9581 79.8692
LN-18 CTRP2 -5.7011 3.326 -6.1471 69.5733
SF539 CTRP2 -4.5152 -0.166 -4.5342 69.0898
YH-13 CTRP2 -4.4543 1.5216 -4.5666 67.1641
KALS-1 CTRP2 -2.8225 7.8804 -4.1895 55.8492
LN-229 CTRP2 -2.5168 3.1007 -2.6905 56.3093
A-172 CTRP2 -2.1892 5.4241 -2.7797 53.8501
SF268 CTRP2 -2.1432 6.6311 -3.0578 53.3384
YKG-1 CTRP2 -1.5775 24.5144 -10.1171 50.238
Becker CTRP2 -0.9994 62.6657 -28.3312 49.6042
ONS-76 CTRP2 -0.9716 4.6566 -1.2829 47.0734
GaMG CTRP2 -0.7955 7.0869 -1.7288 51.9014
SF126 CTRP2 -0.5049 4.7439 -0.7946 44.1722
U-251MG CTRP2 0.0244 8.4171 -1.2978 42.5796
42-MG-BA CTRP2 0.0777 12.9792 -3.1201 44.239
U-118MG CTRP2 0.1848 19.5866 -6.0673 45.6135
CAS-1 CTRP2 0.2848 12.3097 -2.6134 43.1165
SNU-738 CTRP2 0.5693 13.8247 -3.0002 42.5762
SNB-75 CTRP2 0.7016 9.1082 -0.8368 39.271
DBTRG-05MG CTRP2 0.9359 10.7633 -1.2719 39.1961
8-MG-BA CTRP2 0.9791 21.127 -6.0449 43.7277
SNU-1105 CTRP2 1.2596 6.6204 0.6546 33.7729
KG-1-C CTRP2 2.0415 7.3995 1.2432 29.3667
SNU-626 CTRP2 2.3287 7.5323 1.5041 27.6057
SW1088 CTRP2 2.444 10.1826 0.5349 34.2217
CCF-STTG1 CTRP2 2.6782 21.9246 -4.8501 39.031
KNS-81 CTRP2 2.753 4.3449 2.5534 11.0403
SNU-489 CTRP2 2.7614 8.5815 1.5513 26.1494
SNU-466 CTRP2 2.8742 3.5125 2.8742 21.1201
T98G CTRP2 3.1414 6.0488 2.8751 20.271
SW1783 CTRP2 3.1848 6.2743 2.8579 20.2013
NMC-G1 CTRP2 3.5108 5.8403 3.3323 17.4988
SNU-201 CTRP2 3.8214 5.4868 3.7447 15.0719
SF295 CTRP2 4.0781 15.8833 -0.5965 28.9298
GB-1 CTRP2 4.1569 14.0322 0.3859 26.1241
U-87MG ATCC CTRP2 5.8294 15.7207 1.026 20.412
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHUEM-7 CTRP2 -10.6591 8.9911 -13.0668 72.6342
AN3-CA CTRP2 -7.9598 4.2364 -8.7858 73.7187
MFE-319 CTRP2 -6.2449 5.4739 -7.2158 68.5452
JHUEM-2 CTRP2 -5.3521 -3.94 -5.3521 75.9095
HEC-151 CTRP2 -3.9458 8.6275 -5.6589 63.5036
HEC-50B CTRP2 -3.5927 17.683 -8.9518 55.2264
HEC-59 CTRP2 -3.2357 6.7296 -4.2784 57.9754
MFE-296 CTRP2 -3.2236 5.1233 -3.8342 58.8161
JHUEM-1 CTRP2 -2.6989 5.8164 -3.4362 56.1469
HEC-1-A CTRP2 -2.6782 9.8127 -4.7163 54.68
JHUEM-3 CTRP2 -2.3658 13.5774 -5.9002 52.8645
RL95-2 CTRP2 -1.8227 4.7156 -2.2183 52.0523
KLE CTRP2 -1.7242 10.3934 -3.9195 51.0387
HEC-6 CTRP2 -1.2938 6.6694 -2.143 49.137
ESS-1 CTRP2 0.3871 10.8607 -1.8841 41.9716
HEC-1-B CTRP2 1.1747 10.4468 -0.889 37.7148
HEC-265 CTRP2 1.6878 37.7843 -13.5879 45.3039
EFE-184 CTRP2 1.7644 9.5852 0.0895 37.8672
EN CTRP2 2.3587 3.2274 2.3586 24.5548
HEC-108 CTRP2 3.1788 4.6713 3.1591 19.1568
HEC-251 CTRP2 4.887 16.6601 -0.2564 26.2126
Ishikawa (Heraklio) 02 ER- CTRP2 -5.2279 -4.753 -5.2279 75.0976
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BFTC-909 CTRP2 -6.1315 4.4377 -6.8418 69.428
TUHR4TKB CTRP2 -2.9301 8.0179 -4.3518 56.2091
