Details of the Drug

General Information of Drug (ID: DM0PETL)

Drug Name
SB-525334
Synonyms
356559-20-1; SB 525334; SB-525334; SB525334; 6-(2-(tert-Butyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline; 6-[2-TERT-BUTYL-5-(6-METHYL-PYRIDIN-2-YL)-1H-IMIDAZOL-4-YL]-QUINOXALINE; CHEMBL401570; 6-[2-(1,1-DiMethylethyl)-5-(6-Methyl-2-pyridinyl)-1H-iMidazol-4-yl]quinoxaline; C21H21N5; 6-[2-tert-butyl-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl]quinoxaline; 6-(2-tert-butyl-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline; MLS006011134; SCHEMBL373474; QCR-68; SCHEMBL10000768; CTK4H5088; CHEBI:91391; AOB5969
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 343.4
Logarithm of the Partition Coefficient (xlogp) 3.7
Rotatable Bond Count (rotbonds) 3
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C21H21N5
IUPAC Name
6-[2-tert-butyl-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl]quinoxaline
Canonical SMILES
CC1=NC(=CC=C1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=NC=CN=C4C=C3
InChI
InChI=1S/C21H21N5/c1-13-6-5-7-16(24-13)19-18(25-20(26-19)21(2,3)4)14-8-9-15-17(12-14)23-11-10-22-15/h5-12H,1-4H3,(H,25,26)
InChIKey
DKPQHFZUICCZHF-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
9967941
ChEBI ID
CHEBI:91391
CAS Number
356559-20-1
TTD ID
D03ANS

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
TGF-beta receptor type I (TGFBR1) TTP4520 TGFR1_HUMAN Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
TGF-beta receptor type I (TGFBR1) DTT TGFBR1 2.62E-01 0.27 1.01
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 145 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JK1 CTRP2 3.3348 6.2722 3.0221 19.1531
MEC1 CTRP2 5.2975 6.6831 4.9964 6.0973
JM1 CTRP2 4.366 5.75 4.2839 11.4642
SK-MM-2 CTRP2 2.7397 4.2542 2.7283 22.0545
Daudi CTRP2 2.8536 4.1331 2.8488 21.2736
TALL-1 [Human adult T-ALL] CTRP2 3.0354 4.8086 2.9976 20.1738
SET-2 CTRP2 3.3962 5.2465 3.3266 17.879
A4/Fukuda CTRP2 3.4017 8.6781 2.1769 22.1082
MOLT-16 CTRP2 3.5753 4.6687 3.5683 16.4729
NCO2 CTRP2 3.763 4.9269 3.7489 15.2461
SU-DHL-8 CTRP2 3.8379 5.4243 3.7729 14.9214
MOLP-8 CTRP2 3.8615 5.9706 3.6819 15.1692
TF-1 CTRP2 3.8684 6.1772 3.6321 15.3282
MOLM-16 CTRP2 3.9297 5.9274 3.7674 14.6533
OCI-Ly3 CTRP2 3.9774 6.3979 3.6831 14.8163
Ri-1 CTRP2 4.0084 7.1738 3.4371 15.6531
KMS-26 CTRP2 4.0143 4.8418 4.0109 13.5363
MC116 CTRP2 4.0384 5.4602 3.9826 13.5538
SUP-B15 CTRP2 4.0996 5.5814 4.0281 13.2008
KMS-34 CTRP2 4.1163 5.6454 4.0342 13.1266
JVM-3 CTRP2 4.2447 6.6913 3.8722 13.3336
EJM CTRP2 4.2498 7.011 3.7575 13.755
BL-70 CTRP2 4.2847 5.0881 4.2789 11.7427
MHH-CALL-4 CTRP2 4.3001 5.881 4.1828 12.0273
KMS-12-BM CTRP2 4.311 5.4005 4.2818 11.6469
Kasumi-2 CTRP2 4.339 6.5784 4.0143 12.5288
697 CTRP2 4.3449 5.3155 4.3265 11.3841
KMS-28BM CTRP2 4.3614 6.6941 3.9967 12.5309
KE-97 CTRP2 4.3656 5.5054 4.3263 11.3176
RPMI-8226 CTRP2 4.3693 6.1287 4.1926 11.7807
GDM-1 CTRP2 4.3829 6.2663 4.166 11.8371
Ku812 CTRP2 4.391 5.7599 4.3089 11.2975
CMK CTRP2 4.4279 6.4686 4.1486 11.7696
Mino CTRP2 4.4348 5.2937 4.4223 10.7651
MM1.S CTRP2 4.464 5.7107 4.3979 10.7554
KHM-1B CTRP2 4.468 5.3212 4.4549 10.5463
DEL CTRP2 4.4856 5.0017 4.485 10.3871
THP-1 CTRP2 4.4893 5.4842 4.461 10.4558
SEM CTRP2 4.4924 5.4146 4.4721 10.4079
L-428 CTRP2 4.4968 7.4169 3.8522 12.7149
JURL-MK1 CTRP2 4.5352 7.7628 3.7421 13.0476
SU-DHL-1 CTRP2 4.5577 5.9473 4.4474 10.2881
EoL-1 CTRP2 4.5585 5.9911 4.4371 10.3225
KMS-27 CTRP2 4.5895 7.902 3.7356 12.9332
KMS-18 CTRP2 4.6074 6.0394 4.4775 10.0275
Ki-JK CTRP2 4.6153 19.4695 -1.8934 30.5611
KE-37 CTRP2 4.6214 5.2026 4.619 9.4882
HPB-ALL CTRP2 4.6714 7.2547 4.1027 11.2682
OCI-Ly19 CTRP2 4.6736 7.0318 4.198 10.8907
Peer CTRP2 4.6907 6.1327 4.542 9.5418
DB CTRP2 4.7152 7.7212 3.9442 11.7802
LAMA-84 CTRP2 4.737 6.0587 4.6137 9.1417
SKM-1 CTRP2 4.7448 6.5623 4.4573 9.6983
CML-T1 CTRP2 4.7473 5.7887 4.6896 8.8396
WSU-DLCL2 CTRP2 4.7612 5.5532 4.7413 8.6162
MOLT-13 CTRP2 4.7858 5.6196 4.7592 8.4751
P12-Ichikawa CTRP2 4.79 6.1619 4.6416 8.8805
AMO1 CTRP2 4.8031 6.2522 4.6278 8.8923
PF-382 CTRP2 4.8254 6.2786 4.6435 8.7687
SU-DHL-6 CTRP2 4.8488 11.0675 2.4781 17.327
EHEB CTRP2 4.8644 6.6194 4.5641 8.9552
KMS-21-BM CTRP2 4.882 6.02 4.7825 8.0914
Jurkat CTRP2 4.8895 6.1803 4.7444 8.2072
NB4 CTRP2 4.8996 5.8004 4.8522 7.7891
ALL-SIL CTRP2 4.9084 5.8807 4.8452 7.786
RPMI-6666 CTRP2 4.9341 6.3218 4.747 8.0664
KM-H2 CTRP2 4.9367 6.4719 4.6968 8.2471
RCH-ACV CTRP2 5.0066 6.536 4.7478 7.856
MOLP-2 CTRP2 5.0081 8.6812 3.787 11.6955
BV-173 CTRP2 5.0187 6.8894 4.6188 8.3207
Kasumi-1 CTRP2 5.0241 7.1365 4.5185 8.7005
SUP-HD1 CTRP2 5.0546 7.1237 4.5554 8.4749
P3HR-1 CTRP2 5.1897 8.1533 4.2141 9.5189
Pfeiffer CTRP2 5.195 6.5417 4.9464 6.5701
KMM-1 CTRP2 5.2131 8.0687 4.277 9.2061
SU-DHL-10 CTRP2 5.2271 6.2067 5.1033 5.8858
