Details of the Drug

General Information of Drug (ID: DM2M3ZA)

• Drug Name: Glycopyrrolate
• Synonyms: GLYCOPYRROLATE; 596-51-0; Glycopyrrolate bromide; Robinul; Gastrodyn; Tarodyl; Nodapton; Tarodyn; Asecryl; Copyrrolate; Cuvposa; Glycopyrronii bromidum; AHR-504; ROBINUL FORTE; Robinal; Robanul; Bromuro de glicopirronio; Bromure de glycopyrronium; NVA-237; AHR 504; Glycopyrronii bromidum [INN-Latin]; EINECS 209-887-0; Bromure de glycopyrronium [INN-French]; Bromuro de glicopirronio [INN-Spanish]; 3-Hydroxy-1,1-dimethylpyrrolidinium bromide

Indication

Disease Entry	ICD 11	Status	REF
Anaesthesia	9A78.6	Approved	[1]
Chronic obstructive pulmonary disease	CA22	Approved	[2]

• Therapeutic Class: Anticholinergic Agents
• ATC Code:
  A03AB02: Glycopyrrolate
  A03AB: Synthetic anticholinergics, quaternary ammonium compounds
  A03A: DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
  A03: DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
  A: ALIMENTARY TRACT AND METABOLISM
  A03AB02: Glycopyrrolate
  A03AB: Synthetic anticholinergics, quaternary ammonium compounds
  A03A: DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
  A03: DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
  A: ALIMENTARY TRACT AND METABOLISM
  A03AB02: Glycopyrrolate
  A03AB: Synthetic anticholinergics, quaternary ammonium compounds
  A03A: DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
  A03: DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
  A: ALIMENTARY TRACT AND METABOLISM
  R03BB06: Glycopyrrolate
  R03BB: Anticholinergics
  R03B: OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
  R03: DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
  R: RESPIRATORY SYSTEM
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight; 398.3
  Logarithm of the Partition Coefficient; Not Available
  Rotatable Bond Count; 5
  Hydrogen Bond Donor Count; 1
  Hydrogen Bond Acceptor Count; 4
• ADMET Property:
  Clearance: The drug present in the plasma can be removed from the body at the rate of 16.8 mL/min/kg [3]
  Half-life: The concentration or amount of drug in body reduced by one-half in 0.65 hours [3]
  Vd: Fluid volume that would be required to contain the amount of drug present in the body at the same concentration as in the plasma 0.37 L/kg [3]
• Chemical Identifiers:
  Formula: C19H28BrNO3
  IUPAC Name: (1,1-dimethylpyrrolidin-1-ium-3-yl) 2-cyclopentyl-2-hydroxy-2-phenylacetate;bromide
  Canonical SMILES: C[N+]1(CCC(C1)OC(=O)C(C2CCCC2)(C3=CC=CC=C3)O)C.[Br-]
  InChI: InChI=1S/C19H28NO3.BrH/c1-20(2)13-12-17(14-20)23-18(21)19(22,16-10-6-7-11-16)15-8-4-3-5-9-15;/h3-5,8-9,16-17,22H,6-7,10-14H2,1-2H3;1H/q+1;/p-1
  InChIKey: VPNYRYCIDCJBOM-UHFFFAOYSA-M
• Cross-matching ID:
  PubChem CID: 11693
  ChEBI ID: CHEMBL90972
  CAS Number: 596-51-0
  TTD ID: D0M0AM
  VARIDT ID: DR01412
  ACDINA ID: D00305
• Drug-Molecule Activity Atlas (DMA)NEW: Click to Jump to the Detailed DMA Information of This Drug
• Drug Pharmacogenomic Perturbation (DPP)NEW: Click to Jump to the Detailed DPP Information of This Drug
• Drug ADMET Endpoint Profile (DAE)NEW: Click to Jump to the Detailed DAE Information of This Drug
• Repurposed Drugs (RPD): Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Muscarinic acetylcholine receptor M1 (CHRM1)	TTZ9SOR	ACM1_HUMAN	Antagonist	[4]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Organic cation transporter 1 (SLC22A1)	DTT79CX	S22A1_HUMAN	Substrate	[5]

Molecular Expression Atlas of This Drug

• The Studied Disease: Anaesthesia
• ICD Disease Classification: 9A78.6

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Muscarinic acetylcholine receptor M1 (CHRM1)	DTT	CHRM1	4.61E-07	-0.59	-0.73
Organic cation transporter 1 (SLC22A1)	DTP	SLC22A1	8.54E-01	1.24E-02	7.20E-02

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG

DIG Name	DIG ID	PubChem CID	Functional Classification
Beta-D-lactose	E00099	6134	Diluent; Dry powder inhaler carrier; Lyophilization aid
Brushite	E00392	104805	Diluent
Calcium hydrogenphosphate	E00294	24441	Diluent
Calcium pyrophosphate	E00307	24632	Acidulant; Diluent
Calcium stearate	E00244	15324	lubricant
Lactose monohydrate	E00393	104938	Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium stearate	E00208	11177	lubricant
Povidone	E00667	Not Available	Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
Vinylpyrrolidone	E00668	Not Available	Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent

Pharmaceutical Formulation

Formulation Name	Drug Dosage	Dosage Form	Route
Glycopyrrolate 1.5 mg tablet	1.5 mg	Oral Tablet	Oral
Glycopyrrolate 0.0156 mg powder	0.0156 mg	Inhalant Powder	Oral
Glycopyrrolate 1 mg tablet	1 mg	Oral Tablet	Oral
Glycopyrrolate 2 mg tablet	2 mg	Oral Tablet	Oral

Jump to Detail Pharmaceutical Formulation Page of This Drug

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7459).
• [2] Clinical pipeline report, company report or official report of Novartis.
• [3] Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
• [4] Autonomic cardiovascular control during a novel pharmacologic alternative to ganglionic blockade. Clin Pharmacol Ther. 2008 May;83(5):692-701.
• [5] Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42.