Details of the Drug

General Information of Drug (ID: DM4TGY0)

Drug Name
CGP-60474
Synonyms
CGP60474; 164658-13-3; CGP-60474; UNII-16IP6G5MLC; CGP 60474; GNF-Pf-88; 16IP6G5MLC; 3-[[4-[2-[(3-Chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol; MLS000911536; SMR000463552; 3-[[4-[2-(3-chloroanilino)pyrimidin-4-yl]-2-pyridyl]amino]propan-1-ol; 3-[[4-[2-(3-chloroanilino)pyrimidin-4-yl]pyridin-2-yl]amino]propan-1-ol; 1-Propanol, 3-((4-(2-((3-chlorophenyl)amino)-4-pyrimidinyl)-2-pyridinyl)amino)-; 1-propanol, 3-[[4-[2-[(3-chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-; AC1LD8S6; MLS003105942
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Terminated [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 355.8
Logarithm of the Partition Coefficient (xlogp) 3.8
Rotatable Bond Count (rotbonds) 7
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C18H18ClN5O
IUPAC Name
3-[[4-[2-(3-chloroanilino)pyrimidin-4-yl]pyridin-2-yl]amino]propan-1-ol
Canonical SMILES
C1=CC(=CC(=C1)Cl)NC2=NC=CC(=N2)C3=CC(=NC=C3)NCCCO
InChI
InChI=1S/C18H18ClN5O/c19-14-3-1-4-15(12-14)23-18-22-9-6-16(24-18)13-5-8-21-17(11-13)20-7-2-10-25/h1,3-6,8-9,11-12,25H,2,7,10H2,(H,20,21)(H,22,23,24)
InChIKey
IYNDTACKOAXKBJ-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
644215
ChEBI ID
CHEBI:91339
CAS Number
164658-13-3
TTD ID
D0U2TQ

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cyclin-dependent kinase 1 (CDK1) TTH6V3D CDK1_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Solid tumour/cancer
ICD Disease Classification 2A00-2F9Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Cyclin-dependent kinase 1 (CDK1) DTT CDK1 5.27E-108 1.97 3.12
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 142 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 -4.1684 -3.0868 -4.1795 27.6025
MOLP-8 GDSC1 -6.5184 -4.5437 -6.5297 56.7387
SUP-M2 GDSC1 -6.1461 -5.5293 -6.1461 52.2536
GA-10 GDSC1 -5.7296 -4.5237 -5.7308 47.0518
BL-41 GDSC1 -5.7203 -3.5547 -5.763 47.0367
A3/Kawakami GDSC1 -5.6941 -4.0191 -5.7055 46.6404
697 GDSC1 -5.6558 -4.3056 -5.6589 46.1377
SU-DHL-8 GDSC1 -5.5424 -4.2031 -5.5459 44.7243
SU-DHL-6 GDSC1 -5.5372 -4.4521 -5.5379 44.6464
P32/ISH GDSC1 -5.4155 -4.3804 -5.4161 43.1244
SR GDSC1 -5.4144 -4.4248 -5.4148 43.1098
DEL GDSC1 -5.4143 -3.3495 -5.4611 43.3103
SU-DHL-4 GDSC1 -5.3 -4.1076 -5.3024 41.6916
Karpas-231 GDSC1 -5.2957 -3.84 -5.3044 41.6713
Karpas-299 GDSC1 -5.27 -2.8571 -5.3734 41.7747
A4/Fukuda GDSC1 -5.1539 -4.0286 -5.1559 39.8637
JSC-1 GDSC1 -5.0594 -3.9197 -5.0621 38.6865
Farage GDSC1 -4.9917 -3.6757 -4.9993 37.8696
DoHH2 GDSC1 -4.959 -3.3218 -4.9853 37.5697
Namalwa GDSC1 -4.9081 -3.8936 -4.9096 36.7883