KMS-20 CTRP2 5.2281 8.5447 4.0625 10.0519
HT CTRP2 5.2412 6.0513 5.166 5.6143
HEL CTRP2 5.2539 6.169 5.1448 5.6535
KCL-22 CTRP2 5.2829 8.7008 4.0383 10.0262
NALM-6 CTRP2 5.302 6.5748 5.0462 5.8914
Hs 611.T CTRP2 5.3172 7.6275 4.5875 7.6889
L-363 CTRP2 5.3286 6.4747 5.1146 5.5543
L-540 CTRP2 5.3581 6.4181 5.1683 5.2661
CA46 CTRP2 5.3698 6.4454 5.1699 5.2275
PL21 CTRP2 5.3867 6.78 5.0469 5.6633
KO52 CTRP2 5.3977 6.5783 5.1451 5.248
M-07e CTRP2 5.3985 12.2824 2.3721 16.5179
NU-DUL-1 CTRP2 5.4172 6.0975 5.3447 4.434
HL-60 CTRP2 5.4189 5.9738 5.3797 4.303
MV4-11 CTRP2 5.4274 6.2146 5.3179 4.5032
LP-1 CTRP2 5.4533 7.2187 4.9133 6.0336
SUP-T1 CTRP2 5.4605 6.3482 5.3045 4.4594
NU-DHL-1 CTRP2 5.4666 6.2859 5.3346 4.3279
SU-DHL-4 CTRP2 5.4669 6.6445 5.1886 4.8933
JeKo-1 CTRP2 5.4742 7.6173 4.7438 6.6771
Karpas-422 CTRP2 5.4978 6.0977 5.4325 3.8718
Karpas-299 CTRP2 5.4993 6.8305 5.1387 5.0091
DND-41 CTRP2 5.521 6.7476 5.198 4.7163
EM-2 CTRP2 5.5273 7.1033 5.0401 5.3384
KYO-1 CTRP2 5.5359 7.1484 5.0271 5.3707
RPMI-8402 CTRP2 5.5418 6.9777 5.1132 5.0063
RS4;11 CTRP2 5.5468 7.1728 5.0261 5.3486
SIG-M5 CTRP2 5.565 5.9984 5.533 3.3045
HuT 78 CTRP2 5.5685 6.7861 5.2284 4.4744
HEL 92.1.7 CTRP2 5.5823 10.3555 3.4926 11.6349
OCI-AML-5 CTRP2 5.5919 6.1182 5.5286 3.2393
JJN-3 CTRP2 5.5986 7.0726 5.1239 4.8251
MOLM-6 CTRP2 5.599 6.7588 5.2714 4.225
ME1 CTRP2 5.6058 6.1483 5.5338 3.1791
RL CTRP2 5.6124 6.6296 5.3437 3.9013
P31/FUJ CTRP2 5.6231 6.6394 5.3501 3.8486
MOLT-3 CTRP2 5.6262 6.0632 5.5828 2.9384
HH [Human lymphoma] CTRP2 5.6465 7.7185 4.8563 5.819
MOLM-13 CTRP2 5.6624 6.663 5.3786 3.6351
KMS-11 CTRP2 5.6887 8.1256 4.6943 6.401
SUP-M2 CTRP2 5.6931 6.2209 5.6017 2.6736
NCI-H929 CTRP2 5.6967 8.6606 4.4363 7.4617
OPM-2 CTRP2 5.767 6.5543 5.5328 2.7535
Namalwa CTRP2 5.7797 6.6573 5.4967 2.8697
SUP-T11 CTRP2 5.7861 7.2532 5.2133 4.0263
Granta-519 CTRP2 5.7942 6.7616 5.4606 2.9836
OCI-AML-2 CTRP2 5.8191 6.4468 5.6344 2.2142
OCI-M1 CTRP2 5.8383 7.9528 4.9134 5.1675
A3/Kawakami CTRP2 5.8453 6.3874 5.6879 1.9328
Mono-Mac-1 CTRP2 5.8562 8.0795 4.8661 5.3284
K-562 CTRP2 5.8611 6.8038 5.5029 2.6565
MHH-CALL-3 CTRP2 5.8756 7.8494 4.9976 4.737
AML-193 CTRP2 5.9396 8.5062 4.7251 5.7511
F-36P CTRP2 5.9659 18.4399 -0.2189 23.8467
Ci-1 CTRP2 5.991 7.4947 5.2742 3.3419
Karpas-620 CTRP2 6.0041 6.8847 5.5902 1.9883
U-937 CTRP2 6.073 7.5236 5.3285 2.9543
Toledo CTRP2 6.1058 8.4296 4.9026 4.6823
SR CTRP2 6.1205 7.4687 5.3947 2.5876
REC-1 CTRP2 6.1425 7.5555 5.369 2.6552
U266B1 CTRP2 6.1627 15.8259 1.2519 18.9926
Mono-Mac-6 CTRP2 6.3388 9.9368 4.3378 6.6242
HDLM-2 CTRP2 6.4387 9.4167 4.6746 5.0402
OCI-Ly10 CTRP2 6.4636 8.5234 5.1345 3.0874
HD-MY-Z CTRP2 6.5627 9.0253 4.9608 3.6468
MJ CTRP2 6.6116 9.1556 4.9324 3.6866
MOTN-1 CTRP2 6.7376 8.9943 5.0996 2.816
Raji CTRP2 7.0926 11.4799 4.143 6.1777
Reh CTRP2 7.5811 12.8371 3.8277 6.7201
⏷ Show the Full List of 145 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE8 CTRP2 6.2776 19.2264 -0.3533 23.5955
TE15 CTRP2 6.4047 9.5716 4.5714 5.53
OE19 CTRP2 5.6286 13.3856 2.0218 17.3548
OE33 CTRP2 5.6696 10.3818 3.556 11.1909
KYSE-140 CTRP2 5.7764 9.8748 3.9015 9.5339
TE-6 CTRP2 5.8942 9.4746 3.4914 5.4187
KYSE-70 CTRP2 6.3101 9.5643 3.7322 3.7469
TE-10 CTRP2 6.3739 10.119 4.2748 6.8248
KYSE-150 CTRP2 6.5303 10.9797 3.9691 7.8232
TE-1 CTRP2 6.5935 8.5875 5.1963 2.6343
TE-4 CTRP2 6.6659 8.8788 5.1058 2.8949
KYSE-180 CTRP2 6.9894 11.9093 3.8574 7.5099
TE-14 CTRP2 7.2659 10.25 4.8516 3.0882
KYSE-410 CTRP2 7.5112 14.8104 2.8156 10.8348
COLO 680N CTRP2 7.6444 14.0897 3.2646 8.8663
TE-9 CTRP2 7.6643 13.758 3.44 8.1422
TE-11 CTRP2 8.5891 18.9889 1.5508 13.743
KYSE-520 CTRP2 8.6145 10.595 5.394 0.3372
KYSE-450 CTRP2 9.1392 16.525 3.104 7.4046
KYSE-510 CTRP2 9.5385 20.0358 1.7028 11.8499
KYSE-30 CTRP2 11.3388 22.1955 1.8385 9.1592
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 11.4455 35.3706 -4.3974 24.1452
PaTu 8988s CTRP2 3.3481 7.3407 2.6685 20.4236
Capan-1 CTRP2 3.3848 5.7176 3.2242 18.2739
SW1990 CTRP2 4.4172 7.5272 3.7225 13.435
HPAF-II CTRP2 4.5971 6.939 4.1548 11.2673
Panc 05.04 CTRP2 4.8423 7.9761 3.4069 7.8023
YAPC CTRP2 4.8938 7.058 3.9095 5.4313
QGP-1 CTRP2 4.9326 6.4427 4.7029 8.2357
KP-4 CTRP2 5.057 7.1985 4.5249 8.5893
SNU-213 CTRP2 5.3886 8.5884 4.1917 9.1527
SUIT-2 CTRP2 5.582 8.0378 4.6403 6.8597
Panc 03.27 CTRP2 5.5919 8.539 4.4025 7.8276
AsPC-1 CTRP2 5.6616 8.6993 4.3858 7.7471
L3.3 CTRP2 5.8045 9.3079 4.2087 8.191
KP-3 CTRP2 5.8267 9.3311 4.2162 8.1143
PK-59 CTRP2 5.8976 9.2498 4.3177 7.5455
PSN1 CTRP2 6.1073 8.81 4.7136 5.4736
HPAC CTRP2 6.3153 9.0154 4.7782 4.8219
TCC-Pan2 CTRP2 6.3544 11.8207 2.6762 8.2042
SU.86.86 CTRP2 6.4069 8.2814 5.2117 2.8596
MIA PaCa-2 CTRP2 6.4545 8.158 5.3068 2.3927
DAN-G CTRP2 6.5115 8.8638 5.0025 3.5563
