Details of the Drug

General Information of Drug (ID: DM27D4J)

Drug Name
PD-0325901
Synonyms
PD 0325901; PD 325901; PD0325901; PD325901; PD-325901; S06-0029; N-[((R)-2,3-dihydroxypropyl)oxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide; N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodo-phenyl)amino]benzamide; N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Phase 2 [1]
Therapeutic Class
Anticancer Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 482.19
Logarithm of the Partition Coefficient (xlogp) 3
Rotatable Bond Count (rotbonds) 7
Hydrogen Bond Donor Count (hbonddonor) 4
Hydrogen Bond Acceptor Count (hbondacc) 8
Chemical Identifiers
Formula
C16H14F3IN2O4
IUPAC Name
N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide
Canonical SMILES
C1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOC[C@@H](CO)O
InChI
InChI=1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1
InChIKey
SUDAHWBOROXANE-SECBINFHSA-N
Cross-matching ID
PubChem CID
9826528
ChEBI ID
CHEBI:88249
CAS Number
391210-10-9
UNII
86K0J5AK6M
DrugBank ID
DB07101
TTD ID
D0K0YC
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
MAPK/ERK kinase kinase (MAP3K) TTROQ37 NOUNIPROTAC Modulator [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2) OT3K7HY5 DHB2_HUMAN Gene/Protein Processing [3]
5-hydroxytryptamine receptor 7 (HTR7) OT44DEWB 5HT7R_HUMAN Gene/Protein Processing [3]
A-kinase anchor protein 12 (AKAP12) OTCVRDDX AKA12_HUMAN Gene/Protein Processing [3]
ADP-ribosylation factor-like protein 4C (ARL4C) OTQ3QNNU ARL4C_HUMAN Gene/Protein Processing [3]
Aminopeptidase N (ANPEP) OTP3WYFD AMPN_HUMAN Gene/Protein Processing [3]
Anoctamin-1 (ANO1) OTSREUNI ANO1_HUMAN Gene/Protein Processing [3]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Gene/Protein Processing [4]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Gene/Protein Processing [5]
C-C motif chemokine 20 (CCL20) OTUCJY4N CCL20_HUMAN Gene/Protein Processing [3]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Gene/Protein Processing [6]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 41 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1; GDSC2 4.1723 16.3025 -3.9462 17.267
CHSA0011 GDSC1; GDSC2 -0.0279 12.5724 -5.4643 33.2205
U2OS GDSC1; GDSC2; CCLE 0.3768 4.6168 -0.4231 20.4549
MHH-ES-1 GDSC1; GDSC2; CCLE 0.621 2.1133 0.5812 16.032
H-EMC-SS GDSC1; GDSC2 1.7714 9.4625 -2.3801 16.108
CAL-72 GDSC1; GDSC2 1.9531 5.8993 -0.4644 7.1957
G-292 clone A141B1 GDSC1; GDSC2 1.9803 4.0512 0.4594 2.8631
U-CH2 GDSC2 2.4595 5.3644 0.1519 4.6767
EW-24 GDSC1; GDSC2 2.4616 5.1564 0.2509 3.0716
EW-7 GDSC1; GDSC2 2.6559 6.2419 -0.135 4.4912
EW-3 GDSC1; GDSC2 2.9981 5.9587 0.2066 2.5682
ES4 GDSC1; GDSC2 2.9992 7.091 -0.3133 4.7741
EW-22 GDSC1; GDSC2 3.0318 5.4355 0.4547 1.5661
ES7 GDSC1; GDSC2 3.0572 6.2716 0.1 2.9339
SJSA-1 GDSC1; GDSC2; CCLE 3.1054 14.2553 -2.54 21.4568
ES8 GDSC1; GDSC2 3.1107 9.8569 -1.5624 10.0831
CADO-ES1 GDSC1; GDSC2 3.1363 5.1119 0.6408 0.8447
SK-PN-DW GDSC1; GDSC2 3.2613 7.4668 -0.324 4.4563
EW-18 GDSC1; GDSC2 3.3628 5.9622 0.401 1.4597
EW-13 GDSC1; GDSC2 3.4421 5.4638 0.6394 0.6589
HuO-3N1 GDSC1; GDSC2 3.4826 5.6831 0.5715 0.8247
NY GDSC1; GDSC2 3.5948 7.4309 -0.1109 3.1598
CHSA8926 GDSC1; GDSC2 3.6063 12.9435 -2.7126 13.9048
EW-1 GDSC1; GDSC2 3.7371 11.4428 -1.8946 10.443
ES1 GDSC1; GDSC2 3.8225 10.455 -1.3666 8.1113
EW-12 GDSC2 3.8319 5.6369 0.7334 0.3794
EW-16 GDSC1; GDSC2 3.9252 12.2753 -2.1664 11.2408
EW-11 GDSC1; GDSC2 3.9979 6.88 0.3301 1.2067
CAL-78 GDSC1; GDSC2; CCLE 4.2554 6.5793 2.1167 1.882
HuO9 GDSC1; GDSC2 4.358 10.936 -1.2522 6.8767
CHSA0108 GDSC1; GDSC2 4.8494 16.2034 -3.4239 16.1582
SaOS-2 GDSC1; GDSC2; CCLE 4.9571 7.29 2.1832 1.0426
TC-71 GDSC1; GDSC2; CCLE 5.1194 6.9848 2.3773 0.4491
ES5 GDSC1; GDSC2 5.1977 8.127 0.3619 0.5336
SK-ES-1 GDSC1; GDSC2; CCLE 5.3128 7.143 2.3971 0.3361
NOS-1 [Human HNSCC] GDSC1; GDSC2 5.3413 14.6873 -2.3818 9.9691
HOS GDSC1; GDSC2; CCLE 5.684 12.1639 0.4151 6.6162
ES6 GDSC1; GDSC2 5.8321 16.6016 -2.9659 11.4067
SW1353 CCLE 5.8577 17.6072 -2.0807 18.229
MG-63 GDSC1; GDSC2; CCLE 7.2954 19.8222 -2.1568 13.4191
A-673 GDSC1; GDSC2; CCLE 8.5127 21.4752 -2.1471 11.8545
⏷ Show the Full List of 41 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 195 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1; GDSC2 4.0897 6.0541 0.6822 0.3493
OCI-AML-2 GDSC1; GDSC2; CCLE -8.3431 -6.3419 -8.3431 75.6844
NB4 GDSC1; GDSC2 -8.298 -0.3022 -8.7819 71.5419
KO52 CCLE -7.4076 11.432 -11.406 62.6117
OCI-AML-3 GDSC1; GDSC2 -7.0674 -0.6573 -7.3791 60.5873
KMOE-2 GDSC1; GDSC2 -7.0417 -4.1736 -7.046 62.7385
SKM-1 GDSC1; GDSC2 -6.9553 -0.1107 -7.3643 59.6062
NOMO-1 GDSC1; GDSC2 -6.1909 6.5342 -8.7162 53.3844
HL-60 GDSC1; GDSC2 -5.6904 1.8901 -6.4932 52.0685
HuT 78 CCLE -5.5925 -1.3588 -5.6366 70.8956
H9 GDSC1; GDSC2 -5.3339 1.1931 -5.907 50.0752
JURL-MK1 GDSC1; GDSC2 -5.3133 -1.5343 -5.3844 49.9404
HD-MY-Z CCLE -5.126 0.8837 -5.3929 65.2306
IM-9 GDSC1; GDSC2 -4.8024 0.6019 -5.1798 46.5874
Ku812 GDSC1; GDSC2; CCLE -4.5513 0.4613 -4.7121 50.4265
KY821 GDSC1; GDSC2 -4.3271 6.8317 -6.8936 45.7103
ML-2 GDSC1; GDSC2 -3.9175 2.5009 -4.7565 41.46
MV4-11 GDSC1; GDSC2 -3.3948 0.7183 -3.6742 36.4457
LAMA-84 GDSC1; GDSC2 -3.3359 -0.2951 -3.4284 35.3891
EoL-1 GDSC1; GDSC2 -3.283 1.2366 -3.6805 36
PL-21 GDSC1; GDSC2 -2.977 8.5124 -6.2751 44.0828
Kasumi-1 GDSC2 -2.8551 1.0055 -3.1543 32.537
EM-2 GDSC1; GDSC2; CCLE -2.7278 5.5698 -4.1018 41.1841
NCO2 CCLE -2.4839 1.2462 -2.6131 47.2803
MEG-01 GDSC1; GDSC2; CCLE -2.4049 2.5277 -2.7765 37.1992
OCI-AML-5 GDSC1; GDSC2; CCLE -1.9809 3.666 -2.6312 35.244
KOPN-8 GDSC1; GDSC2 -1.9692 7.6612 -4.8825 34.3114
NCI-H929 GDSC1; GDSC2 -1.8977 3.7117 -3.0438 28.6556
MOLM-13 GDSC1; GDSC2 -1.8091 0.8837 -1.9862 24.2528
OCI-M1 GDSC1; GDSC2 -1.6978 1.7877 -2.1116 24.3672
BV-173 GDSC1; GDSC2 -1.597 3.4186 -2.6073 26.0055
Karpas-620 GDSC1; GDSC2; CCLE -1.4957 8.2975 -3.9372 36.5865
NKM-1 GDSC1; GDSC2 -1.455 7.0533 -4.0929 30.6154
F-36P CCLE -1.415 19.905 -9.3647 46.4857
U266B1 GDSC1; GDSC2 -1.2665 6.7247 -3.7539 29.0035
P31/FUJ GDSC1; GDSC2; CCLE -1.2191 6.3639 -2.8173 33.1429
OCI-Ly7 GDSC1; GDSC2 -1.0851 -0.3681 -1.0855 21.2618
TALL-1 [Human adult T-ALL] GDSC2 -0.9743 11.591 -5.8326 39.1135
BDCM CCLE -0.864 14.4558 -6.1981 43.3975
KCL-22 GDSC1; GDSC2; CCLE -0.7674 4.2692 -1.5167 27.7664
JSC-1 GDSC1; GDSC2 -0.75 8.812 -4.2643 29.0196
MOLT-13 GDSC1; GDSC2 -0.2439 8.6308 -3.7074 25.9055
CML-T1 GDSC1; GDSC2 -0.1452 4.5383 -1.6278 17.5097
MOLM-16 GDSC1; GDSC2 -0.0586 12.1447 -5.279 32.9025
A4/Fukuda GDSC1; GDSC2 -0.0463 10.2981 -4.3519 27.3703
KG-1 GDSC1; GDSC2; CCLE 0.0383 5.1315 -0.9886 23.5118
A3/Kawakami GDSC1; GDSC2 0.0383 6.4548 -2.3796 20.2338
SUP-B15 GDSC1; GDSC2 0.1035 5.4952 -1.8505 17.815
JVM-3 GDSC1; GDSC2; CCLE 0.1647 11.4574 -3.7742 31.4702
ME1 GDSC1; GDSC2 0.2056 19.1663 -8.5468 35.1713
SU-DHL-1 GDSC2 0.2429 6.0171 -1.976 23.3633
HAL-01 GDSC1; GDSC2 0.3768 7.988 -2.8282 21.1403
Mono-Mac-6 GDSC1; GDSC2 0.5486 4.738 -1.0668 13.1294
CMK GDSC1 0.5563 1.9889 -2.4584 0.16
EHEB GDSC1 0.6634 10.432 -6.1606 19.4983
SIG-M5 GDSC2; CCLE 0.6719 1.4176 0.6711 19.9977
KMM-1 CCLE 0.774 8.5886 -1.8129 30.1134
AMO1 GDSC1; GDSC2; CCLE 0.8076 11.0416 -2.9677 27.8096
K-562 GDSC1; GDSC2 0.8754 7.6289 -2.211 17.4238
VL51 GDSC1; GDSC2 0.9088 11.2656 -3.9983 23.9397
MHH-CALL-4 GDSC2 0.9194 10.6365 -3.6749 27.9936
THP-1 GDSC1; GDSC2 0.9917 12.0161 -4.3028 27.5016
BONNA-12 GDSC2 1.2304 10.0242 -3.1057 25.0303
Sc-1 GDSC1 1.2635 2.6268 -2.4317 0.0402
RPMI-8226 GDSC1; GDSC2 1.4233 11.5901 -3.728 21.8821
SR GDSC1; GDSC2 1.5541 5.7991 -0.7262 9.2178
Karpas-299 GDSC1; GDSC2; CCLE 1.5903 7.4557 -0.4895 17.5785
WIL2 NS GDSC1; GDSC2 1.6107 4.6208 -0.0935 6.1168
