General Information of Drug (ID: DM0UPQJ)

Drug Name
Dotinurad
Synonyms
Dotinurad; 1285572-51-1; FYU-981; Dotinurad [INN]; (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone; 305EB53128; (3,5-dichloro-4-hydroxyphenyl)-(1,1-dioxo-2H-1,3-benzothiazol-3-yl)methanone; Urece; Methanone, (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxido-3(2H)-benzothiazolyl)-; Urece (TN); Dotinurad (JAN/INN); DOTINURAD [JAN]; DOTINURAD [WHO-DD]; FYU981; CHEMBL4594446; SCHEMBL10322525; GTPL11389; VOFLAIHEELWYGO-UHFFFAOYSA-N; UNII-305EB53128; EX-A5737; BDBM50561689; AKOS040741664; HY-109031; CS-0030545; D11071; 3-(3,5-dichloro-4-hydroxybenzoyl)-1,1-dioxo-2,3-dihydro-1,3-benzothiazole
Indication
Disease Entry ICD 11 Status REF
Gout FA25 Phase 3 [1]
Drug Type
Small molecule
Structure
3D MOL 2D MOL
Chemical Identifiers
Formula
C14H9Cl2NO4S
Canonical SMILES
C1N(C2=CC=CC=C2S1(=O)=O)C(=O)C3=CC(=C(C(=C3)Cl)O)Cl
InChI
InChI=1S/C14H9Cl2NO4S/c15-9-5-8(6-10(16)13(9)18)14(19)17-7-22(20,21)12-4-2-1-3-11(12)17/h1-6,18H,7H2
InChIKey
VOFLAIHEELWYGO-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
51349053
UNII
305EB53128
DrugBank ID
DB16145
TTD ID
DA29IM

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Urate anion exchanger 1 (URAT1) TTA592U S22AC_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 ClinicalTrials.gov (NCT05007392) A Randomized, Multicenter, Double-Blind, Superiority Study of Dotinurad (4 mg) and Febuxostat (40 mg) for the Treatment of Subjects With Gout. U.S.National Institutes of Health.
2 Dotinurad: a novel selective urate reabsorption inhibitor for the treatment of hyperuricemia and gout. Expert Opin Pharmacother. 2021 Aug;22(11):1397-1406.