Hs 766T CTRP2 6.6167 8.7005 5.1578 2.7562
BxPC-3 CTRP2 6.6915 10.1198 4.5176 5.2712
Panc 08.13 CTRP2 6.7244 11.2877 3.9656 7.5029
CFPAC-1 CTRP2 7.2559 10.8345 4.5682 4.2187
Capan-2 CTRP2 7.3163 11.7968 4.1468 5.8254
PK-45H CTRP2 7.3389 10.2606 4.8927 2.8388
PaTu 8988t CTRP2 7.4047 8.5942 5.6476 0.2811
HuP-T3 CTRP2 7.4835 10.6524 4.8007 3.0153
KP-2 CTRP2 7.5103 11.4094 4.4631 4.2914
SNU-410 CTRP2 7.5927 11.0275 4.6946 3.2889
Panc 10.05 CTRP2 7.6804 9.7227 5.3234 0.9831
HuP-T4 CTRP2 7.6961 16.0324 2.3511 12.3015
Panc 04.03 CTRP2 7.7159 13.6318 3.5372 7.6794
PaTu 8902 CTRP2 8.0973 9.2909 5.6617 0.0817
Panc 02.03 CTRP2 8.1271 9.6477 5.5478 0.222
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 51 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 10.4264 28.6676 -1.8558 20.5377
COLO 792 CTRP2 1.8047 3.9941 1.7768 28.3386
UACC-257 CTRP2 3.0715 5.5602 2.9182 20.3338
G-361 CTRP2 3.1943 5.538 2.8719 14.4425
SK-MEL-5 CTRP2 3.6737 5.9581 3.4803 16.4679
Malme-3M CTRP2 3.7816 8.1325 2.8045 18.7063
WM88 CTRP2 4.1002 6.4696 3.793 14.0486
SK-MEL-28 CTRP2 4.3101 6.4768 4.0181 12.5985
Mel JuSo CTRP2 4.5465 7.7687 3.7511 12.9828
WM115 CTRP2 4.5888 7.5146 3.9056 12.2615
Hs 944.T CTRP2 4.6351 8.1257 3.6805 13.0373
SK-MEL-1 CTRP2 4.9056 7.2104 4.3643 9.6197
HMCB CTRP2 4.96 7.9613 4.0803 10.6182
WM983B CTRP2 5.0224 9.8217 3.2486 13.8613
RVH-421 CTRP2 5.0682 8.6905 3.8401 11.3372
COLO 741 CTRP2 5.1076 8.9545 3.7502 11.6139
Mel Ho CTRP2 5.1483 11.6524 2.4626 16.7123
IPC-298 CTRP2 5.3331 8.6086 4.1301 9.5327
WM266-4 CTRP2 5.3813 8.6487 4.1554 9.3194
LOX-IMVI CTRP2 5.5821 9.4214 3.9567 9.7075
A-375 CTRP2 5.7971 7.6258 5.0392 4.728
HT-144 CTRP2 5.8573 9.0139 4.401 7.2773
WM1799 CTRP2 6.1589 10.2784 4.0221 8.2781
MDA-MB-435S CTRP2 6.2655 9.0796 4.7069 5.2093
IGR-1 CTRP2 6.2867 8.7557 4.8851 4.425
RPMI-7951 CTRP2 6.317 8.0231 5.272 2.757
MeWo CTRP2 6.3271 11.1607 3.7179 9.2331
SK-MEL-3 CTRP2 6.3348 12.2434 3.1835 11.4162
A2058 CTRP2 6.3552 7.6938 5.4622 1.9086
CJM [Human melanoma] CTRP2 6.4065 8.4497 5.1285 3.2048
Hs 294T CTRP2 6.4807 7.7523 5.5209 1.487
Hs 940.T CTRP2 6.4945 8.4245 5.2054 2.747
Hs 936.T CTRP2 6.498 10.3761 4.244 6.7346
WT2-iPS CTRP2 6.5057 11.5198 3.681 9.0614
COLO 800 CTRP2 6.5447 10.1232 4.4055 5.9809
K029AX CTRP2 6.5509 9.9311 4.5053 5.5548
A101D CTRP2 6.6522 8.0462 5.4933 1.3726
IGR-39 CTRP2 6.8731 11.7024 3.8729 7.6368
COLO 829 CTRP2 6.9445 13.8489 2.8645 11.5945
Hs 852.T CTRP2 7.0833 12.7941 3.4914 8.849
WM793 CTRP2 7.1028 11.3767 4.2006 5.927
SK-MEL-24 CTRP2 7.1594 14.0848 2.9114 11.0418
SK-MEL-31 CTRP2 7.1801 11.3262 4.2797 5.489
Hs 934.T CTRP2 7.1812 8.8877 5.421 1.0769
IGR-37 CTRP2 7.3612 11.7194 4.2152 5.4846
Hs 839.T CTRP2 7.3767 8.6892 5.5991 0.4062
UACC-62 CTRP2 7.467 12.2521 4.0313 6.0706
SK-MEL-30 CTRP2 7.5962 11.7641 4.3514 4.6172
Hs 895.T CTRP2 7.8517 9.2584 5.5819 0.2462
SK-MEL-2 CTRP2 8.9437 25.9094 -1.5875 22.0753
Hs 688(A).T CTRP2 13.0202 31.3057 -1.3532 16.1116
⏷ Show the Full List of 51 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 CTRP2 4.2658 7.841 3.431 14.9798
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NH-6 CTRP2 1.5432 3.9903 1.5047 30.1164
IMR-32 CTRP2 2.0651 3.0158 2.065 26.511
CHP-126 CTRP2 2.9919 6.6334 2.5355 21.9529
NB1 CTRP2 3.0604 5.0175 3 20.0846
SiMa CTRP2 3.5021 8.4248 2.3897 21.0408
KP-N-SI9s CTRP2 3.7905 6.2298 3.5316 15.9284
CHP-212 CTRP2 4.0231 6.204 3.793 14.277
Kelly CTRP2 4.3684 5.6108 4.3128 11.3554
SK-N-BE(2) CTRP2 4.4826 9.729 2.7804 17.0079
MHH-NB-11 CTRP2 5.0526 6.8066 4.6888 7.9564
SK-N-DZ CTRP2 5.2536 7.9517 4.3719 8.7218
SK-N-SH CTRP2 5.3974 10.173 3.4189 12.3322
KP-N-YN CTRP2 5.8398 13.023 2.3832 15.5549
SK-N-AS CTRP2 6.6291 8.5949 5.2175 2.4962
SK-N-FI CTRP2 6.6682 13.2407 2.952 11.7367
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-1079 CTRP2 3.7377 8.5923 2.5601 19.76
SNU-478 CTRP2 4.6655 8.0572 3.7423 12.7133
SNU-245 CTRP2 4.8451 7.3949 4.2215 10.3429
SNU-1196 CTRP2 5.8156 14.2857 1.7316 18.0257
SNU-308 CTRP2 5.9142 9.5899 4.162 8.1659
SNU-869 CTRP2 6.1368 8.465 4.9102 4.5921
HuH-28 CTRP2 6.3415 8.8039 4.9037 4.251
HuCC-T1 CTRP2 6.7533 8.3921 5.3956 1.6241
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-MC CTRP2 2.6355 2.963 2.6355 22.7108
CADO-ES1 CTRP2 3.3277 4.325 3.3255 18.1063
SK-ES-1 CTRP2 3.3512 5.5919 3.2153 18.41
A-673 CTRP2 3.5442 5.4314 3.4555 16.9599
MHH-ES-1 CTRP2 3.8448 7.0422 3.313 16.5851
SaOS-2 CTRP2 4.6822 9.0078 3.3164 14.3857
HOS CTRP2 4.7824 6.2612 4.6024 9.047
U2OS CTRP2 4.996 8.6729 3.7793 11.7557
MG-63 CTRP2 6.4532 7.8168 5.4714 1.7245
TC71 CTRP2 6.4595 10.9015 3.9525 8.0171
SJSA-1 CTRP2 6.5004 11.2467 3.8128 8.525
SW1353 CTRP2 6.518 12.4177 3.2433 10.8352
Hs 888.T CTRP2 6.5868 8.5474 5.211 2.5842
Hs 822.T CTRP2 6.7035 7.8583 5.61 0.879
G-292 clone A141B1 CTRP2 6.7185 9.4504 4.8652 3.7968
