Details of the Drug

General Information of Drug (ID: DM4T5DY)

Drug Name
FGIN-1-27
Synonyms
FGIN-1-27; 142720-24-9; N,N-Dihexyl-2-(4-fluorophenyl)indole-3-acetamide; Fgin 1 27; Fgin 1-27; N,N-Di-n-hexyl-2-(4-fluorophenyl)indole-3-acetamide; CHEMBL63154; 1H-Indole-3-acetamide, 2-(4-fluorophenyl)-N,N-dihexyl-; 2-(2-(4-fluorophenyl)-1H-indol-3-yl)-N,N-dihexylacetamide; 2-[2-(4-fluorophenyl)-1H-indol-3-yl]-N,N-dihexylacetamide; SR-01000075838; Tocris-0658; Lopac-D-8555; Biomol-NT_000279; Lopac0_000453; MLS002153299; SCHEMBL1229718; BPBio1_001277; AC1L313J; FGIN1-27; CHEBI:92171; CTK8E7869; DTXSID90162141
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 2 Molecular Weight (mw) 436.6
Logarithm of the Partition Coefficient (xlogp) 7.9
Rotatable Bond Count (rotbonds) 13
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 2
Chemical Identifiers
Formula
C28H37FN2O
IUPAC Name
2-[2-(4-fluorophenyl)-1H-indol-3-yl]-N,N-dihexylacetamide
Canonical SMILES
CCCCCCN(CCCCCC)C(=O)CC1=C(NC2=CC=CC=C21)C3=CC=C(C=C3)F
InChI
InChI=1S/C28H37FN2O/c1-3-5-7-11-19-31(20-12-8-6-4-2)27(32)21-25-24-13-9-10-14-26(24)30-28(25)22-15-17-23(29)18-16-22/h9-10,13-18,30H,3-8,11-12,19-21H2,1-2H3
InChIKey
VUWXAQFLTSBUDB-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
132496
ChEBI ID
CHEBI:92171
CAS Number
142720-24-9
TTD ID
D0A0ED

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Translocator protein (TSPO) TTPTXIN TSPO_HUMAN Binder [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [2]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [2]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [2]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [2]
Cytochrome P450 2B6 (CYP2B6) OTOYO4S7 CP2B6_HUMAN Gene/Protein Processing [3]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Gene/Protein Processing [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MHH-NB-11 CTRP2 7.2791 8.7373 4.573 0.1499
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuH-28 CTRP2 6.5537 7.9335 4.5814 0.362
SNU-478 CTRP2 6.8626 9.1816 4.2226 1.1553
SNU-1196 CTRP2 7.0197 8.7588 4.4638 0.4178
SNU-1079 CTRP2 7.4722 9.7366 4.2823 0.6219
SNU-308 CTRP2 7.5253 9.0482 4.5544 0.127
HuCC-T1 CTRP2 7.6477 9.216 4.5404 0.1223
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U2OS CTRP1 6.6129 9.7425 3.8505 5.8426
SW1353 CTRP2 7.4884 8.8968 4.5931 0.0933
MHH-ES-1 CTRP2 7.8723 9.9275 4.3736 0.296
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MCF-7 CTRP2; CTRP1 5.1157 7.5448 3.863 4.9134
HCC1569 CTRP2 5.2341 7.9514 3.7458 5.103
KPL-1 CTRP2 5.6872 9.6729 3.2416 6.422
HDQ-P1 CTRP2 6.5213 9.0369 4.1032 1.8548
