Details of the Drug

General Information of Drug (ID: DM3RSMF)

Drug Name
SGX523
Synonyms SGX-523; SGX523, SGX-523
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
Therapeutic Class
Anticancer Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 359.4
Logarithm of the Partition Coefficient (xlogp) 2.4
Rotatable Bond Count (rotbonds) 3
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C18H13N7S
IUPAC Name
6-[[6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl]quinoline
Canonical SMILES
CN1C=C(C=N1)C2=NN3C(=NN=C3SC4=CC5=C(C=C4)N=CC=C5)C=C2
InChI
InChI=1S/C18H13N7S/c1-24-11-13(10-20-24)16-6-7-17-21-22-18(25(17)23-16)26-14-4-5-15-12(9-14)3-2-8-19-15/h2-11H,1H3
InChIKey
BCZUAADEACICHN-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
24779724
ChEBI ID
CHEBI:90624
CAS Number
1022150-57-7
UNII
WH8SQN09KJ
DrugBank ID
DB06314
TTD ID
D0ZU5F
INTEDE ID
DR1802
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Proto-oncogene c-Met (MET) TTNDSF4 MET_HUMAN Inhibitor [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Aldehyde oxidase (AOX1)
Main DME 		DEAWHS8 AOXA_HUMAN Substrate [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Solid tumour/cancer
ICD Disease Classification 2A00-2F9Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Proto-oncogene c-Met (MET) DTT MET 1.08E-03 -0.24 -0.4
Aldehyde oxidase (AOX1) DME AOX1 8.82E-01 -1.51E-02 -3.80E-02
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 148 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MEC1 CTRP2 7.2638 11.5073 4.2503 5.4845
JK1 CTRP2 8.195 12.7894 4.2511 4.2544
JM1 CTRP2 7.2118 11.3857 4.273 5.4692
REC-1 CTRP2 4.8484 7.6263 4.1218 10.731
HH [Human lymphoma] CTRP2 5.6166 10.5995 3.4012 11.94
KMS-20 CTRP2 6.1509 8.7895 4.7596 5.1984
MOLM-13 CTRP2 6.2699 8.2053 5.1457 3.3642
BDCM CTRP2 6.2743 8.205 5.1492 3.3417
RS4;11 CTRP2 6.2907 8.5403 4.9953 3.9569
KMS-21-BM CTRP2 6.3144 8.5184 5.0246 3.793
KMS-34 CTRP2 6.3327 7.5005 5.5404 1.6224
AML-193 CTRP2 6.4629 8.709 5.0427 3.4683
EoL-1 CTRP2 6.5099 10.1524 4.3643 6.212
KMM-1 CTRP2 6.6326 12.1268 3.4784 9.6701
JJN-3 CTRP2 6.6859 8.9221 5.0987 2.8941
EB1 CTRP2 6.6985 12.0052 3.5901 9.0965
BV-173 CTRP2 6.7041 8.7273 5.2049 2.4402
Pfeiffer CTRP2 6.7202 11.2645 3.9739 7.4757
THP-1 CTRP2 6.7833 8.7192 5.2613 2.1088
KYO-1 CTRP2 6.7846 8.3974 5.4126 1.5208
MOLT-3 CTRP2 6.7995 10.8659 4.2304 6.2832
Mino CTRP2 6.8035 8.1682 5.5285 1.0685
P12-Ichikawa CTRP2 6.8101 8.2981 5.4737 1.2621
Ku812 CTRP2 6.8448 10.5893 4.3996 5.5127
MHH-CALL-3 CTRP2 6.856 9.3365 5.0157 2.9853
KMS-12-BM CTRP2 6.8644 8.7654 5.2914 1.8884
NALM-6 CTRP2 6.8856 10.7763 4.3376 5.7032
Mono-Mac-1 CTRP2 6.8973 9.3156 5.0533 2.7786
NU-DHL-1 CTRP2 6.9013 8.8382 5.2806 1.8844
MOLP-8 CTRP2 6.9112 8.5771 5.4068 1.3976
KE-97 CTRP2 6.9294 10.7087 4.4024 5.3688
MOLM-16 CTRP2 6.9308 10.0018 4.7469 3.9618
HuT 78 CTRP2 6.9432 9.2206 5.1283 2.4221
SEM CTRP2 6.9644 8.702 5.3815 1.4323
ALL-SIL CTRP2 6.9687 8.7895 5.3442 1.5651
SUP-M2 CTRP2 6.9855 8.3573 5.5461 0.8321
TALL-1 [Human adult T-ALL] CTRP2 6.9894 10.5941 4.5008 4.8747
GA-10 CTRP2 7.0054 10.2654 4.6712 4.1595
SU-DHL-1 CTRP2 7.0189 8.1681 5.6428 0.5026
Ci-1 CTRP2 7.0461 7.8347 5.7848 0.1424
M-07e CTRP2 7.052 8.7952 5.3902 1.3082
NU-DUL-1 CTRP2 7.0707 11.4618 4.1361 6.2398
F-36P CTRP2 7.0838 8.9099 5.3571 1.3941
CML-T1 CTRP2 7.0848 8.6548 5.4703 0.9977
DB CTRP2 7.0886 9.4776 5.1003 2.3476
KMS-27 CTRP2 7.0893 9.0477 5.2983 1.6018
Daudi CTRP2 7.0931 11.0654 4.3451 5.3531
HPB-ALL CTRP2 7.0955 11.7577 4.0093 6.719
HEL CTRP2 7.1107 10.7265 4.5214 4.6124
HEL 92.1.7 CTRP2 7.1153 11.3929 4.2015 5.9042
ST486 CTRP2 7.1433 9.7318 5.0163 2.6039
DEL CTRP2 7.1607 8.319 5.6482 0.3991
Karpas-422 CTRP2 7.1776 10.9443 4.4624 4.7536
OCI-AML-3 CTRP2 7.1886 9.8078 5.0093 2.5749
LP-1 CTRP2 7.194 11.8102 4.0543 6.3833
Peer CTRP2 7.1948 9.2434 5.2714 1.5874
U-937 CTRP2 7.1963 8.7277 5.4975 0.8137
OCI-AML-5 CTRP2 7.1972 8.2788 5.6801 0.3011
HL-60 CTRP2 7.1988 9.0993 5.3379 1.3467
KMS-11 CTRP2 7.203 10.339 4.7689 3.4939
U266B1 CTRP2 7.2085 10.1744 4.8502 3.167
MC116 CTRP2 7.2096 8.2803 5.6848 0.2842
JeKo-1 CTRP2 7.2389 12.1313 3.9299 6.8205
JURL-MK1 CTRP2 7.2546 9.1522 5.3455 1.2667
OCI-Ly3 CTRP2 7.2894 9.6177 5.1577 1.8999
MOTN-1 CTRP2 7.2956 9.7579 5.0977 2.1148
EM-2 CTRP2 7.3144 9.0992 5.4005 1.0289
NOMO-1 CTRP2 7.317 11.43 4.3242 5.1099
L-1236 CTRP2 7.3224 11.9232 4.09 6.0459
SU-DHL-6 CTRP2 7.3402 13.2959 3.4337 8.6675
ME1 CTRP2 7.3436 9.0989 5.4158 0.9554
SUP-T1 CTRP2 7.3589 9.6372 5.1891 1.7133
Hs 611.T CTRP2 7.3595 9.8292 5.1031 2.0242
SKM-1 CTRP2 7.3655 8.5539 5.6465 0.3003
A4/Fukuda CTRP2 7.3676 19.0333 0.6171 18.7886
PF-382 CTRP2 7.4187 10.0646 5.0313 2.2236
A3/Kawakami CTRP2 7.4228 14.5492 2.8789 10.7325
DND-41 CTRP2 7.4308 12.6162 3.8299 6.9336
BL-70 CTRP2 7.441 12.6699 3.811 6.9943
SUP-B15 CTRP2 7.4481 9.988 5.0831 2.0023
