Details of the Drug

General Information of Drug (ID: DM0PFNC)

Drug Name
AZD6738
Indication
Disease Entry ICD 11 Status REF
Small-cell lung cancer 2C25.Y Phase 2 [1]
Chronic lymphocytic leukaemia 2A82.0 Phase 1 [2]
Solid tumour/cancer 2A00-2F9Z Phase 1 [3]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 412.5
Logarithm of the Partition Coefficient (xlogp) 2.6
Rotatable Bond Count (rotbonds) 4
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 7
Chemical Identifiers
Formula
C20H24N6O2S
IUPAC Name
imino-methyl-[1-[6-[(3R)-3-methylmorpholin-4-yl]-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl]cyclopropyl]-oxo-lambda6-sulfane
Canonical SMILES
C[C@@H]1COCCN1C2=NC(=NC(=C2)C3(CC3)[S@](=N)(=O)C)C4=C5C=CNC5=NC=C4
InChI
InChI=1S/C20H24N6O2S/c1-13-12-28-10-9-26(13)17-11-16(20(5-6-20)29(2,21)27)24-19(25-17)15-4-8-23-18-14(15)3-7-22-18/h3-4,7-8,11,13,21H,5-6,9-10,12H2,1-2H3,(H,22,23)/t13-,29-/m1/s1
InChIKey
OHUHVTCQTUDPIJ-JYCIKRDWSA-N
Cross-matching ID
PubChem CID
54761306
TTD ID
D0H9DA
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Serine/threonine-protein kinase ATR (FRP1) TT8ZYBQ ATR_HUMAN Inhibitor [4]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1; GDSC2 2.6723 5.5238 1.6418 12.6804
SK-PN-DW GDSC1; GDSC2 -0.2993 3.3261 -0.6311 37.7373
ES1 GDSC1; GDSC2 -0.1243 2.7856 -0.3074 35.4372
EW-7 GDSC1; GDSC2 -0.0469 2.1347 -0.1115 34.1227
EW-12 GDSC2 0.2664 3.3535 -0.0213 32.0774
EW-22 GDSC1; GDSC2 0.372 3.3404 0.0976 30.9743
HuO9 GDSC1; GDSC2 0.7718 4.5689 0.1211 28.9255
EW-3 GDSC1; GDSC2 0.8339 4.4207 0.2436 28.0287
EW-1 GDSC1; GDSC2 0.9087 3.6124 0.6036 25.8163
A-673 GDSC1; GDSC2 0.9466 5.6088 -0.1197 29.2653
CADO-ES1 GDSC1; GDSC2 1.0454 4.4828 0.4462 26.0229
CAL-72 GDSC1; GDSC2 1.0881 5.6322 0.0163 27.9957
ES8 GDSC1; GDSC2 1.3937 4.3696 0.8612 22.2468
ES7 GDSC1; GDSC2 1.41 5.129 0.5661 23.798
ES4 GDSC1; GDSC2 1.5016 6.1946 0.1843 25.4125
TC-71 GDSC1; GDSC2 1.5225 3.9496 1.157 20.0355
EW-18 GDSC1; GDSC2 1.6582 4.9376 0.9054 20.8867
HOS GDSC1; GDSC2 1.7727 4.5283 1.1978 18.7437
EW-11 GDSC1; GDSC2 2.1049 7.1143 0.3357 22.2827
EW-16 GDSC1; GDSC2 2.1335 5.8902 0.9501 18.7705
EW-24 GDSC1; GDSC2 2.1582 7.3804 0.2567 22.4979
SK-ES-1 GDSC1; GDSC2 2.2097 6.5505 0.7076 19.8747
ES5 GDSC1; GDSC2 2.3412 6.252 0.9765 17.8561
CHSA0011 GDSC1; GDSC2 2.4341 8.5711 -0.0749 23.1688
NOS-1 [Human HNSCC] GDSC1; GDSC2 2.5435 10.0365 -0.7042 25.6095
SJSA-1 GDSC1; GDSC2 2.6402 7.7923 0.496 19.5333
NY GDSC1; GDSC2 2.7415 6.4586 1.247 14.8619
MG-63 GDSC1; GDSC2 3.1344 9.7676 -0.0585 20.7892
CHSA0108 GDSC1; GDSC2 3.2129 6.1244 1.8288 9.7675
ES6 GDSC1; GDSC2 3.3763 8.9606 0.5477 16.9172
EW-13 GDSC1; GDSC2 3.3784 7.6529 1.2033 13.138
MHH-ES-1 GDSC1; GDSC2 3.408 7.2007 1.4538 11.5287
U2OS GDSC1; GDSC2 3.473 7.6989 1.258 12.5352
SaOS-2 GDSC1; GDSC2 3.7507 7.0122 1.8208 8.315
CAL-78 GDSC2 3.874 8.0242 1.4136 10.4976
U-CH2 GDSC2 3.928 7.4075 1.7596 8.2435
CHSA8926 GDSC1; GDSC2 4.0056 9.6741 0.6961 14.3273
G-292 clone A141B1 GDSC1; GDSC2 4.0383 8.7152 1.1966 11.3714
HuO-3N1 GDSC1; GDSC2 4.0573 8.8256 1.1564 11.5594
H-EMC-SS GDSC1; GDSC2 4.353 6.8359 2.3319 3.8274
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 167 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1; GDSC2 0.1473 2.8574 -0.0278 32.7172
KE-37 GDSC1; GDSC2 -1.8545 0.0691 -1.8592 51.9329
NU-DUL-1 GDSC1; GDSC2 -1.8295 2.2183 -2.0417 51.4822
SU-DHL-5 GDSC1; GDSC2 -1.7754 0.6654 -1.7978 51.1267
NB4 GDSC1; GDSC2 -1.6731 0.8207 -1.7006 50.1227
Karpas-299 GDSC1; GDSC2 -1.4603 0.5413 -1.4698 48.0071
697 GDSC1; GDSC2 -1.2636 0.3704 -1.2668 46.0269
SUP-M2 GDSC1; GDSC2 -1.1742 0.6518 -1.1816 45.1446
BV-173 GDSC1; GDSC2 -1.0505 1.0362 -1.0693 43.9463
A3/Kawakami GDSC1; GDSC2 -1.0304 1.7239 -1.1059 43.9187
MOLT-16 GDSC1; GDSC2 -1.0047 0.2439 -1.0053 43.4207
SR GDSC1; GDSC2 -0.9789 2.3774 -1.1517 43.6792
JURL-MK1 GDSC1 -0.9139 1.625 -0.9716 52.7679
SIG-M5 GDSC2 -0.908 0.2877 -0.9085 42.45
NK-92MI GDSC2 -0.8334 0.3015 -0.8338 41.7011
MOLM-13 GDSC1; GDSC2 -0.7714 1.0617 -0.7836 41.1311
JeKo-1 GDSC1; GDSC2 -0.7588 1.0814 -0.7715 41.0072
HEL GDSC1; GDSC2 -0.6779 1.1628 -0.692 40.2028
HAL-01 GDSC1; GDSC2 -0.6517 2.3982 -0.8019 40.4649
RCH-ACV GDSC1; GDSC2 -0.5983 1.0201 -0.6055 39.3739
EHEB GDSC1 -0.5093 17.5875 -7.2104 49.4975
NALM-6 GDSC1; GDSC2 -0.5077 5.0602 -1.4339 41.3365
OCI-Ly7 GDSC1; GDSC2 -0.5003 1.0413 -0.5064 38.386
RPMI-8402 GDSC1; GDSC2 -0.4644 3.1008 -0.752 39.1454
MV4-11 GDSC1; GDSC2 -0.4292 1.3238 -0.4436 37.7121
ATN-1 GDSC1; GDSC2 -0.3903 1.4501 -0.41 37.3469
OCI-M1 GDSC1; GDSC2 -0.2877 1.3081 -0.2977 36.2722
CRO-AP2 GDSC1; GDSC2 -0.2845 2.4068 -0.4071 36.7536
DEL GDSC1; GDSC2 -0.2537 2.3427 -0.3631 36.3905
CCRF-CEM GDSC1; GDSC2 -0.2045 1.8395 -0.2456 35.587
EoL-1 GDSC1; GDSC2 -0.1751 2.7343 -0.3516 35.9085
KOPN-8 GDSC1; GDSC2 -0.1717 3.4296 -0.5207 36.5893
BALL-1 GDSC1; GDSC2 -0.1671 1.9009 -0.2122 35.2318
SCC-3 GDSC2 -0.1613 1.9018 -0.2061 35.1725
BONNA-12 GDSC2 -0.1588 4.7257 -0.935 37.9867
BC-3 GDSC2 -0.1058 1.9163 -0.1492 34.6106
P12-Ichikawa GDSC1; GDSC2 -0.0509 2.3942 -0.1535 34.3433
MEG-01 GDSC1; GDSC2 -0.0374 2.1779 -0.107 34.0521
KCL-22 GDSC1; GDSC2 -0.0238 1.8365 -0.0557 33.7329
SU-DHL-1 GDSC2 -0.0024 2.7498 -0.1673 34.1519
CML-T1 GDSC1; GDSC2 0.006 2.8648 -0.183 34.1798
BL-41 GDSC1; GDSC2 0.0173 1.4744 0.0083 33.2076
CMK GDSC1 0.0312 2.1338 -0.0283 41.4247
Loucy GDSC1; GDSC2 0.0315 1.6088 0.0169 33.0927
SUP-B8 GDSC1; GDSC2 0.0551 3.7398 -0.3655 34.7181
OCI-Ly19 GDSC1; GDSC2 0.16 3.9048 -0.3039 33.903
L-540 GDSC1; GDSC2 0.1633 3.3675 -0.1377 33.1485
DND-41 GDSC1; GDSC2 0.2223 2.5225 0.1191 31.6207
ARH-77 GDSC1; GDSC2 0.2388 2.3148 0.1691 31.2894
MOLT-4 GDSC1; GDSC2 0.2474 2.5797 0.1362 31.4097
WIL2 NS GDSC1; GDSC2 0.2578 2.2631 0.1964 31.0572
Jiyoye GDSC1; GDSC2 0.2728 3.1823 0.0314 31.7935
MOLM-16 GDSC1; GDSC2 0.3024 3.5632 -0.0423 31.9939
GA-10 GDSC1; GDSC2 0.3138 2.6134 0.2018 30.7503
Jurkat GDSC1; GDSC2 0.3197 3.3723 0.0316 31.5558
MHH-PREB-1 GDSC1; GDSC2 0.3208 2.4403 0.2385 30.5314
WSU-NHL GDSC1; GDSC2 0.343 3.0176 0.1487 30.8688
Namalwa GDSC1; GDSC2 0.3443 2.8884 0.1797 30.7081
GR-ST GDSC1; GDSC2 0.3777 4.9615 -0.4509 33.402
SKM-1 GDSC1; GDSC2 0.3875 1.749 0.3767 29.5019
TK [Human B-cell lymphoma] GDSC1; GDSC2 0.3922 2.6888 0.2726 30.005
OCI-AML-2 GDSC1; GDSC2 0.439 2.8472 0.2915 29.6782
MC116 GDSC1; GDSC2 0.45 3.4661 0.1472 30.3448
ALL-SIL GDSC1; GDSC2 0.4921 2.3612 0.4331 28.6971
SU-DHL-16 GDSC1; GDSC2 0.6246 2.6285 0.5344 27.5286
