Details of the Drug

General Information of Drug (ID: DM4CNSS)

Drug Name

GNF-2

Synonyms

GNF 2

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]
------------------------------------------------------------------------------------

Drug Type

Small molecular drug

Structure

3D MOL is unavailable

2D MOL

Chemical Identifiers

Formula: C18H13F3N4O2
Canonical SMILES: C1=CC(=CC(=C1)C(=O)N)C2=CC(=NC=N2)NC3=CC=C(C=C3)OC(F)(F)F
InChI: 1S/C18H13F3N4O2/c19-18(20,21)27-14-6-4-13(5-7-14)25-16-9-15(23-10-24-16)11-2-1-3-12(8-11)17(22)26/h1-10H,(H2,22,26)(H,23,24,25)
InChIKey: WEVYNIUIFUYDGI-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 5311510
ChEBI ID: CHEBI:91337
CAS Number: 778270-11-4
TTD ID: D05UJT

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 142 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
JM1	GDSC1	2.2857	4.1242	-0.2645	0.9936
ALL-SIL	GDSC1	-2.8983	-0.8996	-2.9478	40.9324
LAMA-84	GDSC1	-2.774	-0.5031	-2.8695	39.6215
BV-173	GDSC1	-2.6042	1.1604	-3.1251	39.4049
EM-2	GDSC1	-2.3934	1.4822	-3.0129	37.4835
KCL-22	GDSC1	-1.9932	-0.7349	-2.0119	29.4842
K-562	GDSC1	-1.3512	0.6332	-1.5895	22.9189
SUP-B15	GDSC1	-0.4241	5.7553	-3.0184	26.9811
MEG-01	GDSC1	1.0387	6.1095	-1.9734	15.3816
SU-DHL-8	GDSC1	1.1954	3.1116	-0.4008	3.5267
SUP-T1	GDSC1	1.2421	3.9249	-0.7548	6.014
ST486	GDSC1	1.2944	4.0569	-0.7828	6.0862
YT	GDSC1	1.3307	4.751	-1.0916	8.2734
GA-10	GDSC1	1.348	3.243	-0.3684	2.9654
RL	GDSC1	1.4286	3.1986	-0.3021	2.3598
SKM-1	GDSC1	1.4935	6.1813	-1.6716	11.9477
Raji	GDSC1	1.5317	3.0466	-0.1817	1.4394
HL-60	GDSC1	1.5331	2.7986	-0.0792	0.8772
MC116	GDSC1	1.5336	2.5967	0	0.5086
A3/Kawakami	GDSC1	1.5627	4.3026	-0.7251	5.0104
P32/ISH	GDSC1	1.6115	2.8657	-0.0703	0.7504
BC-1	GDSC1	1.6637	3.4824	-0.2987	1.938
Jiyoye	GDSC1	1.6644	3.9359	-0.4968	3.2097
SR	GDSC1	1.73	3.3415	-0.2065	1.31
JJN-3	GDSC1	1.7477	7.1906	-1.9823	13.2804
NOMO-1	GDSC1	1.7543	4.0112	-0.4797	2.9287
SU-DHL-4	GDSC1	1.7824	3.2411	-0.1417	0.9158
AMO1	GDSC1	1.7928	3.3073	-0.1632	1.0104
BE-13	GDSC1	1.814	6.7295	-1.7126	11.3255
IM-9	GDSC1	1.8173	4.2955	-0.5703	3.408
SIG-M5	GDSC1	1.8344	2.6956	0.08	0.1115
KOPN-8	GDSC1	1.8353	3.4966	-0.2196	1.2497
697	GDSC1	1.8397	3.227	-0.1109	0.7191
KG-1	GDSC1	1.8547	3.7805	-0.3273	1.8216
SUP-M2	GDSC1	1.8709	2.9312	0.0113	0.256