HMC-1-8 CTRP2 6.6563 7.5378 4.7627 0.0477
JIMT-1 CTRP2 6.6764 8.3302 4.4808 0.5431
HCC1806 CTRP2 6.8957 9.1004 4.2726 0.9809
CAL-148 CTRP2 7.1782 8.4262 4.6441 0.0874
CAL-120 CTRP2 7.2481 8.6449 4.5939 0.1302
HCC1937 CTRP2 7.2814 9.1953 4.4078 0.4288
HCC1395 CTRP2 7.3596 9.1891 4.4418 0.3337
CAMA-1 CTRP2 7.3963 8.7247 4.6192 0.0815
CAL-51 CTRP2 7.6623 9.2523 4.5332 0.1277
HCC1954 CTRP2 9.1506 20.5879 0.3707 12.1194
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 6.6681 7.7884 4.6806 0.1377
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LN-229 CTRP2; CTRP1 4.9073 6.8561 4.0311 4.6174
SNU-626 CTRP2 5.3226 7.7445 3.9186 4.2217
GaMG CTRP1 5.6618 8.4451 3.8382 8.6988
GB-1 CTRP2 5.9651 9.6511 3.4559 5.0947
SNU-738 CTRP2 6.0667 8.7537 3.9569 2.9335
SNU-466 CTRP2 6.2509 7.8393 4.4782 0.8314
SNU-1105 CTRP2 6.6004 7.6627 4.6997 0.1264
Daoy CTRP2 6.6204 9.3477 4.0209 2.0471
SF126 CTRP2 6.6359 9.25 4.073 1.8474
SF295 CTRP2 6.671 8.173 4.5396 0.4033
SNU-201 CTRP2 6.6804 8.9654 4.221 1.3057
LN-18 CTRP2 6.9072 7.9451 4.7124 0.0604
ONS-76 CTRP2 6.9679 8.8906 4.3906 0.6136
U-87MG ATCC CTRP2 7.1133 8.2713 4.6739 0.0686
CAS-1 CTRP2 7.1328 8.4957 4.6038 0.1402
NMC-G1 CTRP2 7.7104 9.0858 4.6061 0.0586
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HEC-151 CTRP1 4.0567 6.5438 3.3757 19.8212
KLE CTRP2; CTRP1 5.0055 9.9524 2.5675 10.5461
JHUEM-2 CTRP2; CTRP1 5.0068 6.7983 4.1454 3.9375
HEC-108 CTRP2; CTRP1 5.2639 6.5902 4.4566 2.1602
HEC-59 CTRP2; CTRP1 5.4302 6.9139 4.4197 2.0472
HEC-265 CTRP2 6.0641 7.3785 4.5777 0.6658
RL95-2 CTRP2 6.7812 8.1326 4.6001 0.2363
HEC-6 CTRP2 7.1022 8.2094 4.6909 0.0561
HEC-251 CTRP2 7.3229 8.766 4.579 0.1342
HEC-1-B CTRP2 7.6686 9.1794 4.5603 0.0997
Ishikawa (Heraklio) 02 ER- CTRP2; CTRP1 5.1649 6.5971 4.3762 2.6686
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 51 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BL-70 CTRP1 4.071 4.8602 4.0278 14.43
PL21 CTRP1 4.0942 6.3482 3.5021 18.5719
THP-1 CTRP1 4.3521 6.1851 3.8357 14.3414
GDM-1 CTRP1 4.3616 5.8189 4.0101 12.8
OCI-AML-3 CTRP1 4.6346 6.7132 3.8561 12.7222
LP-1 CTRP1 4.8282 6.051 4.3595 7.3282
U-937 CTRP1 4.9509 7.6453 3.6746 12.868
SKM-1 CTRP1 5.0087 6.4409 4.3256 6.8194
NOMO-1 CTRP1 5.0166 6.5339 4.2858 7.1441
SU-DHL-5 CTRP1 5.0499 6.1991 4.4812 5.2441
RPMI-8226 CTRP1 5.0889 7.0417 4.0924 8.5831
WSU-DLCL2 CTRP2; CTRP1 5.1048 6.3187 4.4668 2.399
KMS-11 CTRP1 5.2028 8.4918 3.4608 13.6389
MOLM-16 CTRP1 5.3343 6.8934 4.3598 5.2485
NU-DUL-1 CTRP1 5.3709 8.8771 3.4032 13.4487
DEL CTRP2 5.4647 7.3843 4.2035 2.8013
EJM CTRP1 5.6758 7.3716 4.3674 4.093
AMO1 CTRP1 5.6793 7.2837 4.4113 3.7126