JVM-2 GDSC1; GDSC2 1.6217 7.6114 -1.5767 12.9842
MY-M12 GDSC1; GDSC2 1.691 14.8912 -5.1577 28.0904
ST486 GDSC1; GDSC2 1.7235 8.2941 -1.8354 13.9095
RPMI-6666 GDSC1; GDSC2 1.7375 8.7675 -2.0605 14.848
OCI-Ly19 GDSC1; GDSC2 1.7735 15.6326 -5.4606 28.6459
U-937 CCLE 2.0021 7.8216 -0.2857 20.0479
HC-1 GDSC1; GDSC2 2.0053 11.5413 -3.23 18.8894
NK-92MI GDSC2 2.015 5.0569 -0.0042 6.5769
GDM-1 GDSC1; GDSC2 2.0201 7.5491 -1.2307 10.6088
KE-37 GDSC1; GDSC2 2.0244 5.993 -0.4572 7.0287
SU-DHL-16 GDSC1; GDSC2 2.0305 5.0077 0.031 5.5689
OPM-2 GDSC1; GDSC2; CCLE 2.0494 7.0169 0.1531 13.9485
LC4-1 GDSC1; GDSC2 2.0728 7.3391 -1.0861 9.8469
TUR GDSC1; GDSC2 2.0842 4.9053 0.1189 4.2487
PF-382 GDSC1; GDSC2 2.1457 5.5049 -0.1291 5.2872
KHM-1B CCLE 2.1591 21.2725 -6.8461 36.525
SUP-HD1 GDSC1; GDSC2 2.1965 6.0231 -0.3457 6.1994
SUP-M2 GDSC1; GDSC2; CCLE 2.1967 6.2406 0.6697 11.4934
P12-Ichikawa GDSC1; GDSC2; CCLE 2.2758 13.4057 -2.8181 23.992
CESS GDSC1; GDSC2 2.2951 8.9815 -1.7301 12.2941
Farage GDSC1; GDSC2 2.3104 10.3824 -2.4132 15.1327
CTV-1 GDSC1; GDSC2 2.3246 6.5643 -0.5179 6.7688
NALM-6 GDSC1; GDSC2 2.3621 9.5894 -1.9801 13.2374
ATN-1 GDSC1; GDSC2 2.3658 5.0545 0.2374 3.2688
P32/ISH GDSC1; GDSC2 2.3814 3.9814 0.7368 1.1499
MOLP-8 GDSC1; GDSC2; CCLE 2.3986 12.9558 -2.4876 22.7509
RC-K8 GDSC1; GDSC2 2.4814 5.1659 0.2589 3.0088
Mono-Mac-1 CCLE 2.4924 13.8567 -2.8569 28.1424
Namalwa GDSC1; GDSC2 2.5624 5.7677 0.0283 3.9056
Loucy GDSC1; GDSC2 2.5759 5.6557 0.0897 3.6153
WSU-NHL GDSC1; GDSC2 2.5885 9.0442 -1.5412 10.9152
BC-1 GDSC1; GDSC2 2.6055 8.1322 -1.0818 8.8434
Hs 445 GDSC2 2.6109 8.0709 -1.048 8.6822
ARH-77 GDSC1; GDSC2 2.6277 7.2199 -0.6225 6.7301
DB GDSC1; GDSC2 2.6579 5.91 0.0228 3.7913
Jiyoye GDSC1; GDSC2 2.6865 5.2755 0.3333 2.4221
SK-MM-2 GDSC1; GDSC2; CCLE 2.6898 9.4258 -0.4749 15.0906
Daudi GDSC1; GDSC2 2.6963 4.9893 0.4673 1.8647
SCC-3 GDSC2 2.7017 7.4775 -0.6957 6.9382
SUP-B8 GDSC1; GDSC2 2.7266 4.4536 0.7139 1.075
WSU-DLCL2 GDSC1; GDSC2 2.7303 6.9805 -0.4371 5.7277
697 GDSC1; GDSC2; CCLE 2.7474 9.0425 -0.2342 14.0204
GA-10 GDSC1; GDSC2 2.7675 5.8019 0.1413 3.1273
KMS-26 CCLE 2.7745 9.6786 -0.529 18.987
JeKo-1 GDSC1; GDSC2 2.7995 4.2706 0.8219 0.6175
DEL GDSC1; GDSC2; CCLE 2.8151 9.4679 -0.3893 14.4987
Ramos.2G6.4C10 GDSC1; GDSC2 2.8368 7.2109 -0.4759 5.7351
BE-13 GDSC1; GDSC2 2.8372 6.4738 -0.1273 4.1924
DG-75 GDSC1; GDSC2 2.8401 6.0554 0.0689 3.3401
MHH-CALL-2 GDSC1; GDSC2 2.8771 9.9673 -1.7831 11.4368
BALL-1 GDSC1; GDSC2 2.8824 4.952 0.5832 1.2379
VAL GDSC1; GDSC2 2.885 6.2082 0.0259 3.4643
NU-DUL-1 GDSC1; GDSC2 2.8932 7.7683 -0.7045 7.7896
MN-60 GDSC1; GDSC2 2.9854 6.0039 0.1789 2.696
U-698-M GDSC1; GDSC2 3.0131 5.7602 0.3033 2.1637
GR-ST GDSC1; GDSC2 3.0447 5.9277 0.2469 2.3526
RL GDSC1; GDSC2 3.0575 4.5265 0.8341 0.4246
MHH-PREB-1 GDSC1; GDSC2 3.1017 4.9885 0.6743 0.7663
Karpas-231 GDSC1; GDSC2 3.1169 4.4058 0.9017 0.2023
SU-DHL-5 GDSC1; GDSC2 3.1389 11.5757 -2.3809 13.435
MM1.S GDSC1; GDSC2 3.1467 16.0428 -4.5786 21.0406
YT GDSC1; GDSC2 3.1569 10.1688 -1.6812 10.5128
ALL-SIL GDSC1; GDSC2; CCLE 3.1597 8.2347 0.5146 10.1515
Raji GDSC1; GDSC2; CCLE 3.1611 4.7033 2.2786 2.7436
RS4;11 GDSC1; GDSC2 3.1735 6.1165 0.2352 2.2572
HDLM-2 GDSC1; GDSC2 3.178 7.8051 -0.5341 5.4809
CA46 GDSC1; GDSC2 3.2013 5.5036 0.5119 1.2135
RPMI-8866 GDSC1; GDSC2 3.2342 9.8241 -1.4603 9.4365
CTB-1 GDSC1; GDSC2 3.2509 5.5941 0.4988 1.4292
SU-DHL-10 GDSC1; GDSC2; CCLE 3.2675 7.8146 0.8119 8.7115
BC-3 GDSC2 3.3775 5.0435 0.7716 0.4896
QIMR-WIL GDSC1; GDSC2 3.3929 15.4925 -4.1202 21.3268
HEL GDSC1; GDSC2 3.3997 4.8092 0.8648 0.1857
Karpas-45 GDSC1; GDSC2 3.4016 7.736 -0.3623 4.4324
LP-1 GDSC1; GDSC2; CCLE 3.4045 4.9709 2.3279 2.1396
SU-DHL-8 GDSC1; GDSC2; CCLE 3.489 6.2558 1.7595 4.3562
EJM GDSC1; GDSC2 3.5083 10.2444 -1.475 9.0545
MC116 GDSC1; GDSC2; CCLE 3.5087 6.7022 1.5538 5.9624
CRO-AP2 GDSC1; GDSC2 3.5676 5.561 0.6557 0.6474
TK [Human B-cell lymphoma] GDSC1; GDSC2 3.6022 5.0001 0.8722 0.1311
CCRF-CEM GDSC1; GDSC2 3.619 6.2169 0.4206 1.1916
L-540 GDSC1; GDSC2 3.6324 6.2414 0.4169 1.1935
ALL-PO GDSC1; GDSC2 3.6918 10.748 -1.5924 9.2605
MOLT-4 GDSC1; GDSC2 3.729 10.62 -1.5065 8.8423
KM-H2 GDSC1; GDSC2 3.7437 7.3559 0.004 2.5526
Granta-519 GDSC1; GDSC2; CCLE 3.8413 8.057 1.1338 6.3781
MEC-1 CCLE 3.8423 15.5128 -2.5691 23.993
L-1236 GDSC1; GDSC2 3.8517 6.6584 0.3512 1.243
OCI-Ly10 CCLE 3.8804 9.5981 0.4029 11.8476
Toledo CCLE 3.9869 10.3659 0.1037 13.0837
KMS-34 CCLE 4.0203 5.4488 2.485 1.056
SU-DHL-4 GDSC1; GDSC2; CCLE 4.022 5.4484 2.486 0.9403
RCH-ACV GDSC1; GDSC2 4.0396 6.084 0.6522 0.4314
MLMA GDSC1; GDSC2 4.0879 16.6473 -4.1757 18.1386
P30/OHK GDSC1; GDSC2 4.1967 5.6695 0.8527 0.0687
MOLT-16 GDSC1; GDSC2; CCLE 4.2102 5.8618 2.4074 0.9153
Pfeiffer CCLE 4.2698 11.7481 -0.3661 14.6631
P3HR-1 CCLE 4.3459 9.5049 0.7895 8.935
ROS-50 GDSC1; GDSC2 4.423 6.1773 0.7603 0.1436
Jurkat GDSC1; GDSC2; CCLE 4.4295 6.9512 2.0502 1.9396
EB1 CCLE 4.4482 10.3723 0.44 10.4771
Karpas-1106P GDSC1; GDSC2 4.4601 13.1504 -2.2259 10.6427
HEL 92.1.7 CCLE 4.4671 8.9633 1.1346 6.9584
HT GDSC1; GDSC2; CCLE 4.4941 10.0187 0.6444 8.4404
Ci-1 CCLE 4.5162 5.5194 2.6753 0.1392
JJN-3 GDSC1; GDSC2 4.6388 14.2432 -2.6274 11.9059
DND-41 GDSC1; GDSC2 4.6629 16.5233 -3.7067 15.6776
BL-41 GDSC1; GDSC2; CCLE 4.6986 6.9603 2.1922 1.2081
BL-70 CCLE 4.7383 5.7856 2.6635 0.1053
KMS-11 GDSC1; GDSC2; CCLE 4.7513 10.3317 0.671 7.8862
DoHH2 GDSC1; GDSC2; CCLE 4.7562 6.2945 2.4868 0.366
Kasumi-2 CCLE 4.9891 22.004 -4.8994 27.5507
SUP-T1 GDSC1; GDSC2; CCLE 4.9896 6.9885 2.3197 0.6467
CMK-86 CCLE 5.0402 7.73 2.0409 1.8191
Reh GDSC1; GDSC2; CCLE 5.144 6.7936 2.4583 0.2806
L-363 GDSC1; GDSC2; CCLE 5.1511 6.4271 2.5904 0.0944
EB2 GDSC1; GDSC2; CCLE 5.1625 7.0231 2.3807 0.4239
RPMI-8402 GDSC1; GDSC2; CCLE 5.195 7.8804 2.0554 1.2541
JM-1 CCLE 5.4685 7.0844 2.4775 0.2164
MJ CCLE 5.4959 8.3494 2.0081 1.5231
KMS-12-BM GDSC2; CCLE 5.6554 6.9928 2.5742 0.0515
L-428 GDSC1; GDSC2; CCLE 5.725 7.1732 2.5379 0.07
Mino CCLE 5.7316 17.5415 -2.139 18.6636
HH [Human lymphoma] GDSC1; GDSC2; CCLE 6.1187 8.0531 2.3771 0.1679
KE-97 CCLE 6.3596 16.3425 -1.1218 13.818
Karpas-422 GDSC1; GDSC2; CCLE 6.9136 16.0675 -0.6314 8.8866
SU-DHL-6 GDSC1; GDSC2; CCLE 8.1815 21.3516 -2.3005 12.715
⏷ Show the Full List of 195 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-GT-4 GDSC1; GDSC2 -1.7081 12.5744 -6.9933 37.4495
OACP4 C GDSC1; GDSC2 -1.1251 8.1505 -4.2975 30.1988
ESO-51 GDSC1; GDSC2 -0.578 3.3607 -1.5218 18.2898
KYSE-220 GDSC1; GDSC2 0.9603 10.1821 -3.413 21.8653
FLO-1 GDSC1; GDSC2 1.6268 14.6334 -5.0815 25.4758
TE-12 GDSC1; GDSC2 1.9294 13.7317 -4.3843 22.8666
KYSE-50 GDSC1; GDSC2 2.0163 5.8039 -0.3699 6.637
OACM5.1 C GDSC1; GDSC2 2.8017 7.1909 -0.4898 5.8516
ESO-26 GDSC1; GDSC2 3.1511 7.3829 -0.3536 4.7346
KYAE-1 GDSC1; GDSC2 4.1064 5.9839 0.7134 0.2426
HCE-4 GDSC1; GDSC2 5.0508 16.0458 -3.2122 15.0362
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1; GDSC2 3.614 6.5639 0.2748 1.6841
Cancer Drug Sensitivity Data Curated from 35 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CHP-212 GDSC1; GDSC2; CCLE -9.1306 -1.3985 -9.3478 73.1099
NB69 GDSC1; GDSC2 -5.2395 1.3685 -5.8516 49.5049
KP-N-SI9s CCLE -2.5483 6.622 -4.3213 48.5841
SK-N-AS GDSC1; GDSC2; CCLE -2.3965 7.8796 -4.6839 40.8295
NB(TU)1 GDSC1; GDSC2 -2.1035 2.2576 -2.708 28.1243
LA-N-6 GDSC1; GDSC2 -1.6311 6.4127 -3.9668 34.8846
SK-N-BE(2)-M17 GDSC1; GDSC2 -0.9771 4.9803 -2.6548 24.226
NH-12 GDSC1; GDSC2 -0.555 6.4703 -2.9454 24.096
SJNB-5 GDSC1; GDSC2 -0.2308 7.2746 -3.0303 26.8623
CHP-134 GDSC1; GDSC2 0.4587 2.0661 -2.5197 0.2505
SK-N-FI GDSC1; GDSC2; CCLE 0.6849 10.6112 -2.8731 27.8583
SiMa GDSC1; GDSC2; CCLE 0.6877 9.7292 -2.4434 26.6145
SK-N-BE(2) CCLE 0.7935 11.3813 -3.1467 33.7743
