Details of the Drug

General Information of Drug (ID: DM0YZC6)

Drug Name
Fulvestrant
Synonyms
Faslodex; AstraZeneca brand of fulvestrant; Fulvestrant [USAN]; Ici 182780; ZD 182780; ZM 182780; Faslodex (TN); ZD-182780; ZD-9238; ZM-182780; Faslodex(ICI 182,780); Faslodex, ICI 182780, Fulvestrant; Fulvestrant (JAN/USAN/INN); (7R,13S,17S)-13-methyl-7-(9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol; (7R,8R,9S,13S,14S,17S)-13-methyl-7-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol; (7R,8S,9S,13S,14S,17S)-13-methyl-7-[9-(4,4,5,5,5-pentafluoropentylsulfinyl) nonyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol; (7alpha,17beta)-7-{9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl}estra-1,3,5(10)-triene-3,17-diol; 7-(9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl)estra-1,3,5(10)-triene-3,17-diol; 7alpha-(9-((4,4,5,5,5,-Pentafluoropentyl)sulfinyl)nonyl)estra-1,3,5(10)-triene-3,17beta-diol; 7alpha-(9-((4,4,5,5,5-Pentafluoropentyl)sulfinyl)nonyl)estra-1,3,5(10)-triene-3,17beta-diol; 7alpha-[9[(4,4,5,5,5-Pentafluropentyl)sulfinyl]nonyl]-estra-1,3,5(10)-triene-3, 17 beta diol; ICI
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Approved [1]
Therapeutic Class
Anticancer Agents
Affected Organisms
Humans and other mammals
ATC Code
L02BA03: Fulvestrant
L02BA: Anti-estrogens
L02B: HORMONE ANTAGONISTS AND RELATED AGENTS
L02: ENDOCRINE THERAPY
L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 3 Molecular Weight (mw) 606.8
Logarithm of the Partition Coefficient (xlogp) 9.2
Rotatable Bond Count (rotbonds) 14
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 9
ADMET Property
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 2: low solubility and high permeability [2]
Clearance
The drug present in the plasma can be removed from the body at the rate of 11.8 mL/min/kg [3]
Elimination
0.1% of drug is excreted from urine in the unchanged form [2]
Half-life
The concentration or amount of drug in body reduced by one-half in 40 days [3]
Metabolism
The drug is metabolized via the liver []
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 0.00023 micromolar/kg/day [4]
Unbound Fraction
The unbound fraction of drug in plasma is 0.01% [3]
Vd
The volume of distribution (Vd) of drug is 3-5 L/kg []
Water Solubility
The ability of drug to dissolve in water is measured as 0.001 mg/mL [2]
Chemical Identifiers
Formula
C32H47F5O3S
IUPAC Name
(7R,8R,9S,13S,14S,17S)-13-methyl-7-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
Canonical SMILES
C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)[C@@H](CC4=C3C=CC(=C4)O)CCCCCCCCCS(=O)CCCC(C(F)(F)F)(F)F
InChI
InChI=1S/C32H47F5O3S/c1-30-17-15-26-25-12-11-24(38)21-23(25)20-22(29(26)27(30)13-14-28(30)39)10-7-5-3-2-4-6-8-18-41(40)19-9-16-31(33,34)32(35,36)37/h11-12,21-22,26-29,38-39H,2-10,13-20H2,1H3/t22-,26-,27+,28+,29-,30+,41?/m1/s1
InChIKey
VWUXBMIQPBEWFH-WCCTWKNTSA-N
Cross-matching ID
PubChem CID
104741
ChEBI ID
CHEBI:31638
CAS Number
129453-61-8
UNII
22X328QOC4
DrugBank ID
DB00947
TTD ID
D0JO7Y
INTEDE ID
DR0756
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Estrogen receptor (ESR) TTZAYWL ESR1_HUMAN Antagonist [5]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4)
Main DME 		DE4LYSA CP3A4_HUMAN Substrate [6]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Substrate [7]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
2-aminoethanethiol dioxygenase (ADO) OTRLGQ7V AEDO_HUMAN Post-Translational Modifications [8]
2-oxoglutarate dehydrogenase complex component E1 (OGDH) OTHGTQWF ODO1_HUMAN Post-Translational Modifications [8]
24-hydroxycholesterol 7-alpha-hydroxylase (CYP39A1) OTBAJT4I CP39A_HUMAN Post-Translational Modifications [8]
26S proteasome complex subunit SEM1 (SEM1) OTASLBM1 SEM1_HUMAN Post-Translational Modifications [8]
26S proteasome non-ATPase regulatory subunit 14 (PSMD14) OTJWHMZ5 PSDE_HUMAN Gene/Protein Processing [9]
26S proteasome non-ATPase regulatory subunit 6 (PSMD6) OTX59EGK PSMD6_HUMAN Gene/Protein Processing [9]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1) OTNAZVKB 3BHS1_HUMAN Post-Translational Modifications [8]
3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D) OT1RWFV0 PDE4D_HUMAN Post-Translational Modifications [8]
3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH) OTCMMMIZ 3HIDH_HUMAN Post-Translational Modifications [8]
5-hydroxytryptamine receptor 5A (HTR5A) OTRKPCQV 5HT5A_HUMAN Post-Translational Modifications [8]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Breast cancer
ICD Disease Classification 2C60-2C65
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME UGT1A1 7.69E-01 1.91E-02 5.45E-02
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 9.85E-01 2.24E-02 7.33E-02
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 41 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1; GDSC2 5.7485 7.7313 2.6663 0.4465
EW-12 GDSC2 1.7005 3.9119 -0.7865 1.7108
U-CH2 GDSC2 2.262 3.846 -0.5152 0.3072
ES7 GDSC1; GDSC2 3.6633 7.978 1.2719 9.0013
SK-PN-DW GDSC1; GDSC2 3.8059 6.3097 2.2097 4.3152
ES1 GDSC1; GDSC2 3.8403 6.7092 2.0385 5.0527
NOS-1 [Human HNSCC] GDSC1; GDSC2 4.2475 7.2399 2.0703 4.2022
TC-71 GDSC1; GDSC2 4.3346 6.9716 2.2563 3.2312
HuO-3N1 GDSC1; GDSC2 4.3649 7.3923 2.0766 3.9881
CADO-ES1 GDSC1; GDSC2 4.403 6.7171 2.4183 2.4273
ES5 GDSC1; GDSC2 4.4817 7.7983 1.9609 4.3277
SaOS-2 GDSC1; GDSC2 4.4923 9.4293 1.1802 7.8571
CHSA0108 GDSC1; GDSC2 4.5798 8.522 1.6808 5.4354
ES6 GDSC1; GDSC2 4.7822 10.9687 0.6366 9.7856
ES8 GDSC1; GDSC2 4.925 9.2172 1.5793 5.3555
SJSA-1 GDSC1; GDSC2 4.9516 7.8024 2.2498 2.447
CHSA0011 GDSC1; GDSC2 5.0223 8.115 2.1503 2.7693
NY GDSC1; GDSC2 5.0865 12.2285 0.2399 10.9694
MG-63 GDSC1; GDSC2 5.1899 6.487 2.9004 0.1838
A-673 GDSC1; GDSC2 5.1917 9.7078 1.5202 5.2246
ES4 GDSC1; GDSC2 5.2805 7.47 2.5638 0.9832
EW-22 GDSC1; GDSC2 5.3252 9.5542 1.6748 4.3761
G-292 clone A141B1 GDSC1; GDSC2 5.3401 9.65 1.6398 4.505
CHSA8926 GDSC1; GDSC2 5.3649 7.0125 2.778 0.3585
EW-1 GDSC1; GDSC2 5.3742 8.2699 2.2764 1.8965
H-EMC-SS GDSC1; GDSC2 5.4274 9.1964 1.8984 3.3162
HOS GDSC1; GDSC2 5.4401 10.3483 1.378 5.4882
SK-ES-1 GDSC1; GDSC2 5.4455 7.3396 2.6885 0.5301
EW-24 GDSC1; GDSC2 5.5022 6.9058 2.8687 0.1558
EW-3 GDSC1; GDSC2 5.5166 10.2134 1.4881 4.914
EW-16 GDSC2 5.5233 8.1084 2.4192 1.268
EW-18 GDSC1; GDSC2 5.577 7.8334 2.5545 0.8153
HuO9 GDSC1; GDSC2 5.723 11.2963 1.1139 6.2205
CAL-72 GDSC1; GDSC2 6.0528 14.4011 -0.1403 10.9337
EW-7 GDSC1; GDSC2 6.0532 7.7483 2.7761 0.166
EW-13 GDSC1; GDSC2 6.0926 8.0882 2.6711 0.3162
EW-11 GDSC1; GDSC2 6.0981 9.4296 2.1541 1.6961
CAL-78 GDSC1; GDSC2 6.1342 8.6133 2.4942 0.6747
SW1353 CTRP2 9.4131 16.4135 3.3258 6.2625
U2OS GDSC1; GDSC2; CTRP2 10.582 21.6796 1.6075 10.2421
MHH-ES-1 GDSC1; GDSC2; CTRP2 10.8103 19.1111 2.9254 5.7884
⏷ Show the Full List of 41 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 177 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1; GDSC2 4.6366 6.7916 2.5215 1.716
SIG-M5 GDSC2 1.4749 2.4712 -0.323 0.1727
TALL-1 [Human adult T-ALL] GDSC2 1.8263 5.1323 -1.2513 3.9214
NK-92MI GDSC2 1.9599 3.7412 -0.5973 0.6947
MY-M12 GDSC2 2.0265 4.0885 -0.7031 1.0285
BC-3 GDSC2 2.2505 3.9669 -0.5631 0.4277
BC-1 GDSC1; GDSC2 2.4241 5.5018 1.4162 11.2168
BONNA-12 GDSC2 2.5326 4.9342 -0.8102 1.031
MHH-CALL-4 GDSC2 2.6236 4.628 -0.6577 0.5019
EoL-1 GDSC1; GDSC2 2.6989 5.7585 1.5521 9.8677
MOLT-16 GDSC1; GDSC2 2.8899 5.1498 2.0269 7.1611
SUP-M2 GDSC1; GDSC2 2.9708 6.5699 1.3968 9.9325
