Details of the Drug

General Information of Drug (ID: DM0YCPL)

Drug Name
Bemcentinib
Synonyms
R428; 1037624-75-1; BGB324; R-428; BGB-324; UNII-0ICW2LX8AS; (S)-1-(6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-(7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)-1H-1,2,4-triazole-3,5-diamine; CHEMBL3809489; SYN1131; CS-1046; HY-15150; QC-11751; R 428; W-5845; Bemcentinib [USAN]; R428 (BGB324); Bemcentinib (USAN/INN); BemcentinibR428BGB324); SCHEMBL1639904; GTPL10478; BGB 324; DTXSID70673109; 1-(6,7-dihydro-5H-benzo[2,3]cyclohepta[2,4-d]pyridazin-3-yl)-3-N-[(7S)-7-pyrrolidin-1-yl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]-1,2,4-triazole-3,5-diamine; AMY16774; BCP21180; C30H34N8; EX-A1720; SYN-1131; BDBM50172079; NSC824183; s2841; WHO 10631; ZINC51951669; AKOS032947237; ACN-037541; DB12411; NSC-824183; SB16614; NCGC00386665-07; 1-(6,7-Dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N~3~-[(7S)-7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl]-1H-1,2,4-triazole-3,5-diamine; 1H-1,2,4-Triazole-3,5-diamine, 1-(6,7-dihydro-5H-benzo(6,7)cyclohepta(1,2-C)pyridazin-3-yl)-N3-((7S)-6,7,8,9-tetrahydro-7-(1-pyrrolidinyl)-5H-benzocyclohepten-2-yl)-; AC-28444; AS-16270; KB-80319; D11438; Q27236818; BGB324; BGB-324; BGB 324; R 428; R-428; Bemcentinib; 1-(6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-(7-(S)-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulene-2-yl)-1H-1,2,4-triazole-3,5-diamine
Indication
Disease Entry ICD 11 Status REF
Myelodysplastic syndrome 2A37 Phase 2 [1]
Non-small-cell lung cancer 2C25.Y Phase 2 [2]
Triple negative breast cancer 2C60-2C65 Phase 2 [3]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 2 Molecular Weight (mw) 506.6
Logarithm of the Partition Coefficient (xlogp) 5.5
Rotatable Bond Count (rotbonds) 4
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 7
Chemical Identifiers
Formula
C30H34N8
IUPAC Name
1-(3,4-diazatricyclo[9.4.0.02,7]pentadeca-1(15),2,4,6,11,13-hexaen-5-yl)-3-N-[(7S)-7-pyrrolidin-1-yl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]-1,2,4-triazole-3,5-diamine
Canonical SMILES
C1CCN(C1)[C@H]2CCC3=C(CC2)C=C(C=C3)NC4=NN(C(=N4)N)C5=NN=C6C(=C5)CCCC7=CC=CC=C76
InChI
InChI=1S/C30H34N8/c31-29-33-30(32-24-13-10-20-11-14-25(15-12-22(20)18-24)37-16-3-4-17-37)36-38(29)27-19-23-8-5-7-21-6-1-2-9-26(21)28(23)35-34-27/h1-2,6,9-10,13,18-19,25H,3-5,7-8,11-12,14-17H2,(H3,31,32,33,36)/t25-/m0/s1
InChIKey
KXMZDGSRSGHMMK-VWLOTQADSA-N
Cross-matching ID
PubChem CID
46215462
CAS Number
1037624-75-1
UNII
0ICW2LX8AS
DrugBank ID
DB12411
TTD ID
D0U8XE
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tyrosine-protein kinase UFO (AXL) TTZPY6J UFO_HUMAN Inhibitor [4]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Myelodysplastic syndrome
ICD Disease Classification 2A37
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Tyrosine-protein kinase UFO (AXL) DTT AXL 1.13E-65 -0.53 -2.04
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 109 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JK1 CTRP2 1.2231 2.8361 1.2151 27.3039
MEC1 CTRP2 2.3121 3.0921 2.3121 24.865
JM1 CTRP2 1.9513 3.5185 1.9329 22.1436
EoL-1 CTRP2 -5.2147 -2.0066 -5.216 74.2963
MOLM-16 CTRP2 -3.8682 8.5453 -6.118 55.6809
Kasumi-1 CTRP2 -1.5933 2.8683 -1.6857 50.8409
SK-MM-2 CTRP2 -1.5623 6.7448 -2.4583 50.5132
L-540 CTRP2 -1.2809 2.8205 -1.3532 48.8442
Mono-Mac-1 CTRP2 -1.1898 3.9138 -1.3874 48.3326
SEM CTRP2 -0.8463 2.4718 -0.8775 45.9649
KMS-20 CTRP2 -0.769 10.0115 -2.7544 47.0354
Pfeiffer CTRP2 -0.1134 2.8544 -0.1414 41.105
SU-DHL-6 CTRP2 0.2172 4.2414 -0.0281 35.2732
RS4;11 CTRP2 0.4417 3.2502 0.4102 37.4259
EJM CTRP2 0.4953 7.3751 -0.4209 39.2511
Ri-1 CTRP2 0.5537 4.4326 0.4029 37.0397
Hs 611.T CTRP2 0.7158 3.1345 0.6986 35.5564
MOLT-16 CTRP2 0.923 2.5592 0.9214 34.1249
OCI-Ly19 CTRP2 1.0055 5.3978 0.7074 34.5092
