Details of the Drug

General Information of Drug (ID: DM0PVD9)

Drug Name
AZD1332
Synonyms AZD 1332; AZD-1332
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 391.8
Logarithm of the Partition Coefficient (xlogp) 3.7
Rotatable Bond Count (rotbonds) 7
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 8
Chemical Identifiers
Formula
C17H19ClFN7O
IUPAC Name
5-chloro-2-N-[1-(5-fluoropyridin-2-yl)ethyl]-4-N-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrimidine-2,4-diamine
Canonical SMILES
CC(C)OC1=NNC(=C1)NC2=NC(=NC=C2Cl)NC(C)C3=NC=C(C=C3)F
InChI
InChI=1S/C17H19ClFN7O/c1-9(2)27-15-6-14(25-26-15)23-16-12(18)8-21-17(24-16)22-10(3)13-5-4-11(19)7-20-13/h4-10H,1-3H3,(H3,21,22,23,24,25,26)
InChIKey
LBVKEEFIPBQIMD-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
49831044
TTD ID
D0MH1X

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
BDNF/NT-3 growth factors receptor (TrkB) TTKN7QR NTRK2_HUMAN Inhibitor [2]
NT-3 growth factor receptor (TrkC) TTXABCW NTRK3_HUMAN Inhibitor [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [4]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
NT-3 growth factor receptor (TrkC) DTT NTRK3 7.06E-04 -0.14 -0.43
BDNF/NT-3 growth factors receptor (TrkB) DTT NTRK2 3.06E-01 -0.15 -0.31
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 38 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 3.3796 7.3261 1.3677 14.9533
G-292 clone A141B1 GDSC1; GDSC2 -0.6636 4.5644 -1.4207 42.2345
NY GDSC1; GDSC2 0.4808 2.9774 0.3082 29.3884
H-EMC-SS GDSC1; GDSC2 0.719 4.9854 -0.0984 30.216
CAL-78 GDSC1; GDSC2 0.7238 3.6498 0.3907 27.7954
CHSA0011 GDSC1 0.831 5.4235 -0.1609 36.2565
CHSA0108 GDSC1 1.1482 6.8957 -0.4909 35.6472
CAL-72 GDSC1; GDSC2 2.0787 7.8834 -0.0628 24.3822
ES1 GDSC1 2.361 5.3718 1.4167 18.8103
CHSA8926 GDSC1; GDSC2 2.4186 5.7021 1.3151 15.5666
SaOS-2 GDSC1; GDSC2 2.6561 6.7337 1.0337 16.4234
ES8 GDSC1; GDSC2 2.7244 5.8733 1.5195 13.256
ES5 GDSC1; GDSC2 2.7858 6.388 1.322 14.2602
EW-11 GDSC1; GDSC2 2.8702 9.9209 -0.3612 23.0477
HuO9 GDSC1; GDSC2 2.895 7.152 1.0404 15.5953
SK-ES-1 GDSC1; GDSC2 2.9004 4.9793 2.1202 8.9298
EW-1 GDSC1; GDSC2 2.9307 5.6114 1.8367 10.6015
EW-3 GDSC1; GDSC2 3.025 6.3519 1.553 12.0688
NOS-1 [Human HNSCC] GDSC1; GDSC2 3.0568 6.6778 1.4182 12.801
MG-63 GDSC1; GDSC2 3.1135 8.7448 0.4349 18.3293
A-673 GDSC1; GDSC2 3.1846 7.127 1.3038 13.1075
EW-7 GDSC1; GDSC2 3.2541 5.416 2.2179 7.1896
EW-22 GDSC1; GDSC2 3.2575 7.756 1.051 14.4041
EW-18 GDSC1; GDSC2 3.2751 5.4807 2.2033 7.2193
ES7 GDSC1; GDSC2 3.3658 6.1688 1.9349 8.6504
SJSA-1 GDSC1 3.4999 8.2057 1.0267 16.8856
ES6 GDSC1; GDSC2 3.5246 8.3711 0.9642 14.1298
SK-PN-DW GDSC1; GDSC2 3.5793 7.3281 1.5291 10.5823
MHH-ES-1 GDSC1; GDSC2 3.6538 9.4272 0.5413 16.1454
TC-71 GDSC1; GDSC2 3.6693 8.4951 1.0188 13.4027
EW-24 GDSC1; GDSC2 3.7188 6.7195 1.9415 7.6452
ES4 GDSC1; GDSC2 3.765 5.6134 2.5212 3.9176
HuO-3N1 GDSC1; GDSC2 3.7992 8.8437 0.9481 13.4559
EW-16 GDSC2 3.8008 9.1 0.8217 14.1754
HOS GDSC1; GDSC2 3.8038 10.4332 0.1595 17.7307
EW-13 GDSC1; GDSC2 4.092 6.8551 2.1487 5.4635
U2OS GDSC1; GDSC2 4.5087 12.6949 -0.416 18.6041
CADO-ES1 GDSC1; GDSC2 4.9144 6.7232 2.6939 1.1149
⏷ Show the Full List of 38 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 160 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 3.2676 4.862 2.5062 6.6324
MOLM-13 GDSC1; GDSC2 -4.6648 -0.9525 -4.6945 75.7179
MV4-11 GDSC1; GDSC2 -4.488 -1.3176 -4.5008 75.5045
Mono-Mac-6 GDSC1 -3.1354 2.1223 -3.4376 70.046
CTV-1 GDSC1; GDSC2 -1.0456 0.4368 -1.0476 43.8368
WSU-DLCL2 GDSC1 -0.6428 2.682 -0.8485 49.6175
NKM-1 GDSC1 0.1722 4.4182 -0.4668 41.8069
KG-1 GDSC1; GDSC2 1.0153 8.1684 -1.2163 33.2581
SR GDSC1; GDSC2 1.2159 3.7721 0.8865 22.89
ALL-PO GDSC1; GDSC2 1.3584 4.4098 0.808 22.6938
SUP-M2 GDSC1; GDSC2 1.3616 3.407 1.1588 20.7435
DEL GDSC1; GDSC2 1.4963 3.8794 1.1536 20.1694
OPM-2 GDSC1; GDSC2 1.6035 3.3677 1.4339 18.1399
A4/Fukuda GDSC1; GDSC2 1.627 4.1598 1.191 19.3935
Karpas-299 GDSC1 1.6706 4.2686 1.1953 23.8403
SU-DHL-16 GDSC1 1.7392 3.3591 1.5843 20.8015
JVM-2 GDSC1; GDSC2 1.9394 5.1038 1.1205 18.5218
OCI-Ly7 GDSC1 1.9717 3.0914 1.9043 17.3127
HAL-01 GDSC1; GDSC2 1.9867 7.2537 0.1564 23.6465
OCI-M1 GDSC1; GDSC2 2.2241 3.8352 1.9529 12.5029
RL GDSC1 2.2243 4.9027 1.4992 18.8633
SCC-3 GDSC2 2.2579 3.9165 1.9576 12.3332
JeKo-1 GDSC1 2.2936 4.0087 1.9588 15.1677
SU-DHL-6 GDSC1; GDSC2 2.2968 3.2673 2.2176 10.7026
Loucy GDSC1; GDSC2 2.3376 3.4729 2.203 10.5972
ATN-1 GDSC1; GDSC2 2.3597 5.8838 1.1714 16.6396
RPMI-8866 GDSC1; GDSC2 2.3774 4.2266 1.9554 11.8585
Kasumi-1 GDSC1; GDSC2 2.4166 5.5381 1.3917 15.1114
RPMI-8402 GDSC1 2.5132 4.8859 1.7943 15.319
CRO-AP2 GDSC1 2.5459 4.4587 2.0245 13.4373
KMS-11 GDSC1 2.5459 6.6822 0.9581 21.1556
OCI-AML-5 GDSC1; GDSC2 2.5525 4.5287 1.9991 10.9179
BE-13 GDSC1; GDSC2 2.608 4.1974 2.2051 9.4639
P32/ISH GDSC1; GDSC2 2.6337 4.0955 2.2765 8.9367
RPMI-6666 GDSC1; GDSC2 2.7064 6.0332 1.4244 13.9006
A3/Kawakami GDSC1; GDSC2 2.738 4.3942 2.2456 8.7267
RCH-ACV GDSC1 2.7474 4.2172 2.3369 10.1345
L-1236 GDSC1; GDSC2 2.7764 5.2206 1.8869 10.8045
SU-DHL-4 GDSC1 2.8025 3.7433 2.6027 7.8856
GDM-1 GDSC1; GDSC2 2.8322 6.5256 1.2957 14.2678
WSU-NHL GDSC1; GDSC2 2.856 4.6486 2.2392 8.3421
L-540 GDSC1; GDSC2 2.8853 5.7211 1.7415 11.3443
BC-1 GDSC1; GDSC2 2.8933 4.7408 2.2299 8.2702
JVM-3 GDSC1; GDSC2 2.9461 5.0405 2.1324 8.6997
MC116 GDSC1 2.9552 4.0345 2.6277 6.9661
NB4 GDSC1 2.9657 4.8483 2.2447 9.8788
697 GDSC1; GDSC2 2.9872 5.0206 2.1797 8.2673
SUP-HD1 GDSC1; GDSC2 2.988 4.9972 2.1919 8.1882
P30/OHK GDSC1; GDSC2 3.0212 5.1908 2.1264 8.4909
GA-10 GDSC1; GDSC2 3.0274 5.3634 2.0465 8.9734
DoHH2 GDSC2 3.0669 4.1448 2.6825 4.8561
MOLP-8 GDSC1; GDSC2 3.0789 5.7448 1.9025 9.7153
NALM-6 GDSC1; GDSC2 3.1172 5.0399 2.2868 7.1742
ALL-SIL GDSC1; GDSC2 3.1186 4.8878 2.3637 6.6854
EoL-1 GDSC1; GDSC2 3.1207 4.7231 2.4473 6.1515
NCI-H929 GDSC1; GDSC2 3.1257 4.8378 2.3948 6.4668
MEG-01 GDSC1; GDSC2 3.1989 5.8378 1.9601 8.9837
DG-75 GDSC1; GDSC2 3.2063 6.2981 1.7364 10.3672
Ku812 GDSC1; GDSC2 3.2257 5.0102 2.3963 6.1466