L-540 GDSC1; GDSC2 2.9788 5.8602 1.7566 8.2161
SUP-B8 GDSC1; GDSC2 3.204 6.9585 1.4045 9.3596
SU-DHL-6 GDSC1; GDSC2 3.3376 5.518 2.2369 5.1184
Sc-1 GDSC1 3.403 5.9679 2.0659 9.6018
MM1.S GDSC2 3.4252 7.3287 1.4039 8.8779
SR GDSC1; GDSC2 3.427 11.3814 -0.6206 17.8272
A3/Kawakami GDSC1; GDSC2 3.4544 4.8018 2.6893 2.7275
RL GDSC1; GDSC2 3.4759 6.3254 1.9465 6.203
SU-DHL-5 GDSC1; GDSC2 3.5141 5.4442 2.4164 3.8986
GDM-1 GDSC1; GDSC2 3.6544 5.5117 2.4903 3.2808
DND-41 GDSC1; GDSC2 3.666 5.7279 2.3922 3.7189
MOLT-13 GDSC1; GDSC2 3.6775 7.0614 1.7396 6.7718
AMO1 GDSC1; GDSC2 3.7225 5.8347 2.3818 3.6632
P32/ISH GDSC1; GDSC2 3.7634 5.7896 2.4339 3.3462
MOLM-16 GDSC1; GDSC2 3.7726 5.5259 2.5692 2.7029
Loucy GDSC1; GDSC2 3.7927 7.1064 1.8063 6.2323
RPMI-8866 GDSC1; GDSC2 3.8068 6.2442 2.2426 4.1601
HH [Human lymphoma] GDSC1; GDSC2 3.8404 6.5738 2.1053 4.7403
MC116 GDSC1; GDSC2 3.8569 5.3346 2.7189 1.8855
BV-173 GDSC1; GDSC2 3.864 5.9553 2.4251 3.2121
JVM-2 GDSC1; GDSC2 3.8791 6.8287 2.0084 5.122
NOMO-1 GDSC1; GDSC2 3.8928 7.0054 1.9316 5.4565
U-698-M GDSC1; GDSC2 3.91 6.8202 2.0354 4.94
KMS-12-BM GDSC2 3.9185 7.3544 1.7787 6.1239
ATN-1 GDSC1; GDSC2 3.9481 7.8398 1.5612 7.0857
Hs 445 GDSC1; GDSC2 3.9589 6.0016 2.4686 2.8555
MHH-PREB-1 GDSC1; GDSC2 3.9611 5.6199 2.652 2.0279
RPMI-8226 GDSC1; GDSC2 3.9789 6.9343 2.0297 4.8432
ALL-SIL GDSC1; GDSC2 4.003 7.2683 1.8836 5.4799
ALL-PO GDSC1; GDSC2 4.0095 7.5638 1.7432 6.1218
DoHH2 GDSC2 4.0221 7.8869 1.5934 6.7972
ST486 GDSC1; GDSC2 4.0307 7.2986 1.8889 5.4056
IM-9 GDSC1; GDSC2 4.0337 5.8541 2.5886 2.2017
GA-10 GDSC1; GDSC2 4.0416 5.8253 2.6071 2.1083
Karpas-620 GDSC1; GDSC2 4.049 6.8901 2.1015 4.3888
Jiyoye GDSC1; GDSC2 4.0846 6.5743 2.2791 3.5153
Kasumi-1 GDSC1; GDSC2 4.1263 6.8026 2.1978 3.8179
697 GDSC1; GDSC2 4.142 6.7216 2.2475 3.5667
GR-ST GDSC1; GDSC2 4.1443 7.6211 1.8132 5.5562
JSC-1 GDSC1; GDSC2 4.1495 7.7031 1.7769 5.7152
BE-13 GDSC1; GDSC2 4.1696 6.4279 2.4058 2.812
KMOE-2 GDSC1; GDSC2 4.1835 6.7563 2.2588 3.4499
Reh GDSC1; GDSC2 4.19 6.3896 2.4372 2.6427
SUP-HD1 GDSC1; GDSC2 4.2313 7.3294 2.0161 4.4754
OCI-AML-2 GDSC1; GDSC2 4.242 7.7349 1.8273 5.3231
KOPN-8 GDSC1; GDSC2 4.2488 6.6666 2.3445 2.9665
K-562 GDSC1; GDSC2 4.2608 7.0019 2.1934 3.6242
OCI-Ly19 GDSC1; GDSC2 4.2628 6.3427 2.505 2.2435
Daudi GDSC1; GDSC2 4.2694 6.4173 2.4746 2.366
SU-DHL-16 GDSC1; GDSC2 4.3324 6.5081 2.4715 2.2937
L-1236 GDSC1; GDSC2 4.3344 14.2676 -1.3317 18.577
MOLP-8 GDSC1; GDSC2 4.3502 6.379 2.5416 1.9731
NB4 GDSC1; GDSC2 4.3524 5.8544 2.7763 1.0293
JJN-3 GDSC1; GDSC2 4.3685 6.554 2.4724 2.2419
A4/Fukuda GDSC1; GDSC2 4.3775 6.3075 2.59 1.738
SCC-3 GDSC2 4.3856 9.6594 0.99 8.9129
JeKo-1 GDSC1; GDSC2 4.4544 6.4979 2.549 1.8143
Mono-Mac-6 GDSC1; GDSC2 4.457 10.3292 0.7134 10.0298
BALL-1 GDSC1; GDSC2 4.464 6.6371 2.4917 2.039
L-363 GDSC1; GDSC2 4.4738 10.746 0.5206 10.8555
NKM-1 GDSC1; GDSC2 4.477 8.4413 1.6492 5.7451
SU-DHL-8 GDSC1; GDSC2 4.4901 6.6223 2.5137 1.9164
SKM-1 GDSC1; GDSC2 4.4944 7.9728 1.8861 4.6441
DB GDSC1; GDSC2 4.4965 6.6152 2.5205 1.8806
MN-60 GDSC1; GDSC2 4.5153 6.3543 2.6468 1.3567
ML-2 GDSC1; GDSC2 4.5168 7.5033 2.1234 3.552
Karpas-299 GDSC1; GDSC2 4.5169 6.4448 2.608 1.5061
Karpas-231 GDSC1; GDSC2 4.5315 6.1328 2.7506 0.9551
TUR GDSC1; GDSC2 4.5442 8.162 1.8291 4.8228
BL-41 GDSC1; GDSC2 4.5663 6.1786 2.7489 0.9302
Ramos.2G6.4C10 GDSC1; GDSC2 4.5711 6.146 2.765 0.8701
RS4;11 GDSC1; GDSC2 4.58 6.6475 2.5536 1.6514
CA46 GDSC1; GDSC2 4.5922 9.2934 1.3171 7.0632
RPMI-6666 GDSC1; GDSC2 4.6008 7.5995 2.1318 3.3955
KY821 GDSC1; GDSC2 4.6362 6.4464 2.6713 1.1453
KMS-21-BM CTRP2 4.6558 10.5549 2.5483 17.5031
TK [Human B-cell lymphoma] GDSC1; GDSC2 4.7585 6.5282 2.6987 0.9416
WSU-NHL GDSC1; GDSC2 4.7929 9.303 1.4506 6.1325
HC-1 GDSC1; GDSC2 4.807 6.9281 2.5544 1.4132
DG-75 GDSC1; GDSC2 4.8135 8.4753 1.8569 4.2955
P30/OHK GDSC1; GDSC2 4.826 6.9146 2.5701 1.3372
VAL GDSC1; GDSC2 4.8431 7.9456 2.1212 3.1138
HAL-01 GDSC1; GDSC2 4.8452 7.4077 2.3654 2.1041
WSU-DLCL2 GDSC1; GDSC2 4.8548 9.9813 1.167 7.3035
MHH-CALL-2 GDSC1; GDSC2 4.8841 6.5718 2.7408 0.7109
WIL2 NS GDSC1; GDSC2 4.8936 6.8302 2.6399 1.0307
EB2 GDSC1; GDSC2 4.9193 7.8034 2.2309 2.5623
Karpas-1106P GDSC1; GDSC2 4.9221 6.9683 2.5964 1.1563
CCRF-CEM GDSC1; GDSC2 4.9246 6.9729 2.5958 1.1565
OCI-AML-3 GDSC1; GDSC2 4.9345 6.8285 2.6605 0.9292
OCI-AML-5 GDSC1; GDSC2 4.9507 5.921 3.0103 0.0821
MLMA GDSC1; GDSC2 4.9631 9.1614 1.6304 5.0734
SU-DHL-4 GDSC1; GDSC2 4.9656 6.4464 2.826 0.4244
LP-1 GDSC1; GDSC2 4.9694 6.8071 2.6858 0.8219
RC-K8 GDSC1; GDSC2 4.9758 6.9446 2.6328 0.9886
HL-60 GDSC1; GDSC2 5.0607 6.5366 2.8316 0.3662
CESS GDSC1; GDSC2 5.065 7.5494 2.4232 1.6505
ME1 GDSC1; GDSC2 5.0729 6.5384 2.8359 0.351
U266B1 GDSC1; GDSC2 5.0736 7.414 2.4855 1.4153
SU-DHL-10 GDSC1; GDSC2 5.0814 6.32 2.9189 0.1831
OCI-Ly7 GDSC1; GDSC2 5.0842 6.3518 2.9086 0.2
OCI-M1 GDSC1; GDSC2 5.0909 6.558 2.8359 0.3433
PL-21 GDSC1; GDSC2 5.111 7.4836 2.475 1.419
SUP-T1 GDSC1; GDSC2 5.1188 7.0098 2.6737 0.7568
Karpas-45 GDSC1; GDSC2 5.1409 6.8832 2.7332 0.5736
MEG-01 GDSC1; GDSC2 5.1487 8.1693 2.1981 2.4304
VL51 GDSC1; GDSC2 5.164 9.0686 1.8001 4.057
SUP-B15 GDSC2 5.204 6.8354 2.7784 0.4263
Farage GDSC1; GDSC2 5.2515 6.704 2.8461 0.2616
MOLT-4 GDSC1; GDSC2 5.2611 6.8744 2.7873 0.3805
ARH-77 GDSC1; GDSC2 5.2795 6.8091 2.8188 0.3057
CTV-1 GDSC1; GDSC2 5.2817 7.2087 2.6683 0.6712
CTB-1 GDSC1; GDSC2 5.2827 7.4596 2.569 0.9653
CMK GDSC1 5.2851 6.3791 2.972 0.1195
Raji GDSC1; GDSC2 5.2876 6.591 2.9001 0.1595
H9 GDSC1; GDSC2 5.2918 10.128 1.3871 5.6594
Namalwa GDSC1; GDSC2 5.2939 6.7262 2.8544 0.2326
EJM GDSC1; GDSC2 5.3006 7.177 2.6889 0.6043
NU-DUL-1 GDSC1; GDSC2 5.3031 6.6061 2.9004 0.1553
YT GDSC1; GDSC2 5.3139 7.0717 2.7349 0.4797
OPM-2 GDSC1; GDSC2 5.3273 6.9423 2.7888 0.35
RCH-ACV GDSC1; GDSC2 5.4041 7.5871 2.574 0.8671
KE-37 GDSC1; GDSC2 5.413 6.5013 2.975 0.0543
KG-1 GDSC1; GDSC2 5.4209 7.2749 2.7027 0.507
KE-97 CTRP2 5.5035 10.4399 3.381 12.2609
Karpas-422 GDSC1; GDSC2 5.5128 6.8245 2.9006 0.113
THP-1 GDSC1; GDSC2 5.5383 7.2697 2.7524 0.3458
QIMR-WIL GDSC1; GDSC2 5.5523 7.9465 2.4984 0.9961
Granta-519 GDSC1; GDSC2 5.6583 7.4659 2.728 0.3516
KMS-26 CTRP2 5.7286 9.4942 4.0497 9.0126
Ku812 GDSC1; GDSC2; CTRP2 5.7636 11.8479 2.9054 12.8294
SK-MM-2 GDSC1; GDSC2 5.8394 7.526 2.7755 0.2135
L-428 GDSC1; GDSC2 5.8847 7.5933 2.7687 0.2128
ROS-50 GDSC1; GDSC2 6.0156 7.8231 2.7363 0.23
LC4-1 GDSC1; GDSC2 6.0231 8.3493 2.5476 0.5982
CRO-AP2 GDSC1; GDSC2 6.1146 7.8546 2.7615 0.1727
KMS-11 GDSC1; GDSC2 6.3935 8.3227 2.7001 0.1969
SU-DHL-1 GDSC2; CTRP2 6.9231 18.0412 0.7616 18.1797
P31/FUJ GDSC1; GDSC2; CTRP2 6.9782 8.5791 5.4447 1.1148
JURL-MK1 GDSC1; GDSC2; CTRP2 7.0837 10.5815 4.5727 4.1669
EM-2 GDSC1; GDSC2; CTRP2 7.1293 10.4422 4.6707 3.7365
P12-Ichikawa GDSC1; GDSC2; CTRP2 7.1631 11.2242 4.3172 5.028
MOLM-13 GDSC1; GDSC2; CTRP2 7.4204 11.2103 4.4985 4.0054
HEL GDSC1; GDSC2; CTRP2 7.455 9.3698 5.358 0.9841
HT GDSC1; GDSC2; CTRP2 7.5242 8.6722 5.6671 0.1867
Ki-JK CTRP2 7.5337 9.3575 5.4028 0.8505
JVM-3 GDSC1; GDSC2; CTRP2 7.607 10.4899 4.9493 2.1749
NCI-H929 GDSC1; GDSC2; CTRP2 7.7053 10.685 4.9185 2.1822
KHM-1B CTRP2 7.789 9.8364 5.3295 0.8881
EHEB GDSC1; CTRP2 7.8101 10.061 5.2468 1.1205
NALM-6 GDSC1; GDSC2; CTRP2 7.842 13.8283 3.5295 7.0671
PF-382 GDSC1; GDSC2; CTRP2 7.8774 10.365 5.1527 1.2781
KMS-27 CTRP2 7.916 9.8415 5.3866 0.6521
CML-T1 GDSC1; GDSC2; CTRP2 7.9307 15.9129 2.5802 10.4301
DEL GDSC1; GDSC2; CTRP2 7.937 12.0232 4.4464 3.5834