SUP-HD1 GDSC1 -4.9055 -2.1177 -5.1338 37.9459
Jiyoye GDSC1 -4.8996 -3.2527 -4.9289 36.8466
DND-41 GDSC1 -4.8767 -3.5449 -4.8866 36.4469
SIG-M5 GDSC1 -4.7973 -3.9297 -4.7979 35.398
CTV-1 GDSC1 -4.7847 -2.3204 -4.9531 36.191
SCC-3 GDSC1 -4.7539 -3.8159 -4.7552 34.8594
Ku812 GDSC1 -4.7338 -3.6563 -4.7373 34.6221
MV4-11 GDSC1 -4.6503 -3.8158 -4.6509 33.5601
L-363 GDSC1 -4.6267 -3.2474 -4.6445 33.3722
Daudi GDSC1 -4.6262 -2.4242 -4.7581 34.0457
HC-1 GDSC1 -4.6244 -2.3997 -4.7613 34.0525
MOLM-13 GDSC1 -4.6211 -3.2636 -4.6377 33.2941
Ramos.2G6.4C10 GDSC1 -4.5781 -3.5808 -4.581 32.6718
NK-92MI GDSC1 -4.524 -3.324 -4.534 32.0403
HT GDSC1 -4.5143 -2.762 -4.5771 32.2458
MY-M12 GDSC1 -4.5095 -3.1729 -4.5278 31.9102
MC116 GDSC1 -4.4973 -3.6836 -4.4981 31.6492
Raji GDSC1 -4.464 -2.4118 -4.5846 31.974
NALM-6 GDSC1 -4.449 -2.7963 -4.5025 31.3741
OCI-Ly19 GDSC1 -4.4261 -3.2519 -4.4367 30.8199
JJN-3 GDSC1 -4.4232 -3.2063 -4.4362 30.7988
SU-DHL-16 GDSC1 -4.4192 -3.5879 -4.4203 30.6745
Karpas-620 GDSC1 -4.4171 -3.8277 -4.4172 30.6419
WIL2 NS GDSC1 -4.4094 -2.6383 -4.4836 31.0091
QIMR-WIL GDSC1 -4.3916 -2.781 -4.4433 30.6464
CCRF-CEM GDSC1 -4.3594 -3.0987 -4.3768 30.0291
AMO1 GDSC1 -4.2796 -3.4529 -4.2812 28.9333
ATN-1 GDSC1 -4.2738 -1.7927 -4.5339 30.4783
LP-1 GDSC1 -4.2261 -3.0023 -4.245 28.3731
VL51 GDSC1 -4.2175 -2.2059 -4.3619 29.0631
RS4;11 GDSC1 -4.1919 -2.7153 -4.2391 28.1248
NU-DUL-1 GDSC1 -4.1854 -2.9889 -4.2035 27.8592
MHH-PREB-1 GDSC1 -4.1563 -2.0822 -4.3256 28.462
KOPN-8 GDSC1 -4.1523 -2.6936 -4.1998 27.6325
MOLT-4 GDSC1 -4.1355 -3.15 -4.1426 27.1662
PL-21 GDSC1 -4.11 -2.1873 -4.2492 27.6937
RPMI-8866 GDSC1 -4.0552 -3.0783 -4.0632 26.1684
MOLT-16 GDSC1 -4.0084 -3.3233 -4.0093 25.5382
OCI-AML-2 GDSC1 -3.9987 -2.9494 -4.0121 25.4956
SUP-B15 GDSC1 -3.9981 -2.862 -4.018 25.5294
Karpas-422 GDSC1 -3.9825 -2.9045 -3.9984 25.3093
KE-37 GDSC1 -3.9811 -2.5615 -4.0358 25.5394
KCL-22 GDSC1 -3.9365 -2.5324 -3.9925 24.9909
CTB-1 GDSC1 -3.8884 -2.1048 -4.0277 24.9346
DB GDSC1 -3.8839 -1.8359 -4.096 25.3601
BV-173 GDSC1 -3.8016 -2.002 -3.9595 23.976
NB4 GDSC1 -3.8011 -2.8525 -3.8132 23.0174
HH [Human lymphoma] GDSC1 -3.7933 -2.2765 -3.8848 23.4332
LC4-1 GDSC1 -3.7857 -2.4896 -3.8374 23.0789
HEL GDSC1 -3.7623 -2.3502 -3.8364 22.9326
EJM GDSC1 -3.7419 -2.6636 -3.7675 22.3637
Loucy GDSC1 -3.7364 -2.4457 -3.7914 22.4848
RPMI-8402 GDSC1 -3.711 -2.4495 -3.7635 22.1505
BC-3 GDSC1 -3.6702 -1.8159 -3.8688 22.6131
ALL-PO GDSC1 -3.6699 -1.6625 -3.9164 22.9339
L-540 GDSC1 -3.6531 -2.119 -3.7677 21.8361
KY821 GDSC1 -3.6496 -1.7624 -3.8627 22.4553
NKM-1 GDSC1 -3.6435 -1.4012 -3.9769 23.1988