Kasumi-2 CTRP2 7.463 12.774 3.776 7.1023
OCI-Ly19 CTRP2 7.4672 9.0948 5.4786 0.6746
OCI-M1 CTRP2 7.4922 9.8542 5.1679 1.6555
Granta-519 CTRP2 7.496 9.4725 5.3355 1.0883
TF-1 CTRP2 7.5001 8.9683 5.5444 0.4774
SUP-T11 CTRP2 7.5186 9.6154 5.2862 1.2293
MHH-CALL-4 CTRP2 7.5215 13.6867 3.3734 8.6246
Ri-1 CTRP2 7.5497 12.6259 3.908 6.4448
RPMI-8402 CTRP2 7.5796 9.4577 5.3838 0.8743
SR CTRP2 7.5946 9.1938 5.4979 0.5445
RPMI-6666 CTRP2 7.5965 11.4168 4.5154 3.9753
SU-DHL-10 CTRP2 7.6023 8.4898 5.7602 0.0563
SU-DHL-4 CTRP2 7.6175 9.1141 5.5392 0.4297
MOLT-16 CTRP2 7.6286 9.2623 5.4861 0.5558
K-562 CTRP2 7.657 9.1752 5.5327 0.4259
P3HR-1 CTRP2 7.6676 15.1408 2.7678 10.7687
SU-DHL-8 CTRP2 7.6717 14.0006 3.3274 8.577
KMS-18 CTRP2 7.7063 9.513 5.4217 0.6817
AMO1 CTRP2 7.7074 9.0524 5.6002 0.2609
L-540 CTRP2 7.7315 9.5787 5.407 0.7064
L-428 CTRP2 7.7531 9.8057 5.3247 0.9267
SIG-M5 CTRP2 7.7564 8.6691 5.7531 0.0446
697 CTRP2 7.7704 13.389 3.692 6.9868
PL21 CTRP2 7.7817 9.9716 5.2699 1.0707
LAMA-84 CTRP2 7.7986 10.2153 5.1757 1.3538
NCI-H929 CTRP2 7.8033 9.4632 5.4848 0.468
OCI-AML-2 CTRP2 7.8061 8.9675 5.6687 0.1234
NB4 CTRP2 7.8115 8.6754 5.7697 0.0291
KCL-22 CTRP2 7.8147 10.5769 5.028 1.8325
SET-2 CTRP2 7.8267 17.4647 1.743 14.289
Karpas-299 CTRP2 7.8433 9.2556 5.5796 0.2531
KMS-26 CTRP2 7.849 8.9129 5.703 0.0767
Raji CTRP2 7.8514 9.2951 5.5683 0.2713
RL CTRP2 7.8786 9.3774 5.5488 0.2988
RCH-ACV CTRP2 7.9495 10.4094 5.1707 1.2495
Reh CTRP2 7.9543 9.4425 5.555 0.2613
EHEB CTRP2 7.9892 10.361 5.2106 1.0984
KM-H2 CTRP2 7.9894 13.7791 3.6533 6.8303
EJM CTRP2 7.9996 9.6118 5.5107 0.329
WSU-DLCL2 CTRP2 8.0026 9.0997 5.6934 0.0653
MOLM-6 CTRP2 8.0239 9.854 5.4293 0.4928
P31/FUJ CTRP2 8.0255 9.1228 5.6935 0.0624
RPMI-8226 CTRP2 8.0275 15.2129 2.9892 9.3618
SK-MM-2 CTRP2 8.029 9.5444 5.5472 0.2515
JVM-3 CTRP2 8.0329 15.9289 2.6453 10.6655
MM1.S CTRP2 8.0392 11.313 4.8281 2.3108
KE-37 CTRP2 8.0484 9.1141 5.7043 0.0515
MOLT-13 CTRP2 8.0528 9.5833 5.5424 0.2526
Kasumi-1 CTRP2 8.0575 13.1161 4.0125 5.3377
OCI-Ly10 CTRP2 8.0793 10.4335 5.2244 0.9958
HDLM-2 CTRP2 8.0902 10.4066 5.2405 0.9427
HT CTRP2 8.0982 9.5772 5.5621 0.2073
Mono-Mac-6 CTRP2 8.1348 11.8207 4.6562 2.8249
L-363 CTRP2 8.1417 9.4567 5.6206 0.1181
KHM-1B CTRP2 8.1534 11.1233 4.9725 1.7169
OPM-2 CTRP2 8.1613 9.5914 5.5808 0.1646
KO52 CTRP2 8.1738 14.0552 3.6443 6.6132
CA46 CTRP2 8.1804 10.4357 5.2708 0.8042
Jurkat CTRP2 8.2173 13.7079 3.8369 5.8102
Toledo CTRP2 8.2342 10.3752 5.3188 0.6523
MOLP-2 CTRP2 8.3082 9.8828 5.5326 0.1986
Namalwa CTRP2 8.321 9.9002 5.5313 0.1975
Ki-JK CTRP2 8.4828 10.0188 5.5492 0.1402
NCO2 CTRP2 8.7025 10.6322 5.4146 0.277
GDM-1 CTRP2 8.8076 10.4536 5.5158 0.1233
SUP-HD1 CTRP2 8.821 18.4415 1.9795 11.9148
HD-MY-Z CTRP2 10.4144 20.6688 1.9741 9.7994
CMK CTRP2 12.2229 21.6744 2.5795 5.9064
⏷ Show the Full List of 148 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE8 CTRP2 7.3606 10.1708 4.9476 2.6033
TE15 CTRP2 8.5902 12.2163 4.7328 2.1302
TE-5 CTRP2 6.9348 9.5858 4.9495 3.1407
TE-6 CTRP2 6.95 11.6375 3.962 8.8975
KYSE-30 CTRP2 7.2431 9.9733 4.9664 2.6729
KYSE-510 CTRP2 7.3199 10.3536 4.8374 3.0753
KYSE-70 CTRP2 7.4514 10.2625 4.9606 2.4497
TE-4 CTRP2 7.5037 10.6136 4.8311 2.8761
TE-10 CTRP2 7.723 11.0667 4.756 2.9051
KYSE-450 CTRP2 7.7278 9.2061 5.551 0.3529
KYSE-140 CTRP2 7.8035 13.8719 3.482 7.7693
KYSE-150 CTRP2 7.8255 9.2047 5.5912 0.2381
OE19 CTRP2 7.9777 9.093 5.687 0.0742
TE-11 CTRP2 8.069 12.7702 4.1818 4.6705
TE-9 CTRP2 8.1421 9.8509 5.4795 0.3379
TE-14 CTRP2 8.1757 9.7383 5.5339 0.2309
TE-1 CTRP2 8.2781 10.1917 5.4078 0.43
COLO 680N CTRP2 8.3044 10.259 5.3934 0.4497
EC-GI-10 CTRP2 8.4863 10.1372 5.5091 0.1905
KYSE-410 CTRP2 8.5233 15.9514 2.9734 8.7078
OE21 CTRP2 8.5627 10.2321 5.5041 0.1807
KYSE-520 CTRP2 8.9928 11.1691 5.3329 0.3279
KYSE-180 CTRP2 9.3155 17.8111 2.6127 8.971
OE33 CTRP2 10.3486 31.2099 -3.1563 23.3433
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 7.7015 9.4505 5.4445 0.6233
KP-4 CTRP2 3.6834 12.5997 0.6385 26.5603
SNU-410 CTRP2 5.5502 12.7342 2.2792 16.5512
Capan-1 CTRP2 7.0445 8.8464 5.363 1.414
HuP-T4 CTRP2 7.0845 9.6173 5.0325 2.6149
SU.86.86 CTRP2 7.1462 8.5442 5.5494 0.6907
Hs 766T CTRP2 7.2707 9.9774 4.9816 2.5811
Capan-2 CTRP2 7.4104 10.4595 4.8448 2.9353
PK-45H CTRP2 7.563 11.0345 4.6728 3.4085
TCC-Pan2 CTRP2 7.5644 10.5724 4.8867 2.5972
Panc 05.04 CTRP2 7.5926 9.1558 5.512 0.5096
SNU-213 CTRP2 7.5963 8.9375 5.5977 0.308
PaTu 8988t CTRP2 7.6193 8.7254 5.6845 0.1437
HuP-T3 CTRP2 7.6722 12.8936 3.8631 6.448
MIA PaCa-2 CTRP2 7.7826 9.3229 5.5297 0.3758
Panc 08.13 CTRP2 7.8546 9.9062 5.3323 0.8363
DAN-G CTRP2 7.8746 9.5344 5.488 0.4276
CFPAC-1 CTRP2 7.905 9.7997 5.3982 0.6285
QGP-1 CTRP2 7.9304 9.3897 5.5649 0.2514
PaTu 8902 CTRP2 7.9554 9.1415 5.6624 0.1029
Panc 02.03 CTRP2 7.9757 10.4418 5.1702 1.2309