MV4-11 GDSC1; GDSC2; CTRP2 8.0459 14.8924 3.1569 8.167
KCL-22 GDSC1; GDSC2; CTRP2 8.0807 12.023 4.5333 3.1234
NCO2 CTRP2 8.1169 10.0531 5.3926 0.5338
Jurkat GDSC1; GDSC2; CTRP2 8.6441 17.5546 2.2854 10.462
HDLM-2 GDSC1; GDSC2; CTRP2 8.8383 13.1216 4.4735 2.6041
KMM-1 CTRP2 9.1182 11.3939 5.3002 0.346
LAMA-84 GDSC1; GDSC2; CTRP2 9.423 18.4317 2.3894 9.0894
RPMI-8402 GDSC1; GDSC2; CTRP2 9.8127 18.1618 2.764 7.3585
Peer CTRP2 10.2418 21.3697 1.5339 11.4712
KM-H2 GDSC1; GDSC2; CTRP2 10.9572 20.431 2.4158 7.268
⏷ Show the Full List of 177 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-50 GDSC1; GDSC2 4.344 8.8286 1.3669 7.2642
FLO-1 GDSC1; GDSC2 4.4781 10.1509 0.8165 9.5291
OACM5.1 C GDSC1; GDSC2 4.5913 7.2191 2.3021 2.6744
HCE-4 GDSC1; GDSC2 4.6691 7.7106 2.1229 3.3392
ESO-51 GDSC1; GDSC2 4.9266 9.2673 1.5567 5.4532
OACP4 C GDSC1; GDSC2 4.9602 7.7817 2.2641 2.3796
ESO-26 GDSC1; GDSC2 5.1661 7.0995 2.6595 0.7682
TE-12 GDSC1; GDSC2 5.3434 8.9788 1.9476 3.2152
KYAE-1 GDSC1; GDSC2 5.3892 6.8786 2.8362 0.2361
KYSE-220 GDSC1; GDSC2 5.4394 7.8888 2.4688 1.17
SK-GT-4 GDSC1; GDSC2 5.6353 13.5378 -0.0102 11.082
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1; GDSC2 4.8672 8.2035 2.0172 3.5252
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MHH-NB-11 GDSC2 1.6479 3.6315 -0.6957 1.3535
KP-N-RT-BM-1 GDSC2 1.9407 4.1961 -0.7862 1.4484
KP-N-YS GDSC2 2.5137 4.4882 -0.6499 0.5338
SK-N-MC-IXC GDSC1; GDSC2 3.4388 5.9908 2.0836 5.6305
KP-N-YN GDSC1; GDSC2 3.7236 7.1306 1.7411 6.6736
CHP-212 GDSC1; GDSC2 3.9917 8.1476 1.442 7.5597
Kelly GDSC1; GDSC2 4.0393 6.458 2.304 3.4754
NB1 GDSC1; GDSC2 4.2402 6.8819 2.2368 3.4606
SJNB-13 GDSC1; GDSC2 4.2442 9.0927 1.1645 8.3742
NH-12 GDSC1; GDSC2 4.5228 7.0646 2.3315 2.6393
SJNB-6 GDSC1; GDSC2 4.5262 7.4371 2.1605 3.3756
NB69 GDSC1; GDSC2 4.6181 12.9484 -0.4584 14.7125
LA-N-6 GDSC1; GDSC2 4.6434 8.9357 1.5254 6.035
SJNB-12 GDSC1; GDSC2 4.6585 10.0814 0.9809 8.4692
GI-ME-N GDSC1; GDSC2 4.6707 8.7829 1.6172 5.5776
SJNB-14 GDSC1; GDSC2 4.6793 11.2304 0.434 10.858
TGW GDSC1; GDSC2 4.8058 7.4447 2.3265 2.3062
CHP-134 GDSC2 4.9938 6.4665 2.8302 0.4001
NB(TU)1 GDSC1; GDSC2 5.1661 6.8636 2.7517 0.5112
SJNB-5 GDSC1; GDSC2 5.1717 7.8723 2.3406 1.8548
IMR-5 GDSC1; GDSC2 5.1927 10.8185 0.9948 7.5237
SJNB-7 GDSC1; GDSC2 5.2067 7.2009 2.6377 0.8066
SK-N-SH GDSC1; GDSC2 5.2392 9.142 1.812 3.908
GOTO GDSC1; GDSC2 5.2929 7.8706 2.4042 1.5089
SK-N-DZ GDSC1; GDSC2 5.3118 6.8923 2.8011 0.3302
SJNB-10 GDSC1; GDSC2 5.3651 7.0778 2.7538 0.4119
SK-N-FI GDSC1; GDSC2 5.3685 7.6478 2.5331 1.0166
SiMa GDSC1; GDSC2 5.5056 10.538 1.3308 5.5993
SJNB-17 GDSC1; GDSC2 5.6822 7.5554 2.7047 0.3905
SK-N-BE(2)-M17 GDSC1; GDSC2 5.754 7.6533 2.6972 0.379
CHP-126 GDSC1; GDSC2 5.9204 7.6025 2.7785 0.1902
SK-N-AS GDSC1; GDSC2 7.4702 16.2746 -0.1106 8.779
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1; GDSC2 5.0301 8.7512 1.8643 3.9617
HuH-28 CTRP2 7.5516 8.8998 5.5933 0.3363
SNU-478 CTRP2 7.659 9.9092 5.2338 1.2818
SNU-1196 CTRP2 8.0534 9.7542 5.4795 0.3711
SNU-308 CTRP2 8.2067 9.9467 5.4701 0.3332
SNU-1079 CTRP2 8.4361 16.5386 2.632 10.1133
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UACC-812 GDSC2 1.5506 4.4772 -1.1164 3.6293
YMB-1-E GDSC2 3.3903 5.4374 -0.658 0.2425
Hs 578T GDSC1; GDSC2 3.4409 7.6999 1.2313 9.6565
Evsa-T GDSC1; GDSC2 3.6189 6.1884 2.1281 5.0536
OCUB-M GDSC1; GDSC2 3.6433 6.1982 2.1421 4.9398
DU4475 GDSC1; GDSC2 4.1402 6.0025 2.5867 2.0582
AU565 GDSC1; GDSC2 4.2016 7.6691 1.8307 5.3761
HCC1569 GDSC1; GDSC2 4.3629 8.4654 1.5576 6.3555
EFM-192A GDSC1; GDSC2 4.3983 8.3826 1.6228 5.9969
HCC1187 GDSC1; GDSC2 4.4771 6.591 2.5201 1.9054
HCC2157 GDSC1; GDSC2 4.4893 6.4907 2.5721 1.6796
BT-549 GDSC1; GDSC2 4.6656 8.49 1.7536 4.9734
JIMT-1 GDSC1; GDSC2 4.6817 6.7639 2.5584 1.5236
HCC202 GDSC1 4.757 7.4596 2.2913 4.1611
HCC1419 GDSC1; GDSC2 4.7874 6.6726 2.6528 1.0753
COLO 824 GDSC1; GDSC2 4.8375 8.8185 1.7108 4.9041
HCC1599 GDSC1; GDSC2 4.8481 8.2526 1.9827 3.6996
HCC1500 GDSC1; GDSC2 4.8496 13.5702 -0.5915 14.7998
HCC70 GDSC1; GDSC2 4.858 9.7521 1.2794 6.7952
HCC38 GDSC1; GDSC2 4.9558 9.0793 1.6644 4.935
ZR-75-30 GDSC1; GDSC2 4.9611 14.1213 -0.78 15.3201
BT-20 GDSC1; GDSC2 5.0052 7.1783 2.5501 1.2466
MDA-MB-157 GDSC1; GDSC2 5.0579 8.7574 1.8786 3.8634
MFM-223 GDSC1; GDSC2 5.1459 10.6373 1.05 7.3551
MDA-MB-468 GDSC1; GDSC2 5.2078 10.8616 0.9843 7.5461
HCC1143 GDSC1; GDSC2 5.2447 8.5494 2.0833 2.7806
MDA-MB-361 GDSC1; GDSC2 5.2452 20.3871 -3.6656 23.8031
MRK-nu-1 GDSC1; GDSC2 5.319 6.9426 2.7854 0.3609
HCC2218 GDSC1; GDSC2 5.3358 8.26 2.2604 1.9933
MDA-MB-436 GDSC1; GDSC2 5.3556 11.6507 0.7062 8.5214
MDA-MB-330 GDSC1; GDSC2 5.4629 10.8159 1.1736 6.336
MDA-MB-175-VII GDSC1; GDSC2 5.6105 7.4122 2.7288 0.3675
UACC-893 GDSC1; GDSC2 5.6293 7.7631 2.6047 0.6495
MDA-MB-231 GDSC1; GDSC2 5.7764 7.3648 2.8088 0.1795
EFM-19 GDSC1; GDSC2 5.815 16.0612 -1.1085 15.014
HCC1428 GDSC1; GDSC2 5.945 15.2064 -0.6017 12.9096
CAL-85-1 GDSC1; GDSC2 6.1532 8.4151 2.576 0.48
BT-474 GDSC1; GDSC2 6.3422 15.1973 -0.3265 11.2143
MCF-7 GDSC1; GDSC2; CTRP2 6.452 35.7644 -8.4774 35.1408
MDA-MB-453 GDSC1; GDSC2 6.6209 15.7929 -0.425 11.1681
MDA-MB-415 GDSC1; GDSC2 6.8129 18.952 -1.8097 15.7771
T-47D GDSC1; GDSC2 6.8469 22.9416 -3.7278 21.2367
CAL-148 GDSC2; CTRP2 6.9941 8.5985 5.4451 1.0986
KPL-1 CTRP2 7.2279 15.3136 2.3554 13.0676
CAL-120 GDSC1; GDSC2; CTRP2 7.6437 8.8034 5.666 0.1555
HMC-1-8 CTRP2 7.6701 8.8115 5.6731 0.1482
BT-483 GDSC1; GDSC2 7.9075 21.2099 -2.1496 15.1998
HCC1937 GDSC1; GDSC2; CTRP2 7.9764 13.9321 3.5713 6.7324
HCC1395 GDSC1; GDSC2; CTRP2 7.9954 10.3257 5.2282 0.9769
HCC1806 GDSC1; GDSC2; CTRP2 8.0515 11.9178 4.5639 3.0478
HDQ-P1 GDSC1; GDSC2; CTRP2 8.2648 9.8766 5.5184 0.2168
CAL-51 GDSC1; GDSC2; CTRP2 8.5555 9.9382 5.6024 0.072
HCC1954 GDSC1; GDSC2; CTRP2 12.5515 24.886 1.3352 8.9392
CAMA-1 GDSC1; GDSC2; CTRP2 14.1564 36.5726 -3.1039 18.0192
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 7.8786 9.0944 5.6509 0.1316
Cancer Drug Sensitivity Data Curated from 60 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hs 683 GDSC1; GDSC2 3.5475 5.0662 2.6299 2.8261
D-245MG GDSC2 3.6058 6.1326 -0.8218 0.4911
D-566MG GDSC1; GDSC2 3.6895 5.9611 2.2947 4.1325
MOG-G-UVW GDSC1; GDSC2 3.9288 5.7965 2.5465 2.55
D-247MG GDSC1; GDSC2 4.0419 8.0633 1.5212 7.0966
KNS-42 GDSC1; GDSC2 4.0505 6.0705 2.4971 2.5838
MOG-G-CCM GDSC1; GDSC2 4.1261 8.5022 1.3676 7.6546
LNZTA3WT4 GDSC1 4.1375 9.4718 0.8975 15.5699
KNS-81-FD GDSC1; GDSC2 4.3246 7.5475 1.9751 4.5106
D-263MG GDSC1; GDSC2 4.4403 7.2739 2.1821 3.4041
D-423MG GDSC1; GDSC2 4.4527 7.2545 2.1992 3.3109
Onda 10 GDSC1; GDSC2 4.4799 7.1425 2.2688 2.9678
PFSK-1 GDSC1; GDSC2 4.492 7.1019 2.2952 2.8366
DK-MG GDSC1; GDSC2 4.5399 6.5701 2.5654 1.6491
YKG-1 GDSC1; GDSC2 4.5466 7.1331 2.3145 2.6804
8-MG-BA GDSC1; GDSC2 4.7134 6.9635 2.4883 1.7627
Onda 11 GDSC1; GDSC2 4.788 6.9706 2.5259 1.5389
SNB-75 GDSC1; GDSC2 4.7983 7.7373 2.1896 2.8831
YH-13 GDSC1; GDSC2 4.8262 8.9268 1.6522 5.181
SW1088 GDSC1; GDSC2 4.9696 9.0189 1.7016 4.7516
KINGS-1 GDSC1; GDSC2 5.0322 9.9509 1.3015 6.4221
D-392MG GDSC1; GDSC2 5.0698 7.4209 2.4805 1.4364
D-336MG GDSC1; GDSC2 5.1149 7.8163 2.3344 1.9354
D-502MG GDSC1; GDSC2 5.1563 7.5806 2.4572 1.442
GI-1 GDSC1; GDSC2 5.2323 7.6121 2.4821 1.2895
LN-405 GDSC1; GDSC2 5.2562 8.0694 2.3004 1.922
SF539 GDSC1; GDSC2 5.3437 7.3052 2.6579 0.6639
M059J GDSC1; GDSC2 5.5218 7.8275 2.532 0.9155
SK-MG-1 GDSC1; GDSC2 5.5349 8.228 2.3755 1.404