RPMI-8226 GDSC1; GDSC2 0.6457 2.9411 0.4958 27.6257
EM-2 GDSC1; GDSC2 0.6878 2.0943 0.6672 26.538
JVM-3 GDSC1; GDSC2 0.6905 3.5766 0.3768 28.0252
DG-75 GDSC1; GDSC2 0.6911 3.9706 0.2507 28.6633
QIMR-WIL GDSC1; GDSC2 0.7163 3.8722 0.311 28.2387
Ku812 GDSC1; GDSC2 0.7173 5.1312 -0.1591 30.501
DoHH2 GDSC2 0.7391 1.9007 0.7311 25.9593
LC4-1 GDSC1; GDSC2 0.7786 4.3683 0.2039 28.4851
Granta-519 GDSC1; GDSC2 0.7965 2.8854 0.6716 25.9866
Mono-Mac-6 GDSC1; GDSC2 0.8323 3.2739 0.6178 26.0984
CESS GDSC1; GDSC2 0.8387 2.6573 0.7601 25.3219
ML-2 GDSC1; GDSC2 0.8647 2.7105 0.779 25.0983
A4/Fukuda GDSC1; GDSC2 0.8821 4.3981 0.3038 27.5013
P31/FUJ GDSC1; GDSC2 0.9068 2.3147 0.8779 24.3826
KMS-12-BM GDSC2 0.9089 3.0868 0.7488 25.0462
TALL-1 [Human adult T-ALL] GDSC2 0.9119 5.0093 0.0955 28.403
SUP-B15 GDSC2 0.9823 3.9042 0.5888 25.5554
JSC-1 GDSC1; GDSC2 0.993 4.7271 0.2948 27.0419
K-562 GDSC1; GDSC2 1.0082 3.42 0.7694 24.4716
Raji GDSC1; GDSC2 1.0652 4.3911 0.5024 25.6382
SUP-HD1 GDSC1; GDSC2 1.0887 4.8934 0.3291 26.4379
JVM-2 GDSC1; GDSC2 1.0992 3.4278 0.8664 23.5303
L-363 GDSC1; GDSC2 1.1142 4.4933 0.5154 25.3506
TUR GDSC1; GDSC2 1.1182 2.9595 1.0053 22.6994
BE-13 GDSC1; GDSC2 1.1357 3.803 0.7893 23.7806
Karpas-231 GDSC1; GDSC2 1.1535 3.0218 1.0301 22.4012
H9 GDSC1; GDSC2 1.1911 3.792 0.8531 23.1837
MOLT-13 GDSC1; GDSC2 1.1999 3.259 1.023 22.2217
U-698-M GDSC1; GDSC2 1.232 3.5586 0.9724 22.3485
MHH-CALL-4 GDSC2 1.2342 6.2233 -0.0973 27.898
CTB-1 GDSC1; GDSC2 1.258 6.5128 -0.2053 28.2936
RS4;11 GDSC1; GDSC2 1.2649 3.5833 1.0005 22.046
PL-21 GDSC1; GDSC2 1.2659 4.3963 0.7147 23.6083
L-1236 GDSC1; GDSC2 1.3 5.6647 0.2195 26.0779
NKM-1 GDSC1; GDSC2 1.304 4.8575 0.5701 24.2279
P32/ISH GDSC1; GDSC2 1.3297 3.2288 1.1725 20.8157
SU-DHL-8 GDSC1; GDSC2 1.3931 3.0736 1.2792 19.9486
ST486 GDSC1; GDSC2 1.4193 4.6571 0.7736 22.6229
MHH-CALL-2 GDSC1; GDSC2 1.4531 3.8993 1.1 20.6577
NOMO-1 GDSC1; GDSC2 1.4705 4.5888 0.8553 21.951
BC-1 GDSC1; GDSC2 1.5105 4.5421 0.9165 21.4393
SUP-T1 GDSC1; GDSC2 1.5676 4.9302 0.8147 21.771
KMS-11 GDSC1; GDSC2 1.569 5.3885 0.6166 22.8621
MOLP-8 GDSC1; GDSC2 1.5719 4.6324 0.9441 21.0253
OCI-AML-5 GDSC1 1.5719 4.4518 1.0177 25.5637
EB2 GDSC1; GDSC2 1.589 5.4286 0.6192 22.7658
EJM GDSC1; GDSC2 1.5949 4.1075 1.1766 19.6122
Hs 445 GDSC1; GDSC2 1.6068 3.9877 1.2339 19.2375
OCI-AML-3 GDSC1; GDSC2 1.6319 4.2692 1.1538 19.5836
Ramos.2G6.4C10 GDSC1; GDSC2 1.6362 5.2308 0.755 21.8228
Kasumi-1 GDSC1; GDSC2 1.6508 4.9134 0.9081 20.9018
HT GDSC1; GDSC2 1.6617 7.4125 -0.2306 26.7574
P30/OHK GDSC1; GDSC2 1.6913 3.5159 1.4859 17.4571
THP-1 GDSC1; GDSC2 1.6984 5.4635 0.7148 21.7946
VAL GDSC1; GDSC2 1.8035 5.7044 0.7109 21.3978
Karpas-45 GDSC1; GDSC2 1.8373 4.061 1.4535 17.0034
Sc-1 GDSC1 1.8622 5.6373 0.8004 25.42
KG-1 GDSC2 1.9233 4.8161 1.2314 17.938
IM-9 GDSC1; GDSC2 1.9485 5.5021 0.9487 19.4826
KY821 GDSC1; GDSC2 1.9512 3.903 1.635 15.4817
MM1.S GDSC2 2.0037 6.4411 0.5627 21.4442
RPMI-6666 GDSC1; GDSC2 2.0146 4.8121 1.3268 17.0164
HC-1 GDSC1; GDSC2 2.0505 5.5781 1.015 18.7062
AMO1 GDSC1; GDSC2 2.0535 4.7179 1.4082 16.3831
CTV-1 GDSC1; GDSC2 2.1604 3.9647 1.835 13.4492
MLMA GDSC1; GDSC2 2.2621 6.9585 0.5593 20.5079
LAMA-84 GDSC1; GDSC2 2.2695 7.0294 0.5317 20.632
Karpas-1106P GDSC1; GDSC2 2.3207 6.4441 0.8642 18.5814
L-428 GDSC1; GDSC2 2.4193 4.4722 1.8905 12.081
MY-M12 GDSC2 2.4518 6.5454 0.9379 17.6889
Daudi GDSC1; GDSC2 2.4794 5.8561 1.2988 15.4483
PF-382 GDSC1; GDSC2 2.5138 5.5036 1.5014 14.0969
Reh GDSC1; GDSC2 2.534 5.5026 1.5212 13.9039
WSU-DLCL2 GDSC1; GDSC2 2.5596 7.5276 0.5543 19.4892
DB GDSC1; GDSC2 2.5618 8.3659 0.1414 21.6613
KM-H2 GDSC1; GDSC2 2.5754 5.877 1.3791 14.6255
NCI-H929 GDSC1; GDSC2 2.5856 5.8682 1.393 14.5058
MN-60 GDSC1; GDSC2 2.5933 7.445 0.6256 18.9794
JJN-3 GDSC1; GDSC2 2.7442 7.8297 0.5701 18.78
YT GDSC1; GDSC2 2.7471 5.4851 1.7305 11.8752
CA46 GDSC1; GDSC2 2.7787 7.0468 0.9894 16.2754
GDM-1 GDSC1; GDSC2 2.8086 6.5123 1.2811 14.4339
HDLM-2 GDSC1; GDSC2 2.9369 9.4965 -0.0918 21.5733
ALL-PO GDSC1; GDSC2 2.9532 6.3298 1.5006 12.6203
HL-60 GDSC1; GDSC2 3.1827 6.0109 1.8597 9.6646
RL GDSC1; GDSC2 3.2026 6.2849 1.7399 10.3563
SU-DHL-10 GDSC1; GDSC2 3.2054 5.7592 2.0049 8.6812
VL51 GDSC1; GDSC2 3.2385 7.3201 1.2529 13.2536
OPM-2 GDSC1; GDSC2 3.2579 6.4775 1.6905 10.4999
SU-DHL-4 GDSC1; GDSC2 3.2806 5.2686 2.3139 6.5033
KMOE-2 GDSC1; GDSC2 3.4348 6.2874 1.9322 8.4707
SU-DHL-6 GDSC1; GDSC2 3.5205 5.0303 2.6271 3.8547
HH [Human lymphoma] GDSC1; GDSC2 3.6158 7.6491 1.3981 11.2841
Farage GDSC1; GDSC2 3.7797 6.713 1.9912 7.1795
RC-K8 GDSC1; GDSC2 3.7931 9.0544 0.8383 14.1022
Karpas-422 GDSC1; GDSC2 3.8912 11.6565 -0.381 20.0855
U266B1 GDSC1; GDSC2 3.9981 6.0684 2.4631 3.7571
SK-MM-2 GDSC1; GDSC2 4.2217 6.601 2.358 3.9287
Karpas-620 GDSC1; GDSC2 4.2511 15.0372 -1.7805 24.6209
LP-1 GDSC1; GDSC2 4.3961 7.891 1.8588 6.5518
ME1 GDSC1; GDSC2 4.5743 10.5483 0.6919 12.9085
ROS-50 GDSC1; GDSC2 5.0056 10.5259 1.0082 10.1743
⏷ Show the Full List of 167 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESO-51 GDSC1; GDSC2 -0.0318 3.8735 -0.5023 35.7445
KYSE-220 GDSC1; GDSC2 0.5087 3.6822 0.1463 30.0612
HCE-4 GDSC1; GDSC2 1.7764 4.7941 1.0894 19.3535
OACP4 C GDSC1; GDSC2 1.8403 7.6508 -0.1743 25.8049
KYSE-50 GDSC1; GDSC2 2.2926 8.2567 -0.0483 23.538
TE-12 GDSC1; GDSC2 2.4214 5.658 1.3389 15.4127
SK-GT-4 GDSC1; GDSC2 2.6204 7.6986 0.5246 19.4447
ESO-26 GDSC1; GDSC2 3.1926 6.2743 1.7367 10.4065
FLO-1 GDSC1; GDSC2 3.396 7.5964 1.2461 12.8286
OACM5.1 C GDSC1; GDSC2 3.5199 7.6678 1.3117 12.0773
KYAE-1 GDSC1; GDSC2 3.6006 6.818 1.8004 8.8397
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1; GDSC2 2.1634 6.2789 0.7939 19.5568
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
GOTO GDSC1; GDSC2 -0.8661 1.3831 -0.8998 42.1614
SK-N-MC-IXC GDSC1; GDSC2 -0.4212 2.0308 -0.4966 37.9048
KP-N-YN GDSC1; GDSC2 -0.0677 2.1703 -0.1383 34.3596
KP-N-YS GDSC2 0.3059 2.1343 0.2626 30.4842
MHH-NB-11 GDSC2 0.4913 2.6084 0.3942 28.8993
CHP-212 GDSC2 0.5905 2.9818 0.4266 28.2493
SK-N-DZ GDSC1; GDSC2 0.5998 2.3571 0.5483 27.5784
Kelly GDSC1; GDSC2 0.6925 2.8911 0.5574 27.0808
CHP-134 GDSC2 0.7164 2.4902 0.6548 26.4605
IMR-5 GDSC1; GDSC2 0.8396 3.0906 0.6723 25.777
SiMa GDSC1; GDSC2 0.8505 3.1342 0.6736 25.7186
SJNB-5 GDSC1; GDSC2 0.9306 3.885 0.5393 26.0544
NH-12 GDSC1; GDSC2 0.9942 5.2034 0.1018 28
SJNB-14 GDSC1; GDSC2 0.9985 2.7932 0.9086 23.7787
CHP-126 GDSC1; GDSC2 1.0716 4.0792 0.6244 24.9598
