Details of the Drug

General Information of Drug (ID: DM1O3BY)

Drug Name

Mecasermin

Synonyms

Increlex (TN)

Indication

Disease Entry	ICD 11	Status	REF
Growth failure	LD2F.1Y	Approved	[1]
Laron syndrome	N.A.	Investigative	[2]
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Therapeutic Class

Immunomodulatory Agents

Affected Organisms

Humans and other mammals

ATC Code

H01AC03: Mecasermin

H01AC: Somatropin and somatropin agonists

H01A: ANTERIOR PITUITARY LOBE HORMONES AND ANALOGUES

H01: PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES

H: SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS

Sequence

GPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMY
CAPLKPAKSA

ADMET Property

Bioavailability: The bioavailability of drug is 100% [3]
Clearance: The clearance of drug is 0.04 L/h/kg []
Half-life: The concentration or amount of drug in body reduced by one-half in 5.8 hours []
Metabolism: The drug is metabolized via the liver and kidney [4]
Vd: The volume of distribution (Vd) of drug is 0.257 +/- 0.073 L/kg []

Cross-matching ID

Repurposed Drugs (RPD)

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Insulin-like growth factor I receptor (IGF1R)	TTHRID2	IGF1R_HUMAN	Inhibitor	[5]

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Molecular Interaction Atlas (MIA)

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Molecular Expression Atlas of This Drug

The Studied Disease

Growth failure

ICD Disease Classification

LD2F.1Y

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Insulin-like growth factor I receptor (IGF1R)	DTT	IGF1R	1.64E-01	0.25	0.64

Molecular Expression Atlas (MEA)

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Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Mecasermin (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Insulin-glulisine	DMQI0FU	Moderate	Increased risk of hypoglycemia by the combination of Mecasermin and Insulin-glulisine.	Acute diabete complication [5A2Y]	[6]
Insulin-aspart	DMX7V28	Moderate	Increased risk of hypoglycemia by the combination of Mecasermin and Insulin-aspart.	Acute diabete complication [5A2Y]	[7]
Insulin-detemir	DMOA4VW	Moderate	Increased risk of hypoglycemia by the combination of Mecasermin and Insulin-detemir.	Type-1/2 diabete [5A10-5A11]	[6]
Insulin degludec	DMPL395	Moderate	Increased risk of hypoglycemia by the combination of Mecasermin and Insulin degludec.	Type-1/2 diabete [5A10-5A11]	[6]
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References

1	Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
2	Cardiac examination in children with Laron syndrome undergoing mecasermin therapy. J Pediatr Endocrinol Metab. 2018 Jun 27;31(6):675-679.
3	Griffith RS: The pharmacology of cephalexin. Postgrad Med J. 1983;59 Suppl 5:16-27.
4	Kabasakalian P, Taggart M, Townley E: Urinary excretion of pheniramine and its N-demthylated metabolites in man--comparison with chlorpheniramine and brompheniramine data. J Pharm Sci. 1968 Apr;57(4):621-3. doi: 10.1002/jps.2600570416.
5	IGF-1R, IGF-1 and IGF-2 expression as potential prognostic and predictive markers in colorectal-cancer. Virchows Arch. 2003 Aug;443(2):139-45.
6	Abad S, Moachon L, Blanche P, Bavoux F, Sicard D, Salmon-Ceron D "Possible interaction between glicazide, fluconazole and sulfamethoxazole resulting in severe hypoglycaemia." Br J Clin Pharmacol 52 (2001): 456-7. [PMID: 11678792]
7	Asplund K, Wiholm BE, Lithner F "Glibenclamide-associated hypoglycaemia: a report on 57 cases." Diabetologia 24 (1983): 412-7. [PMID: 6411511]