Details of the Drug

General Information of Drug (ID: DM0WD1V)

Drug Name
Human calcitonin
Synonyms Calcitonin (human synthetic); Calcitonin (human); Calcitonin human; Calcitonin, human; Calcitonin, human synthetic
Affected Organisms
Humans and other mammals
ATC Code
H05BA03: Human calcitonin
H05BA: Calcitonin preparations
H05B: ANTI-PARATHYROID AGENTS
H05: CALCIUM HOMEOSTASIS
H: SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
Sequence
CGNLSTCMLGTYTQDFNKFHTFPQTAIGVGAP
Structure
3D MOL is unavailable 2D MOL
ADMET Property
Absorption Cmax
The maximum plasma concentration (Cmax) of drug is 1.3 mg/L []
Absorption Tmax
The time to maximum plasma concentration (Tmax) is 4 h []
Bioavailability
The bioavailability of drug is 57% []
Clearance
The renal clearance of drug is 1.96 mL/min [1]
Half-life
The concentration or amount of drug in body reduced by one-half in 10.2 - 37.8 minutes [2]
Metabolism
The drug is metabolized via the kidney [3]
Cross-matching ID
PubChem CID
16220016
UNII
I0IO929019
DrugBank ID
DB06773
INTEDE ID
DR0811

Molecular Interaction Atlas of This Drug


Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Alanyl aminopeptidase (ANPEP) DE7PT32 AMPN_HUMAN Substrate [4]
Phosphoglucomutase 1 (PGM1) DEA3VM1 PGM1_HUMAN Substrate [4]
Alpha-N-acetylglucosaminidase (NAG) DELOWRJ ANAG_HUMAN Substrate [4]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Tiegs RD, Body JJ, Barta JM, Heath H 3rd: Secretion and metabolism of monomeric human calcitonin: effects of age, sex, and thyroid damage. J Bone Miner Res. 1986 Aug;1(4):339-49. doi: 10.1002/jbmr.5650010407.
2 Colonic absorption of human calcitonin in man. Clin Sci (Lond). 1992 Nov;83(5):627-31.
3 Abdul Razak AR, Mau-Soerensen M, Gabrail NY, Gerecitano JF, Shields AF, Unger TJ, Saint-Martin JR, Carlson R, Landesman Y, McCauley D, Rashal T, Lassen U, Kim R, Stayner LA, Mirza MR, Kauffman M, Shacham S, Mahipal A: First-in-Class, First-in-Human Phase I Study of Selinexor, a Selective Inhibitor of Nuclear Export, in Patients With Advanced Solid Tumors. J Clin Oncol. 2016 Dec;34(34):4142-4150. doi: 10.1200/JCO.2015.65.3949. Epub 2016 Oct 31.
4 Renal metabolism of calcitonin. Am J Physiol. 1988 Apr;254(4 Pt 2):F593-600.