L-363	GDSC1	1.8887	4.1471	-0.466	2.6078
Ramos.2G6.4C10	GDSC1	1.8895	3.4603	-0.1801	0.9895
Farage	GDSC1	1.891	3.5774	-0.2261	1.2178
NB4	GDSC1	1.9105	2.9161	0.0313	0.1885
MY-M12	GDSC1	1.918	7.8236	-2.1696	13.98
OCI-AML-5	GDSC1	1.9367	7.3374	-1.9212	12.3625
WSU-DLCL2	GDSC1	1.9404	3.0959	-0.0212	0.3155
ML-2	GDSC1	1.9578	4.0567	-0.3914	2.0463
Karpas-231	GDSC1	1.9831	3.1216	-0.0141	0.2744
OPM-2	GDSC1	2.0222	3.3848	-0.0945	0.5109
DoHH2	GDSC1	2.0231	3.2576	-0.0476	0.3524
Loucy	GDSC1	2.0252	3.5883	-0.1702	0.8129
NK-92MI	GDSC1	2.045	3.9158	-0.2907	1.372
SCC-3	GDSC1	2.0716	3.4597	-0.1023	0.506
THP-1	GDSC1	2.0756	3.5845	-0.1474	0.6749
SU-DHL-1	GDSC1	2.0795	3.2102	-0.0095	0.2221
KE-37	GDSC1	2.0797	3.2575	-0.026	0.2636
BL-41	GDSC1	2.0851	12.307	-4.2467	23.7271
DB	GDSC1	2.0863	4.3934	-0.4681	2.309
Karpas-422	GDSC1	2.088	4.2314	-0.3993	1.9079
SK-MM-2	GDSC1	2.1032	4.7374	-0.6069	3.1329
CCRF-CEM	GDSC1	2.1084	4.217	-0.3833	1.7908
ME1	GDSC1	2.1244	3.3466	-0.0409	0.2837
OCI-M1	GDSC1	2.1254	3.2292	0.0006	0.1828
HT	GDSC1	2.1406	3.3345	-0.0306	0.2499
JVM-3	GDSC1	2.142	4.4148	-0.449	2.1162
HEL	GDSC1	2.1675	3.3704	-0.0332	0.2458
U266B1	GDSC1	2.1756	4.3431	-0.4027	1.8094
A4/Fukuda	GDSC1	2.1777	3.6925	-0.1458	0.5928
EJM	GDSC1	2.1823	4.1892	-0.3368	1.4499
NU-DUL-1	GDSC1	2.1898	3.5867	-0.1021	0.4323
GDM-1	GDSC1	2.2181	4.6967	-0.5291	2.4735
P31/FUJ	GDSC1	2.2441	3.4656	-0.0384	0.229
L-1236	GDSC1	2.2554	4.8565	-0.5778	2.7072
OCI-AML-3	GDSC1	2.2597	3.3732	-0.001	0.1463
MOLP-8	GDSC1	2.2728	3.639	-0.0889	0.3484
MOLT-4	GDSC1	2.2747	3.7315	-0.1215	0.4467
WIL2 NS	GDSC1	2.2756	3.5854	-0.0689	0.292
Karpas-299	GDSC1	2.2868	4.3431	-0.3502	1.399
BC-3	GDSC1	2.296	3.9101	-0.1788	0.6327
NALM-6	GDSC1	2.2998	4.3994	-0.3668	1.4682
SU-DHL-6	GDSC1	2.3291	3.7717	-0.115	0.3968
Namalwa	GDSC1	2.3352	3.8682	-0.1476	0.4969
DG-75	GDSC1	2.3511	4.1621	-0.251	0.8773
MHH-PREB-1	GDSC1	2.3531	5.045	-0.6076	2.7359
MOLM-13	GDSC1	2.3733	4.2876	-0.2897	1.0254
SU-DHL-16	GDSC1	2.3862	3.4973	0.0011	0.1131
PL-21	GDSC1	2.3929	5.2711	-0.6834	3.1302
Daudi	GDSC1	2.4062	3.8671	-0.1198	0.3723
BALL-1	GDSC1	2.4112	4.2528	-0.2602	0.8656
NKM-1	GDSC1	2.4126	4.8371	-0.4911	1.9871
L-428	GDSC1	2.4401	4.2156	-0.2341	0.7386
KMS-12-BM	GDSC1	2.4449	4.0712	-0.1786	0.5345
LP-1	GDSC1	2.4546	3.853	-0.0967	0.2889