SU-DHL-5 GDSC1; GDSC2 3.2263 4.8385 2.4825 5.5992
U-698-M GDSC1; GDSC2 3.2537 4.7804 2.5351 5.1839
Daudi GDSC1; GDSC2 3.2566 5.2695 2.2932 6.7056
CMK GDSC1 3.2799 5.2831 2.3061 8.1633
Jiyoye GDSC1; GDSC2 3.3108 5.2707 2.3382 6.2608
MLMA GDSC1; GDSC2 3.3139 6.9016 1.5254 11.361
ST486 GDSC1; GDSC2 3.3381 5.3973 2.2977 6.4377
CML-T1 GDSC1; GDSC2 3.344 4.7945 2.604 4.482
MOLT-13 GDSC1; GDSC2 3.3756 5.392 2.3312 6.1181
Raji GDSC1; GDSC2 3.403 4.965 2.567 4.5494
CA46 GDSC1; GDSC2 3.4078 5.8412 2.1331 7.2794
SUP-T1 GDSC1; GDSC2 3.4133 4.7126 2.7012 3.6721
OCI-Ly19 GDSC1 3.4302 5.9465 2.0987 9.2498
OCI-AML-2 GDSC1; GDSC2 3.4415 5.094 2.5335 4.6547
BV-173 GDSC1; GDSC2 3.4433 5.0636 2.5501 4.5454
JURL-MK1 GDSC1; GDSC2 3.4464 5.2974 2.4359 5.2586
MOLM-16 GDSC1 3.4551 6.0328 2.0758 9.3414
EM-2 GDSC1; GDSC2 3.4679 4.8635 2.6691 3.7278
Karpas-1106P GDSC1; GDSC2 3.4704 4.9572 2.6245 4.0028
VAL GDSC1; GDSC2 3.4792 6.6634 1.7804 9.2988
KCL-22 GDSC1; GDSC2 3.495 5.3505 2.448 5.0498
CESS GDSC1; GDSC2 3.4997 4.9301 2.6608 3.6971
PL-21 GDSC1 3.5234 6.7182 1.7886 11.318
TUR GDSC1; GDSC2 3.5465 6.0628 2.1339 6.8926
YT GDSC1 3.5642 5.5327 2.4114 6.349
KOPN-8 GDSC1; GDSC2 3.5684 5.2831 2.5385 4.2884
RS4;11 GDSC1; GDSC2 3.5989 5.7039 2.3532 5.3739
SKM-1 GDSC1; GDSC2 3.6233 7.8931 1.2824 11.9647
NU-DUL-1 GDSC1 3.6521 5.2863 2.5995 4.6075
L-363 GDSC1; GDSC2 3.6527 4.8839 2.7965 2.4796
Jurkat GDSC1; GDSC2 3.6669 6.4033 2.0585 7.0478
Reh GDSC1; GDSC2 3.6736 5.4032 2.5578 3.9067
DND-41 GDSC1; GDSC2 3.6792 5.294 2.6154 3.5353
ML-2 GDSC1; GDSC2 3.6858 5.9064 2.319 5.3673
BL-41 GDSC1; GDSC2 3.7 5.7074 2.4277 4.6528
LAMA-84 GDSC1; GDSC2 3.7023 6.1516 2.2102 6.0062
Sc-1 GDSC1 3.7347 6.3451 2.1391 7.924
Karpas-45 GDSC1; GDSC2 3.7385 5.4025 2.6051 3.4613
MOLT-16 GDSC1; GDSC2 3.7436 5.0803 2.7645 2.4754
MHH-PREB-1 GDSC1; GDSC2 3.7502 5.6213 2.5067 4.0415
RPMI-8226 GDSC1; GDSC2 3.7525 7.259 1.6997 9.0615
WIL2 NS GDSC1; GDSC2 3.7583 5.6812 2.4833 4.1677
VL51 GDSC1; GDSC2 3.7657 6.8811 1.8973 7.8005
EJM GDSC1; GDSC2 3.7848 5.4725 2.6037 3.3649
Karpas-620 GDSC1; GDSC2 3.7948 7.3712 1.6766 9.0941
AMO1 GDSC1; GDSC2 3.8126 5.5239 2.5981 3.3374
MHH-CALL-2 GDSC1; GDSC2 3.8133 5.2786 2.7166 2.6173
HEL GDSC1; GDSC2 3.8211 5.8108 2.4649 4.1354
Namalwa GDSC1; GDSC2 3.8348 6.5951 2.0907 6.4224
JJN-3 GDSC1; GDSC2 3.837 6.0189 2.3749 4.6539
BALL-1 GDSC1; GDSC2 3.8441 5.3617 2.6975 2.6684
SUP-B8 GDSC1 3.8509 5.9674 2.41 5.486
K-562 GDSC1; GDSC2 3.8584 7.3966 1.7126 8.7083
EHEB GDSC1 3.8703 6.932 1.951 8.9433
P31/FUJ GDSC1 3.9159 5.5005 2.679 3.28
PF-382 GDSC1; GDSC2 3.9438 5.8041 2.553 3.3294
ARH-77 GDSC1; GDSC2 3.9471 7.1323 1.9093 7.2726
QIMR-WIL GDSC1 3.9515 7.033 1.9614 8.6171
MN-60 GDSC1; GDSC2 4.0833 6.2148 2.4502 3.6582
EB2 GDSC1; GDSC2 4.1186 6.3401 2.4139 3.8031
LC4-1 GDSC1; GDSC2 4.1243 6.1324 2.5159 3.1876
HT GDSC1 4.1276 5.7991 2.673 2.831
KE-37 GDSC1; GDSC2 4.1641 5.9328 2.6337 2.4317
SU-DHL-10 GDSC1; GDSC2 4.1773 5.7973 2.7035 2.0173
MOLT-4 GDSC1; GDSC2 4.2103 6.2552 2.513 3.0418
H9 GDSC1; GDSC2 4.221 9.1709 1.1087 11.425
KMS-12-BM GDSC2 4.2285 6.0668 2.6112 2.4472
JSC-1 GDSC1; GDSC2 4.2351 6.6231 2.3562 3.9129
Karpas-422 GDSC1; GDSC2 4.24 6.5066 2.4142 3.5615
CTB-1 GDSC1 4.2749 8.119 1.6638 9.8726
NOMO-1 GDSC1; GDSC2 4.2849 7.916 1.7695 7.3351
IM-9 GDSC1; GDSC2 4.2926 6.1774 2.5991 2.4061
P12-Ichikawa GDSC1; GDSC2 4.3044 5.8018 2.7734 1.4521
KMOE-2 GDSC1; GDSC2 4.3125 6.2996 2.5553 2.6181
Hs 445 GDSC1; GDSC2 4.3169 7.5883 1.9502 6.1736
Farage GDSC1; GDSC2 4.3404 6.5979 2.4349 3.2538
Ramos.2G6.4C10 GDSC1; GDSC2 4.3618 6.7243 2.3895 3.476
HC-1 GDSC1; GDSC2 4.3752 9.32 1.1489 10.8138
OCI-AML-3 GDSC1; GDSC2 4.4155 6.3294 2.6021 2.1915
GR-ST GDSC1; GDSC2 4.4159 7.2337 2.1853 4.5659
HDLM-2 GDSC1; GDSC2 4.4159 6.5446 2.5052 2.7235
Karpas-231 GDSC1; GDSC2 4.4315 5.907 2.7951 1.1812
ME1 GDSC1; GDSC2 4.44 6.4723 2.5521 2.4248
DB GDSC1; GDSC2 4.4514 6.93 2.3498 3.5419
HL-60 GDSC1; GDSC2 4.5147 5.595 2.9599 0.4178
CCRF-CEM GDSC1; GDSC2 4.5728 6.2926 2.704 1.447
KY821 GDSC1; GDSC2 4.6486 6.8377 2.5078 2.3426
HH [Human lymphoma] GDSC1; GDSC2 4.6764 7.3172 2.3084 3.3842
THP-1 GDSC1 4.7227 6.637 2.6349 1.9884
U266B1 GDSC1; GDSC2 4.8767 7.2549 2.4501 2.3168
SK-MM-2 GDSC1; GDSC2 4.8958 6.7749 2.6638 1.2646
RC-K8 GDSC1; GDSC2 4.9276 6.6067 2.7469 0.8849
TK [Human B-cell lymphoma] GDSC1; GDSC2 4.9651 6.9837 2.6114 1.4252
SU-DHL-8 GDSC1; GDSC2 5.0833 6.6284 2.8064 0.5541
Granta-519 GDSC1; GDSC2 5.131 7.2361 2.588 1.3549
KM-H2 GDSC1; GDSC2 5.1771 7.6424 2.4417 1.9714
MM1.S GDSC2 5.2652 6.8086 2.8133 0.4298
SUP-B15 GDSC2 5.4472 7.4332 2.6534 0.8252
ROS-50 GDSC1 5.5286 7.5157 2.6565 0.9445
L-428 GDSC1; GDSC2 5.8682 7.2952 2.8653 0.128
LP-1 GDSC1; GDSC2 5.9856 7.6154 2.7976 0.2025
⏷ Show the Full List of 160 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCE-4 GDSC1 1.9379 3.5904 1.7305 18.6846
FLO-1 GDSC1; GDSC2 2.1146 5.268 1.2221 17.2469
TE-12 GDSC1; GDSC2 2.8261 5.5589 1.7674 11.3795
KYSE-220 GDSC1; GDSC2 3.1395 6.3034 1.6766 10.9442
KYSE-50 GDSC1; GDSC2 3.3678 5.0399 2.5009 5.0666
SK-GT-4 GDSC1; GDSC2 3.3969 6.1769 1.9565 8.4252
OACP4 C GDSC1; GDSC2 3.427 6.2808 1.9291 8.5126
OACM5.1 C GDSC1; GDSC2 3.4845 5.5999 2.3154 5.9153
KYAE-1 GDSC1; GDSC2 4.7625 6.5716 2.6826 1.3244
ESO-51 GDSC1; GDSC2 5.0758 12.3612 0.1675 14.457
ESO-26 GDSC1; GDSC2 5.5934 7.2379 2.7854 0.3526
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1; GDSC2 4.4851 9.0615 1.3543 9.3562
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SJNB-12 GDSC1 1.0947 6.3739 -0.3062 35.2535
NB1 GDSC1 1.4576 3.3074 1.2913 24.3871
NB69 GDSC1; GDSC2 1.4716 3.2469 1.3226 19.3499
CHP-212 GDSC1; GDSC2 1.59 4.3008 1.097 20.0836
SK-N-SH GDSC1 2.0304 4.8915 1.3078 21.1852
GI-ME-N GDSC1; GDSC2 2.2646 7.8536 0.1242 22.7879
SJNB-5 GDSC1 2.3828 6.5437 0.8742 22.4362
TGW GDSC1; GDSC2 2.4318 4.554 1.8663 12.1784
SJNB-17 GDSC1 2.6822 5.3956 1.7134 15.1703
SK-N-FI GDSC1 2.8345 5.8739 1.62 15.2236
SJNB-14 GDSC1; GDSC2 2.8858 5.4055 1.8976 10.3686
CHP-126 GDSC1 2.9937 5.1093 2.1419 10.5631