SJNB-10 GDSC1; GDSC2 1.4429 13.1546 -4.4939 24.2358
MHH-NB-11 GDSC1; GDSC2 1.664 8.725 -2.0985 17.4602
GI-ME-N GDSC1; GDSC2 1.7723 12.5203 -3.9065 21.7066
KP-N-YN GDSC1; GDSC2 1.8357 9.9255 -2.5596 16.696
TGW GDSC1; GDSC2 2.3192 11.5422 -2.9828 17.3334
SJNB-14 GDSC1; GDSC2 2.3381 9.6134 -2.0104 13.4123
NB1 GDSC1; GDSC2 2.5252 6.5994 -0.3938 5.8617
IMR-5 GDSC1; GDSC2 2.6813 5.4093 0.2693 2.6968
SK-N-MC-IXC GDSC1; GDSC2 2.7838 3.9328 0.9437 0.2739
GOTO GDSC1; GDSC2 3.0493 5.5373 0.4202 1.6773
CHP-126 GDSC1; GDSC2 3.1119 5.2208 0.585 1.2209
IMR-32 CCLE 3.1499 6.1586 1.5439 8.7836
SJNB-6 GDSC1; GDSC2 3.2289 5.6201 0.4771 1.5368
Kelly GDSC1; GDSC2; CCLE 3.3007 11.6842 -1.0941 16.2255
SJNB-13 GDSC1; GDSC2 3.3292 6.3228 0.2298 2.1157
SK-N-SH GDSC1; GDSC2; CCLE 3.4293 9.6744 0.0135 11.7002
SJNB-7 GDSC1; GDSC2 3.5334 5.5816 0.6333 0.6255
KP-N-RT-BM-1 GDSC2 3.7967 6.0308 0.5735 0.8576
KP-N-YS GDSC1; GDSC2 4.0338 12.8711 -2.3787 13.5607
SJNB-17 GDSC1; GDSC2 4.1477 6.1886 0.6562 0.3825
SJNB-12 GDSC1; GDSC2 4.3694 6.5712 0.6037 0.352
SK-N-DZ GDSC1; GDSC2; CCLE 5.3347 12.2763 0.1337 8.1535
⏷ Show the Full List of 35 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1; GDSC2; CCLE 0.339 10.7299 -3.2576 29.7695
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU4475 GDSC1; GDSC2 -8.0539 -6.7358 -8.0539 70.5575
HMC-1-8 CCLE -3.749 5.2906 -5.0972 54.8371
MDA-MB-231 GDSC1; GDSC2 0.1315 8.0105 -3.0598 22.6472
CAL-85-1 GDSC1; GDSC2; CCLE 0.4863 6.7821 -1.2482 23.2095
HCC202 GDSC1 0.9321 2.9562 -2.6575 0.4678
ZR-75-1 CCLE 1.5167 11.8663 -2.7228 30.4815
UACC-893 GDSC1; GDSC2 1.5248 8.1944 -1.9467 19.0623
MFM-223 GDSC1; GDSC2 1.6616 4.7978 -0.1417 6.243
MDA-MB-175-VII GDSC1; GDSC2; CCLE 1.6698 7.8344 -0.599 17.8168
HCC1143 GDSC1; GDSC2 1.6817 13.7876 -4.6137 24.0657
HDQ-P1 GDSC1; GDSC2; CCLE 1.9213 12.2248 -2.5395 23.9495
CAL-120 GDSC1; GDSC2 1.922 5.1394 -0.1127 5.6098
MDA-MB-453 GDSC1; GDSC2; CCLE 2.0302 5.2416 0.9953 10.5373
HCC1806 GDSC1; GDSC2; CCLE 2.3097 13.1143 -2.6433 23.4082
CAL-148 GDSC2 2.3719 4.8576 0.3338 2.8361
HCC1428 GDSC1; GDSC2 2.4139 5.2191 0.1909 3.4043
Evsa-T GDSC1; GDSC2 2.53 4.4932 0.5939 1.5474
JIMT-1 GDSC1; GDSC2 2.5638 8.5254 -1.3046 9.9152
HCC2157 GDSC1; GDSC2 2.572 5.2342 0.2834 2.7798
EFM-192A GDSC1; GDSC2 2.7499 5.9539 0.0602 3.4993
HCC1500 GDSC1; GDSC2 2.8857 5.6825 0.2658 2.4594
YMB-1-E GDSC2 2.9353 6.0706 0.1193 4.0021
UACC-812 GDSC2; CCLE 2.973 6.897 1.0289 8.3597
OCUB-M GDSC1; GDSC2 3.0186 9.1317 -1.2753 8.992
MCF-7 GDSC1; GDSC2; CCLE 3.111 5.8909 1.6459 5.4975
HCC1954 GDSC1; GDSC2; CCLE 3.1349 9.3691 -0.0728 12.604
HCC38 GDSC1; GDSC2 3.2167 5.1019 0.6813 0.6733
COLO 824 GDSC1; GDSC2 3.2819 6.9274 -0.065 3.3408
Hs 739.T CCLE 3.2903 12.2698 -1.3953 21.2603
MDA-MB-468 GDSC1; GDSC2; CCLE 3.4355 15.969 -3.1252 22.5139
MRK-nu-1 GDSC1; GDSC2 3.5121 11.301 -1.9812 11.1674
BT-474 GDSC1; GDSC2; CCLE 3.5545 6.1311 1.869 3.7961
HCC1419 GDSC1; GDSC2 3.593 8.4624 -0.58 5.1
BT-483 GDSC1; GDSC2 3.9338 5.86 0.6923 0.327
HCC2218 GDSC1; GDSC2 4.044 6.565 0.4744 0.9034
CAL-51 GDSC1; GDSC2 4.1157 13.0533 -2.4104 11.8956
HCC1599 GDSC2 4.1319 5.581 0.8602 0.0927
CAMA-1 GDSC1; GDSC2; CCLE 4.237 9.316 0.8042 7.106
HCC1569 GDSC1; GDSC2; CCLE 4.3262 12.403 -0.6472 12.7023
MDA-MB-330 GDSC1; GDSC2 4.3979 6.5306 0.629 0.3008
HCC1937 GDSC1; GDSC2 4.4481 13.446 -2.3744 11.2367
HCC1395 GDSC1; GDSC2; CCLE 4.7495 12.5205 -0.3926 11.043
BT-549 GDSC1; GDSC2; CCLE 4.8699 9.0405 1.3594 4.0226
HCC70 GDSC1; GDSC2; CCLE 5.0092 18.3525 -3.0728 19.5606
MDA-MB-157 GDSC1; GDSC2; CCLE 5.0584 13.4844 -0.6415 11.4958
Hs 578T GDSC1; GDSC2; CCLE 5.1675 21.6576 -4.5897 23.1698
EFM-19 GDSC1; GDSC2; CCLE 5.1707 7.82 2.0685 1.2321
ZR-75-30 GDSC1; GDSC2; CCLE 5.2133 7.2703 2.3081 0.5621
SK-BR-3 CCLE 5.2817 7.361 2.3025 0.6983
BT-20 GDSC1; GDSC2; CCLE 5.7359 17.9673 -2.3442 16.2391
MDA-MB-361 GDSC1; GDSC2 5.8149 15.6393 -2.5289 9.8729
T-47D GDSC1; GDSC2; CCLE 5.8411 8.3501 2.162 0.6089
MDA-MB-415 GDSC1; GDSC2; CCLE 5.9887 13.7051 -0.1138 8.2032
AU565 GDSC1; GDSC2; CCLE 6.12 8.1057 2.3594 0.1883
HCC1187 GDSC1; GDSC2; CCLE 6.6555 18.851 -2.1247 14.1975
MDA-MB-436 GDSC1; GDSC2; CCLE 6.9643 17.9613 -1.4908 11.7405
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 59 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ONS-76 GDSC1; GDSC2; CCLE -3.0636 5.1459 -4.3065 42.8102
AM-38 GDSC1; GDSC2 -0.9802 6.4202 -3.3311 26.7325
D-245MG GDSC2 0.6428 4.4535 -0.8405 15.7209
MOG-G-UVW GDSC1; GDSC2 1.1054 7.2057 -1.8023 15.1267
D-502MG GDSC1; GDSC2 1.2769 15.5443 -5.8268 30.6496
KS-1 [Human Krukenberg tumour] GDSC1; GDSC2 1.377 8.4382 -2.1904 16.1807
GB-1 GDSC1; GDSC2; CCLE 1.4164 3.6848 1.0462 11.9292
KALS-1 GDSC1; GDSC2; CCLE 1.463 11.308 -2.4954 24.8678
D-247MG GDSC1; GDSC2 1.6837 5.4999 -0.4738 9.1003
DBTRG-05MG GDSC1; GDSC2; CCLE 1.9776 14.918 -3.8311 27.3168
LN-405 GDSC1; GDSC2 2.2228 5.9203 -0.2766 5.8346
SNB-75 GDSC1; GDSC2 2.4334 7.136 -0.7189 8.7681
42-MG-BA GDSC1; GDSC2; CCLE 2.5385 9.3287 -0.5567 15.7251
KNS-60 CCLE 2.6287 12.8855 -2.2555 25.9825
SW1783 GDSC1; GDSC2 2.6312 6.5818 -0.3131 5.3265
YH-13 GDSC1; GDSC2 2.6719 6.1841 -0.0972 4.2998
DK-MG GDSC1; GDSC2; CCLE 2.6993 12.5835 -2.0446 20.7248
D-566MG GDSC1; GDSC2 2.729 4.6548 0.6306 1.4166
SF539 GDSC1; GDSC2 2.8032 11.6768 -2.6788 15.2275
U-87MG ATCC GDSC1; GDSC2; CCLE 2.8191 10.1451 -0.7244 15.7929
1321N1 CCLE 2.8769 7.3853 0.7039 12.6873
D283 Med GDSC1; GDSC2 3.006 12.3285 -2.8487 15.4977
CAS-1 GDSC1; GDSC2; CCLE 3.015 8.0107 0.5071 10.46
D-336MG GDSC2 3.0371 5.4656 0.4445 2.1312
SF126 GDSC1; GDSC2; CCLE 3.0739 10.0056 -0.4414 16.1565
SF295 GDSC1; GDSC2; CCLE 3.1801 9.9454 -0.3238 15.4091
KNS-81-FD GDSC1; GDSC2 3.3603 10.4575 -1.6788 11.7178
U-251MG GDSC1; GDSC2 3.3641 12.0058 -2.4285 13.2247
YKG-1 GDSC1; GDSC2; CCLE 3.3745 9.303 0.1549 12.8507
KINGS-1 GDSC1; GDSC2 3.3762 15.9826 -4.3747 20.0078
Hs 683 GDSC1; GDSC2; CCLE 3.3792 8.5412 0.5387 11.0663
Onda 11 GDSC1; GDSC2 3.4887 11.3043 -1.9992 12.9427
LN-229 GDSC1; GDSC2; CCLE 3.5084 15.0602 -2.6119 20.8896
D-392MG GDSC1; GDSC2 3.6549 14.8937 -3.6315 17.1224
D-263MG GDSC1; GDSC2 3.6612 15.8654 -4.1043 18.6569
Becker GDSC1; GDSC2 3.7241 15.6602 -3.9571 18.0757
KNS-42 GDSC1; GDSC2; CCLE 3.8525 9.5045 0.428 10.6165
KNS-81 CCLE 3.8779 15.2544 -2.4118 23.418
GI-1 GDSC1; GDSC2; CCLE 3.9517 10.372 0.074 10.528
SW1088 GDSC1; GDSC2; CCLE 4.028 9.1172 0.7501 7.6559
D-542MG GDSC1; GDSC2 4.0673 20.8622 -6.2652 25.8069
Onda 10 GDSC1; GDSC2 4.1514 11.9071 -1.8391 10.9934
A-172 GDSC2; CCLE 4.1566 11.2889 -0.2244 11.3624
PFSK-1 GDSC1; GDSC2 4.4279 14.4059 -2.8475 13.0505
GMS-10 CCLE 4.4805 10.9521 0.1802 11.6743
NMC-G1 GDSC1; GDSC2 4.5921 17.6692 -4.3127 19.6108
D-423MG GDSC1; GDSC2 4.6438 14.3226 -2.6619 13.6246
M059J GDSC1; GDSC2; CCLE 4.6912 7.8654 1.7904 2.6079
H4 GDSC1; GDSC2; CCLE 4.9011 12.6783 -0.3608 10.6847
Daoy GDSC1; GDSC2; CCLE 5.0261 11.2958 0.395 7.575
MOG-G-CCM GDSC1; GDSC2; CCLE 5.0295 9.8067 1.1027 4.8119
8-MG-BA GDSC1; GDSC2; CCLE 5.184 11.9752 0.1762 8.2018
U-118MG GDSC1; GDSC2; CCLE 5.2192 12.7956 -0.1944 9.5725
GaMG GDSC1; GDSC2; CCLE 5.23 12.1512 0.1229 8.342
T98G GDSC1; GDSC2; CCLE 5.3506 11.2767 0.6183 6.2689
SF268 GDSC1; GDSC2 5.7241 15.1066 -2.3387 9.2969
SK-MG-1 GDSC1; GDSC2 5.9381 19.7255 -4.3753 15.8411
LNZTA3WT4 GDSC1; GDSC2 6.9506 22.9731 -5.2485 16.895
LN-18 GDSC1; GDSC2; CCLE 7.487 22.4305 -3.2778 16.408
⏷ Show the Full List of 59 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC1TKB GDSC1; GDSC2 2.7561 8.7388 -1.2699 9.4183
ETK-1 GDSC1; GDSC2 2.8466 6.6403 -0.1993 4.4947
TGBC24TKB GDSC1; GDSC2 3.2992 11.1455 -2.0554 11.8337
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HEC-151 CCLE -2.9244 10.608 -6.4211 50.3875
RL95-2 GDSC1; GDSC2; CCLE -1.0061 8.0267 -3.3178 33.7184