ARH-77 GDSC1 -3.6429 -1.2332 -4.0378 23.6101
Hs 445 GDSC1 -3.6193 -1.879 -3.7947 21.8225
SU-DHL-1 GDSC1 -3.6098 -2.5207 -3.6445 20.771
MLMA GDSC1 -3.5913 -1.7889 -3.7911 21.6392
H9 GDSC1 -3.5873 -1.8255 -3.7756 21.5111
ALL-SIL GDSC1 -3.5781 -2.3347 -3.6402 20.5526
OCI-AML-3 GDSC1 -3.5484 -2.9827 -3.5495 19.789
ROS-50 GDSC1 -3.5483 0.1684 -4.5282 26.3103
BE-13 GDSC1 -3.5427 -2.4485 -3.583 19.9681
EHEB GDSC1 -3.4937 -1.8646 -3.662 20.2087
BALL-1 GDSC1 -3.4846 -2.3099 -3.5437 19.3649
KMS-12-BM GDSC1 -3.4775 -2.9128 -3.479 18.9059
OPM-2 GDSC1 -3.4321 -2.0847 -3.5352 18.9999
CESS GDSC1 -3.4319 0.6625 -4.6383 26.3776
L-1236 GDSC1 -3.4217 -1.505 -3.7007 20.0752
PF-382 GDSC1 -3.4126 -1.9017 -3.5626 19.0733
HAL-01 GDSC1 -3.3931 -1.0813 -3.8302 20.8299
OCI-AML-5 GDSC1 -3.3775 -2.1978 -3.4498 18.1134
Mono-Mac-6 GDSC1 -3.3753 -1.9385 -3.5116 18.5149
ML-2 GDSC1 -3.3278 -2.1578 -3.4045 17.522
NOMO-1 GDSC1 -3.2648 -2.265 -3.3143 16.5556
GDM-1 GDSC1 -3.2167 -0.3343 -3.9663 20.8869
Karpas-45 GDSC1 -3.1975 -1.3583 -3.5138 17.5563
RPMI-8226 GDSC1 -3.1757 -0.74 -3.7451 19.1047
DG-75 GDSC1 -3.1374 -1.287 -3.4775 16.9805
RPMI-6666 GDSC1 -3.1072 0.072 -4.0426 20.8852
L-428 GDSC1 -3.0975 -1.4825 -3.3598 15.9304
U266B1 GDSC1 -2.9841 -1.507 -3.2291 14.3987
ST486 GDSC1 -2.9674 1.2159 -4.4528 22.9752
EM-2 GDSC1 -2.8787 -1.491 -3.1226 13.0818
MN-60 GDSC1 -2.8696 -0.7071 -3.4473 15.4215
Granta-519 GDSC1 -2.79 -1.0754 -3.202 13.2131
EoL-1 GDSC1 -2.7012 -1.8228 -2.8115 9.9291
K-562 GDSC1 -2.687 -1.6512 -2.8566 10.1701
HDLM-2 GDSC1 -2.6244 1.9652 -4.504 21.7723
KM-H2 GDSC1 -2.5741 5.0913 -6.0132 29.2453
OCI-M1 GDSC1 -2.5495 -1.6763 -2.6999 8.325
GR-ST GDSC1 -2.4778 -0.6794 -3.0732 10.7831
HL-60 GDSC1 -2.4702 -0.8536 -2.983 10.0572
LAMA-84 GDSC1 -2.443 -0.975 -2.8991 9.2936
KMOE-2 GDSC1 -2.2853 -0.1602 -3.1469 10.5366
WSU-DLCL2 GDSC1 -2.0128 -0.4902 -2.7431 6.3024
ME1 GDSC1 -1.9046 -0.4374 -2.6796 5.4119
MEG-01 GDSC1 -1.8471 2.2354 -3.9683 15.0766
KG-1 GDSC1 -1.7645 0.3379 -2.9545 7.0959
THP-1 GDSC1 -1.7098 1.213 -3.3472 9.9691
JVM-2 GDSC1 -1.529 1.2074 -3.2047 8.2807
P31/FUJ GDSC1 -1.4461 0.762 -2.9246 5.8719
SK-MM-2 GDSC1 -1.4059 3.3799 -4.1876 15.0672
JVM-3 GDSC1 -1.0008 1.1405 -2.8073 3.8472
BC-1 GDSC1 -0.7471 4.9353 -4.4609 14.7774
TUR GDSC1 -0.4004 3.8342 -3.6879 8.6813
EB2 GDSC1 -0.2856 2.985 -3.2207 5.1862
Kasumi-1 GDSC1 -0.1347 5.2625 -4.1914 11.3677
U-698-M GDSC1 -0.0556 5.5887 -4.2942 11.8176
SKM-1 GDSC1 -0.0226 3.7145 -3.3964 5.8251
YT GDSC1 0.4041 5.0214 -3.7377 7.1792
WSU-NHL GDSC1 0.4511 6.0673 -4.1912 9.948
IM-9 GDSC1 0.4776 4.0282 -3.2548 3.9926
Reh GDSC1 0.5036 5.4707 -3.8833 7.9
P30/OHK GDSC1 0.5141 6.9003 -4.5417 11.92