KE-37 CTRP2 5.8266 9.0499 3.6502 4.512
KMS-26 CTRP2 6.2095 7.2767 4.6862 0.2812
SU-DHL-1 CTRP2 6.2154 7.1348 4.7418 0.1648
EM-2 CTRP2 6.5374 8.6513 4.2806 1.2317
SU-DHL-4 CTRP1 6.5401 7.7549 4.657 0.5243
KMM-1 CTRP2 6.5514 9.4355 3.9413 2.4095
KMS-27 CTRP2 6.5676 9.9752 3.7032 3.2863
P31/FUJ CTRP2 6.6402 7.6487 4.7192 0.0931
KHM-1B CTRP2 6.7249 8.415 4.4691 0.5465
HEL CTRP2 6.8322 8.0433 4.6517 0.1406
KE-97 CTRP2 6.845 7.9854 4.6766 0.106
MOLM-13 CTRP2 6.851 8.579 4.4607 0.5019
KMS-21-BM CTRP2 6.8774 8.7106 4.421 0.5858
JVM-3 CTRP2 6.8824 9.299 4.1832 1.2623
KM-H2 CTRP2 6.8865 8.4079 4.5406 0.3118
HT CTRP2 6.9177 8.0745 4.672 0.0985
Peer CTRP2 7.0099 8.361 4.6057 0.1643
P12-Ichikawa CTRP2 7.0301 8.446 4.5831 0.1926
NALM-6 CTRP2 7.0843 8.6924 4.5149 0.2914
KCL-22 CTRP2 7.1307 9.1072 4.3777 0.5622
JURL-MK1 CTRP2 7.236 8.8537 4.5156 0.2438
CML-T1 CTRP2 7.4023 8.7244 4.6214 0.0789
LAMA-84 CTRP2 7.5262 9.2067 4.4995 0.1948
RPMI-8402 CTRP2 7.5495 8.9617 4.5924 0.086
NCI-H929 CTRP2 7.6588 9.108 4.581 0.0827
Jurkat CTRP2 7.6907 9.0421 4.6139 0.0551
PF-382 CTRP2 7.7019 9.1913 4.5678 0.0887
MV4-11 CTRP2 7.7201 9.2998 4.5374 0.1145
EHEB CTRP2 7.7387 9.4853 4.4801 0.1756
Ku812 CTRP2 7.8391 9.5351 4.4991 0.1358
Ki-JK CTRP2 7.8881 9.3065 4.593 0.0522
HDLM-2 CTRP2 7.9593 9.8599 4.4301 0.1949
OCI-Ly10 CTRP1 8.1768 10.2146 4.4001 0.4513
⏷ Show the Full List of 51 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RCC10RGB CTRP1 4.6633 5.7073 4.3659 8.103
TUHR4TKB CTRP2 5.4629 7.9692 3.9144 4.0006
769-P CTRP2 6.7822 9.9126 3.8606 2.4559
KMRC-20 CTRP2 6.9476 9.5567 4.1074 1.4511
SNU-1272 CTRP2 7.1026 8.5806 4.5625 0.2054
BFTC-909 CTRP2 7.2361 8.6761 4.5787 0.1514
OS-RC-2 CTRP2 7.3793 9.0296 4.5072 0.2186
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 35 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-C4 CTRP1 4.3624 6.4294 3.7322 15.1749
SW948 CTRP1 4.5101 6.8055 3.6946 14.7423
SW480 CTRP1 4.8092 7.2895 3.7292 13.0193
CW-2 CTRP1 4.8882 6.8523 4.0163 10.1221
LS180 CTRP2; CTRP1 4.9456 6.6123 4.1858 3.8907
SNU-C5 CTRP1 4.9483 6.8454 4.0719 9.3604
SW620 CTRP1 5.0285 7.1699 3.9779 9.8585
HT115 CTRP2; CTRP1 5.0532 6.8657 4.1508 3.8242
CL-34 CTRP1 5.0701 6.4168 4.3892 5.9896
NCI-H508 CTRP1 5.1442 6.5855 4.3655 5.9052
RCM-1 [Human ESC] CTRP1 5.2086 7.7273 3.8473 10.2849
CL-40 CTRP1 5.237 6.9806 4.2422 6.6552
KM12 CTRP1 5.246 7.5038 3.9886 8.8857
SNU-81 CTRP1 5.3134 8.0404 3.7746 10.5135
COLO 320 CTRP1 5.3432 8.1981 2.9366 6.7719
LoVo CTRP1 5.3491 8.7062 3.4711 12.9703
SNU-1040 CTRP1 5.3571 6.6289 4.5064 3.8726
COLO 678 CTRP1 5.4115 7.0306 4.3492 5.0762
SNU-61 CTRP1 5.4124 7.5888 4.0751 7.4991
