Details of the Drug

General Information of Drug (ID: DM0PYEQ)

• Drug Name: NIP-004
• Synonyms: Blood clotting modulator, Nissan; NIP-022; ONO-7746; ONO-7746); Peptidomimetic thrombopoietin agonist (thrombocytopenia), Nissan Chemical; Peptidomimetic thrombopoietin agonist (thrombocytopenia), Nissan Chemical/Ono

Indication

Disease Entry	ICD 11	Status	REF
Thrombocytopenia	3B64	Phase 1	[1]

• #Ro5 Violations (Lipinski): 1:
  Molecular Weight (mw); 455.3
  Logarithm of the Partition Coefficient (xlogp); 5.2
  Rotatable Bond Count (rotbonds); 5
  Hydrogen Bond Donor Count (hbonddonor); 3
  Hydrogen Bond Acceptor Count (hbondacc); 7
• Chemical Identifiers:
  Formula: C18H12Cl2N2O4S2
  IUPAC Name: 5-[[(Z)-1-[5-(3,4-dichlorophenyl)-4-hydroxythiophen-3-yl]ethylideneamino]carbamoyl]thiophene-2-carboxylic acid
  Canonical SMILES: C/C(=N/NC(=O)C1=CC=C(S1)C(=O)O)/C2=CSC(=C2O)C3=CC(=C(C=C3)Cl)Cl
  InChI: InChI=1S/C18H12Cl2N2O4S2/c1-8(21-22-17(24)13-4-5-14(28-13)18(25)26)10-7-27-16(15(10)23)9-2-3-11(19)12(20)6-9/h2-7,23H,1H3,(H,22,24)(H,25,26)/b21-8-
  InChIKey: JYODIYJKYDDIDN-WNFQYIGGSA-N
• Cross-matching ID:
  PubChem CID: 87416054
  TTD ID: D00CLM

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Thrombopoietin receptor (MPL)	TTIHYA4	TPOR_HUMAN	Agonist	[2]

Molecular Expression Atlas of This Drug

• ICD Disease Classification: 03 Disease of the blood or blood-forming organs
• Disease Class: ICD-11: 3B64 Thrombocytopenia
• The Studied Tissue: Whole blood
• The Studied Disease: Thrombocytopenia [ICD-11:3B64]

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Thrombopoietin receptor (MPL)	DTT	MPL	8.96E-01	0.07	0.28

References

• [1] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027636)
• [2] A novel nonpeptidyl human c-Mpl activator stimulates human megakaryopoiesis and thrombopoiesis. Blood. 2006 Jun 1;107(11):4300-7.