Details of the Drug

General Information of Drug (ID: DM0UXNF)

Drug Name
VE-821
Synonyms ATR serine/threonine protein kinase inhibitors (cancer), Oxford University; ATR serine/threonine protein kinase inhibitors (cancer), Vertex Pharmaceuticals
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 368.4
Logarithm of the Partition Coefficient (xlogp) 2.1
Rotatable Bond Count (rotbonds) 4
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C18H16N4O3S
IUPAC Name
3-amino-6-(4-methylsulfonylphenyl)-N-phenylpyrazine-2-carboxamide
Canonical SMILES
CS(=O)(=O)C1=CC=C(C=C1)C2=CN=C(C(=N2)C(=O)NC3=CC=CC=C3)N
InChI
InChI=1S/C18H16N4O3S/c1-26(24,25)14-9-7-12(8-10-14)15-11-20-17(19)16(22-15)18(23)21-13-5-3-2-4-6-13/h2-11H,1H3,(H2,19,20)(H,21,23)
InChIKey
DUIHHZKTCSNTGM-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
51000408
ChEBI ID
CHEBI:124916
CAS Number
1232410-49-9
TTD ID
D0G0BJ
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Serine/threonine-protein kinase ATR (FRP1) TT8ZYBQ ATR_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC2 3.7216 5.5608 2.5156 4.0542
HuO9 GDSC2 0.8751 5.335 -0.0778 29.3956
NOS-1 [Human HNSCC] GDSC2 1.4973 7.4226 -0.3943 28.1418
CAL-72 GDSC2 1.9602 6.0058 0.7262 20.7036
EW-22 GDSC2 1.9789 8.2095 -0.3149 25.9248
EW-3 GDSC2 2.2442 8.4736 -0.1993 24.4272
EW-12 GDSC2 2.5237 5.8912 1.3237 15.1423
EW-18 GDSC2 2.6777 6.9993 0.9221 17.0055
ES5 GDSC2 3.2244 12.4647 -1.331 25.8868
ES1 GDSC2 3.461 6.7521 1.7213 9.7191
SK-PN-DW GDSC2 3.6094 7.5863 1.4243 11.1416
CHSA0011 GDSC2 3.6198 10.4532 0.0014 19.0432
CADO-ES1 GDSC2 3.6765 5.8569 2.3364 5.2812
SK-ES-1 GDSC2 3.7232 7.3619 1.6259 9.5955
CAL-78 GDSC2 3.9157 6.7731 2.0627 6.3994
CHSA8926 GDSC2 4.0919 6.0258 2.5452 3.0778
EW-11 GDSC2 4.1719 10.5101 0.4093 15.4396
ES8 GDSC2 4.2957 8.2579 1.6109 8.2671
SaOS-2 GDSC2 4.3259 6.6939 2.3812 3.5915
HOS GDSC2 4.3365 6.8807 2.3004 4.0437
TC-71 GDSC2 4.3675 7.5077 2.0232 5.6274
ES4 GDSC2 4.4227 8.595 1.5369 8.4188
SJSA-1 GDSC2 4.4594 7.5455 2.0662 5.1829
CHSA0108 GDSC2 4.4872 11.5992 0.1097 16.165
U2OS GDSC2 4.6207 8.2204 1.8521 6.1213
EW-1 GDSC2 4.7047 7.7976 2.1046 4.4883
NY GDSC2 4.8825 8.5816 1.851 5.6153
EW-7 GDSC2 4.8893 6.9434 2.5904 1.6082
U-CH2 GDSC2 4.8972 11.808 0.3093 14.1586
ES7 GDSC2 4.9761 8.3188 2.0304 4.428
EW-24 GDSC2 5.1197 28.5538 -7.8289 34.8698
A-673 GDSC2 5.1773 15.0769 -1.0901 19.815
ES6 GDSC2 5.2833 13.8559 -0.4134 16.7215
MHH-ES-1 GDSC2 5.4497 9.0835 1.9616 4.0367
EW-16 GDSC2 5.5871 8.0559 2.4707 1.4096
H-EMC-SS GDSC2 5.5912 9.4524 1.8775 4.2663
HuO-3N1 GDSC2 5.6914 7.8389 2.6021 0.832
G-292 clone A141B1 GDSC2 5.7949 7.7016 2.6957 0.4899
MG-63 GDSC2 6.0331 19.6429 -2.7041 23.406
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 164 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC2 2.7424 7.344 0.8096 17.4391
JURL-MK1 GDSC2 -0.3282 1.6242 -0.357 36.7676
A3/Kawakami GDSC2 -0.0421 1.4624 -0.0521 33.8079
SUP-B8 GDSC2 0.1645 3.1115 -0.0688 32.8226
BALL-1 GDSC2 0.2058 2.2883 0.1375 31.6126
BV-173 GDSC2 0.3524 3.7686 -0.051 31.7822
MOLM-13 GDSC2 0.466 2.2114 0.4235 28.8746
HAL-01 GDSC2 0.5181 3.285 0.272 29.3893
IM-9 GDSC2 0.6011 4.5853 -0.0677 30.6351
MOLT-16 GDSC2 0.6299 1.7481 0.6248 27.0401
NU-DUL-1 GDSC2 0.6345 2.1187 0.6097 27.094
EoL-1 GDSC2 0.6483 2.5737 0.5691 27.234
NALM-6 GDSC2 0.6899 5.8763 -0.5004 32.0932
DEL GDSC2 0.7231 2.867 0.5957 26.7346
NK-92MI GDSC2 0.7579 2.8974 0.6272 26.403
RCH-ACV GDSC2 0.9621 3.9551 0.5495 25.8563
SU-DHL-5 GDSC2 0.9706 2.5569 0.917 23.8695
SIG-M5 GDSC2 0.9872 2.0066 0.9812 23.4595
HEL GDSC2 0.993 2.7287 0.9143 23.7754
OCI-Ly7 GDSC2 0.993 2.9926 0.862 24.0497
KE-37 GDSC2 1.0017 2.597 0.9446 23.5759
SCC-3 GDSC2 1.1352 4.3893 0.578 24.9238
ATN-1 GDSC2 1.155 2.7051 1.0924 22.0661
NB4 GDSC2 1.1588 2.4695 1.1279 21.8644
VAL GDSC2 1.2265 6.8808 -0.4061 29.3118
BL-41 GDSC2 1.2459 2.2779 1.2347 20.8899
WSU-DLCL2 GDSC2 1.2801 4.0091 0.8743 22.6709
KOPN-8 GDSC2 1.2827 3.9092 0.9123 22.4499
Ku812 GDSC2 1.3351 8.5975 -1.1116 31.5936
BC-3 GDSC2 1.3369 3.465 1.1149 21.0953
697 GDSC2 1.3717 3.6235 1.1042 20.9963
Karpas-299 GDSC2 1.3941 3.6086 1.1333 20.7352
MEG-01 GDSC2 1.4175 3.4615 1.2038 20.2433
GA-10 GDSC2 1.4984 3.0565 1.3975 18.8238
EJM GDSC2 1.514 4.7909 0.8177 21.9775
OCI-M1 GDSC2 1.5298 2.7285 1.4904 18.1857
Farage GDSC2 1.5411 3.54 1.3148 19.0757
OPM-2 GDSC2 1.5414 3.7904 1.2333 19.5257
TK [Human B-cell lymphoma] GDSC2 1.577 3.3837 1.4004 18.4434
KCL-22 GDSC2 1.5821 3.4129 1.3976 18.4362
OCI-Ly19 GDSC2 1.5993 5.4204 0.6333 22.6464
JeKo-1 GDSC2 1.625 3.3188 1.4709 17.8406
CCRF-CEM GDSC2 1.6724 5.3891 0.7217 21.8613
SU-DHL-16 GDSC2 1.6727 5.4314 0.7031 21.9631
RS4;11 GDSC2 1.7021 3.703 1.4371 17.6801
HT GDSC2 1.7293 7.3917 -0.1556 26.147
MC116 GDSC2 1.7715 6.4527 0.3313 23.5758
L-1236 GDSC2 1.7855 5.3055 0.874 20.5504
CRO-AP2 GDSC2 1.8413 3.8702 1.5291 16.5558
RPMI-8866 GDSC2 1.8616 5.0433 1.0683 19.1323
MOLM-16 GDSC2 1.8732 5.8062 0.7335 20.9983
SUP-M2 GDSC2 1.8828 4.333 1.394 17.1557
DND-41 GDSC2 1.9343 3.8988 1.6185 15.6484
Ramos.2G6.4C10 GDSC2 1.9548 4.8922 1.2304 17.8187
H9 GDSC2 2.0726 5.6711 0.9935 18.7477
WSU-NHL GDSC2 2.113 4.364 1.6222 14.8848
EB2 GDSC2 2.1248 7.2232 0.3017 22.3867
Raji GDSC2 2.1357 4.2004 1.7142 14.2532
GR-ST GDSC2 2.2051 5.5209 1.1941 17.0716
Karpas-231 GDSC2 2.2496 3.8366 1.9797 12.241
Kasumi-1 GDSC2 2.2816 7.3324 0.3951 21.3245
JVM-3 GDSC2 2.2872 5.0671 1.4867 15.0143