NU-DUL-1 CTRP2 1.0311 2.3948 1.0292 28.6526
EB1 CTRP2 1.0706 3.2231 1.0585 33.1763
TALL-1 [Human adult T-ALL] CTRP2 1.2459 3.1572 1.2389 31.9918
OCI-Ly3 CTRP2 1.2527 4.4544 1.1478 32.2697
HuT 78 CTRP2 1.2588 5.123 1.0413 32.5943
SUP-T1 CTRP2 1.2666 3.0287 1.2203 21.7903
697 CTRP2 1.2814 2.6354 1.2808 31.7338
KMS-34 CTRP2 1.2856 2.643 1.285 31.7059
MOLM-6 CTRP2 1.3098 2.9553 1.3072 31.5512
SUP-M2 CTRP2 1.409 2.1672 1.409 30.8814
GA-10 CTRP2 1.4181 2.1733 1.4181 30.821
Granta-519 CTRP2 1.4642 3.152 1.4603 30.5268
Karpas-299 CTRP2 1.5238 3.3808 1.4461 19.9443
MOLT-3 CTRP2 1.5572 2.0657 1.5572 29.8944
Daudi CTRP2 1.5698 2.6118 1.5692 24.8026
Kasumi-2 CTRP2 1.5855 4.1052 1.5394 29.8601
RCH-ACV CTRP2 1.5969 3.883 1.5683 29.7256
DB CTRP2 1.6418 3.2634 1.6273 24.3386
OCI-AML-2 CTRP2 1.6491 3.5227 1.3711 12.9321
PL21 CTRP2 1.6547 3.5562 1.6439 29.2807
OPM-2 CTRP2 1.6644 2.5838 1.6644 29.1799
KMS-12-BM CTRP2 1.6747 3.2377 1.6716 29.122
CA46 CTRP2 1.7052 3.2147 1.7028 28.9164
KYO-1 CTRP2 1.7236 3.2279 1.7212 28.7937
MOLT-13 CTRP2 1.7266 4.7512 1.6119 29.1519
RPMI-6666 CTRP2 1.7628 4.1317 1.7229 28.6583
SET-2 CTRP2 1.8197 3.1395 1.8142 23.0365
BV-173 CTRP2 1.8457 3.4697 1.8407 27.989
MOLP-8 CTRP2 1.852 3.1505 1.851 27.9339
Reh CTRP2 1.8559 3.0389 1.8391 17.1609
KMS-11 CTRP2 1.8784 4.0435 1.8501 27.8491
MOTN-1 CTRP2 1.8821 3.2188 1.8755 22.5951
HPB-ALL CTRP2 1.8883 3.2504 1.8868 27.6936
L-428 CTRP2 1.8936 3.2838 1.8918 27.6591
SKM-1 CTRP2 1.9004 3.8334 1.7649 17.2936
SUP-T11 CTRP2 1.9156 3.2793 1.914 27.5117
LP-1 CTRP2 1.9169 3.2415 1.9156 27.5021
Namalwa CTRP2 1.9405 3.3445 1.9384 27.3475
SUP-HD1 CTRP2 1.9444 3.7128 1.9346 27.3478
AML-193 CTRP2 1.9539 4.2884 1.9096 27.4003
M-07e CTRP2 2.0213 3.5676 2.0166 26.8181
A3/Kawakami CTRP2 2.1019 2.8203 2.1019 26.2652
A4/Fukuda CTRP2 2.105 2.9563 2.1046 20.9817
Karpas-422 CTRP2 2.1231 3.1017 2.1229 26.1248
KO52 CTRP2 2.1396 2.8333 2.1396 26.0142
F-36P CTRP2 2.151 4.8462 2.0524 26.2723
SUP-B15 CTRP2 2.1576 3.9484 2.1117 20.7712
ST486 CTRP2 2.1803 3.0886 2.1795 20.4456
THP-1 CTRP2 2.1972 7.092 0.8194 20.4488
CMK CTRP2 2.1976 3.2681 2.1973 25.6288
Mono-Mac-6 CTRP2 2.2227 10.4403 -0.2567 29.1215
SU-DHL-8 CTRP2 2.2581 3.3647 2.2321 14.1154
L-363 CTRP2 2.2686 3.2548 2.2667 19.8196
NB4 CTRP2 2.2787 8.0661 -0.1248 18.3433
JJN-3 CTRP2 2.2897 3.6046 2.2875 25.0217
MHH-CALL-4 CTRP2 2.3172 5.7475 2.0539 25.7375
SR CTRP2 2.3465 3.4023 2.3215 13.4345
NU-DHL-1 CTRP2 2.3968 5.0269 2.2882 24.6701
NOMO-1 CTRP2 2.4115 4.7006 2.0607 14.2958
KMS-18 CTRP2 2.4356 4.8274 2.3592 24.3011
RL CTRP2 2.4395 2.8911 2.4395 18.5927
OCI-M1 CTRP2 2.4571 3.0232 2.4571 23.8991
K-562 CTRP2 2.4722 3.0313 2.4722 18.3594
BL-70 CTRP2 2.4753 2.9448 2.4753 18.3372
MOLP-2 CTRP2 2.4952 4.2062 2.4384 18.4017
OCI-AML-3 CTRP2 2.5154 2.9996 2.5154 18.0514
Ci-1 CTRP2 2.5228 2.9227 2.5228 17.9981
RPMI-8226 CTRP2 2.529 3.9431 2.4238 12.3586
SIG-M5 CTRP2 2.6009 2.9295 2.6009 17.4407
Raji CTRP2 2.7374 4.4981 2.4845 11.3875
ME1 CTRP2 2.7423 5.514 2.5704 22.5902
U266B1 CTRP2 2.7905 5.0832 2.7021 21.9786
TF-1 CTRP2 2.8001 4.2806 2.7535 16.1883
OCI-Ly10 CTRP2 2.9409 11.9447 0.23 29.7189
P3HR-1 CTRP2 2.9498 4.3409 2.7685 9.4593
U-937 CTRP2 2.968 6.041 2.6879 21.4732
MC116 CTRP2 2.9864 4.0471 2.9847 20.3784
HEL 92.1.7 CTRP2 3.0159 7.4429 1.9106 18.92
MHH-CALL-3 CTRP2 3.0885 8.5587 1.4753 20.4947
GDM-1 CTRP2 3.14 9.0283 0.1376 14.8548
HD-MY-Z CTRP2 3.5203 5.4516 3.2545 11.8984
HL-60 CTRP2 3.7784 5.9284 3.6021 15.7098
SU-DHL-4 CTRP2 3.95 6.2878 3.6879 14.8796
Toledo CTRP2 4.0524 6.5784 3.7043 14.5179
Mino CTRP2 4.1702 6.7115 3.4042 9.4181
OCI-AML-5 CTRP2 4.4987 6.0964 4.343 10.8442
Karpas-620 CTRP2 5.0982 7.6871 4.3445 9.2093
AMO1 CTRP2 6.2084 7.8217 3.5584 0.3046
REC-1 CTRP2 6.5316 11.7475 3.588 9.3994
MM1.S CTRP2 7.808 13.2132 3.8019 6.4985
