Details of the Drug

General Information of Drug (ID: DM4ZBK6)

Drug Name
Fedratinib
Synonyms TG101348
Indication
Disease Entry ICD 11 Status REF
Myelofibrosis 2A20.2 Approved [1]
Polycythemia vera 2A20.4 Approved [2]
Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [3]
ATC Code
L01EJ02: Fedratinib
L01EJ: Janus-associated kinase (JAK) inhibitors
L01E: PROTEIN KINASE INHIBITORS
L01: ANTINEOPLASTIC AGENTS
L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 2 Molecular Weight (mw) 524.7
Logarithm of the Partition Coefficient (xlogp) 4.8
Rotatable Bond Count (rotbonds) 11
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 9
ADMET Property
Absorption AUC
The area under the plot of plasma concentration (AUC) of drug is 26.870 mgh/L [4]
Absorption Cmax
The maximum plasma concentration (Cmax) of drug is 1804 mcg/L [4]
Absorption Tmax
The time to maximum plasma concentration (Tmax) is 1.75-3 h [4]
Clearance
The clearance of drug is 13 L/h [4]
Elimination
An oral dose of fedratinib is 77% eliminated in the feces with 23% as unchanged drug, and 5% is eliminated in the urine with 3% as unchanged drug [4]
Half-life
The concentration or amount of drug in body reduced by one-half in 41 hours [4]
Metabolism
The drug is metabolized via the CYP3A4, CYP2C19, and flavin-containing monooxygenase 3 [4]
Vd
The volume of distribution (Vd) of drug is 1770 L [4]
Chemical Identifiers
Formula
C27H36N6O3S
IUPAC Name
N-tert-butyl-3-[[5-methyl-2-[4-(2-pyrrolidin-1-ylethoxy)anilino]pyrimidin-4-yl]amino]benzenesulfonamide
Canonical SMILES
CC1=CN=C(N=C1NC2=CC(=CC=C2)S(=O)(=O)NC(C)(C)C)NC3=CC=C(C=C3)OCCN4CCCC4
InChI
InChI=1S/C27H36N6O3S/c1-20-19-28-26(30-21-10-12-23(13-11-21)36-17-16-33-14-5-6-15-33)31-25(20)29-22-8-7-9-24(18-22)37(34,35)32-27(2,3)4/h7-13,18-19,32H,5-6,14-17H2,1-4H3,(H2,28,29,30,31)
InChIKey
JOOXLOJCABQBSG-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
16722836
ChEBI ID
CHEBI:91408
CAS Number
936091-26-8
UNII
6L1XP550I6
DrugBank ID
DB12500
TTD ID
D0G8BM
ACDINA ID
D01069
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Janus kinase 2 (JAK-2) TTRMX3V JAK2_HUMAN Inhibitor [1]
HUMAN janus kinase 2 (JAK-2) TT0F5HE JAK2_HUMAN Inhibitor [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [5]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Gene/Protein Processing [5]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Gene/Protein Processing [5]
Suppressor of cytokine signaling 3 (SOCS3) OTY183WJ SOCS3_HUMAN Gene/Protein Processing [6]
Vascular endothelial growth factor A, long form OTIM9MZ3 VEGFA_HUMAN Gene/Protein Processing [5]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Myelofibrosis
ICD Disease Classification 2A20.2
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Janus kinase 2 (JAK-2) DTT JAK2 2.46E-01 -0.41 -0.6
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 42 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 1.0783 3.4881 0.8331 30.0171
NOS-1 [Human HNSCC] GDSC1 -1.3051 2.5194 -1.5292 56.7294
EW-1 GDSC1 -0.6943 2.3495 -0.8357 50.5638
ES5 GDSC1 -0.6831 2.0216 -0.7723 50.4541
ES1 GDSC1 -0.1379 1.4804 -0.1507 43.7356
ES7 GDSC1 0.0633 2.8118 -0.1048 41.888
HuO9 GDSC1 0.1451 2.681 0.0104 40.7785
ES4 GDSC1 0.2227 4.1625 -0.3133 41.3297
EW-11 GDSC1 0.2425 3.4763 -0.0754 40.3613
Hs 888.T CTRP2 0.3459 2.8061 0.3172 32.4376
EW-18 GDSC1 0.4848 3.2241 0.2576 37.1241
SK-ES-1 GDSC1; CTRP2 0.49 2.5686 0.4772 31.4265
MHH-ES-1 GDSC1; CTRP2 0.5809 3.5737 0.4927 31.0733
ES8 GDSC1 0.6401 3.7801 0.2663 36.0016
G-292 clone A141B1 GDSC1; CTRP2 1.1995 3.5962 1.1456 26.8468
EW-3 GDSC1 1.2545 5.2853 0.3514 31.7003
Hs 822.T CTRP2 1.3068 3.5609 1.2621 26.1027
SaOS-2 GDSC1; CTRP2 1.311 2.2522 1.3109 25.9245
SW1353 CTRP2 1.4665 4.286 1.3346 25.3389
SK-N-MC CTRP2 1.4983 2.0652 1.4983 24.6787
TC-71 GDSC1 1.568 3.2551 1.4314 23.2407
SJSA-1 GDSC1; CTRP2 1.6756 4.5055 1.3493 20.6232
CAL-78 GDSC1; CTRP2 1.7433 4.0183 1.6729 23.2877
EW-7 GDSC1 1.8752 4.6631 1.2611 22.7168
HuO-3N1 GDSC1 1.9158 4.8475 1.2239 22.7615
TC71 CTRP2 2.098 4.699 1.9383 21.2395
U2OS GDSC1; CTRP2; CTRP1 2.115 4.1221 2.0553 20.7795
EW-13 GDSC1 2.234 4.639 1.642 18.1953
SK-PN-DW GDSC1 2.2657 4.3431 1.8031 16.8644
EW-16 GDSC1 2.2866 5.4996 1.3007 20.3918
ES6 GDSC1 2.4542 4.8506 1.7688 16.1996
A-673 GDSC1; CTRP2 2.7458 3.8503 2.7384 16.408
CHSA0108 GDSC1 2.7679 4.0294 2.4573 9.5535
CHSA0011 GDSC1 2.809 5.2648 1.9148 13.4997
CADO-ES1 GDSC1 2.8388 4.0876 2.5032 8.8699
CHSA8926 GDSC1 2.8838 3.5677 2.7706 6.6755
EW-24 GDSC1 2.8968 3.3021 2.8685 5.9254
H-EMC-SS GDSC1 2.9235 5.4197 1.9448 12.7852
MG-63 GDSC1; CTRP2 3.3931 4.053 3.3917 12.0831
HOS GDSC1; CTRP2 4.0854 4.9132 4.0491 7.5986
CAL-72 GDSC1 5.373 6.8989 2.856 0.4632
NY GDSC1 5.9185 9.2606 2.1669 3.2173
⏷ Show the Full List of 42 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 206 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JK1 CTRP2 -0.2793 2.4081 -0.3065 36.5876
MEC1 CTRP2 1.551 3.1708 1.5407 24.3629
JM1 GDSC1; CTRP2 0.8357 2.8057 0.8222 29.1302
OCI-M1 GDSC1; CTRP2 -3.7093 -1.7468 -3.7093 59.3028
MV4-11 GDSC1; CTRP2 -3.4141 -0.786 -3.4159 57.3149
MOLM-13 GDSC1; CTRP2 -3.0213 -0.6855 -3.0223 54.7257
ALL-PO GDSC1 -2.9036 -0.8119 -2.9062 76.4894
697 GDSC1; CTRP2 -2.0798 0.9455 -2.0936 48.4864
MOLT-16 GDSC1; CTRP2 -1.7466 -0.4273 -1.7466 46.2571
NKM-1 GDSC1 -1.7318 1.9495 -1.8853 61.188
A3/Kawakami GDSC1; CTRP2 -1.673 0.34 -1.674 45.7704
DND-41 GDSC1; CTRP2 -1.5401 1.8385 -1.5778 44.9635
Mono-Mac-1 CTRP2 -1.4498 2.0816 -1.5001 44.3941
SIG-M5 GDSC1; CTRP2 -1.3322 0.5077 -1.3329 43.5036
Mono-Mac-6 GDSC1; CTRP2 -1.2872 4.3398 -1.6633 43.9029
KG-1 GDSC1 -1.1635 0.8105 -1.1752 56.3379
MOLM-16 CTRP2; CTRP1 -1.102 0.6902 -1.1027 41.9729
NALM-6 GDSC1; CTRP2 -1.0509 1.6414 -1.0657 41.6741
JSC-1 GDSC1 -0.8945 3.8888 -1.4384 52.2715
EoL-1 GDSC1; CTRP2 -0.8666 1.1614 -0.8692 40.4138
M-07e CTRP2 -0.8316 1.739 -0.845 40.2138
EB2 GDSC1 -0.7676 4.1156 -1.3724 51.1078
ALL-SIL GDSC1; CTRP2 -0.7211 1.6038 -0.7289 39.4626
GDM-1 GDSC1; CTRP2; CTRP1 -0.714 1.5641 -0.7208 39.412
Sc-1 GDSC1 -0.7081 2.8271 -0.9468 50.6796
LC4-1 GDSC1 -0.7064 3.837 -1.2175 50.5843
KMS-26 CTRP2 -0.6939 1.9115 -0.7101 39.3075
F-36P CTRP2 -0.6876 0.8844 -0.6879 39.216
RPMI-8402 GDSC1; CTRP2 -0.6818 0.7267 -0.6819 39.177
SR GDSC1; CTRP2 -0.6524 2.4086 -0.6932 39.1049
P30/OHK GDSC1 -0.63 1.6693 -0.6754 49.8338
ATN-1 GDSC1 -0.6153 3.3898 -0.9873 49.715
BV-173 GDSC1; CTRP2 -0.5971 1.9421 -0.6122 38.661
OCI-AML-5 GDSC1; CTRP2 -0.5955 1.8204 -0.6067 38.6383
Karpas-231 GDSC1 -0.5836 1.7027 -0.6298 49.2784
SU-DHL-16 GDSC1 -0.5142 0.6764 -0.5151 48.3818
KOPN-8 GDSC1 -0.4183 1.1234 -0.4247 47.1996
CESS GDSC1 -0.398 2.5376 -0.5499 47.2213
NCI-H929 CTRP2 -0.3623 2.5691 -0.4026 37.1793
MOLT-13 GDSC1; CTRP2 -0.3283 1.7881 -0.3344 36.8459
SUP-HD1 GDSC1; CTRP2 -0.322 2.1464 -0.3382 36.8362
SU-DHL-5 GDSC1; CTRP1 -0.28 2.1272 -0.2945 55.5802
SET-2 CTRP2 -0.2149 1.5903 -0.2172 36.0792
HH [Human lymphoma] GDSC1; CTRP2 -0.1747 6.8418 -1.1811 38.4043
KMS-11 GDSC1; CTRP2; CTRP1 -0.1652 2.3511 -0.1859 35.8086
NOMO-1 GDSC1; CTRP2; CTRP1 -0.1366 2.9067 -0.1938 35.7347
Ri-1 CTRP2 -0.1329 3.8289 -0.3103 36.0753
MHH-CALL-4 CTRP2 -0.1074 4.6264 -0.4448 36.3661
AML-193 CTRP2 -0.1043 1.628 -0.1062 35.3425
KE-37 GDSC1; CTRP2 -0.0816 2.0544 -0.09 35.2127
KMS-12-BM GDSC1; CTRP2 -0.0755 1.6041 -0.0771 35.1499
QIMR-WIL GDSC1 -0.0702 4.0846 -0.6047 44.3892
Loucy GDSC1 -0.0329 2.0154 -0.0808 42.5835
Karpas-45 GDSC1 -0.0259 2.4636 -0.135 42.7352
BC-1 GDSC1 0.0389 2.7884 -0.1263 42.1657
BL-41 GDSC1 0.0477 3.6672 -0.344 42.7888
LAMA-84 GDSC1; CTRP2 0.06 2.6171 -0.0062 29.5988
MEG-01 GDSC1 0.0736 3.3852 -0.2342 42.2477
HEL GDSC1; CTRP2 0.0759 1.2402 0.0759 34.1379
GR-ST GDSC1 0.0765 4.4392 -0.568 43.1467
KHM-1B CTRP2 0.0813 1.7433 0.0796 34.1076
TUR GDSC1 0.1747 3.1318 -0.0573 40.818
SKM-1 CTRP2; CTRP1 0.1787 1.8671 0.1765 33.4614
SU-DHL-10 GDSC1; CTRP2 0.182 2.1123 0.1763 33.4511
NCO2 CTRP2 0.2039 2.3762 0.1914 33.328
SU-DHL-8 GDSC1; CTRP2 0.2243 4.3363 -0.0199 33.9317
HC-1 GDSC1 0.2293 4.893 -0.5717 42.0163
Peer CTRP2 0.2407 1.826 0.2393 33.0465
SK-MM-2 GDSC1; CTRP2 0.2685 3.196 0.2047 35.5795
BL-70 CTRP2; CTRP1 0.2902 3.0511 0.241 32.8753
RPMI-6666 GDSC1; CTRP2 0.2941 5.507 -0.2389 34.3386
NU-DUL-1 GDSC1; CTRP2; CTRP1 0.3046 2.6115 0.2851 32.6816
CTV-1 GDSC1 0.3121 3.0816 0.1048 39.0931
RS4;11 GDSC1; CTRP2 0.3368 2.6516 0.2828 29.8455
HuT 78 CTRP2 0.3573 3.2112 0.2967 32.467
Ki-JK CTRP2 0.3914 2.5055 0.3786 32.0825
WIL2 NS GDSC1 0.4136 4.8325 -0.3517 40.0616
OCI-AML-2 GDSC1; CTRP2 0.4167 1.5934 0.4166 31.872
MHH-CALL-3 CTRP2 0.4309 4.5604 0.1563 32.6703
OCI-AML-3 GDSC1; CTRP2; CTRP1 0.4468 1.6819 0.4465 31.6723
ML-2 GDSC1 0.4597 2.7756 0.3326 36.9201
KMS-21-BM CTRP2 0.4753 3.3502 0.4069 31.7087
JJN-3 GDSC1; CTRP2 0.4912 2.5786 0.478 31.4199
THP-1 GDSC1; CTRP2; CTRP1 0.5109 2.7175 0.4924 31.3069
KCL-22 GDSC1; CTRP2 0.5119 2.3315 0.5062 31.2574
YT GDSC1 0.5224 6.3941 -0.884 40.8412
Ku812 GDSC1; CTRP2; CTRP1 0.5265 2.3672 0.5203 31.1621
PL-21 GDSC1 0.5267 3.7678 0.1468 37.3495
VL51 GDSC1 0.5452 10.2225 -2.6302 43.7104
Kasumi-2 CTRP2 0.5551 2.6601 0.5404 31.0001
Reh GDSC1; CTRP2 0.5983 3.0156 0.5655 30.7733
MM1.S CTRP2 0.6162 2.915 0.5906 30.6303
PF-382 GDSC1; CTRP2 0.6282 2.7533 0.6114 30.521
U-937 CTRP2; CTRP1 0.6308 3.2316 0.5823 30.6094
HAL-01 GDSC1 0.6534 2.2062 0.6232 33.97
KE-97 CTRP2; CTRP1 0.6548 3.5015 0.5799 30.5381
PL21 CTRP2; CTRP1 0.661 2.6674 0.6485 30.2887
Kasumi-1 GDSC1; CTRP2 0.6884 1.8653 0.6882 30.0653
CTB-1 GDSC1 0.6915 4.7932 -0.0401 37.0239
H9 GDSC1 0.7086 3.2844 0.4861 34.3988
Jurkat CTRP2 0.72 2.2922 0.7086 24.6861
SUP-M2 GDSC1; CTRP2 0.7208 3.5012 0.6499 30.0861
MOLM-6 CTRP2 0.7455 2.5045 0.7394 29.7052
MOLP-8 GDSC1; CTRP2 0.755 2.9448 0.7324 29.6973
P32/ISH GDSC1 0.7705 2.7982 0.6647 32.9683
TF-1 CTRP2 0.7751 1.5178 0.7751 29.4884
KMS-20 CTRP2 0.7883 3.4055 0.7314 29.5908
MY-M12 GDSC1 0.8014 9.9035 -2.2313 41.963
HDLM-2 GDSC1; CTRP2 0.8343 3.2638 0.7928 29.2332
BC-3 GDSC1 0.8873 3.1478 0.7157 31.9187
Karpas-620 GDSC1; CTRP2 0.8942 3.5905 0.8234 28.9339
KYO-1 CTRP2 0.9175 2.6884 0.9097 28.567
SU-DHL-6 GDSC1; CTRP2 0.9547 3.7957 0.8618 28.6062
P31/FUJ GDSC1; CTRP2 0.9753 2.8819 0.9622 28.2007
TALL-1 [Human adult T-ALL] CTRP2 1.0314 2.9264 1.018 27.8285
WSU-DLCL2 GDSC1; CTRP2; CTRP1 1.0389 2.9871 1.023 27.7871
L-540 GDSC1; CTRP2 1.0863 3.1591 1.0628 27.4974
KMS-27 CTRP2 1.0904 3.4997 1.0403 27.5597
A4/Fukuda GDSC1; CTRP2 1.0905 2.6394 1.0864 27.4045
OCI-Ly19 GDSC1; CTRP2 1.0967 4.7012 0.8489 28.1907
Mino CTRP2 1.113 1.7916 1.113 27.2411
OPM-2 GDSC1; CTRP2 1.1147 2.5541 1.1122 27.2379
Hs 445 GDSC1 1.1372 5.4518 0.1585 33.3487
JURL-MK1 GDSC1; CTRP2 1.141 3.3804 1.1041 27.1786
L-363 GDSC1; CTRP2 1.1803 3.9644 1.0791 27.1354
KO52 CTRP2 1.1946 2.0995 1.1945 26.699
SUP-B15 GDSC1; CTRP2 1.2069 3.7431 1.137 26.8523
NB4 GDSC1; CTRP2 1.2371 3.2956 1.2105 26.5049
CML-T1 CTRP2 1.2542 3.4313 1.2183 26.4226
KMS-34 CTRP2 1.2691 2.8393 1.2633 26.2223
L-428 GDSC1; CTRP2 1.2713 3.6912 1.2113 26.3905
P3HR-1 CTRP2; CTRP1 1.2794 4.8677 1.0087 27.06
EM-2 GDSC1; CTRP2 1.2919 2.9884 1.2823 26.0833
HL-60 GDSC1; CTRP2 1.32 3.4148 1.2883 25.971
HuNS1 CTRP2 1.3222 4.7377 1.0861 26.6569
ST486 GDSC1; CTRP2 1.3471 2.7152 1.3446 25.6928
Daudi GDSC1; CTRP2 1.3588 2.1815 1.3588 25.6067
BE-13 GDSC1 1.3589 3.9985 0.9725 27.4726
CCRF-CEM GDSC1 1.3651 3.1664 1.232 25.7473
SUP-T1 GDSC1; CTRP2 1.3745 3.6832 1.3213 25.681
RCH-ACV CTRP2 1.3935 3.0359 1.3845 25.406
NU-DHL-1 CTRP2 1.4 3.3823 1.3739 25.4198
Karpas-299 GDSC1; CTRP2 1.4011 3.1496 1.3879 25.3692
Ramos.2G6.4C10 GDSC1 1.415 2.5444 1.392 24.4099
Karpas-422 GDSC1; CTRP2 1.435 3.9923 1.3475 25.3956
L-1236 GDSC1; CTRP2 1.4365 5.1443 1.1095 26.2155
CMK CTRP2 1.437 2.0217 1.437 25.0864
DB GDSC1; CTRP2 1.4428 3.8038 1.3801 25.2595
KMS-28BM CTRP2 1.4434 3.4204 1.4164 25.1345
KMOE-2 GDSC1 1.4629 4.3461 0.9551 26.9892
ROS-50 GDSC1 1.4905 4.8432 0.784 27.9031
MLMA GDSC1 1.4979 5.3626 0.5694 29.1286
ME1 CTRP2 1.507 4.5772 1.3223 25.2526
MOTN-1 CTRP2 1.5279 4.0973 1.4316 24.8084
CA46 GDSC1; CTRP2 1.5317 4.8427 1.2897 25.2885
GA-10 CTRP2 1.5793 2.3775 1.5793 24.1403
Hs 611.T CTRP2 1.5877 3.6414 1.5497 24.2123
MOLT-3 CTRP2 1.5957 2.0709 1.5957 24.031
Namalwa GDSC1; CTRP2 1.6162 4.569 1.4425 24.4896
HPB-ALL CTRP2 1.6525 2.8595 1.6508 23.6593
HT GDSC1; CTRP2; CTRP1 1.6754 4.4917 1.5222 24.0246
RPMI-8226 GDSC1; CTRP2; CTRP1 1.6758 3.9319 1.6121 23.7138
EB1 CTRP2 1.6839 4.2913 1.5681 23.8384
ARH-77 GDSC1 1.6888 5.6259 0.6469 27.643
HEL 92.1.7 CTRP2 1.699 2.1268 1.699 23.3441
Farage GDSC1 1.7169 5.4299 0.7634 26.795
EHEB CTRP2 1.7198 5.5391 1.3063 24.6475
MOLT-4 GDSC1 1.7292 4.2646 1.2703 23.4309
SUP-T11 CTRP2 1.7472 2.8825 1.7459 23.0281
P12-Ichikawa GDSC1; CTRP2 1.7771 4.0091 1.7101 23.0513
JeKo-1 CTRP2 1.7817 3.8986 1.7283 22.9742
VAL GDSC1 1.7839 4.0438 1.4134 22.1511
DEL GDSC1; CTRP2 1.8049 3.7774 1.7653 22.7733
OCI-Ly10 CTRP2; CTRP1 1.815 4.8828 1.5889 23.3529
SCC-3 GDSC1 1.8394 4.2635 1.3879 22.0292
BALL-1 GDSC1 1.8792 3.7057 1.6369 20.082
K-562 GDSC1; CTRP2 1.9761 4.0592 1.9154 21.7067
U266B1 GDSC1; CTRP2 2.0016 4.5424 1.8656 21.7975
MN-60 GDSC1 2.0587 6.0252 0.8304 24.6323
TK [Human B-cell lymphoma] GDSC1 2.067 6.7198 0.508 26.5222
LP-1 GDSC1; CTRP2; CTRP1 2.0963 4.7464 1.9262 21.2873
MC116 GDSC1; CTRP2; CTRP1 2.1347 3.3265 2.1309 20.4597
SU-DHL-1 GDSC1; CTRP2 2.1693 3.6302 2.1557 20.2622
KMS-18 CTRP2 2.3191 4.4379 2.2273 19.5333
JVM-2 GDSC1; CTRP2 2.3443 6.5988 1.2289 17.5663
KM-H2 GDSC1; CTRP2 2.3687 4.4933 2.1072 13.8645
SU-DHL-4 GDSC1; CTRP2; CTRP1 2.3894 4.7816 2.2372 19.2769
RPMI-8866 GDSC1 2.4154 5.0189 1.6523 17.2454
EJM GDSC1; CTRP2; CTRP1 2.4239 5.3154 2.14 19.5178
ME1 GDSC1 2.4361 6.2498 1.0858 21.1777
REC-1 CTRP2 2.5637 4.7123 2.441 18.0148
RL GDSC1; CTRP2 2.6456 4.5483 2.5603 17.34
AMO1 GDSC1; CTRP2; CTRP1 2.6496 5.2467 2.4055 17.8761
WSU-NHL GDSC1 2.6564 6.9639 0.9404 21.1626
Granta-519 GDSC1; CTRP2 2.7129 4.8987 2.5631 17.1188
MOLP-2 CTRP2 2.8072 5.9126 2.367 17.5507
DG-75 GDSC1 2.8543 5.0218 2.0753 12.0726
JVM-3 GDSC1; CTRP2 2.8761 5.5193 2.5721 16.591
MHH-PREB-1 GDSC1 2.998 3.6284 2.8679 5.3816
Jiyoye GDSC1 3.0785 4.0595 2.7528 5.8692
OCI-Ly3 CTRP2 3.1298 4.5676 3.0774 14.0071
KY821 GDSC1 3.1989 5.2148 2.2927 8.9719
HD-MY-Z CTRP2 3.2808 5.5659 2.9975 13.8314
Raji GDSC1; CTRP2 3.4523 5.7278 3.1289 12.8436
U-698-M GDSC1 3.5206 5.3762 2.4797 6.3383
RC-K8 GDSC1 3.9164 5.2426 2.8289 2.5131
⏷ Show the Full List of 206 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE8 CTRP2 1.1399 4.0344 0.8992 22.5423
TE15 CTRP2 1.9781 4.6331 1.822 22.0236
TE-14 CTRP2 1.5563 3.7853 1.5024 24.4745
TE-15 GDSC1 1.8373 7.3339 -0.0066 30.3267
TE-4 GDSC1; CTRP2 1.9882 3.8446 1.9517 21.5439
TE-10 GDSC1; CTRP2 2.1273 4.2799 2.0465 20.7703
KYSE-140 GDSC1; CTRP2; CTRP1 2.2791 5.1791 2.0197 20.3908
TE-6 GDSC1; CTRP2 2.3045 6.1296 1.3962 16.977
KYSE-70 GDSC1; CTRP2 2.3134 4.9489 2.116 19.9415
KYSE-180 GDSC1; CTRP2 2.5791 5.1129 2.3646 18.2378
TE-1 GDSC1; CTRP2 2.6012 5.0264 2.4108 18.005
KYSE-150 GDSC1; CTRP2 2.6019 3.7986 2.5928 17.3704
T.T GDSC1 2.6842 3.7434 2.4899 9.7349
KYSE-410 GDSC1; CTRP2; CTRP1 2.7519 4.9252 2.5994 16.8689
KYSE-30 CTRP2 2.7655 3.9282 2.7552 16.2865
KYSE-270 GDSC1 2.911 5.0536 2.1129 11.5406
TE-9 GDSC1; CTRP2 2.9212 3.8918 2.9163 15.2332
COLO 680N GDSC1; CTRP2 3.1007 4.6851 3.0272 14.2738
OE21 GDSC1; CTRP2 3.2527 4.4197 3.2266 13.1001
TE-5 GDSC1; CTRP2 3.5878 4.9095 3.5116 11.0451
OE33 GDSC1; CTRP2 3.6759 4.753 3.6348 10.3376
TE-11 GDSC1; CTRP2 3.7041 4.8343 3.6517 10.1891
KYSE-510 GDSC1; CTRP2 3.7102 4.4927 3.6998 10.0045
KYSE-450 GDSC1; CTRP2; CTRP1 3.8947 15.453 -1.0454 26.4061
KYSE-520 GDSC1; CTRP2 4.2237 6.9544 3.4229 9.6396
OE19 GDSC1; CTRP2 4.2328 5.0853 4.1748 6.6947
EC-GI-10 GDSC1; CTRP2 4.8016 6.2693 4.3104 4.6392
TE-8 GDSC1 6.0331 8.6299 2.4771 1.4576
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 4.6841 8.2289 3.2424 9.3231
PaTu 8988s CTRP2 0.654 3.4615 0.5837 30.5281
HuP-T4 GDSC1; CTRP2; CTRP1 1.1712 3.0687 1.1553 26.9071
SNU-213 CTRP2 1.2861 4.2158 1.1524 26.5437
MZ-PC-1 GDSC1 1.6476 4.8212 0.9573 25.9516
BxPC-3 GDSC1; CTRP2 1.9997 3.9508 1.9531 21.5014
PK-59 CTRP2 2.0019 4.6425 1.8459 21.865
TCC-Pan2 CTRP2 2.0034 4.7184 1.8314 21.9113
Panc 08.13 GDSC1; CTRP2 2.1125 3.925 2.0747 20.7216
KP-3 GDSC1; CTRP2; CTRP1 2.1326 5.7936 1.6757 22.0753