YAPC CTRP2 7.9905 9.0704 5.699 0.0619
SW1990 CTRP2 8.1165 11.5006 4.7883 2.3748
SUIT-2 CTRP2 8.1987 9.4771 5.634 0.0944
L3.3 CTRP2 8.2173 9.4068 5.6643 0.0646
Panc 03.27 CTRP2 8.235 9.7242 5.5614 0.1748
PSN1 CTRP2 8.2665 11.2648 4.9708 1.629
KP-3 CTRP2 8.2713 10.5989 5.2473 0.8137
HPAF-II CTRP2 8.3719 10.3036 5.4044 0.4009
HPAC CTRP2 8.4701 10.1247 5.5075 0.1963
PK-59 CTRP2 8.4731 10.9461 5.201 0.82
Panc 04.03 CTRP2 8.4891 10.1761 5.4965 0.2076
PaTu 8988s CTRP2 8.5811 10.139 5.5431 0.1301
AsPC-1 CTRP2 8.8715 10.7628 5.4318 0.2109
BxPC-3 CTRP2 8.9312 10.9942 5.3722 0.2825
KP-2 CTRP2 9.2355 15.6952 3.5478 5.6593
Panc 10.05 CTRP2 12.6333 29.0965 -0.5621 14.6103
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 49 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 8.0419 10.466 4.2438 0.5039
Hs 940.T CTRP2 6.4811 11.8266 3.5087 9.8165
Hs 688(A).T CTRP2 6.6807 11.2259 3.963 7.588
Hs 934.T CTRP2 6.7107 11.1145 4.0409 7.2143
Hs 839.T CTRP2 6.8157 15.1983 2.0933 14.7749
RPMI-7951 CTRP2 6.8704 9.0802 5.1474 2.4423
SK-MEL-28 CTRP2 6.9807 8.0646 5.6668 0.459
CJM [Human melanoma] CTRP2 7.0855 8.671 5.4637 1.0194
MDA-MB-435S CTRP2 7.1895 9.1031 5.331 1.3801
LOX-IMVI CTRP2 7.2434 9.0465 5.3855 1.1405
IGR-37 CTRP2 7.3929 9.1071 5.4373 0.8495
SK-MEL-2 CTRP2 7.4345 8.5294 5.6839 0.1979
WM1799 CTRP2 7.4475 8.6214 5.6551 0.2486
UACC-62 CTRP2 7.4518 11.4872 4.3877 4.6682
RVH-421 CTRP2 7.5642 9.3529 5.4195 0.7796
HMCB CTRP2 7.6605 8.965 5.6137 0.2518
K029AX CTRP2 7.6778 9.206 5.5299 0.4227
SK-MEL-30 CTRP2 7.6855 8.927 5.6375 0.2008
A101D CTRP2 7.7367 9.0966 5.5956 0.2594
UACC-257 CTRP2 7.7421 9.2972 5.5224 0.4099
Mel JuSo CTRP2 7.7689 10.0563 5.2279 1.2113
SK-MEL-5 CTRP2 7.7761 8.7398 5.7362 0.0558
MeWo CTRP2 7.7767 9.8635 5.3124 0.9467
WM115 CTRP2 7.8111 9.5727 5.4456 0.5593
SK-MEL-3 CTRP2 7.8716 9.569 5.4735 0.4621
Mel Ho CTRP2 7.9103 9.1201 5.6535 0.1217
IGR-1 CTRP2 7.9139 9.3195 5.584 0.2234
Hs 936.T CTRP2 7.9351 9.176 5.6431 0.13
A2058 CTRP2 7.9707 9.1179 5.676 0.0858
SK-MEL-1 CTRP2 8.0241 9.3936 5.5995 0.1698
IPC-298 CTRP2 8.0604 9.1444 5.6983 0.0548
WT2-iPS CTRP2 8.0945 9.205 5.6897 0.0578
WM88 CTRP2 8.1095 9.3531 5.6447 0.0969
HT-144 CTRP2 8.1457 14.6786 3.3281 7.8795
Hs 852.T CTRP2 8.153 9.6315 5.5635 0.1911
WM793 CTRP2 8.1659 9.775 5.5169 0.2621
SK-MEL-31 CTRP2 8.1727 10.0652 5.4118 0.4654
WM266-4 CTRP2 8.1891 9.6551 5.5687 0.1751
G-361 CTRP2 8.3025 9.7488 5.5775 0.1397
A-375 CTRP2 8.3969 9.9289 5.5493 0.1565
COLO 792 CTRP2 8.4818 10.19 5.4888 0.2205
COLO 800 CTRP2 8.4854 10.0648 5.5342 0.1578
COLO 829 CTRP2 8.5107 10.5316 5.3759 0.4058
Hs 944.T CTRP2 8.5734 15.3225 3.3058 7.3797
SK-MEL-24 CTRP2 8.7176 12.2408 4.7883 1.8473
WM983B CTRP2 8.9306 16.1751 3.135 7.5551
Hs 294T CTRP2 9.5016 19.274 2.0415 10.7435
IGR-39 CTRP2 11.4187 22.0633 1.947 8.7221
Hs 895.T CTRP2 11.5484 26.6947 -0.1327 14.7803
⏷ Show the Full List of 49 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 CTRP2 8.1044 10.7401 5.1098 1.3196
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MHH-NB-11 CTRP2 6.8952 12.314 3.5874 8.7711
IMR-32 CTRP2 7.1684 8.8216 5.4428 1.0153
KP-N-YN CTRP2 7.1997 13.9121 3.0269 10.5186
Kelly CTRP2 7.4805 11.1212 4.5798 3.8731
SK-N-DZ CTRP2 7.7293 9.2131 5.549 0.3566
SK-N-AS CTRP2 7.7888 12.4269 4.1636 5.0996
NH-6 CTRP2 7.9085 10.4686 5.1247 1.4276
CHP-126 CTRP2 7.9674 9.3704 5.5863 0.2043
SK-N-BE(2) CTRP2 8.1742 12.5586 4.3447 3.927
NB1 CTRP2 8.1865 9.306 5.6875 0.0503
SK-N-FI CTRP2 8.244 9.5582 5.6223 0.0995
CHP-212 CTRP2 8.42 10.1513 5.4791 0.2514
KP-N-SI9s CTRP2 9.1555 20.3834 1.273 13.82
SK-N-SH CTRP2 9.5819 18.8962 2.2734 9.829
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-1079 CTRP2 4.4048 7.825 3.5811 14.024
HuCC-T1 CTRP2 7.4334 9.0613 5.4761 0.7044
HuH-28 CTRP2 7.8093 9.1174 5.6166 0.1995
SNU-869 CTRP2 7.8135 9.6076 5.433 0.5899
SNU-478 CTRP2 7.9446 9.6751 5.464 0.4501
SNU-1196 CTRP2 8.306 9.7237 5.5876 0.1272
SNU-245 CTRP2 8.3548 11.9833 4.7075 2.4268
SNU-308 CTRP2 8.5516 9.8785 5.6211 0.0628
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hs 822.T CTRP2 6.9549 12.8631 3.3609 9.5917
SK-N-MC CTRP2 7.0764 9.695 4.9908 2.7877
CAL-78 CTRP2 7.2305 9.5153 5.1694 1.9215
SaOS-2 CTRP2 7.2796 10.1841 4.8911 2.9178
SJSA-1 CTRP2 7.3448 10.2191 4.9156 2.7441
Hs 888.T CTRP2 7.387 9.4506 5.2872 1.3431
SK-ES-1 CTRP2 7.4672 9.1574 5.453 0.7486
A-673 CTRP2 7.5124 10.4903 4.8931 2.6325
TC71 CTRP2 7.6157 8.7748 5.6655 0.1744
HOS CTRP2 7.6839 9.7188 5.3268 0.9702
U2OS CTRP2 8.962 11.7288 5.111 0.7887
MHH-ES-1 CTRP2 9.1695 15.7455 3.4847 5.9664
G-292 clone A141B1 CTRP2 9.6001 17.8804 2.7621 8.0729
MG-63 CTRP2 10.1378 18.0077 3.0318 6.4904
SW1353 CTRP2 11.4034 21.9931 1.9699 8.6653
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 65 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KPL-1 CTRP2 6.5704 10.8322 4.0735 7.319
T-47D CTRP2 6.8282 10.2301 4.5633 4.8656