Namalwa GDSC2 2.4228 5.3804 1.4728 14.5977
Loucy GDSC2 2.4461 4.2293 2.0252 11.1716
SU-DHL-8 GDSC2 2.4636 3.7341 2.2474 9.799
BC-1 GDSC2 2.5006 5.5365 1.473 14.3167
SKM-1 GDSC2 2.509 5.4943 1.5013 14.1145
NOMO-1 GDSC2 2.5257 4.6065 1.9366 11.3978
BE-13 GDSC2 2.5504 5.4287 1.5723 13.5336
BONNA-12 GDSC2 2.5658 4.4618 2.0431 10.6019
LAMA-84 GDSC2 2.5685 4.8002 1.8888 11.5301
CTB-1 GDSC2 2.6684 5.7244 1.5404 13.318
THP-1 GDSC2 2.7509 6.9712 1.002 16.293
OCI-AML-2 GDSC2 2.7637 4.7521 2.1012 9.5209
CML-T1 GDSC2 2.7708 4.2409 2.3493 7.9732
TALL-1 [Human adult T-ALL] GDSC2 2.7859 5.7165 1.653 12.2244
A4/Fukuda GDSC2 2.8173 4.3841 2.3282 7.931
P32/ISH GDSC2 2.8189 3.9307 2.5386 6.6468
ML-2 GDSC2 2.8241 4.0556 2.4876 6.9337
SR GDSC2 2.8276 6.0979 1.5031 13.0124
SU-DHL-4 GDSC2 2.8584 4.6405 2.2454 8.2951
RPMI-8402 GDSC2 2.8636 4.6416 2.2498 8.2499
GDM-1 GDSC2 2.8784 5.5905 1.7997 11.0044
HC-1 GDSC2 2.9338 4.0795 2.5855 5.9289
SU-DHL-10 GDSC2 2.996 5.1075 2.1448 8.4577
MHH-PREB-1 GDSC2 3.0078 4.4852 2.4615 6.4355
Mono-Mac-6 GDSC2 3.0124 5.9163 1.7585 10.8281
SUP-T1 GDSC2 3.0227 7.488 0.9846 15.5176
SU-DHL-6 GDSC2 3.0291 4.5473 2.4509 6.4294
WIL2 NS GDSC2 3.0582 4.2996 2.5991 5.4058
JSC-1 GDSC2 3.0993 6.5481 1.5198 12.0425
ALL-SIL GDSC2 3.1881 5.3351 2.2017 7.4909
SU-DHL-1 GDSC2 3.2008 12.392 -1.3144 25.8966
MOLP-8 GDSC2 3.2154 4.5025 2.6407 4.6335
EM-2 GDSC2 3.2221 4.5939 2.6009 4.8638
DoHH2 GDSC2 3.2289 4.4909 2.6582 4.4809
SUP-B15 GDSC2 3.2421 4.9795 2.4257 5.9107
AMO1 GDSC2 3.2472 6.5011 1.6697 10.6618
ARH-77 GDSC2 3.2538 5.0736 2.3887 6.1097
KG-1 GDSC2 3.2691 5.4413 2.2179 7.1445
Daudi GDSC2 3.2723 5.1924 2.345 6.3307
MHH-CALL-4 GDSC2 3.2835 7.0675 1.4171 12.1184
DB GDSC2 3.3105 5.8925 2.0271 8.229
Karpas-45 GDSC2 3.3134 5.488 2.2318 6.9266
P31/FUJ GDSC2 3.3166 6.026 1.9654 8.6003
Karpas-422 GDSC2 3.3275 5.3424 2.3163 6.3507
KMS-11 GDSC2 3.3302 6.7474 1.6161 10.7511
Hs 445 GDSC2 3.3441 5.04 2.4813 5.2586
P12-Ichikawa GDSC2 3.3464 6.7365 1.6349 10.5864
DG-75 GDSC2 3.3518 6.474 1.7707 9.7226
CA46 GDSC2 3.3579 5.6596 2.1829 7.1073
QIMR-WIL GDSC2 3.3621 5.7171 2.1576 7.2548
JJN-3 GDSC2 3.3784 8.3963 0.8317 15.3205
Karpas-1106P GDSC2 3.3804 5.43 2.3162 6.1997
MOLT-4 GDSC2 3.4215 5.3006 2.4144 5.4631
Granta-519 GDSC2 3.4252 6.5092 1.8135 9.2438
ST486 GDSC2 3.4332 5.9879 2.0805 7.5408
KMS-12-BM GDSC2 3.4392 5.1258 2.5158 4.773
PL-21 GDSC2 3.4471 6.8842 1.644 10.2409
PF-382 GDSC2 3.4582 5.7603 2.2144 6.6255
P30/OHK GDSC2 3.4623 5.3996 2.3977 5.4561
RPMI-6666 GDSC2 3.4703 5.7111 2.2486 6.3758
MOLT-13 GDSC2 3.53 5.7706 2.2664 6.1015
RPMI-8226 GDSC2 3.5326 5.2171 2.5436 4.3483
OCI-AML-3 GDSC2 3.5396 6.5521 1.8844 8.48
Jurkat GDSC2 3.6137 7.7748 1.3338 11.6806
CTV-1 GDSC2 3.6411 5.2966 2.5863 3.8079
MLMA GDSC2 3.6647 7.5738 1.4745 10.6837
U-698-M GDSC2 3.6755 7.3142 1.6123 9.8066
JVM-2 GDSC2 3.6838 7.0572 1.7466 8.9518
OCI-AML-5 GDSC2 3.7156 5.6836 2.451 4.47
MHH-CALL-2 GDSC2 3.7223 6.4671 2.0693 6.8372
L-428 GDSC2 3.8091 5.5082 2.6034 3.313
L-540 GDSC2 3.8106 7.1424 1.8021 8.2767
L-363 GDSC2 3.8173 6.9671 1.8939 7.6895
KMOE-2 GDSC2 3.8205 5.7231 2.5072 3.877
LC4-1 GDSC2 3.8535 7.7083 1.5545 9.6928
Jiyoye GDSC2 3.8933 8.7743 1.056 12.5756
ALL-PO GDSC2 3.905 9.4774 0.7156 14.4886
K-562 GDSC2 3.9641 5.9551 2.4944 3.6404
KY821 GDSC2 3.9848 5.6472 2.6544 2.6433
KM-H2 GDSC2 4.0028 6.3778 2.3175 4.6309
MM1.S GDSC2 4.0085 8.6997 1.1816 11.5366
SUP-HD1 GDSC2 4.0605 8.4857 1.3267 10.5418
Karpas-620 GDSC2 4.1445 6.6375 2.2894 4.4961
NCI-H929 GDSC2 4.1557 6.5837 2.3226 4.2737
TUR GDSC2 4.1956 5.9749 2.6335 2.378
HDLM-2 GDSC2 4.2347 9.2462 1.0818 11.5471
CESS GDSC2 4.2795 8.7399 1.3636 9.7835
Reh GDSC2 4.3778 6.2233 2.628 2.1102
HH [Human lymphoma] GDSC2 4.3842 8.6985 1.4593 8.9687
RL GDSC2 4.4705 7.9585 1.8769 6.2846
U266B1 GDSC2 4.4885 7.9328 1.9013 6.1021
ROS-50 GDSC2 4.6003 7.8794 2.0001 5.2922
VL51 GDSC2 4.6572 7.0368 2.424 2.7791
RC-K8 GDSC2 4.732 8.2709 1.9007 5.6157
NKM-1 GDSC2 5.0731 10.4277 1.1012 9.5115
MY-M12 GDSC2 5.0823 14.9881 -1.117 20.1447
ME1 GDSC2 5.1635 7.5266 2.4835 1.7903
HL-60 GDSC2 5.3013 6.5404 2.9227 0.1667
YT GDSC2 5.4652 6.6925 2.9288 0.1195
SK-MM-2 GDSC2 5.6444 7.2485 2.8009 0.2982
LP-1 GDSC2 6.0153 16.6077 -1.2322 18.5014
MN-60 GDSC2 6.0526 7.9344 2.7108 0.3473
⏷ Show the Full List of 164 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESO-51 GDSC2 1.3777 3.4342 1.1684 20.6177
KYSE-50 GDSC2 3.6986 6.1951 2.186 6.1674
KYSE-220 GDSC2 3.7611 8.8789 0.9004 13.8346
OACP4 C GDSC2 3.9089 7.5274 1.6861 8.744
TE-12 GDSC2 4.2615 9.9483 0.7554 13.3326
FLO-1 GDSC2 4.3609 11.259 0.1825 16.1211
ESO-26 GDSC2 4.529 7.4444 2.1588 4.5023
OACM5.1 C GDSC2 4.8301 7.7948 2.1824 3.828
HCE-4 GDSC2 5.2006 7.6906 2.4333 1.9832
SK-GT-4 GDSC2 5.6726 7.9879 2.5364 1.0791
KYAE-1 GDSC2 5.6931 7.9788 2.5489 1.0173
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC2 4.176 7.17 2.0548 5.8484
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
GOTO GDSC2 1.5038 5.9027 0.3198 24.7117
SK-N-MC-IXC GDSC2 1.5156 5.8092 0.374 24.3806
KP-N-YS GDSC2 2.067 4.6398 1.4562 16.0464
SJNB-14 GDSC2 2.2676 8.0441 0.0334 23.2287
Kelly GDSC2 2.3115 4.7937 1.6364 14.022
CHP-126 GDSC2 2.5457 4.4687 2.0198 10.8186
KP-N-RT-BM-1 GDSC2 2.9667 5.069 2.1372 8.6013
SJNB-6 GDSC2 3.3407 4.8569 2.57 4.7062
SK-N-DZ GDSC2 3.3525 4.9593 2.5286 4.9345
SiMa GDSC2 3.3607 5.1613 2.4344 5.5078
IMR-5 GDSC2 3.3726 5.1672 2.4412 5.4308
NB69 GDSC2 3.4794 6.3748 1.9246 8.3936