CA46 GDSC1 0.6182 9.1819 -5.5608 17.1272
RL GDSC1 0.6557 2.1212 -2.4346 0.1621
SUP-T1 GDSC1 0.7727 2.7579 -2.6136 0.5324
⏷ Show the Full List of 142 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCE-4 GDSC1 -4.3879 -3.702 -4.3881 30.2778
TE-12 GDSC1 -4.3337 -2.726 -4.3891 29.948
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 -3.5206 -1.4863 -3.8141 21.403
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IMR-5 GDSC1 -4.1897 -2.8256 -4.2233 28.0115
TGW GDSC1 -3.7757 -2.9081 -3.7837 22.6747
NB(TU)1 GDSC1 -3.6881 -1.6422 -3.9427 23.215
NB1 GDSC1 -3.6868 -2.0563 -3.8201 22.3816
GOTO GDSC1 -3.6601 -0.5639 -4.3232 25.6068
LA-N-6 GDSC1 -3.4511 -1.3953 -3.7718 20.7304
GI-ME-N GDSC1 -3.3866 0.0611 -4.3164 24.126
KP-N-YS GDSC1 -3.332 -2.0988 -3.4227 17.6674
Kelly GDSC1 -3.2491 -2.2594 -3.2985 16.3586
NB69 GDSC1 -3.1592 -2.2457 -3.2038 15.2039
SK-N-DZ GDSC1 -2.961 -1.1989 -3.3269 14.9838
SK-N-BE(2)-M17 GDSC1 -2.926 -0.8032 -3.4612 15.7972
KP-N-RT-BM-1 GDSC1 -2.9231 -1.5192 -3.1592 13.5771
CHP-126 GDSC1 -2.8772 -1.0225 -3.3148 14.4758
SJNB-13 GDSC1 -2.7368 -0.6645 -3.3337 13.9435
MHH-NB-11 GDSC1 -2.5459 1.1715 -4.0408 18.3326
SiMa GDSC1 -2.1006 3.3869 -4.7553 21.1825
KP-N-YN GDSC1 -2.0987 6.4536 -6.2868 28.5084
SK-N-FI GDSC1 -1.8997 0.3428 -3.0655 8.4321
SJNB-17 GDSC1 -1.8597 1.4388 -3.5805 12.2715
SJNB-6 GDSC1 -1.5096 0.7347 -2.9573 6.3115
SJNB-5 GDSC1 -1.3775 0.5098 -2.7543 4.3826
SJNB-10 GDSC1 -0.8325 1.8948 -3.0531 5.2251
SJNB-14 GDSC1 -0.783 3.156 -3.6206 9.2053
SJNB-7 GDSC1 -0.4091 3.1313 -3.3633 6.4421
NH-12 GDSC1 0.1243 2.4848 -2.7846 1.7928
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ES6 GDSC1 -7.7647 -1.053 -8.5652 62.6807
NOS-1 [Human HNSCC] GDSC1 -5.7588 -4.0522 -5.7705 47.4428
ES4 GDSC1 -5.0047 -4.099 -5.0052 37.9894
EW-16 GDSC1 -4.9976 -1.7498 -5.3359 39.5026
SJSA-1 GDSC1 -4.6142 -3.4856 -4.6201 33.1418
EW-1 GDSC1 -4.2812 -2.1974 -4.4334 29.9024
SK-ES-1 GDSC1 -4.0156 -2.5356 -4.077 26.0141
ES8 GDSC1 -3.6216 -2.3489 -3.6845 21.1011
SK-PN-DW GDSC1 -3.5522 -2.1945 -3.6404 20.4008
ES1 GDSC1 -2.6975 -1.6561 -2.8661 10.2932
EW-3 GDSC1 -2.4305 -0.8038 -2.9683 9.7674
TC-71 GDSC1 -2.2774 -1.3424 -2.5641 5.9836
H-EMC-SS GDSC1 -2.0902 -0.4869 -2.8114 7.1335
EW-24 GDSC1 -1.9942 -0.2184 -2.8633 7.1815
EW-18 GDSC1 -1.6829 2.2277 -3.8317 13.5123
ES7 GDSC1 -1.5886 4.5362 -4.9081 20.1903
EW-13 GDSC1 -0.4466 3.3479 -3.4884 7.4051
ES5 GDSC1 0.3596 3 -2.8825 2.0236
EW-12 GDSC1 0.8039 2.994 -2.6872 0.7507
EW-11 GDSC1 0.8884 7.197 -4.4434 10.4903
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC1599 GDSC1 -4.4969 -3.0135 -4.528 31.8331
OCUB-M GDSC1 -4.1478 -3.0697 -4.1591 27.3463
