Details of the Drug

General Information of Drug (ID: DM2QBHP)

Drug Name

Eteplirsen

Synonyms

AVI-4658

Indication

Disease Entry	ICD 11	Status	REF
Duchenne dystrophy	8C70	Approved	[1]

ATC Code

M09AX06: Eteplirsen

M09AX: Other drugs for disorders of the musculo-skeletal system

M09A: OTHER DRUGS FOR DISORDERS OF THE MUSCULO-SKELETAL SYSTEM

M09: OTHER DRUGS FOR DISORDERS OF THE MUSCULO-SKELETAL SYSTEM

M: MUSCULO-SKELETAL SYSTEM

Drug Type

Antisense drug

Sequence

CUCCAACAUCAAGGAAGAUGGCAUUUCUAG

Structure

3D Structure is Not Available

3D MOL is unavailable

2D MOL

ADMET Property

Clearance: The total clearance of drug is 339 mL/h/kg []
Half-life: The concentration or amount of drug in body reduced by one-half in 3.3 hours [2]
Metabolism: The drug is metabolized via the hepatic []
Vd: The volume of distribution (Vd) of drug is 0.6 L/kg []

Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dystrophin messenger RNA (DMD mRNA)	TTWLFXU	DMD_HUMAN	Modulator	[1]

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease

Duchenne dystrophy

ICD Disease Classification

8C70

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Dystrophin messenger RNA (DMD mRNA)	DTT	DMD	1.15E-07	-1.07	-2.94

Molecular Expression Atlas (MEA)

Jump to Detail Molecular Expression Atlas of This Drug

References

1	2016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76.
2	Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds