Details of the Drug

General Information of Drug (ID: DM3CZVW)

• Drug Name: N-(2-Flouro-Benzyl)-4-Sulfamoyl-Benzamide
• Synonyms: n-(2-flouro-benzyl)-4-sulfamoyl-benzamide; N-[(2-fluorophenyl)methyl]-4-sulfamoylbenzamide; n-(2-fluoro-benzyl)-4-sulfamoyl-benzamide; 2-fluoro-SBB; 1g1d; AC1L1HTZ; SCHEMBL678599; BDBM12014; 1g45; AKOS008607291; DB02069; n-(2-fluorobenzyl)-4-sulfamoylbenzamide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 308.33
  Logarithm of the Partition Coefficient (xlogp); 1
  Rotatable Bond Count (rotbonds); 4
  Hydrogen Bond Donor Count (hbonddonor); 2
  Hydrogen Bond Acceptor Count (hbondacc); 5
• Chemical Identifiers:
  Formula: C14H13FN2O3S
  IUPAC Name: N-[(2-fluorophenyl)methyl]-4-sulfamoylbenzamide
  Canonical SMILES: C1=CC=C(C(=C1)CNC(=O)C2=CC=C(C=C2)S(=O)(=O)N)F
  InChI: InChI=1S/C14H13FN2O3S/c15-13-4-2-1-3-11(13)9-17-14(18)10-5-7-12(8-6-10)21(16,19)20/h1-8H,9H2,(H,17,18)(H2,16,19,20)
  InChIKey: ULYMHSXFSKOHGH-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 4290
  DrugBank ID: DB02069
  TTD ID: D0U7GL

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[1]

Molecular Expression Atlas of This Drug

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Carbonic anhydrase II (CA-II)	DTT	CA2	7.95E-08	0.52	0.33

References

• [1] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.