⏷ Show the Full List of 109 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE8 CTRP2 2.2353 3.9277 2.2244 25.4135
TE15 CTRP2 2.6128 9.3577 0.6332 25.0424
OE33 CTRP2 1.8222 16.0674 -2.8089 38.7626
OE21 CTRP2 2.292 4.0473 2.2426 19.8249
TE-5 CTRP2 2.5165 3.88 2.4957 18.1182
TE-11 CTRP2 2.6073 5.6441 2.1998 18.9538
TE-6 CTRP2 2.6387 4.3604 2.6187 22.7561
KYSE-30 CTRP2 2.6491 3.2557 2.6491 22.6198
TE-4 CTRP2 2.8802 4.5469 2.8571 21.1577
TE-1 CTRP2 3.0514 6.9854 2.4801 21.9796
TE-14 CTRP2 3.284 5.21 3.2119 18.6353
KYSE-410 CTRP2 3.585 5.4652 3.3198 11.4361
KYSE-70 CTRP2 4.1319 9.887 2.3644 19.4866
EC-GI-10 CTRP2 4.2516 10.4846 1.6383 16.8702
KYSE-510 CTRP2 4.8651 6.0952 4.7431 8.2851
OE19 CTRP2 5.0135 8.139 4.0498 10.6113
KYSE-150 CTRP2 5.1412 6.5186 4.8982 6.9049
KYSE-450 CTRP2 7.5792 12.2466 4.1103 5.5949
KYSE-520 CTRP2 8.9307 19.1671 1.705 12.7057
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 4.8173 8.3046 3.7793 12.1864
HPAC CTRP2 1.6962 2.9082 1.6958 28.9699
PaTu 8988s CTRP2 2.0326 5.542 1.6093 23.0959
HuP-T4 CTRP2 2.0407 6.9735 1.3901 28.886
MIA PaCa-2 CTRP2 2.2167 2.9303 2.2167 25.5005
PANC-1 CTRP2 2.2983 4.1601 2.2782 25.0242
Panc 08.13 CTRP2 2.3324 5.8386 2.0477 25.7113
PSN1 CTRP2 2.3766 7.7406 1.4776 27.5487
PaTu 8988t CTRP2 2.5025 4.4854 2.4676 23.714
Panc 03.27 CTRP2 2.7214 5.0074 2.6394 22.4166
SU.86.86 CTRP2 2.7536 4.5108 2.7279 22.0103
PK-45H CTRP2 2.9784 10.4154 0.9731 27.4288
PK-59 CTRP2 3.1813 7.0105 2.6113 21.1167
Hs 766T CTRP2 3.4678 10.0443 1.6336 23.8866
SW1990 CTRP2 3.7074 7.9313 2.3771 15.0772
Capan-2 CTRP2 3.7329 5.8283 3.5773 15.9388
SNU-410 CTRP2 3.8098 8.4222 2.7086 18.9993
Panc 10.05 CTRP2 3.8785 6.8581 3.4174 16.0948
Capan-1 CTRP2 3.9648 7.3703 3.313 16.25
AsPC-1 CTRP2 4.296 8.9748 2.9519 16.7926
Panc 04.03 CTRP2 4.3163 6.3021 4.0823 12.3428
Panc 05.04 CTRP2 4.7414 14.8655 0.5059 24.3952
Panc 02.03 CTRP2 4.8236 8.1062 3.8778 11.773
DAN-G CTRP2 4.9027 8.351 3.8416 11.7255
L3.3 CTRP2 4.9177 9.4447 3.3334 13.7579
HuP-T3 CTRP2 4.9179 9.3424 2.7891 10.4067
KP-2 CTRP2 5.1585 8.5226 3.3994 7.1741
YAPC CTRP2 7.6187 8.833 5.6456 0.2073
PaTu 8902 CTRP2 7.6797 9.7704 5.3032 1.0455
TCC-Pan2 CTRP2 7.9588 16.0418 2.5374 11.1862
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 1.7158 3.8368 1.6943 28.9098
Malme-3M CTRP2 0.7996 11.6731 -1.806 40.4597
IGR-1 CTRP2 1.7932 3.4562 1.7877 28.3406
COLO 792 CTRP2 2.2589 3.5223 2.2573 25.2249
Hs 294T CTRP2 2.263 3.8636 2.2549 25.2193
Hs 940.T CTRP2 2.2743 3.3688 2.2737 25.1189
Hs 944.T CTRP2 2.3022 4.198 2.2799 25.0059
A101D CTRP2 2.3091 4.1985 2.2871 24.9588
COLO 800 CTRP2 2.374 3.8844 2.3675 24.4744
K029AX CTRP2 2.3981 4.7972 2.3233 24.5455
Mel JuSo CTRP2 2.4075 3.2985 2.3948 12.9192
SK-MEL-24 CTRP2 2.4114 3.9926 2.4023 24.2339
UACC-257 CTRP2 2.4209 2.9219 2.4208 18.726
A2058 CTRP2 2.4478 2.8948 2.4478 23.9609
WM115 CTRP2 2.4556 4.1809 2.4395 23.963
SK-MEL-3 CTRP2 2.459 2.9601 2.459 18.4538
HT-144 CTRP2 2.4623 4.112 2.4497 23.9066
Hs 688(A).T CTRP2 2.4624 3.1502 2.4624 23.8635
CJM [Human melanoma] CTRP2 2.4812 2.9142 2.4812 18.295
WM266-4 CTRP2 2.5352 2.9555 2.5352 23.3785
IGR-37 CTRP2 2.5369 2.9666 2.5369 23.3675
Hs 895.T CTRP2 2.5541 6.0713 2.228 24.3863
WM88 CTRP2 2.574 4.7518 2.4223 18.1947
IGR-39 CTRP2 2.5746 3.2312 2.5746 23.1161
Hs 839.T CTRP2 2.8106 5.1358 2.581 16.808
WM983B CTRP2 2.8232 5.6034 2.4475 17.2934
SK-MEL-5 CTRP2 2.8403 3.9566 2.8384 21.3525
HMCB CTRP2 2.8703 4.7674 2.8276 21.2903
SK-MEL-30 CTRP2 2.8852 4.0765 2.882 21.0577
MeWo CTRP2 3.0984 5.2403 3.0078 19.9351
COLO 829 CTRP2 3.1913 5.5578 3.0488 19.4978
SK-MEL-28 CTRP2 4.0125 5.4113 3.9622 13.7076
RVH-421 CTRP2 4.0917 7.8793 2.7715 12.3861
G-361 CTRP2 4.1037 13.018 0.8325 24.9079
WT2-iPS CTRP2 4.2827 7.1607 3.7334 13.7565
LOX-IMVI CTRP2 4.5739 7.0875 4.0703 11.6574
Hs 852.T CTRP2 5.2164 17.5275 -0.401 25.8762
UACC-62 CTRP2 5.9754 9.0383 3.76 4.1188