CAL-78 CTRP2 6.7797 11.3139 3.9946 7.2902
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 67 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC2218 CTRP2 2.2643 6.3948 1.8183 26.725
ZR-75-30 CTRP2 2.5011 4.3485 2.4766 23.688
MCF-7 CTRP2 2.6652 6.8181 2.1196 24.4343
MDA-MB-361 CTRP2 2.7802 4.6288 2.7462 21.861
MDA-MB-157 CTRP2 2.8372 5.4617 2.6844 21.8914
MDA-MB-453 CTRP2 3.1817 5.4439 3.0613 19.4846
HCC1500 CTRP2 3.3034 6.4843 2.9224 19.6112
MDA-MB-468 CTRP2 3.477 5.2049 3.4192 17.3004
BT-20 CTRP2 4.0056 5.9473 3.8451 14.1415
DU4475 CTRP2 4.2772 6.1861 4.0753 12.4849
Hs 578Bst CTRP2 4.4636 14.5206 0.4262 25.2745
CAL-148 CTRP2 4.4775 5.2203 4.471 10.4608
HCC1419 CTRP2 4.5586 6.9352 4.1154 11.5251
ZR-75-1 CTRP2 4.893 7.3413 3.7675 6.0712
CAL-51 CTRP2 5.1019 7.0525 4.6352 8.0356
HCC1428 CTRP2 5.1792 8.1699 4.196 9.6178
BT-474 CTRP2 5.3403 6.5111 5.1125 5.53
AU565 CTRP2 5.4077 7.9751 4.508 7.8021
SK-BR-3 CTRP2 5.5866 6.9781 5.157 4.719
CAL-85-1 CTRP2 5.7466 8.2625 4.6783 6.3441
CAMA-1 CTRP2 5.7489 8.0825 4.7697 5.9569
HCC1954 CTRP2 5.821 7.4523 5.1466 4.2283
MDA-MB-231 CTRP2 5.8339 9.0389 4.3683 7.4618
T-47D CTRP2 5.9344 11.1974 3.3757 11.3999
HCC202 CTRP2 5.9602 9.0078 4.492 6.6894
HMC-1-8 CTRP2 6.3602 8.5553 5.0414 3.6445
Hs 578T CTRP2 6.6448 11.6675 3.7162 8.6707
HCC38 CTRP2 6.7036 8.4907 5.3173 1.9934
HCC1395 CTRP2 6.7501 11.7514 3.7556 8.3266
HCC1143 CTRP2 7.0483 12.1576 3.7787 7.7365
HCC1937 CTRP2 7.2115 11.9291 4.0088 6.5416
HCC1806 CTRP2 7.332 9.3641 5.295 1.3675
HDQ-P1 CTRP2 7.3881 8.9732 5.4904 0.6937
JIMT-1 CTRP2 7.3989 11.0916 4.5407 4.1337
CAL-120 CTRP2 7.659 8.8906 5.6404 0.2038
KPL-1 CTRP2 12.7127 36.5207 -4.0578 22.0321
BT 239 CTRP2 3.1373 4.2178 3.1346 19.3765
BT 330 CTRP2 4.556 5.8231 4.4748 10.1959
BT 231 CTRP2 4.6265 7.2156 4.0724 11.507
BT 504 CTRP2 4.7236 6.2064 4.5557 9.3933
BT 228 CTRP2 5.2633 7.2357 4.717 7.2961
BT 248 CTRP2 5.5766 9.3755 3.9745 9.645
BT 416 CTRP2 5.585 15.5261 0.9155 21.2764
BT 428 CTRP2 5.983 10.0301 4.0002 8.7083
BT 145 CTRP2 5.99 8.8391 4.6015 6.1708
BT 286 CTRP2 6.0406 8.8609 4.633 5.94
BT 340 CTRP2 6.0506 11.9174 3.113 12.2455
BT 359 CTRP2 6.3888 9.9339 4.3787 6.3635
BT 422 CTRP2 6.4188 7.6657 5.5206 1.5752
BT 245 CTRP2 6.4656 8.3812 5.2057 2.7906
BT147 CTRP2 6.558 9.0083 4.9656 3.6344
BT 498 CTRP2 6.5583 11.8168 3.5745 9.4071
BT 172 CTRP2 6.7508 10.5405 4.3544 5.8497
BT 139 CTRP2 6.872 9.0638 5.1562 2.4057
BT 131 CTRP2 6.9064 9.0796 5.171 2.3026
BT 179 CTRP2 6.9212 9.1043 5.1689 2.292
BT 328 CTRP2 6.9602 8.6215 5.4153 1.3132
BT 224 CTRP2 6.9873 8.3871 5.5341 0.8705
BT 444 CTRP2 7.0943 9.1499 5.2548 1.7565
BT 440 CTRP2 7.1598 9.71 5.0367 2.5047
BT 482 CTRP2 7.2373 8.6162 5.5642 0.5822
BT 232 CTRP2 7.3688 13.2786 3.4629 8.505
BT 159 CTRP2 7.4456 10.6391 4.7833 3.128
BT 320 CTRP2 7.5564 11.0315 4.6701 3.4271
BT 216 CTRP2 7.784 9.7219 5.3738 0.7653
BT 187 CTRP2 7.9276 16.4581 2.3114 12.0771
BT 333 CTRP2 10.7546 22.9289 1.1308 12.099
⏷ Show the Full List of 67 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 6.5275 7.966 5.4503 1.7042
Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
T98G CTRP2 3.2514 6.1242 2.9742 19.5789
D283 Med CTRP2 3.9641 9.6625 2.3039 20.1419
SNU-466 CTRP2 4.0443 9.0985 2.6438 18.6358
ONS-76 CTRP2 4.2305 5.3381 4.2036 12.1751
U-251MG CTRP2 4.2699 5.4091 4.2371 11.9331
Daoy CTRP2 4.8061 5.8264 4.7456 8.4577
GOS-3 CTRP2 5.1189 9.3871 3.5505 12.4079
GB-1 CTRP2 5.2704 10.6842 3.0517 14.107
U-87MG ATCC CTRP2 5.8141 9.0186 4.3612 7.5321
8-MG-BA CTRP2 5.9603 8.9969 4.4975 6.6662
LN-18 CTRP2 6.2169 7.4133 5.4979 1.985
SW1783 CTRP2 6.331 11.4317 3.5857 9.7735
SF295 CTRP2 6.3859 10.5258 4.0815 7.6113
U-118MG CTRP2 6.4717 9.464 4.6763 4.9766
GMS-10 CTRP2 6.5086 8.9613 4.9524 3.7681
Hs 683 CTRP2 6.59 10.1242 4.4394 5.7631
SNU-489 CTRP2 6.6189 8.83 5.0965 3.003
LN-229 CTRP2 6.6414 8.518 5.2628 2.2959
YKG-1 CTRP2 6.6897 7.9067 5.5802 1.0019
KALS-1 CTRP2 6.8585 12.4136 3.5102 9.1483
SF268 CTRP2 6.9048 11.7064 3.8946 7.4954
YH-13 CTRP2 7.1115 11.0868 4.3476 5.3155
CCF-STTG1 CTRP2 7.1155 8.6256 5.4993 0.8744
KNS-81 CTRP2 7.1423 8.4741 5.5766 0.6114
DK-MG CTRP2 7.1515 10.1008 4.848 3.2504
KNS-60 CTRP2 7.4194 8.7619 5.5895 0.4078
KNS-42 CTRP2 7.4278 10.396 4.8849 2.7615
NMC-G1 CTRP2 7.4361 8.8318 5.5696 0.4484
GaMG CTRP2 7.5208 11.1826 4.5769 3.8326
SNU-626 CTRP2 7.5895 9.0051 5.5692 0.3733
SNU-1105 CTRP2 7.6456 12.7469 3.9154 6.2774
SNU-738 CTRP2 7.7029 8.8839 5.6597 0.16
M059K CTRP2 7.7706 11.7621 4.4642 3.9548
KG-1-C CTRP2 7.9356 9.1189 5.6631 0.1055
A-172 CTRP2 7.9647 12.6903 4.153 4.9124
SW1088 CTRP2 8.3432 15.27 3.1782 8.1801
SNU-201 CTRP2 8.9265 19.9052 1.3443 13.9243
SF126 CTRP2 8.9295 17.5443 2.4848 9.9537
SF539 CTRP2 9.0253 15.7753 3.382 6.5179
42-MG-BA CTRP2 9.0957 19.572 1.6237 12.7417
Becker CTRP2 9.1115 16.6504 3.0276 7.7212
