Details of the Drug

General Information of Drug (ID: DM4G09S)

Drug Name
SB-505124
Synonyms
SB-505124; 694433-59-5; SB505124; SB 505124; 2-(4-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine; CHEMBL226838; 2-[4-(1,3-Benzodioxol-5-yl)-2-(tert-butyl)-1H-imidazol-5-yl]-6-methylpyridine; 2-[5-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)-1H-imidazol-4-yl]-6-methylpyridine; 2-[4-(2H-1,3-benzodioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl]-6-methylpyridine; MLS006010969; SCHEMBL373422; GTPL6049; CTK8E3615; KS-00000XPS; EX-A217; DTXSID50431926; AOB1766; AOB5688; MolPort-021-804-897; CHEBI:100922
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 335.4
Logarithm of the Partition Coefficient (xlogp) 4.3
Rotatable Bond Count (rotbonds) 3
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C20H21N3O2
IUPAC Name
2-[4-(1,3-benzodioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl]-6-methylpyridine
Canonical SMILES
CC1=NC(=CC=C1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=C(C=C3)OCO4
InChI
InChI=1S/C20H21N3O2/c1-12-6-5-7-14(21-12)18-17(22-19(23-18)20(2,3)4)13-8-9-15-16(10-13)25-11-24-15/h5-10H,11H2,1-4H3,(H,22,23)
InChIKey
WGZOTBUYUFBEPZ-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
9858940
ChEBI ID
CHEBI:100922
CAS Number
694433-59-5
TTD ID
D0Q5UH
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
TGF-beta receptor type I (TGFBR1) TTP4520 TGFR1_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
TGF-beta receptor type I (TGFBR1) DTT TGFBR1 2.62E-01 0.27 1.01
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 5.9555 8.8587 3.2269 3.7387
NOS-1 [Human HNSCC] GDSC1 1.2257 2.9763 1.1936 34.5775
CADO-ES1 GDSC1 1.4166 2.5271 1.4134 32.2995
EW-7 GDSC1 1.493 3.6368 1.3911 31.9941
ES4 GDSC1 1.6577 4.0173 1.4915 30.5292
EW-13 GDSC1 1.8557 3.3614 1.8192 27.6069
ES7 GDSC1 2.1544 5.5207 1.5476 27.5908
ES1 GDSC1 2.4972 5.8551 1.7731 24.615
EW-16 GDSC1 2.6937 6.4883 1.6988 24.1367
U-CH2 GDSC2 2.7852 4.3468 2.3143 8.1336
H-EMC-SS GDSC1 2.82 4.6638 2.5782 18.1264
HuO9 GDSC1 3.2959 6.8367 2.1328 18.8773
EW-22 GDSC1 3.4063 5.5527 2.8412 13.7583
EW-18 GDSC1 3.5033 6.3562 2.5619 15.2273
EW-3 GDSC1 3.8087 6.3828 2.8378 12.1743
HOS GDSC1 3.9943 6.0767 3.1585 9.2744
SK-ES-1 GDSC1 4.0424 7.0945 2.6963 12.3005
EW-11 GDSC1 4.1517 8.7847 1.2474 13.1933
MHH-ES-1 GDSC1; GDSC2 4.1992 6.739 3.0096 7.8808
U2OS GDSC1; GDSC2 4.2162 5.7028 3.5416 4.7776
EW-24 GDSC1 4.2215 5.7809 3.5072 6.0435
TC-71 GDSC1 4.2656 9.218 1.8268 17.2044
ES5 GDSC1; GDSC2 4.2775 7.0424 2.9245 8.157
CHSA0011 GDSC1; GDSC2 4.2827 8.6664 1.402 9.548
HuO-3N1 GDSC1 4.392 8.0587 2.5116 12.3864
SaOS-2 GDSC1 4.4053 10.9139 1.0952 20.8548
NY GDSC1 4.5429 7.3113 3.0072 8.5205
MG-63 GDSC1 4.6608 6.9012 3.3027 6.1247
ES8 GDSC1 4.7583 7.0632 3.2958 5.9038
SK-PN-DW GDSC1 4.9371 9.4089 2.2711 12.3145
CHSA0108 GDSC1; GDSC2 5.0699 9.1779 1.6909 6.1777
A-673 GDSC1 5.1454 8.6401 2.8047 8.2233
ES6 GDSC1 5.2047 9.9668 2.1971 12.033
EW-1 GDSC1 5.2215 8.5578 2.8988 7.4014
CAL-72 GDSC1 5.6025 9.0051 2.9422 6.2207
SJSA-1 GDSC1 5.6124 7.627 3.5805 2.2305
CHSA8926 GDSC1 6.1898 8.0406 3.6934 0.9672
EW-12 GDSC2 6.1908 7.9511 2.7555 0.2209
CAL-78 GDSC1 6.2031 8.5239 3.5044 1.8269
G-292 clone A141B1 GDSC1 6.5014 10.3797 2.8588 4.9727
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 167 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1; GDSC2 3.458 4.7059 3.2521 8.9022
VL51 GDSC1 -0.9674 1.7894 -1.004 58.269
RPMI-8866 GDSC1 1.2396 2.992 1.2068 34.4265
MOLT-13 GDSC1 1.4062 3.9181 1.2404 33.2892
GA-10 GDSC1 1.4388 2.2831 1.4384 32.037
SU-DHL-16 GDSC1; GDSC2 1.4838 2.4163 1.4827 25.8884
SU-DHL-8 GDSC1 1.5502 2.2418 1.5501 30.7974
SU-DHL-5 GDSC1 1.5892 2.1811 1.5891 30.3641
P30/OHK GDSC1 1.6948 3.4389 1.6388 29.5038
Karpas-231 GDSC1 1.7142 2.3701 1.7141 28.9748
BL-41 GDSC1 1.8066 2.2855 1.8066 27.9476
MOLP-8 GDSC1 1.8382 2.4024 1.8382 27.5966
Ku812 GDSC1 1.862 3.4737 1.8125 27.6111
KE-37 GDSC1 1.8661 2.7903 1.8636 27.3007
697 GDSC1 1.87 2.5842 1.8697 27.2452
MOLT-16 GDSC1 1.9257 3.4577 1.8822 26.8693
OCI-Ly19 GDSC1; GDSC2 1.9501 3.4564 1.9083 21.8239
SUP-B15 GDSC1 1.9834 2.9951 1.9777 29.2667
CTV-1 GDSC1 1.9844 3.3332 1.9577 26.1226
JSC-1 GDSC1 2.0166 2.8326 2.0151 28.8257
SU-DHL-6 GDSC1 2.0508 3.3809 2.023 25.3908
Karpas-620 GDSC1 2.1279 3.6495 2.0719 24.6951
SU-DHL-10 GDSC1 2.1552 2.9262 2.1537 24.083
MHH-CALL-4 GDSC2 2.3919 3.5913 2.2224 10.2492
TALL-1 [Human adult T-ALL] GDSC2 2.7521 6.629 1.1725 15.2756
BONNA-12 GDSC2 2.8151 4.2952 2.3679 7.6958
QIMR-WIL GDSC1; GDSC2 2.8808 4.8597 2.5753 14.6534
Sc-1 GDSC1 2.8926 5.1522 2.4768 18.4163
MOLT-4 GDSC1 2.9977 4.5068 2.8224 15.7496
P32/ISH GDSC1 3.0286 4.3046 2.9152 15.0312
BC-1 GDSC1 3.078 4.1778 3.0009 14.2663
OCI-AML-2 GDSC1 3.1078 4.4715 2.9533 14.4018
NU-DUL-1 GDSC1; GDSC2 3.1322 4.5078 2.9684 11.6458
ALL-SIL GDSC1 3.1344 5.0792 2.7622 15.4768
RCH-ACV GDSC1; GDSC2 3.156 4.7141 2.9244 11.7753
KOPN-8 GDSC1 3.1731 4.6231 2.9747 13.9492
RPMI-8226 GDSC1 3.2026 4.5237 3.0399 13.4021
CA46 GDSC1 3.2334 4.9538 2.917 14.0289
SCC-3 GDSC1 3.246 4.9865 2.9174 15.7125
A3/Kawakami GDSC1 3.2488 5.4274 2.7358 15.1346
Ramos.2G6.4C10 GDSC1 3.2491 5.0742 2.8853 14.1604
VAL GDSC1 3.2537 4.5587 3.0838 12.8807
MY-M12 GDSC1; GDSC2 3.276 4.8018 3.021 10.8076
K-562 GDSC1 3.3112 5.2261 2.8869 13.8704
DND-41 GDSC1 3.3536 4.6456 3.1619 11.9104
Jurkat GDSC1 3.3696 5.1392 2.9846 12.9731
IM-9 GDSC1 3.3988 10.9391 0.2157 28.4409
OCI-Ly7 GDSC1; GDSC2 3.4181 5.7138 2.2051 6.7958
SUP-B8 GDSC1; GDSC2 3.4281 8.9125 0.6146 16.3959
LAMA-84 GDSC1 3.4553 5.3895 2.964 12.7334
Raji GDSC1 3.4626 4.5722 3.3055 10.4882
Karpas-45 GDSC1 3.4629 4.9645 3.1551 11.4455
WIL2 NS GDSC1 3.472 4.9603 3.1663 11.332
SU-DHL-1 GDSC1; GDSC2 3.4898 6.4343 2.5116 12.8395
RPMI-6666 GDSC1 3.5056 5.1415 3.1246 11.4547