SJNB-13 GDSC1; GDSC2 1.2359 2.5441 1.2011 21.1108
SK-N-AS GDSC1; GDSC2 1.2653 4.7794 0.5615 24.441
NB69 GDSC1; GDSC2 1.3107 4.1571 0.8533 22.6518
SK-N-BE(2)-M17 GDSC1; GDSC2 1.5892 3.4707 1.3883 18.4547
SJNB-17 GDSC1; GDSC2 1.6419 4.0658 1.2426 19.0368
SJNB-10 GDSC1; GDSC2 1.6772 4.2588 1.2061 19.0942
SK-N-FI GDSC1; GDSC2 2.35 6.4887 0.8702 18.4416
GI-ME-N GDSC1; GDSC2 2.4228 5.5156 1.4083 14.9884
SK-N-SH GDSC1; GDSC2 2.5439 5.9896 1.2948 15.2468
SJNB-12 GDSC1; GDSC2 2.6865 8.9081 -0.0169 22.028
TGW GDSC1; GDSC2 3.1927 4.6017 2.5714 5.1418
SJNB-6 GDSC1; GDSC2 3.4234 6.1973 1.9679 8.2786
LA-N-6 GDSC1; GDSC2 3.6667 6.8125 1.855 8.3219
NB1 GDSC1; GDSC2 3.7094 10.335 0.1328 18.1317
NB(TU)1 GDSC1; GDSC2 3.8806 7.8763 1.4919 10.0047
KP-N-RT-BM-1 GDSC2 3.9234 7.9859 1.4702 10.0264
SJNB-7 GDSC1; GDSC2 4.21 8.8169 1.2748 10.4781
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1; GDSC2 1.1031 4.3498 0.5586 25.1702
Cancer Drug Sensitivity Data Curated from 52 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC1806 GDSC1; GDSC2 -0.6624 1.1661 -0.6762 40.0465
HCC1569 GDSC1; GDSC2 -0.0372 3.9787 -0.5423 35.9307
MDA-MB-157 GDSC1; GDSC2 0.0094 2.1162 -0.0493 33.5314
CAL-51 GDSC1; GDSC2 0.1193 2.1502 0.0632 32.4185
HCC1599 GDSC1; GDSC2 0.4741 5.7466 -0.6693 33.7831
CAL-148 GDSC2 0.7509 5.0445 -0.0885 30.0204
JIMT-1 GDSC1; GDSC2 1.0078 3.1581 0.8393 24.1004
HCC1395 GDSC1; GDSC2 1.0808 4.6486 0.4192 26.0061
MDA-MB-453 GDSC1; GDSC2 1.3316 3.3203 1.1502 20.9274
HCC70 GDSC1; GDSC2 1.365 5.1738 0.5004 24.341
BT-549 GDSC1; GDSC2 1.5148 5.6446 0.4473 23.9971
DU4475 GDSC1; GDSC2 1.525 4.1385 1.09 20.401
HCC1143 GDSC1; GDSC2 1.5351 4.6268 0.9078 21.3841
Hs 578T GDSC1; GDSC2 1.9241 7.8668 -0.1995 25.6031
COLO 824 GDSC1; GDSC2 2.0322 5.7034 0.9386 19.2189
MDA-MB-361 GDSC1; GDSC2 2.3597 5.429 1.3884 15.3383
MDA-MB-468 GDSC1; GDSC2 2.498 9.6452 -0.5501 25.1133
HCC38 GDSC1; GDSC2 2.5157 9.781 -0.6019 25.2742
MRK-nu-1 GDSC1; GDSC2 2.6258 4.9376 1.8798 11.377
YMB-1-E GDSC2 2.6741 6.1992 1.3132 14.6878
MCF-7 GDSC1; GDSC2 2.6752 5.8908 1.4654 13.7555
CAL-120 GDSC1; GDSC2 2.9105 6.58 1.3385 13.7527
MFM-223 GDSC1; GDSC2 3.1735 6.5696 1.5728 11.487
BT-20 GDSC1; GDSC2 3.2522 10.3501 -0.2504 21.3411
HDQ-P1 GDSC1; GDSC2 3.2623 9.2169 0.3246 18.457
CAL-85-1 GDSC1; GDSC2 3.3129 6.8737 1.5386 11.2826
MDA-MB-231 GDSC1; GDSC2 3.361 6.0683 1.9812 8.3725
CAMA-1 GDSC1; GDSC2 3.5155 6.3087 1.9867 7.9036
OCUB-M GDSC1; GDSC2 3.5157 7.1806 1.5515 10.6206
HCC1187 GDSC1; GDSC2 3.5657 5.7715 2.294 5.833
HCC1937 GDSC1; GDSC2 3.6551 8.4017 1.0541 13.2351
HCC1954 GDSC1; GDSC2 3.6734 9.7553 0.3932 16.8858
HCC2157 GDSC1; GDSC2 3.7127 7.812 1.3937 11.0464
AU565 GDSC1; GDSC2 3.7209 7.6013 1.5049 10.3456
BT-474 GDSC1; GDSC2 3.7565 5.7191 2.4634 4.2947
EFM-192A GDSC1; GDSC2 3.7962 6.0074 2.351 4.8981
MDA-MB-415 GDSC1; GDSC2 3.8517 7.391 1.7103 8.7398
UACC-812 GDSC2 3.9798 7.0316 1.9827 6.7409
Evsa-T GDSC1; GDSC2 4.0203 7.543 1.7613 8.0059
HCC1419 GDSC1; GDSC2 4.0444 6.1868 2.4376 3.8138
HCC202 GDSC1 4.0873 7.5481 1.8078 9.3639
EFM-19 GDSC1; GDSC2 4.1427 9.1325 1.0691 11.8515
BT-483 GDSC1; GDSC2 4.376 8.1013 1.7435 7.2878
MDA-MB-436 GDSC1; GDSC2 4.4028 10.5703 0.5544 14.0748
HCC1428 GDSC1; GDSC2 4.4223 8.4477 1.608 7.9954
HCC2218 GDSC1; GDSC2 4.4582 10.1296 0.8124 12.5265
HCC1500 GDSC1; GDSC2 4.583 9.3745 1.2713 9.6168
ZR-75-30 GDSC1; GDSC2 4.6543 6.9439 2.4638 2.5683
MDA-MB-330 GDSC1; GDSC2 4.744 11.5589 0.3202 14.4672
UACC-893 GDSC1; GDSC2 4.7453 15.7861 -1.7673 23.3396
MDA-MB-175-VII GDSC1; GDSC2 4.9976 13.1726 -0.2863 16.8112
T-47D GDSC1; GDSC2 5.0979 10.2642 1.196 8.9286
⏷ Show the Full List of 52 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 55 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D283 Med GDSC1; GDSC2 -1.4223 0.4492 -1.4287 47.6223
ONS-76 GDSC1; GDSC2 -0.2376 2.3122 -0.3409 36.2034
8-MG-BA GDSC1; GDSC2 0.0317 2.2282 -0.04 33.3716
SF539 GDSC1; GDSC2 0.3754 2.9877 0.191 30.4977
LNZTA3WT4 GDSC1 0.3793 2.8969 0.2158 37.6684
D-423MG GDSC1; GDSC2 0.5582 6.3738 -0.8524 34.0509
SW1783 GDSC1; GDSC2 0.6398 5.7335 -0.4912 32.2916
H4 GDSC1; GDSC2 0.8419 4.7949 0.1077 28.6651
LN-229 GDSC1; GDSC2 0.8892 3.5492 0.6017 25.9167
GI-1 GDSC1; GDSC2 0.9816 3.4198 0.7405 24.7494
T98G GDSC1; GDSC2 1.2147 3.0805 1.0834 21.83
Becker GDSC1; GDSC2 1.3268 3.2212 1.1713 20.836
LN-18 GDSC1; GDSC2 1.5306 3.7229 1.2444 19.512
SF295 GDSC1; GDSC2 1.6249 5.6525 0.5552 22.9686
D-566MG GDSC1; GDSC2 1.6761 4.923 0.9301 20.6733
KALS-1 GDSC1; GDSC2 1.7599 5.1521 0.9163 20.4121
Daoy GDSC1; GDSC2 1.7756 4.3237 1.2846 18.2317
PFSK-1 GDSC1; GDSC2 1.7773 5.0347 0.9858 19.9447
SF126 GDSC1; GDSC2 1.9362 4.2054 1.5019 16.3096
MOG-G-UVW GDSC1; GDSC2 1.942 4.8446 1.2382 17.8238
SW1088 GDSC1; GDSC2 1.9736 5.4075 1.0172 18.9891
D-336MG GDSC1; GDSC2 2.131 5.5778 1.0946 17.9363
Hs 683 GDSC1; GDSC2 2.2203 5.0946 1.4073 15.7432
42-MG-BA GDSC1; GDSC2 2.27 6.675 0.7044 19.6731
A-172 GDSC1; GDSC2 2.3012 5.6581 1.2229 16.545
YKG-1 GDSC1; GDSC2 2.4358 5.7136 1.326 15.4398
AM-38 GDSC1; GDSC2 2.7025 8.4133 0.2433 20.665
NMC-G1 GDSC1; GDSC2 2.8112 6.3597 1.3589 13.9517
U-118MG GDSC1; GDSC2 2.8365 6.2774 1.4224 13.4798
YH-13 GDSC1; GDSC2 2.856 6.1142 1.5207 12.8107
GaMG GDSC1; GDSC2 2.8814 6.1833 1.5093 12.7982
D-502MG GDSC1; GDSC2 2.8915 9.2068 0.0135 21.2062
SK-MG-1 GDSC1; GDSC2 2.9518 6.6641 1.3332 13.6532
D-263MG GDSC1; GDSC2 2.9929 6.1154 1.6423 11.615
M059J GDSC1; GDSC2 2.9962 5.6662 1.8684 10.1916
KNS-81-FD GDSC1; GDSC2 3.0307 6.8088 1.3302 13.4213
GB-1 GDSC1; GDSC2 3.1434 8.8654 0.4001 18.4224
CAS-1 GDSC1; GDSC2 3.1605 7.6299 1.032 14.8111
MOG-G-CCM GDSC1; GDSC2 3.3001 7.3543 1.2875 12.8601
U-87MG ATCC GDSC1; GDSC2 3.3182 7.7999 1.0798 14.0521
KS-1 [Human Krukenberg tumour] GDSC1; GDSC2 3.3407 8.0197 0.9886 14.5229
D-245MG GDSC2 3.371 7.9328 1.0572 14.03
SF268 GDSC1; GDSC2 3.3905 6.1658 1.9568 8.4417
D-542MG GDSC1; GDSC2 3.4532 7.9777 1.1025 13.5224
Onda 11 GDSC1; GDSC2 3.5302 8.8463 0.7313 15.4475
D-247MG GDSC1; GDSC2 3.5433 6.8268 1.7504 9.3081
DBTRG-05MG GDSC1; GDSC2 3.6252 6.6527 1.902 8.1382
LN-405 GDSC1; GDSC2 3.6254 8.2495 1.1062 13.0111
U-251MG GDSC1; GDSC2 3.6966 6.6343 1.9667 7.5452
SNB-75 GDSC1; GDSC2 3.7824 8.4421 1.1347 12.411
Onda 10 GDSC1; GDSC2 3.9864 6.6446 2.1766 5.5309
D-392MG GDSC1; GDSC2 4.0273 7.7682 1.6558 8.635
KNS-42 GDSC1; GDSC2 4.4485 9.0995 1.3097 9.7025
KINGS-1 GDSC1; GDSC2 4.6915 7.6328 2.1728 4.1223