HT-55 CTRP1 5.754 7.5178 4.3493 4.0254
HCT 8 CTRP1 5.7555 7.0607 4.5617 2.2884
HT-29 CTRP2; CTRP1 5.8235 7.2465 4.5175 1.1542
SNU-175 CTRP2; CTRP1 6.0541 11.8381 2.4587 9.1036
HCT 116 CTRP2; CTRP1 6.1513 7.8487 4.4348 1.1192
SW48 CTRP2 6.1753 8.5508 4.12 2.1686
RKO CTRP1 6.3069 8.1129 4.4037 2.3253
LS123 CTRP1 6.3654 9.0187 4.0328 5.0172
OUMS-23 CTRP2 6.4631 7.7894 4.5979 0.3662
MDST8 CTRP1 6.4947 7.9983 4.5438 1.1313
DLD-1 CTRP2 6.5188 7.5199 4.7197 0.1171
LS411N CTRP2 6.5357 7.7665 4.6369 0.2517
LS513 CTRP2 6.9045 12.0573 2.9406 5.8195
COLO205 CTRP2 6.9262 7.997 4.7015 0.0676
SK-CO-1 CTRP2 7.4131 9.1023 4.4941 0.2299
SNU-C2A CTRP2 10.2941 28.8288 -2.8079 19.2727
⏷ Show the Full List of 35 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-449 CTRP1 4.7169 7.1852 3.6989 13.7075
SNU-398 CTRP1 5.0442 6.6712 4.2405 7.4366
JHH-6 CTRP1 6.2193 6.9533 4.8222 0.1457
SNU-182 CTRP2 6.7168 9.5957 3.9651 2.1483
Hep-G2 CTRP1 6.8123 8.3996 4.5269 0.8731
Hep 3B2.1-7 CTRP2 7.2072 8.6375 4.5815 0.1536
Li-7 CTRP2 7.435 9.2428 4.4519 0.292
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 81 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H211 CTRP2 3.9648 8.2838 2.4558 13.1501
LXF 289 CTRP1 4.0396 6.3659 3.4389 19.398
NCI-H1581 CTRP2 4.102 5.5629 3.8392 7.2395
NCI-H2286 CTRP1 4.2865 6.0751 3.8197 14.8331
NCI-H1963 CTRP1 4.3315 5.9162 3.9364 13.5936
SCLC-21H CTRP1 4.4854 5.8742 4.1114 11.2531
NCI-H1435 CTRP1 4.505 6.0306 4.0591 11.5984
NCI-H2106 CTRP2 4.5069 7.002 3.5881 7.2444
NCI-H1105 CTRP1 4.5154 11.8108 1.22 30.5765
T3M-10 CTRP1 4.6804 6.2176 4.1402 9.992
NCI-H2342 CTRP1 4.7295 7.5059 3.5511 14.9266
NCI-H2122 CTRP1 4.7303 6.5028 4.0476 10.5698
RERF-LC-KJ CTRP1 4.7833 6.7973 3.9506 11.1824
NCI-H841 CTRP1 4.8584 7.8391 3.4984 14.789
COR-L51 CTRP1 4.8614 9.5535 2.6449 21.3527
COLO 668 CTRP1 4.9603 7.0576 3.9763 10.1631
NCI-H1836 CTRP1 5.0523 7.9524 3.6066 13.0232
NCI-H596 CTRP1 5.0698 7.0453 4.0748 8.8197
NCI-H1930 CTRP1 5.0949 6.9885 4.1239 8.2751
NCI-H1155 CTRP2 5.1527 7.4016 3.9548 4.3753
HCC1833 CTRP2; CTRP1 5.1946 6.7883 4.3045 2.9156
NCI-H2141 CTRP1 5.2307 6.4208 4.5153 4.2332
HCC4006 CTRP1 5.247 6.6028 4.4375 4.8683
NCI-H441 CTRP1 5.2648 8.1356 3.6886 11.4494
NCI-H1876 CTRP1 5.3618 7.1139 4.2716 5.9354
NCI-H1694 CTRP1 5.3814 6.9135 4.3847 4.8652
NCI-H2073 CTRP1 5.4828 7.0632 4.3843 4.5338
NCI-H2110 CTRP1 5.4876 7.9853 3.9358 8.4577
NCI-H3255 CTRP1 5.4907 7.2847 4.2821 5.4022
HCC15 CTRP2; CTRP1 5.5985 8.3528 3.8372 4.1788
NCI-H2172 CTRP1 5.6649 7.7443 4.1815 5.7197
HCC2935 CTRP1 5.6824 8.3728 3.8885 8.1974
NCI-H1755 CTRP1 5.7071 7.6942 4.2344 5.1352
COLO 699 CTRP2; CTRP1 5.8332 8.3656 3.9979 3.1652