DBTRG-05MG CTRP2 9.4126 17.9546 2.6079 8.8624
TM-31 CTRP2 10.7622 21.4851 1.8121 9.9136
CAS-1 CTRP2 10.8385 36.074 -5.1865 26.1682
SNB-75 CTRP2 10.8454 22.9706 1.1698 11.8637
⏷ Show the Full List of 45 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HEC-50B CTRP2 2.6875 3.7782 2.6863 22.3681
JHUEM-1 CTRP2 3.7856 6.1775 3.5417 15.906
AN3-CA CTRP2 3.795 5.8936 3.629 15.5627
HEC-1-A CTRP2 3.8352 6.0505 3.6317 15.4298
KLE CTRP2 4.2162 6.3399 3.9614 13.0842
HEC-59 CTRP2 4.6567 5.9944 4.5433 9.6401
HEC-265 CTRP2 4.8661 13.6248 1.2324 21.8079
JHUEM-2 CTRP2 4.9538 6.5771 4.6758 8.2784
HEC-151 CTRP2 5.2737 6.4408 5.0695 5.8797
HEC-1-B CTRP2 5.4072 6.2624 5.2793 4.706
HEC-251 CTRP2 5.4916 8.2848 4.4357 7.9102
HEC-108 CTRP2 5.5384 8.1582 4.541 7.3688
ESS-1 CTRP2 5.7721 9.2625 4.2032 8.2805
MFE-296 CTRP2 6.1358 10.2606 4.012 8.3643
MFE-319 CTRP2 6.2622 7.9844 5.2494 2.9443
HEC-6 CTRP2 6.2653 9.6943 4.4001 6.496
RL95-2 CTRP2 6.5122 7.7631 5.5366 1.3823
EFE-184 CTRP2 6.7432 9.5966 4.8116 3.9785
EN CTRP2 7.5438 11.984 4.2121 5.2395
Ishikawa (Heraklio) 02 ER- CTRP2 4.2908 5.6401 4.2239 11.9117
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-1272 CTRP2 3.5067 5.2492 3.4446 17.1175
TUHR14TKB CTRP2 3.7703 10.1714 1.8756 40.7261
UO-31 CTRP2 4.8635 8.3654 3.7964 12.0044
Caki-1 CTRP2 5.0387 7.7738 4.2452 9.7573
769-P CTRP2 5.7522 7.0905 5.2616 3.9014
Caki-2 CTRP2 6.1773 10.9029 2.9972 7.1105
A-498 CTRP2 6.2081 7.3495 5.5227 1.8965
CAL-54 CTRP2 6.2409 9.4969 4.4791 6.2096
VMRC-RCZ CTRP2 6.3876 10.1903 4.2501 6.9036
KMRC-1 CTRP2 6.7216 9.571 4.8087 4.0238
BFTC-909 CTRP2 6.7817 8.3299 5.442 1.4131
KMRC-3 CTRP2 7.0236 11.8998 3.8873 7.3321
TUHR10TKB CTRP2 7.1511 23.7536 -1.9057 25.7046
RCC10RGB CTRP2 7.154 9.5128 5.1246 2.1765
OS-RC-2 CTRP2 7.2463 11.8477 4.0731 6.2277
ACHN CTRP2 7.3628 9.4406 5.2783 1.396
VMRC-RCW CTRP2 7.4765 9.5094 5.3096 1.1886
786-O CTRP2 7.7383 13.1401 3.7897 6.6454
TUHR4TKB CTRP2 8.0683 9.338 5.6352 0.1143
KMRC-2 CTRP2 9.4193 17.7066 2.7287 8.419
KMRC-20 CTRP2 10.2861 19.1785 2.5854 7.8732
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-CO-1 CTRP2 2.4887 6.3887 2.0647 25.1665
SNU-61 CTRP2 3.3484 6.0608 3.0977 18.8383
C2BBe1 CTRP2 3.5821 7.4951 2.8578 19.0502
LS123 CTRP2 3.674 4.7906 3.6646 15.8233
COLO 320 CTRP2 3.8599 6.8742 3.3915 16.2455
SW620 CTRP2 4.0963 5.8902 3.9584 13.4574
SNU-C1 CTRP2 4.5686 6.9691 4.1126 11.5084
SNU-407 CTRP2 4.6894 6.9451 4.2499 10.6469
SW948 CTRP2 4.8839 7.8626 4.0501 10.929
LS180 CTRP2 4.905 6.8473 4.5169 9.0242
HT-55 CTRP2 4.9317 6.4712 4.6916 8.2811
T84 CTRP2 5.0462 11.1822 2.6026 16.3938
CCK-81 CTRP2 5.0665 7.8396 4.2422 9.7012
LoVo CTRP2 5.149 9.5364 3.5057 12.5239
LS513 CTRP2 5.1517 6.3344 4.978 6.5725
COLO201 CTRP2 5.393 7.5951 4.6764 7.1446
SW1417 CTRP2 5.3976 7.6167 4.6706 7.1576
SNU-C5 CTRP2 5.4677 8.1145 4.4967 7.7115
CW-2 CTRP2 5.4719 6.8014 5.1242 5.1366
SNU-1033 CTRP2 5.5107 8.3734 4.4099 7.9749
LS1034 CTRP2 5.6701 7.0242 5.216 4.2789
COLO205 CTRP2 5.7392 7.6462 4.9768 5.1136
NCI-H508 CTRP2 5.763 7.1699 5.2328 3.9966
KM12 CTRP2 5.8788 9.0409 4.406 7.2128
CL-11 CTRP2 5.9161 7.5208 5.1967 3.8189
DLD-1 CTRP2 5.9293 6.9046 5.515 2.458
SW48 CTRP2 5.939 9.724 4.116 8.3094
HCT 15 CTRP2 5.955 8.1626 4.9099 4.9438
HT115 CTRP2 5.9938 8.5186 4.7649 5.4768
RCM-1 [Human ESC] CTRP2 6.0197 7.8716 5.1102 3.9747
HCT 116 CTRP2 6.1296 7.587 5.3429 2.7882
SW1116 CTRP2 6.2417 7.888 5.2814 3.2882
NCI-H747 CTRP2 6.2855 8.867 4.8287 4.6633
RKO CTRP2 6.2902 9.6185 4.4579 6.2088
SNU-C4 CTRP2 6.3751 8.3283 5.165 3.1052
SNU-C2A CTRP2 6.4658 10.9856 3.9156 8.1599
NCI-H716 CTRP2 6.4934 7.9373 5.4409 1.7896
MDST8 CTRP2 6.5228 8.6082 5.136 2.9881
COLO 678 CTRP2 6.6252 9.4785 4.7841 4.2762
LS411N CTRP2 6.6367 8.6569 5.1927 2.5852
OUMS-23 CTRP2 6.6848 8.1781 5.4523 1.4901
HCT 8 CTRP2 7.1769 9.7096 5.0476 2.442
HT-29 CTRP2 7.8826 9.2526 5.5961 0.2123
HCC-56 CTRP2 7.907 8.8551 5.7425 0.0381
SNU-503 CTRP2 8.7708 10.3057 5.5532 0.093
⏷ Show the Full List of 45 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-398 CTRP2 2.9197 5.0315 2.848 21.0604
SNU-886 CTRP2 2.966 6.6682 2.496 22.1738
JHH-2 CTRP2 3.2819 6.1394 3.0031 19.3819
PLC/PRF/5 CTRP2 3.6994 5.8299 3.5404 16.174
JHH-5 CTRP2 3.7574 6.1526 3.5181 16.0771
JHH-4 CTRP2 3.9706 6.1334 3.7562 14.5689
Li-7 CTRP2 4.9883 8.75 3.735 11.9549
Hep-G2 CTRP2 5.3527 8.8042 3.4149 6.724
SNU-878 CTRP2 5.3592 7.6395 4.6226 7.4452
HuH-6 CTRP2 5.6864 8.1693 4.6706 6.5047
SNU-182 CTRP2 5.8263 10.4906 3.637 10.5346
JHH-1 CTRP2 5.9263 9.9372 3.9987 8.8262
SNU-761 CTRP2 5.9502 8.6481 3.9301 3.4253
Hep 3B2.1-7 CTRP2 6.3437 9.2874 4.6651 5.2451
HLF CTRP2 6.468 7.9645 5.4103 1.9501
HuH-1 CTRP2 6.5635 7.8482 5.5297 1.3425
SNU-423 CTRP2 6.7772 10.3097 4.4874 5.2581
JHH-6 CTRP2 6.9148 7.7921 5.7457 0.2849
SK-HEP-1 CTRP2 7.1951 10.3447 4.761 3.5356
SNU-449 CTRP2 7.2931 9.4922 5.2164 1.6833
SNU-475 CTRP2 7.4993 10.2524 4.9936 2.274
SNU-387 CTRP2 8.0498 10.4123 5.2189 1.0316
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 134 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1385 CTRP2 -0.0841 8.4289 -1.4187 43.1712
COLO 699 CTRP2 0.6368 1.5979 0.6368 36.0261
NCI-H2106 CTRP2 0.959 2.6184 0.9572 33.8855
NCI-H524 CTRP2 1.605 4.46 1.5224 29.853
NCI-H146 CTRP2 2.3319 4.0176 2.3198 24.7736
RERF-LC-MS CTRP2 2.4034 3.6754 2.4013 24.2639
NCI-H1155 CTRP2 2.528 5.5129 2.3379 24.0802
NCI-H1568 CTRP2 3.0137 7.1701 2.3732 22.4818
NCI-H1755 CTRP2 3.0486 6.1436 2.7474 21.0134
NCI-H209 CTRP2 3.2487 6.3852 2.8939 19.8786
DMS 114 CTRP2 3.4736 6.325 3.1575 18.2435
NCI-H1341 CTRP2 3.6876 5.6576 3.5667 16.1176
NCI-H1092 CTRP2 3.6986 7.299 3.0586 17.9619
NCI-H2141 CTRP2 3.7014 8.051 2.7557 19.1105
NCI-H1694 CTRP2 3.7253 5.4451 3.6483 15.7131
NCI-H1105 CTRP2 3.7757 7.0629 3.2313 17.0899
Lu-65 CTRP2 3.7844 6.8666 3.3131 16.7563
NCI-H1703 CTRP2 3.7915 6.6629 3.3928 16.4375
NCI-H1581 CTRP2 3.8694 5.9401 3.6985 15.0852
NCI-H1184 CTRP2 4.0373 6.2831 3.7845 14.2656
NCI-H1573 CTRP2 4.0923 9.3294 2.5855 18.7388
COR-L95 CTRP2 4.1274 6.9247 3.6599 14.4707
COR-L105 CTRP2 4.3357 7.2513 3.7526 13.5374
DMS 454 CTRP2 4.3815 6.8349 3.9658 12.5913
NCI-H211 CTRP2 4.423 6.9205 3.9772 12.4316
NCI-H2405 CTRP2 4.4922 7.7075 3.7222 13.2385
SHP-77 CTRP2 4.5014 7.3189 3.8984 12.5222
NCI-H2085 CTRP2 4.5497 6.7702 4.1702 11.3401
NCI-H1915 CTRP2 4.5846 11.7385 1.905 20.1029
Calu-6 CTRP2 4.6388 6.8511 4.2338 10.8484
Calu-3 CTRP2 4.6391 7.3215 4.0407 11.5973
NCI-H23 CTRP2 4.6766 9.0367 3.2973 14.4762
HCC4006 CTRP2 4.7046 7.5925 3.9905 11.6237
COR-L47 CTRP2 4.7096 7.5473 4.0156 11.5111
NCI-H1650 CTRP2 4.8397 9.6302 3.1698 14.6026
EBC-1 CTRP2 4.9125 7.8797 4.0709 10.774
NCI-H1975 CTRP2 4.9546 7.5017 4.2854 9.807
NCI-H522 CTRP2 4.9587 7.0523 4.4874 8.9951
HCC2108 CTRP2 4.9593 8.3651 3.8903 11.391
VMRC-LCD CTRP2 5.0316 6.4489 4.8072 7.5594
NCI-H69 CTRP2 5.0407 9.6349 3.3567 13.3791
HCC1588 CTRP2 5.0486 6.935 4.6307 8.1938
NCI-H446 CTRP2 5.0521 12.3628 2.0244 18.59
NCI-H358 CTRP2 5.0568 9.8703 3.2568 13.7499
NCI-H1395 CTRP2 5.0588 8.2603 4.0366 10.5556
NCI-H1944 CTRP2 5.102 9.1041 3.6724 11.9463
NCI-H1435 CTRP2 5.1271 9.0816 3.707 11.7468
LXF 289 CTRP2 5.1611 9.19 3.686 11.7556
SBC-5 CTRP2 5.2054 6.1102 5.11 5.9254
HCC1833 CTRP2 5.2134 9.8586 3.4071 12.7841
KNS-62 CTRP2 5.2876 6.6647 4.9938 6.1343
EPLC-272H CTRP2 5.342 8.2092 4.3326 8.6764
NCI-H727 CTRP2 5.3593 8.5768 4.1701 9.308
NCI-H2081 CTRP2 5.4275 8.6125 4.2159 8.9651
PC-14 CTRP2 5.4601 10.0726 3.5248 11.761
HCC1195 CTRP2 5.4759 7.6147 4.7466 6.6615
HOP-62 CTRP2 5.5313 8.7695 4.2337 8.6625
NCI-H650 CTRP2 5.5326 7.9063 4.6588 6.8937
DMS 53 CTRP2 5.5674 8.2808 4.5075 7.4438
NCI-H2342 CTRP2 5.643 8.4559 4.4897 7.3533
NCI-H2122 CTRP2 5.6526 8.8376 4.3092 8.0864
MOR/CPR CTRP2 5.6592 7.0299 5.2028 4.3588
LUDLU-1 CTRP2 5.6794 8.5588 4.4714 7.3519
SK-LU-1 CTRP2 5.7063 7.1333 5.1976 4.2705
NCI-H2444 CTRP2 5.7079 9.5612 3.3123 6.5282
DMS 273 CTRP2 5.7341 8.0913 4.7522 6.0618
NCI-H226 CTRP2 5.7951 6.9526 5.3689 3.3603
A-549 CTRP2 5.8127 10.3064 3.7174 10.2278
NCI-H1666 CTRP2 5.8225 8.0905 4.831 5.5455
NCI-H1734 CTRP2 5.8232 8.2761 4.7393 5.9282
NCI-H661 CTRP2 5.8238 9.1007 4.3287 7.6487
NCI-H1339 CTRP2 5.8645 9.9053 3.962 9.1027
NCI-H460 CTRP2 5.87 8.8599 4.4888 6.8833
EKVX CTRP2 5.8817 11.5212 3.1693 12.3503
NCI-H526 CTRP2 5.8846 9.2042 4.3295 7.5223
NCI-H2023 CTRP2 5.898 10.773 2.8566 8.2025
NCI-H841 CTRP2 5.9045 11.1948 3.3517 11.5581
NCI-H292 CTRP2 6.0339 7.4507 5.3325 3.0126
NCI-H520 CTRP2 6.0398 9.2717 4.4269 6.8076
NCI-H2228 CTRP2 6.0874 9.1143 4.5451 6.2194
SK-MES-1 CTRP2 6.1007 10.8297 3.6985 9.7394
Sq-1 CTRP2 6.1014 7.9258 5.1508 3.6476
NCI-H1355 CTRP2 6.117 10.7377 3.758 9.4605
COR-L51 CTRP2 6.1211 7.6255 5.3168 2.9135
NCI-H2087 CTRP2 6.1461 9.2884 4.5063 6.2712
NCI-H1869 CTRP2 6.1599 10.2749 4.0246 8.2656
NCI-H2172 CTRP2 6.1781 11.0322 3.661 9.7478
NCI-H889 CTRP2 6.2227 8.5918 4.9161 4.4097
LK2 CTRP2 6.2532 8.7962 4.8384 4.6804
NCI-H2196 CTRP2 6.2829 8.7128 4.9034 4.355
NCI-H2170 CTRP2 6.3182 9.4933 4.5425 5.8039
LC-1/sq-SF CTRP2 6.3803 7.4961 5.5758 1.4079
NCI-H647 CTRP2 6.4866 10.451 4.1979 6.9469
NCI-H441 CTRP2 6.5662 8.6854 5.1295 2.9479
SW1271 CTRP2 6.5918 10.2789 4.3643 6.0725
NCI-H2126 CTRP2 6.7034 10.2851 4.4451 5.5519
NCI-H322 CTRP2 6.7254 9.3732 4.9077 3.6127
HCC827 CTRP2 6.7268 8.6773 5.244 2.2527
NCI-H1563 CTRP2 6.7632 11.8076 3.7377 8.3779
BEN CTRP2 6.765 7.8124 5.6641 0.6329
LCLC-97TM1 CTRP2 6.8079 14.0866 2.6405 12.7125
NCI-H1693 CTRP2 6.8224 9.6654 4.8341 3.7674
HARA [Human squamous cell lung carcinoma] CTRP2 6.8596 9.6008 4.8912 3.4816
NCI-H1299 CTRP2 6.8635 10.959 4.2318 6.1738
LCLC-103H CTRP2 6.9596 8.2417 5.5821 0.7358