LA-N-6 GDSC2 3.552 5.5055 2.4154 5.1045
CHP-212 GDSC2 3.6094 8.9525 0.7425 15.1573
SJNB-17 GDSC2 3.6543 7.1351 1.6848 9.4149
NB(TU)1 GDSC2 3.8865 6.1462 2.3482 4.704
MHH-NB-11 GDSC2 4.067 6.8311 2.1429 5.5547
SK-N-BE(2)-M17 GDSC2 4.1012 5.9216 2.5999 2.7403
SJNB-5 GDSC2 4.1667 7.579 1.8497 7.1186
SK-N-SH GDSC2 4.2269 8.4157 1.4842 9.1898
NH-12 GDSC2 4.2768 9.498 0.9891 11.9761
SK-N-FI GDSC2 4.5748 13.3788 -0.7043 19.6995
SJNB-7 GDSC2 4.5751 6.7747 2.4942 2.5268
TGW GDSC2 4.8283 6.7087 2.6581 1.363
CHP-134 GDSC2 4.8463 6.6548 2.6892 1.204
GI-ME-N GDSC2 5.1184 9.3186 1.6558 6.2863
SK-N-AS GDSC2 5.3422 8.0574 2.3504 2.208
NB1 GDSC2 5.6727 10.2095 1.584 5.7041
SJNB-10 GDSC2 5.7171 7.5679 2.7139 0.4784
SJNB-12 GDSC2 6.3969 8.7635 2.5448 0.6048
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC2 4.246 8.204 1.6016 8.4388
Cancer Drug Sensitivity Data Curated from 51 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC1806 GDSC2 0.9578 3.3635 0.7305 24.9133
HCC1569 GDSC2 2.1866 6.5342 0.6935 20.0385
HCC1143 GDSC2 2.3562 5.0421 1.5667 14.2734
MDA-MB-361 GDSC2 2.5714 4.4113 2.0717 10.407
DU4475 GDSC2 2.6722 6.6864 1.0717 16.1441
Hs 578T GDSC2 3.0488 7.9968 0.7532 16.7722
CAL-51 GDSC2 3.3728 8.9601 0.5451 16.9419
HCC1599 GDSC2 3.5647 5.7394 2.309 5.741
MDA-MB-157 GDSC2 3.5814 6.5693 1.9091 8.2114
HCC2218 GDSC2 3.6564 5.9999 2.2505 5.8708
MDA-MB-231 GDSC2 3.745 18.7303 -4.0326 31.8509
AU565 GDSC2 3.7533 7.3176 1.6713 9.2355
HCC38 GDSC2 3.7879 6.9004 1.9047 7.6976
HCC1395 GDSC2 3.9452 8.7378 1.1143 12.0972
JIMT-1 GDSC2 3.9579 6.9852 1.9895 6.7513
CAL-148 GDSC2 3.9739 8.2201 1.3926 10.3664
HCC1937 GDSC2 4.4313 7.129 2.2444 4.1891
COLO 824 GDSC2 4.4781 8.9095 1.4233 8.9659
MFM-223 GDSC2 4.6713 12.9876 -0.4376 18.2918
MDA-MB-468 GDSC2 4.7077 7.1741 2.3914 2.8766
MDA-MB-453 GDSC2 4.7805 7.1964 2.4228 2.5966
CAL-120 GDSC2 4.7813 6.7173 2.6308 1.5446
BT-474 GDSC2 4.8134 6.5388 2.721 1.099
BT-549 GDSC2 4.8174 8.8966 1.6607 6.843
MDA-MB-330 GDSC2 4.8517 10.0328 1.1399 9.7702
EFM-192A GDSC2 4.9439 7.1754 2.52 1.8792
OCUB-M GDSC2 5.0365 14.7091 -1.0136 19.8435
HCC1187 GDSC2 5.246 6.9481 2.7533 0.6229
MDA-MB-175-VII GDSC2 5.2728 15.3022 -1.1303 19.7511
MRK-nu-1 GDSC2 5.2853 6.8031 2.8233 0.3927
MCF-7 GDSC2 5.2912 7.4257 2.5866 1.2061
HDQ-P1 GDSC2 5.3144 7.3192 2.6395 0.9772
UACC-893 GDSC2 5.3397 11.8037 0.622 11.5436
HCC1954 GDSC2 5.3905 7.2183 2.7114 0.667
BT-483 GDSC2 5.4428 6.8078 2.8812 0.2019
MDA-MB-436 GDSC2 5.4435 7.0948 2.779 0.4355
HCC1500 GDSC2 5.4989 7.3231 2.7168 0.5843
HCC70 GDSC2 5.5183 7.7754 2.551 1.1487
HCC1419 GDSC2 5.5679 7.0386 2.8464 0.2304
HCC2157 GDSC2 5.5708 6.9469 2.8792 0.171
Evsa-T GDSC2 5.6033 7.2888 2.7709 0.3836
YMB-1-E GDSC2 5.6713 7.6784 2.6545 0.6748
ZR-75-30 GDSC2 5.68 7.6562 2.6664 0.6332
T-47D GDSC2 5.7215 8.1844 2.4809 1.2502
UACC-812 GDSC2 5.7678 7.3757 2.8019 0.2552
HCC1428 GDSC2 5.7948 7.3627 2.8162 0.2204
BT-20 GDSC2 5.8025 7.2037 2.8734 0.1296
MDA-MB-415 GDSC2 5.9882 7.7276 2.7597 0.2691
CAMA-1 GDSC2 6.0689 8.2646 2.5978 0.6221
CAL-85-1 GDSC2 6.2897 8.3371 2.657 0.3792
EFM-19 GDSC2 6.4443 8.5047 2.6553 0.331
⏷ Show the Full List of 51 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 55 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D283 Med GDSC2 2.0617 5.3551 1.1293 17.9957
H4 GDSC2 2.3742 5.0841 1.5649 14.2175
LNZTA3WT4 GDSC2 2.8975 6.1856 1.5227 12.6634
ONS-76 GDSC2 3.0403 4.7046 2.3838 6.8123
8-MG-BA GDSC2 3.4111 4.8903 2.6107 4.2504
D-245MG GDSC2 3.6171 11.788 -0.6677 22.1226
D-263MG GDSC2 3.7097 6.2274 2.1783 6.1874
MOG-G-UVW GDSC2 3.8221 6.8632 1.9489 7.3356
D-542MG GDSC2 3.8739 9.8159 0.5227 15.6324
D-566MG GDSC2 3.9053 6.4138 2.2311 5.3832
LN-18 GDSC2 3.9342 8.8959 1.0273 12.6345
U-118MG GDSC2 3.9725 5.7974 2.5754 3.1362
NMC-G1 GDSC2 3.9852 10.7653 0.1376 17.3409
SF295 GDSC2 4.1024 6.2025 2.4686 3.51
Onda 10 GDSC2 4.2074 6.4964 2.398 3.7202
D-502MG GDSC2 4.2332 8.2488 1.5705 8.6565
CAS-1 GDSC2 4.2363 7.1697 2.0964 5.4652
T98G GDSC2 4.4146 7.9349 1.8503 6.5631
SF539 GDSC2 4.5304 9.0392 1.397 9.0015
GaMG GDSC2 4.5528 8.1088 1.8602 6.2124
D-336MG GDSC2 4.632 8.3556 1.7954 6.4323
Daoy GDSC2 4.6487 6.6116 2.6069 1.8302
AM-38 GDSC2 4.6576 7.6299 2.1532 4.2958
42-MG-BA GDSC2 4.7107 9.472 1.3132 9.0878
KALS-1 GDSC2 4.7117 9.6174 1.2437 9.4868
SK-MG-1 GDSC2 4.7359 7.1123 2.435 2.5985
KS-1 [Human Krukenberg tumour] GDSC2 4.9217 10.1802 1.1171 9.7465
DK-MG GDSC2 4.9294 7.1167 2.5375 1.8126
SW1088 GDSC2 4.9326 7.8225 2.23 3.3983
GB-1 GDSC2 4.95 7.3871 2.4321 2.308
D-423MG GDSC2 4.9869 12.1686 0.1977 14.5125
GI-1 GDSC2 5.0326 7.637 2.368 2.5213
A-172 GDSC2 5.0802 8.6663 1.934 4.7873
M059J GDSC2 5.138 6.8642 2.7393 0.7451
Becker GDSC2 5.1912 7.2484 2.6114 1.1965
Hs 683 GDSC2 5.2078 13.2772 -0.185 15.8506
KINGS-1 GDSC2 5.2169 9.4656 1.6491 6.1417
SW1783 GDSC2 5.2296 7.7225 2.4345 1.943
KNS-81-FD GDSC2 5.2606 12.3223 0.3171 13.2887
PFSK-1 GDSC2 5.3765 7.55 2.5762 1.1718
YH-13 GDSC2 5.411 7.1117 2.7598 0.5057
SNB-75 GDSC2 5.4551 7.6002 2.5918 1.0442
SF268 GDSC2 5.4608 15.1489 -0.9176 18.4722
D-247MG GDSC2 5.4938 7.8581 2.5068 1.3471
D-392MG GDSC2 5.6116 15.6438 -1.0507 18.6694
YKG-1 GDSC2 5.6509 13.1639 0.1806 13.1218
LN-405 GDSC2 5.6585 7.4774 2.7239 0.4799
SF126 GDSC2 5.698 15.1452 -0.7456 17.2329
Onda 11 GDSC2 5.7259 10.8908 1.3039 7.1247
LN-229 GDSC2 5.8955 7.4993 2.8053 0.2125
U-87MG ATCC GDSC2 6.0662 15.5497 -0.6835 16.1838
MOG-G-CCM GDSC2 6.2379 8.5295 2.5676 0.6203