HH [Human lymphoma]	GDSC1	2.458	4.8062	-0.4569	1.7483
RPMI-6666	GDSC1	2.4611	4.337	-0.2712	0.8702
Karpas-45	GDSC1	2.4737	4.6659	-0.3934	1.41
Reh	GDSC1	2.5088	8.6809	-2.1778	12.4681
ARH-77	GDSC1	2.5292	4.4552	-0.2874	0.8818
WSU-NHL	GDSC1	2.5502	4.2759	-0.212	0.5833
DND-41	GDSC1	2.5556	4.5366	-0.3073	0.9421
MOLT-16	GDSC1	2.5559	3.9251	-0.0849	0.225
OCI-AML-2	GDSC1	2.5708	3.7363	-0.0156	0.1012
RPMI-8226	GDSC1	2.6008	4.8051	-0.3914	1.2712
EB2	GDSC1	2.6179	4.3285	-0.2045	0.5187
Hs 445	GDSC1	2.6676	4.252	-0.1582	0.3582
CTV-1	GDSC1	2.6719	4.1326	-0.1148	0.2513
P30/OHK	GDSC1	2.7085	4.2118	-0.129	0.2703
RPMI-8402	GDSC1	2.7318	4.1967	-0.1154	0.233
RS4;11	GDSC1	2.7364	4.5597	-0.2423	0.5729
OCI-Ly19	GDSC1	2.7364	4.3657	-0.1726	0.3667
Kasumi-1	GDSC1	2.7521	4.5697	-0.2398	0.5558
HC-1	GDSC1	2.7653	4.7388	-0.2966	0.7428
MN-60	GDSC1	2.7805	5.0391	-0.4039	1.1607
U-698-M	GDSC1	2.7906	4.8577	-0.3307	0.8525
LC4-1	GDSC1	2.7935	4.7374	-0.2848	0.6819
HAL-01	GDSC1	2.803	4.7212	-0.2751	0.6425
TUR	GDSC1	2.8064	4.4553	-0.1782	0.3516
KMOE-2	GDSC1	2.8078	5.4904	-0.5695	1.9196
Karpas-620	GDSC1	2.8485	4.2518	-0.0929	0.1596
MV4-11	GDSC1	2.8721	4.2821	-0.095	0.1575
KY821	GDSC1	2.9077	4.2287	-0.0649	0.1071
EoL-1	GDSC1	3.0136	6.2097	-0.7647	2.701
CTB-1	GDSC1	3.027	5.2298	-0.3731	0.8436
MLMA	GDSC1	3.0426	4.6153	-0.1483	0.2073
QIMR-WIL	GDSC1	3.0428	5.1198	-0.3263	0.6694
CA46	GDSC1	3.0541	10.0987	-2.492	12.9644
Granta-519	GDSC1	3.0713	4.6156	-0.1384	0.1827
VL51	GDSC1	3.0736	4.7955	-0.1992	0.3008
KM-H2	GDSC1	3.0905	4.9931	-0.2623	0.4506
SUP-HD1	GDSC1	3.1373	5.1918	-0.3156	0.5823
L-540	GDSC1	3.1512	4.7196	-0.1457	0.1761
RPMI-8866	GDSC1	3.1612	4.8168	-0.1752	0.2249
CESS	GDSC1	3.1865	4.6468	-0.1092	0.1167
Ku812	GDSC1	3.2061	4.8198	-0.1605	0.1876
H9	GDSC1	3.2903	4.8359	-0.1369	0.1347
PF-382	GDSC1	3.3535	5.008	-0.1728	0.1742
ROS-50	GDSC1	3.3782	5.3373	-0.2768	0.3697
ALL-PO	GDSC1	3.4206	12.56	-3.4196	16.8223
GR-ST	GDSC1	3.5094	6.794	-0.7681	2.129
EHEB	GDSC1	3.5263	5.3037	-0.2126	0.1988
ATN-1	GDSC1	3.54	14.547	-4.2931	20.2351
Mono-Mac-6	GDSC1	3.5586	6.0159	-0.4505	0.7753
HDLM-2	GDSC1	3.6599	5.4644	-0.2204	0.1821
JVM-2	GDSC1	3.6772	5.5877	-0.2561	0.2359
JSC-1	GDSC1	3.8683	5.6308	-0.2049	0.125
DEL	GDSC1	6.3748	17.272	-3.7685	12.5622
-----------