KMRC-3 CTRP2 -2.5477 4.8814 -3.0423 55.8046
TUHR10TKB CTRP2 -1.7984 7.9081 -3.0875 51.5536
VMRC-RCW CTRP2 -0.9429 6.4148 -1.6853 52.828
VMRC-RCZ CTRP2 -0.5942 7.3028 -1.5794 45.5086
UO-31 CTRP2 0.0611 6.9497 -0.7533 41.6084
KMRC-1 CTRP2 0.6263 7.3446 -0.2685 38.4285
769-P CTRP2 0.9798 14.7815 -3.0289 41.3758
786-O CTRP2 1.511 9.0435 0.0463 34.5478
CAL-54 CTRP2 1.7875 10.633 -0.3361 34.5622
RCC10RGB CTRP2 2.1498 4.8654 2.0483 26.2905
KMRC-2 CTRP2 2.2539 3.2202 2.2537 25.2535
KMRC-20 CTRP2 2.8629 5.06 2.7831 21.4668
SNU-1272 CTRP2 3.2177 13.737 -0.353 30.4843
OS-RC-2 CTRP2 4.3254 8.3306 3.2754 15.4384
TUHR14TKB CTRP2 4.5502 6.8855 4.1261 24.6319
A-498 CTRP2 4.9188 9.3769 3.3672 13.6178
ACHN CTRP2 4.9758 12.0059 2.1322 18.3588
Caki-1 CTRP2 6.587 15.3623 1.8295 16.1606
Caki-2 CTRP2 6.8933 22.4786 -1.4764 25.2123
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
GP2d CTRP2 -10.3092 9.5333 -12.8643 71.7175
CCK-81 CTRP2 -9.695 3.594 -10.5308 77.3069
NCI-H508 CTRP2 -7.7076 9.4805 -10.0249 67.8056
KM12 CTRP2 -6.8967 17.4358 -12.2503 61.6149
SW48 CTRP2 -6.7188 -4.9296 -6.7188 84.6974
CW-2 CTRP2 -6.5321 12.1905 -9.7399 63.6531
SNU-175 CTRP2 -6.263 -4.629 -6.263 81.8646
HT115 CTRP2 -5.8303 -4.8443 -5.8303 79.1082
T84 CTRP2 -5.5421 0.0905 -5.5973 73.388
CL-11 CTRP2 -5.1248 12.3387 -8.2974 60.5878
RKO CTRP2 -4.3409 6.2565 -5.3481 62.2919
NCI-H716 CTRP2 -4.3017 9.4813 -6.3419 60.0187
LS180 CTRP2 -4.2799 -1.4762 -4.2806 68.5709
SNU-81 CTRP2 -4.0066 6.0183 -4.9174 61.3129
LS513 CTRP2 -3.7733 0.1087 -3.7869 64.8456
HCT 15 CTRP2 -3.6636 1.0297 -3.7085 63.6846
SK-CO-1 CTRP2 -3.3991 6.1202 -4.2824 58.9557
SNU-C2A CTRP2 -3.1802 9.2953 -5.0661 56.599
LS1034 CTRP2 -3.1242 3.9125 -3.4705 59.0754
LoVo CTRP2 -2.2257 6.7721 -3.1897 58.9352
COLO 320 CTRP2 -2.1019 13.1548 -5.4463 52.1061
SNU-407 CTRP2 -1.9058 8.268 -3.3269 56.7394
SNU-61 CTRP2 -1.7786 8.6545 -3.3253 56.0423
SW1463 CTRP2 -1.4705 10.6759 -3.762 50.0388
SNU-C4 CTRP2 -0.2583 8.0067 -1.4545 43.9289
SNU-1033 CTRP2 -0.2384 12.4045 -3.1932 45.3447
DLD-1 CTRP2 -0.0984 9.9287 -2.0108 43.8866
SNU-503 CTRP2 -0.0061 3169.3817 -1580.6691 49.9748
SNU-C5 CTRP2 0.5912 11.6817 -2.0243 45.4574
SW620 CTRP2 0.7349 38.9626 -15.0249 48.315
COLO205 CTRP2 0.9121 19.034 -5.1021 43.3037
SW1417 CTRP2 1.0076 10.2674 -0.9872 38.4622
HT-55 CTRP2 1.0452 7.6763 0.0697 40.9467
HCT 8 CTRP2 1.589 5.6524 1.2833 30.7021
C2BBe1 CTRP2 1.592 6.8352 0.9484 31.761
RCM-1 [Human ESC] CTRP2 1.8898 8.0116 0.8541 31.074
NCI-H747 CTRP2 2.1751 4.6187 2.1085 26.0027
OUMS-23 CTRP2 2.4322 4.0021 2.4231 24.0955
LS123 CTRP2 2.4619 8.332 1.3376 31.7542
COLO201 CTRP2 2.8192 10.141 0.9358 27.9982
MDST8 CTRP2 2.8247 3.9543 2.8228 24.7891
HT-29 CTRP2 3.3105 6.0846 3.0497 19.1264
