Details of the Drug

General Information of Drug (ID: )

• #Ro5 Violations (Lipinski): 1:
  Molecular Weight (mw)
  Logarithm of the Partition Coefficient (xlogp)
  Rotatable Bond Count (rotbonds)
  Hydrogen Bond Donor Count (hbonddonor)
  Hydrogen Bond Acceptor Count (hbondacc)
• ADMET Property:
  Absorption AUC: The area under the plot of plasma concentration (AUC) of drug is 1585 mcgh/L [1]
  Absorption Cmax: The maximum plasma concentration (Cmax) of drug is 2229 mcg/L [1]
  Absorption Tmax: The time to maximum plasma concentration (Tmax) is 0.67-0.68 h [1]
  Elimination: Remdesivir is 74% eliminated in the urine and 18% eliminated in the feces [2]
  Half-life: The concentration or amount of drug in body reduced by one-half in 1 hour [1]
  Metabolism: The drug is metabolized via the cyclization to eject the phenoxide moiety and finally hydrolysis of the cyclic anhydride to yield the detectable alanine metabolite (GS-704277) [3]

References

• [1] FDA Approved Drug Products: VEKLURY (remdesivir) injection
• [2] FDA: Fact Sheet For Health Care Providers EUA of Remdesivir
• [3] Wang Z, Lee B, Pearce D, Qian S, Wang Y, Zhang Q, Chow MS: Meclizine metabolism and pharmacokinetics: formulation on its absorption. J Clin Pharmacol. 2012 Sep;52(9):1343-9. doi: 10.1177/0091270011414575. Epub 2011 Sep 8.