HCC15 CTRP2 6.9611 11.0168 4.2746 5.8432
HCC2935 CTRP2 7.138 11.1775 4.3223 5.3786
NCI-H1373 CTRP2 7.1446 11.1589 4.3359 5.3138
NCI-H838 CTRP2 7.1811 11.5053 4.1935 5.8373
NCI-H1792 CTRP2 7.2016 12.1725 3.883 7.0682
RERF-LC-A1 CTRP2 7.2021 12.2935 3.8243 7.3063
NCI-H1838 CTRP2 7.2201 10.6965 4.6102 4.1009
RERF-LC-Ad1 CTRP2 7.2734 8.1393 5.7626 0.1136
T3M-10 CTRP2 7.2894 9.3497 5.2777 1.4689
HCC366 CTRP2 7.3246 12.8896 3.6212 7.9376
HCC95 CTRP2 7.4241 12.1094 4.0705 5.9752
NCI-H196 CTRP2 7.4457 11.7833 4.2421 5.2566
NCI-H1793 CTRP2 7.6172 10.8665 4.7839 2.9216
NCI-H2286 CTRP2 7.7269 19.1994 0.811 17.5627
HCC1171 CTRP2 7.774 19.5521 0.6723 17.916
NCI-H2110 CTRP2 7.8519 10.0854 5.2574 1.0572
NCI-H2291 CTRP2 7.8936 10.1301 5.2593 1.0214
HCC44 CTRP2 7.9855 18.2168 1.4904 14.9025
NCI-H2030 CTRP2 8.0622 16.1641 2.5517 10.9728
Calu-1 CTRP2 8.1057 16.4587 2.4391 11.3261
HCC78 CTRP2 8.1912 14.5393 3.4254 7.4386
LOU-NH91 CTRP2 8.233 9.861 5.5118 0.2508
NCI-H2009 CTRP2 8.562 19.3266 1.3666 14.4038
Lu-99 CTRP2 8.5649 10.0687 5.5615 0.1133
CAL-12T CTRP2 8.9048 19.5914 1.4813 13.5011
HCC2279 CTRP2 9.6251 21.363 1.1248 13.624
HCC1438 CTRP2 9.7417 17.6575 2.9535 7.2177
HOP-92 CTRP2 12.7617 31.2842 -1.5122 16.7844
Hs 888.Lu CTRP2 4.9877 7.4361 4.3484 9.4708
⏷ Show the Full List of 134 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Yamato-SS CTRP2 4.0315 6.4096 3.7381 14.4534
Aska-SS CTRP2 5.512 8.4052 4.3955 8.0319
HT-1080 CTRP2 2.9909 4.4848 2.9758 20.3935
Rh41 CTRP2 3.0133 5.0788 2.9413 20.438
A-204 CTRP2 3.2572 5.1344 3.1941 18.7828
G-401 CTRP2 3.7208 6.4501 3.3872 16.6656
G-402 CTRP2 3.8468 8.6194 2.6598 19.0888
TE 617.T CTRP2 3.8644 5.8428 3.7172 15.0338
KYM-1 CTRP2 4.0314 5.1397 4.0131 13.4721
MES-SA CTRP2 4.5872 6.6166 4.268 10.8628
RKN CTRP2 4.772 6.8703 4.3674 9.9664
TE 441.T CTRP2 4.977 7.1674 4.4565 9.0687
SW982 CTRP2 6.1406 8.5563 4.8677 4.7634
RD CTRP2 6.158 7.4749 5.4215 2.407
Rh18 CTRP2 6.4156 7.7163 5.4939 1.6878
SK-UT-1 CTRP2 6.4839 8.1193 5.3465 2.186
Hs 729.T CTRP2 6.554 10.7504 4.1014 7.2311
TTC-709 CTRP2 6.7423 8.6962 5.2453 2.2264
GCT CTRP2 6.8013 12.2799 3.5327 9.154
Tm87-16 CTRP2 6.8344 8.6283 5.3364 1.752
SK-LMS-1 CTRP2 6.8415 10.9154 4.2371 6.1873
BT-12 CTRP2 6.9867 7.8609 5.7504 0.2373
BT-16 CTRP2 7.7369 8.9514 5.6485 0.1684
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 4.0633 12.3705 1.1094 24.1228
A2780 CTRP2 2.2696 3.9432 2.2589 25.1841
TYK-nu CTRP2 2.4527 3.3149 2.4526 23.9289
OV-90 CTRP2 2.9059 5.1886 2.8092 21.2388
MCAS CTRP2 3.0227 4.2601 3.0175 20.1483
COV434 CTRP2 3.0728 4.9484 3.0218 19.9698
RMG-I CTRP2 3.4701 6.3505 3.1459 18.2962
TOV-112D CTRP2 3.6511 5.8528 3.4823 16.5305
SNU-8 CTRP2 4.2298 7.5153 3.5324 14.6791
IGROV-1 CTRP2 4.5009 6.5979 4.1819 11.4342
ONCO-DG-1 CTRP2 4.5132 7.9986 3.6149 13.6095
DOV13 CTRP2 4.8295 6.9059 4.4136 9.6306
OV7 CTRP2 4.8399 7.4361 4.198 10.4495
OAW28 CTRP2 5.0417 8.0488 4.1198 10.2583
HEY A8 CTRP2 5.3969 5.9143 5.3686 4.4109
OVISE CTRP2 5.685 7.5526 4.9732 5.2479
JHOS-2 CTRP2 5.7389 7.5953 5.0016 5.0107
OVK18 CTRP2 5.7828 7.509 5.0841 4.5717
JHOM-1 CTRP2 5.8128 9.1794 4.2799 7.8756
EFO-27 CTRP2 5.9568 28.1791 -5.096 33.1206
ES2 CTRP2 6.0653 8.0549 5.0565 4.1123
Kuramochi CTRP2 6.1612 11.0322 3.6472 9.8372
JHOC-5 CTRP2 6.1722 6.8839 5.7258 1.1118
OVCAR-4 CTRP2 6.2304 9.4738 4.4821 6.2163
Caov-3 CTRP2 6.2501 9.2946 4.5874 5.7384
OV56 CTRP2 6.2573 7.1659 5.6497 1.2906
OVCAR-5 CTRP2 6.6754 10.5699 4.2836 6.2672
OC 314 CTRP2 6.8421 8.416 5.439 1.3551
OVSAHO CTRP2 6.98 9.3924 5.0711 2.5983
COV362 CTRP2 6.98 9.59 4.9776 2.967
COV644 CTRP2 7.0537 10.4435 4.6186 4.3022
SNU-840 CTRP2 7.17 10.6324 4.6071 4.1828
SNU-119 CTRP2 7.2743 11.7796 4.1259 5.9721
OVCAR-8 CTRP2 7.2969 10.2662 4.8637 3.0023
FU-OV-1 CTRP2 7.436 24.9666 -2.2834 26.0077
OAW42 CTRP2 7.5248 8.5632 5.7066 0.1344
EFO-21 CTRP2 7.7673 9.6335 5.4016 0.6992
OVTOKO CTRP2 8.0679 14.7733 3.2295 8.3729
SK-OV-3 CTRP2 8.4525 16.0188 2.8933 9.1097
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SYO-1 CTRP2 5.6326 8.0217 4.6946 6.522
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 6.284 8.5253 4.9975 3.9592
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H CTRP2 2.6707 5.5575 2.4831 23.122
NCI-H28 CTRP2 3.3974 6.7779 2.9267 19.3187
ACC-MESO-1 CTRP2 4.4256 5.1789 4.4195 10.8051
NCI-H2052 CTRP2 5.465 8.0103 4.5449 7.518
MPP 89 CTRP2 5.9841 15.2889 1.3718 18.9424
NCI-H2452 CTRP2 6.3971 8.1631 5.2627 2.6646
IST-Mes1 CTRP2 9.9857 19.4596 2.268 9.3315
JL-1 CTRP2 15.4511 32.944 -0.6102 11.7786
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H660 CTRP2 1.076 15.062 -3.064 41.135
VCaP CTRP2 1.7218 2.4382 1.7218 28.7976
PaCa-3 CTRP2 3.9562 6.2292 3.7125 14.7713
22Rv1 CTRP2 4.4184 7.2181 3.8532 12.9222
DU145 CTRP2 5.8119 9.5202 4.1092 8.5928
