Details of the Drug

General Information of Drug (ID: DM3H0IX)

Drug Name

AMG 890

Synonyms

Olpasiran

Indication

Disease Entry	ICD 11	Status	REF
Cardiac fibrosis	DB98.8	Phase 2	[1]
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Drug Type

Small interfering RNA

Sequence

>Subunit 1
UCGUAUAACAAUAAGGGGCUG
>Subunit 2
CAGCCCCUUAUUGUUAUACGA

Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Apolipoprotein A messenger RNA (LPA mRNA)	TTU9LGY	APOA_HUMAN	Inhibitor	[2]

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Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	ClinicalTrials.gov (NCT04270760) Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction - DOSE Finding Study. U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of Amgen.