HCT 116 CTRP2 3.4373 8.4597 2.3075 21.5259
LS411N CTRP2 4.0841 5.4084 4.0392 13.212
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-5 CTRP2 -9.7949 16.7245 -14.9936 66.147
SNU-398 CTRP2 -6.3047 27.174 -15.9983 57.7297
Li-7 CTRP2 -5.3025 4.8976 -6.0456 66.5868
SNU-878 CTRP2 -5.0802 -3.4049 -5.0802 74.0827
SNU-423 CTRP2 -3.5791 4.8405 -4.1554 60.5069
HLF CTRP2 -2.5992 3.9879 -2.9173 56.4163
SNU-182 CTRP2 -1.4904 5.893 -2.1377 50.1594
SNU-886 CTRP2 -1.1447 47.6112 -20.9972 49.6474
JHH-4 CTRP2 -0.7514 4.6979 -1.0526 45.7169
HuH-6 CTRP2 -0.6265 3.5107 -0.7324 51.2623
Hep-G2 CTRP2 -0.561 5.3658 -0.991 50.7022
PLC/PRF/5 CTRP2 -0.4346 6.9647 -1.2975 44.5081
SNU-475 CTRP2 0.3911 6.6271 -0.2937 39.3942
SNU-761 CTRP2 0.9303 10.69 -2.1095 34.303
JHH-2 CTRP2 1.2028 14.683 -2.7622 40.4296
SNU-449 CTRP2 1.6347 5.5878 1.3485 30.3361
SK-HEP-1 CTRP2 1.6719 10.0999 -0.2249 34.6735
SNU-387 CTRP2 1.8293 10.4929 -0.232 34.1879
Hep 3B2.1-7 CTRP2 3.2745 9.0666 1.8767 23.5516
JHH-6 CTRP2 7.3469 8.1132 5.7985 0.0548
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 140 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC33 CTRP2 -11.943 4.1576 -13.1046 79.1012
COR-L51 CTRP2 -11.0801 0.1112 -11.4215 83.953
NCI-H510A CTRP2 -10.9783 -0.2482 -11.2687 84.4483
LC-1F CTRP2 -10.9426 2.6571 -11.6912 80.0483
LUDLU-1 CTRP2 -10.9123 25.2827 -19.793 63.7444
NCI-H23 CTRP2 -10.7598 -1.7045 -10.8972 86.7609
NCI-H2141 CTRP2 -10.7279 6.8612 -12.4891 74.7696
NCI-H522 CTRP2 -10.6831 2.1887 -11.3212 80.4336
NCI-H810 CTRP2 -10.3615 2.9017 -11.1101 79.0771
NCI-H1694 CTRP2 -10.1579 -1.1541 -10.3121 85.2789
DV-90 CTRP2 -9.9318 4.3874 -10.968 76.593
LCLC-97TM1 CTRP2 -9.9099 14.8017 -14.3503 67.3853
NCI-H889 CTRP2 -9.8386 10.055 -12.5293 70.6541
NCI-H2171 CTRP2 -9.7096 3.4971 -10.5259 77.4563
NCI-H661 CTRP2 -9.3667 2.5422 -9.9638 78.3259
NCI-H446 CTRP2 -8.8596 3.5142 -9.6064 76.2088
NCI-H1792 CTRP2 -8.6311 19.7001 -15.0162 63.2108
NCI-H1703 CTRP2 -8.3947 -2.7456 -8.4133 86.1818
NCI-H2081 CTRP2 -7.8723 15.0652 -12.2935 64.3301
VMRC-LCD CTRP2 -7.8666 21.2237 -14.887 61.5742
PC-14 CTRP2 -7.6479 1.2614 -8.0736 74.6852
NCI-H211 CTRP2 -7.2816 -5.2085 -7.2816 87.8048
LK2 CTRP2 -6.5074 -4.7797 -6.5074 83.397
NCI-H838 CTRP2 -6.2854 -5.6578 -6.2854 82.1428
COLO 668 CTRP2 -6.2653 46.3628 -25.1099 54.9579
NCI-H1975 CTRP2 -6.1608 9.8419 -8.4765 64.4541
NCI-H2286 CTRP2 -5.975 11.4902 -8.8784 62.9493
MOR/CPR CTRP2 -5.8868 -5.1568 -5.8868 79.4871
NCI-H1155 CTRP2 -5.576 -4.2285 -5.576 77.4006
SHP-77 CTRP2 -5.381 -4.7267 -5.381 76.1177
HCC44 CTRP2 -5.3581 3.3532 -5.7816 68.4781
NCI-H1339 CTRP2 -5.3503 3.607 -5.8204 68.1551
SBC-5 CTRP2 -5.2987 -4.682 -5.2987 75.5695
LCLC-103H CTRP2 -5.1656 -3.605 -5.1656 74.6605
NCI-H1581 CTRP2 -5.1198 1.5691 -5.2715 69.8395
NCI-H2009 CTRP2 -5.049 0.0132 -5.086 71.4544
NCI-H2122 CTRP2 -4.946 5.8046 -5.8851 64.6173
NCI-H841 CTRP2 -4.9426 8.2979 -6.6292 62.585
HARA [Human squamous cell lung carcinoma] CTRP2 -4.8355 5.8558 -5.7782 64.2283
DMS 53 CTRP2 -4.7998 5.2756 -5.5894 64.6418
EBC-1 CTRP2 -4.5462 3.9634 -5.019 70.5597
HOP-92 CTRP2 -4.463 13.152 -7.9209 58.652
NCI-H520 CTRP2 -4.3333 9.5587 -6.4036 60.0652
DMS 114 CTRP2 -4.3083 3.7767 -4.7253 64.3092
NCI-H1355 CTRP2 -4.2261 10.3965 -6.5941 59.3124
NCI-H1944 CTRP2 -4.165 10.0651 -6.406 59.3105
HCC95 CTRP2 -3.8285 10.8181 -6.3273 57.9855
RERF-LC-MS CTRP2 -3.7664 5.2849 -4.465 60.9464
Lu-99 CTRP2 -3.4215 5.0428 -4.0308 59.7119
NCI-H2087 CTRP2 -3.3308 9.1553 -5.1783 57.1657
EPLC-272H CTRP2 -3.2411 30.231 -14.4505 52.861
HCC827 CTRP2 -3.1416 6.5158 -4.1131 57.7118
A-549 CTRP2 -3.0548 7.5874 -4.3464 56.8641
SW1271 CTRP2 -2.9934 7.8399 -4.9119 52.4591
HCC1588 CTRP2 -2.9674 3.005 -3.158 58.7933
NCI-H2405 CTRP2 -2.9624 6.549 -3.9273 56.9655
HCC15 CTRP2 -2.6346 4.8569 -3.1315 56.2401
RERF-LC-A1 CTRP2 -2.5344 4.394 -2.9244 55.9236
HCC2279 CTRP2 -2.3222 4.7972 -2.7785 54.7
LXF 289 CTRP2 -2.0334 3.115 -2.178 60.6503
DMS 273 CTRP2 -1.9272 18.8888 -7.8175 51.1702
NCI-H69 CTRP2 -1.9256 6.3616 -2.7421 52.3509
NCI-H1184 CTRP2 -1.8566 5.246 -2.374 58.2029
HCC1438 CTRP2 -1.7745 7.323 -2.8691 51.5034
HCC1195 CTRP2 -1.6965 18.6779 -7.4904 50.6031
SK-LU-1 CTRP2 -1.6895 4.5176 -2.0333 57.7484
CAL-12T CTRP2 -1.5807 9.2047 -3.3125 50.5147
NCI-H1299 CTRP2 -1.5594 3.893 -1.781 50.5968
NCI-H196 CTRP2 -1.2379 5.6734 -1.8048 48.7661
Lu-65 CTRP2 -1.2036 4.9077 -1.5867 48.5036
HCC78 CTRP2 -1.0233 9.464 -2.8129 48.0884
NCI-H650 CTRP2 -1.0209 8.497 -2.4519 47.9512
NCI-H1573 CTRP2 -1.0065 38.4585 -16.3579 49.377
NCI-H2110 CTRP2 -0.8665 36.5285 -15.281 49.1412
NCI-H1385 CTRP2 -0.8464 6.9157 -1.7306 46.7844
NCI-H1650 CTRP2 -0.8324 8.614 -2.2912 47.0606
COR-L95 CTRP2 -0.5826 93.7065 -43.4247 49.4897
NCI-H2029 CTRP2 -0.5669 28.3595 -11.0091 48.3479
HCC4006 CTRP2 -0.4523 25.513 -9.521 47.9367
LOU-NH91 CTRP2 -0.4093 14.2077 -4.1628 46.4262
NCI-H1693 CTRP2 -0.3166 9.2024 -1.958 44.6845
NCI-H647 CTRP2 -0.2066 10.6261 -2.408 44.6553
NCI-H1105 CTRP2 -0.1881 361.708 -177.0074 49.8069
NCI-H209 CTRP2 -0.1753 79.0787 -37.0171 48.4357
NCI-H2228 CTRP2 -0.1716 19.9889 -7.6419 44.0961
NCI-H526 CTRP2 0.0504 16.2405 -4.627 45.2876
HOP-62 CTRP2 0.0515 8.5252 -1.3085 42.4861
Calu-6 CTRP2 0.0818 5.5675 -0.3389 46.4634
SK-MES-1 CTRP2 0.1267 24.4164 -8.4426 46.5471
NCI-H2172 CTRP2 0.1384 9.3109 -1.5151 42.4202
Calu-3 CTRP2 0.4121 7.4069 -0.5218 39.775
NCI-H322 CTRP2 0.618 17.742 -4.7719 43.8329
T3M-10 CTRP2 0.7529 7.5974 -0.2183 37.8421
NCI-H460 CTRP2 0.7639 13.748 -2.7695 41.7449
NCI-H1666 CTRP2 0.8702 10.1983 -1.1017 39.1364
EKVX CTRP2 1.0076 8.5207 -0.2828 37.057
DMS 454 CTRP2 1.0834 7.3413 0.2278 35.5652
NCI-H2023 CTRP2 1.1252 6.0003 0.6879 39.1852
COLO 699 CTRP2 1.1292 9.0674 -0.367 36.8132
NCI-H1373 CTRP2 1.2054 13.1066 -2.0338 39.4827
NCI-H524 CTRP2 1.4025 10.2015 -0.548 40.5288
NCI-H1755 CTRP2 1.4708 6.3869 0.9555 36.904
NCI-H358 CTRP2 1.6047 14.1864 -2.1339 38.4374
NCI-H1793 CTRP2 1.7019 11.3926 -0.7592 35.7515
NCI-H2030 CTRP2 1.7555 15.0959 -2.4128 38.4094
COR-L105 CTRP2 1.7989 11.4759 -0.6978 35.3218
NCI-H1435 CTRP2 1.8028 3.8051 1.7856 32.7131
NCI-H1563 CTRP2 2.1112 7.7835 1.1773 29.3605
DMS 79 CTRP2 2.3892 5.3318 2.2248 24.914
KNS-62 CTRP2 2.3955 71.098 -29.5711 46.9354
NCI-H2106 CTRP2 2.4387 9.8492 0.6757 29.9019
HCC2935 CTRP2 2.4814 5.3949 2.3121 24.3176
NCI-H226 CTRP2 2.4843 10.8181 -0.6922 25.5394
NCI-H1838 CTRP2 2.5485 8.7459 1.26 27.7539
NCI-H2342 CTRP2 2.6299 10.5374 0.5661 29.6575
NCI-H2196 CTRP2 2.7104 4.8397 2.6501 22.4156
Sq-1 CTRP2 2.7381 4.4497 2.716 25.5337
NCI-H292 CTRP2 2.8605 5.5618 2.6886 21.8039
NCI-H727 CTRP2 2.9276 4.7243 2.8922 20.8838
Calu-1 CTRP2 3.1021 10.8394 0.903 27.3028
NCI-H1623 CTRP2 3.1254 13.7743 -0.4592 30.9866
HCC366 CTRP2 3.1285 11.294 0.7187 27.7946
NCI-H2444 CTRP2 3.1447 5.5338 2.4815 10.1441
NCI-H2085 CTRP2 3.2165 5.5228 3.0834 19.297
ChaGo-K-1 CTRP2 3.2408 7.4165 2.5249 21.2655
NCI-H2291 CTRP2 3.4698 5.8341 3.2892 17.7789
NCI-H2126 CTRP2 3.8427 6.8073 3.3972 18.798
RERF-LC-Ad2 CTRP2 3.9524 8.2428 2.9335 17.7516
HCC1171 CTRP2 4.0284 6.2665 3.7798 14.3092
HCC1833 CTRP2 4.127 5.7118 4.0324 13.0997
BEN CTRP2 4.1955 5.1978 4.1799 12.37
NCI-H1395 CTRP2 4.2611 7.3993 3.6134 14.2795
HCC2108 CTRP2 4.5422 19.1921 -1.8198 30.5722
RERF-LC-Ad1 CTRP2 4.5757 7.5997 3.8551 12.4951
NCI-H2170 CTRP2 4.6684 26.2126 -5.2081 35.5014
IA-LM CTRP2 4.6711 7.0866 4.1728 10.9952
LC-1/sq-SF CTRP2 5.0325 17.7671 -0.6802 26.9773
NCI-H1869 CTRP2 5.2929 17.8692 -0.5054 25.9828
NCI-H441 CTRP2 5.6107 14.515 1.4425 19.4672
Hs 888.Lu CTRP2 2.3014 19.0308 -3.782 38.7402
⏷ Show the Full List of 140 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
H-STS CTRP2 -5.7947 -4.0384 -5.7947 78.7741
SYO-1 CTRP2 -4.3499 3.603 -4.738 64.6352
Cancer Drug Sensitivity Data Curated from 38 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 -3.5472 4.6337 -4.0745 60.5172
A2780 CTRP2 -8.7046 3.4978 -9.4347 75.986
MCAS CTRP2 -7.6089 -6.0317 -7.6089 90.2877
OVCAR-8 CTRP2 -6.5123 4.7611 -7.3312 70.0029
OC 314 CTRP2 -6.4368 -5.8697 -6.4368 83.1513
TOV-112D CTRP2 -6.4183 -3.4709 -6.4185 81.7822
COV434 CTRP2 -5.3247 -0.3488 -5.3544 73.0869
OVK18 CTRP2 -4.5486 4.2865 -5.0879 70.1015