CAL-148 GDSC1 -3.4885 -0.8052 -4.0431 22.8145
HCC2157 GDSC1 -3.2154 -1.4995 -3.4802 17.4131
DU4475 GDSC1 -3.0746 -0.9707 -3.5414 17.1211
Evsa-T GDSC1 -3.0515 -1.4362 -3.3281 15.461
HCC1187 GDSC1 -2.7877 -1.8849 -2.8861 10.9255
HCC2218 GDSC1 -2.7448 4.0982 -5.6691 28.5022
MRK-nu-1 GDSC1 -2.6982 1.7775 -4.4781 21.9274
COLO 824 GDSC1 -1.8669 0.9802 -3.3572 10.5896
MFM-223 GDSC1 -0.8564 1.0898 -2.698 2.7825
BT-474 GDSC1 0.358 2.4058 -2.6495 0.9248
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Onda 10 GDSC1 -6.4772 -2.8488 -6.6793 55.3381
KS-1 [Human Krukenberg tumour] GDSC1 -5.8098 -4.1165 -5.8202 48.0718
Onda 11 GDSC1 -5.2966 -3.7366 -5.3095 41.7044
SNB-75 GDSC1 -5.1816 -1.8661 -5.503 41.5372
NMC-G1 GDSC1 -5.0941 -0.2022 -5.9829 42.2521
GB-1 GDSC1 -4.9926 -3.6938 -4.9996 37.8774
SF268 GDSC1 -4.8715 -3.7979 -4.8741 36.3376
KALS-1 GDSC1 -4.4162 -2.9201 -4.4525 30.8574
GI-1 GDSC1 -4.1711 -3.3664 -4.1728 27.5772
Becker GDSC1 -4.1431 -1.8133 -4.3853 28.7615
8-MG-BA GDSC1 -4.0873 -3.1371 -4.0936 26.5587
ONS-76 GDSC1 -4.0504 -2.7503 -4.0843 26.272
D-336MG GDSC1 -3.7411 -2.089 -3.871 23.0358
SF539 GDSC1 -3.6826 -2.7279 -3.699 21.5638
SF126 GDSC1 -3.3029 -1.3808 -3.6181 18.855
KINGS-1 GDSC1 -3.2404 0.0595 -4.1692 22.409
KNS-42 GDSC1 -2.9101 -0.9721 -3.3706 15.0502
D-263MG GDSC1 -2.5286 -1.6116 -2.7032 8.2398
KNS-81-FD GDSC1 -1.9284 1.0304 -3.4328 11.3923
D-502MG GDSC1 -1.0153 1.6422 -3.0524 5.6675
D-247MG GDSC1 -0.9877 2.5838 -3.486 8.7955
U-87MG ATCC GDSC1 -0.8496 1.9921 -3.1098 5.6765
AM-38 GDSC1 0.106 4.4264 -3.6447 7.2058
CAS-1 GDSC1 0.7395 8.8424 -5.3155 15.6159
D283 Med GDSC1 1.4661 9.7361 -5.2637 13.6863
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC1TKB GDSC1 -5.3224 -3.3042 -5.3688 42.1787
ETK-1 GDSC1 -5.2697 -4.148 -5.2713 41.3083
TGBC24TKB GDSC1 -2.1916 -0.8118 -2.7403 6.9785
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RL95-2 GDSC1 -4.5236 -4.0817 -4.5236 31.9733
KLE GDSC1 -4.458 0.7371 -5.7085 37.244
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RXF 393L GDSC1 -5.5225 -3.1166 -5.6044 44.7462
LB1047-RCC GDSC1 -5.0486 -3.1412 -5.097 38.8045
OS-RC-2 GDSC1 -4.5538 -2.7931 -4.6148 32.7266
BB65-RCC GDSC1 -4.4964 -2.7718 -4.5565 32.0068
LB996-RCC GDSC1 -4.416 -2.4197 -4.5309 31.3431
TK-10 GDSC1 -4.114 -2.1942 -4.252 27.7355
RCC10RGB GDSC1 -3.6198 4.5823 -6.7031 35.9876
HA7-RCC GDSC1 -3.5587 -2.4 -3.6078 20.2256
A-498 GDSC1 -2.8047 9.2982 -8.3113 36.5747
A-704 GDSC1 -2.6403 -0.9984 -3.084 11.6101
LB2241-RCC GDSC1 0.997 3.2352 -2.6993 0.6762
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LS411N GDSC1 -4.714 -2.8546 -4.7773 34.7345
COLO 320HSR GDSC1 -4.3166 -3.3784 -4.32 29.4066