LP-1 GDSC1; GDSC2 3.5388 4.9315 3.2484 8.6166
L-363 GDSC1 3.5408 4.8873 3.2687 10.3571
Loucy GDSC1 3.5412 4.8837 3.2706 10.3432
MC116 GDSC1; GDSC2 3.5759 4.1387 3.5495 6.9269
CCRF-CEM GDSC1 3.6191 5.5664 3.048 11.484
JJN-3 GDSC1 3.6238 4.6686 3.4436 8.8522
MHH-CALL-2 GDSC1 3.6316 6.1853 2.1395 8.2511
ALL-PO GDSC1 3.6369 5.8535 2.9305 12.2064
MEG-01 GDSC1 3.6521 5.5559 3.0854 11.0963
MOLM-16 GDSC1; GDSC2 3.6616 5.4847 2.5089 4.2402
MN-60 GDSC1 3.6662 5.9174 2.9285 12.1034
RL GDSC1; GDSC2 3.6668 4.4209 3.5777 6.4071
ST486 GDSC1 3.6716 5.5473 3.1087 10.8591
CESS GDSC1 3.6742 6.7506 2.5331 14.7539
KCL-22 GDSC1 3.6889 4.8649 3.433 8.6234
MLMA GDSC1 3.7028 5.3774 3.2185 9.9898
GDM-1 GDSC1 3.738 5.2059 3.3327 9.0763
SU-DHL-4 GDSC1; GDSC2 3.7418 6.2061 2.8614 10.0729
HC-1 GDSC1 3.7468 5.1949 3.3464 8.9476
Jiyoye GDSC1 3.7625 5.0693 3.4193 8.3937
RPMI-8402 GDSC1 3.7633 6.6031 2.6878 13.3697
PF-382 GDSC1 3.783 6.057 2.9725 11.3474
Reh GDSC1 3.8363 6.4388 2.8358 12.0851
KMOE-2 GDSC1 3.884 7.7864 2.2124 16.1032
THP-1 GDSC1; GDSC2 3.9092 5.1081 3.548 5.679
HAL-01 GDSC1 4.0243 4.8031 3.8037 4.7204
KG-1 GDSC1 4.0244 5.3947 3.5212 6.6509
NK-92MI GDSC2 4.0307 5.992 2.5213 3.341
RS4;11 GDSC1 4.0565 6.0342 3.2357 8.5143
SK-MM-2 GDSC1 4.0771 5.0431 3.7414 4.9328
CTB-1 GDSC1; GDSC2 4.1188 6.4167 3.1008 7.5823
ME1 GDSC1 4.1203 4.9589 3.823 4.2058
SUP-HD1 GDSC1 4.1729 6.5456 3.0835 9.1703
DEL GDSC1 4.1836 5.8161 3.4566 6.5265
CRO-AP2 GDSC1; GDSC2 4.1878 6.6961 2.2905 4.3997
KMS-12-BM GDSC1 4.2028 6.839 2.9628 11.1374
CML-T1 GDSC1 4.21 7.2257 2.0514 7.1978
NALM-6 GDSC1 4.2147 7.0152 2.8849 10.4113
EB2 GDSC1 4.2357 6.8534 2.9836 9.6558
JVM-3 GDSC1 4.2455 6.2358 3.3006 7.4092
CMK GDSC1 4.2531 8.589 1.4184 11.6926
H9 GDSC1 4.2784 6.3634 3.2647 7.5521
SKM-1 GDSC1; GDSC2 4.2807 8.4104 2.2432 12.0192
NCI-H929 GDSC1 4.2856 7.9001 1.7778 9.0112
EJM GDSC1 4.2939 7.1189 2.9 10.0454
SR GDSC1 4.3179 6.1046 3.4273 6.2844
DB GDSC1 4.3257 6.3226 3.3247 6.9783
A4/Fukuda GDSC1 4.3408 6.876 2.3053 4.9855
BE-13 GDSC1 4.3796 6.387 3.337 6.7208
Kasumi-1 GDSC1; GDSC2 4.3903 6.8911 2.3297 3.7697
JeKo-1 GDSC1; GDSC2 4.4379 7.9851 1.842 6.5623
GR-ST GDSC1 4.4453 7.6871 2.741 10.6583
AMO1 GDSC1 4.5123 6.4885 3.3929 5.9251
SIG-M5 GDSC1; GDSC2 4.5127 6.3019 3.4861 4.3281
Namalwa GDSC1 4.5247 6.0634 2.7763 1.4454
OPM-2 GDSC1 4.564 6.1693 3.5914 4.3933
OCI-M1 GDSC1 4.6498 6.1814 3.6493 3.7593
NKM-1 GDSC1 4.6666 6.4176 3.5456 4.428
KY821 GDSC1 4.6875 7.123 3.2132 6.6701
ROS-50 GDSC1; GDSC2 4.6988 6.9805 3.2922 5.0008
L-428 GDSC1 4.7059 7.0271 3.2745 6.194
DG-75 GDSC1 4.7227 7.7939 2.9076 8.6793
HH [Human lymphoma] GDSC1 4.7409 6.839 3.3933 5.2788
BALL-1 GDSC1 4.806 7.5705 3.0813 7.25
NB4 GDSC1; GDSC2 4.8255 6.8108 3.4681 3.7316
SUP-M2 GDSC1 4.8845 8.8155 2.525 10.8034
L-540 GDSC1 4.9326 7.3402 3.2865 5.5108
WSU-NHL GDSC1 4.9333 6.9313 3.4849 4.1669
YT GDSC1 5.0767 7.4263 3.3448 4.7663
Daudi GDSC1 5.1019 7.0282 3.5505 3.3522
HEL GDSC1; GDSC2 5.1133 7.4901 3.339 3.8749
ATN-1 GDSC1 5.1538 7.2055 3.5004 3.5669
MHH-PREB-1 GDSC1 5.1966 8.7168 2.8039 8.0975
BV-173 GDSC1 5.2123 7.9063 3.2065 5.3709
TK [Human B-cell lymphoma] GDSC1 5.2318 7.3232 3.4948 3.4402
OCI-AML-3 GDSC1 5.2551 7.5865 3.3864 4.0918
RC-K8 GDSC1 5.311 8.275 3.0965 5.8705
Karpas-1106P GDSC1 5.3231 7.3256 2.6408 1.202
U266B1 GDSC1 5.3761 8.4176 3.072 5.8826
JURL-MK1 GDSC1 5.403 10.019 2.3164 10.7461
KM-H2 GDSC1 5.4479 7.1492 3.6997 1.8062
PL-21 GDSC1; GDSC2 5.4626 8.0588 3.297 3.477
Hs 445 GDSC1 5.4984 7.9299 3.3786 3.6463
LC4-1 GDSC1 5.5251 7.6278 3.5314 2.6614
ML-2 GDSC1 5.5288 7.8663 3.4259 3.2951
NOMO-1 GDSC1 5.5624 8.0209 3.3754 3.5444
OCI-AML-5 GDSC1 5.6284 8.3502 3.2644 4.1101
DoHH2 GDSC1; GDSC2 5.6301 7.0806 3.8204 0.7774
Farage GDSC1; GDSC2 5.6355 8.6846 3.1139 4.1482
HT GDSC1; GDSC2 5.7319 8.6432 3.1927 3.5805
Granta-519 GDSC1 5.7419 8.1744 3.4108 3.0098
EHEB GDSC1 5.7631 10.5533 2.3101 9.883
KMS-11 GDSC1; GDSC2 5.8125 8.9456 3.1026 3.916
L-1236 GDSC1 5.8458 8.006 3.5413 2.1025
WSU-DLCL2 GDSC1 5.8636 7.2054 3.8747 0.5227
EM-2 GDSC1 5.9185 7.5614 3.7607 0.9283
SUP-T1 GDSC1 5.9256 8.0525 3.5628 1.8777
TUR GDSC1 5.9925 7.8135 3.694 1.1516
Karpas-422 GDSC1 6.0028 7.5361 3.8075 0.6676
Mono-Mac-6 GDSC1 6.0881 8.695 3.3727 2.6814
P12-Ichikawa GDSC1 6.0939 7.4343 3.8826 0.3613
P31/FUJ GDSC1 6.1774 7.1407 4.0149 0.0702
ARH-77 GDSC1 6.2677 8.042 3.7267 0.7722
BC-3 GDSC1; GDSC2 6.2876 8.0504 3.732 0.6055
HDLM-2 GDSC1 6.3511 8.4669 3.5976 1.2274
Karpas-299 GDSC1 6.4513 8.0107 3.8125 0.383
HL-60 GDSC1 6.4551 7.5537 3.9719 0.0774
U-698-M GDSC1 6.5781 8.7178 3.6001 1.0171
MOLM-13 GDSC1 6.6 8.4259 3.7196 0.5769
MV4-11 GDSC1 6.7214 8.3558 3.7917 0.322
EoL-1 GDSC1 6.8506 8.4049 3.8217 0.2173
JVM-2 GDSC1 7.0759 9.26 3.6023 0.6708
⏷ Show the Full List of 167 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESO-26 GDSC1 0.621 3.1065 0.5382 41.4741
KYSE-220 GDSC1 3.8687 5.9905 3.0852 10.2467
TE-12 GDSC1; GDSC2 4.052 7.0193 2.7422 9.8247
HCE-4 GDSC1; GDSC2 4.1034 6.4785 3.0565 7.8794
ESO-51 GDSC1 4.4688 8.6263 1.5541 10.1088
SK-GT-4 GDSC1 4.7492 7.9191 2.8658 8.8892
KYSE-50 GDSC1 5.1554 6.7787 3.699 2.3018
KYAE-1 GDSC1 5.5123 7.544 3.5615 2.5039
OACP4 C GDSC1 6.16 9.7941 2.9235 5.2025
OACM5.1 C GDSC1 6.2606 8.7382 3.4436 2.0645
FLO-1 GDSC1 7.5326 9.96 3.5264 0.6533
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 1.7193 5.157 1.2166 31.6451
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NB1 GDSC1 -0.0414 1.9246 -0.0549 48.5011
IMR-5 GDSC1 1.3613 3.8446 1.2076 33.719
SJNB-7 GDSC1 1.4565 4.6713 1.0929 33.7395
NB69 GDSC1 1.581 4.2303 1.3552 35.5477
SJNB-14 GDSC1 1.5891 3.6148 1.4986 30.8686
SJNB-17 GDSC1; GDSC2 1.984 4.7384 1.6457 22.9562
CHP-134 GDSC1 2.0353 5.7645 1.3248 32.7648
KP-N-YN GDSC1 2.1544 4.7656 1.822 26.0171
Kelly GDSC1 2.1662 3.9772 2.0537 24.5969