WM1799 CTRP2 7.3699 13.2105 3.497 8.3666
SK-MEL-31 CTRP2 7.5535 9.1637 5.4911 0.5861
A-375 CTRP2 7.721 18.5555 1.1252 16.5628
Hs 936.T CTRP2 7.7724 8.9274 5.6703 0.1284
MDA-MB-435S CTRP2 7.9915 15.1187 3.0097 9.3365
IPC-298 CTRP2 8.0958 9.4639 5.6014 0.151
WM793 CTRP2 8.303 9.5513 5.6453 0.0704
⏷ Show the Full List of 45 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CHP-126 CTRP2 1.9379 3.9676 1.9165 27.4295
Kelly CTRP2 1.9412 3.1568 1.9188 16.5293
IMR-32 CTRP2 2.0899 3.2216 2.0866 21.1001
SK-N-FI CTRP2 2.0972 2.8425 2.0971 21.0364
SK-N-AS CTRP2 2.3487 3.0297 2.3487 24.6214
SK-N-SH CTRP2 2.3908 3.2931 2.3907 24.3411
NH-6 CTRP2 2.3999 3.5239 2.3991 24.2828
SK-N-DZ CTRP2 2.4641 3.033 2.4641 23.8524
CHP-212 CTRP2 2.4691 3.1313 2.4691 23.8189
KP-N-SI9s CTRP2 2.4864 5.5582 1.798 15.2208
NB1 CTRP2 2.67 4.2629 2.4893 11.5941
SK-N-BE(2) CTRP2 3.7345 5.6589 3.6174 15.7919
KP-N-YN CTRP2 5.2819 8.6026 3.4592 6.6617
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-869 CTRP2 2.599 4.5845 2.4857 17.8716
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-673 CTRP2 1.8351 3.1433 1.8341 28.0464
SK-N-MC CTRP2 1.9981 3.0028 1.9979 26.9577
TC71 CTRP2 2.2296 3.6756 2.2115 20.1561
Hs 888.T CTRP2 2.2512 5.2282 2.0956 25.8016
SK-ES-1 CTRP2 2.3275 4.9861 2.2203 25.1269
SJSA-1 CTRP2 2.5002 3.7649 2.4978 23.6199
MG-63 CTRP2 2.5198 2.9745 2.5197 18.0201
SaOS-2 CTRP2 2.8448 4.5378 2.8209 21.3962
CAL-78 CTRP2 2.8763 6.085 1.9601 13.3264
G-292 clone A141B1 CTRP2 3.9903 7.4192 3.3203 16.1518
Hs 822.T CTRP2 4.4198 6.12 4.2503 11.4188
HOS CTRP2 4.6885 7.9508 3.8138 12.369
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 53 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-51 CTRP2 1.3528 4.0789 1.2975 31.4403
MDA-MB-468 CTRP2 1.5374 2.4956 1.5374 30.0264
CAL-85-1 CTRP2 1.9591 3.7751 1.9474 27.2562
BT-474 CTRP2 2.1419 5.8277 1.8427 27.0252
HCC1500 CTRP2 2.2742 3.8322 2.2673 25.1404
AU565 CTRP2 2.5731 4.798 2.5094 23.3417
HCC38 CTRP2 3.2487 5.8488 3.0445 19.3348
HCC1419 CTRP2 3.4092 6.7771 2.6066 14.9032
BT-549 CTRP2 3.7343 7.0607 2.8097 13.1444
SK-BR-3 CTRP2 3.8289 5.6981 3.7116 15.1642
EFM-192A CTRP2 3.8757 6.8667 3.04 11.7743
HCC202 CTRP2 4.0717 8.4285 2.9739 17.2807
Hs 578Bst CTRP2 4.1287 9.2751 2.6468 18.409
T-47D CTRP2 4.1378 8.1457 3.1665 16.3541
HCC1428 CTRP2 4.1938 5.6983 3.8817 7.311
ZR-75-30 CTRP2 4.2382 8.2802 2.7137 12.2812
MDA-MB-453 CTRP2 4.2958 6.6301 3.9493 12.8971
BT-20 CTRP2 4.4862 7.1391 3.9568 12.3359
MDA-MB-361 CTRP2 4.533 6.2334 4.3397 10.7532
MDA-MB-231 CTRP2 4.9718 12.2278 0.7288 14.0056
MDA-MB-415 CTRP2 5.2114 8.2438 4.1916 9.56
ZR-75-1 CTRP2 8.0204 9.6185 5.5166 0.3101
HCC1143 CTRP2 8.8815 14.3697 3.9411 4.6212
BT 239 CTRP2 2.3148 2.9186 2.3148 24.8468
BT 145 CTRP2 2.3532 3.1705 2.3527 19.2108
BT 228 CTRP2 2.4611 2.8826 2.4611 23.8725
BT 231 CTRP2 2.5508 4.6537 2.5023 23.4387
BT 139 CTRP2 2.567 2.9294 2.567 23.1671
BT 112 CTRP2 2.5974 3.0074 2.5974 22.9643
BT164 CTRP2 2.6108 2.9763 2.6108 17.3699
BT 504 CTRP2 2.8022 3.3616 2.8022 21.6002
BT 440 CTRP2 2.844 4.4885 2.8235 21.3903
BT 248 CTRP2 3.0168 4.6452 2.9923 20.2527
BT 245 CTRP2 3.3497 5.3261 3.2639 18.2451
BT 159 CTRP2 4.0827 5.0859 4.0704 13.1103
BT 131 CTRP2 4.3004 6.0592 4.1371 12.1904
BT 224 CTRP2 4.3219 6.3436 4.0752 12.3523
BT147 CTRP2 4.3919 6.524 4.0905 12.0909
BT 216 CTRP2 4.3984 7.1223 3.8711 12.9077
BT 232 CTRP2 4.4635 6.4477 4.1942 11.4958
BT 187 CTRP2 4.4903 6.2329 4.2934 11.05
BT 359 CTRP2 4.5213 6.9384 4.0746 11.7851
BT 172 CTRP2 4.535 6.2568 4.3346 10.766
BT 333 CTRP2 5.0824 6.9485 4.66 7.9893
BT 179 CTRP2 5.2392 9.2326 3.1103 8.3102
BT 428 CTRP2 5.2739 7.7528 4.4862 8.2061
BT 498 CTRP2 7.4043 8.4748 5.692 0.1932
BT 422 CTRP2 7.5347 8.8345 5.611 0.3053
BT 340 CTRP2 7.6032 9.3208 5.451 0.6648
BT 320 CTRP2 7.6279 10.5973 4.913 2.4301
BT 444 CTRP2 7.6911 8.6366 5.7415 0.0618