DK-MG GDSC1; GDSC2 4.784 10.0563 1.0816 10.2506
⏷ Show the Full List of 55 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1; GDSC2 0.3541 3.6625 -0.0159 31.6086
TGBC24TKB GDSC1; GDSC2 1.6312 4.5009 1.0604 20.1179
TGBC1TKB GDSC1; GDSC2 2.9468 8.3822 0.4727 18.6516
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MFE-319 GDSC1; GDSC2 0.6948 3.6853 0.348 28.1525
ESS-1 GDSC1; GDSC2 0.9208 2.8346 0.8167 24.6321
RL95-2 GDSC1; GDSC2 2.5657 6.4011 1.1142 16.2551
AN3-CA GDSC1; GDSC2 2.6961 6.3002 1.2837 14.7925
MFE-296 GDSC1; GDSC2 3.1771 7.1662 1.2778 13.2882
KLE GDSC1; GDSC2 3.5252 7.558 1.3708 11.7029
MFE-280 GDSC1; GDSC2 3.8798 8.136 1.3626 10.7905
EN GDSC1; GDSC2 4.1996 9.1231 1.1163 11.4338
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ACHN GDSC1; GDSC2 -0.124 3.3094 -0.4353 35.9797
BFTC-909 GDSC1; GDSC2 0.1573 2.8485 -0.0149 32.6044
LB1047-RCC GDSC1; GDSC2 0.1749 3.8442 -0.2681 33.6702
LB2241-RCC GDSC1; GDSC2 0.2045 2.5572 0.0939 31.8348
769-P GDSC1; GDSC2 0.3894 3.2493 0.1411 30.6745
BB65-RCC GDSC1; GDSC2 0.4207 4.3452 -0.1727 31.9972
KTCTL-140 GDSC1; GDSC2 0.6924 3.8199 0.3023 28.3966
A-498 GDSC1; GDSC2 1.0308 5.9056 -0.1622 29.0832
KTCTL-13 GDSC1; GDSC2 1.2914 4.0399 0.8754 22.6143
786-O GDSC1; GDSC2 1.3252 4.527 0.7266 23.2858
KTCTL-1M GDSC1; GDSC2 1.6258 5.603 0.5784 22.8386
KTCTL-26A GDSC1; GDSC2 1.7987 5.9152 0.609 21.9805
NCC010 GDSC1; GDSC2 1.9487 5.2233 1.0761 18.7442
A-704 GDSC1; GDSC2 2.1627 5.9474 0.9514 18.6542
UO-31 GDSC1; GDSC2 2.1769 4.6762 1.5529 15.0406
TK-10 GDSC1; GDSC2 2.1932 5.5638 1.1622 17.3046
Caki-1 GDSC1; GDSC2 2.2156 7.2577 0.3701 21.6955
LB996-RCC GDSC1; GDSC2 2.2544 5.3488 1.3232 16.1183
HA7-RCC GDSC1; GDSC2 2.3079 5.7724 1.175 16.8057
CAL-54 GDSC1; GDSC2 2.4323 5.7516 1.3044 15.5827
RXF 393L GDSC1; GDSC2 2.5206 8.0325 0.2695 21.1456
KMRC-1 GDSC1; GDSC2 2.8573 6.9265 1.1192 15.2491
OS-RC-2 GDSC1; GDSC2 2.9024 8.9896 0.1313 20.5823
KTCTL-195 GDSC1; GDSC2 3.1165 6.1762 1.7202 10.7425
SW13 GDSC1; GDSC2 3.4128 7.8429 1.1367 13.4358
NCC021 GDSC1; GDSC2 3.5398 10.9092 -0.2918 20.6757
SN12C GDSC1; GDSC2 3.5981 8.2064 1.1059 13.0896
KMRC-20 GDSC1; GDSC2 3.8599 7.6486 1.5889 9.4657
SW156 GDSC1; GDSC2 4.0627 7.0487 2.034 6.231
VMRC-RCZ GDSC1; GDSC2 4.084 8.1887 1.4908 9.4978
VMRC-RCW GDSC2 4.2595 8.9296 1.2559 10.4686
KTCTL-21 GDSC1; GDSC2 4.5895 16.7211 -2.3528 25.6007
RCC10RGB GDSC1; GDSC2 4.8783 10.8084 0.7831 11.6979
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 48 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 320HSR GDSC1; GDSC2 -0.1609 3.4498 -0.5147 36.5046
LS411N GDSC1; GDSC2 0.2575 3.334 -0.0257 32.1433
LoVo GDSC1; GDSC2 0.7427 3.3291 0.5052 27.1124
HCC2998 GDSC1; GDSC2 1.017 5.0448 0.1915 27.4548
RKO GDSC1; GDSC2 1.0573 2.5755 1.0071 22.9821
LS180 GDSC1; GDSC2 1.1493 3.7032 0.8367 23.4617
SNU-C5 GDSC1; GDSC2 1.1533 4.382 0.6 24.7255
HT-29 GDSC1; GDSC2 1.3226 4.477 0.7435 23.2041
CCK-81 GDSC1; GDSC2 1.3849 4.1811 0.924 21.9357
SNU-283 GDSC2 1.4679 4.1122 1.0387 20.9352
SK-CO-1 GDSC1; GDSC2 1.6027 5.2403 0.7165 22.1738
MDST8 GDSC1; GDSC2 1.6231 3.9857 1.2521 19.0639
T84 GDSC1; GDSC2 1.8208 6.2835 0.4591 22.7077
CL-11 GDSC1; GDSC2 1.9005 6.0521 0.6459 21.3802
SW48 GDSC1; GDSC2 2.1068 5.2381 1.2282 17.2407
GP5d GDSC1; GDSC2 2.302 4.6557 1.6892 13.7412
DiFi GDSC1; GDSC2 2.3408 5.2458 1.4563 14.9974
SW626 GDSC1; GDSC2 2.4624 6.3232 1.0561 16.9589
SNU-C2B GDSC1; GDSC2 2.5853 6.9717 0.8519 17.7249
HCT 116 GDSC1; GDSC2 2.7024 6.4498 1.2158 15.1811
HCT 15 GDSC1; GDSC2 2.7594 7.0349 0.9781 16.4059
LS1034 GDSC1; GDSC2 2.7735 6.9761 1.0198 16.1138
SW1463 GDSC1; GDSC2 2.9382 7.8569 0.7272 17.2705
SNU-407 GDSC1; GDSC2 2.9606 7.8372 0.7565 17.0326
NCI-H508 GDSC1; GDSC2 3.0262 5.4991 1.978 9.4074
LS513 GDSC1 3.0279 6.4796 1.4918 15.3898
NCI-H716 GDSC1; GDSC2 3.0361 6.9833 1.2479 13.9046
SW948 GDSC1; GDSC2 3.0397 13.3184 -1.9134 28.3975
RCM-1 [Human ESC] GDSC1; GDSC2 3.1379 8.9494 0.3534 18.6878
SW620 GDSC1; GDSC2 3.2286 7.0933 1.3579 12.6444
C2BBe1 GDSC1; GDSC2 3.3857 5.4474 2.3118 6.2122
SW1417 GDSC1; GDSC2 3.5779 7.2774 1.5532 10.4373
SNU-175 GDSC2 3.5997 7.4644 1.4774 10.8436
CaR-1 GDSC1; GDSC2 3.6522 7.1287 1.6862 9.4115
KM12 GDSC1; GDSC2 3.685 7.379 1.5875 9.9344
LS123 GDSC1; GDSC2 3.6982 9.7623 0.4097 16.7279
CW-2 GDSC1; GDSC2 3.7316 8.144 1.2432 11.9029
COLO205 GDSC1; GDSC2 3.8171 7.5325 1.6137 9.4241
SW837 GDSC1; GDSC2 3.8917 8.0226 1.4279 10.3648
HT115 GDSC1; GDSC2 3.8962 6.0133 2.4196 4.2438
NCI-H747 GDSC1; GDSC2 3.9467 6.5199 2.209 5.4227
SNU-C1 GDSC1; GDSC2 4.0614 10.041 0.557 14.9411
SW1116 GDSC1; GDSC2 4.095 7.7216 1.7284 8.0272
SNU-1040 GDSC1 4.2671 6.7339 2.3247 5.0238
HT-55 GDSC1; GDSC2 4.338 6.8984 2.293 4.0844
SNU-81 GDSC1; GDSC2 4.3576 10.2064 0.7 13.3968
SNU-61 GDSC1; GDSC2 4.6176 7.4491 2.2121 4.0304
COLO 678 GDSC1; GDSC2 5.1691 10.3488 1.203 8.743
⏷ Show the Full List of 48 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1; GDSC2 4.6765 9.5433 1.255 9.5002
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-398 GDSC1; GDSC2 1.1543 5.3616 0.2015 26.7967
HLE GDSC1; GDSC2 2.0699 6.7221 0.4918 21.5808
JHH-1 GDSC1; GDSC2 2.2001 5.7409 1.0855 17.7314
Hep 3B2.1-7 GDSC1; GDSC2 2.7395 7.6802 0.6402 18.4066
JHH-2 GDSC1; GDSC2 2.763 6.5248 1.2338 14.8705
HuH-1 GDSC1; GDSC2 2.7911 7.1097 0.9693 16.3523
SNU-387 GDSC1; GDSC2 3.1985 5.9029 1.9272 9.1918
SNU-423 GDSC1; GDSC2 3.2427 7.796 1.0185 14.6406
Huh-7 GDSC1; GDSC2 3.243 8.6119 0.6109 16.9705
JHH-6 GDSC1; GDSC2 3.4205 4.8744 2.6263 4.1262
Hep-G2/C3A GDSC1; GDSC2 3.5429 6.0764 2.1242 6.9631
SK-HEP-1 GDSC1; GDSC2 3.6402 6.8079 1.8366 8.5076
JHH-7 GDSC1; GDSC2 3.884 6.6298 2.1098 6.1838
JHH-4 GDSC1; GDSC2 4.5635 9.5986 1.1485 10.3714
SNU-449 GDSC1; GDSC2 5.1351 9.2264 1.7092 5.9534
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 186 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
EPLC-272H GDSC1; GDSC2 -0.5605 4.2143 -1.1885 41.05
NCI-H647 GDSC1; GDSC2 0.0313 2.9575 -0.1767 34.0172
LC-1/sq GDSC1; GDSC2 0.1219 3.3825 -0.1871 33.5884
NCI-H460 GDSC1; GDSC2 0.3433 3.9844 -0.1311 32.1976
CPC-N GDSC1; GDSC2 0.4881 3.1586 0.2723 29.534
HARA [Human squamous cell lung carcinoma] GDSC1; GDSC2 0.4918 3.8963 0.0594 30.5663
NCI-H2171 GDSC2 0.5827 2.3046 0.5365 27.723
NCI-H1648 GDSC1; GDSC2 0.754 4.637 0.0759 29.2284
NCI-H2196 GDSC2 0.8102 4.7571 0.089 28.9024
NCI-H2122 GDSC1; GDSC2 0.8483 2.1497 0.8304 24.9137
NCI-H1703 GDSC1; GDSC2 0.8831 4.8281 0.1383 28.3255
A-427 GDSC1; GDSC2 0.9297 3.8536 0.5489 26.008