D283 Med GDSC1; GDSC2 5.5491 7.1152 2.8124 0.2308
SW1783 GDSC1; GDSC2 5.56 8.0252 2.4704 1.077
D-542MG GDSC1; GDSC2 5.7146 7.4918 2.7405 0.3081
KS-1 [Human Krukenberg tumour] GDSC1; GDSC2 5.7224 8.9173 2.1808 1.9208
AM-38 GDSC1; GDSC2 5.7297 8.0908 2.5214 0.8177
DBTRG-05MG GDSC1; GDSC2 5.759 8.7881 2.2534 1.6352
U-118MG GDSC1; GDSC2 5.8794 7.561 2.778 0.2003
42-MG-BA GDSC1; GDSC2 5.8871 13.4636 0.1967 9.8306
A-172 GDSC1; GDSC2 5.9028 7.9882 2.6332 0.4561
GaMG GDSC1; GDSC2 6.1155 14.2118 -0.0077 10.3059
SF268 GDSC1; GDSC2 6.1417 11.8898 1.0975 5.7256
KALS-1 GDSC1; GDSC2 6.2231 11.648 1.2561 4.9741
Becker GDSC1; GDSC2 6.2299 14.3841 -0.0138 10.1548
T98G GDSC1; GDSC2 6.3465 8.5327 2.6087 0.35
H4 GDSC1; GDSC2 6.8304 17.9019 -1.292 14.0075
U-87MG ATCC GDSC1; GDSC2; CTRP2 7.1945 8.9197 5.4143 1.0196
LN-18 GDSC1; GDSC2; CTRP2 7.2079 8.2551 5.6937 0.2485
SNU-489 CTRP2 7.2983 8.4947 5.6404 0.3458
SNU-466 CTRP2 7.5778 8.7372 5.6644 0.1872
CAS-1 GDSC1; GDSC2; CTRP2 7.5796 9.0053 5.5649 0.3635
SNU-738 CTRP2 7.7203 9.1365 5.5741 0.3077
SNU-201 CTRP2 7.7836 9.1248 5.6039 0.2289
SF295 GDSC1; GDSC2; CTRP2 7.811 12.8472 3.9787 5.438
NMC-G1 GDSC1; GDSC2; CTRP2 7.9814 9.2548 5.6325 0.1258
LN-229 GDSC1; GDSC2; CTRP2 8.226 9.8538 5.5116 0.2373
GB-1 GDSC1; GDSC2; CTRP2 8.5041 10.1592 5.508 0.1763
SF126 GDSC1; GDSC2; CTRP2 8.7837 14.9676 3.6066 5.612
ONS-76 GDSC1; GDSC2; CTRP2 9.518 17.3632 2.9514 7.0558
U-251MG GDSC1; GDSC2 9.7589 20.5035 -0.6828 8.0958
Daoy GDSC1; GDSC2; CTRP2 12.0401 21.0096 2.7701 5.167
SNU-1105 CTRP2 13.8794 28.2596 0.5874 10.1993
⏷ Show the Full List of 60 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC24TKB GDSC1; GDSC2 5.2701 7.9041 2.3784 1.6215
TGBC1TKB GDSC1; GDSC2 5.3956 6.8808 2.8378 0.2314
ETK-1 GDSC1; GDSC2 5.9809 8.6895 2.3981 1.0156
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MFE-319 GDSC1; GDSC2 4.2948 7.2758 2.0852 4.0589
MFE-280 GDSC1; GDSC2 4.5036 7.4328 2.148 3.4626
ESS-1 GDSC1; GDSC2 4.9031 6.9353 2.6008 1.1576
AN3-CA GDSC1; GDSC2 5.078 7.5194 2.4429 1.5655
EN GDSC1; GDSC2 5.3595 7.0202 2.7729 0.3716
HEC-265 CTRP2 7.6291 8.918 5.6184 0.2538
HEC-59 CTRP2 7.762 9.7382 5.3567 0.8276
HEC-251 CTRP2 7.8082 9.4162 5.505 0.4193
HEC-6 CTRP2 7.9423 12.6418 4.1615 4.9081
HEC-108 CTRP2 7.9987 9.1253 5.6834 0.0747
KLE GDSC1; GDSC2; CTRP2 8.2621 10.67 5.2147 0.8497
MFE-296 GDSC1; GDSC2 8.6393 19.3529 -0.8152 9.8322
HEC-1-B CTRP2 9.8818 20.578 1.673 11.4852
JHUEM-2 CTRP2 10.5035 20.3694 2.1691 9.0377
RL95-2 GDSC1; GDSC2; CTRP2 10.8001 20.2636 2.3985 7.4864
Ishikawa (Heraklio) 02 ER- CTRP2 7.2875 8.3458 5.6926 0.2342
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 35 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VMRC-RCW GDSC2 2.3239 4.0944 -0.5808 0.4399
LB2241-RCC GDSC1; GDSC2 3.7748 7.1693 1.7614 6.4779
SW13 GDSC1; GDSC2 4.0062 7.0896 1.9735 5.0561
LB1047-RCC GDSC1; GDSC2 4.1045 6.8014 2.1833 3.9198
VMRC-RCZ GDSC1; GDSC2 4.2528 6.2764 2.5295 2.1517
A-704 GDSC1; GDSC2 4.2679 6.5958 2.3903 2.7365
KTCTL-140 GDSC1; GDSC2 4.3667 7.4377 2.0562 4.0774
Caki-1 GDSC1; GDSC2 4.4158 6.5363 2.5089 2.0272
SW156 GDSC1; GDSC2 4.4338 7.1824 2.221 3.2424
LB996-RCC GDSC1; GDSC2 4.4918 6.8991 2.3887 2.4364
RXF 393L GDSC1; GDSC2 4.5234 7.5571 2.1024 3.6351
UO-31 GDSC1; GDSC2 4.6124 8.7682 1.5848 5.817
KTCTL-26A GDSC1; GDSC2 4.7227 7.1351 2.4174 2.0346
KTCTL-1M GDSC1; GDSC2 4.7508 7.4908 2.2736 2.5909
HA7-RCC GDSC1; GDSC2 4.8099 7.5341 2.2887 2.4563
BB65-RCC GDSC1; GDSC2 4.8468 8.0152 2.0915 3.2351
NCC010 GDSC1; GDSC2 4.8973 7.0644 2.5432 1.3684
A-498 GDSC1; GDSC2 4.9029 7.373 2.4128 1.8542
KTCTL-21 GDSC1; GDSC2 4.9481 7.7491 2.2717 2.3628
RCC10RGB GDSC1; GDSC2 4.9664 10.4948 0.9962 7.8812
CAL-54 GDSC1; GDSC2 5.1973 16.3458 -1.7008 18.1837
KMRC-1 GDSC1; GDSC2 5.2711 8.5697 2.0892 2.7268
KTCTL-13 GDSC1; GDSC2 5.3797 7.3742 2.6469 0.6737
SN12C GDSC1; GDSC2 5.4802 12.571 0.349 9.8451
TK-10 GDSC1; GDSC2 5.5649 10.2784 1.4877 4.8515
KTCTL-195 GDSC1; GDSC2 5.5906 7.7132 2.6073 0.6632
ACHN GDSC1; GDSC2 5.8862 11.0982 1.3061 5.1925
786-O GDSC1; GDSC2 6.0048 13.7277 0.1493 9.8418
NCC021 GDSC1; GDSC2 6.1654 8.1552 2.6748 0.2888
TUHR4TKB CTRP2 7.5251 9.2295 5.4513 0.7143
BFTC-909 GDSC1; GDSC2; CTRP2 7.5789 18.5483 1.0207 16.2748
KMRC-20 GDSC1; GDSC2; CTRP2 8.1015 9.7531 5.4994 0.2947
769-P GDSC1; GDSC2; CTRP2 8.3138 14.025 3.7497 5.6522
OS-RC-2 GDSC1; GDSC2; CTRP2 8.4186 9.9613 5.5459 0.1466
SNU-1272 CTRP2 8.8044 17.0824 2.6215 9.6278
⏷ Show the Full List of 35 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 51 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-283 GDSC2 1.596 3.2645 -0.5714 0.8787
LoVo GDSC1; GDSC2 3.5798 6.496 1.9444 5.9999
SNU-175 GDSC2 3.6401 5.7953 2.3393 4.0164
HCT 15 GDSC1; GDSC2 4.0437 7.3995 1.849 5.5678
HT-55 GDSC1; GDSC2 4.3178 6.4489 2.4899 2.2347
SNU-C1 GDSC1; GDSC2 4.5144 8.0748 1.8508 4.7719
LS1034 GDSC1; GDSC2 4.6549 8.3925 1.793 4.814
NCI-H716 GDSC1; GDSC2 4.7417 7.3082 2.3508 2.283
NCI-H508 GDSC1; GDSC2 4.7823 8.9602 1.6073 5.4478
SW1116 GDSC1; GDSC2 4.7919 6.9172 2.5511 1.4403
SW1463 GDSC1; GDSC2 4.8831 7.493 2.3489 2.1273
LS123 GDSC1; GDSC2 4.9051 10.9768 0.7202 9.2046
CCK-81 GDSC1; GDSC2 4.9558 11.8275 0.342 10.762
SNU-61 GDSC1; GDSC2 4.9692 6.7087 2.7253 0.7008
SNU-C5 GDSC1; GDSC2 4.9983 7.6166 2.3583 1.9648
SW626 GDSC1; GDSC2 5.0438 11.7605 0.4373 10.1989
CW-2 GDSC1; GDSC2 5.0629 9.0821 1.7311 4.4908
T84 GDSC1; GDSC2 5.0734 7.6002 2.4058 1.7073
SNU-407 GDSC1; GDSC2 5.0761 8.0386 2.2153 2.4431
RCM-1 [Human ESC] GDSC1; GDSC2 5.143 9.2224 1.716 4.4455
C2BBe1 GDSC1; GDSC2 5.1672 8.6596 1.989 3.2585
SW1417 GDSC1; GDSC2 5.2611 7.3651 2.597 0.8936
DiFi GDSC1; GDSC2 5.3085 8.4289 2.1722 2.3582
GP5d GDSC1; GDSC2 5.3165 10.8975 1.0396 7.1355
CL-11 GDSC1; GDSC2 5.4606 7.9087 2.4708 1.1476
NCI-H747 GDSC1; GDSC2 5.4824 7.3202 2.7112 0.4585
COLO 678 GDSC1; GDSC2 5.5531 11.2067 1.0478 6.7463
CaR-1 GDSC1; GDSC2 5.5571 7.3031 2.7476 0.3487
KM12 GDSC1; GDSC2 5.5689 7.0947 2.8271 0.2016
SNU-1040 GDSC1; GDSC2 5.6837 7.2793 2.8047 0.2766
SW948 GDSC1; GDSC2 5.6882 7.2278 2.8243 0.1771
SW837 GDSC1; GDSC2 5.7392 12.3702 0.619 8.2973
RKO GDSC1; GDSC2 5.8352 12.0558 0.8297 7.2648
HCC2998 GDSC1; GDSC2 5.9506 12.0613 0.9004 6.8031
COLO 320HSR GDSC1; GDSC2 6.0738 7.6999 2.8 0.1336
SW620 GDSC1; GDSC2 6.37 12.5494 0.933 6.1046
MDST8 GDSC1; GDSC2 7.2777 15.4896 0.1334 8.1015
DLD-1 CTRP2 7.5715 8.665 5.688 0.1507
LS513 GDSC1; GDSC2; CTRP2 7.5786 8.9357 5.591 0.3297
SK-CO-1 GDSC1; GDSC2; CTRP2 7.5975 9.2729 5.4677 0.5839
HCT 116 GDSC1; GDSC2; CTRP2 7.6676 9.1825 5.5345 0.3906
SNU-C2A CTRP2 7.7202 11.2478 4.6712 3.2261
COLO205 GDSC1; GDSC2; CTRP2 7.7625 8.9971 5.6418 0.1612
LS411N GDSC1; GDSC2; CTRP2 7.7764 9.1296 5.5993 0.2243
SNU-C2B GDSC1; GDSC2 7.8051 15.4353 0.4675 6.1933
LS180 GDSC1; GDSC2; CTRP2 7.8123 9.9197 5.3065 0.8805
HT115 GDSC1; GDSC2; CTRP2 7.9301 9.5786 5.4946 0.365
OUMS-23 CTRP2 7.9305 8.8408 5.755 0.029
HT-29 GDSC1; GDSC2; CTRP2 7.9311 9.1267 5.6588 0.1044
SNU-81 GDSC1; GDSC2; CTRP2 8.3804 9.9355 5.5409 0.16
SW48 GDSC1; GDSC2; CTRP2 8.9596 20.7827 0.9408 14.4276
⏷ Show the Full List of 51 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1; GDSC2 5.7521 8.1989 2.489 0.8956
Cancer Drug Sensitivity Data Curated from 17 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-398 GDSC1; GDSC2 3.4688 6.1857 2.0105 5.914
JHH-6 GDSC1; GDSC2 3.9108 8.3735 1.2686 8.5231
HLE GDSC1; GDSC2 3.9279 6.7251 2.0952 4.6294
JHH-1 GDSC1; GDSC2 3.9485 6.4945 2.2227 4.0018
