Details of the Drug

General Information of Drug (ID: DM25MUA)

Drug Name

SC-56525

Indication

Disease Entry	ICD 11	Status	REF
Hypertension	BA00-BA04	Terminated	[1]
------------------------------------------------------------------------------------

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 0

Molecular Weight (mw)

356.24

Logarithm of the Partition Coefficient (xlogp)

3.5

Rotatable Bond Count (rotbonds)

4

Hydrogen Bond Donor Count (hbonddonor)

1

Hydrogen Bond Acceptor Count (hbondacc)

4

Chemical Identifiers

Formula: C14H14BrNO3S
IUPAC Name: 2-bromo-N-(2-methoxy-6-methylphenyl)benzenesulfonamide
Canonical SMILES: CC1=C(C(=CC=C1)OC)NS(=O)(=O)C2=CC=CC=C2Br
InChI: InChI=1S/C14H14BrNO3S/c1-10-6-5-8-12(19-2)14(10)16-20(17,18)13-9-4-3-7-11(13)15/h3-9,16H,1-2H3
InChIKey: ZENBMAKLSOHDBZ-UHFFFAOYSA-N

Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Angiotensinogenase renin (REN)	TTB2MXP	RENI_HUMAN	Inhibitor	[2]

------------------------------------------------------------------------------------

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004067)
2	Effects of SC-56525, a potent, orally active renin inhibitor, in salt-depleted and renal hypertensive dogs. Hypertension. 1995 Jul;26(1):95-100.