MFE-319 GDSC1; GDSC2; CCLE 1.7323 9.3851 -1.3021 20.2994
JHUEM-2 CCLE 2.402 5.1398 1.3984 10.2894
HEC-1-B CCLE 2.5098 16.6006 -4.213 31.4083
MFE-296 GDSC1; GDSC2; CCLE 2.9723 6.0818 1.436 6.6475
ESS-1 GDSC1; GDSC2; CCLE 2.9926 7.4826 0.7526 9.4805
HEC-1-A CCLE 3.1741 16.2144 -3.4627 28.0649
AN3-CA GDSC1; GDSC2; CCLE 3.3543 8.9284 0.3256 10.5676
MFE-280 GDSC1; GDSC2; CCLE 3.3948 8.6393 0.5022 9.7653
HEC-265 CCLE 3.5559 5.1996 2.3219 2.4999
EFE-184 CCLE 3.9617 15.5707 -2.503 23.516
HEC-251 CCLE 3.9736 13.2682 -1.347 19.4457
HEC-59 CCLE 4.5724 11.0304 0.2079 11.357
HEC-6 CCLE 4.7269 6.2311 2.4985 0.4539
TEN CCLE 5.6389 7.599 2.3588 0.3878
KLE GDSC1; GDSC2; CCLE 6.3433 16.4539 -1.186 11.559
EN GDSC1; GDSC2; CCLE 10.045 22.1186 -1.5227 8.3285
Ishikawa (Heraklio) 02 ER- CCLE 3.4066 7.9674 0.8464 10.6426
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 35 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SN12C GDSC1; GDSC2 0.363 6.898 -2.3007 19.0622
769-P GDSC1; GDSC2; CCLE 0.8337 6.2862 -0.6733 20.1684
UO-31 GDSC1; GDSC2 1.288 14.3874 -5.2391 31.2805
NCC021 GDSC1; GDSC2 1.3093 7.4485 -1.7519 16.7343
Caki-2 CCLE 1.369 7.777 -0.8543 24.5361
Caki-1 GDSC1; GDSC2 1.6109 13.072 -4.3141 27.9924
LB1047-RCC GDSC1; GDSC2 1.6764 12.321 -3.8851 24.4432
LB996-RCC GDSC1; GDSC2 1.7843 9.3983 -2.3376 15.9065
SW13 GDSC1; GDSC2 1.7897 10.8063 -3.0363 18.6346
RXF 393L GDSC1; GDSC2 1.8584 10.8019 -2.9788 18.2723
TK-10 GDSC1; GDSC2 1.8861 9.8783 -2.4956 16.3335
CAL-54 GDSC1; GDSC2 2.0855 14.8144 -4.799 23.7476
RCC10RGB GDSC1; GDSC2 2.2918 15.2005 -4.8266 23.4067
A-498 GDSC1; GDSC2 2.3645 12.5152 -3.4313 18.8684
KTCTL-140 GDSC1; GDSC2 2.4635 20.6665 -7.4163 31.1726
KTCTL-195 GDSC1; GDSC2 2.6373 9.9461 -1.9491 12.5808
LB2241-RCC GDSC1; GDSC2 2.6921 7.7239 -0.8216 8.7821
BB65-RCC GDSC1; GDSC2 2.7209 16.6919 -5.2305 25.9643
KMRC-1 GDSC1; GDSC2; CCLE 2.8203 10.2794 -0.7905 16.0426
KTCTL-26A GDSC1; GDSC2 2.8324 18.2166 -5.902 27.377
KTCTL-1M GDSC1; GDSC2 3.0437 19.4919 -6.3711 27.9944
KMRC-2 CCLE 3.153 8.0096 0.6216 12.421
KTCTL-21 GDSC1; GDSC2 3.2025 22.1804 -7.5845 30.052
A-704 GDSC1; GDSC2 3.2664 12.007 -2.4995 13.6767
KTCTL-13 GDSC1; GDSC2 3.3645 13.9618 -3.387 18.8681
SW156 GDSC1; GDSC2 3.6077 11.8514 -2.181 14.9379
ACHN GDSC1; GDSC2; CCLE 3.7875 14.9219 -2.318 19.4626
KMRC-20 GDSC1; GDSC2 4.5414 12.2192 -1.7343 8.5785
HA7-RCC GDSC1; GDSC2 5.1658 16.2066 -3.2121 13.2195
BFTC-909 GDSC1; GDSC2; CCLE 5.5325 18.0835 -2.5494 17.1829
NCC010 GDSC1; GDSC2 5.6155 19.7063 -4.5849 16.9373
VMRC-RCW GDSC1; GDSC2; CCLE 5.6508 7.0606 2.5501 0.0878
VMRC-RCZ GDSC1; GDSC2; CCLE 6.0214 14.344 -0.3948 9.193
OS-RC-2 GDSC1; GDSC2 6.1633 20.3084 -4.5029 15.8967
786-O GDSC1; GDSC2; CCLE 7.634 18.8924 -1.496 10.8985
⏷ Show the Full List of 35 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO201 CCLE -7.0399 -3.4719 -7.0466 81.8385
HCC-56 CCLE -6.1799 0.8858 -6.5304 69.8436
SW403 CCLE -5.8682 5.0423 -7.304 63.4865
CL-11 GDSC1; GDSC2 -5.5048 2.8723 -6.6027 50.9679
COLO205 GDSC1; GDSC2; CCLE -5.2935 0.5706 -5.5221 54.792
LS513 GDSC1; GDSC2; CCLE -4.5421 0.5005 -4.7076 50.3688
NCI-H747 GDSC1; GDSC2; CCLE -4.39 3.0298 -5.0731 49.5037
SW620 GDSC1; GDSC2; CCLE -4.2072 6.5309 -6.0489 48.8149
HT-29 GDSC1; GDSC2; CCLE -4.1354 2.7191 -4.7122 48.0675
HCC2998 GDSC1; GDSC2 -3.9927 3.0643 -5.0325 42.2874
SK-CO-1 GDSC1; GDSC2; CCLE -3.4179 2.6728 -3.9175 43.8009
LS411N GDSC1; GDSC2; CCLE -3.223 4.5141 -4.2578 43.4066
MDST8 GDSC1; GDSC2 -3.1372 4.3997 -4.6296 37.8848
RCM-1 [Human ESC] GDSC1; GDSC2 -2.3549 6.8986 -4.9123 35.654
HT-55 GDSC1; GDSC2 -2.3165 4.2985 -3.7263 32.4032
HCT 116 GDSC1; GDSC2; CCLE -2.1259 2.7742 -2.5341 35.4991
SNU-C1 GDSC1; GDSC2 -1.8545 6.8066 -4.3709 32.6636
SW1463 GDSC1; GDSC2 -1.7417 5.2723 -3.5571 29.89
LoVo GDSC1; GDSC2 -1.7236 9.4257 -5.4822 34.8617
SW480 CCLE -1.7134 7.6333 -3.8704 44.3625
SW626 GDSC1; GDSC2 -1.5357 9.1433 -5.1669 33.62
SW1417 GDSC1; GDSC2; CCLE -1.4919 9.8327 -4.6252 37.8099
KM12 GDSC1; GDSC2 -1.4777 4.3152 -2.8637 26.5956
SNU-407 GDSC1; GDSC2 -1.4124 9.6238 -5.2815 33.5128
NCI-H508 GDSC1; GDSC2 -1.1981 10.0933 -5.3075 36.4149
LS180 GDSC1; GDSC2 -1.1108 7.0144 -3.7399 28.4847
SW1116 GDSC1; GDSC2 -1.0467 7.5559 -3.937 28.9076
SW48 GDSC1; GDSC2; CCLE -0.8787 6.9275 -2.7033 31.7638
SW948 GDSC1; GDSC2 -0.8633 8.4352 -4.1872 29.1188
LS1034 GDSC1; GDSC2 -0.4252 5.2596 -2.2417 20.9373
RKO GDSC1; GDSC2; CCLE -0.3316 6.8051 -2.0875 28.317
GP5d GDSC1; GDSC2 -0.1865 14.137 -6.3823 32.5534
NCI-H716 GDSC1; GDSC2 -0.1779 5.6649 -2.1983 20.0655
DiFi GDSC1; GDSC2 0.0362 7.195 -2.7446 21.7003
SW837 GDSC1; GDSC2 0.1175 7.4391 -2.7904 21.6637
CCK-81 GDSC1; GDSC2; CCLE 0.2164 8.2774 -2.2082 27.1461
COLO 678 GDSC1; GDSC2; CCLE 0.5368 14.222 -4.7761 32.6399
SNU-1040 GDSC2 0.5904 2.3229 -2.5612 0.2908
SNU-61 GDSC1; GDSC2 1.01 10.4375 -3.4983 22.0457
SNU-C2B GDSC1; GDSC2; CCLE 1.3012 10.8391 -2.412 24.9997
T84 GDSC1; GDSC2; CCLE 1.4021 5.5919 0.2134 15.2468
SNU-175 GDSC2 1.4172 11.7303 -3.8031 22.1446
C2BBe1 GDSC1; GDSC2; CCLE 1.4222 16.3248 -5.019 31.0967
CW-2 GDSC1; GDSC2 1.9845 7.1368 -1.0535 9.8689
SNU-C5 GDSC1; GDSC2 2.2999 17.083 -5.7592 25.8133
COLO 320HSR GDSC1; GDSC2 2.6372 4.9646 0.4448 2.023
SNU-C2A CCLE 2.7284 13.7747 -2.6153 26.8323
LS123 GDSC1; GDSC2; CCLE 2.7701 13.0165 -2.201 21.0819
HT115 GDSC1; GDSC2 2.9931 11.1522 -2.2796 13.2914
SNU-283 GDSC2 3.2144 14.1713 -3.6019 21.6479
HCT 15 GDSC1; GDSC2; CCLE 3.419 13.8933 -2.1016 19.4717
SNU-81 GDSC1; GDSC2 4.031 15.1691 -3.4943 16.004
COLO 320 CCLE 5.3492 7.7629 2.1756 1.051
CaR-1 GDSC1; GDSC2 6.0465 17.4596 -3.2314 12.0283
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1; GDSC2 2.7913 9.7276 -1.7281 11.356
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hep-G2 CCLE -3.941 3.9577 -4.8565 56.4052
JHH-5 CCLE -1.9856 2.4733 -2.3067 43.6075
Hep 3B2.1-7 GDSC1; GDSC2; CCLE -1.8862 1.2227 -1.973 32.9377
Hep-G2/C3A GDSC1; GDSC2; CCLE 0.5429 8.2233 -1.863 25.1708
JHH-7 GDSC1; GDSC2; CCLE 0.9915 5.4467 -0.1348 17.6777
SNU-398 GDSC1; GDSC2; CCLE 1.3473 10.7143 -2.3083 24.5718
JHH-2 GDSC1; GDSC2; CCLE 1.3869 8.5937 -1.2334 20.8667
JHH-4 GDSC1; GDSC2; CCLE 1.3946 3.9551 0.9187 12.4788
Huh-7 GDSC1; GDSC2 1.5011 7.3676 -1.5529 13.1364
JHH-1 GDSC1; GDSC2 1.9174 10.7584 -2.9097 17.8862
SNU-182 CCLE 2.4475 9.4913 -0.7168 20.7058
SNU-449 GDSC1; GDSC2; CCLE 3.1049 10.4441 -0.635 14.8796
HuH-1 GDSC1; GDSC2; CCLE 3.4379 10.3655 -0.3245 13.0326
SNU-475 CCLE 3.7767 8.1849 1.0229 8.8936
PLC/PRF/5 CCLE 3.783 10.813 -0.2747 15.33
JHH-6 GDSC1; GDSC2; CCLE 4.5571 14.9434 -1.7289 16.1743
HLE GDSC1; GDSC2; CCLE 4.8873 13.3463 -0.697 11.9701
SNU-423 GDSC1; GDSC2; CCLE 5.5385 14.9184 -0.9991 12.0655
SK-HEP-1 GDSC1; GDSC2; CCLE 6.563 19.4364 -2.4716 15.3926
SNU-387 GDSC1; GDSC2; CCLE 6.7118 20.6582 -2.9596 16.6059
HLF CCLE 6.872 18.2331 -1.6815 15.0403
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 207 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H322 CCLE -6.0755 4.0914 -7.2226 65.1453
NCI-H1666 GDSC1; GDSC2; CCLE -4.3686 3.5877 -5.2095 49.4101
EBC-1 GDSC1; GDSC2; CCLE -4.3159 -0.96 -4.3411 48.9031
NCI-H2122 GDSC1; GDSC2; CCLE -4.2019 0.8911 -4.4005 48.2682
NCI-H2291 GDSC1; GDSC2 -4.1202 4.6731 -5.7785 48.8232
DV-90 CCLE -3.3964 2.0741 -3.7513 54.0595
A-549 GDSC1; GDSC2; CCLE -2.6398 4.761 -3.712 40.183
NCI-H292 GDSC1; GDSC2 -2.4509 7.4747 -5.2726 40.8251
NCI-H1437 GDSC1; GDSC2 -2.2743 15.6798 -9.0372 43.9525
Lu-65 GDSC1; GDSC2 -2.1184 9.8021 -6.0413 37.107
Calu-6 GDSC1; GDSC2; CCLE -2.0936 2.2277 -2.3686 34.9009
NCI-H2795 GDSC1; GDSC2 -1.962 1.1496 -2.2163 25.7062
NCI-H2087 GDSC1; GDSC2; CCLE -1.7847 9.2872 -4.6728 38.793
NCI-H1915 GDSC1; GDSC2; CCLE -1.7423 4.0733 -2.5038 34.0481
NCI-H727 GDSC1; GDSC2; CCLE -1.5196 11.6064 -5.474 39.1562