SK-BR-3 CTRP2 7.0816 8.6198 5.4838 0.955
BT-474 CTRP2 7.1927 8.8483 5.4442 0.9895
HCC38 CTRP2 7.2236 10.6509 4.6343 4.0001
HCC202 CTRP2 7.2914 10.818 4.5997 4.0448
DU4475 CTRP2 7.4343 9.901 5.1142 1.9043
MDA-MB-468 CTRP2 7.4479 11.3613 4.445 4.4465
ZR-75-1 CTRP2 7.4663 8.8731 5.5668 0.4395
MDA-MB-453 CTRP2 7.5315 9.1758 5.4761 0.6405
BT-20 CTRP2 7.6267 10.5104 4.9515 2.2906
HCC1395 CTRP2 7.7519 11.6758 4.4926 3.8689
CAL-85-1 CTRP2 7.9093 13.7982 3.59 7.191
HDQ-P1 CTRP2 7.95 9.4171 5.5626 0.2492
HCC1806 CTRP2 7.9983 9.79 5.4428 0.4736
HCC1937 CTRP2 8.0046 10.25 5.2636 0.9331
Hs 578T CTRP2 8.0115 9.7623 5.459 0.4316
JIMT-1 CTRP2 8.0608 9.4032 5.6098 0.1473
MDA-MB-231 CTRP2 8.1033 10.4728 5.2198 0.9928
CAL-51 CTRP2 8.2004 11.3446 4.9021 1.9087
BT-549 CTRP2 8.3043 14.4269 3.5538 6.7883
MCF-7 CTRP2 8.3167 10.0614 5.4716 0.2941
HCC1954 CTRP2 8.341 10.5435 5.3001 0.6435
MDA-MB-361 CTRP2 8.3442 9.8192 5.5683 0.1431
HCC1428 CTRP2 8.3811 9.9905 5.5217 0.1969
HCC1143 CTRP2 8.419 12.9727 4.3021 3.8087
HCC2218 CTRP2 8.4855 10.2122 5.4823 0.2292
ZR-75-30 CTRP2 8.716 10.6566 5.411 0.279
CAMA-1 CTRP2 9.766 23.7425 0.0723 16.5921
HCC1500 CTRP2 11.9374 23.9287 1.4055 9.8512
HMC-1-8 CTRP2 12.5075 22.7844 2.2492 6.6665
BT 328 CTRP2 6.5051 8.5275 5.1628 2.9056
BT 131 CTRP2 6.6977 8.4087 5.3523 1.8634
BT 239 CTRP2 6.8555 9.9317 4.7282 4.1491
BT 359 CTRP2 6.8897 9.7905 4.8205 3.7237
BT 271 CTRP2 6.8969 10.8408 4.3142 5.7815
BT 248 CTRP2 6.9442 10.6146 4.4588 5.1148
BT 416 CTRP2 6.9516 8.8104 5.3244 1.6589
BT164 CTRP2 6.962 9.3256 5.091 2.544
BT 428 CTRP2 7.0927 8.7559 5.4305 1.1266
BT 498 CTRP2 7.1072 8.3648 5.6046 0.5534
BT 112 CTRP2 7.1536 12.7591 3.5606 8.454
BT 330 CTRP2 7.1961 9.9087 4.967 2.7287
BT 172 CTRP2 7.2013 9.7668 5.0362 2.4562
BT 440 CTRP2 7.2502 9.7004 5.0968 2.1694
BT147 CTRP2 7.2701 9.4716 5.2124 1.7218
BT 444 CTRP2 7.2969 8.4749 5.6475 0.3296
BT 231 CTRP2 7.4954 10.8052 4.7372 3.2443
BT 340 CTRP2 7.5002 8.9654 5.5456 0.4744
BT 482 CTRP2 7.5042 8.9247 5.5634 0.4282
BT 139 CTRP2 7.5606 9.9347 5.1702 1.5821
BT 145 CTRP2 7.5983 9.5832 5.3408 0.9913
BT 422 CTRP2 7.5989 9.2445 5.4797 0.5899
BT 179 CTRP2 7.627 9.1039 5.5473 0.4062
BT 320 CTRP2 7.6354 8.7288 5.6894 0.1328
BT 159 CTRP2 7.6539 10.2427 5.0863 1.7837
BT 187 CTRP2 7.7575 10.511 5.0254 1.8956
BT 232 CTRP2 7.8644 12.2989 4.2726 4.5769
BT 286 CTRP2 7.87 9.1412 5.6311 0.1609
BT 216 CTRP2 7.9243 9.3927 5.5614 0.2595
BT 245 CTRP2 7.9494 9.4362 5.5554 0.2622
BT 333 CTRP2 7.9713 9.3633 5.5903 0.1969
BT 228 CTRP2 8.0707 12.5592 4.281 4.2896
BT 504 CTRP2 8.1207 9.2197 5.6938 0.052
BT 224 CTRP2 8.5547 14.975 3.4578 6.8263
⏷ Show the Full List of 65 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 7.3024 10.2242 4.8868 2.9062
Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW1783 CTRP2 5.344 11.6071 2.6597 15.5141
NMC-G1 CTRP2 6.1911 7.2923 5.5381 1.8614
DK-MG CTRP2 6.4036 19.2653 -0.2692 23.1272
SF295 CTRP2 6.6485 10.4696 4.3129 6.1909
CAS-1 CTRP2 6.9412 10.8525 4.3406 5.6039
42-MG-BA CTRP2 7.0057 10.057 4.7717 3.7541
SF539 CTRP2 7.0431 11.2968 4.1968 6.0341
LN-18 CTRP2 7.0887 10.0042 4.8526 3.316
D283 Med CTRP2 7.1049 11.5076 4.1382 6.1781
KNS-81 CTRP2 7.1172 8.3577 5.6123 0.5242
SNU-738 CTRP2 7.2883 9.0589 5.4041 1.0392
KNS-60 CTRP2 7.3148 8.5206 5.6376 0.3444
SNU-201 CTRP2 7.3987 9.9139 5.0878 2.038
SNU-489 CTRP2 7.4854 8.8669 5.5776 0.4033
CCF-STTG1 CTRP2 7.5289 11.7639 4.3071 4.8825
SF126 CTRP2 7.542 9.7948 5.2212 1.4256
U-251MG CTRP2 7.6061 11.2923 4.5797 3.7139
SNU-466 CTRP2 7.6644 8.8556 5.6551 0.1775
SF268 CTRP2 7.7799 11.4623 4.6089 3.3918
SNU-626 CTRP2 7.8107 9.188 5.5914 0.2423
KG-1-C CTRP2 7.8747 13.1339 3.8845 6.0804
U-87MG ATCC CTRP2 7.8821 18.7509 1.1501 16.2109
SW1088 CTRP2 7.9266 13.1899 3.8922 5.9796
GaMG CTRP2 7.945 12.4019 4.2755 4.4644
ONS-76 CTRP2 7.9592 11.5458 4.6781 2.9315
KNS-42 CTRP2 8.0078 10.0451 5.3475 0.7018
8-MG-BA CTRP2 8.0657 15.0427 3.0981 8.8853
GB-1 CTRP2 8.1791 13.6793 3.8256 5.9034
Daoy CTRP2 8.1819 14.0653 3.6448 6.6002
DBTRG-05MG CTRP2 8.2605 12.609 4.3734 3.7218
TM-31 CTRP2 8.3003 15.8731 2.8593 9.4567
Becker CTRP2 8.3389 19.0861 1.3229 14.8983
M059K CTRP2 8.3616 16.6574 2.523 10.6282
T98G CTRP2 8.3713 13.9098 3.8405 5.6004
A-172 CTRP2 8.378 10.5456 5.3153 0.5899
LN-229 CTRP2 8.4447 10.4061 5.3958 0.3909
GOS-3 CTRP2 8.5841 14.3826 3.7539 5.6652
KALS-1 CTRP2 8.9028 14.8059 3.7545 5.2833
SNB-75 CTRP2 8.9687 15.3956 3.5229 6.0635
Hs 683 CTRP2 9.191 20.2211 1.3763 13.4295
U-118MG CTRP2 10.3883 21.1288 1.7422 10.6018
YH-13 CTRP2 10.5801 22.1094 1.4042 11.4573
GMS-10 CTRP2 11.398 22.1327 1.9029 8.8863
YKG-1 CTRP2 11.8541 24.0611 1.2942 10.2844
SNU-1105 CTRP2 12.8808 26.1716 0.9461 10.2049
⏷ Show the Full List of 45 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HEC-1-A CTRP2 7.2237 11.3679 4.2898 5.3835