U-251MG GDSC2 6.2544 8.0508 2.744 0.2241
KNS-42 GDSC2 6.9689 15.2457 0.056 11.1636
DBTRG-05MG GDSC2 7.8832 17.4722 -0.4099 11.6537
⏷ Show the Full List of 55 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC1TKB GDSC2 4.0573 5.7272 2.6629 2.4564
ETK-1 GDSC2 4.8358 9.1852 1.5357 7.5313
TGBC24TKB GDSC2 6.0797 7.9967 2.6989 0.3635
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESS-1 GDSC2 3.8904 6.4575 2.199 5.6164
AN3-CA GDSC2 4.0308 6.0964 2.4717 3.6376
MFE-319 GDSC2 4.3523 12.7932 -0.5848 19.7549
MFE-280 GDSC2 4.8747 8.5254 1.8724 5.5074
KLE GDSC2 4.9801 6.9985 2.6126 1.4035
RL95-2 GDSC2 5.4487 7.081 2.7861 0.414
MFE-296 GDSC2 5.5087 7.806 2.5346 1.2217
EN GDSC2 5.7553 17.3724 -1.793 21.1033
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KTCTL-13 GDSC2 2.4348 7.3737 0.5163 20.1291
769-P GDSC2 2.7477 9.2302 -0.1234 22.34
786-O GDSC2 2.7954 6.1755 1.4356 13.534
KTCTL-26A GDSC2 2.9421 6.6493 1.332 13.6912
CAL-54 GDSC2 3.13 5.296 2.1708 7.8659
KTCTL-140 GDSC2 3.3085 6.2403 1.8516 9.3408
LB2241-RCC GDSC2 3.4769 7.0235 1.5986 10.4382
A-498 GDSC2 3.6226 9.0781 0.6905 15.4116
UO-31 GDSC2 3.6473 9.3892 0.555 16.0888
KMRC-20 GDSC2 3.7658 5.3123 2.668 3.0139
NCC010 GDSC2 3.7956 7.7505 1.489 10.2442
LB1047-RCC GDSC2 3.9003 13.2742 -1.1808 23.3995
KTCTL-1M GDSC2 4.0118 7.1236 1.9608 6.7995
BFTC-909 GDSC2 4.1361 6.8402 2.1864 5.1372
ACHN GDSC2 4.1706 8.2443 1.5272 9.0668
TK-10 GDSC2 4.4783 7.2257 2.229 4.1897
A-704 GDSC2 4.5092 12.861 -0.4979 18.9688
KTCTL-195 GDSC2 4.5463 7.2705 2.2508 3.9382
Caki-1 GDSC2 4.5909 10.1778 0.8854 11.7997
BB65-RCC GDSC2 4.6775 9.4922 1.2804 9.3511
NCC021 GDSC2 4.7059 12.8299 -0.3337 17.7354
VMRC-RCW GDSC2 4.9532 9.5615 1.4345 7.873
SW13 GDSC2 5.0187 13.4345 -0.3994 17.2762
SW156 GDSC2 5.1312 9.0371 1.7944 5.4801
HA7-RCC GDSC2 5.136 12.9379 -0.0708 15.4778
KMRC-1 GDSC2 5.3585 7.0734 2.7527 0.5561
VMRC-RCZ GDSC2 5.4226 7.4758 2.6261 0.9415
RCC10RGB GDSC2 5.4792 6.9528 2.8438 0.2645
SN12C GDSC2 5.4885 7.2881 2.7257 0.5636
OS-RC-2 GDSC2 5.6967 7.3601 2.7809 0.323
KTCTL-21 GDSC2 5.8212 18.2215 -2.1615 22.1899
RXF 393L GDSC2 6.0327 11.0536 1.4133 6.0216
LB996-RCC GDSC2 6.305 8.5252 2.5955 0.5161
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LoVo GDSC2 1.3073 6.4338 -0.1197 27.6926
CL-11 GDSC2 2.1298 9.8143 -0.9644 28.0692
HT-29 GDSC2 2.9931 5.9369 1.7312 11.0598
GP5d GDSC2 3.0281 4.6109 2.4188 6.6341
LS1034 GDSC2 3.2852 5.7736 2.0654 8.0613
HCC2998 GDSC2 3.3297 6.6512 1.6638 10.455
SNU-C5 GDSC2 3.3454 7.0305 1.4872 11.5049
HCT 15 GDSC2 3.3548 6.0327 1.9938 8.3106
CCK-81 GDSC2 3.5174 5.8244 2.2296 6.3675
NCI-H508 GDSC2 3.5314 7.1797 1.5647 10.4952
RKO GDSC2 3.5589 6.5151 1.9182 8.2151
SK-CO-1 GDSC2 3.7493 6.897 1.8769 7.9695
MDST8 GDSC2 3.7576 6.4562 2.1015 6.5469
DiFi GDSC2 3.7937 5.906 2.3988 4.6076
SNU-175 GDSC2 3.8062 8.2394 1.2542 11.6362
LS411N GDSC2 3.8736 6.1668 2.3289 4.8527
SW948 GDSC2 3.9647 5.8346 2.5525 3.289
HT115 GDSC2 4.0606 5.7165 2.67 2.4097
T84 GDSC2 4.1079 7.074 2.0537 6.0077
SNU-C1 GDSC2 4.1699 6.496 2.3738 3.9388
HT-55 GDSC2 4.1819 7.2505 2.0199 6.0477
LS513 GDSC2 4.2976 9.5022 1.0024 11.8482
SNU-283 GDSC2 4.3156 10.9213 0.3152 15.5585
CW-2 GDSC2 4.338 7.7469 1.8883 6.5007
LS180 GDSC2 4.4144 8.8403 1.4117 9.1804
NCI-H716 GDSC2 4.4168 7.2717 2.1679 4.6665
KM12 GDSC2 4.5019 8.7774 1.504 8.435
SW1463 GDSC2 4.559 11.3455 0.2887 15.0806
SNU-81 GDSC2 4.5903 8.2804 1.8034 6.471
SNU-C2B GDSC2 4.6717 9.546 1.2504 9.5374
SW620 GDSC2 4.7043 8.6016 1.7262 6.6907
LS123 GDSC2 4.7351 9.2622 1.431 8.3514
COLO 320HSR GDSC2 4.773 8.2289 1.9466 5.2716
C2BBe1 GDSC2 4.7776 7.0808 2.4722 2.3421
SW1417 GDSC2 4.8191 8.2015 1.9883 4.9454
NCI-H747 GDSC2 4.9258 10.0172 1.1983 9.2787
SNU-407 GDSC2 5.049 15.4701 -1.3798 21.2267
COLO205 GDSC2 5.0956 6.3965 2.8969 0.2898
CaR-1 GDSC2 5.2151 8.3102 2.1729 3.2728
SW1116 GDSC2 5.2551 6.9717 2.7482 0.6339
RCM-1 [Human ESC] GDSC2 5.389 6.969 2.8035 0.3963
COLO 678 GDSC2 5.4091 7.8695 2.4621 1.6198
SW837 GDSC2 5.5307 7.5268 2.6532 0.7681
HCT 116 GDSC2 5.6294 7.3158 2.7712 0.3718
SW626 GDSC2 5.6514 7.7727 2.6104 0.8311
⏷ Show the Full List of 45 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC2 3.5677 5.6588 2.3515 5.4658
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hep 3B2.1-7 GDSC2 3.5704 5.9774 2.1952 6.4428
JHH-1 GDSC2 3.7995 5.5864 2.5588 3.6073
JHH-6 GDSC2 3.8412 6.9145 1.9379 7.3565
SK-HEP-1 GDSC2 3.9976 10.3073 0.3751 16.0833
JHH-2 GDSC2 4.0502 6.5399 2.272 4.8041
Hep-G2/C3A GDSC2 4.1965 8.8427 1.2521 10.6455
SNU-387 GDSC2 4.287 9.4068 1.0415 11.6499
SNU-398 GDSC2 4.8705 9.8492 1.2413 9.1526
HuH-1 GDSC2 4.9201 7.5462 2.346 2.7958
HLE GDSC2 4.992 7.6094 2.358 2.6293
Huh-7 GDSC2 5.3558 7.0349 2.766 0.5177
JHH-4 GDSC2 5.6435 7.5579 2.6882 0.5886
SNU-423 GDSC2 6.1539 7.7739 2.803 0.1572
SNU-449 GDSC2 6.2333 12.8289 0.7202 9.2729
JHH-7 GDSC2 6.2527 8.2476 2.6748 0.3542
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 182 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H322M GDSC2 1.261 4.2108 0.78 23.273
NCI-H64 GDSC2 2.0127 4.5166 1.4532 16.2808
NCI-H647 GDSC2 2.1372 5.2205 1.2665 16.8977
NCI-H460 GDSC2 2.7294 7.4086 0.766 17.7317
LB647-SCLC GDSC2 2.8511 6.0457 1.5502 12.6446
NCI-H1703 GDSC2 2.9438 6.0579 1.6273 11.8657
NCI-H82 GDSC2 2.944 5.4419 1.9325 9.9586
NCI-H1944 GDSC2 2.9563 7.6797 0.8313 16.6189
A-427 GDSC2 2.9731 5.1791 2.0888 8.884
NCI-H2122 GDSC2 3.1252 4.8173 2.4046 6.4064