⏷ Show the Full List of 142 Cancer Drug Sensitivity Data of This Drug

Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Aero Dig Tract Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
TE-12	GDSC1	2.2852	7.448	-1.7398	10.284
HCE-4	GDSC1	2.9023	4.5993	-0.1934	0.3508
-----------

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
COLO 684	GDSC1	1.8233	4.663	-0.7322	4.4909
-----------

Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Autonomic Ganglia Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
KP-N-YN	GDSC1	1.7006	4.4437	-0.7056	4.5663
SK-N-DZ	GDSC1	1.7122	3.3215	-0.2069	1.3351
KP-N-RT-BM-1	GDSC1	1.7124	4.7947	-0.8604	5.6291
SK-N-FI	GDSC1	1.764	3.5646	-0.2823	1.6905
SJNB-6	GDSC1	1.8029	3.4278	-0.207	1.2225
IMR-5	GDSC1	1.9668	3.7931	-0.2778	1.3981
SK-N-BE(2)-M17	GDSC1	2.193	4.074	-0.2859	1.184
SJNB-13	GDSC1	2.248	4.0139	-0.2382	0.9117
TGW	GDSC1	2.2547	3.4967	-0.0454	0.2416
SJNB-14	GDSC1	2.2785	3.7157	-0.1143	0.4216
SJNB-10	GDSC1	2.2902	4.3699	-0.3594	1.4415
Kelly	GDSC1	2.3881	3.8219	-0.1105	0.3546
SJNB-7	GDSC1	2.4194	4.0103	-0.1664	0.509
CHP-126	GDSC1	2.445	3.9319	-0.1282	0.3776
NH-12	GDSC1	2.4761	4.0829	-0.1706	0.4901
NB(TU)1	GDSC1	2.6122	4.1029	-0.1262	0.2996
MHH-NB-11	GDSC1	2.6375	4.4351	-0.2357	0.6104
SJNB-17	GDSC1	2.7373	4.6966	-0.2923	0.746
GOTO	GDSC1	2.8306	5.343	-0.5003	1.5526
SiMa	GDSC1	2.851	5.0644	-0.3836	1.0157
LA-N-6	GDSC1	2.9016	4.7876	-0.2607	0.5392
KP-N-YS	GDSC1	3.0068	5.1265	-0.343	0.7488
NB69	GDSC1	3.1423	4.891	-0.2074	0.2958
GI-ME-N	GDSC1	3.2991	6.2449	-0.6458	1.7643
SJNB-5	GDSC1	3.4138	5.04	-0.1628	0.1474
NB1	GDSC1	4.2463	12.1123	-2.6833	11.4206
-----------


⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug

Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Bone Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
NOS-1 [Human HNSCC]	GDSC1	-0.0317	32.1478	-15.8641	43.9025
ES6	GDSC1	0.4082	60.1129	-29.4789	46.2856
ES4	GDSC1	1.274	3.2834	-0.4317	3.5695
ES7	GDSC1	1.8642	6.9481	-1.7835	11.6608
ES1	GDSC1	2.1341	4.3692	-0.4339	2.0404
EW-24	GDSC1	2.2886	3.4085	-0.0029	0.1422
SJSA-1	GDSC1	2.3211	3.8778	-0.1567	0.5364
EW-12	GDSC1	2.3477	4.7752	-0.4972	2.1061
SK-ES-1	GDSC1	2.6538	4.1219	-0.1176	0.2639
ES8	GDSC1	2.706	4.3023	-0.1616	0.3509
EW-1	GDSC1	2.7772	5.1304	-0.4406	1.3271
TC-71	GDSC1	2.8161	4.1967	-0.0856	0.1551
EW-13	GDSC1	2.9952	4.7311	-0.2053	0.3437
ES5	GDSC1	3.087	6.0677	-0.6719	2.1198
EW-11	GDSC1	3.2491	5.8549	-0.5165	1.238
SK-PN-DW	GDSC1	3.4204	5.3287	-0.2585	0.3141
H-EMC-SS	GDSC1	3.461	5.5641	-0.3258	0.4579
EW-16	GDSC1	3.4865	5.7019	-0.3651	0.5527
EW-18	GDSC1	3.5815	5.6447	-0.3097	0.3723
EW-3	GDSC1	3.8757	5.7705	-0.2488	0.1804
-----------


⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug

Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Breast Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
DU4475	GDSC1	1.595	2.9379	-0.1065	0.9454
OCUB-M	GDSC1	1.9164	3.9837	-0.3816	2.0498
MRK-nu-1	GDSC1	1.9556	4.8777	-0.7518	4.3545
Evsa-T	GDSC1	2.0504	3.6338	-0.1769	0.8197
CAL-148	GDSC1	2.1156	3.7499	-0.1935	0.8343
BT-474	GDSC1	2.165	3.335	-0.0218	0.2192
HCC1599	GDSC1	2.4022	4.2118	-0.2484	0.8244
HCC1187	GDSC1	2.4598	6.4841	-1.1829	6.2136
HCC2157	GDSC1	2.6082	4.0165	-0.0976	0.2352
HCC2218	GDSC1	2.6875	10.4719	-2.9153	16.1453
MFM-223	GDSC1	2.8232	4.4628	-0.1747	0.3358
COLO 824	GDSC1	2.9768	5.5788	-0.5277	1.5345
-----------


⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug

Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Central Nervous System Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
Onda 10	GDSC1	0.794	31.4506	-14.8277	42.1668
GI-1	GDSC1	1.0216	10.5466	-4.1957	26.6755
D-336MG	GDSC1	1.152	7.2144	-2.4344	17.8945
NMC-G1	GDSC1	1.6833	2.9885	-0.0866	0.7553
D283 Med	GDSC1	1.7459	4.8834	-0.8807	5.6959
U-87MG ATCC	GDSC1	2.0442	3.5798	-0.1588	0.7474
GB-1	GDSC1	2.1087	18.1245	-7.1131	31.6291
CAS-1	GDSC1	2.1876	4.1692	-0.3263	1.39
KNS-81-FD	GDSC1	2.2072	4.2319	-0.3424	1.4497
KINGS-1	GDSC1	2.2909	11.571	-3.732	21.0761
Becker	GDSC1	2.3836	4.21	-0.2555	0.869
AM-38	GDSC1	2.4049	4.2025	-0.2437	0.8033
KNS-42	GDSC1	2.4237	3.9308	-0.1359	0.4107
SF539	GDSC1	2.5546	4.0326	-0.1228	0.3142
D-263MG	GDSC1	2.5813	4.176	-0.1637	0.4133
8-MG-BA	GDSC1	3.1412	4.6646	-0.1306	0.1547
D-247MG	GDSC1	3.1962	4.8716	-0.1815	0.2271
SF268	GDSC1	3.2097	5.2229	-0.2991	0.4975
ONS-76	GDSC1	3.2457	4.6124	-0.078	0.0744
SNB-75	GDSC1	3.2492	24.1464	-9.2223	32.8562
Onda 11	GDSC1	3.3728	5.5682	-0.3605	0.5953
KS-1 [Human Krukenberg tumour]	GDSC1	3.4081	5.8671	-0.4556	0.8855
KALS-1	GDSC1	3.4339	7.0781	-0.9183	2.9855
D-502MG	GDSC1	3.5785	5.4923	-0.2583	0.266
SF126	GDSC1	8.0671	24.8371	-6.2108	18.162
-----------


⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug

Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
TGBC1TKB	GDSC1	0.7318	2.6447	-0.4922	5.4461
TGBC24TKB	GDSC1	2.4624	4.9084	-0.4964	1.9525
ETK-1	GDSC1	2.6822	30.4061	-12.7771	37.8178
-----------

Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Endometrium Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
RL95-2	GDSC1	0.8728	5.3899	-1.7441	14.3803
KLE	GDSC1	3.051	4.8736	-0.2348	0.3948
-----------

Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Kidney Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
LB2241-RCC	GDSC1	0.8973	6.4098	-2.2324	17.5123
A-704	GDSC1	1.491	3.3262	-0.3238	2.3879
LB1047-RCC	GDSC1	1.5886	11.2794	-4.1154	24.6382
LB996-RCC	GDSC1	2.5456	5.7957	-0.8286	3.7729
BB65-RCC	GDSC1	2.6796	4.7769	-0.3464	1.0024
A-498	GDSC1	2.6943	15.2245	-5.2308	25.5089
OS-RC-2	GDSC1	3.1464	5.1699	-0.3042	0.5432
RXF 393L	GDSC1	3.3225	6.0247	-0.5502	1.3176
HA7-RCC	GDSC1	3.3279	11.6827	-3.0631	15.3302
TK-10	GDSC1	3.3608	6.0421	-0.5407	1.2461
RCC10RGB	GDSC1	6.6567	22.2781	-5.9042	19.515
-----------


⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug

Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Large Intestine Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
LS411N	GDSC1	1.1905	6.4595	-2.0312	15.2702
COLO 320HSR	GDSC1	2.1825	4.7675	-0.5777	2.821
KM12	GDSC1	2.2161	3.8994	-0.208	0.8097
LS1034	GDSC1	2.3164	3.7532	-0.1132	0.3979
LS513	GDSC1	2.3554	4.3487	-0.3214	1.187
NCI-H747	GDSC1	2.3745	12.3284	-4.0425	22.1441
MDST8	GDSC1	2.4056	3.7246	-0.0697	0.243
SNU-C1	GDSC1	2.476	4.2517	-0.2328	0.7077
RKO	GDSC1	2.5937	4.1377	-0.1453	0.3564
LS123	GDSC1	2.6703	8.1101	-1.8037	9.7744
NCI-H716	GDSC1	2.6707	4.3524	-0.1927	0.4539
C2BBe1	GDSC1	2.6921	4.5698	-0.2635	0.6725
CL-11	GDSC1	3.0948	4.9426	-0.2428	0.3973
CW-2	GDSC1	3.3507	5.3215	-0.2813	0.3909
SNU-C2B	GDSC1	4.3812	6.6664	-0.3756	0.2683
-----------


⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
MO-T	GDSC1	2.291	3.9747	-0.2051	0.7376
-----------

Cancer Drug Sensitivity Data Curated from 63 Cell Line(s) in Lung Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
NCI-H1436	GDSC1	1.0078	2.597	-0.2789	3.0818
SBC-1	GDSC1	1.2294	7.4285	-2.4812	17.9207
NCI-H1355	GDSC1	1.4684	19.1522	-8.1318	34.9136
NCI-H1092	GDSC1	1.486	3.5205	-0.4131	2.9928
NCI-H345	GDSC1	1.5257	9.7451	-3.4028	21.805
LB647-SCLC	GDSC1	1.6191	8.036	-2.4888	16.7577
NCI-H720	GDSC1	1.6286	7.4128	-2.1761	14.8505
NCI-H526	GDSC1	1.6388	4.3027	-0.6783	4.5089
NCI-H64	GDSC1	1.649	2.9408	-0.0831	0.7729
NCI-H2196	GDSC1	1.687	4.8335	-0.8945	5.9302
NCI-H2171	GDSC1	1.7485	3.38	-0.2134	1.3239
SHP-77	GDSC1	1.7817	5.7365	-1.2589	8.2856
NCI-H2141	GDSC1	1.8063	3.7237	-0.3278	1.8954
NCI-H209	GDSC1	1.9117	5.7135	-1.1637	7.2986
NCI-H1694	GDSC1	1.9121	3.4564	-0.1684	0.911
DMS 79	GDSC1	1.9129	8.6774	-2.5892	16.473
NCI-H510A	GDSC1	1.9276	7.8428	-2.1722	13.9694
NCI-H1648	GDSC1	1.9349	5.7882	-1.1839	7.3843
NCI-H1304	GDSC1	2.049	3.4424	-0.105	0.531
NCI-H211	GDSC1	2.1229	4.802	-0.6244	3.2095
NCI-H1836	GDSC1	2.1613	3.4689	-0.0705	0.3499
Lu-139	GDSC1	2.1624	4.4512	-0.454	2.1164
Lu-65	GDSC1	2.1629	4.5409	-0.4914	2.3329
NCI-H1581	GDSC1	2.1769	3.6683	-0.1372	0.5613
IST-SL1	GDSC1	2.186	4.5505	-0.4838	2.2547
NCI-H1876	GDSC1	2.1986	4.273	-0.3631	1.5673
NCI-H1155	GDSC1	2.2022	3.7595	-0.1608	0.6318
NCI-H2081	GDSC1	2.207	4.1478	-0.3088	1.2809
NCI-H847	GDSC1	2.2191	3.5729	-0.0857	0.3656
Lu-165	GDSC1	2.245	4.7061	-0.5194	2.3767
NCI-H82	GDSC1	2.2538	3.7836	-0.1489	0.5522
NCI-H1770	GDSC1	2.2544	3.726	-0.1275	0.478
LC-2/ad	GDSC1	2.2886	11.1169	-3.5111	20.1034
NCI-H2135	GDSC1	2.2919	3.6472	-0.0847	0.3274
CPC-N	GDSC1	2.3382	4.4461	-0.3678	1.43
COR-L95	GDSC1	2.3534	3.7831	-0.1098	0.3692
NCI-H226	GDSC1	2.3735	4.037	-0.1946	0.637
Calu-6	GDSC1	2.3785	4.1694	-0.2422	0.8184
NCI-H1975	GDSC1	2.3957	4.0256	-0.1814	0.5748
IA-LM	GDSC1	2.4404	3.8644	-0.1059	0.3186
NCI-H187	GDSC1	2.4485	10.7883	-3.2357	18.3778
COR-L88	GDSC1	2.457	4.4449	-0.3143	1.0579
DMS 114	GDSC1	2.5311	4.2854	-0.223	0.6341
HCC33	GDSC1	2.6042	4.2968	-0.1983	0.5066
NCI-H524	GDSC1	2.6628	12.536	-3.9349	20.9478
HOP-62	GDSC1	2.6677	4.3987	-0.2106	0.5101
NCI-H1666	GDSC1	2.6777	4.7961	-0.3546	1.0383
NCI-H128	GDSC1	2.6832	10.8358	-3.0939	17.0652
NCI-H69	GDSC1	2.8466	4.8612	-0.3092	0.7336
NCI-H446	GDSC1	2.8737	4.5804	-0.1973	0.3727
NCI-H748	GDSC1	2.928	4.8399	-0.2694	0.5518
NCI-H1963	GDSC1	2.9537	5.8986	-0.666	2.2473
Ms-1	GDSC1	2.9823	4.5506	-0.1476	0.2224
EKVX	GDSC1	3.0271	5.7388	-0.5682	1.6746
COLO 668	GDSC1	3.103	4.8425	-0.2048	0.3033
NCI-H1838	GDSC1	3.1127	5.3478	-0.3822	0.8188
Lu-134-A	GDSC1	3.1539	5.1947	-0.3102	0.5574
NCI-H322M	GDSC1	3.1933	5.6841	-0.4751	1.1138
NCI-H23	GDSC1	3.4111	5.634	-0.3695	0.6025
LXF 289	GDSC1	3.5628	5.7166	-0.3417	0.4563
IST-SL2	GDSC1	3.7408	5.9304	-0.3511	0.4102
NCI-H1869	GDSC1	4.4852	13.224	-3.049	12.7693
NCI-H1650	GDSC1	5.8006	18.0815	-4.4845	16.342
-----------