EFE-184 CTRP2 7.492 9.4524 5.342 1.0708
ESS-1 CTRP2 7.5067 11.3086 4.5084 4.1184
EN CTRP2 7.5976 10.6961 4.8501 2.696
JHUEM-2 CTRP2 7.6019 10.0933 5.1233 1.7048
MFE-296 CTRP2 7.6919 10.0969 5.1705 1.4618
HEC-265 CTRP2 7.7207 8.9612 5.6388 0.1883
JHUEM-1 CTRP2 7.7255 9.7289 5.3429 0.8924
HEC-6 CTRP2 7.7408 9.1474 5.5784 0.2912
HEC-108 CTRP2 7.7548 9.7066 5.3661 0.8056
HEC-151 CTRP2 7.8105 9.2517 5.5679 0.2863
AN3-CA CTRP2 7.8445 11.1516 4.7892 2.6492
RL95-2 CTRP2 7.8806 12.7318 4.0792 5.3086
HEC-1-B CTRP2 7.9168 13.4719 3.7513 6.546
HEC-50B CTRP2 7.9764 9.9622 5.3662 0.6712
HEC-251 CTRP2 8.0909 10.8945 5.0377 1.5577
MFE-319 CTRP2 8.2291 11.8294 4.7058 2.5537
JHUEM-3 CTRP2 8.2763 11.896 4.7026 2.5187
HEC-59 CTRP2 8.3875 14.1752 3.7265 6.0159
JHUEM-7 CTRP2 8.4592 17.609 2.13 11.9169
KLE CTRP2 8.9596 10.7746 5.4598 0.1591
Ishikawa (Heraklio) 02 ER- CTRP2 6.9913 8.708 5.3945 1.356
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RCC10RGB CTRP2 7.0094 10.0017 4.8008 3.632
SNU-1272 CTRP2 7.1861 9.5737 5.1161 2.171
TUHR10TKB CTRP2 7.4474 8.8795 5.5558 0.4773
KMRC-3 CTRP2 7.7479 13.2681 3.7347 6.8495
OS-RC-2 CTRP2 7.761 9.7914 5.3344 0.8927
BFTC-909 CTRP2 7.7667 9.42 5.4857 0.484
A-498 CTRP2 7.8327 19.803 0.5926 18.0621
TUHR4TKB CTRP2 7.8745 9.2803 5.5829 0.2373
KMRC-1 CTRP2 7.8767 10.0252 5.2943 0.9303
Caki-2 CTRP2 8.0668 15.2222 3.0121 9.2152
VMRC-RCW CTRP2 8.1151 15.7968 2.7675 10.0783
CAL-54 CTRP2 8.2072 10.2389 5.3599 0.5671
KMRC-20 CTRP2 8.2689 14.0282 3.7193 6.1969
769-P CTRP2 8.4728 10.06 5.5313 0.164
Caki-1 CTRP2 8.4841 10.5832 5.3458 0.4767
786-O CTRP2 8.6131 10.9877 5.2463 0.6392
UO-31 CTRP2 8.614 19.2603 1.4363 14.0909
ACHN CTRP2 8.7394 12.1303 4.8456 1.653
KMRC-2 CTRP2 9.1895 15.5564 3.5836 5.5814
TUHR14TKB CTRP2 10.4236 28.2031 -1.6314 20.0309
VMRC-RCZ CTRP2 12.5107 23.3991 1.9793 7.4922
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-175 CTRP2 6.2203 22.3381 -1.9564 27.4856
T84 CTRP2 6.902 8.8529 5.2743 1.9078
HCT 116 CTRP2 7.1489 8.6788 5.4939 0.864
CL-11 CTRP2 7.2205 9.9207 4.9767 2.6608
HCT 8 CTRP2 7.3101 8.881 5.4904 0.749
OUMS-23 CTRP2 7.3179 8.3744 5.6944 0.219
CW-2 CTRP2 7.4733 9.8197 5.1726 1.6575
SNU-407 CTRP2 7.5074 9.63 5.274 1.2793
HT-29 CTRP2 7.5115 8.6513 5.6697 0.1985
NCI-H747 CTRP2 7.5242 9.9123 5.16 1.6519
HCC-56 CTRP2 7.5464 8.399 5.7714 0.0533
SNU-C5 CTRP2 7.5583 9.5656 5.328 1.0622
DLD-1 CTRP2 7.5595 8.445 5.7604 0.0618
LS411N CTRP2 7.5676 8.8923 5.6029 0.3088
GP2d CTRP2 7.5684 9.4562 5.3789 0.8972
COLO 678 CTRP2 7.6444 10.1885 5.1048 1.7283
MDST8 CTRP2 7.6525 8.8336 5.6585 0.1754
SNU-C4 CTRP2 7.7236 8.7868 5.7015 0.0988
NCI-H508 CTRP2 7.7305 9.44 5.4618 0.562
SW620 CTRP2 7.7458 9.5651 5.4191 0.665
HCT 15 CTRP2 7.787 9.5016 5.4628 0.5294
COLO205 CTRP2 7.8598 8.9632 5.6896 0.0889
SW948 CTRP2 7.9593 9.4375 5.5588 0.253
SNU-C1 CTRP2 8.0045 9.8266 5.4315 0.4967
SW1417 CTRP2 8.0408 9.5054 5.5659 0.2168
LS513 CTRP2 8.1235 9.5565 5.579 0.1757
SNU-61 CTRP2 8.1295 9.7706 5.5041 0.2962
SK-CO-1 CTRP2 8.1476 9.5527 5.5893 0.156
HT115 CTRP2 8.1566 10.239 5.3378 0.6457
SNU-C2A CTRP2 8.1757 15.5874 2.9112 9.4416
SNU-503 CTRP2 8.1837 9.8461 5.4979 0.2897
RCM-1 [Human ESC] CTRP2 8.1875 9.4828 5.6281 0.1022
COLO201 CTRP2 8.2296 9.3744 5.6793 0.052
LS123 CTRP2 8.2394 9.8703 5.5109 0.2505
CCK-81 CTRP2 8.2722 10.0846 5.4454 0.3571
LS1034 CTRP2 8.3161 10.0051 5.4918 0.2599
HT-55 CTRP2 8.3433 9.7715 5.5845 0.1243
RKO CTRP2 8.4136 14.9917 3.3577 7.3952
SW48 CTRP2 8.5352 10.0903 5.5434 0.1376
KM12 CTRP2 8.5779 10.0999 5.5554 0.1175
LS180 CTRP2 8.6265 9.9606 5.6192 0.0571
LoVo CTRP2 8.6627 15.6436 3.2122 7.6158
NCI-H716 CTRP2 8.6991 10.8483 5.3345 0.4181
C2BBe1 CTRP2 8.8234 10.4807 5.5122 0.1246
COLO 320 CTRP2 9.1703 19.6389 1.6429 12.5693
⏷ Show the Full List of 45 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuH-6 CTRP2 6.6404 9.0407 5.0092 3.3269
JHH-6 CTRP2 7.2321 8.4963 5.6102 0.458
SNU-886 CTRP2 7.3294 9.0863 5.4137 0.9735
Hep 3B2.1-7 CTRP2 7.7569 9.6903 5.3738 0.7825
SNU-761 CTRP2 7.8462 9.7396 5.3955 0.8359
SK-HEP-1 CTRP2 7.9265 9.214 5.6266 0.1541
HuH-1 CTRP2 7.9423 9.2018 5.6367 0.1369
SNU-878 CTRP2 7.949 9.5265 5.5219 0.3256
JHH-1 CTRP2 8.0512 9.3194 5.6355 0.1171
JHH-2 CTRP2 8.1462 10.4288 5.2578 0.8596
SNU-423 CTRP2 8.1553 11.2521 4.9181 1.8951
Hep-G2 CTRP2 8.2294 9.7569 5.5477 0.1957
SNU-398 CTRP2 8.2686 13.6979 3.8744 5.6001
Li-7 CTRP2 8.4327 10.4537 5.3732 0.4405
SNU-182 CTRP2 8.4353 17.74 2.0495 12.2412
SNU-449 CTRP2 8.6967 10.8611 5.3288 0.43
JHH-4 CTRP2 8.7621 13.4227 4.2983 3.4597
SNU-387 CTRP2 8.8999 17.2544 2.6033 9.5624
JHH-5 CTRP2 9.1138 10.6224 5.5645 0.0521
PLC/PRF/5 CTRP2 11.4926 18.8224 3.4213 3.9167
HLF CTRP2 13.6074 31.9013 -1.2557 15.2206
SNU-475 CTRP2 14.5502 36.5855 -2.8526 17.6975
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 140 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
