Details of the Drug

General Information of Drug (ID: DM3LDFB)

Drug Name

Simoctocog alfa

Synonyms

Factor VIII - Octapharma; Human-cl rhFVIII - Octapharma; Nuwiq

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

ADMET Property

Clearance: The clearance of drug is 2.96 +/- 0.97 mL/h/kg [2]
Half-life: The concentration or amount of drug in body reduced by one-half in 12.50 +/- 4.17 hours (in pediatric patients) [2]
Vd: The volume of distribution (Vd) of drug is 0.05975 L/kg [2]

Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Coagulation factor VIII (F8)	TT1290U	FA8_HUMAN	Modulator	[1]

Molecular Interaction Atlas (MIA)

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Molecular Expression Atlas of This Drug

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Coagulation factor VIII (F8)	DTT	F8	1.08E-22	0.89	1.82

Molecular Expression Atlas (MEA)

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References

1	A new recombinant factor VIII: from genetics to clinical use
2	Nuwiq Product Monograph