NCI-H747 GDSC1 -4.218 -1.8382 -4.4597 29.6803
LS123 GDSC1 -4.0449 -2.5639 -4.1039 26.3647
RKO GDSC1 -3.8756 -2.8227 -3.8931 23.9831
SNU-C2B GDSC1 -3.1513 -1.4448 -3.4315 16.7259
KM12 GDSC1 -3.1461 -1.1712 -3.533 17.4249
LS1034 GDSC1 -2.8492 -1.436 -3.1127 12.8569
LS513 GDSC1 -2.4628 -1.0734 -2.8724 9.1802
MDST8 GDSC1 -2.1394 -1.3116 -2.4468 4.4734
C2BBe1 GDSC1 -1.6805 1.8246 -3.6288 12.0076
NCI-H716 GDSC1 -0.2095 3.4752 -3.3992 6.2424
CW-2 GDSC1 -0.013 1.992 -2.6504 1.2684
CL-11 GDSC1 0.296 2.7755 -2.8215 1.7815
SNU-C1 GDSC1 0.7412 9.3259 -5.546 16.7526
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 -0.8407 1.7045 -2.9696 4.6437
Cancer Drug Sensitivity Data Curated from 63 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1355 GDSC1 -5.7239 3.2421 -8.114 48.6268
LC-2/ad GDSC1 -5.5795 -3.5613 -5.6147 45.297
HOP-62 GDSC1 -4.8371 -3.6754 -4.8417 35.9195
IA-LM GDSC1 -4.5015 -3.7428 -4.5019 31.699
LXF 289 GDSC1 -4.4677 -3.6703 -4.4684 31.2784
NCI-H847 GDSC1 -4.0678 -2.8097 -4.0962 26.4545
NCI-H1975 GDSC1 -4.0617 -2.7918 -4.0916 26.3879
NCI-H748 GDSC1 -3.7966 -1.8159 -4.0067 24.2629
NCI-H1963 GDSC1 -3.7947 -1.5072 -4.1034 24.899
NCI-H1648 GDSC1 -3.7911 -2.1444 -3.912 23.5996
NCI-H1876 GDSC1 -3.7657 -1.7709 -3.9866 23.9511
NCI-H510A GDSC1 -3.7519 -2.1338 -3.8718 23.1043
NCI-H1092 GDSC1 -3.4729 -0.1383 -4.3143 24.5565
NCI-H2141 GDSC1 -3.3801 -1.2278 -3.7588 20.2587
Ms-1 GDSC1 -3.372 -2.1356 -3.4576 18.1327
NCI-H2135 GDSC1 -3.3496 -1.3148 -3.6929 19.6322
NCI-H1869 GDSC1 -3.3401 -0.9944 -3.8094 20.4046
NCI-H1304 GDSC1 -3.3346 -1.3848 -3.6505 19.2532
SHP-77 GDSC1 -3.1762 -1.6733 -3.3768 16.4748
NCI-H1650 GDSC1 -3.089 -1.3346 -3.4073 16.225
NCI-H64 GDSC1 -3.0313 -0.458 -3.723 18.2323
NCI-H345 GDSC1 -2.9934 -1.5243 -3.2326 14.4735
IST-SL2 GDSC1 -2.9765 1.4295 -4.565 23.7221
COR-L95 GDSC1 -2.917 -0.8351 -3.4379 15.5812
NCI-H209 GDSC1 -2.9021 -0.3166 -3.659 17.1462
Lu-139 GDSC1 -2.8944 -1.0096 -3.3381 14.7324
IST-SL1 GDSC1 -2.8727 -0.1677 -3.6995 17.3074
NCI-H23 GDSC1 -2.852 -1.155 -3.2317 13.7387
NCI-H524 GDSC1 -2.8174 3.4619 -5.4183 27.6641
Lu-65 GDSC1 -2.7114 0.0017 -3.6237 16.009
NCI-H82 GDSC1 -2.6895 -1.8689 -2.784 9.6741
Lu-134-A GDSC1 -2.6815 -0.3192 -3.4416 14.5043
NCI-H1581 GDSC1 -2.6457 -1.5105 -2.8676 10.0337
NCI-H526 GDSC1 -2.608 -1.4978 -2.8331 9.5901
NCI-H211 GDSC1 -2.5909 -0.9655 -3.0496 11.1179
NCI-H2196 GDSC1 -2.5735 0.1618 -3.5705 15.0027
Calu-6 GDSC1 -2.5723 -1.854 -2.6613 8.175
HCC33 GDSC1 -2.4348 -0.3638 -3.1848 11.4549
NCI-H446 GDSC1 -2.4279 5.2594 -5.9703 28.4985
NCI-H1694 GDSC1 -2.4065 -0.9945 -2.8543 8.786
NCI-H187 GDSC1 -2.3508 6.0652 -6.3065 29.5083