NCI-H2171 GDSC2 3.1315 6.0894 1.7765 10.3434
HCC33 GDSC2 3.1732 15.4178 -2.8504 30.6486
NCI-H847 GDSC2 3.1764 5.3574 2.1805 7.6611
HARA [Human squamous cell lung carcinoma] GDSC2 3.2057 5.0639 2.3522 6.4861
NCI-H838 GDSC2 3.215 8.7147 0.5359 17.4683
LC-1/sq GDSC2 3.2876 9.9392 -0.0153 20.1079
NCI-H1755 GDSC2 3.3659 6.6668 1.686 10.2115
NCI-H1436 GDSC2 3.3677 5.6535 2.194 7.0088
NCI-H292 GDSC2 3.4482 5.9523 2.1104 7.3096
COR-L95 GDSC2 3.4721 8.4914 0.8612 14.8765
CPC-N GDSC2 3.5013 7.2783 1.4912 11.0331
PC-14 GDSC2 3.5154 6.334 1.9739 7.9842
COR-L32 GDSC2 3.5302 5.7979 2.253 6.1858
NCI-H209 GDSC2 3.5358 6.0186 2.1474 6.8358
HCC827 GDSC2 3.5709 7.1432 1.6146 10.0769
SBC-3 GDSC2 3.5737 6.5834 1.896 8.3147
EPLC-272H GDSC2 3.6762 7.1278 1.7056 9.2267
SK-MES-1 GDSC2 3.7051 11.0786 -0.2419 19.9666
COR-L23 GDSC2 3.7313 6.2584 2.1793 6.1265
RERF-LC-MS GDSC2 3.7582 10.7557 -0.0379 18.841
NCI-H2444 GDSC2 3.7619 6.0683 2.296 5.3228
Lu-135 GDSC2 3.7859 6.0869 2.3045 5.2117
SBC-5 GDSC2 3.8049 5.1407 2.7767 2.2747
NCI-H524 GDSC2 3.8058 8.3876 1.1802 12.0784
Lu-65 GDSC2 3.8313 6.9888 1.8937 7.6558
NCI-H1437 GDSC2 3.8911 5.9718 2.4362 4.1535
COR-L303 GDSC2 3.9154 6.4144 2.238 5.3166
NCI-H2196 GDSC2 3.9469 9.0261 0.9725 12.9181
NCI-H2170 GDSC2 3.9509 6.2347 2.3506 4.5436
NCI-H290 GDSC2 3.9602 6.0958 2.4241 4.0745
LCLC-97TM1 GDSC2 3.9642 9.0476 0.9751 12.8576
IST-SL1 GDSC2 3.9696 6.9342 2.023 6.5164
BEN GDSC2 3.9856 10.0781 0.4798 15.56
SK-LU-1 GDSC2 4.0191 9.9155 0.5866 14.8931
IST-SL2 GDSC2 4.0577 6.4133 2.3381 4.3861
NCI-H720 GDSC2 4.0772 6.0865 2.507 3.3325
NCI-H250 GDSC2 4.0773 6.0271 2.5352 3.1656
NCI-H748 GDSC2 4.0965 7.2262 1.9716 6.5355
Ms-1 GDSC2 4.1103 5.8074 2.6586 2.3853
NCI-H520 GDSC2 4.1225 7.2272 1.9896 6.3663
LCLC-103H GDSC2 4.1351 7.2542 1.9854 6.3631
COR-L279 GDSC2 4.1406 8.8448 1.2095 11.0359
NCI-H1341 GDSC2 4.2045 7.1908 2.0644 5.7276
NCI-H23 GDSC2 4.2106 6.9844 2.1679 5.0887
NCI-H345 GDSC2 4.2476 6.5337 2.4064 3.5931
DMS 79 GDSC2 4.2486 6.2894 2.521 2.9255
NCI-H146 GDSC2 4.2671 7.1432 2.13 5.1976
NCI-H1975 GDSC2 4.3117 8.7646 1.3749 9.6396
A-549 GDSC2 4.3201 9.4923 1.0239 11.6693
Calu-6 GDSC2 4.3308 8.4013 1.5661 8.4548
NCI-H1792 GDSC2 4.3469 6.3973 2.5312 2.6944
NCI-H69 GDSC2 4.3606 6.7882 2.359 3.6552
NCI-H1836 GDSC2 4.3611 6.8709 2.3207 3.8773
NCI-H2110 GDSC2 4.3625 7.1878 2.1722 4.749
NCI-H358 GDSC2 4.3921 8.2008 1.7066 7.4734
NCI-H727 GDSC2 4.3958 7.786 1.909 6.2512
NCI-H740 GDSC2 4.4226 11.9896 -0.1323 17.5085
NCI-H211 GDSC2 4.4389 7.4533 2.0965 5.0449
CAL-12T GDSC2 4.4914 19.2008 -3.6652 29.2943
HOP-62 GDSC2 4.4958 7.2145 2.2453 4.0628
NCI-H810 GDSC2 4.4992 6.4211 2.6086 2.0306
LC-2/ad GDSC2 4.514 6.7615 2.4648 2.7855
NCI-H1568 GDSC2 4.5471 9.7362 1.0696 10.8621
NCI-H1435 GDSC2 4.5689 7.0753 2.3545 3.3084
NCI-H1993 GDSC2 4.6063 12.3355 -0.1644 17.1958
NCI-H2023 GDSC2 4.6114 12.1652 -0.0764 16.7639
Lu-165 GDSC2 4.6325 6.9673 2.4409 2.726
NCI-H2731 GDSC2 4.6552 8.9726 1.5157 8.0291
NCI-H510A GDSC2 4.6725 6.7152 2.5747 1.9612
COR-L321 GDSC2 4.6737 6.4758 2.6781 1.4482
SBC-1 GDSC2 4.6743 11.3574 0.368 14.3891
ChaGo-K-1 GDSC2 4.6832 6.9647 2.4709 2.487
NCI-H1838 GDSC2 4.6836 7.7735 2.1027 4.5382
SW1271 GDSC2 4.6967 7.4901 2.2416 3.7239
NCI-H2810 GDSC2 4.7018 8.542 1.7529 6.5392
NCI-H446 GDSC2 4.7405 6.5302 2.6889 1.32
HCC44 GDSC2 4.764 9.0425 1.5558 7.563
NCI-H2795 GDSC2 4.8161 7.5558 2.2824 3.2981
NCI-H2085 GDSC2 4.8167 6.8967 2.5729 1.7808
NCI-H226 GDSC2 4.846 6.1991 2.8697 0.4995
NCI-H2818 GDSC2 4.8508 9.975 1.1672 9.6173
NCI-H841 GDSC2 4.858 15.2053 -1.3932 21.7341
NCI-H1651 GDSC2 4.8639 6.8766 2.6056 1.5663
NCI-H1105 GDSC2 4.9033 7.5482 2.3357 2.8753
NCI-H3255 GDSC2 4.9207 10.7229 0.8543 11.2123
NCI-H2087 GDSC2 4.9303 7.5867 2.3338 2.8452
UMC-11 GDSC2 4.97 6.9966 2.6084 1.4333
NCI-H1623 GDSC2 4.9797 14.5152 -0.9604 19.7654
HOP-92 GDSC2 4.9845 7.2335 2.5162 1.8475
DMS 53 GDSC2 4.985 7.0815 2.5805 1.5443
NCI-H596 GDSC2 5.0531 7.2587 2.5404 1.6523
NCI-H2029 GDSC2 5.0786 7.7237 2.3551 2.5239
NCI-H1092 GDSC2 5.0962 6.5148 2.8541 0.4022
NCI-H650 GDSC2 5.0989 6.8602 2.7238 0.8319
COR-L311 GDSC2 5.0993 6.8778 2.717 0.857
Lu-134-A GDSC2 5.1133 19.9175 -3.5343 27.5888
NCI-H1048 GDSC2 5.1237 6.5946 2.8356 0.4406
DMS 273 GDSC2 5.1282 6.8944 2.7234 0.8105
Lu-139 GDSC2 5.1398 15.173 -1.1653 20.1974
NCI-H2141 GDSC2 5.1701 8.3208 2.1429 3.4987
NCI-H522 GDSC2 5.1853 7.8442 2.3599 2.3585
NCI-H1693 GDSC2 5.1992 12.7929 0.0451 14.7748
NCI-H2869 GDSC2 5.2097 10.1528 1.3225 7.9918
NCI-H1770 GDSC2 5.2108 6.9275 2.7463 0.6695
LK-2 GDSC2 5.2352 7.6621 2.4627 1.8053
Calu-3 GDSC2 5.2465 7.0824 2.702 0.7986
NCI-H1781 GDSC2 5.2486 7.5823 2.5025 1.6094
NCI-H526 GDSC2 5.251 6.6473 2.8663 0.2993
RERF-LC-KJ GDSC2 5.2528 7.1212 2.6897 0.8384
NCI-H1793 GDSC2 5.2719 13.7067 -0.3487 16.4564
EMC-BAC-2 GDSC2 5.2907 7.8985 2.3914 2.075
EBC-1 GDSC2 5.3023 9.6889 1.5985 6.2692
NCI-H1155 GDSC2 5.314 6.9129 2.7943 0.458
COR-L88 GDSC2 5.3169 7.2765 2.6574 0.908
KNS-62 GDSC2 5.3319 6.8133 2.8377 0.3348
ABC-1 GDSC2 5.3751 13.3442 -0.0983 15.0643
LXF 289 GDSC2 5.3755 7.2571 2.6903 0.7477
NCI-H441 GDSC2 5.3845 8.7077 2.0916 3.4505
NCI-H1876 GDSC2 5.392 7.2637 2.6948 0.7212
NCI-H196 GDSC2 5.3965 6.961 2.8093 0.3777
HCC366 GDSC2 5.4198 15.0389 -0.8935 18.4663
NCI-H2342 GDSC2 5.4288 14.241 -0.4969 16.7616
NCI-H1915 GDSC2 5.4362 12.9286 0.1461 13.7524
COLO 668 GDSC2 5.4461 7.6754 2.558 1.1831
NCI-H2804 GDSC2 5.4689 14.8346 -0.758 17.7937