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 CTRP2 6.2895 10.1388 4.1977 7.3002
YD-15 CTRP2 9.3502 16.4488 3.2711 6.535
Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Fu97 CTRP2 2.3876 5.4835 2.1916 25.0346
ECC10 CTRP2 2.4342 3.9239 2.4276 24.0736
SNU-16 CTRP2 3.2722 5.2614 3.1912 18.7445
HGC-27 CTRP2 3.4154 5.1595 3.3596 17.704
GSS CTRP2 3.8706 5.0616 3.8513 14.547
SNU-5 CTRP2 3.9377 5.6602 3.8376 14.3793
KE-39 CTRP2 4.0197 7.4131 3.3537 15.9423
MKN74 CTRP2 4.3317 7.1197 3.8016 13.3588
SNU-1 CTRP2 4.4089 6.8184 4.0014 12.3786
NCI-N87 CTRP2 4.5329 10.5337 2.4424 18.205
HuG1-N CTRP2 4.7439 9.678 3.0557 15.2872
SNU-216 CTRP2 4.8537 6.2846 4.6722 8.579
KATO III CTRP2 4.926 8.8154 3.644 12.4738
MKN7 CTRP2 4.9411 7.3703 4.3304 9.6619
SNU-620 CTRP2 5.0049 8.4824 3.8788 11.3283
NUGC-4 CTRP2 5.0499 6.4697 4.8192 7.4623
23132/87 CTRP2 5.2027 7.7771 4.4052 8.7074
SNU-719 CTRP2 5.3014 12.0047 2.4245 16.5249
AGS CTRP2 5.3093 9.6861 3.5797 11.8616
NUGC-3 CTRP2 5.4744 8.4112 3.7046 5.2007
OCUM-1 CTRP2 5.6094 8.6619 4.3575 7.9774
SNU-668 CTRP2 6.3326 10.8855 3.8596 8.6338
MKN45 CTRP2 6.5102 8.7595 5.0528 3.3507
IM95 CTRP2 6.5642 12.4974 3.2402 10.764
GSU CTRP2 6.9177 7.6182 5.8133 0.133
Hs 746.T CTRP2 7.1781 11.9743 3.963 6.7795
LMSU CTRP2 7.3451 10.5192 4.7758 3.2822
ECC12 CTRP2 7.6069 12.0039 4.2446 5.0242
SH-10-TC CTRP2 8.4496 9.5945 5.6806 0.0342
SNU-601 CTRP2 9.5557 26.5151 -1.4325 20.7986
MKN1 CTRP2 10.0362 30.3492 -2.963 23.3982
SNG-M CTRP2 5.6285 7.7176 4.8402 5.9262
SNU-1077 CTRP2 7.8648 12.0001 4.4123 4.0382
SNU-685 CTRP2 7.9033 11.9544 4.4574 3.8196
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW579 CTRP2 4.8103 14.2475 0.8739 23.1039
ML-1 [Human leukemia] CTRP2 4.9765 8.0953 4.0341 10.765
FTC-238 CTRP2 5.4494 9.7123 3.6937 11.0849
B-CPAP CTRP2 6.1971 9.5818 4.4013 6.6167
8505C CTRP2 6.3136 9.5958 4.4877 6.0415
CGTH-W-1 CTRP2 6.4564 9.4723 4.6605 5.0687
8305C CTRP2 6.4743 8.7877 5.0124 3.5754
TT CTRP2 6.4896 15.6423 1.6112 17.1216
FTC-133 CTRP2 6.6227 8.6083 5.2066 2.5496
CAL-62 CTRP2 7.1422 8.503 5.5646 0.6474
TT2609-C02 CTRP2 7.5109 10.647 4.8201 2.9091
BHT-101 CTRP2 8.1694 9.4626 5.6285 0.1046
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-10B CTRP2 0.9952 7.4971 0.0786 36.2581
HSC-2 CTRP2 4.0628 5.5196 3.9992 13.4188
HSC-4 CTRP2 4.3842 5.3507 4.3644 11.1272
SNU-1041 CTRP2 4.5503 6.9809 4.0885 11.6514
HSC-3 CTRP2 4.5897 5.2113 4.5864 9.7022
FaDu CTRP2 4.8274 6.4085 4.6016 8.9189
SNU-1214 CTRP2 5.0163 6.8282 4.6417 8.2375
PE/CA-PJ41 (clone D2) CTRP2 5.0213 7.3252 4.4323 9.0501
BICR 18 CTRP2 5.1404 8.3446 4.0752 10.2043
YD-8 CTRP2 5.4737 12.8241 2.168 17.1345
SCC-4 CTRP2 5.5934 6.97 5.1674 4.6605
SCC-25 CTRP2 5.9558 7.8373 5.0731 4.2571
Detroit 562 CTRP2 6.1211 8.6583 4.8008 5.0812
SNU-46 CTRP2 6.326 10.0979 4.2473 7.026
BICR 31 CTRP2 6.4143 7.9525 5.3783 2.1615
CAL-27 CTRP2 6.4708 7.8853 5.4505 1.7834
PE/CA-PJ34 (clone C12) CTRP2 6.4753 8.4804 5.1642 2.9466
BICR 22 CTRP2 6.554 8.0231 5.4407 1.7058
CAL-33 CTRP2 6.7157 10.3513 4.4216 5.6292
PE/CA-PJ49 CTRP2 6.7541 9.0701 5.0743 2.8943
SNU-1066 CTRP2 6.7637 12.6487 3.3209 10.0825
SCC-9 CTRP2 6.9861 11.4238 4.0934 6.5473
BHY CTRP2 6.9876 9.8101 4.8777 3.3544
PE/CA-PJ15 CTRP2 7.2064 9.8393 5.0058 2.5664
SNU-899 CTRP2 7.7489 8.8984 5.6718 0.1315
BICR 56 CTRP2 7.7641 21.2311 -0.1677 20.3944
BICR 16 CTRP2 8.0277 17.7368 1.7574 13.9115
SNU-1076 CTRP2 11.717 23.7758 1.3418 10.2931
BICR 6 CTRP2 13.5602 29.2351 -0.047 12.2382
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KMBC-2 CTRP2 2.7284 4.1096 2.722 22.113
KU-19-19 CTRP2 3.3867 5.1923 3.3244 17.9176
UM-UC-3 CTRP2 3.4339 4.688 3.4222 17.4308
RT-4 CTRP2 3.4457 7.2034 2.8249 19.5595
SW1710 CTRP2 4.7349 7.1784 4.2011 10.7133
UM-UC-1 CTRP2 4.9907 6.7719 4.6379 8.3219
U-BLC1 CTRP2 5.5938 7.4761 4.9254 5.6521
5637 CTRP2 5.8331 11.6241 3.0766 12.8248
647V CTRP2 6.0777 6.8001 5.694 1.4099
HT-1197 CTRP2 6.1428 7.5348 5.3795 2.6105
253J CTRP2 6.1603 7.188 5.5661 1.7976
JMSU-1 CTRP2 6.215 8.4561 4.9776 4.1656
BC-3C CTRP2 6.2758 9.8895 4.3111 6.8501
SCaBER CTRP2 6.456 8.382 5.1983 2.8363
HT-1376 CTRP2 6.7046 10.4927 4.3436 5.97
RT-112 CTRP2 6.8146 11.2169 4.0686 6.9264
TCCSUP CTRP2 6.8845 10.0491 4.6916 4.2549
CAL-29 CTRP2 7.1622 10.6957 4.5714 4.3369
253J-BV CTRP2 7.4432 9.2524 5.4016 0.9215
639V CTRP2 7.4468 8.443 5.72 0.134
BFTC-905 CTRP2 7.8992 9.3302 5.5744 0.2445
J82 CTRP2 9.4264 18.1979 2.5021 9.223
T24 CTRP2 9.7322 15.9376 3.728 4.4864
VM-CUB-1 CTRP2 10.6709 22.7766 1.1483 12.1506
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 6.7863 13.4263 2.9521 11.5256

References

1 Synthesis and biological evaluation of 2-pyridyl-substituted pyrazoles and imidazoles as transforming growth factor-beta type 1 receptor kinase inhibitors, Bioorg. Med. Chem. Lett. 20(14):4228-4232 (2010).