NCI-H1155 GDSC1 -2.3142 -1.0723 -2.7281 7.4055
NCI-H226 GDSC1 -2.2848 0.269 -3.359 12.1809
COR-L88 GDSC1 -2.2334 1.4701 -3.9115 16.1296
COLO 668 GDSC1 -2.2321 -0.8004 -2.7829 7.4784
NCI-H69 GDSC1 -2.1605 -0.5013 -2.866 7.8378
LB647-SCLC GDSC1 -2.145 -1.2018 -2.5058 4.9557
NCI-H1436 GDSC1 -2.0383 -0.1608 -2.9294 7.8655
NCI-H1836 GDSC1 -2.0128 -0.1342 -2.9211 7.7051
NCI-H2171 GDSC1 -2.0082 0.4434 -3.2059 9.9236
CPC-N GDSC1 -1.9973 -0.2219 -2.8642 7.1999
NCI-H128 GDSC1 -1.9707 0.5687 -3.2372 10.0307
SBC-1 GDSC1 -1.8741 -0.5524 -2.5976 4.6608
NCI-H1770 GDSC1 -1.8379 1.1636 -3.4252 11.0109
NCI-H1838 GDSC1 -1.606 0.965 -3.1432 8.0507
NCI-H2081 GDSC1 -1.6027 0.6514 -2.9855 6.8153
DMS 79 GDSC1 -1.4657 5.6465 -5.3636 22.2137
DMS 114 GDSC1 -1.2368 1.064 -2.9246 5.2907
NCI-H720 GDSC1 -0.4751 1.9092 -2.8473 3.0589
NCI-H322M GDSC1 -0.124 6.3102 -4.6875 14.393
Lu-165 GDSC1 0.0243 1.8639 -2.5841 0.9291
EKVX GDSC1 0.6352 4.6256 -3.4295 4.7951
NCI-H1666 GDSC1 0.8346 3.1094 -2.7175 0.8375
⏷ Show the Full List of 63 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 -3.8374 -0.9388 -4.3582 26.8113
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-8 GDSC1 -5.1737 -3.9727 -5.1768 40.1169
TE-11 GDSC1 -4.9316 -3.5865 -4.9411 37.1302
TE-15 GDSC1 -4.9079 -2.6238 -5.0239 37.4216
TE-10 GDSC1 -4.6263 -2.7523 -4.6985 33.6971
TE-5 GDSC1 -3.6121 -1.2398 -4.0023 23.1991
TE-9 GDSC1 -3.4713 -2.9288 -3.4724 18.8259
TE-1 GDSC1 -2.5761 4.1619 -5.552 27.2762
EC-GI-10 GDSC1 -2.4442 -0.7837 -2.9911 10.0035
TE-6 GDSC1 -2.146 -0.4457 -2.8808 7.8963
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Kuramochi GDSC1 -4.6252 -2.9735 -4.6677 33.505
OVCAR-4 GDSC1 -3.4602 -1.9708 -3.5953 19.5663
ES-2 GDSC1 -2.7257 -1.2071 -3.0785 11.982
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PSN1 GDSC1 -6.0208 -4.4653 -6.0254 50.6828
MZ-PC-1 GDSC1 -4.5314 -2.7306 -4.6001 32.4951
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IST-Mes1 GDSC1 -3.6122 -1.3615 -3.9575 22.8932
MPP 89 GDSC1 -3.3072 0.1294 -4.268 23.4058
MSTO-211H GDSC1 -0.5525 3.0944 -3.4373 7.3028
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VCaP GDSC1 -3.3977 -2.4942 -3.4222 18.0539
LNCaP clone FGC GDSC1 0.3623 6.6396 -4.5173 12.1403
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 -4.0711 -2.9844 -4.0849 26.4031
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HT-144 GDSC1 -5.8062 -2.8363 -5.9554 48.2017
A101D GDSC1 -5.414 -4.0732 -5.4183 43.1251
A-388 GDSC1 -4.5636 -3.5685 -4.5665 32.4904
CP67-MEL GDSC1 -4.3471 1.0552 -5.736 36.6792
IST-MEL1 GDSC1 -4.244 -3.1293 -4.2552 28.5479
MZ-MEL-2 GDSC1 -4.1923 -2.6727 -4.2455 28.1687
LB373-MEL-D GDSC1 -3.7692 -1.8996 -3.9524 23.7419