BT 328 CTRP2 7.7202 10.0048 5.2248 1.2603
BT 482 CTRP2 7.8795 10.4538 5.1159 1.4803
⏷ Show the Full List of 53 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-172 CTRP2 0.9525 3.5903 0.9185 34.0349
KNS-60 CTRP2 1.6131 3.2526 1.6092 29.5349
D283 Med CTRP2 2.3269 3.6283 2.315 19.4394
Hs 683 CTRP2 2.3282 3.2368 2.3281 24.7585
M059K CTRP2 2.3309 4.4237 2.293 24.8674
42-MG-BA CTRP2 2.3407 2.9148 2.3407 24.6746
GOS-3 CTRP2 2.3694 4.0228 2.3581 24.521
SF539 CTRP2 2.3718 3.0138 2.3718 24.4671
YH-13 CTRP2 2.3982 4.4871 2.358 24.4266
U-118MG CTRP2 2.4217 3.1995 2.4217 24.1348
SF268 CTRP2 2.452 4.1994 2.4348 23.9909
SNB-75 CTRP2 2.5106 4.2918 2.4902 23.6111
YKG-1 CTRP2 2.5503 3.5894 2.5497 23.2799
KNS-81 CTRP2 2.6182 3.1431 2.6182 22.8258
GMS-10 CTRP2 2.6311 3.0884 2.6311 22.74
SW1088 CTRP2 2.6864 10.1984 -0.2019 23.2146
GaMG CTRP2 2.7601 4.0668 2.6444 10.6336
SW1783 CTRP2 2.9975 8.4509 1.435 20.9074
CCF-STTG1 CTRP2 3.2273 4.3637 3.2228 18.783
KG-1-C CTRP2 3.3631 18.8989 -2.7345 34.8326
DK-MG CTRP2 3.4912 5.813 3.0914 12.6473
KNS-42 CTRP2 3.7194 6.7984 3.2675 17.1145
Becker CTRP2 3.8289 7.9385 2.9361 18.0719
KALS-1 CTRP2 4.2737 5.8256 3.9108 6.9606
T98G CTRP2 4.6471 15.9784 -0.1303 26.4146
U-251MG CTRP2 4.9294 6.2604 4.7624 8.0228
DBTRG-05MG CTRP2 5.642 10.1471 2.2347 6.0231
8-MG-BA CTRP2 7.6266 14.3267 3.1364 9.3992
TM-31 CTRP2 7.7328 20.8676 -0.0114 20.0103
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
EN CTRP2 1.9695 2.9994 1.9693 27.1482
JHUEM-7 CTRP2 1.9709 3.3386 1.9692 27.1439
JHUEM-3 CTRP2 2.0434 7.2854 0.9696 25.5122
JHUEM-1 CTRP2 2.2147 3.3492 2.2141 25.5159
AN3-CA CTRP2 2.4203 4.7865 2.3483 24.388
EFE-184 CTRP2 3.0549 6.5143 1.9339 12.9471
HEC-1-A CTRP2 3.1094 5.1512 3.0336 19.8108
ESS-1 CTRP2 3.1201 5.4209 2.9991 19.8967
MFE-296 CTRP2 3.2002 5.2137 3.1214 19.2165
HEC-50B CTRP2 3.5936 5.2456 3.5379 16.5166
HEC-151 CTRP2 4.2903 7.021 2.7861 5.8538
MFE-319 CTRP2 5.1092 7.6858 4.3559 9.1358
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KMRC-3 CTRP2 0.0436 3.2038 -0.0001 40.1065
CAL-54 CTRP2 2.1159 4.0538 2.0956 26.2401
UO-31 CTRP2 2.2411 4.7036 2.1682 25.5843
KMRC-2 CTRP2 2.3101 2.8669 2.3101 24.8787
KMRC-1 CTRP2 2.3972 2.9687 2.3972 24.2979
TUHR10TKB CTRP2 2.5776 3.1694 2.5776 23.0963
VMRC-RCZ CTRP2 3.5565 5.3345 3.485 16.8181
VMRC-RCW CTRP2 3.5827 10.0833 1.7303 23.2397
ACHN CTRP2 3.7449 7.6793 2.9559 18.2253
786-O CTRP2 4.1245 6.626 3.3989 9.561
TUHR14TKB CTRP2 5.2119 7.3642 4.6067 7.8689
RCC10RGB CTRP2 5.3132 9.229 3.8081 10.9097
Caki-2 CTRP2 6.2024 13.5927 2.4011 14.7665
Caki-1 CTRP2 6.3591 14.573 2.0395 15.8269
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H747 CTRP2 1.1341 4.4282 1.0249 33.0716
LoVo CTRP2 1.6078 5.4247 1.3566 30.3979
GP2d CTRP2 1.61 7.6499 0.688 32.4833
NCI-H716 CTRP2 2.0692 3.4331 2.0672 26.4901
CL-11 CTRP2 2.3011 4.6742 2.2356 25.1598
SNU-C1 CTRP2 2.3082 3.8358 2.2816 19.6259
C2BBe1 CTRP2 2.392 4.6809 2.2403 19.4929
LS1034 CTRP2 2.4217 3.3706 2.4197 18.7271
SNU-61 CTRP2 2.547 16.9808 -2.5556 36.5224
SW948 CTRP2 2.6675 3.7447 2.6598 16.993
HCT 15 CTRP2 2.7021 4.1074 2.6701 16.8343
SNU-C5 CTRP2 2.8539 7.2903 1.3696 16.1137
RKO CTRP2 2.9041 4.5422 2.8823 20.9944
KM12 CTRP2 2.9399 4.3726 2.7471 9.5842
NCI-H508 CTRP2 2.9536 4.318 2.7802 9.3969
CW-2 CTRP2 3.106 5.3554 2.9961 19.9519
COLO 320 CTRP2 3.1388 6.833 2.6278 21.1803
SW1417 CTRP2 3.3746 6.0423 2.8778 13.8713
CCK-81 CTRP2 3.3977 6.3431 2.3434 10.0959
COLO201 CTRP2 3.5354 6.4233 2.4326 9.3141
SNU-1033 CTRP2 3.6403 5.7127 3.5033 16.4895
HCT 8 CTRP2 4.0984 5.4185 4.053 13.1185
COLO 678 CTRP2 4.2076 9.9469 1.865 16.0278
LS123 CTRP2 4.3336 8.299 3.298 15.328
RCM-1 [Human ESC] CTRP2 4.8833 7.2961 4.304 9.9166
SNU-C4 CTRP2 4.9774 6.4296 4.7559 7.9079
SNU-503 CTRP2 5.1188 11.4923 1.8822 13.9267
HCC-56 CTRP2 5.6503 8.3463 3.8671 4.1723