SK-N-MC-IXC GDSC1; GDSC2 2.2806 3.4428 2.2588 18.7171
SJNB-12 GDSC1 2.2915 7.434 0.8644 30.3881
SiMa GDSC1 2.5693 7.41 1.1521 27.6963
KP-N-YS GDSC1; GDSC2 2.9986 4.7644 2.7367 13.3597
CHP-126 GDSC1; GDSC2 3.267 6.2989 1.7875 9.8657
SJNB-6 GDSC1; GDSC2 3.5607 6.8742 2.3667 13.4216
LA-N-6 GDSC1; GDSC2 3.5753 6.597 2.5149 12.5471
TGW GDSC1 3.6436 5.9005 2.9146 12.2874
SJNB-5 GDSC1; GDSC2 3.7524 6.829 2.567 11.7033
NB(TU)1 GDSC1 4.1053 5.7421 3.4241 7.0275
MHH-NB-11 GDSC2 4.1067 6.1598 2.4916 3.3652
KP-N-RT-BM-1 GDSC2 4.1068 7.1348 2.0234 6.1954
NH-12 GDSC1 4.1613 7.6947 2.4999 13.2267
SK-N-SH GDSC1 4.2374 8.6818 2.0711 15.7811
CHP-212 GDSC1 4.2401 6.4059 3.211 8.0541
SK-N-FI GDSC1 4.341 9.6331 1.6822 17.8184
SK-N-AS GDSC1 4.3485 7.1491 2.9304 9.6582
SK-N-DZ GDSC1 4.7519 6.8508 3.3955 5.2344
SJNB-10 GDSC1 5.1892 12.6313 0.8661 19.585
SK-N-BE(2)-M17 GDSC1 5.8684 9.8922 2.6961 7.2107
GI-ME-N GDSC1 6.4971 10.2919 2.8956 4.7646
SJNB-13 GDSC1 6.6847 8.5241 3.7171 0.5373
GOTO GDSC1 6.8016 8.7516 3.68 0.5855
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 3.6967 4.6567 3.5259 7.988
Cancer Drug Sensitivity Data Curated from 52 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BT-483 GDSC1 1.5475 3.6406 1.4492 31.3718
MRK-nu-1 GDSC1 1.5768 2.6704 1.5728 30.5238
HCC1419 GDSC1 1.7327 4.7635 1.3643 30.8057
MDA-MB-468 GDSC1 1.9392 3.753 1.8519 26.9693
HCC1500 GDSC1 1.9825 4.0219 1.8441 26.7836
CAL-148 GDSC1 2.0323 3.695 1.9622 29.0639
UACC-812 GDSC1 2.8558 4.3282 2.7201 19.217
HCC38 GDSC1 2.9846 5.7771 2.3115 19.0544
COLO 824 GDSC1 3.0172 5.3479 2.5289 17.5108
HCC1954 GDSC1 3.4251 5.2362 3.0005 12.6234
MDA-MB-453 GDSC1 3.4601 5.7169 2.8204 13.6704
MDA-MB-361 GDSC1 3.4646 6.9984 2.2159 17.6644
OCUB-M GDSC1 3.4855 6.0379 2.6958 14.4012
BT-20 GDSC1 3.5138 5.1074 3.1478 11.2665
HCC202 GDSC1 3.5449 7.6937 1.9515 19.0329
BT-474 GDSC1 3.5762 5.9014 2.8488 13.0032
MDA-MB-330 GDSC1; GDSC2 3.6452 6.6681 2.5461 12.1516
YMB-1-E GDSC1; GDSC2 3.6613 6.7233 2.5343 12.1677
AU565 GDSC1 3.8688 5.9291 3.1153 10.0393
HCC1395 GDSC1 3.9273 6.4802 2.8985 11.3184
HCC2218 GDSC1; GDSC2 4.0729 6.0232 3.2558 6.8255
JIMT-1 GDSC1 4.1182 7.7342 1.7391 9.7803
CAMA-1 GDSC1 4.1453 7.0889 2.7886 11.311
EFM-19 GDSC1 4.1788 7.2479 2.738 11.5457
UACC-893 GDSC1; GDSC2 4.3317 6.3124 3.3349 5.6536
MDA-MB-175-VII GDSC1 4.4124 6.2662 3.4241 6.009
T-47D GDSC1 4.4333 10.6384 1.256 19.9159
CAL-51 GDSC1 4.4357 6.8057 3.1735 7.6895
EFM-192A GDSC1 4.5109 7.1483 3.063 8.2295
MFM-223 GDSC1 4.5812 6.034 3.6712 3.7919
MCF-7 GDSC1 4.6248 7.402 3.0264 8.1436
DU4475 GDSC1 4.6578 7.4225 3.0419 7.9405
CAL-120 GDSC1 4.6657 7.4142 3.0521 7.847
HCC1428 GDSC1 4.7526 8.0203 2.8183 9.2046
MDA-MB-157 GDSC1 4.8822 9.0948 2.3849 11.7345
HCC1599 GDSC1; GDSC2 4.8841 7.1533 3.343 4.3094
MDA-MB-231 GDSC1 5.0289 9.0812 2.5027 10.5446
ZR-75-30 GDSC1 5.1133 7.5114 3.3288 4.7875
HCC1937 GDSC1 5.2503 8.5989 2.899 7.3285
HCC1187 GDSC1 5.267 8.6642 2.879 7.4201
Evsa-T GDSC1 5.3229 11.1722 1.691 14.7786
HCC70 GDSC1 5.5043 10.8415 1.9873 12.5257
MDA-MB-415 GDSC1 5.515 8.2746 3.2293 4.5587
HCC1143 GDSC1 5.53 8.0286 2.4549 1.9037
HCC1569 GDSC1; GDSC2 5.5789 9.2734 2.7992 5.9337
HCC1806 GDSC1 5.5804 9.9483 2.4759 9.2809
HDQ-P1 GDSC1 5.6385 8.725 3.097 5.1489
MDA-MB-436 GDSC1 5.6527 14.6189 0.236 21.1654
CAL-85-1 GDSC1 5.773 8.1851 3.4236 2.8825
Hs 578T GDSC1 6.3877 8.7988 3.4809 1.7267
BT-549 GDSC1 6.48 8.1338 3.7791 0.4624
HCC2157 GDSC1 6.7851 8.3152 3.8292 0.2219
⏷ Show the Full List of 52 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 55 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PFSK-1 GDSC1 1.5518 2.9271 1.537 30.8614
D283 Med GDSC1 1.6397 5.386 1.0481 32.9122
U-251MG GDSC1 2.4239 5.5941 1.804 24.7843
D-245MG GDSC2 2.4378 5.5151 1.423 14.8453
MOG-G-UVW GDSC1 3.3205 5.4467 2.8011 14.3927
GaMG GDSC1 3.5271 5.2738 3.0887 11.5981
SK-MG-1 GDSC1 3.7093 5.4048 3.2123 10.0046
8-MG-BA GDSC1 3.8401 6.3585 2.8786 11.7764
H4 GDSC1 3.8407 4.8685 3.5884 6.9356
AM-38 GDSC1 3.8585 5.7108 3.2115 9.4165
GB-1 GDSC1 3.9186 6.3141 2.9725 10.8391
42-MG-BA GDSC1 4.1427 6.3373 3.1613 8.7309
D-502MG GDSC1; GDSC2 4.3903 6.2765 3.401 5.1208
KS-1 [Human Krukenberg tumour] GDSC1 4.3981 7.0257 3.033 8.7874
CAS-1 GDSC1 4.5295 6.6803 3.3109 6.4464
GI-1 GDSC1 4.6996 8.2759 2.6502 10.502
LN-18 GDSC1 4.8004 6.8576 3.4273 4.8884
YKG-1 GDSC1; GDSC2 4.8931 7.5088 3.1758 5.2295
NMC-G1 GDSC1; GDSC2 4.9441 8.8945 2.5312 8.7463
DBTRG-05MG GDSC1 4.9675 8.2736 2.8549 8.3561
LN-229 GDSC1 5.0686 7.8177 3.1504 6.0921
LN-405 GDSC1 5.0737 7.0546 3.5198 3.6135
D-423MG GDSC1; GDSC2 5.1982 7.5828 3.3512 3.6501
A-172 GDSC1 5.2018 8.2196 3.0487 6.448
SW1088 GDSC1 5.2276 8.2322 3.0604 6.3077
SW1783 GDSC1 5.2591 9.0316 2.695 8.6604
SF126 GDSC1; GDSC2 5.3257 7.0704 3.6666 1.8017
D-336MG GDSC1; GDSC2 5.4318 9.0349 2.814 6.1363
Hs 683 GDSC1; GDSC2 5.4677 7.6793 3.4747 2.5511
Onda 10 GDSC1; GDSC2 5.4741 7.1138 3.7289 1.3173
KNS-81-FD GDSC1; GDSC2 5.4943 8.5606 3.0819 4.5648
SF295 GDSC1; GDSC2 5.5215 8.9274 2.9258 5.3564
Becker GDSC1 5.6983 8.6729 3.1584 4.6384
M059J GDSC1 5.7687 8.1948 3.4169 2.9289
MOG-G-CCM GDSC1 5.822 10.009 2.6103 7.8567
YH-13 GDSC1 6.1086 8.712 3.3762 2.6314
D-263MG GDSC1 6.1549 7.5081 3.8795 0.3403
D-566MG GDSC1; GDSC2 6.1908 9.2059 3.2054 2.853
KALS-1 GDSC1 6.3289 11.0248 2.4589 7.6995
SNB-75 GDSC1; GDSC2 6.3343 8.8135 3.4488 1.5983
D-247MG GDSC1; GDSC2 6.4052 8.5076 3.606 0.937
LNZTA3WT4 GDSC1 6.413 9.3506 3.2622 2.8192
D-542MG GDSC1; GDSC2 6.4923 8.0983 3.7968 0.3336
KNS-42 GDSC1; GDSC2 6.5135 8.1093 3.801 0.3164
U-87MG ATCC GDSC1 6.5183 7.7315 3.9341 0.1138
U-118MG GDSC1 6.5749 8.1215 3.8198 0.3122
Daoy GDSC1 6.5896 8.3826 3.7314 0.5463
ONS-76 GDSC1 6.679 8.4343 3.7476 0.4526
DK-MG GDSC1 6.7141 7.9358 3.9328 0.0831
Onda 11 GDSC1; GDSC2 6.7318 9.4592 3.3755 1.5177
SF268 GDSC1 6.8436 8.6994 3.7154 0.4624