HuH-1 GDSC1; GDSC2 4.359 8.512 1.5322 6.4791
JHH-4 GDSC1; GDSC2 4.4828 10.4096 0.6928 10.0743
Huh-7 GDSC1; GDSC2 4.5345 8.0062 1.8969 4.5333
JHH-2 GDSC1; GDSC2 4.795 8.685 1.7462 4.8108
SK-HEP-1 GDSC1; GDSC2 4.903 7.3429 2.426 1.8032
SNU-387 GDSC1; GDSC2 5.4022 7.757 2.5048 1.0819
JHH-7 GDSC1; GDSC2 5.5866 12.2023 0.5977 8.622
Hep-G2/C3A GDSC1; GDSC2 5.7133 6.9722 2.9204 0.0659
SNU-449 GDSC1; GDSC2 5.886 7.9795 2.6298 0.4704
SNU-423 GDSC1; GDSC2 6.2477 13.7636 0.2916 8.8965
Li-7 CTRP2 7.9403 11.7419 4.5777 3.3235
Hep 3B2.1-7 GDSC1; GDSC2; CTRP2 8.1577 9.4392 5.6324 0.096
SNU-182 CTRP2 9.654 22.635 0.5307 15.4177
⏷ Show the Full List of 17 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 197 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H64 GDSC2 1.1958 2.478 -0.4409 0.7098
NCI-H2171 GDSC2 1.2712 2.7363 -0.51 0.927
HCC33 GDSC2 1.7999 3.2214 -0.4682 0.39
NCI-H2196 GDSC2 1.935 3.3439 -0.46 0.3073
COR-L303 GDSC2 2.2216 3.8699 -0.5391 0.3798
NCI-H510A GDSC2 2.5414 4.1003 -0.5016 0.1953
NCI-H748 GDSC2 2.5557 4.5159 -0.6434 0.4962
NCI-H740 GDSC2 2.6642 5.0071 -0.7821 0.8453
NCI-H1703 GDSC1; GDSC2 2.7366 9.0632 -0.05 17.0739
NCI-H1963 GDSC2 3.2294 7.7289 1.0409 11.0103
RERF-LC-MS GDSC1; GDSC2 3.2794 6.3232 1.7858 7.3869
NCI-H1341 GDSC1; GDSC2 3.4977 5.7435 2.2543 4.6992
NCI-H1836 GDSC1; GDSC2 3.6501 5.6067 2.4402 3.5238
NCI-H1688 GDSC1; GDSC2 3.873 6.3996 2.2147 4.1709
LXF 289 GDSC1; GDSC2 3.9065 9.704 0.604 11.5835
NCI-H1944 GDSC1; GDSC2 3.9067 6.0583 2.4052 3.2315
NCI-H2595 GDSC1; GDSC2 3.9316 9.2525 0.8481 10.4244
NCI-H2172 GDSC1; GDSC2 3.9418 8.6496 1.1554 8.9887
NCI-H1563 GDSC1; GDSC2 3.9966 6.0293 2.4809 2.7401
PaCa-3 GDSC1; GDSC2 4.0227 8.2184 1.4303 7.5558
NCI-H3122 GDSC1; GDSC2 4.0332 6.4704 2.2938 3.532
NCI-H2122 GDSC1; GDSC2 4.0496 6.6435 2.2215 3.8357
LK-2 GDSC1; GDSC2 4.0505 9.1786 0.9764 9.6037
LCLC-97TM1 GDSC1; GDSC2 4.06 6.4398 2.3269 3.3372
NCI-H647 GDSC1; GDSC2 4.0909 7.0875 2.0351 4.6234
Lu-139 GDSC1; GDSC2 4.0938 6.0663 2.5274 2.3846
NCI-H1770 GDSC1; GDSC2 4.0954 6.5316 2.307 3.3709
NCI-H3255 GDSC1; GDSC2 4.1294 6.7873 2.2073 3.7695
EMC-BAC-2 GDSC1; GDSC2 4.1307 6.3486 2.4179 2.8163
NCI-H290 GDSC1; GDSC2 4.1529 8.0417 1.6136 6.4653
ChaGo-K-1 GDSC1; GDSC2 4.1785 7.6224 1.837 5.3867
NCI-H2023 GDSC1; GDSC2 4.2372 7.4532 1.9604 4.7203
NCI-H2369 GDSC1; GDSC2 4.2398 7.5771 1.9022 4.9826
A-549 GDSC1; GDSC2 4.2669 10.4749 0.4992 11.3416
NCI-H2029 GDSC1; GDSC2 4.3092 6.1045 2.6419 1.6072
RERF-LC-KJ GDSC1; GDSC2 4.3155 6.792 2.3285 2.9397
NCI-H345 GDSC1; GDSC2 4.318 5.3786 2.9576 0.4344
NCI-H524 GDSC1; GDSC2 4.3396 7.7335 1.8959 4.8468
DMS 273 GDSC1; GDSC2 4.3654 12.0079 -0.1851 14.0902
NCI-H1650 GDSC1; GDSC2 4.4156 6.6502 2.4568 2.247
NCI-H2444 GDSC1; GDSC2 4.4247 6.3314 2.6065 1.6154
NCI-H2795 GDSC1; GDSC2 4.4327 11.1469 0.2922 11.9333
UMC-11 GDSC1; GDSC2 4.4415 6.5119 2.5351 1.8866
NCI-H2342 GDSC1; GDSC2 4.4765 7.4066 2.143 3.5241
NCI-H810 GDSC1; GDSC2 4.4767 8.629 1.5582 6.1603
VMRC-LCD GDSC1; GDSC2 4.4855 6.3412 2.6362 1.4293
COR-L23 GDSC1; GDSC2 4.4868 9.0607 1.3558 7.0665
SBC-1 GDSC1; GDSC2 4.5071 6.5949 2.5358 1.8059
NCI-H661 GDSC1; GDSC2 4.5147 7.0377 2.3389 2.6186
NCI-H1781 GDSC1; GDSC2 4.5177 7.7792 1.9937 4.1261
NCI-H1048 GDSC1; GDSC2 4.5274 6.8795 2.419 2.2631
NCI-H522 GDSC1; GDSC2 4.5378 8.7086 1.5622 6.0407
NCI-H513 GDSC1; GDSC2 4.5651 7.9113 1.9622 4.1948
SBC-3 GDSC1; GDSC2 4.5665 7.038 2.3702 2.4186
NCI-H226 GDSC1; GDSC2 4.5674 10.2697 0.8234 9.3366
COLO 668 GDSC1; GDSC2 4.5692 6.9671 2.404 2.2734
EPLC-272H GDSC1; GDSC2 4.5796 10.9463 0.5004 10.7492
Ms-1 GDSC1; GDSC2 4.5933 6.7675 2.5078 1.8192
LC-2/ad GDSC1; GDSC2 4.64 7.8503 2.0393 3.7441
SK-MES-1 GDSC1; GDSC2 4.643 8.2778 1.8395 4.6242
NCI-H1975 GDSC1; GDSC2 4.6528 8.8791 1.559 5.8685
NCI-H1304 GDSC1 4.6595 9.691 1.1715 12.2039
NCI-H847 GDSC1; GDSC2 4.6866 6.1709 2.8103 0.6334
EBC-1 GDSC1; GDSC2 4.6955 7.3294 2.3141 2.4909
NCI-H1793 GDSC1; GDSC2 4.6979 6.7024 2.5939 1.3724
PC-14 GDSC1; GDSC2 4.7107 7.6017 2.1989 2.9569
NCI-H1573 GDSC1; GDSC2 4.7117 12.6553 -0.2433 13.6645
COR-L95 GDSC1 4.7667 7.5798 2.2425 4.476
DMS 53 GDSC1; GDSC2 4.7694 10.1759 1.0135 8.1328
NCI-H2731 GDSC1; GDSC2 4.7743 9.3213 1.4293 6.2576
NCI-H250 GDSC2 4.777 9.2759 1.4529 6.1473
LOU-NH91 GDSC1; GDSC2 4.8065 7.6957 2.2134 2.7726
HOP-92 GDSC1; GDSC2 4.812 8.6392 1.7789 4.6411
Calu-6 GDSC1; GDSC2 4.8544 9.5213 1.3876 6.3171
NCI-H1651 GDSC1; GDSC2 4.8568 10.1719 1.0764 7.705
NCI-H838 GDSC1; GDSC2 4.862 7.2376 2.4497 1.7547
NCI-H596 GDSC1; GDSC2 4.8628 8.5183 1.8681 4.1762
COR-L279 GDSC1; GDSC2 4.875 6.5889 2.7297 0.7515
COR-L88 GDSC1; GDSC2 4.8867 7.0257 2.5542 1.3384
NCI-H2085 GDSC1; GDSC2 4.8933 7.8241 2.2064 2.6944
NCI-H2373 GDSC1; GDSC2 4.9055 7.4975 2.3594 2.0605
NCI-H1792 GDSC1; GDSC2 4.9226 8.5223 1.9039 3.9377
NCI-H1355 GDSC1; GDSC2 4.9309 10.9645 0.7443 9.0541
NCI-H2141 GDSC1; GDSC2 4.9411 7.0385 2.5765 1.2096
NCI-H835 GDSC1; GDSC2 4.9451 7.6089 2.3323 2.1241
NCI-H23 GDSC1; GDSC2 4.9697 10.6497 0.9238 8.1966
NCI-H1623 GDSC1; GDSC2 4.9894 7.4221 2.4381 1.669
NCI-H209 GDSC1; GDSC2 5.0241 7.5393 2.4059 1.7559
NCI-H2081 GDSC1; GDSC2 5.0285 7.4207 2.4593 1.5522
NCI-H2810 GDSC1; GDSC2 5.0644 10.7881 0.9223 8.048
COR-L311 GDSC2 5.0683 6.8419 2.7173 0.6609
SW1271 GDSC1; GDSC2 5.0831 7.193 2.5826 1.071
NCI-H2110 GDSC1; GDSC2 5.091 9.6724 1.4723 5.5803
CPC-N GDSC1; GDSC2 5.0913 6.9548 2.683 0.747
NCI-H187 GDSC1 5.1735 6.2191 2.9872 0.1203
Lu-99A GDSC1; GDSC2 5.179 9.4359 1.6392 4.7268
NCI-H1915 GDSC1; GDSC2 5.1863 6.9882 2.7123 0.6048
NCI-H1876 GDSC1; GDSC2 5.1892 6.9099 2.7438 0.5195
NCI-H841 GDSC1; GDSC2 5.2072 11.5607 0.6482 9.0125
NCI-H2722 GDSC1; GDSC2 5.2117 7.5456 2.4996 1.2469
NCI-H322M GDSC1; GDSC2 5.2191 8.36 2.1531 2.5306
NCI-H2087 GDSC1; GDSC2 5.2196 7.6968 2.4403 1.446
EKVX GDSC1; GDSC2 5.2347 7.7843 2.4111 1.5365
NCI-H2135 GDSC1; GDSC2 5.2419 6.9188 2.7627 0.4464
NCI-H1755 GDSC1; GDSC2 5.251 10.4995 1.1854 6.5988
NCI-H2228 GDSC1; GDSC2 5.259 8.9336 1.9189 3.4358
NCI-H1694 GDSC1; GDSC2 5.2613 6.8883 2.7821 0.3921
ABC-1 GDSC1; GDSC2 5.2675 7.9842 2.343 1.753
IA-LM GDSC1; GDSC2 5.2778 6.6158 2.8877 0.181
NCI-H1648 GDSC1; GDSC2 5.2805 7.8744 2.3964 1.5478
NCI-H1105 GDSC1; GDSC2 5.287 6.9837 2.757 0.4391
NCI-H2803 GDSC1; GDSC2 5.2998 6.9693 2.7676 0.4085
NCI-H146 GDSC1; GDSC2 5.3014 7.0532 2.7367 0.4812
NCI-H1092 GDSC1; GDSC2 5.3318 7.0608 2.7465 0.4435
NCI-H446 GDSC1; GDSC2 5.3352 7.2429 2.6784 0.6132
EMC-BAC-1 GDSC1; GDSC2 5.3381 8.7173 2.0615 2.7621
NCI-H82 GDSC1; GDSC2 5.3538 7.0239 2.7693 0.3819
NCI-H2591 GDSC1; GDSC2 5.3596 10.4263 1.2904 5.9809
IST-SL1 GDSC1; GDSC2 5.3613 7.1638 2.7199 0.4937
NCI-H1993 GDSC1; GDSC2 5.3734 7.5981 2.5555 0.9438
NCI-H1666 GDSC1; GDSC2 5.3909 8.5391 2.1689 2.2846
NCI-H2461 GDSC1; GDSC2 5.3966 11.0683 1.0113 7.1367
NCI-H720 GDSC1; GDSC2 5.4058 7.1241 2.7531 0.3961
NCI-H1437 GDSC1; GDSC2 5.4076 7.9652 2.4219 1.3503
NCI-H2347 GDSC1; GDSC2 5.4169 8.1118 2.3654 1.5372
SK-LU-1 GDSC1; GDSC2 5.4195 7.4419 2.638 0.6753
RERF-LC-Sq1 GDSC1; GDSC2 5.4201 11.5927 0.7773 8.1127
NCI-H2066 GDSC1; GDSC2 5.4684 7.2394 2.7356 0.4089
Lu-65 GDSC1; GDSC2 5.4766 8.2487 2.3379 1.5818
Lu-135 GDSC1; GDSC2 5.4961 7.1046 2.796 0.2757
NCI-H2170 GDSC1; GDSC2 5.4966 10.8046 1.2005 6.1716
NCI-H2804 GDSC1; GDSC2 5.5004 7.6624 2.5876 0.768
NCI-H1581 GDSC1; GDSC2; CTRP2 5.5189 10.6482 3.2911 11.8217
IST-SL2 GDSC1; GDSC2 5.5196 7.8462 2.5235 0.9422
NCI-H1436 GDSC1; GDSC2 5.5336 7.0994 2.8122 0.2355
NCI-H1869 GDSC1; GDSC2 5.5357 11.5143 0.8912 7.445