⏷ Show the Full List of 63 Cancer Drug Sensitivity Data of This Drug

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
CBTCi002-A	GDSC1	2.6849	5.0319	-0.443	1.4289
-----------

Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Oesophagus Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
TE-6	GDSC1	1.9308	6.1446	-1.3545	8.5786
TE-9	GDSC1	2.1044	3.5306	-0.1154	0.5311
EC-GI-10	GDSC1	2.1564	3.9527	-0.2545	1.0716
TE-15	GDSC1	2.3731	6.2323	-1.1199	5.9753
TE-5	GDSC1	2.8324	4.3788	-0.1421	0.2571
TE-11	GDSC1	3.0936	10.5973	-2.7021	14.0192
TE-8	GDSC1	3.521	5.5423	-0.2961	0.3628
TE-1	GDSC1	4.4847	14.5577	-3.6695	15.6118
TE-10	GDSC1	4.9593	18.3999	-5.178	20.3501
-----------


⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug

Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Ovary Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
OVCAR-4	GDSC1	1.1193	3.7945	-0.7761	6.5036
Kuramochi	GDSC1	1.5449	3.9631	-0.5793	4.0186
ES-2	GDSC1	2.1544	3.5436	-0.1002	0.4469
-----------

Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Pancreas Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
MZ-PC-1	GDSC1	0.8643	3.7746	-0.9503	8.5764
PSN1	GDSC1	2.7992	4.5624	-0.219	0.4667
-----------

Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Pleura Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
IST-Mes1	GDSC1	2.3426	4.1754	-0.2597	0.9216
MPP 89	GDSC1	2.8164	4.5848	-0.2204	0.4623
MSTO-211H	GDSC1	2.8421	4.941	-0.3407	0.8533
-----------

Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Prostate Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
LNCaP clone FGC	GDSC1	2.6293	4.6232	-0.3092	0.8904
VCaP	GDSC1	2.6796	4.0744	-0.092	0.2016
-----------

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
A-253	GDSC1	2.75	4.5037	-0.2167	0.4851
-----------

Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Skin Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
COLO 800	GDSC1	1.6664	5.224	-1.0915	7.3884
UACC-257	GDSC1	1.7238	6.1869	-1.5132	10.2133
SK-MEL-2	GDSC1	1.7672	2.756	0.0345	0.2394
CP66-MEL	GDSC1	1.7802	2.8555	0.0038	0.3246
SH-4	GDSC1	1.8175	5.8578	-1.2929	8.4338
MZ-MEL-7	GDSC1	1.8286	3.5473	-0.2434	1.3853
IST-MEL1	GDSC1	1.9462	8.2455	-2.3547	15.0209
GAK	GDSC1	1.9998	3.1433	-0.0155	0.2707
SK-MEL-1	GDSC1	2.0233	8.1397	-2.2491	14.1736
CP67-MEL	GDSC1	2.0282	16.2195	-6.2288	29.8871
LB2518-MEL	GDSC1	2.0392	3.3548	-0.0766	0.4372
A-388	GDSC1	2.0575	6.5016	-1.4407	8.8561
MMAc-SF	GDSC1	2.0626	11.3549	-3.794	21.9715
MZ-MEL-2	GDSC1	2.0869	4.8294	-0.656	3.4741
A101D	GDSC1	2.1374	3.6087	-0.131	0.5659
LB373-MEL-D	GDSC1	2.4142	12.2179	-3.9593	21.7004
COLO 829	GDSC1	2.8748	8.1762	-1.7075	8.7142
LOX-IMVI	GDSC1	2.901	9.1246	-2.1321	11.2495
DJM-1	GDSC1	3.0423	4.7024	-0.1783	0.2661
HT-144	GDSC1	4.0561	20.3775	-6.7635	26.6175
-----------


⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
HuTu 80	GDSC1	2.3632	3.905	-0.15	0.4884
-----------

Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Soft Tissue Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SW684	GDSC1	1.3647	3.0458	-0.2703	2.2679
TE 441.T	GDSC1	1.7603	3.0876	-0.0914	0.7047
SW982	GDSC1	1.8282	3.2285	-0.1165	0.754
VA-ES-BJ	GDSC1	1.8992	3.8908	-0.3512	1.8966
MFH-ino	GDSC1	2.2383	3.894	-0.1966	0.7447
SK-LMS-1	GDSC1	2.4613	4.2174	-0.226	0.6926
EW-8	GDSC1	3.1126	4.9149	-0.2265	0.3499
SK-UT-1	GDSC1	3.5508	15.603	-4.7969	22.0514
SW872	GDSC1	5.519	19.2613	-5.2177	19.408
-----------


⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug

Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Stomach Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SCH	GDSC1	1.7486	8.7227	-2.731	17.7386
GCIY	GDSC1	1.968	4.2362	-0.4624	2.4568
SNU-1	GDSC1	2.1063	5.8163	-1.0899	6.3416
SNU-5	GDSC1	2.2284	3.8587	-0.1873	0.7155
RF-48	GDSC1	2.2321	4.2147	-0.3241	1.329
HSC-39	GDSC1	2.3024	4.1152	-0.2539	0.9315
SNU-16	GDSC1	2.4068	3.6641	-0.0484	0.196
-----------


⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug

Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Thyroid Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
CGTH-W-1	GDSC1	1.6641	3.0681	-0.1268	0.9702
K5	GDSC1	2.9184	4.7251	-0.2318	0.4458
-----------

Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Upper Aerodigestive Tract Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
BB49-HNC	GDSC1	0.9307	4.1417	-1.0817	9.3699
SCC-15	GDSC1	2.5374	4.5617	-0.3246	1.0312
BB30-HNC	GDSC1	2.6781	4.4662	-0.2311	0.5702
LB771-HNC	GDSC1	2.8521	14.4836	-4.7509	23.5526
-----------

Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Urogenital System Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
NT2-D1	GDSC1	1.5249	3.1496	-0.2289	1.7303
SW962	GDSC1	1.6136	4.1947	-0.644	4.3235
NEC8	GDSC1	1.6425	7.3703	-2.1453	14.6171
LB831-BLC	GDSC1	1.6674	3.7478	-0.4118	2.6438
OMC-1 [Human cervical carcinoma]	GDSC1	2.1314	3.9366	-0.2594	1.12
JAR	GDSC1	2.2364	3.7552	-0.1454	0.5511
SW954	GDSC1	2.707	4.795	-0.3418	0.9609
DSH1	GDSC1	2.862	4.5135	-0.1781	0.3292
NCC-IT	GDSC1	2.9042	4.5033	-0.1592	0.2703
KGN	GDSC1	3.6224	5.8124	-0.3534	0.4614
-----------


⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug

References

1	Allosteric inhibitors of Bcr-abl-dependent cell proliferation. Nat Chem Biol. 2006 Feb;2(2):95-102.