MDST8 CTRP2 7.5028 9.574 5.2957 1.2118
HT-55 CTRP2 7.98 9.2766 5.6244 0.1452
SNU-407 CTRP2 8.3228 14.6022 3.4828 7.037
SW620 CTRP2 8.647 10.3981 5.4769 0.1989
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 17 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-886 CTRP2 0.3499 7.0458 -0.4699 39.9182
SNU-398 CTRP2 2.1426 6.3034 1.7128 27.4714
SNU-761 CTRP2 2.168 3.1723 2.1678 25.826
HLF CTRP2 2.2288 3.5474 2.2267 25.4273
SNU-423 CTRP2 2.4899 4.9918 2.2708 19.0523
JHH-1 CTRP2 2.5209 2.8908 2.5209 23.4739
HuH-1 CTRP2 2.6102 4.6809 2.5622 23.041
SNU-449 CTRP2 2.6722 4.435 2.5929 17.2219
JHH-5 CTRP2 3.0143 4.9179 2.9634 20.3592
JHH-4 CTRP2 3.0515 7.5633 2.2665 22.7633
SNU-387 CTRP2 3.8152 6.3437 3.2132 11.2
JHH-2 CTRP2 3.9198 7.0643 3.3849 16.1002
PLC/PRF/5 CTRP2 4.7273 8.4666 3.615 13.0711
JHH-6 CTRP2 5.4748 5.8502 5.463 3.8346
SK-HEP-1 CTRP2 5.524 10.9137 3.1636 13.1081
Hep-G2 CTRP2 7.7202 9.8 5.311 0.9913
SNU-475 CTRP2 7.9654 17.6027 1.7776 13.9412
⏷ Show the Full List of 17 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 93 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2228 CTRP2 0.6682 5.3191 0.3582 36.7393
DV-90 CTRP2 0.7712 9.4446 -1.2707 36.4248
NCI-H889 CTRP2 0.9521 4.8063 0.7695 34.5089
PC-14 CTRP2 0.99 2.3839 0.9896 33.6744
Lu-65 CTRP2 1.1969 6.78 0.5365 34.3297
SK-MES-1 CTRP2 1.2019 3.7491 1.1669 32.3776
EBC-1 CTRP2 1.2721 4.4101 1.1744 32.1175
COR-L51 CTRP2 1.6975 3.1746 1.6954 28.9664
NCI-H1944 CTRP2 1.7274 4.7514 1.5001 24.516
EPLC-272H CTRP2 1.812 8.5049 0.2099 28.9099
NCI-H1703 CTRP2 1.896 5.1587 1.5766 23.6663
NCI-H1105 CTRP2 1.9155 4.1905 1.8778 27.6336
NCI-H2087 CTRP2 1.9683 4.7764 1.8671 27.4978
NCI-H1666 CTRP2 2.0425 4.5106 1.9806 26.8699
NCI-H810 CTRP2 2.1172 3.3542 2.111 20.9153
NCI-H1693 CTRP2 2.1445 3.9065 2.1322 26.023
NCI-H1341 CTRP2 2.1739 3.244 2.1712 20.4985
LCLC-97TM1 CTRP2 2.1987 4.2262 2.1178 20.6068
NCI-H1755 CTRP2 2.1997 11.0307 -0.0915 32.7048
COLO 668 CTRP2 2.2244 4.7119 2.0508 20.7709
NCI-H1694 CTRP2 2.3714 3.1909 2.3713 24.4704
NCI-H841 CTRP2 2.3728 4.4432 2.3353 24.5869
EKVX CTRP2 2.3817 5.268 2.2293 24.9223
VMRC-LCD CTRP2 2.3928 4.242 2.3236 19.1782
NCI-H1568 CTRP2 2.4081 3.3643 2.4061 18.8243
COR-L95 CTRP2 2.4497 3.6401 2.4483 23.953
NCI-H1435 CTRP2 2.4655 9.2396 -2.762 11.9306
NCI-H520 CTRP2 2.4812 3.4958 2.4808 23.7401
NCI-H446 CTRP2 2.4958 3.2952 2.4957 23.6415
NCI-H522 CTRP2 2.525 4.8517 2.345 18.6521
NCI-H2196 CTRP2 2.5532 3.2017 2.5531 17.7816
NCI-H1650 CTRP2 2.5657 5.2751 2.4269 23.6501
ChaGo-K-1 CTRP2 2.5682 4.5231 2.4645 18.055
NCI-H2286 CTRP2 2.5988 6.3053 1.5816 15.8658
NCI-H2029 CTRP2 2.6042 3.5351 2.6015 17.4269
DMS 273 CTRP2 2.6498 4.1887 2.6389 22.6517
NCI-H1355 CTRP2 2.6803 5.4642 2.3387 18.1743
LK2 CTRP2 2.6854 3.0136 2.6854 16.838
HOP-92 CTRP2 2.7029 7.9089 1.761 25.5944
LOU-NH91 CTRP2 2.7034 5.63 2.5025 22.9512
DMS 53 CTRP2 2.726 4.5647 2.6948 22.2124
DMS 114 CTRP2 2.7499 4.0207 2.746 21.9612
LUDLU-1 CTRP2 2.7692 5.9687 2.2594 18.2142
SW1271 CTRP2 2.788 4.5648 2.7597 21.7898
NCI-H1573 CTRP2 2.8783 4.0136 2.876 21.1008
LXF 289 CTRP2 2.9288 9.7037 1.2421 26.705
NCI-H647 CTRP2 3.0432 6.1067 2.5003 16.4073
HCC4006 CTRP2 3.0702 6.3928 2.6971 21.1304
NCI-H1623 CTRP2 3.1253 6.1467 2.8301 20.482
HCC1195 CTRP2 3.2829 6.1419 3.0035 19.3771
NCI-H2170 CTRP2 3.2973 5.6672 2.9376 13.8602
NCI-H322 CTRP2 3.4199 5.3298 3.3389 17.7608
SK-LU-1 CTRP2 3.4395 8.9044 2.1172 22.225
A-549 CTRP2 3.4404 6.4591 2.3271 10.0617
NCI-H2085 CTRP2 3.5878 8.6589 2.3769 20.8561
DMS 454 CTRP2 3.6129 5.5954 3.4986 16.5915
RERF-LC-Ad2 CTRP2 3.6152 6.5583 3.2371 17.5312
NCI-H1184 CTRP2 3.6245 11.0276 1.331 24.5084
NCI-H1563 CTRP2 3.6359 5.4461 3.5518 16.3332
NCI-H1915 CTRP2 3.6631 7.7037 2.441 14.9188
NCI-H2110 CTRP2 3.7973 6.6892 3.0418 11.9786
T3M-10 CTRP2 3.8956 8.4062 2.331 14.7949
NCI-H1373 CTRP2 3.931 8.1921 2.9335 17.8083