NCI-H64 GDSC2 0.947 4.3944 0.3746 26.8408
LCLC-97TM1 GDSC1; GDSC2 0.9549 3.4815 0.6934 25.1243
HCC33 GDSC2 0.99 4.6759 0.3119 26.9679
COR-L23 GDSC1; GDSC2 1.0087 5.0222 0.1922 27.4887
RERF-LC-Sq1 GDSC1; GDSC2 1.0227 5.0495 0.1956 27.4092
NCI-H1876 GDSC1; GDSC2 1.0579 4.1252 0.5931 25.189
NCI-H838 GDSC1; GDSC2 1.0728 5.1365 0.212 27.1035
RERF-LC-MS GDSC1; GDSC2 1.0945 3.8999 0.7119 24.3857
NCI-H2023 GDSC1; GDSC2 1.1644 4.6955 0.489 25.2684
PC-14 GDSC1; GDSC2 1.1677 3.7272 0.849 23.3119
CAL-12T GDSC1; GDSC2 1.1891 6.4858 -0.2619 28.8415
LB647-SCLC GDSC1; GDSC2 1.2151 3.5559 0.9547 22.5219
HCC78 GDSC1; GDSC2 1.2295 5.8029 0.0863 27.0411
Calu-6 GDSC1; GDSC2 1.2306 3.6097 0.955 22.4494
NCI-H1734 GDSC2 1.252 3.6289 0.9722 22.2592
SBC-1 GDSC1; GDSC2 1.3084 3.1481 1.1694 20.9315
NCI-H847 GDSC1; GDSC2 1.3222 3.2093 1.1693 20.8681
NCI-H2110 GDSC1; GDSC2 1.3267 4.8025 0.6166 23.8792
NCI-H1155 GDSC1; GDSC2 1.4081 3.4719 1.1905 20.3585
NCI-H292 GDSC1; GDSC2 1.5015 6.859 -0.1244 26.9096
NCI-H1755 GDSC1; GDSC2 1.6505 6.7176 0.0882 25.2885
NCI-H1436 GDSC1; GDSC2 1.6553 5.0721 0.8441 21.2451
SBC-5 GDSC1; GDSC2 1.7066 4.0978 1.2998 18.4356
NCI-H82 GDSC1; GDSC2 1.7729 4.1726 1.3417 17.9155
NCI-H1341 GDSC1; GDSC2 1.7828 4.3837 1.2679 18.298
NCI-H1944 GDSC1; GDSC2 1.8116 5.2697 0.9165 20.2047
NCI-H23 GDSC1; GDSC2 1.8363 4.6929 1.1948 18.5007
NCI-H2373 GDSC1; GDSC2 1.9868 6.03 0.7409 20.5188
NCI-H720 GDSC1; GDSC2 2.0154 5.7008 0.9232 19.3719
NCI-H209 GDSC1; GDSC2 2.0655 5.6257 1.0077 18.6923
A-549 GDSC1; GDSC2 2.0787 6.6736 0.5235 21.3765
NCI-H250 GDSC2 2.0881 6.159 0.7785 19.9242
NCI-H1792 GDSC1; GDSC2 2.0884 4.511 1.534 15.5027
EMC-BAC-2 GDSC1; GDSC2 2.0902 7.1352 0.3118 22.462
NCI-H1568 GDSC1; GDSC2 2.3105 7.1238 0.524 20.5269
NCI-H322M GDSC1; GDSC2 2.3132 6.3987 0.879 18.5232
UMC-11 GDSC1; GDSC2 2.3756 6.5644 0.8574 18.4244
NCI-H524 GDSC1; GDSC2 2.4216 5.1682 1.572 13.9998
IST-SL1 GDSC1; GDSC2 2.4378 4.7784 1.7698 12.7387
NCI-H446 GDSC1; GDSC2 2.4385 5.3812 1.4875 14.4514
NCI-H1650 GDSC1; GDSC2 2.4569 7.6121 0.4193 20.5759
HOP-62 GDSC1; GDSC2 2.4987 5.3959 1.5386 13.9238
Lu-99A GDSC1; GDSC2 2.507 6.6955 0.9157 17.6253
NCI-H1355 GDSC1; GDSC2 2.5169 5.4366 1.5365 13.8717
NCI-H727 GDSC1; GDSC2 2.5491 6.5514 1.0253 16.8385
NCI-H2461 GDSC1; GDSC2 2.5572 6.1502 1.229 15.5971
NCI-H2009 GDSC1; GDSC2 2.591 7.2189 0.7352 18.3724
VMRC-LCD GDSC1; GDSC2 2.6665 4.3374 2.2008 9.2662
SBC-3 GDSC1; GDSC2 2.6712 6.063 1.3774 14.3069
NCI-H2030 GDSC1; GDSC2 2.6804 5.9005 1.4655 13.7367
NCI-H661 GDSC1; GDSC2 2.6889 5.8814 1.4827 13.6028
DMS 273 GDSC1; GDSC2 2.6895 5.9825 1.4337 13.901
EBC-1 GDSC1; GDSC2 2.7477 5.7005 1.6257 12.5221
NCI-H1793 GDSC1; GDSC2 2.7528 7.2745 0.8534 17.1529
COR-L279 GDSC1; GDSC2 2.7549 7.2456 0.8696 17.0527
COR-L32 GDSC1; GDSC2 2.7686 8.8385 0.09 21.2267
Lu-134-A GDSC1; GDSC2 2.7712 6.3437 1.3307 14.2555
LXF 289 GDSC1; GDSC2 2.8059 7.0612 1.0066 16.085
SK-MES-1 GDSC1; GDSC2 2.8151 6.6877 1.2 14.9027
BEN GDSC1; GDSC2 2.854 7.914 0.6252 18.1147
KNS-62 GDSC1; GDSC2 2.8685 7.324 0.9315 16.3207
NCI-H1963 GDSC2 2.8705 6.436 1.3743 13.6634
NCI-H2795 GDSC1; GDSC2 2.8706 5.8433 1.6679 11.8512
NCI-H211 GDSC1; GDSC2 2.8737 7.0234 1.0856 15.3963
NCI-H3122 GDSC1; GDSC2 2.8799 6.0578 1.5702 12.427
Ms-1 GDSC1; GDSC2 2.9008 6.8615 1.19 14.6837
NCI-H841 GDSC1; GDSC2 2.9413 6.8975 1.2078 14.4466
NCI-H1623 GDSC1; GDSC2 3.0112 5.5964 1.9163 9.843
NCI-H1694 GDSC1; GDSC2 3.0244 5.9107 1.7719 10.7064
NCI-H290 GDSC1; GDSC2 3.0286 6.6635 1.4008 12.9961
NCI-H810 GDSC1; GDSC2 3.0458 6.8129 1.3413 13.3062
NCI-H2170 GDSC1; GDSC2 3.1133 6.4432 1.5842 11.5998
HCC44 GDSC1; GDSC2 3.1179 5.7952 1.9114 9.5382
NCI-H1299 GDSC1; GDSC2 3.1389 6.7846 1.4358 12.4389
IST-SL2 GDSC1; GDSC2 3.1572 9.4491 0.12 19.8338
EMC-BAC-1 GDSC1; GDSC2 3.1688 5.4425 2.1315 7.994
NCI-H2810 GDSC1; GDSC2 3.1902 6.0546 1.8443 9.7387
NCI-H1993 GDSC1; GDSC2 3.2023 7.0645 1.35 12.7724
NCI-H146 GDSC1; GDSC2 3.2203 6.0705 1.8621 9.5361
NCI-H1437 GDSC1; GDSC2 3.2406 5.1325 2.348 6.4072
SW1573 GDSC1; GDSC2 3.241 6.4661 1.6819 10.6039
NCI-H1581 GDSC1; GDSC2 3.2463 6.2127 1.813 9.7667
HOP-92 GDSC1; GDSC2 3.247 6.6978 1.5711 11.2761
SW1271 GDSC1; GDSC2 3.2551 6.157 1.8483 9.5188
NCI-H2347 GDSC1; GDSC2 3.3058 6.7699 1.5844 11.0192
Lu-135 GDSC1; GDSC2 3.3108 7.277 1.3351 12.5389
NCI-H2731 GDSC1; GDSC2 3.313 7.131 1.41 12.0747
NCI-H748 GDSC2 3.3369 8.3498 0.8205 15.5077
NCI-H1048 GDSC1; GDSC2 3.3533 6.2947 1.8616 9.1475
NCI-H510A GDSC2 3.3648 6.2795 1.8787 9.0066
SK-LU-1 GDSC1; GDSC2 3.3696 7.9634 1.0409 14.1305
NCI-H2087 GDSC1; GDSC2 3.3853 6.229 1.9209 8.6825
NCI-H2291 GDSC1; GDSC2 3.4351 7.1492 1.5018 11.1557
NCI-H520 GDSC1; GDSC2 3.4462 7.6268 1.2721 12.5269
NCI-H1975 GDSC1; GDSC2 3.4469 12.1389 -0.9829 23.9115
NCI-H2369 GDSC1; GDSC2 3.4792 7.5579 1.3335 12.0599
NCI-H1651 GDSC1; GDSC2 3.4824 7.0836 1.5731 10.5808
NCI-H2804 GDSC1; GDSC2 3.4955 6.3164 1.9668 8.084
NCI-H2141 GDSC1; GDSC2 3.5135 9.3511 0.4655 16.9598
NCI-H2591 GDSC1; GDSC2 3.5207 8.7578 0.7679 15.2683
NCI-H2228 GDSC1; GDSC2 3.5414 8.4628 0.9321 14.2681
HCC827 GDSC1; GDSC2 3.5435 7.9942 1.1678 12.8753
NCI-H2227 GDSC1; GDSC2 3.5554 6.6786 1.8339 8.7533
DMS 114 GDSC1; GDSC2 3.5673 8.0022 1.183 12.7174
HCC366 GDSC1; GDSC2 3.586 13.4497 -1.5236 25.5275
COR-L311 GDSC2 3.5929 7.684 1.3624 11.5649
NCI-H2405 GDSC1; GDSC2 3.6015 5.789 2.3129 5.6205
LC-2/ad GDSC1; GDSC2 3.6081 6.8611 1.7848 8.9167
NCI-H358 GDSC1; GDSC2 3.6237 6.9853 1.7352 9.1837
COR-L303 GDSC2 3.6306 6.5752 1.9448 7.8557
NCI-H69 GDSC1; GDSC2 3.667 7.2982 1.6135 9.8219
NCI-H1915 GDSC1; GDSC2 3.6728 6.6746 1.9283 7.8476
NCI-H2066 GDSC1; GDSC2 3.6903 5.8184 2.3659 5.0626
COLO 668 GDSC1; GDSC2 3.6937 7.335 1.6162 9.7336
NCI-H1836 GDSC1; GDSC2 3.7031 7.5901 1.4966 10.4441
ABC-1 GDSC1; GDSC2 3.7099 9.1174 0.7408 14.8834
LK-2 GDSC1; GDSC2 3.7276 9.1874 0.72 14.9508
COR-L105 GDSC1; GDSC2 3.7318 9.9276 0.3541 16.927
NCI-H2085 GDSC1; GDSC2 3.7526 6.343 2.1536 6.2343
NCI-H1693 GDSC1; GDSC2 3.7654 7.0758 1.8006 8.4026
IA-LM GDSC1; GDSC2 3.7659 5.9316 2.366 4.8771
ChaGo-K-1 GDSC1; GDSC2 3.7713 6.5393 2.0706 6.7049
LCLC-103H GDSC1; GDSC2 3.8058 5.8399 2.4399 4.3253
NCI-H1573 GDSC1; GDSC2 3.8551 7.4685 1.6745 8.9521
Lu-139 GDSC1 3.8658 7.0186 1.905 9.3069
NCI-H2172 GDSC1; GDSC2 3.869 5.727 2.5391 3.5737
NCI-H1666 GDSC1; GDSC2 3.9003 9.1471 0.8762 13.5954
Calu-3 GDSC1; GDSC2 3.903 8.2471 1.3252 10.955
NCI-H2818 GDSC1; GDSC2 3.9032 7.8337 1.5303 9.7125
