Details of the Drug

General Information of Drug (ID: DM449LS)

Drug Name

MI-3

Synonyms

MI-3; MI-3 (Menin-MLL Inhibitor); 4-(4-(5,5-Dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-isopropylthieno[2,3-d]pyrimidine; GTPL8103; CHEMBL3696180; SCHEMBL12789955; MolPort-035-789-713; BDBM152232; BCP11052; EX-A2098; s7619; ZINC95641929; AKOS030526376; CS-0772; SB19342; NCGC00386410-02; HY-15223; BC600609; US8993552, 67; 1-(5,5-dimethyl-4,5-dihydro-1,3-thiazol-2-yl)-4-[6-(propan-2-yl)thieno[2,3-d]pyrimidin-4-yl]piperazine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]
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Drug Type

Small molecular drug

Structure

3D MOL is unavailable

2D MOL

Chemical Identifiers

Formula: C18H25N5S2
Canonical SMILES: CC(C)C1=CC2=C(N=CN=C2S1)N3CCN(CC3)C4=NCC(S4)(C)C
InChI: 1S/C18H25N5S2/c1-12(2)14-9-13-15(20-11-21-16(13)24-14)22-5-7-23(8-6-22)17-19-10-18(3,4)25-17/h9,11-12H,5-8,10H2,1-4H3
InChIKey: FUGQNAUKABUDQI-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 51001299
TTD ID: D00SCI

References

1	Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia. Nat Chem Biol. 2012 Jan 29;8(3):277-84.