NCI-H2030 CTRP2; CTRP1 5.8531 7.6855 4.3337 1.8111
NCI-H358 CTRP2 5.8767 8.3291 4.0332 2.8869
DMS 79 CTRP2 5.8853 9.3692 3.5364 4.8876
NCI-H1781 CTRP1 5.9129 7.6914 4.3679 3.454
NCI-H2009 CTRP2; CTRP1 5.9332 8.1334 4.1749 2.3258
Calu-3 CTRP2 5.9678 13.4713 1.5736 12.6879
NCI-H1915 CTRP1 5.9869 7.8666 4.3323 3.5572
SK-LU-1 CTRP1 6.0325 8.5955 4.0213 5.989
Lu-99 CTRP2 6.0525 7.9629 4.3151 1.5802
RERF-LC-Ad1 CTRP2 6.1358 15.412 0.7397 15.4805
HCC1195 CTRP1 6.1581 8.2431 4.2628 3.6991
RERF-LC-A1 CTRP2 6.1787 9.2507 3.7948 3.4241
HCC1359 CTRP1 6.2197 7.2388 4.7188 0.5212
NCI-H2023 CTRP1 6.2423 10.812 3.099 12.7523
MOR/CPR CTRP2 6.2971 7.0666 4.7968 0.0643
HARA [Human squamous cell lung carcinoma] CTRP2 6.3104 9.1115 3.9441 2.6763
Sq-1 CTRP1 6.318 8.3715 4.2968 3.0835
HCC2108 CTRP2; CTRP1 6.3225 8.9439 4.0412 2.3638
SBC-5 CTRP2 6.3448 7.4785 4.6664 0.2659
NCI-H1734 CTRP2 6.4665 10.7786 3.2584 5.1625
HCC827 CTRP2; CTRP1 6.4714 9.0691 4.0727 2.0814
NCI-H1975 CTRP2 6.4843 8.6878 4.2366 1.4259
SHP-77 CTRP2 6.5195 8.2274 4.4494 0.7233
HCC1588 CTRP2 6.539 8.619 4.2953 1.1825
BEN CTRP2 6.5624 7.6233 4.6994 0.1358
LCLC-103H CTRP2 6.6393 7.9839 4.598 0.2904
HCC44 CTRP2 6.6505 15.4548 1.1095 13.2674
NCI-H1838 CTRP2 6.8832 9.8661 3.9386 2.0764
NCI-H69 CTRP2 6.8899 8.482 4.5143 0.364
NCI-H2081 CTRP1 6.9042 8.6791 4.4589 1.1188
NCI-H460 CTRP2; CTRP1 6.923 7.9993 4.7139 0.0717
NCI-H2291 CTRP2 6.929 8.7073 4.4449 0.5013
COR-L23 CTRP1 6.9695 8.2705 4.6368 0.3292
CAL-12T CTRP2; CTRP1 6.9701 8.4976 4.5551 0.2869
HCC366 CTRP2 7.0097 8.8878 4.4101 0.5445
NCI-H727 CTRP2 7.0787 11.1469 3.4756 3.5471
NCI-H526 CTRP2 7.0911 15.1221 1.5926 10.7751
NCI-H650 CTRP2 7.1131 9.4789 4.222 0.9803
NCI-H292 CTRP2 7.1793 9.0409 4.4237 0.4369
HCC95 CTRP2 7.2003 8.6904 4.5603 0.1843
HCC1171 CTRP2 7.3634 9.824 4.1997 0.8859
NCI-H1299 CTRP2 7.4508 9.5114 4.359 0.4626
NCI-H196 CTRP2 7.4766 9.6409 4.3208 0.5333
HCC78 CTRP2 7.8771 9.4017 4.5576 0.0773
NCI-H2405 CTRP2 8.1926 10.1765 4.4048 0.1813
A-549 CTRP2 8.2186 9.7467 4.5587 0.048
HCC2279 CTRP2 10.3165 21.7094 0.5882 9.9822
⏷ Show the Full List of 81 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 680N CTRP2 6.5007 8.4711 4.3385 1.075
TE-10 CTRP2 6.7368 13.549 2.1067 9.345
TE-9 CTRP2 7.1103 8.9874 4.415 0.4857
KYSE-180 CTRP2 7.3062 11.2983 3.5406 3.0624
KYSE-140 CTRP2 8.2761 10.9006 4.1772 0.5148
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RMUG-S CTRP1 4.1157 7.1766 3.1388 21.395
COV434 CTRP1 4.5595 6.2826 3.9935 11.8881
RMG-I CTRP1 4.7645 7.8241 3.4239 15.8416
OVCAR-4 CTRP1 4.8718 8.3579 3.251 16.7789
Caov-3 CTRP1 4.976 6.3593 4.3383 6.846