D-392MG GDSC1 6.8617 9.1939 3.5388 1.0311
SF539 GDSC1 6.9729 8.6056 3.7965 0.2298
KINGS-1 GDSC1 7.069 8.7688 3.7747 0.2433
T98G GDSC1 7.0838 8.9276 3.7248 0.3406
⏷ Show the Full List of 55 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC1TKB GDSC1 3.684 5.5698 3.1103 10.7977
ETK-1 GDSC1 5.8513 8.2668 3.431 2.7132
TGBC24TKB GDSC1 6.096 8.2434 3.568 1.6378
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AN3-CA GDSC1 1.5645 5.203 1.0332 33.4061
MFE-280 GDSC1 2.8996 5.2243 2.4556 18.5182
RL95-2 GDSC1 3.8774 6.5836 2.8022 12.1637
EN GDSC1 3.9444 5.5555 3.3679 8.0115
MFE-296 GDSC1 4.2255 6.9676 2.9179 10.1463
MFE-319 GDSC1 4.3176 5.4115 3.7735 3.8589
ESS-1 GDSC1 4.3741 6.8199 3.1161 8.283
KLE GDSC1 4.5231 7.035 3.1292 7.7317
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
769-P GDSC1 2.5985 4.1719 2.4798 19.8356
KTCTL-140 GDSC1; GDSC2 4.1144 7.7599 2.4271 11.4406
786-O GDSC1 4.3992 6.1413 3.4758 5.6873
SW13 GDSC1 5.2512 8.8516 2.777 8.1377
VMRC-RCZ GDSC1 5.4283 7.3951 3.5801 2.5365
KTCTL-21 GDSC1; GDSC2 5.5066 9.3411 2.7178 6.5147
RCC10RGB GDSC1 5.5076 8.5809 3.0809 6.2095
NCC021 GDSC1; GDSC2 5.5483 7.7411 3.4939 2.3362
A-498 GDSC1 5.8736 7.3463 3.8251 0.7013
KTCTL-26A GDSC1; GDSC2 5.9225 8.1639 3.5138 1.7597
NCC010 GDSC1; GDSC2 5.9407 8.5989 2.4159 1.3188
BFTC-909 GDSC1 5.9471 7.9249 3.6269 1.5223
KMRC-1 GDSC1 6.0658 7.6356 3.7963 0.6628
HA7-RCC GDSC1; GDSC2 6.1867 8.6196 3.4562 1.7192
KTCTL-13 GDSC1; GDSC2 6.2739 8.4328 3.5757 1.1519
SW156 GDSC1; GDSC2 6.2791 9.3204 3.2037 2.7466
CAL-54 GDSC1 6.3287 9.4498 3.1742 3.4322
ACHN GDSC1 6.3435 8.7063 3.4975 1.6965
A-704 GDSC1 6.3627 9.2025 3.2993 2.689
KTCTL-1M GDSC1; GDSC2 6.3751 9.0446 3.3726 1.8763
TK-10 GDSC1 6.4371 9.4605 3.2277 2.9726
OS-RC-2 GDSC1 6.4756 8.1554 3.7695 0.4932
UO-31 GDSC1; GDSC2 6.5165 8.4228 3.6867 0.6067
KMRC-20 GDSC1 6.6479 8.1922 3.822 0.2803
VMRC-RCW GDSC1; GDSC2 6.7028 8.1293 3.8637 0.1493
Caki-1 GDSC1; GDSC2 6.8211 9.7863 3.2846 1.7936
BB65-RCC GDSC1; GDSC2 6.8335 8.8711 3.6488 0.5456
KTCTL-195 GDSC1 7.0139 8.7735 3.7531 0.3034
SN12C GDSC1 7.0298 8.817 3.7437 0.318
RXF 393L GDSC1; GDSC2 7.0519 9.0902 3.6548 0.4347
LB1047-RCC GDSC1; GDSC2 7.2204 9.3824 3.6144 0.4597
LB2241-RCC GDSC1; GDSC2 7.2846 9.1881 3.7074 0.2543
LB996-RCC GDSC1 7.3893 9.1645 3.7529 0.1993
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 48 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
C2BBe1 GDSC1; GDSC2 0.9865 4.7412 0.2824 27.0431
SK-CO-1 GDSC1; GDSC2 2.0311 5.9281 0.8322 19.7666
NCI-H747 GDSC1; GDSC2 2.9164 4.7525 2.6521 14.0736
COLO205 GDSC1; GDSC2 3.3327 6.3317 2.4081 13.8861
SNU-407 GDSC1; GDSC2 3.3608 6.211 2.4923 13.3293
HCT 116 GDSC1; GDSC2 3.378 4.6105 3.2007 9.4508
LS513 GDSC1; GDSC2 3.5481 5.9943 2.7775 11.1309
HT-29 GDSC1; GDSC2 3.5668 5.6848 2.9412 10.1617
DiFi GDSC1; GDSC2 3.6733 7.8955 1.3209 11.5553
T84 GDSC1; GDSC2 3.8238 6.4598 2.814 10.0552
RKO GDSC1; GDSC2 3.8549 7.0561 2.5485 11.4631
SNU-81 GDSC1; GDSC2 3.8559 7.7192 2.2208 13.2982
KM12 GDSC1; GDSC2 4.0176 6.2364 3.1006 7.8498
LS180 GDSC1; GDSC2 4.0357 6.2606 3.1048 7.7733
SW1417 GDSC1; GDSC2 4.1162 7.0078 2.804 9.2608
LS411N GDSC1; GDSC2 4.1694 7.1218 2.7929 9.1763
HT-55 GDSC1; GDSC2 4.1759 7.5642 2.5776 10.3844
NCI-H508 GDSC1; GDSC2 4.2218 6.5528 2.3807 3.7808
SW837 GDSC1; GDSC2 4.2319 9.5024 1.6563 15.2983
CL-11 GDSC1; GDSC2 4.2466 6.1594 3.3397 5.8351
SNU-61 GDSC1 4.3584 7.1469 2.9397 9.562
SNU-283 GDSC2 4.3876 6.4668 2.5238 2.6669
SNU-C2B GDSC1; GDSC2 4.5694 7.5993 2.8846 7.6114
LS123 GDSC1; GDSC2 4.5716 8.775 2.2999 10.9084
MDST8 GDSC1; GDSC2 4.6635 8.0237 2.7474 8.1623
RCM-1 [Human ESC] GDSC1; GDSC2 4.7116 10.0439 1.7788 13.3911
SNU-1040 GDSC1; GDSC2 4.7138 7.8732 2.8613 7.3961
SW1116 GDSC1; GDSC2 4.7764 8.408 2.6442 8.4761
SW626 GDSC1 4.7906 7.9115 2.9012 8.5294
COLO 320HSR GDSC1; GDSC2 4.8666 7.7118 3.0567 5.9405
LS1034 GDSC1; GDSC2 4.9328 8.1263 2.9017 6.6672
SNU-175 GDSC1; GDSC2 5.0984 9.8844 2.1583 10.4202
HT115 GDSC1; GDSC2 5.1206 6.5251 3.7932 1.4648
SNU-C1 GDSC1; GDSC2 5.225 8.5947 2.8834 6.1485
SNU-C5 GDSC1; GDSC2 5.2761 7.3651 3.5029 2.6993
NCI-H716 GDSC1; GDSC2 5.2819 8.8669 2.7913 6.5406
CaR-1 GDSC1; GDSC2 5.2897 7.7132 3.3491 3.4864
COLO 678 GDSC1; GDSC2 5.4223 8.3949 3.1133 4.5116
SW1463 GDSC1; GDSC2 5.6007 8.9041 2.9887 4.8579
LoVo GDSC1; GDSC2 5.7193 9.31 2.8741 5.2568
HCC2998 GDSC1; GDSC2 5.8137 7.9546 3.5465 1.7344
SW620 GDSC1; GDSC2 5.8999 8.7495 3.2439 3.0581
SW48 GDSC1; GDSC2 5.9836 9.5599 2.9242 4.5463
SW948 GDSC1; GDSC2 6.0426 8.1079 3.5979 1.2705
GP5d GDSC1; GDSC2 6.0628 8.2576 3.5457 1.4649
CW-2 GDSC1; GDSC2 6.1556 8.5896 3.453 1.7605
CCK-81 GDSC1; GDSC2 6.6594 8.6827 3.648 0.6364
HCT 15 GDSC1; GDSC2 6.6675 10.7169 2.8029 4.1249
⏷ Show the Full List of 48 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 3.8297 6.1061 2.9925 11.0322
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-HEP-1 GDSC1 2.3558 4.4672 2.1349 23.1364
Huh-7 GDSC1 2.5395 5.2101 2.0783 22.5734
JHH-7 GDSC1 3.6771 7.979 1.9317 18.6515
JHH-4 GDSC1 3.7051 6.7438 2.565 14.4217
Hep-G2/C3A GDSC1 4.3756 10.0091 1.523 18.6276
JHH-1 GDSC1 4.4939 7.0521 3.0973 8.0422
SNU-423 GDSC1 4.5396 12.0284 0.6485 22.6071
SNU-475 GDSC1 4.9535 8.826 2.5722 11.5109
HuH-1 GDSC1 5.0279 7.1029 3.4666 4.0674
Hep 3B2.1-7 GDSC1; GDSC2 5.2319 8.4563 2.9552 5.7562
SNU-449 GDSC1 5.3887 7.1899 3.6491 2.1927
JHH-6 GDSC1 5.4535 10.0798 2.3229 10.5745
HLE GDSC1 5.5138 10.8466 1.9917 12.4742
JHH-2 GDSC1 5.6578 11.9337 1.5638 14.5964
SNU-398 GDSC1 5.9254 13.94 0.775 17.9993
SNU-387 GDSC1 6.1342 8.2148 3.5982 1.4477
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 185 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COR-L303 GDSC1; GDSC2 1.3631 3.2462 1.3105 27.2269
NCI-H524 GDSC1 1.6821 3.2235 1.6503 29.509
NCI-H661 GDSC1 1.7039 3.2582 1.6698 29.2802