NCI-H2722 GDSC2 5.4766 7.2653 2.7293 0.5594
EKVX GDSC2 5.4871 11.0984 1.0561 8.9162
NCI-H2291 GDSC2 5.4887 7.5743 2.6168 0.9252
NCI-H2373 GDSC2 5.4929 7.4236 2.6765 0.7155
NCI-H2066 GDSC2 5.493 9.2745 1.9011 4.2919
IA-LM GDSC2 5.5111 7.1477 2.7862 0.3853
NCI-H2803 GDSC2 5.5686 7.2079 2.7866 0.3598
NCI-H1688 GDSC2 5.5772 7.2792 2.7642 0.4117
EMC-BAC-1 GDSC2 5.6026 8.0709 2.4718 1.3906
NCI-H1734 GDSC2 5.6113 7.6272 2.6489 0.7296
NCI-H1573 GDSC2 5.6219 7.3551 2.7541 0.4175
VMRC-LCD GDSC2 5.6929 15.0121 -0.6844 16.9858
HCC78 GDSC2 5.7169 7.2752 2.8183 0.239
NCI-H2030 GDSC2 5.7279 12.015 0.7798 9.919
NCI-H2172 GDSC2 5.7335 7.0752 2.8928 0.1169
NCI-H661 GDSC2 5.7475 7.6029 2.7131 0.4661
DMS 114 GDSC2 5.7527 7.202 2.8565 0.1641
NCI-H2591 GDSC2 5.783 9.1419 2.1167 2.7911
NCI-H2228 GDSC2 5.7942 7.8455 2.6424 0.6406
NCI-H2135 GDSC2 5.7955 7.5367 2.7554 0.3431
NCI-H2009 GDSC2 5.8359 17.7482 -1.9185 21.3571
NCI-H2461 GDSC2 5.8375 13.1377 0.319 12.0523
NCI-H2227 GDSC2 5.8882 26.335 -6.1221 31.1464
NCI-H2369 GDSC2 5.909 7.5364 2.7974 0.2226
NCI-H1563 GDSC2 5.9259 7.2405 2.9034 0.0768
NCI-H2405 GDSC2 5.9369 15.3536 -0.6786 16.4355
NCI-H513 GDSC2 5.9405 7.5584 2.8011 0.208
NCI-H1581 GDSC2 5.9406 17.3917 -1.6679 20.2667
NCI-H1650 GDSC2 5.9604 7.7714 2.734 0.3301
PaCa-3 GDSC2 5.985 7.9418 2.6825 0.4383
NCI-H1666 GDSC2 6.0086 7.7801 2.7488 0.2839
NCI-H1648 GDSC2 6.0118 8.4782 2.4939 0.9815
Lu-99A GDSC2 6.0331 8.0891 2.6479 0.5042
NCI-H835 GDSC2 6.089 8.5518 2.4985 0.9143
NCI-H2347 GDSC2 6.0952 8.1564 2.6476 0.4773
NCI-H2081 GDSC2 6.0954 8.2212 2.6242 0.5372
LOU-NH91 GDSC2 6.1076 17.2899 -1.4986 19.3039
NCI-H3122 GDSC2 6.1439 8.6279 2.4927 0.8981
NCI-H1869 GDSC2 6.164 8.1155 2.6884 0.3561
SW1573 GDSC2 6.3577 8.705 2.5507 0.6077
HCC15 GDSC2 6.3725 8.1517 2.7514 0.1857
NCI-H2595 GDSC2 6.4005 8.4555 2.6564 0.3427
COR-L105 GDSC2 6.5803 8.8977 2.5671 0.4712
NCI-H1355 GDSC2 6.6228 19.3233 -2.1227 20.4087
RERF-LC-Sq1 GDSC2 6.7344 8.9254 2.6146 0.3214
NCI-H1299 GDSC2 7.3507 20.2198 -2.051 18.7786
SHP-77 GDSC2 7.4583 23.7962 -3.7063 23.3813
⏷ Show the Full List of 182 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC2 5.5493 8.2558 2.3711 1.8758
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-140 GDSC2 1.3071 4.7071 0.635 23.8636
TE-10 GDSC2 2.3644 4.0845 2.002 11.6358
TE-11 GDSC2 3.0246 6.9767 1.2413 13.9808
OE33 GDSC2 3.3753 6.9333 1.5606 10.9643
KYSE-180 GDSC2 3.4231 7.7898 1.1717 13.1971
OE21 GDSC2 3.432 6.2362 1.9555 8.3319
KYSE-150 GDSC2 3.9011 7.7691 1.5607 9.5325
TE-6 GDSC2 4.133 7.2101 2.0053 6.2464
KYSE-270 GDSC2 4.148 7.7334 1.761 7.7029
KYSE-410 GDSC2 4.3788 7.2516 2.1527 4.8322
COLO 680N GDSC2 4.5894 6.3338 2.695 1.4697
EC-GI-10 GDSC2 4.6635 9.4985 1.2676 9.4563
TE-15 GDSC2 4.7425 10.7818 0.6994 12.467
KYSE-520 GDSC2 4.9373 7.237 2.4902 2.0336
TE-9 GDSC2 4.9676 6.4316 2.8325 0.543
KYSE-450 GDSC2 5.1963 7.1362 2.6587 1.0014
TE-1 GDSC2 5.4704 7.8743 2.4894 1.4414
OE19 GDSC2 5.4887 6.6953 2.936 0.1055
TE-5 GDSC2 5.6056 7.528 2.6839 0.6229
T.T GDSC2 6.0213 7.6897 2.7848 0.2148
TE-4 GDSC2 6.2212 7.9658 2.7613 0.2042
KYSE-70 GDSC2 6.3663 8.5161 2.6222 0.4277
KYSE-510 GDSC2 6.9811 16.0142 -0.2955 12.7198
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHOS-4 GDSC2 2.3602 7.3409 0.4638 20.6768
IGROV-1 GDSC2 2.903 5.7599 1.7383 11.3062
OC 314 GDSC2 3.352 5.7002 2.1578 7.2826
Caov-4 GDSC2 3.5239 5.8663 2.2139 6.4494
DOV13 GDSC2 3.5547 7.7373 1.3051 12.0187
OVK18 GDSC2 3.5922 9.504 0.4532 16.7978
Caov-3 GDSC2 3.8094 7.2559 1.7449 8.6342
ES-2 GDSC2 3.8714 8.6254 1.113 12.3
TOV-21G GDSC2 4.0043 7.8793 1.5839 9.1301
SK-OV-3 GDSC2 4.0282 6.1706 2.4345 3.8664
FU-OV-1 GDSC2 4.197 9.495 0.9309 12.5088
TYK-nu GDSC2 4.2093 9.4292 0.9726 12.2395
A2780 GDSC2 4.4423 6.4843 2.548 2.4435
OVCAR-4 GDSC2 4.5408 12.4691 -0.2799 17.9008
OVCAR-8 GDSC2 4.5775 7.3587 2.2293 4.0048
TOV-112D GDSC2 4.6993 15.299 -1.561 22.7316
OVTOKO GDSC2 4.7349 7.2031 2.394 2.8197
OAW42 GDSC2 4.7882 6.0735 2.8931 0.4601
Kuramochi GDSC2 4.7897 8.0777 2.0276 4.7746
OVCAR-3 GDSC2 4.9224 10.6788 0.8769 11.0839
OV56 GDSC2 5.0495 6.3583 2.8929 0.3201
EFO-27 GDSC2 5.0828 15.2407 -1.2411 20.624
RMG-I GDSC2 5.1561 8.2555 2.164 3.4073
OVISE GDSC2 5.1671 7.328 2.5677 1.4065
JHOS-2 GDSC2 5.5251 7.0189 2.8375 0.2619
OAW28 GDSC2 5.6076 10.7566 1.2929 7.3978
OVKATE GDSC2 5.6494 7.36 2.763 0.3835
EFO-21 GDSC2 5.7919 7.3575 2.817 0.2199
OVCAR-5 GDSC2 5.9004 7.6175 2.766 0.2841
OV-90 GDSC2 8.5616 20.6083 -1.4426 14.5686
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Panc 03.27 GDSC2 3.541 5.1729 2.5721 4.1477
DAN-G GDSC2 3.6408 5.2342 2.6167 3.6191
BxPC-3 GDSC2 3.6755 6.9168 1.81 8.5792
PL4 GDSC2 3.7007 7.0867 1.7452 8.9161
Panc 04.03 GDSC2 4.2036 6.3237 2.4768 3.2649
QGP-1 GDSC2 4.4583 9.2054 1.265 9.941
AsPC-1 GDSC2 4.5271 9.5981 1.1228 10.6042
PaTu 8988t GDSC2 4.5587 5.7758 2.909 0.5662
MIA PaCa-2 GDSC2 4.6576 7.5292 2.1998 4.0291
SUIT-2 GDSC2 4.6718 6.3065 2.748 1.1271
YAPC GDSC2 4.6898 6.3247 2.7492 1.1023
MZ-PC-1 GDSC2 4.7518 8.0456 2.0188 4.895
SW1990 GDSC2 4.9475 7.3243 2.458 2.1806
KP-3 GDSC2 4.948 9.8588 1.2891 8.715
HPAC GDSC2 5.0814 8.2999 2.1013 3.8612
Panc 02.03 GDSC2 5.108 9.4202 1.6017 6.6123
PaTu 8902 GDSC2 5.1838 6.7249 2.8115 0.4785
PSN1 GDSC2 5.2141 8.9159 1.9003 4.7461
Capan-2 GDSC2 5.278 10.4442 1.2293 8.377
Panc 08.13 GDSC2 5.3126 7.8077 2.4405 1.8205
KP-4 GDSC2 5.4002 6.8226 2.8603 0.2569
KP-1N GDSC2 5.5197 7.9207 2.4937 1.377