MMAc-SF GDSC1 -3.6227 -2.3042 -3.6941 21.1705
DJM-1 GDSC1 -3.4314 -2.5126 -3.4558 18.4745
LB2518-MEL GDSC1 -3.4207 -2.9746 -3.421 18.1883
LOX-IMVI GDSC1 -3.4043 -1.6997 -3.6157 19.3906
SH-4 GDSC1 -2.8841 -1.7813 -3.0238 12.4128
GAK GDSC1 -2.6556 -1.8939 -2.7394 9.1779
UACC-257 GDSC1 -2.4991 -1.7293 -2.626 7.5313
CP66-MEL GDSC1 -2.3875 -1.6728 -2.5294 6.2544
COLO 829 GDSC1 -2.3432 10.8328 -8.6823 35.819
SK-MEL-2 GDSC1 -0.5985 8.4661 -6.0907 22.8369
COLO 800 GDSC1 -0.4447 3.8195 -3.7101 8.9466
MZ-MEL-7 GDSC1 -0.3826 3.2009 -3.3792 6.4915
SK-MEL-1 GDSC1 0.9992 8.6 -5.0292 13.5164
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 -4.4471 -3.7344 -4.4474 31.0181
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW982 GDSC1 -5.4129 -4.3823 -5.4135 43.0925
SW872 GDSC1 -5.2335 -3.4514 -5.2619 40.9962
VA-ES-BJ GDSC1 -4.8147 -3.5809 -4.8217 35.6542
MFH-ino GDSC1 -4.7067 -1.0918 -5.2342 36.9968
TE 441.T GDSC1 -4.6164 -3.5105 -4.6216 33.1653
SK-LMS-1 GDSC1 -3.8017 -3.018 -3.8058 22.9747
SK-UT-1 GDSC1 -3.6218 4.8958 -6.8585 36.4166
EW-8 GDSC1 -2.4421 0.1608 -3.4481 13.5124
SW684 GDSC1 0.4258 1.791 -2.403 0.1637
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RF-48 GDSC1 -4.9627 -3.2591 -4.9946 37.6475
HSC-39 GDSC1 -3.4736 -2.5344 -3.498 19.0025
GCIY GDSC1 -3.452 -2.4544 -3.4852 18.7889
SNU-16 GDSC1 -3.4269 -1.2042 -3.8179 20.9225
SNU-1 GDSC1 -3.3924 0.5021 -4.5247 25.4845
SCH GDSC1 -3.0607 -1.0978 -3.4733 16.5556
SNU-5 GDSC1 -2.6503 -1.4566 -2.8944 10.2524
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
K5 GDSC1 -5.1164 -3.6662 -5.1275 39.4471
CGTH-W-1 GDSC1 -4.0467 -1.8444 -4.271 27.4572
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BB30-HNC GDSC1 -4.741 -3.8929 -4.7415 34.6933
LB771-HNC GDSC1 -3.8977 -2.1994 -4.0153 24.9082
BB49-HNC GDSC1 -3.198 1.1076 -4.6203 25.1083
SCC-15 GDSC1 -0.748 5.8344 -4.9033 17.4254
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KGN GDSC1 -6.201 -5.0256 -6.2013 52.9362
LB831-BLC GDSC1 -4.8959 -3.716 -4.9005 36.6545
SW962 GDSC1 -4.8261 -3.5406 -4.8348 35.8074
NT2-D1 GDSC1 -4.6739 -3.9895 -4.674 33.8526
SW954 GDSC1 -4.6473 -3.7912 -4.6481 33.5245
NCC-IT GDSC1 -4.5375 -2.6576 -4.6183 32.6442
NEC8 GDSC1 -4.0437 -2.8766 -4.0645 26.1054
JAR GDSC1 -3.6562 -2.1099 -3.7733 21.8909
OMC-1 [Human cervical carcinoma] GDSC1 -3.6043 -1.9499 -3.7583 21.4912
DSH1 GDSC1 -2.6919 -1.8167 -2.8035 9.8227
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010054)
2 Synthesis and discovery of pyrazine-pyridine biheteroaryl as a novel series of potent vascular endothelial growth factor receptor-2 inhibitors. J Med Chem. 2005 Mar 24;48(6):1886-900.