LCLC-97TM1 GDSC1; GDSC2 -1.4419 8.1102 -4.5818 31.92
NCI-H2135 GDSC1; GDSC2 -1.3987 3.6356 -2.4898 24.8956
NCI-H358 GDSC1; GDSC2; CCLE -0.9708 9.8123 -4.0962 35.2946
NCI-H1993 GDSC1; GDSC2 -0.8177 3.4609 -1.8123 20.2713
HCC44 GDSC1; GDSC2; CCLE -0.7049 6.2228 -2.2213 29.8427
Lu-99 CCLE -0.6776 5.7216 -1.9834 36.2425
Lu-99A GDSC1; GDSC2 -0.5808 4.1984 -1.8999 19.9385
SK-MES-1 GDSC1; GDSC2; CCLE -0.5559 4.8186 -1.4939 27.0406
NCI-H187 GDSC1 -0.544 2.4883 -3.1781 5.1354
NCI-H2009 GDSC1; GDSC2; CCLE -0.5256 9.173 -3.3583 32.3859
NCI-H322M GDSC1; GDSC2 -0.4524 6.5755 -2.8985 23.6279
NCI-H3122 GDSC1; GDSC2 -0.3504 6.4247 -2.729 22.6915
EPLC-272H GDSC1; GDSC2 -0.3132 12.46 -5.6623 31.3804
CAL-12T GDSC1; GDSC2; CCLE -0.1699 8.0044 -2.4647 32.5817
RERF-LC-MS GDSC1; GDSC2; CCLE -0.1574 11.0021 -3.8626 35.826
A-427 GDSC1; GDSC2 -0.1361 5.554 -2.1051 19.5577
EMC-BAC-1 GDSC1; GDSC2 -0.0967 6.4577 -2.5065 24.3296
COR-L105 GDSC1; GDSC2; CCLE 0.0423 9.177 -2.8015 29.3545
NCI-H1299 GDSC1; GDSC2; CCLE 0.1558 9.0068 -2.6105 28.5081
NCI-H460 GDSC1; GDSC2; CCLE 0.2259 13.4331 -4.6769 36.1901
NCI-H1792 GDSC1; GDSC2; CCLE 0.261 7.7888 -1.9365 26.1659
SW1271 GDSC1; GDSC2; CCLE 0.3063 10.5038 -3.1797 29.6552
NCI-H1355 GDSC1; GDSC2; CCLE 0.3163 10.2002 -3.0241 29.221
COLO 668 GDSC1; GDSC2 0.3402 6.0608 -1.9083 17.4498
T3M-10 CCLE 0.4094 8.045 -1.9097 31.711
KNS-62 GDSC1; GDSC2; CCLE 0.4481 9.3304 -2.481 27.3491
RERF-LC-Sq1 GDSC1; GDSC2 0.4936 13.3324 -5.3868 28.7817
NCI-H1734 GDSC2 0.5432 6.0152 -1.7015 20.9167
NCI-H2286 CCLE 0.5932 9.2715 -2.3134 32.2744
COLO 677 CCLE 0.6016 9.7003 -2.5114 32.798
HOP-92 GDSC1; GDSC2 0.6101 7.242 -2.2504 18.2322
LC-2/ad GDSC1; GDSC2 0.9192 5.4279 -1.0756 14.34
NCI-H1623 GDSC1; GDSC2 0.9422 8.6227 -2.6495 19.0558
NCI-H290 GDSC1; GDSC2 0.9562 22.1294 -9.3881 36.9449
NCI-H1304 GDSC1 1.1575 2.5879 -2.4538 0.0634
NCI-H2373 GDSC1; GDSC2 1.2029 13.2357 -4.7344 25.4554
EMC-BAC-2 GDSC1; GDSC2 1.2277 12.9411 -4.5663 24.9233
NCI-H1944 GDSC1; GDSC2; CCLE 1.3381 13.7095 -3.7958 28.6542
NCI-H2347 GDSC1; GDSC2 1.3506 12.7437 -4.3651 24.0589
NCI-H2405 GDSC1; GDSC2 1.3965 15.0278 -5.469 26.9579
NCI-H2227 GDSC1; GDSC2 1.4367 5.6522 -0.7484 9.5702
NCI-H1573 GDSC1; GDSC2; CCLE 1.4627 8.5974 -1.1643 20.4341
HCC15 GDSC1; GDSC2; CCLE 1.4647 14.8303 -4.2387 29.3871
HCC4006 CCLE 1.4979 6.9419 -0.3295 21.8107
NCI-H513 GDSC1; GDSC2 1.5145 5.8642 -0.7908 9.6039
NCI-H2591 GDSC1; GDSC2 1.5598 8.0704 -1.8562 14.3497
NCI-H1975 GDSC1; GDSC2; CCLE 1.5936 11.4617 -2.4533 24.4359
Calu-3 GDSC1; GDSC2; CCLE 1.6804 5.3038 0.6233 12.9034
LK-2 GDSC1; GDSC2 1.6905 6.3406 -0.8873 9.6888
Sq-1 CCLE 1.7788 5.2473 0.7468 15.6126
NCI-H2444 GDSC1; GDSC2; CCLE 1.8977 15.2307 -4.0566 30.6391
HOP-62 GDSC1; GDSC2 1.9598 14.2163 -4.6017 23.4442
Calu-1 CCLE 1.977 16.5333 -4.637 33.5668
NCI-H23 GDSC1; GDSC2; CCLE 2.0062 9.3306 -1.0274 18.6726
NCI-H2228 GDSC1; GDSC2; CCLE 2.0082 7.2713 -0.0097 14.7024
PC-14 GDSC1; GDSC2; CCLE 2.0156 9.3471 -1.0271 18.6502
SBC-5 GDSC1; GDSC2; CCLE 2.02 6.8504 0.2075 13.7934
NCI-H1755 GDSC1; GDSC2 2.0353 6.9107 -0.9025 9.0753
NCI-H1869 GDSC1; GDSC2; CCLE 2.0917 12.6806 -2.6167 23.8024
NCI-H2141 GDSC1; GDSC2 2.1341 4.2287 0.4768 2.5492
NCI-H2110 GDSC1; GDSC2 2.1599 11.9248 -3.2984 21.2164
NCI-H446 GDSC1; GDSC2 2.2055 5.9557 -0.3062 6.0012
COR-L88 GDSC1; GDSC2 2.2922 5.1481 0.1446 3.7951
SBC-3 GDSC1; GDSC2 2.2925 7.435 -0.9682 8.8932
NCI-H1838 GDSC1; GDSC2 2.3008 5.9307 -0.2264 5.4701
NCI-H2369 GDSC1; GDSC2 2.3492 5.0554 0.2262 3.343
NCI-H64 GDSC1; GDSC2 2.3525 4.525 0.476 2.2477
BEN GDSC1; GDSC2 2.3611 13.3539 -3.8515 22.6927
NCI-H2810 GDSC1; GDSC2 2.3884 9.9653 -2.1464 13.8845
EKVX GDSC1; GDSC2 2.4186 14.6489 -4.4511 22.0659
NCI-H250 GDSC2 2.435 4.431 0.5678 1.7604
NCI-H2029 GDSC1; GDSC2 2.4454 5.5827 0.0393 4.0318
NCI-H345 GDSC1; GDSC2 2.4501 3.3909 1.01 0.2233
NCI-H720 GDSC1; GDSC2 2.4743 3.7749 0.8709 0.5942
NCI-H1963 GDSC2 2.4939 6.2006 -0.2233 5.139
NCI-H1876 GDSC1; GDSC2 2.5182 5.6212 0.0688 3.7913
NCI-H2171 GDSC2 2.5323 4.311 0.6748 1.6434
NCI-H2804 GDSC1; GDSC2 2.5449 6.5183 -0.3412 5.5908
NCI-H526 GDSC1; GDSC2 2.5808 4.9621 0.4131 2.2213
Lu-139 GDSC1; GDSC2 2.5978 4.949 0.429 2.1347
SW900 CCLE 2.6147 5.2157 1.5567 8.8347
Lu-165 GDSC1; GDSC2 2.6175 5.0048 0.4154 2.1672
COR-L32 GDSC2 2.6362 7.3192 -0.6646 6.9066
HARA [Human squamous cell lung carcinoma] GDSC1; GDSC2; CCLE 2.653 9.2935 -0.4404 15.0313
NCI-H196 GDSC1; GDSC2 2.6632 4.6299 0.6067 1.3588
COR-L311 GDSC2 2.6697 5.8169 0.0738 3.5517
COR-L279 GDSC1; GDSC2 2.6734 5.0458 0.4292 2.0441
SK-LU-1 GDSC1; GDSC2; CCLE 2.6755 17.5624 -4.5534 27.5416
NCI-H2196 GDSC2 2.7628 6.9996 -0.4245 7.4509
PaCa-3 GDSC1; GDSC2 2.7639 8.2021 -1.0031 8.2163
NCI-H510A GDSC1; GDSC2 2.7784 5.5541 0.2612 3.0608
COR-L303 GDSC2 2.8007 4.674 0.6588 1.3908
NCI-H1435 GDSC1; GDSC2 2.8049 6.8159 -0.3092 5.0418
LXF 289 GDSC1; GDSC2 2.8165 10.0566 -1.8711 11.9202
NCI-H3255 GDSC1; GDSC2; CCLE 2.839 8.8872 -0.0788 13.2108
NCI-H1581 GDSC1; GDSC2; CCLE 2.8846 13.1718 -2.1824 20.7883
Lu-135 GDSC1; GDSC2 2.9393 5.8867 0.2049 2.6446
COR-L95 GDSC1; GDSC2 2.9539 9.5392 -1.5188 10.1646
NCI-H2461 GDSC1; GDSC2 2.9563 18.4477 -5.9199 24.9498
SBC-1 GDSC1; GDSC2 2.9751 4.6912 0.7349 0.7844
Ms-1 GDSC1; GDSC2 2.9833 5.1965 0.5313 1.3326
NCI-H2172 GDSC1; GDSC2; CCLE 2.9859 6.6846 1.146 9.0238
NCI-H847 GDSC1; GDSC2 2.9908 4.6989 0.7389 0.6466
NCI-H835 GDSC1; GDSC2 2.9983 8.857 -1.1565 8.504
NCI-H2023 GDSC1; GDSC2; CCLE 3.0201 12.0233 -1.4949 18.2141
NCI-H1048 GDSC1; GDSC2; CCLE 3.0461 5.9016 1.5875 5.8666
LC-1/sq-SF CCLE 3.0478 13.0317 -1.9761 23.9752
DMS 53 GDSC1; GDSC2 3.064 11.2659 -2.2835 13.1789
NCI-H596 GDSC1; GDSC2 3.0848 9.692 -1.5005 9.8608
NCI-H146 GDSC1; GDSC2 3.1054 4.8641 0.7251 0.7233
NCI-H69 GDSC1; GDSC2 3.1198 5.4895 0.4771 1.4038
HCC33 GDSC2 3.1235 4.6071 0.8309 0.4545
Lu-134-A GDSC1; GDSC2 3.1457 6.0205 0.262 2.5605
UMC-11 GDSC1; GDSC2 3.1474 6.1912 0.1877 2.4731
NCI-H524 GDSC1; GDSC2 3.1511 6.9214 -0.1401 3.8198
NCI-H209 GDSC1; GDSC2 3.1702 6.6406 -0.0007 3.2118
NCI-H1648 GDSC1; GDSC2; CCLE 3.1826 9.2674 0.0172 12.1489
LB647-SCLC GDSC1; GDSC2 3.2366 13.8136 -3.4089 19.2151
NCI-H1688 GDSC1; GDSC2 3.2396 10.2311 -1.6534 10.2537
COR-L321 GDSC1; GDSC2 3.258 4.8373 0.7998 0.4155
NCI-H82 GDSC1; GDSC2 3.2764 5.2806 0.6377 0.7615
NCI-H1105 GDSC1; GDSC2 3.3262 5.2492 0.6721 0.7456
NCI-H1703 GDSC1; GDSC2; CCLE 3.3755 8.7226 0.4453 10.0359
NCI-H1770 GDSC1; GDSC2 3.3915 4.7847 0.8704 0.2102
NCI-H1836 GDSC1; GDSC2 3.4146 4.9674 0.814 0.315
NCI-H2342 GDSC1; GDSC2 3.4825 9.1492 -0.9708 6.9303
DMS 79 GDSC1; GDSC2 3.51 5.4042 0.691 0.4935
DMS 114 GDSC1; GDSC2; CCLE 3.5324 6.3614 1.7397 4.3675
CPC-N GDSC1; GDSC2 3.5679 6.196 0.4047 1.281
NCI-H520 GDSC1; GDSC2; CCLE 3.729 6.7138 1.71 4.1793
SW1573 GDSC1; GDSC2; CCLE 3.746 11.0431 -0.418 12.8348
NCI-H1436 GDSC1; GDSC2 3.7722 5.2176 0.8581 0.1385
NCI-H226 GDSC1; GDSC2; CCLE 3.7903 13.5263 -1.6199 17.1668
DMS 273 GDSC1; GDSC2 3.8247 11.0014 -1.6245 9.188
NCI-H2081 GDSC1; GDSC2 3.886 5.5253 0.7929 0.2086
NCI-H2170 GDSC1; GDSC2; CCLE 3.9057 5.8192 2.2546 1.7612
GLC-82 CCLE 3.9261 8.7122 0.8742 9.3512
NCI-H838 GDSC1; GDSC2 3.9415 22.6838 -7.2621 28.1121
NCI-H1563 GDSC1; GDSC2; CCLE 3.9498 11.2153 -0.3454 12.1907
IST-SL1 GDSC1; GDSC2 3.9592 5.7588 0.738 0.2834
NCI-H2731 GDSC1; GDSC2 3.9657 11.5801 -1.8064 9.7212
NCI-H748 GDSC2 4.0612 6.121 0.6472 0.4932
IST-SL2 GDSC1; GDSC2 4.0623 13.6509 -2.7351 13.2223
ABC-1 GDSC1; GDSC2 4.0934 13.3613 -2.5738 12.5605
NCI-H1693 GDSC1; GDSC2; CCLE 4.0955 15.9832 -2.6028 19.773
Hs 229.T CCLE 4.1028 10.4249 0.1618 12.551
HCC2935 CCLE 4.1439 12.791 -0.9779 17.5845
LC-1/sq GDSC1; GDSC2 4.1446 16.5543 -4.0892 17.7705
NCI-H1373 CCLE 4.1612 12.2477 -0.6954 16.3543