COR-L32 GDSC1; GDSC2 5.539 7.6002 2.6285 0.635
NCI-H1435 GDSC1; GDSC2 5.5554 6.9794 2.8625 0.153
COR-L321 GDSC1; GDSC2 5.5611 7.2123 2.7822 0.2803
DMS 114 GDSC1; GDSC2 5.5794 11.7847 0.7917 7.8057
LB647-SCLC GDSC1; GDSC2 5.6656 7.3016 2.79 0.2356
HOP-62 GDSC1; GDSC2 5.7131 7.4809 2.7439 0.3024
NCI-H2869 GDSC1; GDSC2 5.7354 10.6475 1.4216 4.906
Lu-165 GDSC1; GDSC2 5.8434 7.1165 2.9166 0.0558
NCI-H2227 GDSC1; GDSC2 5.8457 7.7134 2.7112 0.3204
NCI-H1693 GDSC2 5.8689 7.8958 2.6538 0.4256
SW1573 GDSC1; GDSC2 5.9111 8.3622 2.4953 0.7862
NCI-H2818 GDSC1; GDSC2 5.9179 13.1938 0.3457 9.1685
NCI-H520 GDSC1; GDSC2 6.0495 13.6582 0.2119 9.5176
KNS-62 GDSC1; GDSC2 6.0627 7.8272 2.7522 0.1959
A-427 GDSC1; GDSC2 6.0991 15.6987 -0.7327 13.153
NCI-H1568 GDSC1; GDSC2 6.202 14.0718 0.1161 9.6757
Lu-134-A GDSC1; GDSC2 6.2722 8.5962 2.5568 0.4748
DMS 79 GDSC1; GDSC2; CTRP2 6.7075 16.4941 1.3613 16.6394
BEN GDSC1; GDSC2; CTRP2 6.9539 8.014 5.6747 0.426
RERF-LC-Ad1 CTRP2 6.9784 18.417 0.6182 19.4832
NCI-H1838 GDSC1; GDSC2; CTRP2 7.3082 9.5882 5.182 1.6798
NCI-H211 GDSC1; GDSC2; CTRP2 7.3234 14.7496 2.7063 10.8878
NCI-H1734 GDSC2; CTRP2 7.466 11.7306 4.281 4.7574
NCI-H1155 GDSC1; GDSC2; CTRP2 7.5355 12.7298 3.848 6.2917
MOR/CPR CTRP2 7.6331 8.7736 5.6726 0.1584
NCI-H196 GDSC1; GDSC2; CTRP2 7.7092 9.8026 5.3044 0.9559
SBC-5 GDSC1; GDSC2; CTRP2 7.7375 8.7463 5.7204 0.0709
LC-1/sq GDSC1; GDSC2 7.8827 16.7556 -0.0821 8.1483
NCI-H441 GDSC1; GDSC2 8.0106 19.1331 -1.1014 11.6334
Lu-99 CTRP2 8.0257 9.2531 5.6492 0.1058
LCLC-103H GDSC1; GDSC2; CTRP2 8.0515 9.2228 5.6687 0.0763
NCI-H292 GDSC1; GDSC2; CTRP2 8.0644 9.5693 5.5519 0.2184
NCI-H2291 GDSC1; GDSC2; CTRP2 8.0691 10.3606 5.2492 0.8735
NCI-H650 GDSC1; GDSC2; CTRP2 8.1473 9.6023 5.5717 0.1693
NCI-H460 GDSC1; GDSC2; CTRP2 8.1677 9.7161 5.5388 0.2112
HCC366 GDSC1; GDSC2; CTRP2 8.1809 13.8386 3.7516 5.8081
NCI-H526 GDSC1; GDSC2; CTRP2 8.2101 9.4578 5.6446 0.0774
CAL-12T GDSC1; GDSC2; CTRP2 8.288 10.26 5.3862 0.4422
HCC1171 CTRP2 8.2929 17.1297 2.2455 11.7514
NCI-H358 GDSC1; GDSC2; CTRP2 8.3528 10.3452 5.381 0.4276
HCC2108 CTRP2 8.3618 14.1557 3.7192 6.0768
NCI-H2405 GDSC1; GDSC2; CTRP2 8.5101 12.912 4.3826 3.2055
NCI-H69 GDSC1; GDSC2; CTRP2 8.5613 10.8684 5.2699 0.5711
HCC15 GDSC1; GDSC2; CTRP2 8.6069 11.8766 4.8856 1.5283
COLO 699 CTRP2 8.6243 13.7389 4.0753 4.4158
HCC44 GDSC1; GDSC2; CTRP2 8.6271 18.4502 1.8399 12.0061
NCI-H2009 GDSC1; GDSC2; CTRP2 8.72 10.7723 5.3707 0.3235
NCI-H1299 GDSC1; GDSC2; CTRP2 8.7829 16.4235 2.9213 8.0463
HCC1588 CTRP2 8.8913 20.0198 1.2637 14.242
NCI-H2106 CTRP2 8.9242 10.6936 5.475 0.1481
Calu-3 GDSC1; GDSC2; CTRP2 9.2744 20.8603 1.125 13.4173
HCC2279 CTRP2 9.5109 18.2059 2.5529 8.9328
COR-L105 GDSC1; GDSC2 9.5251 21.0033 -1.0405 9.5348
NCI-H727 GDSC1; GDSC2; CTRP2 9.5672 17.3067 3.0082 6.806
HCC1833 CTRP2 9.6267 19.8737 1.8391 11.2688
HARA [Human squamous cell lung carcinoma] GDSC1; GDSC2; CTRP2 9.7796 17.5871 3.009 6.5677
RERF-LC-A1 CTRP2 10.2491 17.344 3.3946 5.1186
HCC78 GDSC1; GDSC2; CTRP2 10.4764 23.6911 0.5853 13.4573
NCI-H2030 GDSC1; GDSC2; CTRP2 10.4965 20.5225 2.0937 8.7967
SHP-77 GDSC1; GDSC2; CTRP2 11.3333 22.4756 1.7064 9.091
HCC827 GDSC1; GDSC2; CTRP2 11.5227 21.7409 2.155 7.5124
⏷ Show the Full List of 197 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1; GDSC2 4.4571 6.987 2.3269 2.7476
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
T.T GDSC1; GDSC2 3.2597 6.3578 1.7519 7.5912
OE21 GDSC1; GDSC2 3.5688 5.5662 2.3983 3.8764
KYSE-510 GDSC1; GDSC2 4.2988 8.831 1.333 7.5001
TE-11 GDSC1; GDSC2 4.3052 6.4136 2.4984 2.2147
TE-4 GDSC1; GDSC2 4.3136 7.5423 1.9701 4.5514
KYSE-410 GDSC1; GDSC2 4.6347 8.1435 1.8978 4.3774
TE-5 GDSC1; GDSC2 4.8475 6.5885 2.7169 0.8118
OE33 GDSC1; GDSC2 4.8783 7.917 2.1554 2.9252
KYSE-450 GDSC1; GDSC2 4.9362 8.8839 1.7436 4.6158
KYSE-270 GDSC1; GDSC2 4.9561 9.5417 1.4458 5.8996
TE-1 GDSC1; GDSC2 5.1862 8.6591 2.0003 3.1881
EC-GI-10 GDSC1; GDSC2 5.1987 7.6299 2.4579 1.4022
TE-6 GDSC1; GDSC2 5.2368 9.8397 1.4871 5.3039
KYSE-150 GDSC1; GDSC2 5.2408 6.5491 2.8974 0.1751
KYSE-70 GDSC1; GDSC2 5.3384 7.6084 2.535 1.0324
OE19 GDSC1; GDSC2 5.9353 12.2208 0.8162 7.1781
KYSE-520 GDSC1; GDSC2 6.0338 11.9643 0.9973 6.2836
TE-15 GDSC1; GDSC2 6.1868 8.4083 2.5918 0.4348
TE-8 GDSC1; GDSC2 6.3684 13.4308 0.5246 7.7743
TE-9 GDSC1; GDSC2; CTRP2 7.9825 9.4665 5.5574 0.2327
COLO 680N GDSC1; GDSC2; CTRP2 8.3228 9.6299 5.6256 0.0798
TE-10 GDSC1; GDSC2; CTRP2 8.5263 10.5259 5.3843 0.3602
KYSE-140 GDSC1; GDSC2; CTRP2 9.4464 18.2895 2.4719 8.7803
KYSE-180 GDSC1; GDSC2; CTRP2 13.4388 25.4108 1.608 7.3347
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Caov-3 GDSC2 1.8185 3.2331 -0.4651 0.3724
TOV-21G GDSC1; GDSC2 3.7463 6.419 2.1113 4.8873
JHOS-4 GDSC1; GDSC2 3.753 6.1772 2.2357 4.2907
OC 314 GDSC1; GDSC2 3.7622 8.8652 0.9081 10.4902
OV56 GDSC1; GDSC2 4.1377 6.2076 2.4891 2.4895
TYK-nu GDSC1; GDSC2 4.2781 6.8581 2.2731 3.2405
A2780 GDSC1; GDSC2 4.2886 9.0137 1.2359 7.9651
OAW42 GDSC1; GDSC2 4.3877 12.3696 -0.3473 14.7127
RMG-I GDSC1; GDSC2 4.3932 8.0212 1.7941 5.2231
FU-OV-1 GDSC1; GDSC2 4.4 8.3278 1.6506 5.8667
TOV-112D GDSC1; GDSC2 4.5162 8.2446 1.7708 5.1301
OVCAR-5 GDSC1; GDSC2 4.525 6.5936 2.5466 1.7416
OVK18 GDSC1; GDSC2 4.6831 8.2609 1.8738 4.4116
EFO-27 GDSC1; GDSC2 4.7029 6.4863 2.6885 1.0236
OVCAR-3 GDSC1; GDSC2 4.7573 7.3074 2.3602 2.2264
OVCAR-4 GDSC1; GDSC2 5.0631 8.7676 1.8771 3.8628
OV-90 GDSC1; GDSC2 5.1796 7.392 2.5474 1.1119
SK-OV-3 GDSC1; GDSC2 5.1822 10.3333 1.219 6.5557
ES-2 GDSC1; GDSC2 5.2186 6.8252 2.7883 0.3966
OVKATE GDSC1; GDSC2 5.278 10.3324 1.282 6.1366
Caov-4 GDSC1; GDSC2 5.3027 7.8215 2.4298 1.4107
EFO-21 GDSC1; GDSC2 5.4735 7.1879 2.7567 0.3612
JHOS-2 GDSC1; GDSC2 5.6621 7.5782 2.6882 0.4337
OAW28 GDSC1; GDSC2 6.1269 10.4654 1.7281 3.2112
IGROV-1 GDSC1; GDSC2 6.5684 8.7975 2.5983 0.3051
OVCAR-8 GDSC1; GDSC2 7.0275 13.8973 0.71 6.1742
OVISE GDSC1; GDSC2; CTRP2 7.4824 8.8614 5.5784 0.3777
ES2 CTRP2 7.558 8.7055 5.6682 0.1867
OVSAHO CTRP2 7.7266 10.9551 4.809 2.7046
SNU-8 CTRP2 7.9117 9.2844 5.5959 0.2044
DOV13 GDSC1; GDSC2; CTRP2 8.1701 9.7308 5.5345 0.2171
ONCO-DG-1 CTRP2 8.2812 9.7687 5.5628 0.1627
SNU-119 CTRP2 8.8766 16.5778 2.9097 8.4641
Kuramochi GDSC1; GDSC2; CTRP2 10.4722 20.8466 1.9276 9.3573
OVTOKO GDSC1; GDSC2; CTRP2 12.6394 24.8307 1.4118 8.6321
JHOC-5 CTRP2 13.4245 24.8698 1.8377 7.0661
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuP-T3 GDSC1; GDSC2 4.1884 6.5781 2.347 3.0461
Capan-2 GDSC2 4.3635 7.9623 1.8019 5.236
KP-1N GDSC1; GDSC2 4.4265 6.9699 2.3157 2.8383
SU.86.86 GDSC1; GDSC2 4.4602 7.8676 1.9134 4.5745
HuP-T4 GDSC1; GDSC2 4.5502 8.1341 1.8465 4.7354
DAN-G GDSC1; GDSC2 4.5596 7.6924 2.062 3.7605
PL4 GDSC1; GDSC2 4.8547 7.7127 2.2341 2.6267
MZ-PC-1 GDSC1; GDSC2 4.9515 7.6444 2.3201 2.1652
HPAC GDSC1; GDSC2 4.9904 8.7066 1.8605 4.032
Panc 10.05 GDSC1; GDSC2 5.0192 8.9574 1.7618 4.4187
PaTu 8902 GDSC1; GDSC2 5.0314 9.2679 1.6242 5.0011
MIA PaCa-2 GDSC1; GDSC2 5.0902 10.7977 0.9353 7.9485
Hs 766T GDSC1; GDSC2 5.1188 8.2059 2.165 2.5964
Capan-1 GDSC1; GDSC2 5.2752 7.1424 2.6913 0.612
Panc 08.13 GDSC1; GDSC2 5.3206 10.3132 1.3185 5.9153
PSN1 GDSC1; GDSC2 5.5506 8.4496 2.2909 1.6827
YAPC GDSC1; GDSC2 5.5621 12.9748 0.2108 10.2908
KP-2 GDSC1; GDSC2 5.7475 11.0507 1.2433 5.6392
Panc 02.03 GDSC1; GDSC2 5.8574 13.7877 0.0215 10.5928
SW1990 GDSC1; GDSC2 5.891 12.6173 0.6013 8.1442
Panc 03.27 GDSC1; GDSC2 6.0133 7.6914 2.7814 0.167
AsPC-1 GDSC2 6.3336 8.9871 2.436 0.7213
