Details of the Drug

General Information of Drug (ID: DM1945H)

Drug Name
JTT-251
Indication
Disease Entry ICD 11 Status REF
Pulmonary arterial hypertension BB01.0 Phase 2 [1]
Type-2 diabetes 5A11 Phase 1 [2]
Cross-matching ID
PubChem CID
78210288
UNII
VZ3FG834W3
DrugBank ID
DB18174
TTD ID
D0E3EO
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Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Pyruvate dehydrogenase kinase (PDHK) TT3UNDH NOUNIPROTAC Inhibitor [3]
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References

1 ClinicalTrials.gov (NCT03789643) Study to Evaluate Efficacy and Safety of JTT-251 in Participants With Pulmonary Arterial Hypertension (RELIEF-PAH). U.S. National Institutes of Health.
2 ClinicalTrials.gov (NCT02106585) Study of Safety, Tolerability and Pharmacokinetics of Single Oral JTT-251 Doses in Healthy and Type 2 Diabetic Subjects. U.S. National Institutes of Health.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)