NCI-H1568 GDSC1; GDSC2; CCLE 4.2139 14.9454 -1.9937 17.6503
NCI-H441 GDSC1; GDSC2; CCLE 4.224 16.176 -2.5978 19.5275
NCI-H2030 GDSC1; GDSC2; CCLE 4.2383 19.7789 -4.3811 27.909
NCI-H2803 GDSC2 4.2596 12.1627 -1.8892 9.6105
NCI-H650 GDSC1; GDSC2; CCLE 4.2712 12.2081 -0.5924 12.5878
NCI-H647 GDSC1; GDSC2; CCLE 4.2875 11.8445 -0.4005 13.435
ChaGo-K-1 GDSC1; GDSC2 4.2952 6.4625 0.6143 0.4174
NCI-H1781 GDSC1; GDSC2 4.4496 13.9121 -2.596 12.0792
NCI-H661 GDSC1; GDSC2; CCLE 4.4892 8.0511 1.5814 3.6371
COLO 699 CCLE 4.4947 11.2916 0.0243 12.3869
COR-L23 GDSC1; GDSC2; CCLE 4.5018 12.5681 -0.5975 12.221
NCI-H1184 CCLE 4.6046 6.7907 2.2159 1.553
NCI-H2066 GDSC1; GDSC2 4.6455 17.4588 -4.1725 17.2014
NCI-H810 GDSC1; GDSC2; CCLE 4.6571 6.1404 2.5037 0.3717
HCC827 GDSC1; GDSC2; CCLE 4.6683 11.7345 -0.067 9.9151
NCI-H740 GDSC2 4.6751 6.9196 0.5949 0.3777
NCI-H1339 CCLE 4.6962 14.9962 -1.6498 19.0037
NCI-H1793 GDSC1; GDSC2; CCLE 4.7055 14.7297 -1.5113 15.1832
HCC366 GDSC1; GDSC2 4.7735 21.3543 -5.9835 21.9843
NCI-H1155 GDSC1; GDSC2; CCLE 4.7836 13.6685 -0.9307 12.9962
NCI-H2818 GDSC1; GDSC2 4.8143 17.2234 -3.94 16.196
NCI-H522 GDSC1; GDSC2; CCLE 4.8319 11.4537 0.1854 8.6779
LUDLU-1 CCLE 4.8369 17.8274 -2.9441 22.9735
RERF-LC-A1 CCLE 4.8564 15.4143 -1.7361 18.9842
NCI-H2595 GDSC1; GDSC2 4.9244 13.6087 -2.1415 9.6382
NCI-H841 GDSC1; GDSC2 5.0641 15.3346 -2.8649 12.1401
NCI-H1651 GDSC1; GDSC2; CCLE 5.082 11.1591 0.4979 7.095
MOR/CPR CCLE 5.2177 13.0217 -0.3046 12.4733
NCI-H2085 GDSC1; GDSC2; CCLE 5.3049 13.9073 -0.6726 11.2347
NCI-H1650 GDSC1; GDSC2; CCLE 5.3652 9.8164 1.3029 3.6646
NCI-H1341 GDSC1; GDSC2; CCLE 5.4033 13.151 -0.2392 9.4746
NCI-H2869 GDSC1; GDSC2 5.4351 14.4142 -2.1965 9.1485
LCLC-103H GDSC1; GDSC2; CCLE 5.5802 11.3463 0.731 5.5511
NCI-H1694 GDSC1; GDSC2; CCLE 5.6107 7.5416 2.3686 0.2936
NCI-H2722 GDSC1; GDSC2 5.7773 17.6272 -3.4838 13.2523
NCI-H1092 GDSC1; GDSC2; CCLE 5.8388 7.3174 2.5286 0.0657
RERF-LC-KJ GDSC1; GDSC2 6.885 20.2669 -4.0129 13.431
VMRC-LCD GDSC1; GDSC2; CCLE 6.9213 18.5787 -1.8135 12.8458
LOU-NH91 GDSC1; GDSC2; CCLE 7.3461 21.3063 -2.8333 15.3588
NCI-H211 GDSC1; GDSC2; CCLE 7.3509 20.3181 -2.3565 13.9523
SHP-77 GDSC1; GDSC2; CCLE 7.5309 20.1253 -2.1449 13.0719
HCC78 GDSC1; GDSC2; CCLE 8.5511 23.006 -2.8414 13.8235
IA-LM GDSC1; GDSC2; CCLE 8.5525 21.3804 -2.0779 11.5996
⏷ Show the Full List of 207 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1; GDSC2 2.9036 5.2234 0.4783 1.6032
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-30 CCLE -3.0346 5.712 -4.4839 51.1391
TE-15 GDSC1; GDSC2; CCLE -0.5409 8.2355 -2.9421 31.3855
OE21 GDSC1; GDSC2; CCLE -0.3058 6.5405 -1.945 27.7912
TE-4 GDSC1; GDSC2 0.6689 3.3767 -0.29 9.2075
OE33 GDSC1; GDSC2; CCLE 0.7889 3.9471 0.2753 16.6423
KYSE-70 GDSC1; GDSC2; CCLE 0.8429 7.4586 -1.2093 22.1334
EC-GI-10 GDSC1; GDSC2 0.9825 11.3294 -3.9675 23.6694
TE-11 GDSC1; GDSC2; CCLE 1.2061 8.6886 -1.4495 24.998
KYSE-520 GDSC1; GDSC2; CCLE 1.2399 11.6344 -2.8594 26.4545
KYSE-140 GDSC1; GDSC2; CCLE 1.6406 6.1111 0.2048 14.6935
OE19 GDSC1; GDSC2 2.3425 6.1928 -0.3243 5.8488
TE-8 GDSC1; GDSC2 2.4138 11.9753 -3.1244 17.6684
TE-10 GDSC1; GDSC2 2.4389 9.5443 -1.8995 14.6855
KYSE-150 GDSC1; GDSC2; CCLE 2.5251 9.753 -0.78 16.6136
KYSE-450 GDSC1; GDSC2; CCLE 2.8587 9.289 -0.263 13.91
KYSE-270 GDSC1; GDSC2 3.1614 10.2505 -1.7177 10.6601
TE-1 GDSC1; GDSC2; CCLE 3.6966 13.1376 -1.5006 16.9284
TE-6 GDSC1; GDSC2 4.205 17.2902 -4.4055 18.6458
TE-9 GDSC1; GDSC2; CCLE 4.4135 9.3276 0.9227 6.3606
KYSE-410 GDSC1; GDSC2; CCLE 4.5911 14.8544 -1.6591 15.8809
KYSE-180 GDSC1; GDSC2; CCLE 4.6478 10.1527 0.6863 6.9663
T.T GDSC1; GDSC2 4.8112 15.9759 -3.3406 14.2058
KYSE-510 GDSC1; GDSC2; CCLE 4.9421 6.9016 2.3327 0.6396
COLO 680N GDSC1; GDSC2 5.8413 16.8329 -3.0684 11.7508
TE-5 GDSC1; GDSC2; CCLE 5.8741 14.2149 -0.431 9.5258
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OV-90 GDSC1; GDSC2; CCLE -2.8992 5.0058 -4.0789 41.8226
OVCAR-5 GDSC1; GDSC2 -1.5696 11.562 -6.3703 36.0844
ES-2 GDSC1; GDSC2; CCLE -1.1389 6.636 -2.848 32.9664
Caov-4 GDSC1; GDSC2 -1.0908 8.9622 -4.6572 31.0731
HEY A8 CCLE -0.539 8.0513 -2.8563 37.8194
IGROV-1 GDSC1; GDSC2; CCLE -0.5353 11.7556 -4.5863 35.0022
A2780 GDSC1; GDSC2; CCLE -0.3873 5.5778 -1.6194 26.9612
MCAS CCLE 0.276 5.5224 -0.9039 28.5973
TYK-nu GDSC1; GDSC2; CCLE 1.1812 12.6726 -3.4247 28.1052
COV504 CCLE 1.8226 12.4989 -2.7631 29.7062
OV56 GDSC1; GDSC2 1.9974 5.0901 -0.0332 5.1024
FU-OV-1 GDSC1; GDSC2; CCLE 2.2011 13.1581 -2.7593 23.9827
RMG-I GDSC1; GDSC2 2.965 17.0056 -5.1962 23.1108
OVISE GDSC1; GDSC2 3.4841 13.5457 -3.095 15.5428
TOV-21G GDSC1; GDSC2; CCLE 3.6029 12.6906 -1.3525 16.5824
Kuramochi GDSC1; GDSC2; CCLE 3.7234 12.9618 -1.3916 16.4963
EFO-21 GDSC1; GDSC2; CCLE 3.768 12.4488 -1.1006 15.3699
ONCO-DG-1 CCLE 3.8728 10.1986 0.0996 13.3559
Caov-3 GDSC2 3.9137 13.6257 -2.8267 17.1039
OC 315 CCLE 4.0159 6.0374 2.2212 2.262
OVCAR-8 GDSC1; GDSC2; CCLE 4.0379 11.4277 -0.3832 12.1846
OC 316 CCLE 4.099 8.0781 1.3083 6.7527
OVMANA CCLE 4.2826 9.3797 0.8056 8.9777
COV318 CCLE 4.3969 5.5014 2.6362 0.2601
OVSAHO CCLE 4.5862 15.2408 -1.854 19.9741
TOV-112D GDSC1; GDSC2; CCLE 4.6208 13.0375 -0.7403 12.5608
DOV13 GDSC1; GDSC2; CCLE 4.6966 7.4393 1.984 1.9069
JHOS-2 GDSC1; GDSC2; CCLE 5.2322 16.4639 -1.9743 17.6514
OVK18 GDSC1; GDSC2 5.4257 20.7827 -5.2369 19.0563
OVCAR-3 GDSC1; GDSC2; CCLE 5.8594 15.5737 -1.0929 11.9231
JHOS-4 GDSC1; GDSC2; CCLE 6.0396 31.7228 -8.9135 31.0725
EFO-27 GDSC1; GDSC2; CCLE 6.1565 19.9662 -3.0179 17.5886
OAW28 GDSC1; GDSC2 6.3637 17.0094 -2.8245 10.2104
SK-OV-3 GDSC1; GDSC2; CCLE 6.5198 21.4454 -3.4793 18.3174
OAW42 GDSC1; GDSC2 7.0746 21.2392 -4.3478 14.1928
OVCAR-4 GDSC1; GDSC2; CCLE 7.2756 22.5404 -3.4772 17.2344
OC 314 GDSC1; GDSC2; CCLE 7.8604 19.3624 -1.5723 10.8647
OVKATE GDSC1; GDSC2 8.5771 24.2645 -4.8146 13.6577
OVTOKO GDSC1; GDSC2; CCLE 9.0274 22.3202 -2.2184 11.4656
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 38 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PK-45H CCLE -4.5468 2.8878 -5.2057 60.2023
PSN1 GDSC1; GDSC2; CCLE -2.1855 3.2598 -2.7321 36.2607
Panc 02.03 GDSC1; GDSC2; CCLE -2.1198 5.9389 -3.5951 38.0149
HuP-T4 GDSC1; GDSC2; CCLE -2.1037 5.32 -3.3394 37.4208
AsPC-1 GDSC1; GDSC2; CCLE -1.9859 5.28 -3.1982 36.6816
MIA PaCa-2 GDSC1; GDSC2; CCLE -1.4527 8.5089 -3.9873 36.5477
HPAF-II GDSC1; GDSC2; CCLE -1.3417 4.9192 -2.3725 32.3139
Hs 766T GDSC1; GDSC2; CCLE -1.1237 14.1969 -6.3206 39.1532
KP-2 GDSC1; GDSC2; CCLE -1.1064 8.5381 -3.6491 34.776
Capan-2 GDSC1; GDSC2; CCLE -1.0919 10.517 -4.5436 36.4834
QGP-1 GDSC1; GDSC2; CCLE -0.9721 9.3035 -3.8626 34.8244
KCI-MOH1 CCLE -0.9362 4.258 -1.6948 36.5584
PK-59 CCLE -0.8647 4.2993 -1.6323 36.0314
Panc 04.03 GDSC1; GDSC2; CCLE -0.6964 7.5543 -2.7921 31.4485
PL4 GDSC1; GDSC2 -0.6801 8.1346 -3.869 27.6323
HPAC GDSC1; GDSC2; CCLE -0.3847 6.7393 -2.113 28.552
SUIT-2 GDSC1; GDSC2; CCLE -0.3627 4.1918 -1.0526 24.9151
PL45 CCLE -0.3094 8.065 -2.632 36.4086
PK-1 CCLE -0.1203 7.5693 -2.2161 34.6023
Panc 10.05 GDSC1; GDSC2; CCLE 0.0854 7.3994 -1.9321 26.6349
Panc 03.27 GDSC1; GDSC2; CCLE 0.4304 10.8241 -3.2163 29.4266
BxPC-3 GDSC1; GDSC2; CCLE 0.4593 6.3352 -1.0728 22.6494
HuP-T3 GDSC1; GDSC2; CCLE 0.5607 10.1523 -2.7682 27.8835
SW1990 GDSC1; GDSC2; CCLE 0.6301 7.8378 -1.596 24.046
MZ-PC-1 GDSC1; GDSC2 0.8047 11.3238 -4.1163 27.4456
DAN-G GDSC1; GDSC2 1.0387 9.3881 -2.9495 19.9905
Capan-1 GDSC1; GDSC2 1.0701 11.3363 -3.8967 23.2386
KP-4 GDSC1; GDSC2; CCLE 1.887 9.0659 -1.004 18.8548
KP-3 GDSC1; GDSC2; CCLE 2.1547 8.132 -0.3005 15.542
PaTu 8902 GDSC1; GDSC2; CCLE 2.5645 12.2677 -2.0016 20.8663
YAPC GDSC1; GDSC2 2.6422 6.5412 -0.2864 5.1889
CFPAC-1 GDSC1; GDSC2 2.9982 13.1799 -3.2746 17.079