EBC-1 CTRP2 -6.3873 -3.6094 -6.3874 81.7921
DMS 53 CTRP2 6.475 8.2319 5.2854 2.4489
NCI-H146 CTRP2 6.5855 18.2948 0.3641 20.9841
HOP-92 CTRP2 6.7001 9.8697 4.6469 4.7233
DV-90 CTRP2 6.7922 11.5145 3.9048 7.6398
NCI-H1385 CTRP2 6.8274 14.2736 2.5628 12.9787
NCI-H647 CTRP2 6.8468 8.9258 5.205 2.247
DMS 454 CTRP2 6.8768 10.9009 4.2701 5.9947
NCI-H211 CTRP2 6.9601 10.661 4.4476 5.1364
NCI-H1694 CTRP2 6.9729 8.8875 5.3019 1.7187
NCI-H1666 CTRP2 6.9773 12.6911 3.4629 9.1406
NCI-H1563 CTRP2 6.9974 13.3334 3.1605 10.3269
BEN CTRP2 6.998 8.1847 5.6257 0.5682
Calu-3 CTRP2 7.0091 10.4347 4.592 4.475
NCI-H810 CTRP2 7.0194 8.9133 5.318 1.6057
HCC2935 CTRP2 7.0521 13.8355 2.9534 11.0583
NCI-H1155 CTRP2 7.0789 10.1542 4.7746 3.6397
SW1271 CTRP2 7.0853 10.4026 4.6599 4.0906
NCI-H2106 CTRP2 7.1682 11.6724 4.1031 6.2245
DMS 114 CTRP2 7.191 9.6045 5.1049 2.2076
Calu-6 CTRP2 7.1918 9.3228 5.2339 1.7268
NCI-H1184 CTRP2 7.2064 14.6899 2.6477 11.9899
NCI-H446 CTRP2 7.2229 9.3775 5.2274 1.717
NCI-H1915 CTRP2 7.2704 12.5219 3.7618 7.4534
SK-LU-1 CTRP2 7.2885 9.8801 5.0375 2.348
NCI-H1573 CTRP2 7.2937 20.0008 0.0781 20.5195
NCI-H1355 CTRP2 7.2977 11.4394 4.3065 5.2088
HCC366 CTRP2 7.3454 10.6255 4.7261 3.4754
NCI-H2126 CTRP2 7.3508 8.9666 5.4749 0.7661
MOR/CPR CTRP2 7.3587 8.4092 5.6979 0.1976
NCI-H1650 CTRP2 7.3874 10.1233 4.9858 2.4282
NCI-H1651 CTRP2 7.3944 12.3055 3.9551 6.4835
NCI-H1734 CTRP2 7.402 11.1427 4.5185 4.2175
Lu-99 CTRP2 7.4091 9.1188 5.4404 0.8276
LK2 CTRP2 7.4122 8.2058 5.79 0.0539
SBC-5 CTRP2 7.4144 8.401 5.7227 0.1383
RERF-LC-Ad1 CTRP2 7.4203 8.3593 5.7397 0.1116
NCI-H1623 CTRP2 7.4317 12.5999 3.8385 6.8976
NCI-H322 CTRP2 7.4386 9.0835 5.4695 0.72
NCI-H2170 CTRP2 7.4466 9.8354 5.1506 1.7616
LC-1/sq-SF CTRP2 7.4684 8.8805 5.5648 0.4433
COLO 668 CTRP2 7.469 10.1349 5.029 2.1771
HCC1438 CTRP2 7.5015 16.6205 1.9162 14.2171
NCI-H2444 CTRP2 7.5097 8.7308 5.6397 0.3199
NCI-H1693 CTRP2 7.517 9.8432 5.1864 1.5675
NCI-H522 CTRP2 7.538 9.3653 5.4016 0.8508
NCI-H1944 CTRP2 7.5896 12.4614 4.0144 5.9627
Lu-65 CTRP2 7.6057 10.1681 5.0924 1.8089
NCI-H1568 CTRP2 7.6119 11.0364 4.7023 3.2364
NCI-H1341 CTRP2 7.6379 16.263 2.1947 12.976
NCI-H1838 CTRP2 7.665 9.6293 5.3546 0.9004
LXF 289 CTRP2 7.6863 11.0244 4.7532 2.9571
NCI-H1703 CTRP2 7.691 10.5101 4.9886 2.0906
NCI-H838 CTRP2 7.7217 11.5706 4.5226 3.7905
NCI-H460 CTRP2 7.7398 9.2453 5.5412 0.369
NCI-H650 CTRP2 7.7412 12.2183 4.2311 4.8979
NCI-H196 CTRP2 7.7476 12.0496 4.3149 4.5621
LOU-NH91 CTRP2 7.764 11.9362 4.3786 4.2935
NCI-H69 CTRP2 7.772 9.9416 5.2777 1.0544
HCC1588 CTRP2 7.789 11.2847 4.6959 3.0543
NCI-H1793 CTRP2 7.8119 14.3717 3.246 8.6858
ChaGo-K-1 CTRP2 7.8177 10.7867 4.9372 2.1458
NCI-H441 CTRP2 7.8342 10.4435 5.0965 1.5832
PC-14 CTRP2 7.8346 9.6342 5.4319 0.5813
RERF-LC-MS CTRP2 7.8425 19.9953 0.5049 18.3128
NCI-H292 CTRP2 7.8494 10.855 4.9247 2.1584
NCI-H2087 CTRP2 7.8529 14.8892 3.0235 9.4919
LCLC-103H CTRP2 7.8565 9.1763 5.6135 0.1913
NCI-H358 CTRP2 7.8631 11.3936 4.6905 2.9913
T3M-10 CTRP2 7.8668 10.4289 5.12 1.4778
NCI-H2029 CTRP2 7.8705 9.8324 5.3695 0.7237
NCI-H1581 CTRP2 7.8749 9.9406 5.3279 0.8355
Sq-1 CTRP2 7.8766 9.4535 5.5195 0.3585
NCI-H2122 CTRP2 7.9039 9.1783 5.6307 0.1535
NCI-H2009 CTRP2 7.9188 11.8761 4.5031 3.6281
NCI-H2228 CTRP2 7.9418 11.0555 4.8876 2.1977
NCI-H526 CTRP2 7.9554 9.3263 5.5975 0.1899
NCI-H889 CTRP2 7.9704 10.0536 5.327 0.7783
RERF-LC-Ad2 CTRP2 7.9714 10.5169 5.1365 1.3392
HOP-62 CTRP2 7.9732 17.7221 1.7247 14.1141
EKVX CTRP2 7.9892 15.9714 2.5935 10.9281
LUDLU-1 CTRP2 8.0132 9.8121 5.4408 0.4715
NCI-H2286 CTRP2 8.0171 9.8682 5.4209 0.5154
SHP-77 CTRP2 8.0326 9.5474 5.5475 0.2499
NCI-H226 CTRP2 8.0455 9.1762 5.6825 0.0695
COR-L88 CTRP2 8.0568 9.6874 5.5057 0.318
KNS-62 CTRP2 8.0656 10.0027 5.3899 0.5651
A-549 CTRP2 8.0894 11.0158 4.985 1.7305
IA-LM CTRP2 8.1339 9.5732 5.577 0.1761
COR-L95 CTRP2 8.1518 9.4031 5.6427 0.0926
NCI-H1435 CTRP2 8.2091 9.8425 5.5092 0.2622
DMS 79 CTRP2 8.2292 9.6684 5.5788 0.1526
VMRC-LCD CTRP2 8.2785 13.9664 3.7546 6.0482
NCI-H2110 CTRP2 8.2865 14.6815 3.4211 7.324
NCI-H2172 CTRP2 8.3163 9.665 5.6114 0.0998
NCI-H2085 CTRP2 8.3224 10.4003 5.3473 0.5425
COR-L105 CTRP2 8.3321 10.4886 5.3175 0.6066
NCI-H1792 CTRP2 8.3535 15.6661 2.9953 8.8638
SK-MES-1 CTRP2 8.3541 14.3161 3.6386 6.3959
HCC95 CTRP2 8.3564 9.6933 5.6159 0.0897
NCI-H2196 CTRP2 8.3579 16.0713 2.8034 9.5845
HARA [Human squamous cell lung carcinoma] CTRP2 8.3854 10.1339 5.4721 0.2727
NCI-H1105 CTRP2 8.3859 9.7782 5.5974 0.1036
HCC78 CTRP2 8.3933 10.7236 5.2529 0.7322
NCI-H2081 CTRP2 8.4099 10.4185 5.377 0.4416
NCI-H23 CTRP2 8.4179 21.3596 0.2636 18.0851
NCI-H661 CTRP2 8.4343 10.4589 5.3719 0.4425
NCI-H520 CTRP2 8.4437 10.0434 5.5264 0.1765
HCC1833 CTRP2 8.4774 10.593 5.3393 0.4931
NCI-H1395 CTRP2 8.4782 11.5522 4.9569 1.5077
CAL-12T CTRP2 8.4923 10.0558 5.5398 0.1496