SJNB-6 GDSC1 3.0524 6.8435 1.3318 16.4565
KP-N-YN GDSC1; GDSC2 3.0575 7.9084 0.8048 16.4511
NH-12 GDSC1; GDSC2 3.2297 6.336 1.7373 10.2911
SJNB-13 GDSC1; GDSC2 3.2383 5.6491 2.088 8.058
NB(TU)1 GDSC1; GDSC2 3.2642 5.487 2.191 7.3297
LA-N-6 GDSC1 3.3104 9.0403 0.4531 21.1786
SK-N-DZ GDSC1; GDSC2 3.3152 6.2522 1.8512 9.324
SK-N-MC-IXC GDSC1 3.3777 5.1966 2.4307 6.8292
SK-N-BE(2)-M17 GDSC1; GDSC2 3.3995 6.0915 2.0012 8.1359
IMR-5 GDSC1; GDSC2 3.4463 7.3725 1.3994 11.7526
SiMa GDSC1; GDSC2 3.4949 8.9111 0.6701 15.8921
GOTO GDSC1; GDSC2 3.5083 7.3374 1.4673 11.16
SJNB-7 GDSC1; GDSC2 3.5834 7.7445 1.3246 11.8208
SJNB-10 GDSC1; GDSC2 3.6038 5.6746 2.3714 5.2464
Kelly GDSC1; GDSC2 3.7428 7.7324 1.4569 10.5809
SK-N-AS GDSC1; GDSC2 3.9719 5.7816 2.5825 3.095
CHP-134 GDSC2 4.1798 6.6473 2.3083 4.3094
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1; GDSC2 3.6222 5.9212 2.2633 5.8785
Cancer Drug Sensitivity Data Curated from 49 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MFM-223 GDSC1; GDSC2 -1.1641 6.1474 -2.5562 46.8428
HCC1395 GDSC1 1.4491 3.9562 1.0754 25.8698
Hs 578T GDSC1; GDSC2 1.6727 5.7413 0.5631 22.7326
CAL-120 GDSC1; GDSC2 1.7218 5.1937 0.8589 20.8919
CAL-51 GDSC1; GDSC2 2.3335 6.4256 0.8852 18.4141
JIMT-1 GDSC1; GDSC2 2.8149 5.02 2.0206 9.8414
MDA-MB-468 GDSC1; GDSC2 3.0175 6.4957 1.4747 12.5768
MDA-MB-453 GDSC1; GDSC2 3.146 8.7003 0.4847 17.9592
DU4475 GDSC1; GDSC2 3.1663 5.1353 2.2825 7.0483
HCC1806 GDSC1; GDSC2 3.2229 5.2608 2.2688 6.9611
HCC1599 GDSC1 3.2292 8.4611 0.6747 20.16
HCC202 GDSC1 3.4782 6.4796 1.8713 10.8433
HCC1187 GDSC1; GDSC2 3.4993 7.67 1.2939 12.2432
MDA-MB-231 GDSC1; GDSC2 3.5166 7.185 1.5501 10.6267
MCF-7 GDSC1; GDSC2 3.5178 7.3337 1.4768 11.0749
MDA-MB-157 GDSC1; GDSC2 3.5414 8.5002 0.9134 14.3765
MDA-MB-361 GDSC1; GDSC2 3.5863 6.8141 1.791 8.9374
Evsa-T GDSC1; GDSC2 3.6673 8.4608 1.0344 13.3171
HDQ-P1 GDSC1; GDSC2 3.6991 6.2245 2.1717 6.2558
MRK-nu-1 GDSC1; GDSC2 3.7134 5.8924 2.3466 5.1259
HCC1937 GDSC1; GDSC2 3.7543 6.2166 2.2173 5.8321
COLO 824 GDSC1; GDSC2 3.8501 6.0639 2.3623 4.7011
HCC1569 GDSC1; GDSC2 3.9242 7.6877 1.6184 9.1208
BT-549 GDSC1; GDSC2 4.0651 7.5061 1.8122 7.5862
EFM-192A GDSC1; GDSC2 4.1848 7.0341 2.1264 5.3949
HCC70 GDSC1; GDSC2 4.2447 7.9445 1.7272 7.683
HCC1143 GDSC1; GDSC2 4.3479 8.8333 1.3674 9.5983
HCC2157 GDSC1; GDSC2 4.3531 6.5726 2.4544 3.1188
HCC1419 GDSC1; GDSC2 4.3847 6.5383 2.4894 2.8649
HCC38 GDSC1; GDSC2 4.3903 11.1477 0.2598 15.6526
EFM-19 GDSC1; GDSC2 4.4977 11.8413 -0.002 16.689
CAL-85-1 GDSC1; GDSC2 4.5955 7.8349 2.0181 5.1965
MDA-MB-415 GDSC1; GDSC2 4.5967 15.6926 -1.8358 23.936
HCC1428 GDSC1; GDSC2 4.692 6.5187 2.6693 1.4686
MDA-MB-175-VII GDSC1 4.8038 6.6357 2.6763 1.6281
HCC1500 GDSC1; GDSC2 4.8039 6.843 2.5891 1.7177
T-47D GDSC1; GDSC2 4.8057 12.3915 -0.0436 16.1285
BT-474 GDSC1; GDSC2 4.8349 6.5362 2.7322 1.0298
HCC1954 GDSC1; GDSC2 4.906 7.0017 2.5743 1.6648
OCUB-M GDSC1; GDSC2 5.11 12.3535 0.1956 14.2382
MDA-MB-330 GDSC1; GDSC2 5.1384 9.4166 1.6227 6.4362
CAMA-1 GDSC1; GDSC2 5.2995 6.8706 2.8042 0.4379
MDA-MB-436 GDSC1; GDSC2 5.4237 9.4457 1.7837 5.0358
BT-20 GDSC1; GDSC2 5.4438 7.3806 2.6721 0.7628
AU565 GDSC1; GDSC2 5.4623 11.7854 0.7136 10.8035
BT-483 GDSC1 5.4674 22.7267 -4.6556 31.7207
HCC2218 GDSC1 5.9487 8.0101 2.6435 0.6922
ZR-75-30 GDSC1; GDSC2 6.118 7.8582 2.7614 0.2295
UACC-893 GDSC1 6.1849 8.1524 2.6832 0.4483
⏷ Show the Full List of 49 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-172 GDSC1; GDSC2 0.7901 6.158 -0.5199 31.708
KS-1 [Human Krukenberg tumour] GDSC1; GDSC2 1.0959 5.9982 -0.1366 28.6791
D-263MG GDSC1; GDSC2 1.2198 4.6402 0.5697 24.5954
MOG-G-CCM GDSC1 1.5629 4.8819 0.8303 26.8151
D-566MG GDSC1 1.5642 3.5949 1.3227 23.5657
SF126 GDSC1 1.7453 4.2212 1.2932 22.7675
CAS-1 GDSC1; GDSC2 1.774 6.9783 0.0849 24.8184
SF539 GDSC1; GDSC2 1.8051 5.4235 0.8407 20.6615
YH-13 GDSC1; GDSC2 1.8615 4.299 1.3853 17.2944
NMC-G1 GDSC1 1.9313 5.4314 0.9639 24.0213
Hs 683 GDSC1 1.9904 4.3672 1.4929 20.0797
MOG-G-UVW GDSC1 2.007 4.9953 1.2377 21.7917
D-336MG GDSC1 2.0358 4.8677 1.3239 21.0451
SW1783 GDSC1 2.2002 4.8268 1.5092 18.9083
D283 Med GDSC1; GDSC2 2.2372 9.3619 -0.6437 26.4122
LNZTA3WT4 GDSC1 2.2864 5.8043 1.1391 21.1159
42-MG-BA GDSC1; GDSC2 2.4777 5.2498 1.588 13.6983
D-247MG GDSC1 2.4833 6.9255 0.7811 22.5769
T98G GDSC1; GDSC2 2.49 6.596 0.9487 17.4926
SW1088 GDSC1; GDSC2 2.5196 7.0395 0.7584 18.4863
SNB-75 GDSC1 2.5279 6.6092 0.9773 21.1082
KNS-42 GDSC1 2.5438 4.6405 1.9389 14.0903
D-502MG GDSC1 2.5842 6.0416 1.3071 18.5864
DBTRG-05MG GDSC1; GDSC2 2.628 7.4442 0.6573 18.6853
H4 GDSC1; GDSC2 2.662 8.1947 0.3159 20.4225
GI-1 GDSC1; GDSC2 2.7067 10.8651 -0.9739 26.1529
D-542MG GDSC1 2.8806 5.6356 1.7794 13.8264
D-423MG GDSC1 2.8854 6.2327 1.4885 15.9898
DK-MG GDSC1; GDSC2 2.953 6.5159 1.408 13.1913
YKG-1 GDSC1 3.0158 5.3824 2.0266 11.3703
Onda 10 GDSC1 3.0317 6.887 1.2921 16.8222
M059J GDSC1; GDSC2 3.0447 6.6619 1.4157 12.8544
8-MG-BA GDSC1; GDSC2 3.2105 6.9329 1.4228 12.3014
GaMG GDSC1; GDSC2 3.2259 8.7655 0.5197 17.5233
KNS-81-FD GDSC1 3.2972 6.5473 1.6886 12.8873
SF295 GDSC1 3.4478 7.2382 1.4677 13.9812
Daoy GDSC1; GDSC2 3.4915 5.9285 2.1571 6.8952
LN-18 GDSC1; GDSC2 3.5269 6.1328 2.0834 7.2633
U-118MG GDSC1; GDSC2 3.6068 7.3107 1.5597 10.3177
SF268 GDSC1; GDSC2 3.6132 10.3818 0.0317 18.9126
GB-1 GDSC1; GDSC2 3.6388 7.2434 1.6186 9.8668
Onda 11 GDSC1 3.6466 7.2196 1.6366 12.04
D-392MG GDSC1; GDSC2 3.7047 8.8711 0.8596 14.2249
PFSK-1 GDSC1; GDSC2 3.7894 7.0298 1.8417 8.0855
Becker GDSC1; GDSC2 3.8231 6.5463 2.106 6.3558
ONS-76 GDSC1; GDSC2 3.8265 6.9929 1.8881 7.7028
KINGS-1 GDSC1; GDSC2 3.844 8.6171 1.0958 12.4742
KALS-1 GDSC1; GDSC2 3.8545 11.7334 -0.4486 20.4927
U-251MG GDSC1; GDSC2 3.8579 10.5679 0.1354 17.7017
SK-MG-1 GDSC1; GDSC2 3.8781 7.8455 1.5053 9.9297
LN-229 GDSC1; GDSC2 4.0327 7.4179 1.8319 7.5428
LN-405 GDSC1; GDSC2 4.1898 8.7737 1.2811 10.4907
U-87MG ATCC GDSC1; GDSC2 4.3652 11.8504 -0.1071 17.5363
AM-38 GDSC1; GDSC2 4.3715 6.5337 2.4836 2.9205