OVK18 CTRP1 5.0182 8.6261 3.2413 16.2153
SNU-840 CTRP1 5.0633 8.8389 3.1726 16.5708
JHOS-4 CTRP1 5.1304 7.3375 3.9786 9.4319
OV-90 CTRP1 5.168 7.5557 3.9002 9.9784
SNU-119 CTRP2 5.17 7.1109 4.1139 3.6755
A2780 CTRP1 5.2 6.8463 4.2799 6.4583
TYK-nu CTRP1 5.2989 6.7482 4.4049 4.9724
OVCAR-8 CTRP1 5.3009 7.2418 4.162 7.1329
JHOC-5 CTRP2; CTRP1 5.3736 6.8124 4.4286 2.0982
OVMANA CTRP1 5.7156 7.0765 4.5307 2.631
COV318 CTRP1 5.7159 8.2089 3.9921 7.1932
COV644 CTRP1 5.8399 8.0547 4.1512 5.4509
IGROV-1 CTRP1 5.9644 8.2534 4.1385 5.2037
EFO-27 CTRP1 6.0293 8.3563 4.1317 5.0826
OVKATE CTRP1 6.1351 8.4247 4.1659 4.527
COV362 CTRP1 6.2428 8.7824 4.0669 5.0516
JHOM-1 CTRP1 6.2711 10.6714 3.1874 11.9931
OVISE CTRP2 6.5088 7.9785 4.5443 0.4731
SNU-8 CTRP2 6.7461 7.7541 4.7208 0.0739
ES2 CTRP2 6.7914 7.919 4.6802 0.1118
OAW42 CTRP1 6.8235 7.7785 4.7539 0.1061
ONCO-DG-1 CTRP2 6.8346 8.4891 4.4883 0.4452
DOV13 CTRP2 7.1168 8.678 4.5329 0.2494
OV7 CTRP1 7.146 8.8213 4.5061 0.6833
OVTOKO CTRP2 7.8937 9.8747 4.4005 0.2495
OVSAHO CTRP2 8.0665 10.1446 4.3697 0.2528
Kuramochi CTRP2 11.7512 25.7807 -0.4106 11.3648
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PaTu 8902 CTRP1 4.7669 5.9797 4.3372 7.8228
KP-4 CTRP2 5.085 7.1027 4.0489 4.1068
SNU-213 CTRP2 6.1814 9.5405 3.6587 3.9605
KP-3 CTRP2 6.3018 8.6302 3.2893 0.8796
BxPC-3 CTRP2 6.6932 12.166 2.7464 6.8819
QGP-1 CTRP2 6.9004 8.5421 4.496 0.3987
SUIT-2 CTRP2 6.9346 8.4313 4.5513 0.2745
CFPAC-1 CTRP2 7.7356 9.2373 4.564 0.0879
HPAF-II CTRP2 7.7675 17.2377 1.0409 11.7766
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ACC-MESO-1 CTRP2 6.866 8.2112 4.6046 0.203
NCI-H28 CTRP2 7.5198 9.7298 4.3052 0.5487
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PaCa-3 CTRP1 4.7551 5.9835 4.3242 7.996
22Rv1 CTRP2 10.5412 20.9838 1.0558 8.2395
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-15 CTRP2 7.0667 8.1491 4.6989 0.0537
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hs 852.T CTRP1 4.3086 5.4623 4.1031 12.328
SK-MEL-5 CTRP1 5.4622 7.2702 4.2687 5.6148
SK-MEL-28 CTRP1 5.982 6.8991 4.7473 0.6197
A-375 CTRP2; CTRP1 6.4186 7.7424 4.6105 0.3991
Mel Ho CTRP2 6.7884 8.3928 4.5055 0.4272
SK-MEL-1 CTRP2; CTRP1 6.8112 8.1265 4.6282 0.2078
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RKN CTRP1 5.564 6.9319 4.5025 3.269
Rh41 CTRP2 6.6157 8.5394 4.3677 0.8966
HT-1080 CTRP1 6.6754 8.0686 4.595 0.6816
Cancer Drug Sensitivity Data Curated from 17 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AGS CTRP2; CTRP1 4.8362 6.0091 4.3875 3.2803
MKN74 CTRP1 4.9294 6.8111 4.0726 9.4356
MKN1 CTRP2 5.5719 8.313 3.8262 4.1881