HOP-62 CTRP2 3.9437 8.459 2.8297 18.1775
NCI-H1793 CTRP2 4.0642 8.1262 3.0994 16.81
COR-L105 CTRP2 4.0816 6.8416 3.6419 14.6683
NCI-H1651 CTRP2 4.0917 6.0627 3.9083 13.6515
LC-1/sq-SF CTRP2 4.1664 6.469 3.513 8.9565
HCC2935 CTRP2 4.1666 7.027 3.6626 14.3501
RERF-LC-MS CTRP2 4.1932 7.3012 3.5821 14.5856
NCI-H2172 CTRP2 4.3057 7.2767 2.6709 6.3772
NCI-H2444 CTRP2 4.378 4.9873 4.3766 11.1063
NCI-H661 CTRP2 4.4355 7.1643 2.8286 5.3548
NCI-H2342 CTRP2 4.4939 11.1802 2.0924 19.6263
NCI-H1792 CTRP2 4.5623 9.9581 1.5378 11.2334
NCI-H838 CTRP2 4.5627 7.4665 3.4117 8.4131
NCI-H1339 CTRP2 4.7273 6.6087 4.4213 9.8846
NCI-H226 CTRP2 4.7611 5.3232 4.7577 8.5609
Calu-1 CTRP2 5.2063 10.4835 3.0928 14.0811
HCC1438 CTRP2 5.2792 6.3606 5.1058 5.726
NCI-H2122 CTRP2 5.3569 7.6401 3.2243 2.0565
KNS-62 CTRP2 5.3648 6.5617 5.1176 5.4436
NCI-H441 CTRP2 5.4664 13.6353 -0.3868 12.3717
IA-LM CTRP2 5.4692 8.5699 3.6219 5.5792
Sq-1 CTRP2 5.5503 15.1182 -0.2613 16.8194
NCI-H1869 CTRP2 6.6119 12.0428 3.504 9.6018
NCI-H1395 CTRP2 7.0728 12.5456 2.8196 6.4906
NCI-H524 CTRP2 7.8207 9.4413 5.5007 0.4233
NCI-H2126 CTRP2 7.8497 9.2239 5.5937 0.2262
NCI-H460 CTRP2 7.9919 14.8691 1.4979 5.9484
Calu-6 CTRP2 8.0953 14.0751 3.5828 6.9594
NCI-H2023 CTRP2 9.0123 10.8154 5.4646 0.145
Hs 888.Lu CTRP2 4.5419 9.4302 2.4198 12.8647
⏷ Show the Full List of 93 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 2.0602 4.2352 1.9675 21.6385
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 2.125 7.1165 1.4327 28.4784
COV434 CTRP2 0.0002 2.2775 -0.0059 40.2863
OVCAR-5 CTRP2 0.8682 17.7188 -4.5176 43.0037
Caov-3 CTRP2 1.2753 6.8374 0.6034 33.8661
COV362 CTRP2 2.0608 5.9526 1.5018 23.4225
COV644 CTRP2 2.0693 5.8255 1.764 27.5273
A2780 CTRP2 2.2225 3.7779 2.1966 20.235
FU-OV-1 CTRP2 2.3851 6.1557 1.7778 21.3229
OAW28 CTRP2 2.4321 5.0866 2.3164 24.4596
RMG-I CTRP2 2.4348 7.4803 1.6372 26.8275
OV7 CTRP2 2.5447 4.5016 2.5104 23.4307
TOV-112D CTRP2 2.5722 4.7706 2.416 18.2247
OAW42 CTRP2 2.5772 4.8632 2.5054 23.3422
OC 314 CTRP2 2.7059 3.8671 2.704 22.2476
IGROV-1 CTRP2 2.8419 5.5854 2.1521 12.5442
JHOS-2 CTRP2 2.9566 7.3102 1.9083 19.098
OVK18 CTRP2 3.8108 5.2202 3.7725 15.0102
TYK-nu CTRP2 3.9543 6.6438 2.6967 7.0236
EFO-27 CTRP2 4.0548 8.505 2.4332 13.9562
JHOM-1 CTRP2 4.1116 7.6109 2.9198 11.6858
MCAS CTRP2 4.1465 6.1036 3.6583 8.3871
OVCAR-4 CTRP2 4.5468 6.6457 3.168 3.5225
OVCAR-8 CTRP2 4.559 8.0667 2.4758 6.8015
OV56 CTRP2 4.961 8.0661 4.0324 10.8095
SK-OV-3 CTRP2 5.6982 16.5283 0.5112 22.3
OV-90 CTRP2 6.1405 12.1399 3.0764 12.2195
SNU-840 CTRP2 6.4824 14.9636 0.4929 12.1882
EFO-21 CTRP2 7.24 12.395 2.998 5.525
HEY A8 CTRP2 7.4549 15.8404 2.2665 13.0147
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SYO-1 CTRP2 2.2889 5.3668 2.109 25.635
H-STS CTRP2 2.5113 3.1822 2.5113 23.5377
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Yamato-SS CTRP2 3.5505 6.6903 3.1225 18.1454
RD CTRP2 0.9517 4.8343 0.764 34.5272
TE 441.T CTRP2 1.9154 2.8692 1.9154 27.5079
A-204 CTRP2 2.054 4.5313 1.9903 26.7992
TE 617.T CTRP2 2.0963 3.3382 2.0952 26.3064
G-401 CTRP2 2.3122 4.1749 2.2472 19.7381
Hs 729.T CTRP2 2.3363 4.3289 2.3064 24.804
Rh18 CTRP2 2.3616 3.7971 2.2746 13.5658
BT-16 CTRP2 2.3934 3.4196 2.393 24.325
GCT CTRP2 2.446 3.9825 2.4379 23.9999
TTC-709 CTRP2 2.51 3.8642 2.506 23.56
G-402 CTRP2 2.5976 4.3175 2.5787 23.0263
MES-SA CTRP2 2.7571 3.4394 2.7571 21.9007
SK-UT-1 CTRP2 3.3566 9.8276 1.6208 24.2318
SW982 CTRP2 3.9685 5.6392 3.8753 14.1497
KYM-1 CTRP2 4.3376 5.8926 4.2208 11.7761
Tm87-16 CTRP2 4.5337 17.3863 -0.93 28.6725
SK-LMS-1 CTRP2 4.8442 9.6103 3.1837 14.5363
HT-1080 CTRP2 4.8508 12.7282 1.6622 20.3602
RKN CTRP2 8.531 9.6901 5.6764 0.0314
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H CTRP2 1.1534 6.0654 0.4811 30.18
MPP 89 CTRP2 2.5164 4.0254 2.5084 23.5307