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC24TKB GDSC1; GDSC2 3.2386 6.2511 1.7873 9.9511
TGBC1TKB GDSC1 3.3805 5.83 2.1164 9.2877
ETK-1 GDSC1; GDSC2 4.4933 7.5639 2.0797 5.0352
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AN3-CA GDSC1; GDSC2 -0.0701 6.002 -1.3448 38.7082
MFE-280 GDSC1; GDSC2 0.9251 5.1114 0.0675 28.4789
ESS-1 GDSC1; GDSC2 1.003 5.1046 0.1521 27.713
MFE-296 GDSC1; GDSC2 3.4359 12.7295 -1.2872 25.1061
KLE GDSC1; GDSC2 3.8022 12.1823 -0.7146 21.7972
MFE-319 GDSC1; GDSC2 3.9567 6.491 2.2302 5.2694
RL95-2 GDSC1; GDSC2 3.9971 11.5194 -0.2286 19.0905
EN GDSC1; GDSC2 5.0986 10.5798 1.0456 9.7672
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-704 GDSC1; GDSC2 0.069 2.2607 -0.0047 33.0081
CAL-54 GDSC1; GDSC2 0.2982 3.2965 0.0289 31.6767
UO-31 GDSC1 0.4805 5.3834 -0.5114 39.7657
LB1047-RCC GDSC1 0.6139 3.1807 0.404 35.0647
KTCTL-26A GDSC1 0.8736 3.6306 0.5598 32.5011
LB2241-RCC GDSC1 1.0469 3.6603 0.7392 30.3648
NCC021 GDSC1 1.2143 3.9901 0.8101 28.9249
RXF 393L GDSC1; GDSC2 1.3008 5.7083 0.201 26.1675
LB996-RCC GDSC1; GDSC2 1.5872 5.5996 0.5409 23.1985
KTCTL-13 GDSC1 1.5897 4.4456 1.0391 25.3257
KTCTL-140 GDSC1 1.6037 4.2649 1.1255 24.6754
Caki-1 GDSC1 1.8041 3.988 1.4455 21.3969
KMRC-1 GDSC1 1.9592 3.6411 1.7368 18.5228
ACHN GDSC1; GDSC2 2.0559 6.9406 0.3733 22.2665
KTCTL-1M GDSC1 2.0681 4.3409 1.5851 19.0216
NCC010 GDSC1; GDSC2 2.6981 7.0603 0.9104 17.0054
BB65-RCC GDSC1 2.8285 7.4831 0.8171 20.863
786-O GDSC1; GDSC2 2.887 6.8088 1.204 14.6442
BFTC-909 GDSC1; GDSC2 3.0978 7.4236 1.0814 14.7114
HA7-RCC GDSC1; GDSC2 3.1251 5.7698 1.9304 9.3965
769-P GDSC1; GDSC2 3.1562 8.2167 0.7351 16.541
A-498 GDSC1; GDSC2 3.2946 5.9808 1.9697 8.638
RCC10RGB GDSC1; GDSC2 3.306 7.0297 1.4547 11.8206
SW156 GDSC1 3.3554 7.2431 1.3891 14.888
KTCTL-195 GDSC1; GDSC2 3.3555 6.3426 1.8395 9.2804
TK-10 GDSC1; GDSC2 3.4718 6.4063 1.9028 8.552
KTCTL-21 GDSC1 3.483 7.6872 1.2721 15.2587
SN12C GDSC1; GDSC2 3.5088 8.4694 0.9022 14.5347
OS-RC-2 GDSC1; GDSC2 3.7104 5.2685 2.6504 3.2467
VMRC-RCZ GDSC1; GDSC2 3.8463 8.597 1.1077 12.3983
SW13 GDSC1; GDSC2 4.5629 6.8867 2.4367 2.8603
KMRC-20 GDSC1; GDSC2 4.6932 10.6975 0.7051 12.5523
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 47 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H716 GDSC1; GDSC2 -3.1614 0.0505 -3.1957 63.9377
SW48 GDSC1; GDSC2 1.7921 5.2969 0.8845 20.4647
GP5d GDSC1; GDSC2 2.564 4.1377 2.1864 9.7472
HCT 116 GDSC1; GDSC2 2.9718 5.0851 2.1339 8.6055
CaR-1 GDSC1; GDSC2 3.0389 5.7103 1.8844 9.9549
LoVo GDSC1; GDSC2 3.1443 9.3998 0.1338 19.8042
C2BBe1 GDSC1; GDSC2 3.1535 4.7649 2.4557 5.9949
HCT 15 GDSC1; GDSC2 3.3304 6.6135 1.6832 10.332
LS123 GDSC1; GDSC2 3.3345 6.1937 1.8965 8.982
NCI-H747 GDSC1; GDSC2 3.3496 5.1271 2.4423 5.4892
SW620 GDSC1; GDSC2 3.4334 7.0093 1.5703 10.7369
SNU-407 GDSC1; GDSC2 3.452 5.9864 2.0965 7.3869
HT-29 GDSC1; GDSC2 3.509 5.7936 2.2383 6.3357
LS513 GDSC1; GDSC2 3.5685 4.9413 2.7074 3.2301
COLO205 GDSC1; GDSC2 3.605 4.8585 2.7749 2.7225
SNU-C5 GDSC1; GDSC2 3.6074 6.0721 2.1769 6.4595
LS180 GDSC1; GDSC2 3.6251 5.663 2.3935 5.0536
HCC2998 GDSC1; GDSC2 3.6565 8.694 0.9094 14.0736
HT-55 GDSC1; GDSC2 3.6726 8.0722 1.2323 12.1294
CL-11 GDSC1; GDSC2 3.682 7.5894 1.4803 10.6007
RKO GDSC1; GDSC2 3.7805 6.9145 1.892 7.7951
LS1034 GDSC1; GDSC2 3.819 7.0676 1.8455 7.9862
SNU-175 GDSC2 3.8466 7.5936 1.606 9.3946
MDST8 GDSC1; GDSC2 3.8875 10.225 0.3297 16.6217
SNU-81 GDSC1; GDSC2 4.0125 8.5292 1.269 11.0081
CCK-81 GDSC1; GDSC2 4.0667 7.0314 2.0453 6.1529
SK-CO-1 GDSC1; GDSC2 4.0696 9.8421 0.6621 14.3454
SW626 GDSC1; GDSC2 4.1191 10.0178 0.613 14.4846
SW1116 GDSC1; GDSC2 4.1263 8.444 1.3964 9.9608
SNU-C1 GDSC1; GDSC2 4.1424 6.6115 2.3005 4.4339
COLO 320HSR GDSC1; GDSC2 4.1486 6.4374 2.3875 3.8997
HT115 GDSC1; GDSC2 4.1516 8.1351 1.5669 8.8728
SW837 GDSC1; GDSC2 4.2031 6.9798 2.165 5.1225
SW948 GDSC1; GDSC2 4.2095 5.8547 2.6964 2.0038
SNU-1040 GDSC1; GDSC2 4.3172 6.0957 2.6504 2.0835
T84 GDSC1; GDSC2 4.4211 7.6709 1.9812 5.7661
SW1463 GDSC1; GDSC2 4.4433 13.3077 -0.77 20.3119
NCI-H508 GDSC1 4.4625 8.9066 1.4136 11.114
SNU-61 GDSC1; GDSC2 4.5045 6.8129 2.4358 2.962
SW1417 GDSC1; GDSC2 4.6109 11.4472 0.277 15.0121
LS411N GDSC1; GDSC2 4.7074 14.1117 -0.9663 20.4533
DiFi GDSC1; GDSC2 4.8127 7.0698 2.4961 2.17
SNU-C2B GDSC1; GDSC2 4.8745 10.9419 0.7155 12.0737
CW-2 GDSC1; GDSC2 4.9286 8.3473 1.9885 4.7467
RCM-1 [Human ESC] GDSC1; GDSC2 5.1487 9.6001 1.5433 6.8656
KM12 GDSC1; GDSC2 5.3672 7.5658 2.5655 1.223
COLO 678 GDSC1; GDSC2 6.1588 16.7073 -1.1792 17.9956
⏷ Show the Full List of 47 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1; GDSC2 5.3549 6.9929 2.7812 0.474
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Huh-7 GDSC1; GDSC2 0.9766 5.1916 0.0883 28.1449
Hep 3B2.1-7 GDSC1; GDSC2 1.4565 5.9073 0.27 25.1631
HLE GDSC1; GDSC2 1.7936 7.9693 -0.3724 26.881
JHH-4 GDSC1; GDSC2 1.9416 6.6247 0.4152 22.4762
SNU-449 GDSC1; GDSC2 2.2357 7.605 0.2193 22.4086
HuH-1 GDSC1; GDSC2 2.3042 6.2154 0.9591 18.091
JHH-2 GDSC1; GDSC2 3.0796 4.7405 2.4018 6.5704
JHH-6 GDSC1; GDSC2 3.2176 6.6005 1.5949 11.2159
SNU-423 GDSC1; GDSC2 3.3195 6.8517 1.555 11.1613
JHH-7 GDSC1; GDSC2 3.3551 7.6013 1.2099 13.1667
SNU-398 GDSC1; GDSC2 3.6419 10.0471 0.2222 17.869
SNU-387 GDSC1; GDSC2 3.6519 8.605 0.9501 13.8511
Hep-G2/C3A GDSC1; GDSC2 3.6763 6.5467 1.9945 7.424
JHH-1 GDSC1; GDSC2 3.739 6.7219 1.9558 7.5042
SK-HEP-1 GDSC1; GDSC2 4.4727 9.3486 1.2055 10.2541
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 177 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2795 GDSC1; GDSC2 -1.2898 3.2389 -1.6886 46.8909
NCI-H1581 GDSC1; GDSC2 -0.1319 6.7607 -1.7314 39.976
NCI-H2810 GDSC1; GDSC2 0.3396 3.5554 0.0006 31.6035
SBC-3 GDSC1; GDSC2 0.5029 5.7742 -0.6509 33.5734
NCI-H1341 GDSC1 0.6902 4.3376 0.1202 35.9619
NCI-H838 GDSC1 0.8032 3.7085 0.4587 33.5174
HCC78 GDSC1; GDSC2 0.9741 10.3566 -2.3027 36.4277
NCI-H1573 GDSC1 1.0419 10.169 -2.1478 40.4892
NCI-H847 GDSC1 1.06 3.922 0.6669 30.7182
LK-2 GDSC1; GDSC2 1.0642 6.437 -0.3655 29.8366
LC-2/ad GDSC1 1.144 4.682 0.4728 31.3191
