Details of the Drug

General Information of Drug (ID: DM1AU8V)

• Drug Name: Oxindole derivative
• Synonyms: 5-Fluorooxindole; 56341-41-4; 5-fluoroindolin-2-one; 5-Fluoro-2-oxindole; 5-fluoro-1,3-dihydro-2H-indol-2-one; 5-fluoro-1,3-dihydroindol-2-one; 2H-Indol-2-one, 5-fluoro-1,3-dihydro-; 5-fluoro-2,3-dihydro-1H-indol-2-one; 5-Fluoro-1,3-dihydro-indol-2-one; 5-Fluoro-2-indolinone; 5-Fluoro-2,3-dihydro-2-oxoindole; 5-FLUORO-2-OXYINDOLE; 5-Fluoro-2-oxindole, 97%; MFCD02179598; 5-fluoro indoline-2-one; 5-fluoroindolinone; 5-fluoro-oxindole; 5-fluoro oxindole; zlchem 713; FLUOROOXINDOLE; PubChem1687; ACMC-209lrt; AC1MVD5T

Indication

Disease Entry	ICD 11	Status	REF
Malaria	1F40-1F45	Investigative	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 151.14
  Logarithm of the Partition Coefficient (xlogp); 1.3
  Rotatable Bond Count (rotbonds); 0
  Hydrogen Bond Donor Count (hbonddonor); 1
  Hydrogen Bond Acceptor Count (hbondacc); 2
• Chemical Identifiers:
  Formula: C8H6FNO
  IUPAC Name: 5-fluoro-1,3-dihydroindol-2-one
  Canonical SMILES: C1C2=C(C=CC(=C2)F)NC1=O
  InChI: InChI=1S/C8H6FNO/c9-6-1-2-7-5(3-6)4-8(11)10-7/h1-3H,4H2,(H,10,11)
  InChIKey: DDIIYGHHUMKDGI-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 3731012
  CAS Number: 56341-41-4
  TTD ID: D06YUR
• Drug ADMET Endpoint Profile (DAE)NEW: Click to Jump to the Detailed DAE Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Plasmodium CDK Pfmrk (Malaria Pfmrk)	TTSFWA7	P90584_PLAFA	Inhibitor	[1]

References

• [1] Novel molecular targets for antimalarial chemotherapy. Int J Antimicrob Agents. 2007 Jul;30(1):4-10.