Details of the Drug

General Information of Drug (ID: DM1L5UX)

Drug Name

TAMOLARIZINE HYDROCHLORIDE

Synonyms

NC-1100; Tamolarizine hydrochloride; Rac-alpha-(3,4-Dimethoxyphenyl)-4-(diphenylmethyl)-1-piperazineethanol dihydrochloride; Rac-1-(3,4-Dimethoxyphenyl)-2-(4-diphenylmethyl-1-piperazinyl)ethanol dihydrochloride

Indication

Disease Entry	ICD 11	Status	REF
Cognitive impairment	6D71	Discontinued in Phase 2	[1]

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski):
1

Molecular Weight

505.5

Logarithm of the Partition Coefficient

Not Available

Rotatable Bond Count

8

Hydrogen Bond Donor Count

3

Hydrogen Bond Acceptor Count

5

Chemical Identifiers

Formula: C27H34Cl2N2O3
IUPAC Name: 2-(4-benzhydrylpiperazin-1-yl)-1-(3,4-dimethoxyphenyl)ethanol;dihydrochloride
Canonical SMILES: COC1=C(C=C(C=C1)C(CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4)O)OC.Cl.Cl
InChI: InChI=1S/C27H32N2O3.2ClH/c1-31-25-14-13-23(19-26(25)32-2)24(30)20-28-15-17-29(18-16-28)27(21-9-5-3-6-10-21)22-11-7-4-8-12-22;;/h3-14,19,24,27,30H,15-18,20H2,1-2H3;2*1H
InChIKey: ZIGNSXDSBVYYFD-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 146395
CAS Number: 93035-33-7
TTD ID: D0A4OT

Drug ADMET Endpoint Profile (DAE)^NEW

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Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Calcium channel unspecific (CaC)	TT5HONZ	NOUNIPROTAC	Blocker	[2]

Molecular Interaction Atlas (MIA)

MIA Detail

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000299)
2	Reversal of multidrug resistance in human leukemia K562 by tamolarizine, a novel calcium antagonist. Jpn J Pharmacol. 2000 Mar;82(3):265-8.