NCI-H2452 CTRP2 3.13 5.5517 2.9835 19.9201
NCI-H2052 CTRP2 3.5675 9.712 1.8855 22.725
IST-Mes1 CTRP2 4.1005 9.9887 2.2858 19.8642
JL-1 CTRP2 8.2911 17.738 1.9478 12.8244
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VCaP CTRP2 2.584 4.1883 2.5354 17.7381
LNCaP clone FGC CTRP2 3.3345 5.1427 3.1506 12.8975
DU145 CTRP2 5.0832 11.4271 2.5153 16.6523
PaCa-3 CTRP2 7.1718 12.7839 2.7715 6.5488
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 CTRP2 4.1239 6.2421 3.8914 13.6155
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IM95 CTRP2 -0.2883 4.6371 -0.5396 42.7419
SNU-16 CTRP2 1.5867 2.5851 1.5862 24.6816
Fu97 CTRP2 1.8693 3.0414 1.8689 27.8166
ECC10 CTRP2 2.0361 3.7441 2.0272 26.7338
NCC-StC-K140 CTRP2 2.0376 3.4455 2.0352 26.7018
SNU-216 CTRP2 2.0529 4.5929 1.9819 26.8317
SNU-601 CTRP2 2.2097 3.5124 2.2079 25.5531
HGC-27 CTRP2 2.2274 4.1692 2.2042 25.5072
Hs 746.T CTRP2 2.2556 3.9737 2.2434 25.282
OCUM-1 CTRP2 2.3804 5.0329 2.2695 52.1786
SNU-1 CTRP2 2.5743 3.9748 2.5484 17.7243
KATO III CTRP2 3.0078 5.9137 2.7653 21.074
HuG1-N CTRP2 3.1673 6.3088 2.5517 15.8278
MKN74 CTRP2 3.2101 6.4229 2.5502 15.7087
KE-39 CTRP2 3.2208 5.5634 3.0796 19.2972
LMSU CTRP2 3.6474 8.5704 2.015 16.7784
SH-10-TC CTRP2 3.9347 6.4447 3.2908 10.5384
MKN7 CTRP2 4.9043 9.3586 2.7694 10.5229
NUGC-3 CTRP2 8.5647 10.1691 5.5268 0.1518
SNG-M CTRP2 3.4192 4.9815 3.3846 17.6058
SNU-685 CTRP2 4.5321 11.079 2.1775 19.2165
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW579 CTRP2 2.0439 4.4094 1.9928 26.8237
ML-1 [Human leukemia] CTRP2 2.3447 4.2971 2.3175 24.7389
FTC-238 CTRP2 2.4348 2.9769 2.4348 24.0475
TT2609-C02 CTRP2 4.1679 6.6116 3.8178 13.7591
FTC-133 CTRP2 6.421 10.4266 3.396 5.01
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-33 CTRP2 1.3014 2.5978 1.3011 31.5995
SCC-25 CTRP2 1.9054 4.0728 1.8762 27.6725
CAL-27 CTRP2 2.1846 3.0958 2.1845 25.715
BICR 22 CTRP2 2.3121 3.0337 2.312 19.5025
BICR 18 CTRP2 2.3589 3.919 2.3273 19.2819
YD-8 CTRP2 2.5156 4.5083 2.4793 23.6317
BICR 6 CTRP2 2.5967 5.1594 2.4813 23.3626
BICR 16 CTRP2 2.7515 5.1757 2.6452 22.3003
PE/CA-PJ15 CTRP2 3.3006 7.2097 2.3045 16.4798
PE/CA-PJ34 (clone C12) CTRP2 3.347 9.6113 1.228 20.7823
PE/CA-PJ49 CTRP2 3.3713 5.6083 3.2336 18.2828
BICR 31 CTRP2 3.5547 6.8146 2.7391 13.9367
HSC-2 CTRP2 4.364 6.85 3.9413 12.7339
HSC-4 CTRP2 4.45 9.8065 1.5242 11.5323
SCC-4 CTRP2 4.7629 10.639 2.6078 17.0201
SCC-9 CTRP2 5.0658 11.9721 2.2301 17.7876
FaDu CTRP2 5.1825 9.3308 3.6373 11.9072
BICR 56 CTRP2 5.4957 8.349 4.408 8.0162
PE/CA-PJ41 (clone D2) CTRP2 5.7241 15.0244 0.6089 17.6878
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BC-3C CTRP2 2.1354 4.6001 2.0687 26.2675
647V CTRP2 2.2038 3.3695 2.2031 25.5889
U-BLC1 CTRP2 2.2409 3.176 2.2407 25.3401
J82 CTRP2 2.7277 6.8453 2.1782 24.0362
UM-UC-1 CTRP2 3.787 6.9023 2.9349 12.4649
RT-112 CTRP2 4.0564 7.5027 2.3539 8.4452
SCaBER CTRP2 4.0817 7.0048 3.5806 14.9009
T24 CTRP2 4.6215 9.5352 3.0069 15.7741
HT-1197 CTRP2 4.8894 9.712 2.5802 11.3935
UM-UC-3 CTRP2 4.9595 8.6905 2.466 6.0972
KMBC-2 CTRP2 5.1638 8.2406 4.1474 9.8531
RT-4 CTRP2 7.6065 14.0324 3.2656 8.9209
HT-1376 CTRP2 8.5455 10.5007 5.4013 0.3463
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 2.6242 2.9578 2.6242 22.7855

References

1 ClinicalTrials.gov (NCT03824080) Evaluating the Efficacy and Safety of Bemcentinib in Patients With Myelodysplastic Syndromes. U.S. National Institutes of Health.
2 ClinicalTrials.gov (NCT03184571) Bemcentinib (BGB324) in Combination With Pembrolizumab in Patients With Advanced NSCLC. U.S. National Institutes of Health.
3 ClinicalTrials.gov (NCT03184558) Bemcentinib (BGB324) in Combination With Pembrolizumab in Patients With TNBC. U.S. National Institutes of Health.
4 AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells. J Thorac Oncol. 2020 Jun;15(6):973-999.