HCC15 CTRP2 8.511 16.8463 2.5352 10.3635
NCI-H2342 CTRP2 8.5204 15.7432 3.0709 8.3429
NCI-H1299 CTRP2 8.5369 10.4862 5.4031 0.3457
LC-1F CTRP2 8.5496 37.3191 -7.5573 32.1883
HCC44 CTRP2 8.6424 17.6489 2.2387 11.2538
EPLC-272H CTRP2 8.6762 19.1279 1.5451 13.6294
NCI-H1755 CTRP2 8.7285 10.5696 5.4467 0.2223
HCC827 CTRP2 8.7816 16.2622 2.997 8.2661
NCI-H727 CTRP2 8.8108 10.5096 5.4978 0.1419
NCI-H2405 CTRP2 9.0066 10.578 5.543 0.0751
NCI-H2030 CTRP2 9.2326 15.5965 3.5912 5.5046
LCLC-97TM1 CTRP2 9.2451 11.0564 5.4645 0.112
NCI-H2291 CTRP2 9.2547 19.7171 1.6632 12.3802
COLO 699 CTRP2 9.3908 17.8718 2.6328 8.8011
NCI-H1092 CTRP2 9.5459 24.288 -0.3495 18.0786
NCI-H1869 CTRP2 9.7596 16.932 3.2967 5.9746
HCC2279 CTRP2 9.815 20.6131 1.6121 11.7772
RERF-LC-A1 CTRP2 9.8216 16.9361 3.3315 5.7834
NCI-H1373 CTRP2 9.9094 16.4098 3.6181 4.6899
NCI-H1339 CTRP2 10.0845 18.0957 2.9601 6.8001
HCC2108 CTRP2 10.1268 23.4348 0.4713 14.9303
HCC4006 CTRP2 10.535 21.8557 1.4946 11.2242
HCC1195 CTRP2 10.6624 20.5169 2.1988 8.7512
NCI-H2023 CTRP2 10.956 22.9733 1.2394 11.5097
HCC1171 CTRP2 10.9914 23.2953 1.1109 11.8648
Calu-1 CTRP2 11.6811 22.4842 1.9114 8.5505
DMS 273 CTRP2 12.3466 25.7353 0.8238 11.1371
NCI-H841 CTRP2 12.509 25.1131 1.2069 9.8324
Hs 888.Lu CTRP2 10.8985 20.8797 2.1757 8.5567
⏷ Show the Full List of 140 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Aska-SS CTRP2 -0.5666 5.6133 -1.0574 44.8269
Yamato-SS CTRP2 -0.2322 13.0784 -3.4811 45.5034
Tm87-16 CTRP2 5.5623 25.6465 -4.1612 32.5293
TE 441.T CTRP2 6.1231 9.2651 4.4992 6.3445
A-204 CTRP2 6.595 11.0884 3.9653 7.726
BT-12 CTRP2 6.8818 7.6332 5.7929 0.1889
GCT CTRP2 6.9838 13.4383 3.0982 10.5995
BT-16 CTRP2 7.1897 8.8871 5.4258 1.0532
MES-SA CTRP2 7.6938 8.9344 5.638 0.1973
RKN CTRP2 7.83 8.8789 5.7078 0.0747
TTC-709 CTRP2 7.9138 9.58 5.4872 0.4122
G-401 CTRP2 7.928 13.0434 3.9627 5.7014
SW982 CTRP2 7.9749 23.4514 -1.1072 22.4801
TE 617.T CTRP2 8.0672 9.741 5.4901 0.3447
G-402 CTRP2 8.0682 13.6514 3.7664 6.2801
Rh41 CTRP2 8.2966 13.68 3.9006 5.4642
SK-UT-1 CTRP2 8.646 14.9701 3.5186 6.478
RD CTRP2 8.7928 11.6074 5.0836 0.9443
KYM-1 CTRP2 9.4777 22.1741 0.6307 15.3713
HT-1080 CTRP2 10.2051 19.2356 2.5094 8.2302
Rh18 CTRP2 10.6068 20.5466 2.1509 8.9766
Hs 729.T CTRP2 12.2109 23.3194 1.8438 8.2083
SK-LMS-1 CTRP2 12.9851 28.2673 0.0468 12.6088
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
H-STS CTRP2 6.7787 9.9401 4.6694 4.5068
P-STS CTRP2 7.3279 10.5287 4.7604 3.364
SYO-1 CTRP2 14.1291 34.1309 -1.9684 16.2822
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 7.6514 12.5715 4.0035 5.919
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 10.833 31.2846 -2.8416 22.0783
OV56 CTRP2 6.5205 14.2195 2.3465 14.3696
Caov-3 CTRP2 6.5696 7.85 5.5327 1.3231
A2780 CTRP2 6.6834 9.1579 4.9827 3.3699
HEY A8 CTRP2 6.8417 8.2584 5.5101 1.0951
COV434 CTRP2 6.877 10.4066 4.5122 4.9995
SNU-119 CTRP2 7.0318 12.1448 3.7728 7.7873
TYK-nu CTRP2 7.0496 8.6229 5.4651 1.0479
COV362 CTRP2 7.1554 8.9066 5.3987 1.1768
TOV-112D CTRP2 7.3957 10.5166 4.8091 3.0902
SNU-8 CTRP2 7.4185 8.6834 5.6195 0.3372
Kuramochi CTRP2 7.4204 11.1366 4.5334 4.1338
FU-OV-1 CTRP2 7.5468 9.5168 5.3427 1.0248
SNU-840 CTRP2 7.5633 11.0078 4.6854 3.3599
OC 314 CTRP2 7.6009 9.09 5.5414 0.4327
MCAS CTRP2 7.6018 9.2971 5.46 0.6412
OVISE CTRP2 7.6918 8.8995 5.6498 0.1784
OAW42 CTRP2 7.6937 9.2172 5.5324 0.4094
TOV-21G CTRP2 7.7965 9.3414 5.5285 0.3725
ES2 CTRP2 7.8645 8.7917 5.7491 0.0374
OVCAR-8 CTRP2 7.8685 9.9179 5.3341 0.8222
COV644 CTRP2 7.8859 9.7331 5.4159 0.5939
OVCAR-4 CTRP2 7.8879 10.1486 5.2489 1.0565
ONCO-DG-1 CTRP2 7.9052 9.5316 5.502 0.3839
SK-OV-3 CTRP2 7.9131 9.7246 5.4313 0.5418
OVK18 CTRP2 7.9201 9.6353 5.4688 0.4504
JHOC-5 CTRP2 7.9681 10.5536 5.1193 1.3966
EFO-21 CTRP2 8.0298 11.319 4.8202 2.348
DOV13 CTRP2 8.0492 9.6605 5.5126 0.3076
OVCAR-5 CTRP2 8.1201 13.3903 3.9238 5.6003
OV7 CTRP2 8.1221 13.3213 3.9575 5.4675
JHOM-1 CTRP2 8.2083 9.4688 5.6402 0.0869
EFO-27 CTRP2 8.2492 10.3288 5.3434 0.5857
JHOS-2 CTRP2 8.2637 11.8245 4.7271 2.4457
RMG-I CTRP2 8.2741 10.677 5.2174 0.8916
OV-90 CTRP2 8.3048 14.7949 3.3793 7.4604
IGROV-1 CTRP2 8.3696 10.3433 5.3887 0.4334
OVTOKO CTRP2 8.7403 14.2211 3.9245 4.8415
OAW28 CTRP2 8.9897 10.844 5.4467 0.1689
OVSAHO CTRP2 10.8404 20.6078 2.2652 8.3251
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2452 CTRP2 6.7889 9.8523 4.7196 4.2855
MPP 89 CTRP2 7.7077 9.7314 5.3333 0.9334
JL-1 CTRP2 8.2203 13.7044 3.8404 5.7929
ACC-MESO-1 CTRP2 8.3273 10.0137 5.493 0.2547
MSTO-211H CTRP2 8.3928 10.4368 5.363 0.4776
IST-Mes1 CTRP2 8.4325 11.5661 4.9281 1.6319
NCI-H2052 CTRP2 8.552 10.081 5.5527 0.1245
NCI-H28 CTRP2 8.6355 19.787 1.1946 14.8572
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC CTRP2 7.4494 11.0695 4.584 3.8967
22Rv1 CTRP2 7.4895 10.2499 4.9889 2.302
PaCa-3 CTRP2 8.0297 9.1581 5.6831 0.0709