NCI-H187 GDSC1 1.8623 2.4214 1.8622 27.3297
NCI-H1341 GDSC1 1.927 3.777 1.8343 27.1358
A-427 GDSC1; GDSC2 1.9567 5.3774 1.3914 24.3246
SBC-5 GDSC1 1.9613 3.552 1.9078 26.5308
HCC33 GDSC1; GDSC2 2.0159 3.2531 1.9974 21.1158
NCI-H2347 GDSC1 2.0166 3.9535 1.8963 26.3008
NCI-H510A GDSC1; GDSC2 2.1761 4.1783 2.0178 20.3224
NCI-H209 GDSC1 2.2756 5.9468 1.5032 27.2323
NCI-H2066 GDSC1 2.423 6.4129 1.4563 26.7759
NCI-H1436 GDSC1; GDSC2 2.5503 4.7828 2.2455 17.6498
NCI-H847 GDSC1 2.5685 3.9661 2.4924 19.9177
CPC-N GDSC1 3.0703 5.588 2.4821 17.5752
NCI-H2196 GDSC1; GDSC2 3.071 7.3145 1.688 18.7057
NCI-H1581 GDSC1 3.3232 5.2505 2.889 13.8037
NCI-H64 GDSC1 3.3467 4.6126 3.1661 13.4071
NCI-H250 GDSC2 3.3599 6.3062 1.8613 9.1303
COR-L32 GDSC1; GDSC2 3.3727 7.8266 1.1118 13.7016
IST-SL2 GDSC1; GDSC2 3.3743 4.7819 3.1337 9.8417
NCI-H1048 GDSC1 3.3878 5.4507 2.8681 13.6593
NCI-H748 GDSC2 3.4283 6.1844 1.9783 8.1987
EPLC-272H GDSC1 3.4401 5.0556 3.0933 11.9496
NCI-H292 GDSC1; GDSC2 3.4909 4.8238 3.2416 8.8315
LK-2 GDSC1 3.5013 5.7326 2.854 13.274
NCI-H82 GDSC1 3.5165 5.2583 3.0848 11.6698
NCI-H2342 GDSC1 3.5443 4.8642 3.2818 10.2568
NCI-H1573 GDSC1 3.5473 5.1677 3.1562 11.0644
NCI-H2803 GDSC1; GDSC2 3.5798 4.6333 3.4098 7.6119
Lu-139 GDSC1 3.6471 7.4155 2.1821 17.1769
NCI-H1944 GDSC1 3.6587 6.2864 2.744 13.3875
COR-L95 GDSC1 3.8072 6.8673 1.9356 9.2577
ABC-1 GDSC1; GDSC2 3.8242 6.0693 3.0053 9.002
HCC366 GDSC1; GDSC2 3.8248 7.2635 1.753 8.5448
EKVX GDSC1; GDSC2 3.8869 5.8817 3.1552 7.9586
NCI-H1836 GDSC1; GDSC2 3.8999 7.0921 2.5712 11.238
NCI-H146 GDSC1; GDSC2 3.9122 6.8893 2.6826 10.5694
NCI-H1355 GDSC1 3.9587 6.8798 2.729 12.3715
NCI-H596 GDSC1 4.0199 6.7849 2.8304 11.4567
NCI-H1155 GDSC1 4.0601 6.2907 3.1116 9.3652
DMS 273 GDSC1 4.0701 5.9615 3.2839 8.1303
SBC-1 GDSC1; GDSC2 4.0947 6.5751 3.0008 8.2237
NCI-H69 GDSC1 4.1421 6.8432 2.9085 10.4924
NCI-H1651 GDSC1 4.1557 6.199 3.2415 8.126
NCI-H841 GDSC1 4.1908 8.982 1.8817 17.1224
NCI-H1666 GDSC1 4.1914 6.1676 3.2882 7.6774
SBC-3 GDSC1 4.2105 6.2846 3.2462 7.9068
PC-14 GDSC1; GDSC2 4.2379 5.7338 3.5448 4.699
NCI-H322M GDSC1 4.2418 6.6389 3.096 8.8526
NCI-H2818 GDSC1 4.245 6.1387 3.3486 7.0745
NCI-H1869 GDSC1 4.2565 7.2838 2.7861 10.9557
NCI-H810 GDSC1 4.2641 7.1162 2.8763 10.3075
NCI-H2141 GDSC1 4.2762 9.3929 1.7482 17.6426
BEN GDSC1; GDSC2 4.3075 6.7251 3.1083 7.0206
Lu-135 GDSC1 4.3104 9.8584 1.5441 18.724
COR-L279 GDSC1 4.3244 8.3534 1.5848 10.2996
DMS 114 GDSC1 4.3485 8.0675 2.4712 12.7983
LC-1/sq GDSC1 4.3632 7.0743 2.2263 5.5071
NCI-H211 GDSC1 4.3654 7.1368 2.9505 9.4643
LB647-SCLC GDSC1; GDSC2 4.396 6.2965 3.3957 5.1368
COR-L105 GDSC1 4.3962 7.3434 2.8726 9.9063
NCI-H1304 GDSC1 4.4693 7.2588 2.9744 8.9724
COR-L321 GDSC1; GDSC2 4.4979 6.9366 3.1582 6.2448
NCI-H1694 GDSC1 4.5198 7.5357 2.8768 9.4925
NCI-H1703 GDSC1 4.5258 8.7331 2.2838 13.4718
NCI-H1876 GDSC1 4.5269 7.0402 3.1296 7.7173
PaCa-3 GDSC1 4.5513 6.9324 3.2026 7.1364
NCI-H727 GDSC1 4.608 7.3158 3.0562 7.9869
NCI-H1435 GDSC1 4.6109 6.5411 3.443 5.2913
EMC-BAC-1 GDSC1; GDSC2 4.6293 6.9196 3.2695 5.2901
COR-L23 GDSC1 4.6473 7.207 3.1408 7.2859
IST-SL1 GDSC1; GDSC2 4.6749 8.8129 2.3635 10.3283
NCI-H2444 GDSC1; GDSC2 4.6759 6.3948 3.5636 3.5123
EBC-1 GDSC1 4.6782 6.6038 3.4626 4.9694
NCI-H522 GDSC1 4.7035 7.0006 3.2858 6.1226
NCI-H1623 GDSC1 4.7221 6.9566 3.3214 5.8253
NCI-H720 GDSC1 4.7472 9.5543 2.0511 14.2767
NCI-H345 GDSC1; GDSC2 4.757 7.7829 2.9393 6.8742
NCI-H2029 GDSC1; GDSC2 4.7598 6.9324 3.3612 4.4732
NCI-H1781 GDSC1 4.7619 7.0789 3.2907 5.9287
DMS 53 GDSC1 4.8047 7.1856 3.2698 5.958
COR-L88 GDSC1 4.807 7.7333 3.0017 7.7942
HCC827 GDSC1 4.8122 8.0033 2.8722 8.6669
HCC78 GDSC1 4.8127 6.366 3.6744 3.1818
NCI-H1770 GDSC1; GDSC2 4.8431 8.3407 2.7286 7.869
NCI-H1688 GDSC1 4.8477 6.8834 3.4485 4.6232
LCLC-97TM1 GDSC1 4.8589 6.6681 3.5606 3.8363
Lu-165 GDSC1 4.8605 9.2492 2.2915 12.4054
SW1573 GDSC1 4.8716 8.3056 2.7676 9.2112
NCI-H740 GDSC2 4.9475 7.1555 2.5303 1.8249
NCI-H290 GDSC1; GDSC2 4.9729 8.6621 2.6676 7.916
NCI-H3122 GDSC1 4.9819 9.2055 2.4059 12.6188
SHP-77 GDSC1 4.9999 6.9907 3.5015 3.9005
NCI-H226 GDSC1 5.0176 7.779 3.1333 6.336
NCI-H526 GDSC1 5.0191 7.68 3.1825 5.9987
NCI-H196 GDSC1 5.068 7.765 3.1756 5.924
Calu-6 GDSC1 5.1335 8.6989 2.7674 8.5039
CAL-12T GDSC1; GDSC2 5.1341 7.606 3.2975 4.062
NCI-H358 GDSC1 5.1773 8.9924 2.6555 9.1337
NCI-H2135 GDSC1; GDSC2 5.1845 7.3114 3.4704 3.0342
HOP-92 GDSC1 5.222 8.3757 2.1477 4.2153
KNS-62 GDSC1 5.2243 8.9926 2.6892 8.7883
HARA [Human squamous cell lung carcinoma] GDSC1 5.261 7.1232 3.6049 2.687
LCLC-103H GDSC1 5.3106 6.9463 3.7133 1.9441
NCI-H2405 GDSC1 5.3404 8.4531 3.0311 6.2347
DMS 79 GDSC1; GDSC2 5.3876 7.6633 2.5358 1.3261
RERF-LC-Sq1 GDSC1 5.391 9.1868 2.7125 8.2138
NCI-H1755 GDSC1 5.433 8.2777 3.1757 5.0779
NCI-H2291 GDSC1; GDSC2 5.4537 7.8858 3.3716 3.1016
NCI-H650 GDSC1 5.4754 9.0945 2.815 7.3387
NCI-H2081 GDSC1; GDSC2 5.4961 8.1716 3.2655 3.586
NCI-H2009 GDSC1 5.5098 8.176 3.2719 4.2977
SW1271 GDSC1 5.5099 9.4317 2.6765 8.1598
NCI-H2369 GDSC1 5.5303 7.2151 3.715 1.6018
NCI-H647 GDSC1; GDSC2 5.5489 8.2752 3.2502 3.5781
NCI-H2795 GDSC1 5.5587 7.8223 3.4634 3.0119
NCI-H1568 GDSC1 5.584 7.5733 3.5885 2.2292
NCI-H1793 GDSC1 5.5858 7.7781 3.4988 2.7516
NCI-H2810 GDSC1; GDSC2 5.6216 8.2025 3.328 3.0606
NCI-H1299 GDSC1 5.6482 8.4482 3.2314 4.2785
RERF-LC-MS GDSC1; GDSC2 5.6838 11.9256 1.5867 12.1493
NCI-H2171 GDSC1; GDSC2 5.6901 9.9634 2.5439 7.0996
NCI-H1693 GDSC1 5.704 7.8958 2.5857 1.0948
COR-L311 GDSC1 5.707 8.6348 3.1814 5.0288
NCI-H1648 GDSC1 5.7216 11.936 1.609 14.1739
NCI-H1650 GDSC1 5.7571 8.4355 3.3023 3.6349
Lu-134-A GDSC1; GDSC2 5.8228 8.8863 3.1361 3.7273
NCI-H2373 GDSC1 5.8499 8.6844 3.2441 3.8216
NCI-H2085 GDSC1 5.8538 9.2841 2.9716 5.5018
NCI-H1734 GDSC1; GDSC2 5.9145 9.6126 2.8568 5.0258
NCI-H2461 GDSC1 5.9157 9.6124 2.8576 6.0919
