Details of the Drug

General Information of Drug (ID: DM4EL6M)

Drug Name

3-chloro-N-(4-methylthiazol-2-yl)benzamide

Synonyms

3-chloro-N-(4-methyl-1,3-thiazol-2-yl)benzamide; CHEMBL212529; 3-chloro-N-(4-methylthiazol-2-yl)benzamide; AC1LI75J; MolPort-003-812-188; ZINC477397; BDBM50186320; AKOS003848769; MCULE-7000942763

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 0

Molecular Weight (mw)

252.72

Logarithm of the Partition Coefficient (xlogp)

3.1

Rotatable Bond Count (rotbonds)

2

Hydrogen Bond Donor Count (hbonddonor)

1

Hydrogen Bond Acceptor Count (hbondacc)

3

Chemical Identifiers

Formula: C11H9ClN2OS
IUPAC Name: 3-chloro-N-(4-methyl-1,3-thiazol-2-yl)benzamide
Canonical SMILES: CC1=CSC(=N1)NC(=O)C2=CC(=CC=C2)Cl
InChI: InChI=1S/C11H9ClN2OS/c1-7-6-16-11(13-7)14-10(15)8-3-2-4-9(12)5-8/h2-6H,1H3,(H,13,14,15)
InChIKey: MXGUAAMFCPDOEZ-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 899301
TTD ID: D02XFR

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Metabotropic glutamate receptor 5 (mGluR5)	TTHS256	GRM5_HUMAN	Inhibitor	[1]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Metabotropic glutamate receptor 5 (mGluR5)	DTT	GRM5	9.81E-07	-0.26	-0.54

Molecular Expression Atlas (MEA)

MEA Detail

Jump to Detail Molecular Expression Atlas of This Drug

References

1	Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3371-5.