NCI-H2030 GDSC1 1.1888 5.1406 0.3313 31.8116
NCI-H1648 GDSC1 1.2515 3.6056 0.979 27.639
NCI-H2731 GDSC1; GDSC2 1.3827 5.838 0.2266 25.6919
NCI-H292 GDSC1 1.4296 3.7033 1.1413 25.5454
NCI-H2228 GDSC1; GDSC2 1.4702 4.4923 0.8939 21.7367
NCI-H524 GDSC1; GDSC2 1.6459 4.8925 0.9119 20.9004
EMC-BAC-1 GDSC1 1.6816 4.4384 1.139 24.1604
NCI-H647 GDSC1 1.7927 4.6464 1.1693 23.3639
NCI-H2818 GDSC1; GDSC2 1.8389 6.8302 0.2181 23.8969
RERF-LC-MS GDSC1 1.9331 5.0893 1.1206 22.9681
HCC44 GDSC1; GDSC2 1.9565 5.2095 1.0902 18.6313
NCI-H2869 GDSC1; GDSC2 2.0059 6.1432 0.7061 20.6419
NCI-H446 GDSC1; GDSC2 2.053 8.2059 -0.2442 25.3286
NCI-H2085 GDSC1; GDSC2 2.0896 3.9478 1.7662 14.1433
CAL-12T GDSC1 2.1001 3.9616 1.772 17.5171
NCI-H290 GDSC1 2.1107 5.4178 1.1491 21.8891
NCI-H2009 GDSC1 2.112 5.6469 1.0435 22.598
A-549 GDSC1; GDSC2 2.1202 5.5202 1.1108 17.8821
NCI-H2342 GDSC1 2.202 6.5845 0.6838 24.4717
NCI-H1688 GDSC1 2.3135 9.8387 -0.8108 31.213
HARA [Human squamous cell lung carcinoma] GDSC1; GDSC2 2.316 7.8042 0.1957 22.2416
SK-LU-1 GDSC1; GDSC2 2.3807 8.0098 0.1538 22.2262
NCI-H1876 GDSC1; GDSC2 2.4829 6.0753 1.1959 16.0549
NCI-H2172 GDSC1 2.4962 6.7606 0.8739 21.9265
A-427 GDSC1; GDSC2 2.4973 8.271 0.1306 21.9373
NCI-H1299 GDSC1; GDSC2 2.5935 5.275 1.6874 12.6752
NCI-H1755 GDSC1; GDSC2 2.5984 4.9074 1.8675 11.5514
NCI-H2347 GDSC1 2.6017 5.4448 1.6134 16.273
LXF 289 GDSC1; GDSC2 2.6291 5.7076 1.5119 13.6284
EMC-BAC-2 GDSC1; GDSC2 2.6616 5.4535 1.6659 12.5688
SW1271 GDSC1; GDSC2 2.6856 5.588 1.623 12.7504
NCI-H2722 GDSC1; GDSC2 2.7549 6.4525 1.2622 14.7255
NCI-H1048 GDSC1; GDSC2 2.7745 7.256 0.8819 16.9164
EPLC-272H GDSC1; GDSC2 2.8093 4.5073 2.262 8.3664
HOP-62 GDSC1; GDSC2 2.841 7.2055 0.9661 16.2082
COR-L279 GDSC1 2.8835 5.5362 1.8311 13.4194
Lu-134-A GDSC1 2.8858 5.1451 2.0255 11.9137
DMS 114 GDSC1; GDSC2 2.8964 9.5926 -0.1748 22.0998
NCI-H226 GDSC1; GDSC2 2.9001 10.1637 -0.4565 23.3784
RERF-LC-Sq1 GDSC1; GDSC2 2.9365 6.766 1.269 14.0925
NCI-H596 GDSC1; GDSC2 2.9397 8.9159 0.2004 20.1103
Lu-135 GDSC1; GDSC2 2.9574 5.1035 2.1117 8.7921
COR-L105 GDSC1; GDSC2 3.0187 7.7595 0.8457 16.3383
NCI-H2110 GDSC1 3.0191 6.5671 1.4406 15.8008
NCI-H2804 GDSC1; GDSC2 3.0358 9.0165 0.2329 19.6371
NCI-H1304 GDSC1 3.041 5.69 1.8963 12.279
HOP-92 GDSC1; GDSC2 3.0419 5.6828 1.9007 9.8429
NCI-H1703 GDSC1 3.0555 5.227 2.1391 10.3353
NCI-H3122 GDSC1; GDSC2 3.1033 7.5752 1.0105 15.1138
LOU-NH91 GDSC1; GDSC2 3.1071 5.8933 1.8531 9.9381
NCI-H460 GDSC1 3.1309 4.4991 2.5674 6.6803
NCI-H2803 GDSC1; GDSC2 3.1318 9.5531 0.0465 20.281
NCI-H2023 GDSC1; GDSC2 3.1575 5.9843 1.8514 9.7937
NCI-H82 GDSC1; GDSC2 3.1635 5.4478 2.1243 8.0557
NCI-H1155 GDSC1; GDSC2 3.1652 5.0705 2.3138 6.8532
NCI-H1792 GDSC1; GDSC2 3.2241 5.5416 2.1296 7.8378
EKVX GDSC1; GDSC2 3.2764 6.573 1.6583 10.6462
UMC-11 GDSC1; GDSC2 3.281 4.8234 2.5368 5.0913
IST-SL1 GDSC1 3.2879 6.0482 1.9303 11.0709
NCI-H1869 GDSC1; GDSC2 3.2908 8.7106 0.6016 16.8774
COR-L32 GDSC1 3.2914 7.7294 1.0927 17.2088
NCI-H2122 GDSC1; GDSC2 3.2965 8.4422 0.7406 16.0831
NCI-H2405 GDSC1; GDSC2 3.2965 6.865 1.5291 11.3894
NCI-H322M GDSC1; GDSC2 3.3018 5.9492 1.9915 8.4791
NCI-H1975 GDSC1; GDSC2 3.3134 6.6037 1.674 10.4392
NCI-H1437 GDSC1 3.3144 4.9085 2.5224 6.3327
COR-L23 GDSC1; GDSC2 3.3205 5.5212 2.2211 6.9737
NCI-H1666 GDSC1; GDSC2 3.3323 5.8662 2.0585 7.9674
VMRC-LCD GDSC1; GDSC2 3.3625 4.9062 2.5634 4.686
PaCa-3 GDSC1 3.3632 6.3783 1.828 11.5849
NCI-H2227 GDSC1; GDSC2 3.3765 8.2672 0.8946 14.9639
NCI-H1563 GDSC1; GDSC2 3.3836 8.288 0.8901 14.9691
PC-14 GDSC1; GDSC2 3.4004 6.5982 1.7487 9.7205
SK-MES-1 GDSC1; GDSC2 3.4024 5.3493 2.3745 5.7686
RERF-LC-KJ GDSC1; GDSC2 3.413 5.1325 2.4913 5.0001
HCC366 GDSC1; GDSC2 3.4133 6.654 1.7314 9.7918
NCI-H2461 GDSC1; GDSC2 3.4321 8.2136 0.9673 14.3793
NCI-H2595 GDSC1; GDSC2 3.4351 9.5236 0.3149 17.99
SBC-1 GDSC1 3.4497 5.9741 2.1007 9.1661
LCLC-97TM1 GDSC1; GDSC2 3.4613 9.7242 0.2362 18.3218
NCI-H2444 GDSC1 3.4978 9.2473 0.5045 20.1838
NCI-H358 GDSC1; GDSC2 3.4999 9.2309 0.5145 16.7342
NCI-H1944 GDSC1; GDSC2 3.5012 8.6718 0.7949 15.1713
NCI-H2591 GDSC1; GDSC2 3.5124 11.0063 -0.3627 21.0816
COR-L311 GDSC2 3.5267 7.191 1.5553 10.5665
IA-LM GDSC1; GDSC2 3.5296 8.7393 0.7843 15.1494
NCI-H1793 GDSC1; GDSC2 3.531 10.6239 -0.1563 20.0651
NCI-H650 GDSC1; GDSC2 3.5838 6.6057 1.8929 8.3067
SBC-5 GDSC1; GDSC2 3.6154 5.0933 2.6673 3.3656
NCI-H2087 GDSC1; GDSC2 3.623 7.0825 1.6863 9.4898
NCI-H2170 GDSC1; GDSC2 3.6429 8.1115 1.1891 12.4696
NCI-H1915 GDSC1; GDSC2 3.645 6.0283 2.2276 6.0435
DMS 53 GDSC1; GDSC2 3.6588 9.2627 0.6275 15.6586
KNS-62 GDSC1; GDSC2 3.6675 5.086 2.7087 2.9861
LCLC-103H GDSC1; GDSC2 3.6907 5.4619 2.5416 3.9662
NCI-H720 GDSC1; GDSC2 3.7035 5.6565 2.4554 4.4716
NCI-H1650 GDSC1; GDSC2 3.7173 6.5046 2.0469 6.9907
LB647-SCLC GDSC1 3.7231 6.9442 1.8333 10.3056
NCI-H727 GDSC1; GDSC2 3.7238 10.755 -0.0652 19.0715
Ms-1 GDSC1; GDSC2 3.739 5.4037 2.6048 3.462
NCI-H841 GDSC1; GDSC2 3.7655 9.4556 0.6165 15.42
BEN GDSC1 3.7675 9.5116 0.5902 18.7172
NCI-H1838 GDSC1 3.7799 5.6459 2.5159 4.8771
NCI-H2291 GDSC1 3.7808 8.0412 1.333 13.7943
NCI-H1355 GDSC1; GDSC2 3.7815 9.9136 0.4008 16.5408
CPC-N GDSC1; GDSC2 3.7818 5.719 2.4817 4.1224
NCI-H835 GDSC1 3.7926 6.2564 2.2261 7.0728
SW1573 GDSC1; GDSC2 3.8066 10.6039 0.0765 18.1403
HCC15 GDSC1; GDSC2 3.8154 6.2545 2.2438 5.5177
DMS 273 GDSC1; GDSC2 3.8191 9.878 0.4485 16.1824
NCI-H2066 GDSC1 3.8533 8.1937 1.3135 13.6901
NCI-H526 GDSC1; GDSC2 3.8639 9.4991 0.6726 14.8389
NCI-H1836 GDSC1 3.8669 7.0657 1.8825 9.4735
Lu-165 GDSC1; GDSC2 3.875 7.2201 1.8124 8.0502
Lu-99A GDSC1; GDSC2 3.8777 7.6965 1.5788 9.4814
NCI-H209 GDSC1; GDSC2 3.8872 8.0026 1.4344 10.3369
NCI-H520 GDSC1; GDSC2 3.8998 11.6257 -0.3588 19.9606
NCI-H513 GDSC1; GDSC2 3.9052 7.7241 1.586 9.367
COLO 668 GDSC1; GDSC2 3.9117 6.7543 2.069 6.3704
NCI-H3255 GDSC1; GDSC2 3.9358 9.8335 0.5625 15.2481
NCI-H810 GDSC1; GDSC2 3.973 9.3907 0.8116 13.7678
Calu-3 GDSC1; GDSC2 3.9828 8.9214 1.0521 12.3623
Calu-6 GDSC1; GDSC2 4.015 8.9813 1.047 12.3079
HCC827 GDSC1; GDSC2 4.0331 7.3625 1.8593 7.3734