NCI-H2227 GDSC1; GDSC2 5.9616 16.4347 -1.1861 18.438
NCI-H1437 GDSC1; GDSC2 5.962 10.1166 2.6508 6.0256
NCI-H446 GDSC1 6.0001 11.1386 2.1904 10.0573
NCI-H3255 GDSC1; GDSC2 6.0238 7.9679 3.6463 1.1003
VMRC-LCD GDSC1 6.0308 7.8698 2.7255 0.4032
NCI-H1993 GDSC1 6.0424 7.9873 3.6472 1.3161
NCI-H835 GDSC1 6.0462 8.0973 2.65 0.6138
NCI-H2722 GDSC1 6.0538 11.3888 2.1068 10.4364
Ms-1 GDSC1 6.06 8.2538 3.5459 1.7925
Lu-99A GDSC1 6.0802 8.9321 3.2647 3.3072
NCI-H1105 GDSC1; GDSC2 6.1004 8.8881 3.2952 2.546
NCI-H1838 GDSC1 6.102 11.1191 2.2678 9.3521
NCI-H1092 GDSC1 6.1053 11.614 2.0337 10.7524
RERF-LC-KJ GDSC1 6.1158 8.6176 3.4206 2.3783
SK-LU-1 GDSC1 6.1786 8.0626 3.6798 1.0346
HCC15 GDSC1 6.2217 8.7597 3.4149 2.2645
ChaGo-K-1 GDSC1; GDSC2 6.2474 8.2338 3.6431 0.926
NCI-H1915 GDSC1 6.2496 7.9957 3.7367 0.7481
Calu-3 GDSC1 6.2546 7.8524 3.7928 0.5476
SK-MES-1 GDSC1 6.2649 8.5121 3.5392 1.584
COLO 668 GDSC1 6.2735 10.3016 2.7596 5.9838
NCI-H460 GDSC1; GDSC2 6.2856 8.531 3.5414 1.2731
NCI-H1975 GDSC1 6.2953 8.5957 3.5196 1.6444
IA-LM GDSC1 6.3161 8.5315 3.5556 1.4518
NCI-H2172 GDSC1; GDSC2 6.3338 10.8599 2.5388 5.9692
NCI-H2023 GDSC1 6.3969 10.5445 2.7227 5.9716
NCI-H838 GDSC1; GDSC2 6.3999 7.992 3.7994 0.3652
NCI-H2869 GDSC1; GDSC2 6.4067 11.3539 2.3543 6.7906
LOU-NH91 GDSC1 6.431 7.976 3.8172 0.3799
Lu-65 GDSC1 6.4976 8.6469 3.5924 1.1162
NCI-H441 GDSC1 6.5008 8.2604 3.7409 0.5672
NCI-H513 GDSC1 6.5162 8.2423 3.7537 0.5187
NCI-H520 GDSC1 6.5896 8.4516 3.7059 0.6269
NCI-H2595 GDSC1 6.6043 8.7446 3.6011 0.9923
LXF 289 GDSC1 6.6375 8.7088 3.6289 0.8616
NCI-H1792 GDSC1 6.6489 8.4768 3.7203 0.5473
NCI-H2087 GDSC1 6.6887 8.6247 3.6817 0.6453
HOP-62 GDSC1 6.7411 8.9352 3.5864 0.9427
NCI-H2170 GDSC1 6.7628 8.5235 3.7477 0.4135
LC-2/ad GDSC1; GDSC2 6.7671 8.6996 3.6854 0.4827
NCI-H2030 GDSC1; GDSC2 6.7927 8.4959 3.7688 0.286
NCI-H2122 GDSC1 6.7947 14.8067 0.9697 14.9254
UMC-11 GDSC1 6.8237 8.5634 3.7565 0.3656
HCC44 GDSC1 6.8562 8.6784 3.7278 0.4239
NCI-H2731 GDSC1 6.8621 8.9562 3.6287 0.7124
NCI-H2228 GDSC1 6.918 8.8251 3.6987 0.4728
EMC-BAC-2 GDSC1 7.1023 9.3935 3.5635 0.7785
NCI-H2804 GDSC1; GDSC2 7.1285 9.4177 3.5651 0.6216
A-549 GDSC1 7.2318 9.129 3.7087 0.3244
NCI-H23 GDSC1 7.3274 9.3381 3.6706 0.374
NCI-H2591 GDSC1 7.3549 9.3626 3.6722 0.3608
NCI-H1563 GDSC1 7.5594 15.2533 1.2612 11.8359
NCI-H2110 GDSC1; GDSC2 7.7293 9.7008 3.69 0.1815
⏷ Show the Full List of 185 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 4.6648 7.1921 3.1616 7.0916
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-5 GDSC1 2.5623 6.6368 1.4989 25.8835
TE-15 GDSC1 3.2906 5.8407 2.594 15.8882
KYSE-450 GDSC1 3.5038 4.6338 3.328 10.1502
OE19 GDSC1 3.6105 5.1411 3.2326 10.2855
T.T GDSC1 3.8767 7.2163 2.4888 14.2988
OE21 GDSC1 3.9704 6.6156 2.8704 11.3571
COLO 680N GDSC1 4.1083 5.9353 3.3309 7.6667
KYSE-150 GDSC1 4.2972 5.491 3.7167 4.3233
TE-6 GDSC1 4.3141 6.4227 3.2651 7.4332
TE-9 GDSC1 4.4056 8.0188 2.5428 12.1329
KYSE-140 GDSC1 4.6132 6.5292 3.4506 5.8855
KYSE-70 GDSC1 4.6372 6.7683 3.3505 5.8592
TE-10 GDSC1; GDSC2 4.645 6.9516 3.2657 5.2755
TE-4 GDSC1 4.6863 8.1393 2.7077 10.1513
TE-1 GDSC1 4.9091 8.1615 2.8668 8.4341
TE-8 GDSC1 5.0215 11.6676 1.2146 18.2993
KYSE-410 GDSC1 5.054 7.7398 3.178 5.9421
EC-GI-10 GDSC1 5.7111 8.1016 3.4258 2.9731
TE-11 GDSC1; GDSC2 5.9536 9.1337 3.1015 3.7009
OE33 GDSC1 6.1433 7.9362 3.7137 0.9242
KYSE-180 GDSC1 6.2496 7.8505 3.7915 0.555
KYSE-520 GDSC1 6.4821 9.4877 3.2395 2.8446
KYSE-510 GDSC1; GDSC2 6.5901 7.9879 3.872 0.1619
KYSE-270 GDSC1 6.9635 9.4449 3.4859 1.1548
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHOS-4 GDSC1; GDSC2 1.3672 3.7746 1.2286 27.5922
TOV-112D GDSC1 1.4959 4.9496 1.0461 33.7367
A2780 GDSC1 1.6717 4.1543 1.4736 30.5504
OVCAR-3 GDSC1 3.0737 6.1714 2.2255 19.216
OVCAR-4 GDSC1 3.2987 4.4529 3.1669 12.1471
Caov-4 GDSC1 3.316 4.2583 3.2408 11.6132
OVISE GDSC1 3.442 4.763 3.2133 11.1673
JHOS-2 GDSC1; GDSC2 3.6839 4.7139 3.4899 6.7944
OV-90 GDSC1 3.745 6.91 2.5204 14.572
IGROV-1 GDSC1 3.897 5.4784 3.3602 8.247
OVK18 GDSC1; GDSC2 4.2875 7.2459 2.8311 8.6658
OVKATE GDSC1 4.3224 5.873 3.5468 5.4324
Caov-3 GDSC1; GDSC2 4.5185 6.8719 3.2069 5.9149
OVCAR-5 GDSC1 4.519 6.7317 3.2771 6.713
FU-OV-1 GDSC1 4.5625 8.7327 2.3137 13.1614
EFO-21 GDSC1 4.6088 7.4204 3.0048 8.3404
OAW28 GDSC1 4.6388 6.7449 3.3634 5.7657
SK-OV-3 GDSC1 4.6522 6.3328 3.5767 4.2527
Kuramochi GDSC1 4.7177 7.9603 2.8211 9.2861
DOV13 GDSC1 4.8554 8.0234 2.8948 8.3913
OVTOKO GDSC1 5.3604 7.4874 3.4981 3.1641
TYK-nu GDSC1 5.4386 8.0354 3.2928 4.31
OVCAR-8 GDSC1 5.6089 8.788 3.0487 5.52
ES-2 GDSC1 5.6565 7.3963 3.7029 1.4962
OC 314 GDSC1 5.7297 8.6418 3.192 4.3665
OV56 GDSC1 5.7421 6.6551 4.0272 0.1489
TOV-21G GDSC1 5.9162 7.5798 3.7524 0.9666
EFO-27 GDSC1; GDSC2 6.0464 10.5767 2.4885 6.7288
OAW42 GDSC1 6.0904 7.2606 3.9432 0.2101
RMG-I GDSC1 6.7132 8.8958 3.5896 0.9517
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KP-4 GDSC1 2.6556 5.348 2.1479 21.591
Capan-2 GDSC1 3.1661 5.4405 2.6448 16.0936
AsPC-1 GDSC1 3.2831 6.5993 2.2333 18.2839
Panc 03.27 GDSC1 3.5149 5.3117 3.0594 11.8456
BxPC-3 GDSC1 3.5293 4.7546 3.3097 10.1462
SUIT-2 GDSC1 3.6431 4.9334 3.3564 9.3281
PL4 GDSC1 3.6514 4.7197 3.453 8.6642
KP-1N GDSC1 3.7271 6.43 2.7388 13.1598
QGP-1 GDSC1; GDSC2 3.9763 5.6936 3.3303 6.6899
Capan-1 GDSC1 4.2852 6.1413 3.3814 6.7122
KP-2 GDSC1 4.3995 10.872 0.403 17.7488
HuP-T4 GDSC1 4.4501 6.1662 3.5043 5.3319
SW1990 GDSC1 4.5962 6.7843 3.3112 6.2496
HPAF-II GDSC1 4.7157 7.6044 2.9962 8.0891
MZ-PC-1 GDSC1; GDSC2 4.7341 6.6658 3.4732 3.8963
PaTu 8988t GDSC1 4.773 8.9176 2.3883 12.0316
KP-3 GDSC1 4.9303 7.6839 3.117 6.672
Panc 08.13 GDSC1 5.2029 8.1875 3.065 6.3368
PSN1 GDSC1 5.2144 7.419 3.439 3.8367
YAPC GDSC1 5.2609 8.0501 3.1703 5.4982
SU.86.86 GDSC1 5.3229 7.2097 3.6024 2.5886
