Details of the Drug

General Information of Drug (ID: DM2UKJV)

Drug Name
SP-333
Synonyms Guanylate cyclase-C receptor agonist (peptide, UC), Synergy Pharmaceuticals; Guanylate cyclase-C receptor analog (peptide, UC), Synergy Pharmaceuticals
Indication
Disease Entry ICD 11 Status REF
Ulcerative colitis DD71 Phase 2 [1]
Cross-matching ID
PubChem CID
91826710
TTD ID
D05YLP

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Guanylyl cyclase C (GUCY2C) TTLDPRG GUC2C_HUMAN Agonist [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Ulcerative colitis
ICD Disease Classification DD71
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Guanylyl cyclase C (GUCY2C) DTT GUCY2C 9.52E-03 2.35 5.13
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 ClinicalTrials.gov (NCT01983306) Dose-ranging Study to Assess Safety and Efficacy of SP-333 for the Treatment of Opioid-induced Constipation (OIC). U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)