IGROV-1 CTRP2 -3.7326 7.4452 -5.0386 59.4062
Caov-3 CTRP2 -1.7724 13.555 -5.2749 54.4075
SK-OV-3 CTRP2 -1.2838 22.6911 -8.9652 51.8511
COV644 CTRP2 -0.5911 8.6751 -2.054 45.8863
FU-OV-1 CTRP2 -0.4589 23.8448 -8.723 47.8202
JHOM-1 CTRP2 -0.3814 436.512 -214.5674 49.8643
COV362 CTRP2 -0.2497 15.8921 -4.7655 46.2104
ES2 CTRP2 -0.2395 4.7158 -0.5016 42.4523
OV7 CTRP2 -0.1928 11.9336 -2.9431 45.0181
DOV13 CTRP2 -0.1629 7.7308 -1.2552 43.2874
OAW42 CTRP2 0.0118 4.8012 -0.2462 40.8406
EFO-21 CTRP2 0.1693 7.6838 -0.8795 41.3772
OVCAR-5 CTRP2 0.3662 14.7793 -3.6394 43.739
ONCO-DG-1 CTRP2 0.7957 11.5389 -1.7515 40.397
OVTOKO CTRP2 0.9103 7.1958 0.0895 36.5395
HEY A8 CTRP2 1.0265 9.1957 -0.527 42.0523
OVSAHO CTRP2 1.0865 7.4308 0.2004 35.6247
SNU-840 CTRP2 1.5322 6.3277 1.0399 36.3896
TYK-nu CTRP2 1.9273 5.3224 1.7258 32.4514
OAW28 CTRP2 1.9627 6.7232 1.3877 29.1421
OV56 CTRP2 2.3821 8.8054 1.0608 28.8957
JHOC-5 CTRP2 2.5099 8.3786 1.3697 27.5072
JHOS-2 CTRP2 2.6124 6.6206 2.1271 24.5671
SNU-119 CTRP2 2.7885 3.853 2.7873 21.6952
RMG-I CTRP2 2.7937 4.4065 2.7764 25.0874
OVISE CTRP2 3.2993 9.51 1.7058 24.0907
EFO-27 CTRP2 3.4149 11.794 0.7647 26.8805
Kuramochi CTRP2 3.4728 10.3943 1.4774 24.414
OV-90 CTRP2 3.5771 12.008 0.8201 26.2822
OVCAR-4 CTRP2 4.2582 11.4192 1.7542 21.4328
⏷ Show the Full List of 38 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Aska-SS CTRP2 -3.135 5.2976 -3.7798 58.3317
Yamato-SS CTRP2 -0.4459 7.7176 -1.5572 44.8363
RD CTRP2 -9.943 7.7727 -11.904 72.8525
KYM-1 CTRP2 -6.5547 6.1308 -7.7291 68.5858
SW982 CTRP2 -6.2371 0.0608 -6.315 75.8495
HT-1080 CTRP2 -5.3916 3.7816 -5.899 68.0827
GCT CTRP2 -5.339 -1.3872 -5.3454 74.3615
Rh41 CTRP2 -4.4837 4.7725 -5.1246 64.0353
G-401 CTRP2 -4.3675 2.5961 -4.5963 65.696
TTC-709 CTRP2 -4.3338 3.244 -4.6583 64.9184
RKN CTRP2 -4.3137 9.5402 -6.3759 63.7549
BT-16 CTRP2 -4.214 3.3619 -4.5492 64.3231
SK-UT-1 CTRP2 -3.6843 2.9773 -3.9199 62.3539
TE 441.T CTRP2 -2.2535 8.2174 -3.6858 53.4655
A-204 CTRP2 -2.1435 3.991 -2.4261 53.9649
Tm87-16 CTRP2 -1.9057 7.1347 -2.9523 52.1399
BT-12 CTRP2 0.0944 4.6386 -0.1263 40.2233
Rh18 CTRP2 2.1734 5.9018 1.8579 26.8731
SK-LMS-1 CTRP2 3.3464 15.1733 -0.9258 31.4903
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 1.9231 5.0365 1.7764 27.9536
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MPP 89 CTRP2 -6.5601 6.2717 -7.774 68.4521
NCI-H28 CTRP2 -6.1796 -4.1249 -6.1796 81.1293
MSTO-211H CTRP2 -4.4636 11.0844 -7.1076 59.605
NCI-H2452 CTRP2 -1.1696 25.0274 -11.0319 47.4047
NCI-H2052 CTRP2 -0.8939 11.5912 -3.5284 47.8163
ACC-MESO-1 CTRP2 2.2232 5.8445 1.927 26.4758
JL-1 CTRP2 2.7005 4.2261 2.6894 22.3148
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC CTRP2 -6.1931 17.9252 -11.7293 60.236
22Rv1 CTRP2 -2.129 7.7907 -3.4068 53.0295
VCaP CTRP2 -0.7688 99.9283 -46.6896 49.6234
DU145 CTRP2 -0.442 16.1675 -5.0841 46.8868
PaCa-3 CTRP2 9.477 26.2562 -1.3631 20.75
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-15 CTRP2 -5.8129 1.8405 -6.037 71.8716
A-253 CTRP2 4.4737 19.2152 -1.8918 30.863
Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-16 CTRP2 -10.5549 -8.4903 -10.5549 98.9412
IM95 CTRP2 -9.6141 2.0246 -10.1384 79.4224
ECC10 CTRP2 -9.1549 9.7184 -11.6742 69.966
Fu97 CTRP2 -8.8995 4.4689 -9.8627 75.0178
NCC-StC-K140 CTRP2 -8.5292 5.9971 -9.8473 72.6014
GSS CTRP2 -6.1667 -5.0707 -6.1667 81.3401
SH-10-TC CTRP2 -6.1518 4.3087 -6.8351 69.6341
HGC-27 CTRP2 -5.6851 3.6712 -6.1953 69.1034
SNU-620 CTRP2 -5.5402 0.2611 -5.605 73.1464
23132/87 CTRP2 -5.3688 -3.6311 -5.3688 75.9807
SNU-5 CTRP2 -5.3532 -2.9528 -5.3533 75.6708
ECC12 CTRP2 -5.2332 1.2764 -5.3621 70.6377
HuG1-N CTRP2 -4.0938 3.2594 -4.4027 63.9211
NCI-N87 CTRP2 -3.7215 6.0543 -4.6162 60.2404
OCUM-1 CTRP2 -3.0445 9.8392 -5.1191 55.9358
SNU-216 CTRP2 -2.4964 7.4347 -3.6901 54.6853
MKN74 CTRP2 -1.4126 19.7063 -7.6857 49.8809
NUGC-4 CTRP2 -0.8201 6.814 -1.6706 46.6185
NUGC-3 CTRP2 -0.5032 12.0494 -3.3145 50.2036
Hs 746.T CTRP2 -0.4631 18.8073 -6.3306 47.3204
SNU-719 CTRP2 0.0425 7.4387 -0.9333 41.978
SNU-1 CTRP2 0.3398 12.9275 -2.8297 43.1402
KE-39 CTRP2 1.1072 11.523 -1.4245 38.8751
MKN1 CTRP2 1.3129 10.4486 -0.7464 36.9778
SNU-668 CTRP2 1.4577 8.3458 0.2649 34.1682
LMSU CTRP2 1.5348 6.2032 1.0787 31.5436
SNU-601 CTRP2 1.7756 12.6448 -1.2511 36.4815
KATO III CTRP2 3.3109 5.5977 3.1703 18.6952
AGS CTRP2 4.4 6.4842 4.113 11.983
MKN7 CTRP2 4.6373 6.6901 4.2943 10.6209
MKN45 CTRP2 6.8882 11.3108 4.077 6.7716
SNG-M CTRP2 -9.6316 7.6997 -11.5424 72.496
SNU-685 CTRP2 -4.4061 4.5867 -4.9981 63.9268
SNU-1077 CTRP2 0.9992 9.243 -0.5748 37.704
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
FTC-238 CTRP2 -9.0968 14.1233 -13.2206 66.7023
CAL-62 CTRP2 -6.7639 9.1152 -8.8784 66.2929
B-CPAP CTRP2 -4.3284 -0.699 -4.3346 68.4808
BHT-101 CTRP2 -1.1407 5.2913 -1.6048 48.1732
SW579 CTRP2 -1.0438 11.6008 -3.6892 48.4087
ML-1 [Human leukemia] CTRP2 -0.6366 97.496 -46.6097 48.9929
8305C CTRP2 -0.3252 9.3527 -2.025 44.7793
TT CTRP2 -0.3068 5.9312 -0.8563 43.3561
8505C CTRP2 0.2743 5.5018 -0.1132 39.4616
CGTH-W-1 CTRP2 3.8622 14.1137 0.0728 27.7294
TT2609-C02 CTRP2 4.0242 18.0663 -1.7233 31.5298
FTC-133 CTRP2 5.3229 19.786 -1.4365 28.1277
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PE/CA-PJ34 (clone C12) CTRP2 -10.7897 32.1012 -22.7383 61.5907
PE/CA-PJ49 CTRP2 -9.915 7.2409 -11.7135 73.3449
CAL-27 CTRP2 -8.9056 11.0716 -11.8753 68.5104
PE/CA-PJ15 CTRP2 -6.1915 10.2521 -8.6555 64.2282