NCI-H345 GDSC1; GDSC2 3.9522 8.7649 1.1062 12.1263
NCI-H196 GDSC1; GDSC2 3.9764 6.8859 2.0515 6.3245
NCI-H835 GDSC1; GDSC2 3.9962 9.8996 0.5767 15.0079
NCI-H2803 GDSC1; GDSC2 4.0166 7.3639 1.8466 7.4912
LOU-NH91 GDSC1; GDSC2 4.0186 7.8716 1.5984 9.0067
NCI-H2342 GDSC1; GDSC2 4.0259 7.4265 1.8227 7.6159
NCI-H226 GDSC1; GDSC2 4.0259 6.6427 2.2053 5.2653
NCI-H596 GDSC1; GDSC2 4.0534 6.2244 2.4257 3.8671
PaCa-3 GDSC1; GDSC2 4.0586 7.5544 1.7838 7.7757
DMS 79 GDSC1; GDSC2 4.0612 8.3586 1.39 10.1614
NCI-H1563 GDSC1; GDSC2 4.0678 7.8561 1.6424 8.6173
NCI-H2444 GDSC1; GDSC2 4.0743 6.5735 2.2724 4.7489
NCI-H740 GDSC2 4.0913 12.5012 -0.6434 20.6995
NCI-H2081 GDSC1; GDSC2 4.1027 8.6311 1.2866 10.6748
NCI-H1105 GDSC1; GDSC2 4.1223 9.8544 0.6963 14.0184
NCI-H441 GDSC1; GDSC2 4.1329 8.5789 1.3349 10.3122
NCI-H1838 GDSC1; GDSC2 4.1651 9.0842 1.1097 11.5588
NCI-H2869 GDSC1; GDSC2 4.2314 9.1621 1.1208 11.3286
NCI-H1869 GDSC1; GDSC2 4.2698 8.4608 1.4933 9.0336
NCI-H1304 GDSC1 4.3065 6.4467 2.484 3.7775
COR-L88 GDSC1; GDSC2 4.3258 9.5618 0.994 11.8269
NCI-H650 GDSC1; GDSC2 4.347 6.3017 2.5748 2.4508
RERF-LC-KJ GDSC1; GDSC2 4.3695 6.7065 2.4026 3.3868
DMS 53 GDSC1; GDSC2 4.3935 9.2259 1.2083 10.4246
COR-L321 GDSC1; GDSC2 4.4696 7.4163 2.1339 4.7628
NCI-H2029 GDSC1; GDSC2 4.5156 7.0021 2.3558 3.393
NCI-H1092 GDSC1; GDSC2 4.5318 8.1519 1.8256 6.4611
NCI-H1781 GDSC1; GDSC2 4.5386 11.2386 0.3261 14.9387
COR-L95 GDSC1 4.5548 7.7792 2.0179 6.5487
SHP-77 GDSC1; GDSC2 4.6126 12.164 -0.075 16.7542
NCI-H2135 GDSC1; GDSC2 4.6152 11.7881 0.1123 15.832
Lu-65 GDSC1; GDSC2 4.6568 13.2339 -0.5703 18.9158
NCI-H1435 GDSC1; GDSC2 4.7448 8.8084 1.6547 7.0263
NCI-H3255 GDSC1; GDSC2 4.7539 14.1957 -0.9725 20.3632
NCI-H1688 GDSC1; GDSC2 4.7711 10.2217 0.9925 10.7822
NCI-H2722 GDSC1; GDSC2 4.7813 11.986 0.1377 15.2996
NCI-H513 GDSC1; GDSC2 4.7866 10.074 1.0749 10.283
NCI-H187 GDSC1 4.7957 6.5899 2.6914 1.5545
HCC15 GDSC1; GDSC2 4.8698 9.144 1.5778 7.2176
NCI-H522 GDSC1; GDSC2 4.8991 6.9003 2.6134 1.4893
NCI-H526 GDSC1; GDSC2 4.905 6.5964 2.7407 0.9296
EKVX GDSC1; GDSC2 5.0568 13.3206 -0.3156 16.8054
Lu-165 GDSC1; GDSC2 5.1062 10.8996 0.8972 10.5689
NCI-H2595 GDSC1; GDSC2 5.1126 7.7394 2.3666 2.4202
NCI-H1770 GDSC1; GDSC2 5.2878 13.0958 -0.0393 14.9804
⏷ Show the Full List of 186 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1; GDSC2 1.593 5.6025 0.5455 23.1505
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-140 GDSC1; GDSC2 -0.9044 2.9114 -1.1852 43.249
OE21 GDSC1; GDSC2 0.5139 5.3886 -0.4785 32.8431
TE-11 GDSC1; GDSC2 0.6759 2.6518 0.5857 27.0142
OE19 GDSC1; GDSC2 0.8527 5.3875 -0.1232 29.7083
OE33 GDSC1; GDSC2 0.9004 4.7338 0.194 27.9708
TE-10 GDSC1; GDSC2 0.9106 2.406 0.8724 24.3922
KYSE-180 GDSC1; GDSC2 1.2841 5.9126 0.093 26.775
TE-1 GDSC1; GDSC2 1.546 4.5504 0.9505 21.098
KYSE-270 GDSC1; GDSC2 1.7417 4.2759 1.2678 18.4696
TE-4 GDSC1; GDSC2 2.0111 7.2464 0.1831 23.4195
EC-GI-10 GDSC1; GDSC2 2.1538 5.8005 1.0123 18.3331
KYSE-510 GDSC1; GDSC2 2.2042 4.5981 1.6153 14.5629
TE-8 GDSC1; GDSC2 2.3985 5.1857 1.5411 14.2722
TE-6 GDSC1; GDSC2 2.9317 7.0436 1.1266 14.965
TE-9 GDSC1; GDSC2 3.0334 7.2283 1.1233 14.6623
TE-15 GDSC1 3.1052 7.8835 0.8581 19.4823
KYSE-410 GDSC1; GDSC2 3.2203 6.4719 1.6615 10.7935
TE-5 GDSC1; GDSC2 3.2879 6.8913 1.5088 11.5407
KYSE-520 GDSC1; GDSC2 3.3726 7.0596 1.4952 11.3762
KYSE-150 GDSC1; GDSC2 3.591 6.13 2.1353 6.7648
T.T GDSC1; GDSC2 3.6867 6.2134 2.1678 6.3115
KYSE-450 GDSC1; GDSC2 4.1208 8.4756 1.3768 10.0921
KYSE-70 GDSC1; GDSC2 4.2525 8.9564 1.2376 10.5937
COLO 680N GDSC1; GDSC2 4.6399 7.3895 2.2533 3.7561
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TOV-21G GDSC1; GDSC2 0.6701 4.879 -0.1078 30.4903
IGROV-1 GDSC2 0.7955 5.4521 -0.2101 30.3648
TYK-nu GDSC1; GDSC2 1.1465 4.4336 0.5729 24.9007
OVCAR-5 GDSC1; GDSC2 1.2445 3.8041 0.9069 22.6501
OC 314 GDSC1; GDSC2 1.3299 4.394 0.7837 22.9513
OVISE GDSC1; GDSC2 1.3856 5.5825 0.3434 25.0811
DOV13 GDSC1; GDSC2 1.4055 4.3518 0.8807 22.0878
Caov-3 GDSC2 1.4107 5.1823 0.544 23.9138
OVK18 GDSC1; GDSC2 1.4298 6.204 0.1082 26.0877
ES-2 GDSC1; GDSC2 1.4742 5.1118 0.64 23.127
TOV-112D GDSC1; GDSC2 1.9116 6.9206 0.2449 23.4807
Caov-4 GDSC1; GDSC2 1.9612 4.8 1.2774 17.5185
SK-OV-3 GDSC1; GDSC2 2.2023 7.5791 0.2009 22.6239
JHOS-4 GDSC1; GDSC2 2.2128 6.5224 0.724 19.7708
OV-90 GDSC1; GDSC2 2.3396 7.125 0.5504 20.2785
OVCAR-8 GDSC1; GDSC2 2.4456 4.6502 1.8365 12.3059
OVCAR-4 GDSC1; GDSC2 2.4967 7.122 0.6969 18.9128
RMG-I GDSC1; GDSC2 2.8165 6.7876 1.1517 15.1877
EFO-27 GDSC1; GDSC2 2.9876 8.8836 0.2578 19.6611
FU-OV-1 GDSC1; GDSC2 3.014 9.3543 0.0455 20.6559
OAW42 GDSC1; GDSC2 3.0951 6.4615 1.5593 11.8107
JHOS-2 GDSC1; GDSC2 3.1015 5.5148 2.0368 8.7998
OVTOKO GDSC1; GDSC2 3.5009 9.6589 0.3013 17.8673
OV56 GDSC1; GDSC2 3.6899 5.3567 2.5926 3.6517
OAW28 GDSC1; GDSC2 3.7579 9.3878 0.6442 15.2878
A2780 GDSC1; GDSC2 3.7736 10.4381 0.1329 17.9496
OVCAR-3 GDSC1; GDSC2 3.8152 7.5729 1.5923 9.5605
Kuramochi GDSC1; GDSC2 4.3495 9.7 0.9435 12.0562
EFO-21 GDSC1; GDSC2 4.3521 9.3736 1.1058 11.1196
OVKATE GDSC1; GDSC2 4.9765 7.9662 2.1907 3.5421
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PL4 GDSC1; GDSC2 1.0229 4.5681 0.3892 26.4217
Panc 03.27 GDSC1; GDSC2 1.2902 4.9865 0.5019 24.6524
DAN-G GDSC1; GDSC2 1.6982 4.9105 0.9584 20.4223
HuP-T3 GDSC1; GDSC2 1.8049 4.1604 1.3804 17.5587
HPAF-II GDSC1; GDSC2 2.4978 8.3127 0.1104 22.0373
CFPAC-1 GDSC1; GDSC2 2.7558 7.166 0.9098 16.8164
SW1990 GDSC1; GDSC2 2.7859 9.0939 -0.0221 21.725
SUIT-2 GDSC1; GDSC2 2.8382 6.1046 1.5094 12.9389
HuP-T4 GDSC1; GDSC2 3.0873 5.5637 2 9.0757
KP-4 GDSC1; GDSC2 3.1664 7.0657 1.3189 13.0709
Panc 02.03 GDSC1; GDSC2 3.1792 7.8342 0.9458 15.2594
PSN1 GDSC1; GDSC2 3.2304 6.6445 1.5837 11.2472
AsPC-1 GDSC1; GDSC2 3.359 7.4146 1.3064 12.5723
PaTu 8902 GDSC1; GDSC2 3.4814 6.0671 2.0799 7.41
HPAC GDSC1; GDSC2 3.4817 9.7629 0.2336 18.2748
YAPC GDSC1; GDSC2 3.4874 6.3322 1.9524 8.1969
MZ-PC-1 GDSC1; GDSC2 3.6216 9.2561 0.6007 15.9116
PaTu 8988t GDSC1; GDSC2 3.6584 7.532 1.4903 10.6033
Hs 766T GDSC1; GDSC2 3.6899 7.716 1.4236 10.9262
SU.86.86 GDSC1; GDSC2 3.7244 8.4866 1.0669 12.9687
Panc 08.13 GDSC1; GDSC2 3.7629 8.3878 1.1464 12.3942
Capan-1 GDSC1; GDSC2 3.7961 7.9574 1.3865 10.8663
Panc 10.05 GDSC1; GDSC2 3.82 7.5457 1.6094 9.4428
MIA PaCa-2 GDSC1; GDSC2 3.8727 8.2268 1.312 11.1136
BxPC-3 GDSC1; GDSC2 3.8802 9.0064 0.9304 13.3386
KP-1N GDSC1; GDSC2 4.2803 6.8876 2.2606 4.3896
