Details of the Drug

General Information of Drug (ID: DM3415L)

Drug Name

BAX-499

Synonyms

ARC-19499; Tissue factor pathway inhibitor (hemophilia A/hemophilia B), Archemix

Indication

Disease Entry	ICD 11	Status	REF
Factor IX deficiency	3B11	Phase 1	[1]
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Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tissue factor pathway inhibitor (TFPI)	TT068JH	TFPI1_HUMAN	Inhibitor	[2]

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Molecular Interaction Atlas (MIA)

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Molecular Expression Atlas of This Drug

The Studied Disease

Factor IX deficiency

ICD Disease Classification

3B11

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Tissue factor pathway inhibitor (TFPI)	DTT	TFPI	1.27E-08	0.14	0.84

Molecular Expression Atlas (MEA)

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References

1	ClinicalTrials.gov (NCT01191372) First-in-Human and Proof-of-Mechanism Study of ARC19499 Administered to Hemophilia Patients. U.S. National Institutes of Health.
2	Aptamer BAX 499 mediates inhibition of tissue factor pathway inhibitor via interaction with multiple domains of the protein. J Thromb Haemost. 2013 Jun;11(6):1137-45.