HuP-T3 GDSC2 5.5974 7.5624 2.6676 0.6784
Capan-1 GDSC2 5.62 7.3031 2.7722 0.3734
SU.86.86 GDSC2 5.7102 6.9464 2.9279 0.0804
KP-2 GDSC2 5.7499 12.2904 0.6639 10.4799
CFPAC-1 GDSC2 5.8669 7.6462 2.7433 0.3435
Panc 10.05 GDSC2 6.0321 7.7796 2.7576 0.2601
HuP-T4 GDSC2 6.0399 7.5869 2.8266 0.1472
HPAF-II GDSC2 6.2415 8.2316 2.6763 0.3549
Hs 766T GDSC2 7.0736 17.5275 -0.9502 15.2885
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MPP 89 GDSC2 4.5756 6.5217 2.6065 1.9322
NCI-H2452 GDSC2 4.6378 13.0437 -0.4906 18.6121
NCI-H28 GDSC2 5.468 9.4706 1.7984 4.8827
NCI-H2052 GDSC2 5.5823 7.4823 2.6914 0.6134
MSTO-211H GDSC2 5.7472 8.1962 2.4878 1.2023
IST-Mes1 GDSC2 7.2362 19.2039 -1.6414 17.585
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC GDSC2 3.4971 9.2264 0.5143 16.7432
VCaP GDSC2 4.7425 9.4286 1.3561 8.7698
PC-3 GDSC2 5.0004 7.6235 2.3564 2.6258
DU145 GDSC2 5.3686 7.6851 2.5181 1.4188
NCI-H660 GDSC2 5.4013 6.8943 2.8352 0.3124
22Rv1 GDSC2 5.5979 8.1824 2.4246 1.592
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC2 4.1687 6.1668 2.5281 3.0317
Cancer Drug Sensitivity Data Curated from 57 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 783 GDSC2 2.7098 6.7586 1.0701 16.0278
HT-144 GDSC2 2.7762 8.3878 0.321 20.0154
RPMI-7951 GDSC2 3.3334 6.5026 1.7411 9.9615
DJM-1 GDSC2 3.4587 7.2048 1.4933 11.1407
G-mel GDSC2 3.4994 7.5558 1.351 11.8964
WM793 GDSC2 3.5079 5.0422 2.6114 3.986
HMV-II GDSC2 3.7565 8.2468 1.2116 12.0243
VMRC-MELG GDSC2 3.7822 6.6524 2.023 6.9745
IST-MEL1 GDSC2 3.9035 10.0503 0.4293 16.0528
M14 GDSC2 3.9422 7.6332 1.6589 8.8273
IPC-298 GDSC2 3.9552 10.7559 0.1186 17.5184
MeWo GDSC2 3.969 7.4445 1.7719 8.0663
SK-MEL-24 GDSC2 3.9754 11.8143 -0.3927 19.9068
COLO 829 GDSC2 3.9852 11.7168 -0.3364 19.6228
MZ-MEL-2 GDSC2 4.0722 6.3425 2.3819 4.0909
WM1552C GDSC2 4.082 6.1943 2.4591 3.6078
CP50-MEL-B GDSC2 4.0977 8.1005 1.5443 9.1405
RVH-421 GDSC2 4.1416 6.8071 2.2061 5.0058
SH-4 GDSC2 4.1927 8.0303 1.6481 8.2834
SK-MEL-3 GDSC2 4.1961 6.1667 2.5453 2.8812
SK-MEL-5 GDSC2 4.2396 8.1298 1.6332 8.2629
Mel Ho GDSC2 4.2433 7.0255 2.1703 5.0056
Hs 938.T GDSC2 4.27 7.1449 2.1312 5.1843
GAK GDSC2 4.3476 6.0841 2.673 1.915
MZ-MEL-7 GDSC2 4.4291 9.0186 1.3353 9.5975
COLO 679 GDSC2 4.4589 7.3179 2.1734 4.5517
SK-MEL-2 GDSC2 4.5081 5.8883 2.8407 0.8881
IGR-37 GDSC2 4.5097 8.7834 1.5066 8.4024
Mel JuSo GDSC2 4.5709 6.827 2.4683 2.6741
IGR-1 GDSC2 4.6421 14.3295 -1.1241 21.2417
COLO 800 GDSC2 4.65 11.4919 0.284 14.8803
COLO 792 GDSC2 4.6971 8.3058 1.8617 5.9116
A-431 GDSC2 4.6976 9.8688 1.112 10.2728
A2058 GDSC2 4.7237 5.837 2.955 0.3101
A-375 GDSC2 4.7596 9.5063 1.3303 8.8818
SK-MEL-30 GDSC2 4.9011 19.0336 -3.2598 27.3794
451Lu GDSC2 4.9055 7.3764 2.4127 2.4687
LB2518-MEL GDSC2 4.98 6.6133 2.7678 0.7614
A-388 GDSC2 4.9901 8.2247 2.0817 4.1187
CP66-MEL GDSC2 5.078 6.4629 2.8659 0.3784
LB373-MEL-D GDSC2 5.1156 7.6066 2.4252 2.1262
LOX-IMVI GDSC2 5.12 18.3594 -2.7559 25.5342
CHL-1 GDSC2 5.1518 14.269 -0.7116 18.3264
UACC-257 GDSC2 5.1833 6.9522 2.725 0.7631
Hs 940.T GDSC2 5.213 14.4763 -0.7685 18.4236
G-361 GDSC2 5.2586 11.0041 0.9503 9.9553
SK-MEL-1 GDSC2 5.2723 6.6448 2.8753 0.2702
WM115 GDSC2 5.289 6.6693 2.8729 0.2694
MMAc-SF GDSC2 5.3609 7.1692 2.7176 0.6658
A101D GDSC2 5.3866 9.4058 1.7798 5.1186
WM35 GDSC2 5.4158 10.3081 1.3815 7.2665
WM278 GDSC2 5.441 13.2512 -0.0068 14.4826
WT2-iPS GDSC2 5.4511 12.707 0.2635 13.1399
SK-MEL-31 GDSC2 5.4707 11.1494 1.0214 9.1369
SK-MEL-28 GDSC2 6.1354 21.9647 -3.7712 26.032
UACC-62 GDSC2 8.6055 29.6003 -5.7167 25.8715
EquiPSC Line K2 GDSC2 3.9926 8.9008 1.0698 12.2336
⏷ Show the Full List of 57 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC2 3.2437 5.1123 2.3608 6.3167
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Rh30 GDSC2 3.1075 4.2089 2.6891 4.677
Hs 633.T GDSC2 3.3316 5.4919 2.245 6.7904
G-402 GDSC2 3.4682 6.1479 2.0289 7.7681
STS-0421 GDSC2 3.5102 8.3977 0.9392 14.3165
SW982 GDSC2 3.554 10.4172 -0.0342 19.4086
TE 441.T GDSC2 3.5967 6.6003 1.9058 8.191
EW-8 GDSC2 3.9585 6.386 2.2825 4.9437
KYM-1 GDSC2 4.0131 9.5917 0.7428 14.0471
Rh41 GDSC2 4.1416 7.5708 1.8358 7.2618
MES-SA GDSC2 4.2431 6.9036 2.2284 4.6572
GCT GDSC2 4.3968 7.5622 2.0168 5.6043
HT-1080 GDSC2 4.4466 6.1684 2.6906 1.6794
SW684 GDSC2 4.825 5.8019 3.0062 0.1493
SK-UT-1 GDSC2 5.1803 13.7194 -0.4211 16.9942
VA-ES-BJ GDSC2 5.4424 7.2852 2.7078 0.6461
RKN GDSC2 5.7083 7.2029 2.8403 0.2014
A-204 GDSC2 5.7792 13.8191 -0.0468 13.9433
SW872 GDSC2 5.9053 7.5729 2.7834 0.249
SK-LMS-1 GDSC2 5.9692 7.6163 2.7914 0.217
MFH-ino GDSC2 6.028 8.3516 2.5488 0.791
RD GDSC2 6.0611 8.2412 2.6033 0.6107
G-401 GDSC2 6.8875 9.0045 2.6423 0.236
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-39 GDSC2 1.4233 5.1878 0.5546 23.8041
TGBC11TKB GDSC2 1.9641 5.8216 0.8163 20.18
MKN7 GDSC2 2.7022 12.3111 -1.699 28.743
23132/87 GDSC2 3.1206 5.806 1.9083 9.5491
SCH GDSC2 3.1478 7.1961 1.2378 13.6197
OCUM-1 GDSC2 3.318 7.9718 0.9937 14.5603
MKN1 GDSC2 3.3858 8.2427 0.9146 14.821
SNU-5 GDSC2 3.5572 6.897 1.7265 9.4192
ECC12 GDSC2 3.6649 5.6592 2.4254 4.7539
NUGC-3 GDSC2 3.6873 6.5227 2.0149 7.2676
SNU-1 GDSC2 3.7756 6.4757 2.1053 6.4775
AGS GDSC2 3.8791 9.2051 0.8308 13.9109
NCI-N87 GDSC2 3.9537 7.7924 1.5889 9.2267
KATO III GDSC2 4.0243 7.4161 1.8266 7.5952
GCIY GDSC2 4.0826 6.5492 2.2898 4.6255
MKN45 GDSC2 4.1038 14.4385 -1.5989 24.381
MKN28 GDSC2 4.2006 6.6898 2.302 4.3047
SK-GT-2 GDSC2 4.2928 7.8915 1.787 7.2117
Hs 746.T GDSC2 4.6225 11.1373 0.4381 14.1496
NUGC-4 GDSC2 4.629 8.3053 1.8173 6.3093
Fu97 GDSC2 4.8868 6.9607 2.5818 1.6518
TMK-1 GDSC2 5.094 8.1073 2.1949 3.3373
RF-48 GDSC2 5.1419 12.1971 0.2945 13.6692
ECC10 GDSC2 5.7704 7.5441 2.7431 0.3812
HGC-27 GDSC2 5.9964 14.3832 -0.1698 14.063
RERF-GC-1B GDSC2 6.0087 8.4121 2.5178 0.9029
IM95 GDSC2 6.2252 8.0459 2.7352 0.2465
SNG-M GDSC2 3.4623 8.3029 0.9474 14.4071
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IHH-4 GDSC2 3.4218 7.0818 1.5245 11.0536
K5 GDSC2 3.6828 8.6945 0.9302 13.8802
B-CPAP GDSC2 4.0823 8.8225 1.1767 11.3762
TT GDSC2 4.2559 6.986 2.1976 4.8155
KMH-2 GDSC2 4.2592 7.2337 2.0813 5.5074
ML-1 [Human leukemia] GDSC2 4.308 9.5585 0.9824 11.9371
CAL-62 GDSC2 4.678 13.6271 -0.7488 19.6291
HTC-C3 GDSC2 5.1646 11.4686 0.6632 11.7048
TT2609-C02 GDSC2 5.1712 8.3865 2.1142 3.6505
WRO GDSC2 5.2829 6.7432 2.8441 0.3401
BHT-101 GDSC2 5.3577 10.4746 1.2665 8.014
CGTH-W-1 GDSC2 5.5272 6.8438 2.8991 0.1497
ASH-3 GDSC2 5.7421 7.2266 2.8443 0.1861
8305C GDSC2 5.8085 15.0148 -0.6043 16.3928
8505C GDSC2 6.0424 7.7265 2.7797 0.218
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PCI-06A GDSC2 1.5458 7.4234 -0.3477 27.7431
Ca9-22 GDSC2 1.5632 8.1173 -0.6628 29.0025
KON GDSC2 2.0545 4.89 1.333 16.8232
PCI-15A GDSC2 3.1345 9.3477 0.1515 19.7451
KOSC-2 GDSC2 3.2241 5.0372 2.3815 6.2447
JHU-011 GDSC2 3.2255 5.0476 2.3774 6.2664
BICR 10 GDSC2 3.4374 7.3422 1.4072 11.7306
HSC-3 GDSC2 3.4621 8.2142 0.9916 14.1502
DOK GDSC2 3.7196 6.5122 2.0449 6.9972
Detroit 562 GDSC2 3.7349 9.4503 0.5948 15.6245
HO-1-u-1 GDSC2 3.7921 7.9275 1.3983 10.8059
BB49-HNC GDSC2 3.9639 6.7889 2.09 6.1167
BICR 31 GDSC2 3.9796 9.2535 0.8848 13.3349
PCI-04B GDSC2 3.9848 10.0885 0.474 15.5934
CAL-27 GDSC2 4.0865 13.2041 -0.9973 22.1789
HSC-2 GDSC2 4.3726 14.0719 -1.2045 22.2363
HO-1-N-1 GDSC2 4.3798 6.582 2.4664 3.0036
HSC-4 GDSC2 4.4249 8.5222 1.5737 8.1943
CAL-33 GDSC2 4.462 7.7399 1.9756 5.715
SAS GDSC2 4.4633 11.1577 0.3098 15.2107
NCI-H3118 GDSC2 4.5343 7.5351 2.1197 4.7207
JHU-029 GDSC2 4.6322 8.3031 1.8204 6.2846
BICR 78 GDSC2 4.6673 9.8572 1.0963 10.4309
BICR 22 GDSC2 4.7784 8.7092 1.724 6.5534
SKN-3 GDSC2 4.7884 8.8179 1.679 6.7952
JHU-022 GDSC2 4.8335 7.9659 2.1061 4.2498
OSC-20 GDSC2 4.8545 7.6788 2.2493 3.4175
SAT [Human HNSCC] GDSC2 5.1462 17.9327 -2.5244 24.805
BB30-HNC GDSC2 5.2076 12.0144 0.4292 12.8341
OSC-19 GDSC2 5.3634 7.2796 2.6764 0.8043
UPCI-SCC-090 GDSC2 5.407 8.0143 2.4012 1.8951
SCC-4 GDSC2 5.413 7.0083 2.7985 0.398
BHY GDSC2 5.4394 13.2189 0.0077 14.4167
PE/CA-PJ15 GDSC2 5.5301 7.2698 2.7491 0.4742
LB771-HNC GDSC2 5.6204 7.7181 2.6182 0.8258
SCC-15 GDSC2 5.6648 7.9514 2.5472 1.045
SCC-9 GDSC2 5.8733 7.5587 2.7766 0.2717
PCI-30 GDSC2 5.9162 12.3249 0.7552 9.683
SCC-25 GDSC2 5.9358 8.3365 2.5158 0.9589
FaDu GDSC2 7.3717 21.9405 -2.8665 21.2689
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KU-19-19 GDSC2 3.5089 5.3704 2.449 5.0068
CAL-29 GDSC2 3.5438 5.7421 2.2914 5.9075
RT-112 GDSC2 3.5518 4.7931 2.768 2.8931
639V GDSC2 3.8783 5.7192 2.5493 3.4911
5637 GDSC2 4.0889 7.2797 1.9401 6.7463
SW780 GDSC2 4.1108 6.0924 2.526 3.1541
BFTC-905 GDSC2 4.2784 9.4352 1.0212 11.7879
HT-1376 GDSC2 5.3071 12.6961 0.1684 13.9279
RT-4 GDSC2 5.348 7.3696 2.6347 0.9683
647V GDSC2 5.3973 6.9561 2.8114 0.372
TCCSUP GDSC2 5.4568 7.7024 2.5521 1.1973
T24 GDSC2 5.8501 8.868 2.265 2.0288
SW1710 GDSC2 5.9046 7.7018 2.7378 0.3419
J82 GDSC2 6.1773 8.4248 2.5821 0.6108
HT-1197 GDSC2 7.0618 19.8299 -2.0614 19.3547
UM-UC-3 GDSC2 8.1589 18.8666 -0.8845 13.127
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UWB1.289 GDSC2 2.3607 5.7881 1.2183 16.356
JAR GDSC2 3.2744 7.5332 1.1766 13.6055
NEC8 GDSC2 3.3595 8.5665 0.7309 15.9495
C-4-I GDSC2 3.4201 5.914 2.1068 7.4115
CAL-39 GDSC2 3.5689 6.2431 2.0617 7.2864
SW954 GDSC2 3.6903 8.0427 1.2611 11.9083
OV17R GDSC2 3.7425 7.1339 1.7541 8.751
Ca Ski GDSC2 3.7684 7.1705 1.7559 8.6723
HeLa GDSC2 3.8122 5.4508 2.6332 3.1246
PEO1 GDSC2 3.8372 6.3404 2.2176 5.628
HEC-1 GDSC2 3.86 5.5949 2.5966 3.2439
TC-YIK GDSC2 4.0054 6.6815 2.1721 5.515
PA-1 GDSC2 4.1284 8.8679 1.189 11.1872
OMC-1 [Human cervical carcinoma] GDSC2 4.1437 7.7628 1.7435 7.8191
ACC-OV7 GDSC2 4.1995 10.2364 0.5661 14.53
PWR-1E GDSC2 4.3035 10.849 0.3419 15.4514
JEG-3 GDSC2 4.3757 12.825 -0.5825 19.6843
DSH1 GDSC2 4.3944 7.083 2.2424 4.2722
NCC-IT GDSC2 4.6145 10.3614 0.8127 12.1484
BPH-1 GDSC2 4.7478 7.2458 2.3823 2.8633
SiHa GDSC2 4.7808 6.1526 2.8597 0.5779
DoTc2 4510 GDSC2 4.8185 9.0517 1.5877 7.2649
JHOS-3 GDSC2 4.837 16.5436 -2.0726 24.1314
MS751 GDSC2 4.919 6.9708 2.5938 1.5574
HT-3 GDSC2 4.9285 8.4714 1.931 5.0728
SW962 GDSC2 4.9911 8.3317 2.0336 4.3848
HEY GDSC2 5.0086 7.2112 2.538 1.7149
OVCA420 GDSC2 5.0196 6.9257 2.6614 1.1505
OVMIU GDSC2 5.2117 7.727 2.4236 2.0162
KGN GDSC2 5.2284 7.329 2.5963 1.2243
NT2-D1 GDSC2 5.358 6.944 2.8004 0.4191
SW756 GDSC2 5.5432 7.3327 2.7312 0.5178
SiSo GDSC2 5.5972 7.5985 2.6539 0.7224
SKN GDSC2 5.8764 7.5859 2.7682 0.2875
LB831-BLC GDSC2 6.0379 8.0059 2.6798 0.4231
C-33 A GDSC2 6.0751 8.2556 2.6036 0.6027
OVCA433 GDSC2 6.1688 19.2504 -2.4123 22.2488
ME-180 GDSC2 6.2498 8.4025 2.6185 0.4831
SKG-IIIa GDSC2 7.0583 17.4047 -0.9019 15.1241
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8042).
2 ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses. Cancer Res. 2014 Dec 1;74(23):6968-79.