DU145 CTRP2 8.6333 14.9792 3.5063 6.5409
VCaP CTRP2 8.9944 18.8239 1.9147 11.89
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-15 CTRP2 8.008 12.7735 4.1417 4.9011
A-253 CTRP2 8.3229 10.4213 5.3395 0.56
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-620 CTRP2 -4.0652 -2.6938 -4.0652 67.3502
Hs 746.T CTRP2 -0.3036 36.2864 -14.6457 48.2924
IM95 CTRP2 2.788 13.3298 -0.5723 32.1632
NCC-StC-K140 CTRP2 5.6351 19.0871 -0.8211 26.0643
SNU-216 CTRP2 6.6106 9.2555 4.8828 3.8926
MKN45 CTRP2 6.6618 21.6296 -1.2398 25.0865
SNU-16 CTRP2 6.7342 9.0359 5.0772 2.9111
GSS CTRP2 6.7725 8.0463 5.5653 0.9681
GSU CTRP2 6.9185 7.7753 5.7539 0.2625
HGC-27 CTRP2 7.0965 9.5007 5.0946 2.3599
NCI-N87 CTRP2 7.2154 11.0777 4.4241 4.8534
MKN1 CTRP2 7.3573 11.2091 4.4573 4.521
NUGC-3 CTRP2 7.4532 9.2497 5.4078 0.8947
ECC12 CTRP2 7.56 8.4775 5.7494 0.0729
SH-10-TC CTRP2 7.7739 9.2182 5.5655 0.3045
SNU-1 CTRP2 7.8633 12.92 3.9787 5.7257
23132/87 CTRP2 7.8951 9.4149 5.5415 0.3069
AGS CTRP2 7.9505 9.6515 5.4755 0.4219
HuG1-N CTRP2 8.0581 10.1152 5.3425 0.6867
SNU-719 CTRP2 8.1746 10.2654 5.3354 0.6421
MKN7 CTRP2 8.2805 13.5593 3.9469 5.3075
Fu97 CTRP2 8.3176 9.8237 5.5569 0.1628
SNU-601 CTRP2 8.3294 10.2917 5.3915 0.4436
ECC10 CTRP2 8.3662 9.873 5.5575 0.1521
KATO III CTRP2 8.3716 10.0174 5.5086 0.2184
KE-39 CTRP2 8.7552 16.2253 2.9971 8.3011
MKN74 CTRP2 8.8921 10.7065 5.459 0.1722
LMSU CTRP2 9.8886 16.4751 3.5773 4.8519
NUGC-4 CTRP2 10.0184 28.0628 -1.8542 21.1022
SNU-668 CTRP2 10.397 18.3014 3.0508 6.1453
SNG-M CTRP2 7.5198 9.5151 5.3296 1.0877
SNU-1077 CTRP2 7.8337 11.1691 4.775 2.7128
SNU-685 CTRP2 8.0262 12.4306 4.3129 4.2217
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ML-1 [Human leukemia] CTRP2 7.0064 10.1941 4.7062 4.0167
B-CPAP CTRP2 7.1244 9.9746 4.89 3.1205
BHT-101 CTRP2 7.3864 9.9465 5.0659 2.1318
CAL-62 CTRP2 7.3892 8.8396 5.5451 0.539
CGTH-W-1 CTRP2 7.5946 11.8346 4.3169 4.7554
FTC-133 CTRP2 7.9788 9.4134 5.5752 0.2192
8505C CTRP2 8.0039 13.3538 3.8654 5.9804
8305C CTRP2 8.0467 11.6581 4.6785 2.8366
TT2609-C02 CTRP2 8.5106 10.4367 5.4109 0.3403
TT CTRP2 10.1056 18.9753 2.5685 8.1435
SW579 CTRP2 12.0879 22.4661 2.1553 7.3605
FTC-238 CTRP2 12.6676 26.7682 0.5441 11.5848
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
FaDu CTRP2 6.565 9.6131 4.6732 4.8333
SCC-25 CTRP2 6.6916 9.5413 4.8016 4.0993
HSC-4 CTRP2 6.7097 8.7757 5.1855 2.5102
CAL-33 CTRP2 7.1969 9.4473 5.1804 1.918
YD-10B CTRP2 7.2204 10.6855 4.6156 4.0787
HSC-3 CTRP2 7.3339 11.4977 4.3032 5.1703
PE/CA-PJ15 CTRP2 7.6966 10.1251 5.1608 1.49
BICR 6 CTRP2 7.7588 8.7505 5.7265 0.0666
BHY CTRP2 7.7905 10.4091 5.0881 1.6503
Detroit 562 CTRP2 7.8607 17.3464 1.8264 13.9394
BICR 56 CTRP2 7.8732 9.3602 5.553 0.2926
SNU-899 CTRP2 7.8805 13.0277 3.9389 5.8585
SCC-9 CTRP2 7.933 10.1548 5.2682 0.9678
BICR 16 CTRP2 7.9408 9.8184 5.4069 0.5873
BICR 22 CTRP2 7.9992 9.1574 5.6726 0.085
PE/CA-PJ41 (clone D2) CTRP2 8.0556 9.7822 5.4699 0.3901
BICR 31 CTRP2 8.1731 9.7171 5.5405 0.221
CAL-27 CTRP2 8.2499 12.6149 4.3645 3.7669
SNU-1041 CTRP2 8.2812 12.3936 4.4833 3.2958
BICR 18 CTRP2 8.289 10.2331 5.3968 0.4488
SNU-1066 CTRP2 8.3134 13.3699 4.0556 4.8526
PE/CA-PJ34 (clone C12) CTRP2 8.4493 10.3698 5.4111 0.3604
PE/CA-PJ49 CTRP2 8.5482 9.8185 5.6399 0.0503
SNU-1214 CTRP2 8.5586 11.2636 5.1137 1.0004
YD-8 CTRP2 9.0205 16.9837 2.8117 8.6346
SNU-46 CTRP2 9.6428 24.2421 -0.2578 17.6882
HSC-2 CTRP2 10.2546 18.9873 2.6542 7.672
SNU-1076 CTRP2 11.8729 23.1957 1.7016 9.0051
SCC-4 CTRP2 12.5089 36.4654 -4.1735 22.4747
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HT-1197 CTRP2 6.6666 10.473 4.3248 12.8252
RT-4 CTRP2 7.1342 10.2828 4.7502 3.6611
TCCSUP CTRP2 7.156 12.1834 3.8447 7.2955
639V CTRP2 7.2047 8.3153 5.6692 0.3231
253J CTRP2 7.3633 8.9367 5.4935 0.7019
SW1710 CTRP2 7.3722 9.4828 5.265 1.433
HT-1376 CTRP2 7.3881 11.8142 4.188 5.5551
JMSU-1 CTRP2 7.493 10.625 4.8192 2.9337
KU-19-19 CTRP2 7.6752 9.1012 5.5688 0.337
647V CTRP2 7.7244 10.2163 5.1362 1.5476
5637 CTRP2 7.7692 13.0407 3.8583 6.3298
CAL-29 CTRP2 7.7702 9.2978 5.534 0.3717
BC-3C CTRP2 7.8157 9.7686 5.3697 0.7566
RT-112 CTRP2 7.8231 9.3188 5.548 0.3209
T24 CTRP2 7.948 10.1662 5.2708 0.9502
KMBC-2 CTRP2 7.9862 10.998 4.9374 1.9829
J82 CTRP2 8.1199 10.772 5.1042 1.3251
SCaBER CTRP2 8.1851 10.1147 5.3981 0.4901
UM-UC-1 CTRP2 8.557 10.6092 5.3659 0.4085
U-BLC1 CTRP2 9.1021 18.7348 2.0311 11.3304
VM-CUB-1 CTRP2 9.3576 14.5895 4.1148 3.5164
UM-UC-3 CTRP2 9.5664 18.0935 2.6411 8.5471
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 7.131 8.2517 5.6614 0.3815

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5709).
2 CenterWatch. Drugs in Clinical Trials Database. CenterWatch. 2008.
3 Species-specific metabolism of SGX523 by aldehyde oxidase and the toxicological implications. Drug Metab Dispos. 2010 Aug;38(8):1277-85.