GSU CTRP2 6.046 6.6302 4.8571 0.0405
MKN45 CTRP2 6.2752 7.1138 4.7723 0.0991
SNU-620 CTRP2 6.5588 7.7198 4.6633 0.1949
23132/87 CTRP2 6.626 8.2131 4.5044 0.5107
SNU-668 CTRP2 6.6354 8.9111 4.2206 1.345
SNU-5 CTRP2 6.7455 7.9962 4.6357 0.1863
ECC12 CTRP2 6.8107 7.7962 4.7292 0.0577
GSS CTRP2 7.0813 8.6526 4.5283 0.2683
NCI-N87 CTRP2 7.2643 13.2062 2.6321 6.5394
NUGC-4 CTRP2 7.3036 9.5088 4.2972 0.6694
SNU-719 CTRP2 7.3483 9.4318 4.3462 0.5333
KE-39 CTRP2 8.2778 11.6468 3.8913 1.1702
SNG-M CTRP1 5.5767 8.5433 3.7271 9.9492
SNU-1077 CTRP2 7.6502 9.1092 4.5776 0.0866
⏷ Show the Full List of 17 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
8505C CTRP2 5.8621 9.0431 3.6787 4.3409
CAL-62 CTRP2 6.2647 7.7212 4.5343 0.6504
CGTH-W-1 CTRP2 6.9142 8.2737 4.6006 0.1961
B-CPAP CTRP2 7.0731 8.5369 4.5669 0.2064
BHT-101 CTRP2 7.6345 9.3477 4.49 0.1841
8305C CTRP2 7.6463 9.3397 4.4971 0.1726
TT CTRP2 7.7548 9.4791 4.4881 0.1628
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-46 CTRP2 6.6583 8.8668 4.2515 1.2251
SNU-1076 CTRP2 6.7858 8.1464 4.5968 0.2407
BHY CTRP2 6.8483 9.8427 3.9295 2.1426
HSC-3 CTRP2 7.069 8.292 4.6513 0.0963
YD-10B CTRP2 7.0756 8.5735 4.5547 0.2251
SNU-899 CTRP2 7.0883 9.0678 4.3745 0.5908
Detroit 562 CTRP2 7.2609 8.8215 4.5366 0.2043
SNU-1214 CTRP2 7.2784 9.4278 4.3177 0.6324
SNU-1066 CTRP2 7.4568 8.9526 4.5628 0.1292
SCC-9 CTRP1 7.8965 9.5135 4.541 0.2201
SNU-1041 CTRP2 8.0187 9.499 4.5734 0.054
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-29 CTRP2 5.6999 7.5291 4.2967 2.0801
253J-BV CTRP2 6.1813 8.2302 4.2695 1.6083
5637 CTRP2 6.4067 12.6158 1.5666 7.2729
TCCSUP CTRP2 6.5067 10.4921 3.4216 4.46
253J CTRP2 6.7315 8.5081 4.4352 0.6302
639V CTRP2 6.7533 7.6443 4.7603 0.0397
BFTC-905 CTRP2 6.7737 7.9812 4.6517 0.1542
JMSU-1 CTRP2 6.8439 8.6373 4.4348 0.5689
KU-19-19 CTRP2 6.9656 8.2182 4.6395 0.1284
VM-CUB-1 CTRP2 7.8439 9.2836 4.5857 0.0605
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug

References

1 Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human colorectal cancer cells. Br J Cancer. 2001 Nov 30;85(11):1771-80.
2 Peripheral benzodiazepine receptor ligands induce apoptosis and cell cycle arrest in human hepatocellular carcinoma cells and enhance chemosensitivity to paclitaxel, docetaxel, doxorubicin and the Bcl-2 inhibitor HA14-1. J Hepatol. 2004 Nov;41(5):799-807. doi: 10.1016/j.jhep.2004.07.015.
3 Modulation of constitutive androstane receptor (CAR) and pregnane X receptor (PXR) by 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives, ligands of peripheral benzodiazepine receptor (PBR). Toxicol Lett. 2011 Apr 25;202(2):148-54.