NCI-H1770 GDSC1 4.071 6.0847 2.5038 4.1893
LC-1/sq GDSC1; GDSC2 4.0839 8.5948 1.2905 10.6989
NCI-H2369 GDSC1; GDSC2 4.1077 8.1331 1.5357 9.1679
ABC-1 GDSC1; GDSC2 4.1114 6.1543 2.4972 3.3227
NCI-H146 GDSC1 4.1128 6.7124 2.232 6.1101
COR-L95 GDSC1 4.1281 7.9284 1.6512 10.3961
NCI-H1651 GDSC1; GDSC2 4.1572 8.3445 1.4682 9.4546
EBC-1 GDSC1; GDSC2 4.1628 8.9293 1.1844 11.1279
NCI-H2141 GDSC1; GDSC2 4.1653 9.0617 1.121 11.493
NCI-H522 GDSC1; GDSC2 4.1923 6.9608 2.1668 5.1347
DMS 79 GDSC1; GDSC2 4.1958 6.6329 2.3258 4.1724
NCI-H2081 GDSC1 4.1963 7.1581 2.0746 7.0625
NCI-H211 GDSC1; GDSC2 4.204 6.3757 2.4527 3.4051
NCI-H2029 GDSC1; GDSC2 4.2378 10.5159 0.4568 15.0169
NCI-H661 GDSC1; GDSC2 4.2538 7.183 2.1019 5.3948
NCI-H1963 GDSC2 4.3136 6.4581 2.483 3.0262
NCI-H345 GDSC1; GDSC2 4.315 5.5823 2.8727 0.9519
NCI-H1092 GDSC1; GDSC2 4.3253 7.5106 1.9933 5.8962
NCI-H1435 GDSC1; GDSC2 4.3275 6.303 2.5626 2.5513
NCI-H69 GDSC1 4.5763 8.4271 1.7239 8.6077
ChaGo-K-1 GDSC1 4.5827 10.8046 0.5723 16.205
COR-L321 GDSC1 4.5865 10.4476 0.7501 15.1182
NCI-H1436 GDSC1 4.6194 6.2796 2.7332 1.5598
NCI-H1623 GDSC1; GDSC2 4.6413 8.7003 1.637 7.3461
NCI-H1993 GDSC1; GDSC2 4.672 7.3725 2.2805 3.5476
NCI-H1693 GDSC2 4.7636 10.2279 0.9842 10.8458
COR-L88 GDSC1 4.7758 7.648 2.2169 4.6337
NCI-H23 GDSC1; GDSC2 4.8372 13.0826 -0.3603 17.5351
NCI-H2373 GDSC1; GDSC2 4.8839 14.801 -1.1735 20.8396
NCI-H187 GDSC1 4.9462 6.5165 2.7906 0.8761
NCI-H196 GDSC1; GDSC2 5.0255 9.5834 1.4717 7.514
NCI-H1694 GDSC1; GDSC2 5.0808 6.7381 2.7633 0.7015
NCI-H1105 GDSC1 5.147 6.7666 2.7807 0.7438
Lu-139 GDSC1; GDSC2 5.2356 7.0804 2.698 0.8213
IST-SL2 GDSC1; GDSC2 5.2516 7.4128 2.5733 1.2985
NCI-H1568 GDSC1; GDSC2 5.3046 13.8992 -0.4192 16.6989
NCI-H1781 GDSC1; GDSC2 5.5557 6.7926 2.9264 0.1058
NCI-H2135 GDSC1; GDSC2 5.5747 7.1484 2.8102 0.303
NCI-H250 GDSC2 5.8078 8.1801 2.5209 1.0327
Lu-65 GDSC1; GDSC2 6.0205 7.9385 2.6972 0.3893
SHP-77 GDSC1; GDSC2 6.0471 14.1312 -0.015 13.2396
NCI-H441 GDSC1; GDSC2 7.9732 22.1281 -2.5442 19.2337
⏷ Show the Full List of 177 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1; GDSC2 4.0906 8.3383 1.4219 9.8963
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-8 GDSC1; GDSC2 0.6728 4.9184 -0.1206 30.536
T.T GDSC1 1.0308 6.6653 -0.5027 36.3497
TE-10 GDSC1 2.0882 3.9657 1.7578 17.6809
TE-11 GDSC1 2.1798 4.0127 1.8367 16.6371
KYSE-510 GDSC1 2.4581 4.2932 2.0096 13.9711
KYSE-270 GDSC1; GDSC2 2.8373 6.3639 1.3804 13.7348
KYSE-520 GDSC1; GDSC2 2.9219 7.3842 0.9485 16.0495
OE21 GDSC1; GDSC2 2.9673 6.0884 1.6331 11.754
KYSE-180 GDSC1; GDSC2 3.0041 5.5194 1.9482 9.6657
OE33 GDSC1; GDSC2 3.0291 4.7245 2.3638 6.9752
KYSE-450 GDSC1; GDSC2 3.2539 7.3048 1.2736 13.0819
KYSE-150 GDSC1 3.3572 4.6369 2.6936 4.8294
TE-9 GDSC1; GDSC2 3.4181 7.602 1.2615 12.6716
EC-GI-10 GDSC1; GDSC2 3.426 5.7521 2.1924 6.8536
KYSE-140 GDSC1; GDSC2 3.4963 7.3676 1.4425 11.3462
TE-1 GDSC1; GDSC2 3.4967 6.6694 1.7915 9.1807
TE-15 GDSC1; GDSC2 3.511 5.8415 2.216 6.4705
KYSE-410 GDSC1; GDSC2 3.5992 8.9599 0.7305 15.2537
COLO 680N GDSC1; GDSC2 3.8488 6.6829 2.0578 6.5927
TE-5 GDSC1; GDSC2 3.8674 5.9588 2.4258 4.2707
KYSE-70 GDSC1; GDSC2 4.3498 11.3662 0.121 16.4587
TE-6 GDSC1; GDSC2 4.5198 6.6189 2.5323 2.4068
OE19 GDSC1; GDSC2 4.798 10.6147 0.8204 11.6771
TE-4 GDSC1; GDSC2 5.9813 7.8616 2.7099 0.3755
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A2780 GDSC1; GDSC2 0.448 4.9663 -0.3781 32.7524
EFO-27 GDSC1; GDSC2 0.8734 6.7301 -0.6906 32.0048
DOV13 GDSC1; GDSC2 1.3951 3.4786 1.1744 20.5056
OVTOKO GDSC1; GDSC2 1.5067 5.4877 0.509 23.701
JHOS-4 GDSC1 1.9288 4.8043 1.2423 22.1563
Caov-4 GDSC1 2.0632 8.7087 -0.481 31.0195
OC 314 GDSC1 2.2627 4.5908 1.6783 17.3716
RMG-I GDSC1 2.3465 4.9628 1.5938 17.5879
TOV-21G GDSC1; GDSC2 2.3622 3.9179 2.0677 11.2611
OAW42 GDSC1; GDSC2 2.4133 8.3144 0.0332 22.7143
OVCAR-5 GDSC1; GDSC2 3.0663 7.1194 1.2062 14.0626
OVISE GDSC1; GDSC2 3.0964 6.0135 1.7838 10.4061
JHOS-2 GDSC1 3.1112 5.6056 2.0001 11.1993
TYK-nu GDSC1; GDSC2 3.1815 5.7235 2.0022 8.7706
FU-OV-1 GDSC1 3.2369 7.621 1.1011 17.3573
EFO-21 GDSC1; GDSC2 3.3198 9.7234 0.1194 19.3398
OVCAR-8 GDSC1; GDSC2 3.425 7.1336 1.5013 11.1879
OVK18 GDSC1; GDSC2 3.5358 10.0615 0.1287 18.6525
OVKATE GDSC1 3.6775 7.8612 1.3414 14.0853
TOV-112D GDSC1; GDSC2 3.7733 7.5639 1.5644 9.8413
OVCAR-3 GDSC1; GDSC2 3.8882 8.8412 1.0188 12.806
OV-90 GDSC1; GDSC2 3.9787 7.903 1.553 9.3824
IGROV-1 GDSC1; GDSC2 4.0565 9.5629 0.7905 13.6657
OV56 GDSC1; GDSC2 4.1228 8.9504 1.144 11.4652
ES-2 GDSC1; GDSC2 4.1623 5.9197 2.6386 2.4069
Kuramochi GDSC1; GDSC2 4.1786 10.1071 0.6142 14.323
SK-OV-3 GDSC1; GDSC2 5.089 10.7996 0.9336 10.4063
OAW28 GDSC1; GDSC2 5.1957 10.3409 1.2243 8.57
OVCAR-4 GDSC1; GDSC2 6.1548 16.1465 -0.9105 16.9392
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MZ-PC-1 GDSC1 1.4236 3.5286 1.1903 25.2548
Panc 04.03 GDSC1 1.9178 4.2098 1.4806 20.545
PL4 GDSC1; GDSC2 2.1847 5.1433 1.3494 16.2239
Panc 08.13 GDSC1; GDSC2 2.4009 5.9733 1.1677 16.5141
Panc 03.27 GDSC1 2.4128 4.0922 2.0494 13.9014
SW1990 GDSC1 2.5245 6.9452 0.8093 22.215
CFPAC-1 GDSC1; GDSC2 2.6279 6.1227 1.3081 14.8758
PSN1 GDSC1; GDSC2 2.6735 8.2509 0.2982 20.4769
DAN-G GDSC1; GDSC2 2.8222 5.3127 1.8845 10.6636
PaTu 8902 GDSC1; GDSC2 2.9245 5.2521 2.0084 9.5476
PaTu 8988t GDSC1; GDSC2 2.9844 8.8255 0.284 19.5347
BxPC-3 GDSC1; GDSC2 3.0477 5.1329 2.1789 8.0754
HuP-T4 GDSC1; GDSC2 3.0883 6.5917 1.4885 12.2702
Capan-2 GDSC2 3.0902 7.2662 1.1535 14.3047
HuP-T3 GDSC1; GDSC2 3.1255 6.9228 1.3553 12.9742
HPAF-II GDSC1; GDSC2 3.2263 9.3446 0.2305 19.0572
KP-2 GDSC1; GDSC2 3.3276 6.249 1.8632 9.2122
HPAC GDSC1; GDSC2 3.354 5.2367 2.3912 5.8003
Panc 02.03 GDSC1; GDSC2 3.357 5.6823 2.1708 7.186
Capan-1 GDSC1; GDSC2 3.4227 5.3729 2.3791 5.6827
MIA PaCa-2 GDSC1; GDSC2 3.4232 10.4806 -0.1734 20.4638
KP-1N GDSC1; GDSC2 3.4854 9.4594 0.3884 17.4537
SU.86.86 GDSC1; GDSC2 3.495 6.5899 1.8298 8.9456
Hs 766T GDSC1 3.5012 6.6213 1.8191 11.1628
Panc 10.05 GDSC1; GDSC2 3.8739 6.0593 2.3815 4.5281