Panc 04.03 GDSC1; GDSC2 6.4336 13.1094 0.7142 6.9126
SNU-213 CTRP2 6.9869 9.4548 5.0462 2.6872
PaTu 8988t GDSC1; GDSC2 7.3861 17.7479 -0.8505 11.6207
QGP-1 GDSC1; GDSC2; CTRP2 7.7226 9.0376 5.6117 0.2198
KP-4 GDSC1; GDSC2; CTRP2 7.8469 8.9054 5.7048 0.0705
KP-3 GDSC1; GDSC2; CTRP2 7.967 12.7267 4.1374 4.6616
SUIT-2 GDSC1; GDSC2; CTRP2 8.1457 10.1271 5.3765 0.5229
CFPAC-1 GDSC1; GDSC2; CTRP2 8.3999 16.7003 2.5289 9.9461
HPAF-II GDSC1; GDSC2; CTRP2 9.7959 16.9182 3.3244 5.4886
BxPC-3 GDSC1; GDSC2; CTRP2 10.186 20.9628 1.6899 10.4544
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H GDSC1; GDSC2 4.0471 9.4318 0.8483 10.1964
NCI-H2452 GDSC1; GDSC2 4.0748 8.3242 1.4172 7.5197
IST-Mes1 GDSC1; GDSC2 4.5669 8.9282 1.4763 6.3827
MPP 89 GDSC1; GDSC2 5.2782 7.078 2.7174 0.5414
NCI-H2052 GDSC2 5.4262 7.2547 2.7126 0.4806
ACC-MESO-1 CTRP2 7.9201 9.4019 5.5564 0.2701
NCI-H28 GDSC1; GDSC2; CTRP2 10.5486 19.8889 2.4185 7.6896
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H660 GDSC2 1.7593 3.0811 -0.4329 0.3158
LNCaP clone FGC GDSC1; GDSC2 2.6898 7.6713 0.6003 14.3073
VCaP GDSC1; GDSC2 5.1617 11.2709 0.7565 8.6161
PC-3 GDSC1; GDSC2 5.1628 8.0997 2.2367 2.2629
DU145 GDSC1; GDSC2 5.3674 7.7482 2.4918 1.1498
22Rv1 GDSC1; GDSC2; CTRP2 8.5919 14.4055 3.7481 5.33
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1; GDSC2 4.0378 7.4224 1.8334 5.6508
YD-15 CTRP2 7.9375 8.8081 5.7681 0.0221
Cancer Drug Sensitivity Data Curated from 57 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-MEL-28 GDSC1; GDSC2 3.5401 5.7422 2.2884 4.4521
RVH-421 GDSC1; GDSC2 3.9566 6.6586 2.1484 4.3317
MMAc-SF GDSC1; GDSC2 3.9581 6.5173 2.2184 4.005
SK-MEL-3 GDSC1; GDSC2 3.9918 7.9323 1.5484 7.0634
WM115 GDSC1; GDSC2 4.0009 7.0787 1.975 5.0584
A2058 GDSC2 4.0732 5.9726 2.5582 2.2784
G-361 GDSC1; GDSC2 4.0903 8.0508 1.5633 6.8121
IPC-298 GDSC1; GDSC2 4.1283 6.4385 2.3736 3.0184
G-mel GDSC1; GDSC2 4.162 7.8578 1.7103 6.001
GAK GDSC1; GDSC2 4.1798 6.3384 2.4547 2.5802
CP66-MEL GDSC1; GDSC2 4.2036 6.1729 2.5471 2.1427
A-431 GDSC1; GDSC2 4.2264 8.3195 1.531 6.7168
MZ-MEL-7 GDSC1; GDSC2 4.2269 6.3693 2.4702 2.4445
MZ-MEL-2 GDSC1; GDSC2 4.2331 6.7548 2.2925 3.2217
SK-MEL-2 GDSC1; GDSC2 4.2712 5.4228 2.9175 0.5971
Hs 938.T GDSC1; GDSC2 4.3467 6.1553 2.6407 1.5675
DJM-1 GDSC1; GDSC2 4.3656 8.1732 1.7014 5.692
SK-MEL-30 GDSC1; GDSC2 4.3826 6.2704 2.6097 1.6515
Hs 940.T GDSC1; GDSC2 4.3911 6.5856 2.4716 2.2157
M14 GDSC1; GDSC2 4.4063 7.8815 1.8703 4.8552
COLO 800 GDSC1; GDSC2 4.4083 6.4979 2.522 1.982
HT-144 GDSC1; GDSC2 4.4312 8.0437 1.8093 5.0918
LB2518-MEL GDSC1; GDSC2 4.4491 6.3274 2.6221 1.5253
IGR-1 GDSC1; GDSC2 4.4706 6.5377 2.5404 1.8299
UACC-257 GDSC1; GDSC2 4.4724 9.3177 1.2204 7.7092
LOX-IMVI GDSC1; GDSC2 4.5134 7.2507 2.2395 3.0487
VMRC-MELG GDSC1; GDSC2 4.5586 6.3784 2.6596 1.2634
Mel JuSo GDSC1; GDSC2 4.6768 12.0272 0.0404 12.5513
CP50-MEL-B GDSC1; GDSC2 4.6916 12.0215 0.0541 12.466
HMV-II GDSC1; GDSC2 4.7006 10.7203 0.6994 9.6524
WM793 GDSC1; GDSC2 4.7235 6.5011 2.6926 0.9914
MeWo GDSC1; GDSC2 4.7651 7.9603 2.0667 3.4506
A-388 GDSC1; GDSC2 4.8053 7.0144 2.5162 1.5584
451Lu GDSC1; GDSC2 4.8636 6.8074 2.6345 1.0741
WM1552C GDSC1; GDSC2 4.871 6.5823 2.7305 0.7517
SK-MEL-5 GDSC1; GDSC2 4.8724 6.8036 2.6405 1.0461
A101D GDSC1; GDSC2 4.941 11.0148 0.727 9.1131
UACC-62 GDSC1; GDSC2 4.963 6.3778 2.8509 0.3648
IST-MEL1 GDSC1; GDSC2 4.9975 9.6711 1.4117 5.9878
COLO 783 GDSC1; GDSC2 5.0088 6.7488 2.7273 0.6692
COLO 792 GDSC1; GDSC2 5.0758 10.0243 1.2955 6.3816
LB373-MEL-D GDSC1; GDSC2 5.0765 6.3698 2.8992 0.2193
CHL-1 GDSC1; GDSC2 5.1012 9.5788 1.5229 5.3434
A-375 GDSC1; GDSC2 5.1689 9.9364 1.3982 5.79
WT2-iPS GDSC1; GDSC2 5.3536 10.562 1.2227 6.2833
WM278 GDSC1; GDSC2 5.3756 8.0492 2.3709 1.5538
IGR-37 GDSC1; GDSC2 5.5028 12.7231 0.2913 10.051
COLO 679 GDSC1; GDSC2 5.5477 7.5385 2.6558 0.561
SH-4 GDSC1; GDSC2 5.8293 7.9858 2.6042 0.5528
SK-MEL-31 GDSC1; GDSC2 5.8722 7.3953 2.8328 0.1301
WM35 GDSC1; GDSC2 6.0226 12.4125 0.7819 7.1979
COLO 829 GDSC1; GDSC2 6.3001 12.9592 0.7013 7.1462
SK-MEL-24 GDSC1; GDSC2 6.4332 15.6521 -0.4828 11.675
SK-MEL-1 GDSC1; GDSC2; CTRP2 7.0139 8.5154 5.4927 0.9252
Mel Ho GDSC1; GDSC2; CTRP2 7.9857 9.6143 5.5041 0.3256
RPMI-7951 GDSC1; GDSC2; CTRP2 9.1451 20.1234 1.3915 12.7541
EquiPSC Line K2 GDSC1; GDSC2 5.1949 7.5882 2.4735 1.3509
⏷ Show the Full List of 57 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1; GDSC2 4.5309 9.2921 1.2745 7.361
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE 441.T GDSC2 1.6331 3.1237 -0.5001 0.5871
STS-0421 GDSC1; GDSC2 4.0729 6.8382 2.1435 4.1548
EW-8 GDSC1; GDSC2 4.312 8.0199 1.7381 5.6141
SK-LMS-1 GDSC1; GDSC2 4.4279 8.1547 1.7536 5.3506
KYM-1 GDSC1; GDSC2 4.4325 7.104 2.2569 3.0865
RKN GDSC1; GDSC2 4.4781 6.6681 2.4859 2.0457
G-402 GDSC1; GDSC2 4.7738 8.016 2.0463 3.5267
Hs 633.T GDSC1; GDSC2 4.8043 8.1265 2.014 3.6244
Rh18 GDSC1 4.9048 7.5958 2.3154 3.7087
SW872 GDSC1; GDSC2 4.9144 8.2655 2.0175 3.461
Rh30 GDSC1; GDSC2 4.9646 7.1903 2.5244 1.3745
MFH-ino GDSC1; GDSC2 5.0358 8.8356 1.8288 4.1064
SW982 GDSC1; GDSC2 5.1342 6.623 2.8293 0.34
A-204 GDSC1; GDSC2 5.3177 11.7292 0.6428 8.8556
G-401 GDSC1; GDSC2 5.3515 9.6001 1.6698 4.3626
SW684 GDSC1; GDSC2 5.362 6.5966 2.925 0.1106
HT-1080 GDSC1; GDSC2 5.3755 6.866 2.8355 0.2415
SK-UT-1 GDSC1; GDSC2 5.3938 10.4945 1.2803 5.9752
MES-SA GDSC1; GDSC2 5.6805 12.3615 0.5844 8.5335
GCT GDSC1; GDSC2 5.755 7.4146 2.7835 0.2224
VA-ES-BJ GDSC1; GDSC2 5.9572 7.6241 2.7844 0.1743
RD GDSC1; GDSC2 5.9815 8.3215 2.5408 0.634
Rh41 GDSC1; GDSC2; CTRP2 8.4311 10.135 5.4892 0.2181
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 35 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ECC12 GDSC2 1.2211 2.3369 -0.3744 0.4405
HSC-39 GDSC1; GDSC2 3.3642 5.3156 2.3601 4.476
MKN28 GDSC1; GDSC2 3.4828 9.1922 0.5198 12.8491
Fu97 GDSC1; GDSC2 3.7093 14.1588 -1.7772 21.418
TMK-1 GDSC1; GDSC2 3.9582 6.0578 2.4411 2.9821
SNU-16 GDSC1; GDSC2 4.0022 6.7417 2.1405 4.2892
HGC-27 GDSC2 4.2895 9.3224 1.0849 8.6559
SCH GDSC1; GDSC2 4.3157 5.8438 2.7612 1.1243
SNU-1 GDSC1; GDSC2 4.3403 6.3335 2.5564 1.9236
IM95 GDSC1; GDSC2 4.5397 6.9462 2.396 2.3443
KATO III GDSC1; GDSC2 4.6825 7.753 2.1115 3.3699
RF-48 GDSC1; GDSC2 4.89 6.9593 2.584 1.2283
GCIY GDSC2 4.8984 7.6611 2.2826 2.3761
OCUM-1 GDSC1; GDSC2 4.9005 8.2851 2 3.5543
MKN7 GDSC1; GDSC2 5.1088 8.8169 1.8822 3.7806
ECC10 GDSC1; GDSC2 5.2203 7.1199 2.6759 0.6864
RERF-GC-1B GDSC1; GDSC2 5.3093 11.758 0.6232 8.9538
NUGC-3 GDSC1; GDSC2 5.5582 7.5245 2.6656 0.5319
Hs 746.T GDSC1; GDSC2 5.6258 10.617 1.3688 5.2728
SK-GT-2 GDSC1; GDSC2 5.7922 8.3487 2.4478 0.9898
TGBC11TKB GDSC1; GDSC2 5.9303 7.6728 2.7576 0.2185
SNU-620 CTRP2 7.4204 8.8187 5.5677 0.4617
MKN45 GDSC1; GDSC2; CTRP2 7.47 8.478 5.7162 0.1254
GSS CTRP2 7.5658 14.2928 3.1091 9.6015
SNU-5 GDSC1; GDSC2; CTRP2 7.6437 9.0873 5.5608 0.3449
NUGC-4 GDSC1; GDSC2; CTRP2 7.6843 13.7056 3.4794 7.4711
SNU-668 CTRP2 7.7575 10.0541 5.2231 1.2356
AGS GDSC1; GDSC2; CTRP2 8.087 16.9058 2.2075 11.5236
MKN1 GDSC1; GDSC2; CTRP2 8.2106 16.6322 2.4292 10.5647
NCI-N87 GDSC1; GDSC2; CTRP2 10.2421 21.9051 1.2804 11.6702
23132/87 GDSC1; GDSC2; CTRP2 10.5829 21.1381 1.8613 9.441
SNU-719 CTRP2 13.2364 26.1867 1.1477 9.2579
KE-39 CTRP2 13.4098 24.9484 1.7953 7.2037
SNG-M GDSC1; GDSC2 4.2821 6.9344 2.2395 3.3844
SNU-1077 CTRP2 12.7132 24.3962 1.6498 8.2956
⏷ Show the Full List of 35 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ML-1 [Human leukemia] GDSC2 2.5452 4.1458 -0.5159 0.2188