Hs 766T GDSC1 5.5107 7.5366 3.5638 2.4928
Panc 02.03 GDSC1 5.6037 7.4731 3.6428 1.8926
DAN-G GDSC1 5.7979 7.6414 3.6711 1.4809
PaTu 8902 GDSC1 5.9876 9.622 2.8979 5.6941
Panc 04.03 GDSC1 6.3053 8.7185 3.4739 1.8563
HPAC GDSC1 6.3283 8.0933 3.7327 0.7058
CFPAC-1 GDSC1 6.603 8.256 3.7825 0.3936
MIA PaCa-2 GDSC1 6.6453 8.0806 3.8599 0.2297
Panc 10.05 GDSC1 6.6502 8.6122 3.6707 0.7057
HuP-T3 GDSC1 6.9822 8.9101 3.6928 0.4592
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2052 GDSC1 4.608 6.7172 3.3536 6.6595
NCI-H2452 GDSC1 4.6949 6.9714 3.2937 6.0916
NCI-H28 GDSC1 5.0069 7.3905 3.3142 5.1387
MSTO-211H GDSC1 5.2544 7.9328 3.222 5.1712
IST-Mes1 GDSC1 5.2813 7.7602 3.3215 4.4573
MPP 89 GDSC1 5.3361 8.1143 3.1898 5.1993
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VCaP GDSC1 1.619 2.775 1.6129 30.0667
LNCaP clone FGC GDSC1 2.3854 5.7518 1.6991 25.5843
22Rv1 GDSC1 3.412 5.5104 2.866 13.5688
PC-3 GDSC1 3.4567 5.2111 3.044 12.1991
NCI-H660 GDSC2 3.4595 5.0041 2.5925 4.2333
DU145 GDSC1 5.3772 8.2945 3.1312 5.4912
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 3.5194 5.4439 3.0046 12.1908
Cancer Drug Sensitivity Data Curated from 57 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UACC-257 GDSC1 1.4486 5.4629 0.8144 35.0559
COLO 783 GDSC1; GDSC2 1.5811 4.9954 1.1231 27.167
SK-MEL-3 GDSC1; GDSC2 2.1086 5.6071 1.465 23.3554
Hs 938.T GDSC1; GDSC2 2.5791 5.5504 1.9854 18.8834
Mel JuSo GDSC1 2.7788 5.6545 2.1513 20.9973
CP66-MEL GDSC1; GDSC2 3.2158 6.2019 2.3533 14.6258
CP50-MEL-B GDSC1; GDSC2 3.3187 6.1328 2.4874 13.5395
IGR-1 GDSC1 3.665 7.0594 2.3734 15.8554
COLO 800 GDSC1; GDSC2 3.6922 8.699 1.5888 17.252
A-388 GDSC1; GDSC2 3.6989 5.2867 3.2565 8.003
A-431 GDSC1; GDSC2 3.716 5.1249 3.3472 7.4461
LB2518-MEL GDSC1; GDSC2 3.7795 5.5656 3.2055 8.0169
G-mel GDSC1; GDSC2 3.7822 8.0534 1.9893 14.8365
IGR-37 GDSC1 3.8775 7.2927 2.4516 14.5461
A-375 GDSC1; GDSC2 3.9045 6.3104 2.9615 9.0046
Hs 940.T GDSC1; GDSC2 4.0567 8.9222 1.1081 11.8439
SK-MEL-31 GDSC1; GDSC2 4.1603 5.8789 2.6562 2.311
COLO 679 GDSC1 4.1736 8.4831 2.1164 15.7078
CHL-1 GDSC1 4.2356 10.0614 1.3799 19.9001
MZ-MEL-7 GDSC1; GDSC2 4.4408 6.6043 3.2783 5.6982
SK-MEL-2 GDSC1 4.4735 6.2574 3.4774 5.4501
WM793 GDSC1 4.5183 7.0308 3.1274 7.7586
WT2-iPS GDSC1; GDSC2 4.614 5.9861 3.719 2.7697
IPC-298 GDSC1; GDSC2 4.6299 9.7494 1.8604 13.203
COLO 792 GDSC1 4.6572 8.0541 1.9546 6.7521
SK-MEL-30 GDSC1; GDSC2 4.7054 6.1578 3.7006 2.6801
HT-144 GDSC1 4.7253 8.3617 2.6276 10.5789
LOX-IMVI GDSC1 4.8515 8.6557 2.579 10.5384
SK-MEL-1 GDSC1 4.9297 10.8716 1.5388 16.7919
M14 GDSC1 5.0911 9.1384 2.5208 10.2547
IST-MEL1 GDSC1 5.1775 7.946 3.1638 5.7374
SK-MEL-24 GDSC1 5.1816 7.515 3.3724 4.3431
G-361 GDSC1 5.2366 8.946 2.7207 8.548
WM278 GDSC1 5.2686 10.4384 2.0124 13.0082
WM115 GDSC1 5.289 7.8666 3.2763 4.7366
MMAc-SF GDSC1; GDSC2 5.361 9.9046 2.3421 8.866
COLO 829 GDSC1 5.3944 8.8625 2.8713 7.1617
VMRC-MELG GDSC1; GDSC2 5.414 6.9222 2.83 0.3194
SK-MEL-28 GDSC1; GDSC2 5.4476 9.2245 2.7336 6.5448
Mel Ho GDSC1; GDSC2 5.5104 10.6327 2.0938 9.8855
WM1552C GDSC1 5.5764 8.723 3.0584 5.5275
A2058 GDSC1 5.6639 7.9682 3.4585 2.8589
LB373-MEL-D GDSC1; GDSC2 5.6738 6.9644 3.8861 0.5111
MeWo GDSC1 5.6984 7.9149 3.5014 2.5499
MZ-MEL-2 GDSC1; GDSC2 5.7941 8.5832 3.2572 3.1567
451Lu GDSC1; GDSC2 5.8246 7.9132 3.5699 1.6225
A101D GDSC1 5.8323 10.6017 2.3341 9.5683
RPMI-7951 GDSC1 6.0357 7.651 3.7775 0.7576
RVH-421 GDSC1; GDSC2 6.1331 12.7844 1.4885 11.6919
HMV-II GDSC1 6.1672 9.0456 3.2628 3.1799
WM35 GDSC1 6.2288 8.132 2.7066 0.3711
DJM-1 GDSC1; GDSC2 6.4024 8.3191 3.678 0.7009
SK-MEL-5 GDSC1; GDSC2 6.4531 11.3155 2.4014 6.4716
SH-4 GDSC1 6.5829 8.8249 3.5605 1.1734
GAK GDSC1 7.0357 15.5692 0.7676 15.3524
UACC-62 GDSC1 7.7757 14.6374 1.6792 9.2813
EquiPSC Line K2 GDSC1; GDSC2 4.4429 6.5927 2.4994 2.7107
⏷ Show the Full List of 57 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1; GDSC2 1.8809 3.6136 1.8126 22.5803
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Rh41 GDSC1 1.4334 2.854 1.4188 32.1756
MES-SA GDSC1 1.8875 3.8825 1.771 27.7099
TE 441.T GDSC1; GDSC2 1.9239 5.8326 1.1796 25.485
G-402 GDSC1 2.1075 6.8983 0.9195 31.038
A-204 GDSC1 2.2829 3.9988 2.1758 23.2701
KYM-1 GDSC1 2.6579 4.7281 2.3808 20.1371
EW-8 GDSC1 3.0946 6.3125 2.1818 19.4055
VA-ES-BJ GDSC1 3.3257 11.704 -0.229 30.3637
Rh30 GDSC1 3.4291 6.2269 2.5516 15.5948
SW982 GDSC1 3.7902 9.2985 1.3778 21.4829
G-401 GDSC1 3.8145 6.2511 2.9076 11.6736
Hs 633.T GDSC1 4.0293 6.9988 2.7324 12.0987
SK-LMS-1 GDSC1 4.8845 7.3591 3.2429 5.9321
STS-0421 GDSC1; GDSC2 4.9085 9.3742 1.494 7.6227
GCT GDSC1 5.4568 8.5203 3.0765 5.6716
MFH-ino GDSC1 5.4786 9.4428 2.6496 8.4105
SW872 GDSC1 5.5024 8.1629 3.2734 4.3032
SW684 GDSC1 5.6166 6.9745 3.8567 0.7969
HT-1080 GDSC1 5.8814 8.6141 3.294 3.4666
RKN GDSC1 6.0437 9.3841 3.041 4.7036
Rh18 GDSC1 6.7292 7.943 3.9355 0.0781
SK-UT-1 GDSC1 6.9053 10.4812 3.0354 3.3495
RD GDSC1 7.1457 9.8915 3.3921 1.3777
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Fu97 GDSC1 1.3179 7.7221 -0.2519 39.3639
OCUM-1 GDSC1 1.3353 5.1785 0.7941 39.7653
MKN45 GDSC1 1.8655 4.667 1.5396 29.1359
RERF-GC-1B GDSC1 2.0252 5.691 1.3433 29.3615
ECC12 GDSC2 2.4237 4.4277 1.9148 11.9184
ECC10 GDSC1 2.6647 7.2514 1.3202 26.3873
KATO III GDSC1 3.4197 6.4609 2.4314 16.4308
NUGC-4 GDSC1 3.9115 6.8871 2.6831 12.856
NCI-N87 GDSC1 4.1418 8.9656 1.8483 17.4945
GCIY GDSC1 4.1958 9.3605 1.6968 20.1512
MKN1 GDSC1 4.5143 7.8417 1.9618 7.0554
NUGC-3 GDSC1 4.5694 9.7592 1.8066 16.3344
23132/87 GDSC1 4.6774 7.6392 2.9494 8.522
TMK-1 GDSC1; GDSC2 5.0152 7.5043 2.4163 2.3004
SK-GT-2 GDSC1 5.0882 7.6999 2.3706 3.0268
RF-48 GDSC1 5.1409 9.0552 2.5982 9.6094
TGBC11TKB GDSC1 5.1566 9.3647 2.4578 10.4893
SNU-5 GDSC1 5.806 11.8578 1.7078 13.3925
SNU-1 GDSC1 5.8962 8.8129 3.2131 3.9265