L3.3 CCLE 3.3723 11.795 -1.0912 19.8573
KP-1NL CCLE 3.373 14.3641 -2.3743 24.4839
SU.86.86 GDSC2; CCLE 3.4024 12.9694 -1.6535 18.0132
KP-1N GDSC1; GDSC2; CCLE 3.4874 8.5396 0.6252 9.0891
PaTu 8988t GDSC1; GDSC2 3.5553 20.882 -6.6649 25.565
Panc 08.13 GDSC1; GDSC2 4.0741 12.4393 -2.1442 10.9156
⏷ Show the Full List of 38 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H GDSC1; GDSC2; CCLE 0.7338 7.0239 -1.113 22.0668
NCI-H28 GDSC1; GDSC2; CCLE 2.3427 8.1541 -0.1434 14.5037
IST-Mes2 CCLE 2.5127 7.8658 0.15 16.486
MPP 89 GDSC1; GDSC2; CCLE 3.0213 7.3184 0.8585 8.9812
NCI-H2452 GDSC1; GDSC2; CCLE 3.5088 12.3024 -1.2343 16.3371
NCI-H2052 GDSC1; GDSC2; CCLE 5.6936 12.4774 0.2741 7.1366
IST-Mes1 GDSC1; GDSC2; CCLE 6.3897 15.7262 -0.8082 10.1817
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU145 GDSC1; GDSC2; CCLE 2.9868 6.334 1.322 7.0995
NCI-H660 GDSC2 3.0499 4.2883 0.9183 0.2577
VCaP GDSC1; GDSC2 3.2795 9.9593 -1.4942 9.5074
LNCaP clone FGC GDSC1; GDSC2 3.664 6.6985 0.2435 1.7505
22Rv1 GDSC1; GDSC2; CCLE 4.4958 18.8535 -3.7173 22.1719
PC-3 GDSC1; GDSC2; CCLE 5.5624 8.0195 2.1697 0.7198
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1; GDSC2; CCLE 3.395 11.404 -0.8775 15.2415
Cancer Drug Sensitivity Data Curated from 74 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
G-mel GDSC1; GDSC2 -8.5033 -4.5923 -8.5176 72.2095
SK-MEL-28 GDSC1; GDSC2 -8.2085 3.379 -9.7054 69.1339
CP50-MEL-B GDSC1; GDSC2 -8.1744 2.5417 -9.3988 67.0748
WM88 CCLE -8.0594 -0.9617 -8.2634 79.037
Malme-3M CCLE -7.9916 -4.3923 -7.9955 87.1877
451Lu GDSC1; GDSC2 -7.4386 -0.8942 -7.7376 69.4465
M14 GDSC1; GDSC2 -7.4275 -1.2397 -8.147 53.1615
WM983B CCLE -7.1754 -3.0691 -7.1915 81.4304
IPC-298 GDSC1; GDSC2; CCLE -6.818 -0.8782 -6.9574 70.48
UACC-62 GDSC1; GDSC2; CCLE -6.6231 2.7616 -7.4378 59.9698
IGR-37 GDSC1; GDSC2; CCLE -6.61 0.3694 -6.9043 61.6145
CP66-MEL GDSC1; GDSC2 -6.4427 9.1982 -10.1014 53.6685
A-375 GDSC1; GDSC2; CCLE -6.3482 -0.8907 -6.4609 61.2025
WT2-iPS GDSC1; GDSC2; CCLE -6.3271 -3.4891 -6.329 62.2235
SH-4 GDSC1; GDSC2 -6.3099 -0.5998 -6.5719 56.3467
LB2518-MEL GDSC1; GDSC2 -6.1076 0.6196 -6.6057 61.2244
COLO 679 GDSC1; GDSC2; CCLE -5.7605 1.4616 -6.1888 56.9205
Mel Ho GDSC1; GDSC2; CCLE -5.7538 -0.778 -5.8467 65.2127
Hs 938.T GDSC1; GDSC2; CCLE -5.3021 25.2128 -15.6064 53.1819
WM266-4 CCLE -5.0184 -1.7877 -5.0309 67.888
HT-144 GDSC1; GDSC2; CCLE -4.9335 2.9343 -5.6402 52.3486
SK-MEL-1 GDSC1; GDSC2 -4.9285 0.4599 -5.2848 47.4126
MZ-MEL-7 GDSC1; GDSC2 -4.8722 3.5311 -6.148 52.96
WM35 GDSC1; GDSC2 -4.7346 2.3301 -5.5882 46.5797
RVH-421 GDSC1; GDSC2; CCLE -4.6734 5.9608 -6.3353 55.2723
MZ-MEL-2 GDSC1; GDSC2 -4.47 3.0924 -5.5578 50.7824
COLO 783 GDSC1; GDSC2 -4.1756 3.8452 -5.5158 49.0615
SK-MEL-30 GDSC2; CCLE -4.0796 4.9527 -5.3356 56.5513
UACC-257 GDSC1; GDSC2; CCLE -4.0384 3.1964 -4.7357 47.5881
G-361 GDSC1; GDSC2; CCLE -3.9873 1.8116 -4.3369 47.0595
MDA-MB-435S CCLE -3.8512 7.1037 -5.8931 54.6331
Hs 936.T CCLE -3.7761 2.8759 -4.3614 56.0821
HMV-II GDSC2 -3.5832 3.6776 -4.8185 40.1029
WM1799 CCLE -3.463 8.6883 -6.1363 52.6546
GAK GDSC1; GDSC2 -3.1956 1.2562 -3.5904 35.3576
MMAc-SF GDSC2 -3.0941 12.4285 -8.2355 48.0755
K029AX CCLE -2.8136 9.366 -5.7573 49.9655
COLO 829 GDSC1; GDSC2 -2.6092 8.3596 -5.8396 38.3111
SK-MEL-5 GDSC1; GDSC2; CCLE -2.5969 7.7081 -4.82 41.7121
A101D GDSC1; GDSC2 -2.4207 10.1489 -6.4984 38.7539
WM278 GDSC1; GDSC2 -2.1994 21.0117 -11.5922 42.8925
LOX-IMVI GDSC1; GDSC2; CCLE -1.9271 6.3257 -3.5456 37.2334
SK-MEL-2 GDSC1; GDSC2; CCLE -1.7908 3.9377 -2.5115 34.2388
Hs 944.T CCLE -1.6719 5.7365 -3.0398 43.1404
SK-MEL-24 GDSC1; GDSC2; CCLE -1.19 10.5593 -4.6603 36.9703
COLO 800 GDSC1; GDSC2 -1.0385 1.7575 -1.3849 22.4719
LB373-MEL-D GDSC1; GDSC2 -0.9993 30.9136 -15.4502 44.347
COLO 792 GDSC1; GDSC2 -0.8224 13.2618 -6.5174 34.3669
COLO 741 CCLE -0.3282 6.541 -1.9682 34.7235
WM793 GDSC1; GDSC2; CCLE -0.3004 7.0965 -2.185 28.5279
WM115 GDSC1; GDSC2; CCLE -0.2584 9.1437 -3.0808 30.9344
SK-MEL-3 GDSC1; GDSC2 -0.172 17.2636 -7.9257 37.6515
Hs 695T CCLE 0.016 7.5423 -2.0669 33.6521
A2058 GDSC1; GDSC2; CCLE 0.1738 8.7139 -2.4549 28.0067
A-431 GDSC1; GDSC2 0.2648 6.6272 -2.2561 22.0917
Hs 852.T CCLE 0.2758 8.9558 -2.4694 33.818
WM1552C GDSC1; GDSC2 0.2826 10.1224 -3.9719 25.3805
IGR-1 GDSC1; GDSC2 0.885 9.1033 -2.9386 20.3122
IST-MEL1 GDSC1; GDSC2 1.0137 9.4624 -3.0079 20.2691
SF8657 CCLE 1.1427 7.9529 -1.1547 26.4952
Mel JuSo GDSC1; GDSC2 1.3475 12.1074 -4.0495 23.0956
DJM-1 GDSC1; GDSC2 1.6252 7.5904 -1.5633 14.9902
MeWo GDSC1; GDSC2; CCLE 1.8163 12.4314 -2.7352 24.7625
Hs 895.T CCLE 1.9285 4.5777 1.2049 12.7672
HMCB CCLE 2.2725 7.4174 0.1592 17.1153
Hs 940.T GDSC1; GDSC2 2.3374 4.2216 0.6054 2.0222
Hs 294T CCLE 2.3953 13.5438 -2.7839 28.1922
RPMI-7951 GDSC1; GDSC2; CCLE 2.9425 12.9597 -2.0278 20.1724
IGR-39 CCLE 2.9506 4.0508 2.4329 3.1983
VMRC-MELG GDSC2 3.095 4.6653 0.7973 0.5761
CHL-1 GDSC1; GDSC2; CCLE 3.4922 10.0903 -0.1438 12.2153
A-388 GDSC1; GDSC2 3.4998 14.669 -3.635 19.477
SK-MEL-31 GDSC1; GDSC2; CCLE 6.9171 35.6313 -10.1772 31.3922
EquiPSC Line K2 GDSC1; GDSC2 -7.1172 3.5291 -8.5729 62.6483
⏷ Show the Full List of 74 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1; GDSC2 0.7546 13.5922 -5.2921 27.9435
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hs 633.T GDSC1; GDSC2 -1.7597 4.2259 -3.116 28.4473
SW872 GDSC1; GDSC2 -0.2896 5.2324 -2.0977 19.95
TE 617.T CCLE -0.1877 7.9156 -2.4418 35.4656
RD GDSC1; GDSC2; CCLE 0.6136 9.64 -2.471 26.8878
RKN GDSC1; GDSC2; CCLE 0.6772 10.8632 -3.0027 28.2322
HT-1080 GDSC1; GDSC2; CCLE 1.0327 9.4967 -2.0048 24.3789
KYM-1 GDSC1; GDSC2; CCLE 1.2641 3.4653 0.9608 12.6894
SK-LMS-1 GDSC1; GDSC2; CCLE 1.3896 8.3454 -1.1101 20.4115
G-401 GDSC1; GDSC2; CCLE 1.529 10.5447 -2.0589 23.3538
SW684 GDSC1; GDSC2 1.5985 6.2255 -0.9033 9.9536
MFH-ino GDSC1; GDSC2 2.3159 15.7909 -5.1018 24.1127
GCT GDSC1; GDSC2; CCLE 2.4214 12.7435 -2.3619 22.3165
A-204 GDSC1; GDSC2; CCLE 2.6091 8.8732 -0.2684 14.4411
STS-0421 GDSC1; GDSC2 2.6449 15.2103 -4.5529 24.2538
TE 441.T GDSC2 3.0345 4.3543 0.8885 0.3386
SW982 GDSC1; GDSC2 3.2834 17.8655 -5.3774 23.0005
EW-8 GDSC1; GDSC2 3.4017 5.1098 0.7568 0.3897
Rh41 GDSC1; GDSC2 3.4442 9.7583 -1.2856 8.3459
Hs 729.T CCLE 3.67 5.8499 2.0874 3.5058
G-402 GDSC1; GDSC2; CCLE 3.7531 11.7639 -0.7713 14.1759
Rh30 GDSC1; GDSC2; CCLE 4.3766 7.4029 1.8126 2.8844
SK-UT-1 GDSC2 4.7417 12.7846 -1.8719 8.8438
VA-ES-BJ GDSC1; GDSC2 5.5839 15.7989 -2.7478 10.9747
Rh18 GDSC1; GDSC2 6.076 21.6949 -5.2264 19.748
MES-SA GDSC1; GDSC2; CCLE 6.8959 15.2558 -0.2657 7.6239
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OCUM-1 GDSC1; GDSC2; CCLE -7.1903 -1.8233 -7.2645 66.1824
AGS GDSC1; GDSC2 -4.9912 1.7452 -5.6879 48.0255
TMK-1 GDSC1; GDSC2 -4.1674 13.4744 -9.7709 49.4867
NUGC-4 GDSC1; GDSC2; CCLE -2.1921 6.5589 -3.9197 38.8932
SNU-5 GDSC1; GDSC2 -1.5274 5.5761 -3.4784 28.932
MKN45 GDSC2; CCLE -1.0968 3.0576 -1.4868 28.7058
SNU-1 GDSC1; GDSC2; CCLE 0.0159 5.7399 -1.2666 24.5734
HSC-39 GDSC1; GDSC2 0.2485 3.0419 -0.5403 11.4995
TGBC11TKB GDSC1; GDSC2 0.4204 9.0808 -3.3322 22.8938
GCIY GDSC1; GDSC2; CCLE 0.5693 8.7848 -2.1037 25.8771
Fu97 GDSC1; GDSC2; CCLE 0.5916 7.8406 -1.635 24.2801
Hs 746.T GDSC1; GDSC2; CCLE 0.8288 10.21 -2.5429 26.5513
ECC10 GDSC1; GDSC2 1.0865 4.6215 -0.5279 9.3076
IM95 GDSC1; GDSC2; CCLE 1.2462 7.4443 -0.8116 19.6481
KATO III GDSC1; GDSC2 1.3326 6.2436 -1.13 11.5759
NUGC-3 GDSC1; GDSC2; CCLE 1.4032 11.0228 -2.4091 24.7479
AZ-521 CCLE 1.6003 10.358 -1.9019 27.7381
MKN28 GDSC1; GDSC2 1.7898 11.285 -3.2753 19.5094
NCI-N87 GDSC1; GDSC2; CCLE 1.9421 10.2187 -1.5249 20.6094
KE-39 CCLE 2.3645 8.6279 -0.3596 19.3402
SNU-16 GDSC1; GDSC2; CCLE 2.5081 4.4916 1.8129 6.0461
23132/87 GDSC1; GDSC2 2.9216 12.1288 -2.8132 15.5205