SUIT-2 GDSC1; GDSC2 4.278 8.8348 1.316 10.0692
KP-3 GDSC1; GDSC2 4.2937 9.6575 0.9231 12.3102
AsPC-1 GDSC2 4.7715 7.6943 2.1931 3.8676
YAPC GDSC1; GDSC2 4.8223 11.5367 0.388 13.9309
KP-4 GDSC1; GDSC2 5.0536 11.3776 0.63 12.1272
QGP-1 GDSC1; GDSC2 5.6691 18.9864 -2.6506 24.0193
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H GDSC1; GDSC2 -0.1008 5.104 -1.0159 37.9234
NCI-H2452 GDSC1 -0.0721 4.5944 -0.7936 44.4424
IST-Mes1 GDSC1; GDSC2 0.4529 4.1609 -0.0726 31.3813
MPP 89 GDSC1; GDSC2 1.0908 4.2839 0.5702 25.1632
NCI-H28 GDSC1; GDSC2 2.447 6.0086 1.1943 16.1912
NCI-H2052 GDSC2 3.2893 6.4328 1.7392 10.1025
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU145 GDSC1; GDSC2 3.6386 5.1331 2.6648 3.3253
22Rv1 GDSC1; GDSC2 3.7441 7.9698 1.3398 11.2881
VCaP GDSC1; GDSC2 3.913 9.0177 0.9504 13.1361
PC-3 GDSC1; GDSC2 3.9392 9.1045 0.9276 13.1969
LNCaP clone FGC GDSC1; GDSC2 4.0158 8.9127 1.0817 12.1042
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1; GDSC2 3.9121 6.475 2.2061 5.5213
Cancer Drug Sensitivity Data Curated from 57 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-MEL-3 GDSC1 1.2571 5.5637 0.2199 31.9821
CP50-MEL-B GDSC1 1.4414 7.7828 -0.6197 34.553
Hs 940.T GDSC1 1.7201 4.3404 1.2192 23.4101
LOX-IMVI GDSC1; GDSC2 1.8842 4.0003 1.5267 16.3857
A-431 GDSC1 1.9754 5.9986 0.7445 25.1976
COLO 800 GDSC1 1.9931 5.7822 0.8632 24.3631
WT2-iPS GDSC1; GDSC2 2.2075 6.7685 0.6001 20.4813
MZ-MEL-2 GDSC1 2.2628 4.5004 1.7183 17.0776
IST-MEL1 GDSC1 2.316 5.1902 1.4579 18.7237
VMRC-MELG GDSC1 2.3566 5.3319 1.4313 18.7255
Mel Ho GDSC1 2.6843 5.4511 1.6884 15.3489
RPMI-7951 GDSC1; GDSC2 2.7058 5.5728 1.6493 12.5191
DJM-1 GDSC1 2.8512 5.8712 1.6365 15.0296
WM1552C GDSC1; GDSC2 2.9424 4.5242 2.3812 7.1601
A-388 GDSC1 2.972 5.6179 1.8707 12.7527
HMV-II GDSC1; GDSC2 3.0205 5.6753 1.8855 10.0066
A-375 GDSC1; GDSC2 3.0543 6.9591 1.2758 13.6789
G-mel GDSC1; GDSC2 3.0943 6.9991 1.2903 13.4662
IPC-298 GDSC1 3.1188 6.1841 1.7183 13.3377
SK-MEL-28 GDSC1 3.246 10.898 -0.5295 26.393
CHL-1 GDSC1; GDSC2 3.2512 9.2051 0.3212 18.5091
WM35 GDSC1 3.3057 6.4779 1.7304 12.5395
SK-MEL-30 GDSC1 3.3551 6.6558 1.6825 12.7206
WM793 GDSC1; GDSC2 3.4342 5.5754 2.2873 6.231
SK-MEL-2 GDSC1; GDSC2 3.4345 5.8656 2.1426 7.1445
SK-MEL-31 GDSC1 3.4593 5.4887 2.3508 7.1742
Hs 938.T GDSC1 3.6 9.1897 0.6164 19.1465
MeWo GDSC1 3.675 7.504 1.5174 12.8241
RVH-421 GDSC1 3.6941 7.4706 1.549 12.5271
A101D GDSC1; GDSC2 3.7342 9.0805 0.7786 14.6033
COLO 792 GDSC1; GDSC2 3.7781 10.4129 0.149 17.8558
UACC-257 GDSC1; GDSC2 3.8414 6.7522 2.0181 6.8576
M14 GDSC1; GDSC2 3.8598 7.3079 1.7575 8.4273
SH-4 GDSC1; GDSC2 3.8778 6.2369 2.2977 5.0354
SK-MEL-24 GDSC1; GDSC2 3.8869 9.6058 0.6375 14.97
Mel JuSo GDSC1; GDSC2 3.8893 13.4552 -1.28 23.8041
WM278 GDSC1; GDSC2 3.9086 7.3648 1.7662 8.2514
LB2518-MEL GDSC1 3.9246 8.9035 1.0161 15.4874
UACC-62 GDSC1; GDSC2 3.9632 7.6714 1.6557 8.7939
CP66-MEL GDSC1; GDSC2 4.0874 7.9552 1.6081 8.7783
451Lu GDSC1 4.0908 6.933 2.1101 7.0876
COLO 783 GDSC1 4.11 7.5546 1.821 9.1982
MMAc-SF GDSC1 4.139 9.3576 0.9551 15.1921
WM115 GDSC1; GDSC2 4.1426 11.1521 0.068 17.2658
IGR-37 GDSC1; GDSC2 4.1969 10.0392 0.6617 14.0157
LB373-MEL-D GDSC1 4.2678 10.6994 0.3888 18.2425
MZ-MEL-7 GDSC1 4.2848 6.4314 2.4776 3.8721
SK-MEL-5 GDSC1; GDSC2 4.3423 7.3992 2.0582 5.4707
A2058 GDSC2 4.3965 6.6941 2.425 3.21
GAK GDSC1; GDSC2 4.6108 6.7431 2.5285 2.289
COLO 679 GDSC1; GDSC2 4.6971 6.4769 2.6895 1.3666
SK-MEL-1 GDSC1 4.7107 7.0877 2.4317 3.3044
IGR-1 GDSC1; GDSC2 4.8181 6.7578 2.6324 1.4937
G-361 GDSC1; GDSC2 5.145 7.2438 2.5915 1.3254
HT-144 GDSC1; GDSC2 5.4098 7.3279 2.6778 0.7669
COLO 829 GDSC1; GDSC2 7.4185 16.6147 -0.2997 11.9641
EquiPSC Line K2 GDSC1 4.2605 7.4115 1.9966 7.4673
⏷ Show the Full List of 57 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1; GDSC2 2.7963 5.4326 1.8019 11.2649
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
STS-0421 GDSC1 -2.7557 1.511 -2.9185 69.3393
G-401 GDSC1; GDSC2 0.0143 3.5623 -0.3562 34.8978
G-402 GDSC1; GDSC2 1.2415 4.6784 0.5773 24.4598
Rh41 GDSC1; GDSC2 1.4744 5.7775 0.3467 24.6933
Rh18 GDSC1 1.5407 3.4172 1.3511 23.5087
Hs 633.T GDSC1 1.5915 3.3612 1.4225 22.7377
SW982 GDSC1; GDSC2 1.7698 4.8066 1.0772 19.4502
A-204 GDSC1; GDSC2 2.5145 10.6964 -1.0581 27.1066
MFH-ino GDSC1 2.7966 6.7326 1.1612 18.7018
MES-SA GDSC1; GDSC2 2.8103 4.594 2.2217 8.6117
GCT GDSC1; GDSC2 2.8197 6.0293 1.5298 12.874
RD GDSC1; GDSC2 3.0169 4.5535 2.4366 6.5603
KYM-1 GDSC1; GDSC2 3.1417 7.2106 1.2255 13.7131
Rh30 GDSC1; GDSC2 3.2343 7.9376 0.9407 15.1216
SK-UT-1 GDSC1; GDSC2 3.4869 5.8866 2.1744 6.7992
SW872 GDSC1; GDSC2 3.5538 7.2376 1.5538 10.5003
EW-8 GDSC1; GDSC2 3.5552 10.1668 0.0919 18.7811
RKN GDSC1; GDSC2 3.6705 6.5189 2.0038 7.3808
HT-1080 GDSC1; GDSC2 3.7192 5.6803 2.4552 4.4349
VA-ES-BJ GDSC1; GDSC2 4.044 9.5224 0.801 13.6395
SK-LMS-1 GDSC1; GDSC2 5.3929 13.2692 -0.0493 14.792
SW684 GDSC1; GDSC2 6.0569 15.8366 -0.8287 16.8089
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-39 GDSC1 -3.3809 -0.8685 -3.3874 79.8406
KATO III GDSC1; GDSC2 -1.5705 4.5905 -2.4106 49.3574
SNU-16 GDSC1 -0.6918 7.0779 -2.4472 50.0881
Fu97 GDSC1 0.2888 2.5445 0.1871 38.4643
ECC10 GDSC1; GDSC2 0.3414 4.3687 -0.2666 32.81
RERF-GC-1B GDSC1; GDSC2 1.3038 3.4383 1.0867 21.3996
23132/87 GDSC1; GDSC2 2.1169 9.1076 -0.6277 26.7736
AGS GDSC1; GDSC2 2.3961 4.3073 1.9398 11.8769
TMK-1 GDSC1 2.4306 5.4108 1.4658 18.1328
MKN1 GDSC1; GDSC2 2.4364 6.6868 0.8546 18.2257
GCIY GDSC2 2.5529 8.4105 0.1114 21.8431
MKN28 GDSC1; GDSC2 3.4014 5.4454 2.3256 6.0807
SCH GDSC1 3.6288 7.5279 1.4689 13.3359
MKN7 GDSC1 3.6293 6.5537 1.9545 9.6889
NUGC-3 GDSC1; GDSC2 3.8355 8.7414 1.0274 12.8973
NUGC-4 GDSC1; GDSC2 3.8449 8.9117 0.9501 13.3205
HGC-27 GDSC2 3.8512 6.2733 2.2608 5.3267
Hs 746.T GDSC1; GDSC2 3.8927 7.6609 1.6078 9.2654
IM95 GDSC1; GDSC2 4.0518 7.0976 2.0024 6.4506
NCI-N87 GDSC1; GDSC2 4.1278 7.8938 1.6679 8.3175
TGBC11TKB GDSC1; GDSC2 4.1958 6.1045 2.5739 2.7168
MKN45 GDSC1; GDSC2 4.2444 5.6489 2.8075 1.3601
OCUM-1 GDSC1; GDSC2 4.2741 6.5786 2.4023 3.5663