SCH GDSC1; GDSC2 6.0251 7.5094 3.8271 0.4763
IM95 GDSC1 6.0393 11.7691 1.9142 11.6148
MKN7 GDSC1; GDSC2 6.1647 8.2826 3.5851 1.2119
HSC-39 GDSC1 6.2586 11.9422 1.9798 10.7154
MKN28 GDSC1 6.5076 15.3764 0.4934 19.2478
AGS GDSC1 6.5915 15.2534 0.6127 18.4724
Hs 746.T GDSC1 6.6645 8.2736 3.7995 0.3255
HGC-27 GDSC1 6.7921 18.1213 -0.6431 21.7341
SNU-16 GDSC1 7.0337 14.4704 1.2907 12.7782
SNG-M GDSC1 6.8176 8.4801 3.7836 0.305
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IHH-4 GDSC1 2.864 6.2395 1.9832 21.6593
FTC-133 GDSC1 4.3963 8.3069 1.6581 9.5685
ML-1 [Human leukemia] GDSC1; GDSC2 4.6887 7.4559 3.0492 6.4085
WRO GDSC1 4.6984 7.1963 2.376 3.7024
8505C GDSC1 4.9982 8.0742 2.9752 7.4586
KMH-2 GDSC1; GDSC2 5.1847 7.5675 3.3496 3.6838
ASH-3 GDSC1 5.1994 8.2267 3.0436 6.4877
CAL-62 GDSC1 5.3265 8.4015 3.0464 6.1657
TT GDSC1 5.7051 8.4723 3.2548 4.0232
TT2609-C02 GDSC1 5.8613 9.1063 3.0584 4.9433
8305C GDSC1 6.1416 11.1858 2.2623 9.2965
B-CPAP GDSC1 6.2612 11.8907 2.0061 10.5552
BHT-101 GDSC1 6.6152 8.6103 3.6569 0.7765
K5 GDSC1 6.6254 8.5139 3.6972 0.6333
HTC-C3 GDSC1 6.7809 8.8344 3.6411 0.722
CGTH-W-1 GDSC1 7.1948 14.2251 1.5109 11.291
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 41 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SAT [Human HNSCC] GDSC1 2.1894 4.724 1.8736 28.6766
JHU-022 GDSC1 2.6951 6.9839 1.4743 25.4113
DOK GDSC1 3.1314 4.7407 2.8883 14.6899
PCI-06A GDSC1; GDSC2 3.3929 5.0852 3.0316 10.3115
HSC-2 GDSC1 3.6029 6.2089 2.7282 13.713
PCI-38 GDSC1 3.7024 6.1422 2.8551 12.4618
SCC-25 GDSC1; GDSC2 3.9909 7.2502 2.5735 10.9602
LB771-HNC GDSC1 4.0493 6.0522 3.2203 8.6468
PE/CA-PJ15 GDSC1; GDSC2 4.3155 6.1196 3.4178 5.2194
JHU-029 GDSC1; GDSC2 4.3732 7.1015 2.2201 4.4447
SCC-9 GDSC1 4.408 7.5975 2.7554 10.6774
PCI-15A GDSC1; GDSC2 4.4458 7.9612 2.6045 9.5455
Detroit 562 GDSC1 4.5341 8.2539 2.5298 11.8155
PCI-04B GDSC1; GDSC2 4.5968 7.0383 3.1855 5.8478
SCC-15 GDSC1 4.7233 9.9266 1.8467 15.6109
BICR 78 GDSC1 4.7238 9.3809 2.1191 13.9196
BHY GDSC1; GDSC2 4.8894 8.3536 2.7572 7.6011
FaDu GDSC1 4.8945 8.2219 2.8262 8.7504
Ca9-22 GDSC1 5.0344 9.3331 2.3825 11.3163
CAL-33 GDSC1 5.1565 9.0965 2.5894 9.6259
JHU-011 GDSC1; GDSC2 5.1917 7.5321 3.3709 3.5553
HO-1-u-1 GDSC1 5.2242 11.0141 1.6948 15.0333
KON GDSC1; GDSC2 5.2795 8.0456 3.1849 4.4021
SCC-4 GDSC1 5.5761 7.0824 2.8341 0.314
OSC-20 GDSC1 5.6432 11.1136 1.9544 12.362
OSC-19 GDSC1; GDSC2 5.747 8.5299 3.2535 3.2465
CAL-27 GDSC1 5.7483 10.86 2.1518 10.898
HSC-4 GDSC1 5.9357 9.6835 2.837 6.1798
UPCI-SCC-090 GDSC1 5.9365 7.989 2.6464 0.6899
SKN-3 GDSC1 6.0106 11.6421 1.9556 11.4395
NCI-H3118 GDSC1 6.062 12.1712 1.7358 12.5927
BICR 31 GDSC1; GDSC2 6.0846 10.8817 2.3691 7.285
BB30-HNC GDSC1; GDSC2 6.0864 8.7625 3.3425 2.343
HSC-3 GDSC1 6.1508 10.6272 2.532 7.6268
SAS GDSC1 6.2238 13.8916 1.0146 16.0637
BICR 10 GDSC1 6.2767 8.6156 3.5025 1.749
BICR 22 GDSC1 6.3656 7.8257 3.8461 0.3334
BB49-HNC GDSC1 6.8241 9.274 3.4915 1.2481
PCI-30 GDSC1 6.8589 8.4408 3.8123 0.2325
KOSC-2 GDSC1; GDSC2 6.9031 13.912 1.4697 10.2999
HO-1-N-1 GDSC1 6.915 8.4752 3.8206 0.2021
⏷ Show the Full List of 41 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HT-1197 GDSC1 3.4887 5.2889 3.0428 12.0677
CAL-29 GDSC1 3.4954 5.7166 2.8557 13.2874
RT-4 GDSC1 4.0431 5.795 3.3418 7.8241
UM-UC-3 GDSC1 4.1317 6.6429 2.9994 9.8969
RT-112 GDSC1 4.1411 5.0515 3.7973 4.3046
KU-19-19 GDSC1 4.8637 6.9373 3.4336 4.684
J82 GDSC1 4.9636 6.5076 3.7064 2.634
BFTC-905 GDSC1 4.9898 9.2668 2.3816 11.4477
639V GDSC1 5.1232 8.5708 2.8227 8.1609
SW1710 GDSC1 5.1557 8.5712 2.8457 7.9228
647V GDSC1 5.1791 7.9395 3.168 5.7054
TCCSUP GDSC1 5.5182 7.3658 3.6434 2.018
HT-1376 GDSC1 6.5534 8.919 3.51 1.4177
T24 GDSC1; GDSC2 6.6789 8.5212 3.7159 0.4466
SW780 GDSC1 6.7788 8.4359 3.7848 0.3163
5637 GDSC1 6.8882 8.5699 3.7782 0.2923
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TC-YIK GDSC1 0.1721 2.0882 0.1573 46.1543
C-33 A GDSC1 1.7535 3.6206 1.6746 28.9818
SW954 GDSC1; GDSC2 2.1143 2.9612 2.1118 20.1444
KGN GDSC1 2.1186 5.427 1.5458 27.7819
JAR GDSC1; GDSC2 3.0189 6.3099 2.1073 16.6418
CAL-39 GDSC1 3.4122 5.3395 2.9421 13.0646
NEC8 GDSC1 3.5997 4.6219 3.4355 9.0172
C-4-I GDSC1 4.0779 6.2976 3.124 9.216
JHOS-3 GDSC1; GDSC2 4.0881 6.0902 3.236 6.8949
SW756 GDSC1 4.1421 6.3023 3.1782 8.6147
SKG-IIIa GDSC1 4.2438 6.7066 3.0639 9.0698
OV17R GDSC1; GDSC2 4.3822 5.5945 3.7351 3.2205
JEG-3 GDSC1; GDSC2 4.4131 9.3501 1.8834 13.6435
OVMIU GDSC1 4.4365 6.4195 3.367 6.3341
OVCA420 GDSC1 4.4859 6.0094 3.6106 4.483
OMC-1 [Human cervical carcinoma] GDSC1; GDSC2 4.5396 6.7121 3.303 5.3125
DSH1 GDSC1 4.5735 9.7825 1.7984 16.371
HEY GDSC1 4.6071 7.4372 2.9951 8.4125
UWB1.289 GDSC1; GDSC2 4.7471 7.2067 3.2167 5.3202
PWR-1E GDSC1 4.7933 7.9656 2.8764 8.6912
PA-1 GDSC1 4.8318 7.5752 3.0982 7.9372
DoTc2 4510 GDSC1 4.8869 7.1833 3.3304 5.328
NCC-IT GDSC1 5.0101 7.8907 3.0735 7.5941
HT-3 GDSC1 5.1677 8.1576 3.055 6.4889
Ca Ski GDSC1 5.2123 8.1313 3.0985 6.0899
PEO1 GDSC1 5.3329 7.9053 3.2865 4.5741
BPH-1 GDSC1 5.3861 8.2374 3.1642 5.2555
MS751 GDSC1 5.601 9.0134 2.9374 6.2554
HEC-1 GDSC1 5.6759 7.8414 3.5213 2.4709
SW962 GDSC1; GDSC2 5.9592 8.6928 3.303 2.6956
SKN GDSC1 6.0527 10.0408 2.744 6.5195
NT2-D1 GDSC1 6.1972 8.5273 3.5 1.8558
SiHa GDSC1 6.247 7.4605 3.9307 0.1852
SiSo GDSC1 6.3188 8.3823 3.6166 1.1756
LB831-BLC GDSC1 6.4334 8.1281 3.7627 0.5375
ME-180 GDSC1 6.678 10.2798 3.0017 3.8644
OVCA433 GDSC1; GDSC2 6.7187 8.7383 3.6516 0.5961
HeLa GDSC1 7.1627 15.8004 0.7427 15.1882
ACC-OV7 GDSC1; GDSC2 7.3593 10.2678 3.3393 1.1591
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6049).
2 Synthesis and biological evaluation of 2-pyridyl-substituted pyrazoles and imidazoles as transforming growth factor-beta type 1 receptor kinase inhibitors, Bioorg. Med. Chem. Lett. 20(14):4228-4232 (2010).