CAL-62 GDSC1; GDSC2 3.9153 9.8632 0.5317 11.8906
FTC-133 GDSC1; GDSC2 3.9457 6.667 2.1364 4.4061
IHH-4 GDSC1; GDSC2 4.0348 11.2604 -0.0699 14.2695
KMH-2 GDSC1; GDSC2 4.1705 6.4636 2.3895 2.883
K5 GDSC1; GDSC2 4.5223 7.0499 2.3379 2.6126
B-CPAP GDSC1; GDSC2 4.7139 7.3982 2.2938 2.5528
WRO GDSC1; GDSC2 4.8483 8.0729 2.0658 3.3425
HTC-C3 GDSC1; GDSC2 4.8588 10.5002 0.9189 8.4036
ASH-3 GDSC1; GDSC2 5.4001 7.6159 2.5607 0.9098
TT2609-C02 GDSC1; GDSC2 5.6601 7.5861 2.6844 0.4428
8505C GDSC1; GDSC2; CTRP2 7.9959 12.8306 4.1072 4.7371
8305C GDSC1; GDSC2; CTRP2 8.1178 9.6257 5.5522 0.204
CGTH-W-1 GDSC2; CTRP2 8.2715 9.4659 5.6631 0.056
BHT-101 GDSC1; GDSC2; CTRP2 8.3851 9.6979 5.6244 0.0735
TT GDSC1; GDSC2; CTRP2 9.422 17.9995 2.5928 8.3975
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 48 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BICR 31 GDSC2 3.0218 4.9664 -0.6279 0.2875
KOSC-2 GDSC1; GDSC2 3.4328 8.2319 0.9587 10.9466
PCI-38 GDSC1 3.457 7.7645 1.2121 15.773
HSC-4 GDSC1; GDSC2 3.7504 6.0795 2.2819 4.0794
CAL-33 GDSC1; GDSC2 3.8117 6.2009 2.2674 4.0355
BB30-HNC GDSC1; GDSC2 3.8825 6.7183 2.0653 4.8503
PCI-15A GDSC1; GDSC2 4.1103 6.1324 2.5068 2.4513
OSC-19 GDSC1; GDSC2 4.1803 8.0512 1.6289 6.3458
PE/CA-PJ15 GDSC1; GDSC2 4.1891 6.936 2.1765 3.8135
SAS GDSC1; GDSC2 4.3792 9.6194 1.005 8.8565
SCC-25 GDSC1; GDSC2 4.408 7.1817 2.2047 3.3517
FaDu GDSC1; GDSC2 4.4196 10.9263 0.3913 11.526
CAL-27 GDSC1; GDSC2 4.449 8.2561 1.7192 5.4725
BICR 22 GDSC1; GDSC2 4.5 10.1449 0.8355 9.4041
HO-1-N-1 GDSC1; GDSC2 4.5042 6.703 2.4855 2.0155
SKN-3 GDSC1; GDSC2 4.5816 7.9191 1.9693 4.1387
SAT [Human HNSCC] GDSC1; GDSC2 4.5845 11.0453 0.4552 10.9383
PCI-30 GDSC1; GDSC2 4.6515 8.9828 1.5082 6.0997
KON GDSC1; GDSC2 4.6582 6.6628 2.5898 1.4277
OSC-20 GDSC1; GDSC2 4.6998 8.4416 1.7993 4.7178
JHU-029 GDSC1; GDSC2 4.7307 7.1429 2.4185 2.0214
UPCI-SCC-090 GDSC1; GDSC2 4.7613 12.2102 0.0129 12.5105
PCI-06A GDSC1; GDSC2 4.8933 7.2001 2.4828 1.5961
HO-1-u-1 GDSC1; GDSC2 4.9624 11.0886 0.7062 9.1682
DOK GDSC1; GDSC2 4.9736 9.4854 1.4841 5.7036
BICR 78 GDSC1; GDSC2 5.0858 10.3038 1.169 6.9248
JHU-022 GDSC1; GDSC2 5.0908 10.5213 1.0684 7.3613
SCC-4 GDSC1; GDSC2 5.1065 10.9359 0.88 8.1656
NCI-H3118 GDSC1; GDSC2 5.1607 7.4786 2.5022 1.2804
Ca9-22 GDSC1; GDSC2 5.2406 12.7809 0.0804 11.3729
BB49-HNC GDSC1; GDSC2 5.2712 12.7516 0.1163 11.1708
HSC-2 GDSC1; GDSC2 5.4152 8.3782 2.2515 1.9493
LB771-HNC GDSC1; GDSC2 5.4496 12.863 0.1871 10.5745
SCC-9 GDSC1; GDSC2 5.7901 7.3421 2.8217 0.1591
SCC-15 GDSC1; GDSC2 5.8507 7.7088 2.7148 0.3122
JHU-011 GDSC1; GDSC2 5.9237 8.3215 2.5163 0.7242
PCI-04B GDSC1; GDSC2 6.0415 8.0452 2.667 0.3392
BICR 10 GDSC1; GDSC2 6.6042 15.869 -0.4722 11.3731
Detroit 562 GDSC1; GDSC2; CTRP2 7.6153 10.4829 4.9573 2.1393
SNU-46 CTRP2 7.6396 9.6444 5.3358 0.9755
YD-10B CTRP2 7.8203 9.0373 5.6493 0.1466
SNU-1214 CTRP2 8.0108 10.5495 5.1427 1.2894
BHY GDSC1; GDSC2; CTRP2 8.186 9.6089 5.5838 0.1455
SNU-899 CTRP2 8.2041 11.9531 4.6366 2.8236
SNU-1076 CTRP2 8.2491 9.2396 5.7302 0.0225
SNU-1066 CTRP2 8.4819 9.8626 5.6024 0.0856
SNU-1041 CTRP2 8.6606 10.3178 5.5099 0.1542
HSC-3 GDSC1; GDSC2; CTRP2 11.4913 21.868 2.079 7.7787
⏷ Show the Full List of 48 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 17 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW1710 GDSC1; GDSC2 4.354 6.7296 2.3822 2.6502
HT-1197 GDSC1; GDSC2 4.6421 7.9684 1.9852 3.9791
BFTC-905 GDSC1; GDSC2 4.7495 10.9114 0.6411 9.8234
CAL-29 GDSC1; GDSC2 4.8205 9.5415 1.355 6.5169
J82 GDSC1; GDSC2 4.9695 8.0355 2.1554 2.8121
T24 GDSC1; GDSC2 4.9758 8.6445 1.8802 3.9671
SW780 GDSC1; GDSC2 5.1766 6.8165 2.7741 0.4496
UM-UC-3 GDSC1; GDSC2 5.1853 14.885 -0.9898 15.6951
647V GDSC1; GDSC2 5.3371 6.492 2.9519 0.0846
RT-4 GDSC1; GDSC2 5.4349 7.7098 2.5391 0.9518
HT-1376 GDSC1; GDSC2 6.0167 14.5392 -0.2309 11.3506
RT-112 GDSC1; GDSC2 6.5847 14.4893 0.1668 8.912
639V GDSC1; GDSC2; CTRP2 7.3067 8.3925 5.683 0.2311
KU-19-19 GDSC1; GDSC2; CTRP2 7.793 9.0281 5.6424 0.1531
5637 GDSC1; GDSC2; CTRP2 8.2132 17.3281 2.092 11.7406
TCCSUP GDSC1; GDSC2; CTRP2 8.5151 14.082 3.8506 5.0535
VM-CUB-1 CTRP2 9.6762 17.5878 2.9454 7.324
⏷ Show the Full List of 17 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCC-IT GDSC2 1.8391 3.6202 -0.6028 0.8007
JAR GDSC1; GDSC2 2.8626 4.5301 2.3024 5.9455
NT2-D1 GDSC1; GDSC2 2.8694 5.4274 1.8718 7.9407
SW954 GDSC1; GDSC2 3.6197 6.8953 1.777 6.711
DoTc2 4510 GDSC1; GDSC2 4.2151 6.0738 2.5999 1.9008
C-33 A GDSC1; GDSC2 4.2271 7.4416 1.959 4.7437
SW962 GDSC1; GDSC2 4.317 6.9106 2.2737 3.18
OVCA420 GDSC1; GDSC2 4.3267 6.2996 2.5638 1.9096
ME-180 GDSC1; GDSC2 4.3511 10.0386 0.778 9.9361
OV17R GDSC1; GDSC2 4.3904 7.3049 2.135 3.6873
UWB1.289 GDSC1; GDSC2 4.4218 8.0873 1.7819 5.2316
OMC-1 [Human cervical carcinoma] GDSC1; GDSC2 4.4681 7.586 2.0528 3.9374
HEY GDSC1; GDSC2 4.4865 7.3264 2.1871 3.3154
PA-1 GDSC2 4.5135 6.7855 2.4535 2.1364
OVCA433 GDSC1; GDSC2 4.5863 7.3791 2.2252 3.0103
JEG-3 GDSC1; GDSC2 4.6206 6.3026 2.7242 0.9699
HT-3 GDSC1; GDSC2 4.6328 7.8884 2.0169 3.8533
SKN GDSC1; GDSC2 4.6434 6.9077 2.4737 1.899
SW756 GDSC1; GDSC2 4.7001 9.4692 1.3072 6.9276
NEC8 GDSC1; GDSC2 4.8165 9.0035 1.6093 5.3864
SiSo GDSC1; GDSC2 4.8295 9.3607 1.4477 6.0876
KGN GDSC1; GDSC2 4.8632 11.9499 0.2153 11.4686
BPH-1 GDSC1; GDSC2 4.8702 8.0491 2.0901 3.2105
LB831-BLC GDSC1; GDSC2 5.1663 10.6174 1.0731 7.2212
JHOS-3 GDSC1; GDSC2 5.1847 7.5698 2.4761 1.3506
HEC-1 GDSC1; GDSC2 5.243 10.2419 1.302 6.1011
PWR-1E GDSC1; GDSC2 5.2549 7.405 2.578 0.9566
Ca Ski GDSC1; GDSC2 5.2943 10.5957 1.1682 6.6087
OVMIU GDSC1; GDSC2 5.3549 12.2325 0.426 9.7239
SKG-IIIa GDSC1; GDSC2 5.4469 7.2256 2.732 0.4261
C-4-I GDSC1; GDSC2 5.4694 8.1428 2.3786 1.447
ACC-OV7 GDSC1; GDSC2 5.5354 8.6496 2.1981 2.0313
DSH1 GDSC1; GDSC2 5.8251 11.9834 0.8573 7.1632
TC-YIK GDSC1; GDSC2 5.899 7.8593 2.679 0.3637
CAL-39 GDSC1; GDSC2 5.9299 8.0816 2.6096 0.4969
PEO1 GDSC1; GDSC2 6.4585 17.9387 -1.5663 15.5385
SiHa GDSC1; GDSC2 6.5982 14.0767 0.3679 8.0895
HeLa GDSC1; GDSC2 6.8431 14.7461 0.2096 8.3828
MS751 GDSC1; GDSC2 7.7632 18.1552 -0.8009 10.9186
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Fulvestrant (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Omacetaxine mepesuccinate DMPU2WX Moderate Additive myelosuppressive effects by the combination of Fulvestrant and Omacetaxine mepesuccinate. Myeloproliferative neoplasm [2A20] [10]

References

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2 BDDCS applied to over 900 drugs
3 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
4 Estimating the safe starting dose in phase I clinical trials and no observed effect level based on QSAR modeling of the human maximum recommended daily dose
5 Beta3-tubulin is induced by estradiol in human breast carcinoma cells through an estrogen-receptor dependent pathway. Cell Motil Cytoskeleton. 2009 Jul;66(7):378-88.
6 Fulvestrant: pharmacologic profile versus existing endocrine agents for the treatment of breast cancer. Ann Pharmacother. 2006 Sep;40(9):1572-83.
7 Inactivation of the pure antiestrogen fulvestrant and other synthetic estrogen molecules by UDP-glucuronosyltransferase 1A enzymes expressed in breast tissue. Mol Pharmacol. 2006 Mar;69(3):908-20.
8 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
9 Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem. 2006 Aug 1;98(5):1163-84.
10 Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.