YD-10B CTRP2 -6.0362 -4.8564 -6.0362 80.4674
Detroit 562 CTRP2 -3.1729 2.5445 -3.3194 60.1249
BICR 22 CTRP2 -2.604 8.6099 -4.2008 54.7581
SNU-1214 CTRP2 -2.5541 18.3808 -8.2133 52.7268
SCC-25 CTRP2 -1.8748 13.0795 -5.1781 51.3835
CAL-33 CTRP2 -1.8278 18.106 -7.3589 50.9575
SCC-9 CTRP2 -1.4549 13.8086 -5.0567 49.9808
BICR 18 CTRP2 -1.2687 12.6126 -4.3496 49.3186
BICR 6 CTRP2 -0.9206 5925.2628 -2959.3709 49.995
HSC-2 CTRP2 -0.5226 42.3338 -17.8268 48.8125
SCC-4 CTRP2 -0.2109 149.7421 -71.0816 49.5427
BICR 31 CTRP2 -0.172 11.8165 -2.8714 44.8939
HSC-4 CTRP2 0.3803 24.4781 -8.2335 48.1579
HSC-3 CTRP2 0.4976 9.3451 -1.1469 40.5437
YD-8 CTRP2 1.2795 7.9718 0.2149 34.9086
BHY CTRP2 1.4063 13.1119 -1.8346 38.5776
BICR 16 CTRP2 2.0322 16.8249 -2.9695 38.4178
SNU-1076 CTRP2 3.1062 19.0517 -3.0452 35.8942
SNU-899 CTRP2 3.1217 8.3822 2.0114 23.493
SNU-1066 CTRP2 4.4146 8.8015 3.1499 15.7109
FaDu CTRP2 4.4508 17.0498 -0.8369 28.6409
SNU-46 CTRP2 4.4796 12.2953 1.5352 21.6724
SNU-1041 CTRP2 6.0915 20.6729 -1.2307 26.1376
PE/CA-PJ41 (clone D2) CTRP2 9.0142 31.3584 -4.2308 27.112
BICR 56 CTRP2 12.6255 31.0542 -1.4928 16.8994
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SCaBER CTRP2 -9.5221 11.7615 -12.7881 68.8872
RT-112 CTRP2 -6.6993 10.5215 -9.2996 65.0907
JMSU-1 CTRP2 -5.8134 6.0977 -6.9109 66.8011
253J CTRP2 -4.7839 -1.9035 -4.7846 71.7896
CAL-29 CTRP2 -4.6822 14.1794 -8.5722 58.7415
639V CTRP2 -4.6362 4.3959 -5.2065 64.9269
VM-CUB-1 CTRP2 -3.8455 0.4163 -3.869 65.0755
SW1710 CTRP2 -3.5323 7.8633 -4.9548 58.4749
253J-BV CTRP2 -2.5753 4.8483 -3.065 55.9531
5637 CTRP2 -2.4647 7.2925 -3.6104 54.5948
UM-UC-3 CTRP2 -1.6456 13.7885 -5.2446 53.9621
U-BLC1 CTRP2 -1.3323 19.3992 -7.4633 49.6766
BFTC-905 CTRP2 -0.9584 7.7625 -2.1277 47.5329
TCCSUP CTRP2 -0.4234 5.1725 -0.7966 43.7953
T24 CTRP2 0.207 147.3589 -69.5344 49.3781
UM-UC-1 CTRP2 1.8068 19.1533 -4.3069 40.477
RT-4 CTRP2 2.3336 5.9354 2.0239 29.766
HT-1376 CTRP2 2.7161 10.6815 0.5881 33.1158
J82 CTRP2 2.7245 5.787 2.4882 22.9358
KMBC-2 CTRP2 3.5015 5.7458 3.3447 17.4832
HT-1197 CTRP2 3.6407 9.1369 2.2194 21.3041
KU-19-19 CTRP2 4.5955 13.4269 1.0856 22.918
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 -12.5309 10.7692 -15.6895 73.215

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5684).
2 Polo-like kinase (PLK) inhibitors in preclinical and early clinical development in oncology. Oncologist. 2009 Jun;14(6):559-70.
3 A specific inhibitor of polo-like kinase 1, GSK461364A, suppresses proliferation of Raji Burkitt's lymphoma cells through mediating cell cycle arrest, DNA damage, and apoptosis. Chem Biol Interact. 2020 Dec 1;332:109288. doi: 10.1016/j.cbi.2020.109288. Epub 2020 Oct 17.