Panc 04.03 GDSC1; GDSC2 4.431 11.6256 0.0543 16.5824
KP-2 GDSC1; GDSC2 4.6659 8.4834 1.757 6.5885
KP-3 GDSC1; GDSC2 4.7007 8.9855 1.5405 7.7863
QGP-1 GDSC1; GDSC2 5.1359 11.5473 0.6053 12.0748
Capan-2 GDSC1; GDSC2 5.2866 11.4345 0.7631 10.9086
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2452 GDSC1; GDSC2 1.2522 4.8103 0.5351 24.64
NCI-H28 GDSC1; GDSC2 2.2382 7.5589 0.2441 22.2722
MPP 89 GDSC1; GDSC2 2.4458 5.9235 1.2343 15.9559
MSTO-211H GDSC1; GDSC2 3.1028 5.506 2.0424 8.7604
IST-Mes1 GDSC1; GDSC2 3.733 7.2375 1.6953 9.14
NCI-H2052 GDSC2 4.1173 8.4686 1.3776 10.0958
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC GDSC1; GDSC2 1.267 6.1854 -0.047 27.5222
DU145 GDSC1; GDSC2 3.1291 6.4531 1.5929 11.4971
PC-3 GDSC1; GDSC2 3.3937 7.4886 1.2982 12.5207
22Rv1 GDSC1; GDSC2 3.726 7.9152 1.3527 11.2587
VCaP GDSC1; GDSC2 3.9487 6.8409 2.0535 6.3777
NCI-H660 GDSC2 4.317 6.8902 2.2833 4.1823
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1; GDSC2 2.7927 5.6562 1.6889 11.9789
Cancer Drug Sensitivity Data Curated from 57 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
G-mel GDSC1; GDSC2 -0.3402 2.1741 -0.4298 37.1615
RPMI-7951 GDSC1; GDSC2 0.4492 3.188 0.2224 29.9757
LOX-IMVI GDSC1; GDSC2 0.693 4.5482 0.0447 29.6664
CHL-1 GDSC1; GDSC2 0.8515 3.2777 0.6378 25.9024
WM793 GDSC1; GDSC2 0.9966 3.4975 0.7342 24.7129
SK-MEL-2 GDSC1; GDSC2 1.169 3.7791 0.8333 23.3911
IST-MEL1 GDSC1; GDSC2 1.24 3.8812 0.8758 22.8405
IPC-298 GDSC1; GDSC2 1.2468 3.3301 1.0551 21.8323
M14 GDSC1; GDSC2 1.2885 3.9858 0.8917 22.5376
IGR-37 GDSC1; GDSC2 1.3173 4.4296 0.7564 23.1562
COLO 800 GDSC1; GDSC2 1.4302 4.9454 0.6653 23.1732
A-431 GDSC1; GDSC2 1.4733 3.9072 1.1191 20.4626
COLO 679 GDSC1; GDSC2 1.5099 5.4796 0.5159 23.6513
DJM-1 GDSC1; GDSC2 1.6146 5.8761 0.4432 23.6114
SK-MEL-30 GDSC1; GDSC2 1.6677 4.9668 0.9026 20.864
A101D GDSC1; GDSC2 1.6857 5.2541 0.7953 21.3957
A2058 GDSC1; GDSC2 1.6903 3.8513 1.3731 18.0906
HT-144 GDSC1; GDSC2 2.0605 6.2074 0.7288 20.3085
A-375 GDSC1; GDSC2 2.1239 5.3538 1.1918 17.3903
WM278 GDSC1; GDSC2 2.231 6.3873 0.8065 19.2362
WT2-iPS GDSC1; GDSC2 2.3037 6.7365 0.7062 19.5416
A-388 GDSC1; GDSC2 2.4603 5.904 1.2575 15.7651
MZ-MEL-7 GDSC1; GDSC2 2.6394 5.945 1.4057 14.243
LB2518-MEL GDSC1; GDSC2 2.6934 6.2627 1.2997 14.7047
WM115 GDSC1; GDSC2 2.8859 6.3667 1.4224 13.3188
Mel Ho GDSC1; GDSC2 3.0036 7.7039 0.8603 16.3018
G-361 GDSC1; GDSC2 3.045 7.1681 1.1634 14.3859
Hs 938.T GDSC1; GDSC2 3.154 6.8658 1.4082 12.5624
IGR-1 GDSC1; GDSC2 3.2094 5.2993 2.2379 7.1975
WM35 GDSC1; GDSC2 3.366 8.4174 0.8108 15.4766
COLO 783 GDSC1; GDSC2 3.3678 5.5098 2.266 6.553
Mel JuSo GDSC1; GDSC2 3.376 5.453 2.3011 6.3079
SH-4 GDSC1; GDSC2 3.3797 9.0872 0.4873 17.2357
GAK GDSC1; GDSC2 3.4399 6.0422 2.0588 7.6582
WM1552C GDSC1; GDSC2 3.4533 7.343 1.4198 11.6079
MeWo GDSC1; GDSC2 3.4817 7.1356 1.5465 10.7473
RVH-421 GDSC1; GDSC2 3.515 9.9405 0.1721 18.4926
HMV-II GDSC1; GDSC2 3.5297 6.4751 1.9149 8.3156
COLO 829 GDSC1; GDSC2 3.5471 10.8757 -0.2689 20.5483
451Lu GDSC1; GDSC2 3.574 7.5814 1.3985 11.3973
SK-MEL-5 GDSC1; GDSC2 3.5831 9.1353 0.6299 15.8607
Hs 940.T GDSC1; GDSC2 3.5853 5.9456 2.2226 6.2303
SK-MEL-28 GDSC1; GDSC2 3.5867 8.0763 1.1616 12.791
CP50-MEL-B GDSC1; GDSC2 3.6728 7.9093 1.3137 11.6395
UACC-62 GDSC1; GDSC2 3.7339 8.3746 1.1302 12.5697
MMAc-SF GDSC1; GDSC2 3.9545 6.9166 2.0207 6.5666
VMRC-MELG GDSC1; GDSC2 4.032 6.7627 2.1514 5.5817
MZ-MEL-2 GDSC1; GDSC2 4.0527 8.9882 1.0724 12.0627
LB373-MEL-D GDSC1; GDSC2 4.246 6.7124 2.3211 4.0991
SK-MEL-1 GDSC1; GDSC2 4.2622 5.8168 2.7435 1.6678
CP66-MEL GDSC1; GDSC2 4.4713 9.6302 1.0668 11.0571
SK-MEL-24 GDSC1; GDSC2 4.6661 12.0401 0.0261 16.1311
SK-MEL-3 GDSC1; GDSC2 4.786 9.2086 1.4912 7.8929
COLO 792 GDSC1; GDSC2 4.81 8.2887 1.9421 5.2279
UACC-257 GDSC1; GDSC2 5.0266 9.7065 1.4141 7.8404
SK-MEL-31 GDSC1; GDSC2 5.6082 15.6466 -1.0545 18.692
EquiPSC Line K2 GDSC1; GDSC2 3.0923 6.8089 1.3835 12.9037
⏷ Show the Full List of 57 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1; GDSC2 1.1541 5.4519 0.1625 26.9924
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYM-1 GDSC1; GDSC2 -0.343 2.9286 -0.5776 37.7858
EW-8 GDSC1; GDSC2 1.0321 2.7607 0.9508 23.3963
SK-UT-1 GDSC1; GDSC2 1.1483 3.8081 0.8012 23.659
Hs 633.T GDSC1; GDSC2 1.2429 3.6773 0.9469 22.4386
SW982 GDSC1; GDSC2 1.2905 4.6542 0.6389 23.914
STS-0421 GDSC1; GDSC2 1.4575 5.4909 0.4574 24.181
VA-ES-BJ GDSC1; GDSC2 1.4726 4.1521 1.0288 20.9702
G-402 GDSC1; GDSC2 1.8013 6.8812 0.1575 24.3499
G-401 GDSC1; GDSC2 1.822 5.6235 0.7665 21.0135
Rh30 GDSC1; GDSC2 1.8533 4.703 1.2081 18.3547
MFH-ino GDSC1; GDSC2 1.9704 5.9318 0.7709 20.4126
Rh41 GDSC1; GDSC2 2.2751 5.5879 1.2309 16.593
HT-1080 GDSC1; GDSC2 2.3475 5.5222 1.3324 15.7201
MES-SA GDSC1; GDSC2 2.593 6.0232 1.3244 14.8972
SW872 GDSC1; GDSC2 2.6641 4.9987 1.8876 11.1925
SK-LMS-1 GDSC1; GDSC2 3.3676 6.0075 2.017 8.1271
A-204 GDSC1; GDSC2 3.3813 8.1651 0.9496 14.631
RKN GDSC1; GDSC2 3.7473 6.6656 1.99 7.2688
TE 441.T GDSC2 4.0542 8.341 1.3934 10.1584
RD GDSC1; GDSC2 4.1566 6.7651 2.2365 4.7901
Rh18 GDSC1 4.2368 10.1989 0.6129 17.026
SW684 GDSC1; GDSC2 4.2627 8.2425 1.5948 8.4409
GCT GDSC1; GDSC2 4.4663 10.2008 0.7833 12.668
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-39 GDSC1; GDSC2 -0.069 2.0007 -0.1191 34.2745
TGBC11TKB GDSC1; GDSC2 0.4234 2.7901 0.2864 29.781
SNU-16 GDSC1; GDSC2 0.5379 4.2466 -0.011 30.676
SNU-5 GDSC1; GDSC2 0.6191 3.2582 0.3894 28.3018
HGC-27 GDSC1; GDSC2 0.7227 3.7888 0.3454 28.033
OCUM-1 GDSC1; GDSC2 0.9781 6.5673 -0.5113 30.8269
AGS GDSC1; GDSC2 1.1133 3.8138 0.7613 24.0337
Hs 746.T GDSC1; GDSC2 1.2566 5.567 0.218 26.2705
MKN45 GDSC1; GDSC2 1.3008 4.8408 0.5736 24.2226
23132/87 GDSC1; GDSC2 1.3392 5.9181 0.1465 26.2773
NCI-N87 GDSC1; GDSC2 1.6919 6.4502 0.2543 24.288
SCH GDSC1; GDSC2 1.7241 5.4794 0.7336 21.587
NUGC-3 GDSC1; GDSC2 1.7472 5.6261 0.6903 21.7355
Fu97 GDSC1; GDSC2 1.7655 7.9338 -0.3819 27.0304
MKN1 GDSC1; GDSC2 1.8189 5.512 0.8144 20.756
SNU-1 GDSC1; GDSC2 2.2687 5.8109 1.1189 17.2819
SK-GT-2 GDSC1; GDSC2 2.5813 5.502 1.5665 13.4604
NUGC-4 GDSC1; GDSC2 3.0106 6.0742 1.6784 11.3343
MKN7 GDSC1; GDSC2 3.4064 7.2803 1.4127 11.786
KATO III GDSC1; GDSC2 3.5507 6.8678 1.7358 9.379
RF-48 GDSC1; GDSC2 3.5856 7.2421 1.577 10.2696
ECC10 GDSC1; GDSC2 3.7511 7.7462 1.4565 10.5609
TMK-1 GDSC1; GDSC2 3.7706 6.0784 2.2974 5.2927
ECC12 GDSC2 3.9579 7.636 1.6692 8.7246
MKN28 GDSC1; GDSC2 3.9797 8.3252 1.3451 10.6376