RERF-GC-1B GDSC2; CCLE 3.1343 17.0147 -3.8958 25.1135
RF-48 GDSC1; GDSC2 3.1364 7.6418 -0.4841 5.3227
SCH GDSC1; GDSC2 3.2374 4.7642 0.8186 0.3779
ECC12 GDSC2 3.4327 4.9716 0.8195 0.2527
MKN74 CCLE 3.6116 13.5777 -1.7883 21.9345
MKN1 GDSC1; GDSC2 3.8161 12.1765 -2.1936 11.5261
BGC-823 CCLE 4.303 7.5944 1.6767 4.5003
SK-GT-2 GDSC1; GDSC2 4.4613 14.112 -2.6838 12.391
MKN7 GDSC1; GDSC2; CCLE 4.9821 15.3338 -1.6031 15.0394
HGC-27 GDSC1; GDSC2; CCLE 5.6594 7.8969 2.2574 0.4822
SH-10-TC CCLE 7.1036 16.8017 -0.8543 11.5547
SNG-M GDSC1; GDSC2; CCLE 3.4362 8.5652 0.572 9.4014
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 17 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KMH-2 GDSC1; GDSC2 -6.1133 1.657 -6.8863 60.2884
BHT-101 GDSC1; GDSC2 -4.7034 0.6142 -5.0748 45.9145
K5 GDSC2 -3.7102 6.1253 -5.9514 42.4043
TT2609-C02 GDSC1; GDSC2; CCLE -3.1025 6.1817 -4.7357 43.4894
IHH-4 GDSC1; GDSC2 -2.0863 6.4456 -4.436 33.6007
HTC-C3 GDSC1; GDSC2 -1.091 13.3246 -6.7924 35.5209
8305C GDSC1; GDSC2; CCLE 0.7775 14.8254 -4.8536 32.2225
CAL-62 GDSC1; GDSC2 0.8776 9.8907 -3.3381 21.7965
8505C GDSC1; GDSC2; CCLE 0.8905 12.0688 -3.3934 28.724
ML-1 [Human leukemia] GDSC1; GDSC2 1.5926 5.4643 -0.5282 10.8973
B-CPAP GDSC1; GDSC2; CCLE 1.8371 14.6032 -3.797 27.5392
SW579 CCLE 2.2303 5.6504 0.9891 12.9632
ASH-3 GDSC1; GDSC2 2.2948 13.3442 -3.8989 20.5914
CGTH-W-1 GDSC1; GDSC2 2.6262 8.4069 -1.2012 9.3419
TT GDSC1; GDSC2 3.8974 13.3942 -2.7259 13.4608
WRO GDSC1; GDSC2 4.3617 13.1437 -2.288 11.0344
FTC-133 GDSC1; GDSC2 5.4284 16.0195 -2.9511 11.9191
⏷ Show the Full List of 17 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 42 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UPCI-SCC-090 GDSC1; GDSC2 -4.1625 5.4282 -6.1295 44.4217
DOK GDSC1; GDSC2 -3.7787 11.4876 -8.4538 44.853
BB30-HNC GDSC1; GDSC2 -3.526 4.9083 -5.2468 45.5035
JHU-011 GDSC1; GDSC2 -2.6155 8.6496 -5.981 42.4103
PCI-38 GDSC1 -2.5662 2.1057 -4.5419 21.4026
BHY GDSC1; GDSC2 -1.2951 5.1726 -3.0612 34.0945
CAL-27 GDSC1; GDSC2; CCLE -0.8502 8.3183 -3.2911 33.1806
JHU-029 GDSC1; GDSC2 -0.8161 13.2482 -6.5049 37.3365
KON GDSC1; GDSC2 -0.7479 19.7913 -9.6897 40.7824
JHU-022 GDSC1; GDSC2 -0.7078 20.3173 -9.9162 38.6039
SAT [Human HNSCC] GDSC1; GDSC2 -0.38 12.6737 -5.828 31.9066
PCI-15A GDSC1; GDSC2 -0.2963 4.2148 -1.6242 20.9293
SAS GDSC1; GDSC2 0.012 7.9033 -3.1154 23.1661
HO-1-N-1 GDSC1; GDSC2 0.0704 7.4924 -2.8597 22.0543
KOSC-2 GDSC1; GDSC2 0.1712 11.5147 -4.7626 31.0189
BB49-HNC GDSC1; GDSC2 0.183 12.2226 -7.3841 22.5588
Ca9-22 GDSC1; GDSC2 0.4234 7.9942 -2.7897 20.8734
SCC-9 GDSC1; GDSC2; CCLE 0.4915 8.867 -2.2181 26.4395
BICR 10 GDSC1; GDSC2 0.9307 12.169 -6.8155 18.9832
HSC-3 GDSC1; GDSC2 1.0512 9.4743 -2.982 20.0839
NCI-H3118 GDSC1; GDSC2 1.0518 16.7879 -6.6373 30.2747
PCI-04B GDSC1; GDSC2 1.2694 10.5214 -3.3216 20.8259
PE/CA-PJ15 GDSC1; GDSC2 1.3404 13.6466 -4.825 28.0731
SCC-4 GDSC1; GDSC2 1.3794 9.1893 -2.5639 17.7077
CAL-33 GDSC1; GDSC2 1.4024 12.2444 -4.0724 23.0456
OSC-19 GDSC1; GDSC2 1.5175 15.9711 -5.8403 30.1134
FaDu GDSC1; GDSC2; CCLE 1.6774 13.2131 -3.2467 26.4968
SCC-25 GDSC1; GDSC2; CCLE 1.8942 9.0276 -0.9786 21.2918
SCC-15 GDSC1; GDSC2 2.2092 10.3364 -2.4689 15.56
BICR 78 GDSC1; GDSC2 2.2467 13.8163 -4.1723 21.5613
BICR 31 GDSC2 2.4489 8.2814 -1.2691 13.0003
LB771-HNC GDSC1; GDSC2 2.4995 5.9694 -0.1089 4.6135
Hs 840.T CCLE 2.625 8.2378 0.0623 16.6116
Detroit 562 GDSC1; GDSC2; CCLE 3.2042 14.1927 -2.4271 20.9167
BICR 22 GDSC1; GDSC2 3.9043 13.48 -2.7626 13.5874
PCI-30 GDSC1; GDSC2 4.3137 11.2309 -1.4166 7.6103
SKN-3 GDSC1; GDSC2 4.4035 18.9225 -5.061 20.2046
PCI-06A GDSC1; GDSC2 4.6392 21.5144 -6.1608 24.5379
HSC-4 GDSC2 4.7075 12.4718 -1.7475 8.3991
OSC-20 GDSC1; GDSC2 4.8993 15.3357 -2.9746 12.7817
HO-1-u-1 GDSC1; GDSC2 5.727 20.201 -4.7466 17.2397
HSC-2 GDSC1; GDSC2; CCLE 7.3871 17.0899 -0.811 8.9292
⏷ Show the Full List of 42 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KU-19-19 GDSC1; GDSC2 -3.3901 1.6985 -3.928 37.1802
BFTC-905 GDSC1; GDSC2 -2.563 2.4704 -3.2789 31.8602
KMBC-2 CCLE -0.1881 4.4108 -0.9455 30.6115
RT-112 GDSC1; GDSC2; CCLE -0.0354 9.8152 -3.1792 30.5683
SW780 GDSC1; GDSC2; CCLE -0.0175 7.2912 -1.9862 27.0967
JMSU-1 CCLE 0.6335 5.2866 -0.4323 25.2445
SCaBER CCLE 0.7212 10.2629 -2.6699 32.8219
CAL-29 GDSC1; GDSC2 1.5369 11.6884 -3.6833 21.4805
RT-4 GDSC1; GDSC2; CCLE 2.5197 8.7066 -0.2628 14.6057
5637 GDSC1; GDSC2; CCLE 2.7234 9.6878 -0.5771 15.4205
SW1710 GDSC1; GDSC2 2.9992 13.5462 -3.4549 17.7133
T24 GDSC1; GDSC2; CCLE 3.018 15.9677 -3.4688 26.6307
639V GDSC1; GDSC2; CCLE 3.1667 17.5085 -4.1158 25.5837
HT-1197 GDSC1; GDSC2; CCLE 3.3091 12.4245 -1.4572 17.5124
TCCSUP GDSC1; GDSC2; CCLE 4.1543 8.8606 0.9671 6.57
UM-UC-3 GDSC1; GDSC2; CCLE 4.73 12.7154 -0.5022 11.4902
J82 GDSC1; GDSC2; CCLE 6.636 17.0871 -1.2924 11.5197
647V GDSC1; GDSC2 7.2748 21.3016 -4.2498 13.642
HT-1376 GDSC1; GDSC2; CCLE 8.4327 21.3515 -2.1399 11.9288
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BPH-1 GDSC1; GDSC2 -3.4645 4.1226 -4.8647 39.6964
CAL-39 GDSC1; GDSC2 -3.3008 4.5994 -4.8834 39.0689
JHOS-3 GDSC1; GDSC2 -2.2358 10.5548 -6.5144 41.69
HEY GDSC1; GDSC2 -1.4021 4.5687 -2.8978 26.4798
SW954 GDSC1; GDSC2 0.1747 8.6358 -3.3301 26.6779
DSH1 GDSC1; GDSC2 0.2215 4.7707 -1.3877 15.4428
OVCA433 GDSC1; GDSC2 0.2814 26.1384 -11.9637 40.4845
ACC-OV7 GDSC1; GDSC2 0.3493 11.5407 -4.619 30.1414
OVMIU GDSC1; GDSC2 0.3965 11.365 -4.4902 26.6532
TC-YIK GDSC1; GDSC2 0.5795 5.8995 -1.6116 15.5358
KGN GDSC1; GDSC2 1.4215 12.9302 -4.3995 24.0043
NT2-D1 GDSC1; GDSC2 1.753 4.4508 0.1006 4.9247
OVCA420 GDSC1; GDSC2 1.7561 15.0914 -5.2044 25.5262
NCC-IT GDSC2 1.9889 4.8783 0.0643 4.6651
OMC-1 [Human cervical carcinoma] GDSC1; GDSC2 2.0171 14.3279 -4.6112 25.8475
DoTc2 4510 GDSC1; GDSC2 2.326 10.1042 -2.2631 14.4899
JEG-3 GDSC1; GDSC2 2.3528 5.9896 -0.2186 6.27
HEC-1 GDSC1; GDSC2 2.5201 5.3477 0.1984 3.2183
PA-1 GDSC1; GDSC2 2.7434 8.5838 -1.2034 9.1454
C-33 A GDSC1; GDSC2 2.7713 13.1511 -3.4324 18.0696
LB831-BLC GDSC1; GDSC2 2.8079 8.7228 -1.2251 9.1299
SW756 GDSC1; GDSC2 2.9131 13.7521 -3.622 18.4517
C-4-I GDSC1; GDSC2 3.3231 19.5515 -6.1836 24.902
HT-3 GDSC1; GDSC2 3.3704 15.3656 -4.0744 19.0857
JAR GDSC1; GDSC2 3.3763 5.151 0.7309 0.5398
NEC8 GDSC1; GDSC2 3.3785 4.9384 0.8105 0.2872
SKN GDSC1; GDSC2 3.3874 9.9813 -1.4308 9.0596
PEO1 GDSC1; GDSC2 3.7013 18.7587 -5.5016 22.5758
PWR-1E GDSC1; GDSC2 3.8094 13.1337 -2.6613 13.3633
SW962 GDSC1; GDSC2 3.9965 16.2527 -4.0488 19.8882
Ca Ski GDSC1; GDSC2 4.1583 17.0517 -4.3226 18.4729
SKG-IIIa GDSC1; GDSC2 4.7245 18.1825 -4.4685 17.977
SiSo GDSC1; GDSC2 5.3095 15.7256 -2.8896 11.8706
UWB1.289 GDSC1; GDSC2 5.4078 20.727 -5.2224 20.8364
ME-180 GDSC1; GDSC2 5.5725 22.4452 -5.9411 20.6424
MS751 GDSC1; GDSC2 5.9195 18.1764 -3.6507 13.6006
OV17R GDSC1; GDSC2 6.0364 24.5465 -6.6345 23.294
HeLa GDSC1; GDSC2 6.3375 17.5828 -3.1057 11.2119
SiHa GDSC1; GDSC2 6.6166 19.8974 -4.011 13.7824
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

References

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2 MEK and the inhibitors: from bench to bedside. J Hematol Oncol. 2013; 6: 27.
3 PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies. Nature. 2014 Oct 9;514(7521):247-51.
4 Blocking downstream signaling pathways in the context of HDAC inhibition promotes apoptosis preferentially in cells harboring mutant Ras. Oncotarget. 2016 Oct 25;7(43):69804-69815. doi: 10.18632/oncotarget.12001.
5 Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer. Cancer Lett. 2014 Jun 1;347(2):204-11. doi: 10.1016/j.canlet.2014.02.018. Epub 2014 Feb 24.
6 U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells. Arch Toxicol. 2014 Dec;88(12):2243-59.