ECC12 GDSC2 4.3026 5.8107 2.7685 1.4795
SNU-5 GDSC1; GDSC2 4.4287 6.1464 2.6905 1.7047
SNU-1 GDSC1; GDSC2 4.4361 6.2283 2.6586 1.8599
SK-GT-2 GDSC1; GDSC2 4.499 9.9441 0.9332 11.7505
RF-48 GDSC1; GDSC2 5.1506 7.3941 2.5324 1.5806
SNG-M GDSC1; GDSC2 2.9743 3.9866 2.6689 5.27
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KMH-2 GDSC1 0.5209 3.5487 0.2003 36.7413
TT GDSC1 2.1574 8.9754 -0.5256 30.7777
B-CPAP GDSC1; GDSC2 2.407 5.0464 1.6148 13.7941
K5 GDSC1; GDSC2 2.6948 6.6864 1.0922 15.9468
CAL-62 GDSC1; GDSC2 2.9525 8.373 0.4823 18.5816
BHT-101 GDSC1; GDSC2 3.1886 5.2497 2.2448 7.2175
WRO GDSC1; GDSC2 3.2421 8.4659 0.6832 16.5704
HTC-C3 GDSC1; GDSC2 3.3333 7.0018 1.4915 11.5139
IHH-4 GDSC1; GDSC2 3.4867 8.0324 1.1026 13.4253
FTC-133 GDSC1; GDSC2 3.7179 7.0307 1.7863 8.6154
ASH-3 GDSC1; GDSC2 3.7328 8.7114 0.9615 13.5603
8505C GDSC1; GDSC2 3.8504 5.8827 2.4507 4.1558
TT2609-C02 GDSC1; GDSC2 3.9033 5.5505 2.647 2.8493
8305C GDSC1; GDSC2 4.1189 11.1243 0.0634 17.3516
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BB49-HNC GDSC1; GDSC2 0.316 4.1385 -0.2129 32.7026
PCI-38 GDSC1 0.4801 4.5189 -0.1725 38.6134
HO-1-u-1 GDSC1 1.5979 3.3654 1.4284 22.6615
Ca9-22 GDSC1; GDSC2 1.6188 6.005 0.3884 23.8841
DOK GDSC1; GDSC2 1.7039 4.6449 1.0773 19.7196
KON GDSC1 1.8837 3.1213 1.8022 18.5054
KOSC-2 GDSC1 1.9175 3.8485 1.6189 19.5732
NCI-H3118 GDSC1; GDSC2 2.0796 5.4005 1.1262 17.9458
PCI-04B GDSC1; GDSC2 2.0941 4.9741 1.3355 16.6545
HSC-2 GDSC1; GDSC2 2.1195 4.8328 1.4246 16.0271
JHU-029 GDSC1 2.2507 3.9663 1.9303 15.5954
BICR 10 GDSC1; GDSC2 2.2692 4.7445 1.616 14.306
PE/CA-PJ15 GDSC1 2.3702 6.6037 0.8333 22.7564
SCC-25 GDSC1 2.4757 5.5963 1.4205 18.2559
HO-1-N-1 GDSC1; GDSC2 2.4777 5.8765 1.2874 15.5234
BB30-HNC GDSC1 2.4916 3.967 2.1842 12.5182
HSC-3 GDSC1; GDSC2 2.4977 5.4055 1.533 13.9616
PCI-15A GDSC1 2.522 5.119 1.6931 16.0366
PCI-30 GDSC1 2.5573 6.1306 1.2387 19.1897
Detroit 562 GDSC1; GDSC2 2.6326 5.4624 1.6342 12.8645
BHY GDSC1 2.7801 4.2905 2.3356 9.9924
CAL-33 GDSC1; GDSC2 2.7992 4.8496 2.0882 9.4763
SCC-15 GDSC1; GDSC2 2.9168 4.9375 2.1558 8.6516
BICR 22 GDSC1; GDSC2 2.9623 6.4414 1.4532 12.8839
OSC-19 GDSC1 3.0026 4.4239 2.4865 7.8437
CAL-27 GDSC1; GDSC2 3.0363 6.0844 1.696 11.1432
JHU-011 GDSC1 3.0979 4.4561 2.5588 6.8825
JHU-022 GDSC1; GDSC2 3.144 5.5645 2.0491 8.5897
SAT [Human HNSCC] GDSC1; GDSC2 3.2728 5.9024 1.9905 8.5707
SKN-3 GDSC1; GDSC2 3.4103 6.3962 1.8578 9.0083
FaDu GDSC1; GDSC2 3.4155 6.7683 1.6761 10.1308
PCI-06A GDSC1 3.5336 5.9269 2.1914 8.1716
SAS GDSC1; GDSC2 3.5462 6.4667 1.9323 8.1611
SCC-4 GDSC1; GDSC2 3.5957 7.3596 1.5264 10.5535
HSC-4 GDSC1; GDSC2 3.7026 5.832 2.3683 5.0171
OSC-20 GDSC1; GDSC2 3.7354 5.7592 2.4283 4.5631
BICR 78 GDSC1; GDSC2 3.7797 7.7098 1.4969 10.2384
SCC-9 GDSC1; GDSC2 5.1333 11.1669 0.7871 11.1088
UPCI-SCC-090 GDSC1; GDSC2 5.6123 7.6635 2.6356 0.7728
LB771-HNC GDSC1; GDSC2 5.9361 14.4019 -0.2199 14.4176
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UM-UC-3 GDSC1 0.747 5.0451 -0.0928 36.5131
RT-112 GDSC1; GDSC2 0.9757 8.883 -1.5936 34.5849
BFTC-905 GDSC1; GDSC2 1.7508 5.3597 0.8145 21.0259
639V GDSC1; GDSC2 1.7774 5.2768 0.8786 20.5566
SW1710 GDSC1; GDSC2 2.1663 5.5286 1.1523 17.464
RT-4 GDSC1; GDSC2 2.2299 6.9023 0.5563 20.6407
T24 GDSC1 2.5065 4.1312 2.13 12.8421
SW780 GDSC1; GDSC2 2.581 6.8939 0.8863 17.5411
5637 GDSC1; GDSC2 2.8883 4.646 2.2711 8.0313
CAL-29 GDSC1; GDSC2 3.009 4.5572 2.4274 6.6441
TCCSUP GDSC1; GDSC2 3.3309 6.5387 1.721 10.0944
J82 GDSC1; GDSC2 3.5062 8.0677 1.1008 13.3801
KU-19-19 GDSC1; GDSC2 3.5455 8.3468 0.9933 13.9005
HT-1197 GDSC1; GDSC2 3.7731 7.1513 1.769 8.5784
HT-1376 GDSC1; GDSC2 4.0157 6.943 2.052 6.2294
647V GDSC1; GDSC2 4.4196 9.8314 0.9305 11.958
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 38 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NT2-D1 GDSC1 -0.7511 2.5944 -0.9477 50.7898
SW962 GDSC1 -0.4283 2.6517 -0.6092 47.2195
PWR-1E GDSC1; GDSC2 -0.3917 3.3416 -0.7363 38.6582
KGN GDSC1 -0.1241 2.9062 -0.334 43.814
SW954 GDSC1 -0.1042 3.99 -0.6187 44.3443
PA-1 GDSC2 0.0701 5.8463 -1.1332 37.3787
NEC8 GDSC1; GDSC2 0.4048 3.6323 0.0485 31.0485
OVMIU GDSC1; GDSC2 0.7063 6.4742 -0.7453 32.9701
ACC-OV7 GDSC1 0.8336 3.9637 0.4074 33.5985
BPH-1 GDSC1; GDSC2 1.1662 4.4293 0.5956 24.6918
TC-YIK GDSC1; GDSC2 1.5471 5.4295 0.5761 23.1725
CAL-39 GDSC1; GDSC2 1.5993 4.0041 1.2198 19.3491
OV17R GDSC1 1.9873 9.3793 -0.8801 32.8796
OVCA433 GDSC1 2.0582 5.305 1.1489 22.1482
JHOS-3 GDSC1 2.1553 5.9578 0.9392 23.0785
OVCA420 GDSC1 2.3256 5.307 1.4127 19.0046
SKN GDSC1; GDSC2 2.4038 5.9355 1.1887 16.378
JEG-3 GDSC1 2.7816 5.787 1.6145 15.4867
HeLa GDSC1; GDSC2 2.9068 7.2769 0.9887 15.8624
ME-180 GDSC1; GDSC2 2.9573 7.4347 0.9543 15.9021
JAR GDSC1 2.9755 4.8472 2.2543 9.7636
LB831-BLC GDSC1; GDSC2 3.2824 7.1948 1.3525 12.5174
SiHa GDSC1; GDSC2 3.3156 7.3241 1.3156 12.6438
OMC-1 [Human cervical carcinoma] GDSC1 3.3825 5.3221 2.3719 7.2751
Ca Ski GDSC1; GDSC2 3.5251 6.0098 2.1433 6.8908
PEO1 GDSC1; GDSC2 3.5452 6.5571 1.8865 8.4519
DSH1 GDSC1; GDSC2 3.6024 6.9876 1.7173 9.3533
C-33 A GDSC1; GDSC2 3.6277 6.47 1.9949 7.5497
HEC-1 GDSC1; GDSC2 3.6861 8.6928 0.9336 13.8509
SKG-IIIa GDSC1; GDSC2 3.6956 6.5881 1.9889 7.4091
HT-3 GDSC1; GDSC2 3.7226 7.602 1.506 10.3345
HEY GDSC1; GDSC2 3.8391 8.3808 1.2095 11.8149
C-4-I GDSC1; GDSC2 3.895 6.9844 1.9436 7.188
UWB1.289 GDSC1 3.94 7.6367 1.6555 10.9422
SW756 GDSC1; GDSC2 4.0291 6.5984 2.2291 5.1126
SiSo GDSC1; GDSC2 4.1128 8.6694 1.2753 10.7166
DoTc2 4510 GDSC1; GDSC2 4.8959 14.7832 -1.1556 20.7412
MS751 GDSC1; GDSC2 5.0364 11.2289 0.6901 11.8449
⏷ Show the Full List of 38 Cancer Drug Sensitivity Data of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7700).
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1818).
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1817).
4 A new ETV6-NTRK3 cell line model reveals MALAT1 as a novel therapeutic target - a short report. Cell Oncol (Dordr). 2018 Feb;41(1):93-101. doi: 10.1007/s13402-017-0356-2. Epub 2017 Nov 8.