GCIY GDSC2 4.2925 8.2804 1.5976 8.3543
RERF-GC-1B GDSC1; GDSC2 4.3643 8.7445 1.4226 9.2326
IM95 GDSC1; GDSC2 4.432 7.6349 2.0057 5.5979
SNG-M GDSC1; GDSC2 0.2182 2.9881 0.0197 32.1266
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-62 GDSC1; GDSC2 0.4115 3.1146 0.1998 30.2744
HTC-C3 GDSC1; GDSC2 0.8123 4.0622 0.3504 27.5865
FTC-133 GDSC1; GDSC2 1.5366 6.5005 0.0777 25.799
KMH-2 GDSC1; GDSC2 1.5504 4.8063 0.8493 21.6488
IHH-4 GDSC1; GDSC2 1.7668 5.533 0.7524 21.3112
B-CPAP GDSC1; GDSC2 2.4336 5.5832 1.3865 15.0817
K5 GDSC1; GDSC2 2.4512 5.1789 1.5958 13.7464
BHT-101 GDSC1; GDSC2 2.5899 6.0308 1.3178 14.9479
ML-1 [Human leukemia] GDSC1; GDSC2 3.0328 7.3195 1.0774 14.938
8305C GDSC1; GDSC2 3.1576 11.6278 -0.9687 24.7176
8505C GDSC1; GDSC2 3.634 6.288 2.0902 6.9347
CGTH-W-1 GDSC1; GDSC2 3.673 6.0673 2.2297 5.9584
ASH-3 GDSC1; GDSC2 3.8406 6.8254 1.9814 7.0874
WRO GDSC1; GDSC2 3.9328 6.9225 2.0019 6.7345
TT GDSC1; GDSC2 5.1469 11.7595 0.5103 12.5493
TT2609-C02 GDSC1; GDSC2 5.7804 12.6267 0.5244 11.1357
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 41 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PCI-06A GDSC1; GDSC2 -1.0009 2.5444 -1.2084 43.9712
KON GDSC1; GDSC2 -0.7381 1.7504 -0.7993 40.9925
JHU-011 GDSC1; GDSC2 0.304 2.9966 0.1112 31.2479
HO-1-u-1 GDSC1; GDSC2 0.3343 2.4187 0.2563 30.3745
BB49-HNC GDSC1; GDSC2 0.6564 5.1115 -0.2153 31.0404
Ca9-22 GDSC1; GDSC2 0.6584 3.7653 0.283 28.6562
PCI-38 GDSC1 0.7231 3.1171 0.539 33.589
HSC-4 GDSC1; GDSC2 0.9672 5.1558 0.0933 28.1631
Detroit 562 GDSC1; GDSC2 0.9853 4.1063 0.5216 25.8975
BICR 10 GDSC1; GDSC2 1.0046 4.0777 0.5526 25.6457
BB30-HNC GDSC1; GDSC2 1.0513 4.7571 0.3447 26.5241
BICR 22 GDSC1; GDSC2 1.1362 5.2369 0.2358 26.7038
SAS GDSC1; GDSC2 1.5071 3.6642 1.2384 19.6496
PCI-15A GDSC1; GDSC2 1.5712 4.8255 0.8628 21.4867
OSC-19 GDSC1; GDSC2 1.5969 4.7249 0.932 20.9895
JHU-022 GDSC1; GDSC2 1.6925 5.2724 0.7941 21.375
CAL-33 GDSC1; GDSC2 1.8838 4.0733 1.4983 16.55
NCI-H3118 GDSC1; GDSC2 1.9759 4.7621 1.3091 17.2742
HSC-3 GDSC1; GDSC2 2.0395 5.3223 1.1222 18.1224
BICR 78 GDSC1; GDSC2 2.1831 6.8371 0.5439 20.8792
KOSC-2 GDSC1; GDSC2 2.2277 5.105 1.41 15.6992
PCI-30 GDSC1; GDSC2 2.3941 5.8287 1.2308 16.1614
HO-1-N-1 GDSC1; GDSC2 2.409 4.8873 1.6909 13.3249
SKN-3 GDSC1; GDSC2 2.5094 5.9934 1.2606 15.5735
JHU-029 GDSC1; GDSC2 2.5347 8.4042 0.0982 21.9714
CAL-27 GDSC1; GDSC2 2.7467 8.4741 0.2521 20.4726
LB771-HNC GDSC1; GDSC2 2.8281 7.0624 1.0258 15.8989
SCC-15 GDSC1; GDSC2 2.9689 7.9881 0.6885 17.3903
PCI-04B GDSC1; GDSC2 2.9935 7.878 0.7647 16.8811
HSC-2 GDSC1; GDSC2 3.1244 6.6972 1.467 12.2912
FaDu GDSC1; GDSC2 3.1751 6.0943 1.8115 9.9904
BICR 31 GDSC2 3.2371 11.0402 -0.6081 22.9898
SAT [Human HNSCC] GDSC1; GDSC2 3.246 9.2101 0.3143 18.5609
DOK GDSC1; GDSC2 3.2821 6.8051 1.5471 11.3207
OSC-20 GDSC1; GDSC2 3.6693 6.065 2.228 5.9786
SCC-4 GDSC1; GDSC2 3.8105 7.8035 1.4742 10.2956
BHY GDSC1; GDSC2 3.8266 7.716 1.53 9.9126
SCC-9 GDSC1; GDSC2 3.8493 9.698 0.562 15.4867
UPCI-SCC-090 GDSC1; GDSC2 4.1306 8.1183 1.5598 8.9666
SCC-25 GDSC1; GDSC2 4.7243 7.1721 2.4018 2.794
PE/CA-PJ15 GDSC1; GDSC2 5.0953 9.2679 1.6649 6.2779
⏷ Show the Full List of 41 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KU-19-19 GDSC1; GDSC2 0.1686 4.6566 -0.5579 34.8938
RT-112 GDSC1; GDSC2 0.7927 3.6969 0.4509 27.1585
CAL-29 GDSC1; GDSC2 0.8992 5.178 0.0129 28.8587
BFTC-905 GDSC2 1.0567 4.6396 0.3971 26.2286
TCCSUP GDSC1; GDSC2 1.6196 8.2902 -0.6924 28.9001
SW1710 GDSC1; GDSC2 2.8144 4.8442 2.1053 9.3175
647V GDSC1; GDSC2 2.8714 5.8471 1.6667 11.8557
HT-1197 GDSC1; GDSC2 2.9413 6.1013 1.6036 12.021
T24 GDSC1; GDSC2 3.0089 4.4502 2.4796 6.3192
5637 GDSC1; GDSC2 3.0455 5.6417 1.9243 9.6838
HT-1376 GDSC1; GDSC2 3.052 8.5774 0.466 18.3541
UM-UC-3 GDSC1; GDSC2 3.4223 6.5209 1.8053 9.3032
SW780 GDSC1; GDSC2 3.5959 8.4601 0.9775 13.8496
J82 GDSC1; GDSC2 3.8342 6.0241 2.3703 4.6888
RT-4 GDSC1; GDSC2 4.1794 9.1017 1.1118 11.5108
639V GDSC1; GDSC2 4.6135 11.9876 0.0127 16.3267
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
C-33 A GDSC1; GDSC2 0.2329 3.5633 -0.1181 32.6997
JAR GDSC1; GDSC2 0.3684 3.1696 0.139 30.7893
UWB1.289 GDSC1; GDSC2 0.7833 4.3307 0.2227 28.3692
NEC8 GDSC1; GDSC2 0.8337 2.625 0.7601 25.346
PWR-1E GDSC1; GDSC2 0.9018 4.0423 0.4541 26.6353
SW954 GDSC1; GDSC2 0.926 3.8946 0.5311 26.1194
KGN GDSC1; GDSC2 0.9423 5.9318 -0.2644 29.9363
C-4-I GDSC1; GDSC2 1.2634 4.6243 0.6223 24.1216
TC-YIK GDSC1; GDSC2 1.3408 4.1517 0.8876 22.3302
NCC-IT GDSC2 1.3682 4.5825 0.7498 22.9729
HEY GDSC1; GDSC2 1.3902 3.5344 1.1522 20.6495
OV17R GDSC1; GDSC2 1.405 6.3613 0.0113 26.6631
CAL-39 GDSC1; GDSC2 1.5592 3.8478 1.2327 19.4509
NT2-D1 GDSC1; GDSC2 1.5761 5.0351 0.7785 21.9382
PEO1 GDSC1; GDSC2 1.8626 6.6059 0.3477 23.1352
OVCA433 GDSC1; GDSC2 2.0362 4.9878 1.2707 17.262
HT-3 GDSC1; GDSC2 2.0782 6.4084 0.6501 20.6819
Ca Ski GDSC1; GDSC2 2.1973 6.0056 0.9571 18.493
ME-180 GDSC1; GDSC2 2.4471 5.5323 1.4238 14.8073
JEG-3 GDSC1; GDSC2 2.4734 7.4652 0.5066 20.0471
HeLa GDSC1; GDSC2 2.5952 4.8337 1.8993 11.3684
SiSo GDSC1; GDSC2 2.6124 6.061 1.324 14.8328
ACC-OV7 GDSC1; GDSC2 2.7036 8.1696 0.3653 20.0228
PA-1 GDSC2 2.8943 8.2193 0.5084 18.6269
OVCA420 GDSC1; GDSC2 2.9846 7.4104 0.9902 15.6052
OVMIU GDSC1; GDSC2 3.189 8.1539 0.7943 16.1036
JHOS-3 GDSC1; GDSC2 3.1956 8.1853 0.7842 16.1411
OMC-1 [Human cervical carcinoma] GDSC1; GDSC2 3.2095 6.1425 1.8169 9.8523
BPH-1 GDSC1; GDSC2 3.2779 6.71 1.5911 11.0603
SW756 GDSC1; GDSC2 3.3686 7.7366 1.1533 13.466
DoTc2 4510 GDSC1; GDSC2 3.4923 6.4207 1.9121 8.4364
SKN GDSC1; GDSC2 3.5172 8.8823 0.7027 15.6454
HEC-1 GDSC1; GDSC2 3.5719 6.8993 1.7371 9.3128
DSH1 GDSC1; GDSC2 3.7177 6.7553 1.9229 7.7644
SKG-IIIa GDSC1; GDSC2 3.7892 8.3441 1.1888 12.0717
SiHa GDSC1; GDSC2 3.84 7.458 1.6682 9.0293
SW962 GDSC1; GDSC2 3.9478 8.8291 1.071 12.344
MS751 GDSC1; GDSC2 4.1329 8.2483 1.4976 9.3366
LB831-BLC GDSC1; GDSC2 4.322 8.4047 1.5581 8.5228
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

References

1 ClinicalTrials.gov (NCT03428607) Study of AZD6738 and Olaparib Combination Therapy in Relapsed Small Cell Lung Cancer Patients [SUKSES-N2]. U.S. National Institutes of Health.
2 ClinicalTrials.gov (NCT01955668) AZD6738 First Time in Patient Multiple Ascending Dose Study. U.S. National Institutes of Health.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 National Cancer Institute Drug Dictionary (drug id 754022).