Details of the Drug

General Information of Drug (ID: DM4RFT8)

• Drug Name: Amifloxacin
• Synonyms: AMIFLOXACIN; 86393-37-5; UNII-5TU5227KYQ; Win49375; WIN-49375; 5TU5227KYQ; 6-Fluoro-1,4-dihydro-1-(methylamino)-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; Amifloxacino; Amifloxacine; Amifloxacinum; Win-493753; Amifloxacinum [Latin]; Amifloxacine [French]; Amifloxacino [Spanish]; Amifloxacin [USAN:INN:BAN]; Win 49375; EINECS 289-231-8; Amifloxacin (USAN/INN); CHEMBL6231; SCHEMBL48001; ZINC917; AC1L1J77; CTK3E8601; DTXSID20235519; Win 49,375; RUXPNBWPIRDVTH-UHFFFAOYSA-N; HY-U00221; AKOS030530713; CS-7366; FT-0711169
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 334.35
  Logarithm of the Partition Coefficient (xlogp); 0.2
  Rotatable Bond Count (rotbonds); 3
  Hydrogen Bond Donor Count (hbonddonor); 2
  Hydrogen Bond Acceptor Count (hbondacc); 8
• Chemical Identifiers:
  Formula: C16H19FN4O3
  IUPAC Name: 6-fluoro-1-(methylamino)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
  Canonical SMILES: CNN1C=C(C(=O)C2=CC(=C(C=C21)N3CCN(CC3)C)F)C(=O)O
  InChI: InChI=1S/C16H19FN4O3/c1-18-21-9-11(16(23)24)15(22)10-7-12(17)14(8-13(10)21)20-5-3-19(2)4-6-20/h7-9,18H,3-6H2,1-2H3,(H,23,24)
  InChIKey: RUXPNBWPIRDVTH-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 55492
  CAS Number: 86393-37-5
  TTD ID: D04MRV

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
DNA topoisomerase II (TOP2)	TT0IHXV	TOP2A_HUMAN ; TOP2B_HUMAN	Inhibitor	[1]

References

• [1] Activity of fluoroquinolone antibiotics against Plasmodium falciparum in vitro. Antimicrob Agents Chemother. 1988 Aug;32(8):1182-6.