Capan-2 GDSC1; CTRP2; CTRP1 2.1563 4.2062 2.0881 20.5344
Panc 05.04 CTRP2 2.259 4.8315 2.0843 20.2224
Panc 10.05 GDSC1; CTRP2; CTRP1 2.3237 3.749 2.3087 19.2403
KP-2 GDSC1 2.4712 3.333 2.3966 11.5499
L3.3 CTRP2 2.5136 5.1073 2.2946 18.6887
SUIT-2 GDSC1; CTRP2; CTRP1 2.6179 5.8644 2.1786 18.8002
HuP-T3 GDSC1; CTRP2 2.7807 5.6321 2.4325 17.3857
QGP-1 GDSC1; CTRP2; CTRP1 2.9115 6.0287 2.4383 16.9838
CFPAC-1 GDSC1; CTRP2; CTRP1 2.9181 4.9916 2.7648 15.7676
Capan-1 GDSC1; CTRP2 2.9632 4.6794 2.8798 15.2221
HPAC GDSC1; CTRP2; CTRP1 2.9645 4.3668 2.9277 15.0532
Hs 766T GDSC1; CTRP2 2.979 4.8022 2.8732 15.1952
MIA PaCa-2 GDSC1; CTRP2 2.9821 3.6539 2.9817 14.8133
YAPC GDSC1; CTRP2 3.1431 5.218 2.9521 14.4083
PaTu 8988t GDSC1; CTRP2 3.2015 4.0547 3.1971 13.3674
Panc 03.27 GDSC1; CTRP2; CTRP1 3.2224 5.1411 3.0592 13.782
KP-4 GDSC1; CTRP2 3.2838 5.1604 3.1211 13.3724
SNU-410 CTRP2 3.3518 5.1701 3.1927 12.9077
PaTu 8902 GDSC1; CTRP2; CTRP1 3.4779 5.0936 3.3501 11.958
HPAF-II GDSC1; CTRP2 3.4927 5.5038 3.248 12.2842
AsPC-1 GDSC1; CTRP2 3.5936 5.6306 3.3153 11.7399
PK-45H CTRP2 3.6787 5.4895 3.4548 10.974
DAN-G GDSC1; CTRP2 3.8017 20.1949 -3.4865 31.8883
PL4 GDSC1 3.864 5.8192 2.5179 4.9824
SW1990 GDSC1; CTRP2 3.9417 5.302 3.7996 8.9301
SU.86.86 GDSC1; CTRP2 4.0113 5.5811 3.3282 4.1355
Panc 02.03 GDSC1; CTRP2 4.1409 5.6787 3.8884 8.0204
PSN1 GDSC1; CTRP2 4.4468 8.7065 2.7908 11.7114
Panc 04.03 GDSC1; CTRP2 6.6276 14.8968 1.4909 12.7596
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 76 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 3.4373 5.6634 3.1349 12.8647
Hs 940.T GDSC1; CTRP2 -0.185 1.912 -0.1916 35.8945
Hs 852.T CTRP2; CTRP1 0.3443 1.9946 0.342 32.3608
Hs 934.T CTRP2 0.7385 2.7159 0.7261 29.7728
Hs 688(A).T CTRP2 1.3649 2.4681 1.3644 25.5675
LOX-IMVI GDSC1; CTRP2 1.3676 2.4527 1.3672 25.5492
MZ-MEL-2 GDSC1 1.5675 4.493 1.0083 26.0611
A-375 GDSC1; CTRP2; CTRP1 1.6195 3.8242 1.5649 24.0568
WM1552C GDSC1 1.6484 3.8781 1.3277 23.4834
MDA-MB-435S CTRP2 1.8605 4.4076 1.7382 22.6873
G-mel GDSC1 1.9121 4.8951 1.1994 22.9478
WM35 GDSC1 1.9678 3.5222 1.7926 18.5166
Hs 895.T CTRP2 2.0467 3.9388 2.0041 21.1755
COLO 792 GDSC1; CTRP2 2.1231 4.5062 2.0039 20.9312
WM1799 CTRP2 2.1488 4.7416 1.9844 20.9184
RPMI-7951 GDSC1; CTRP2 2.2262 4.123 2.1733 20.0171
CHL-1 GDSC1 2.2773 4.1113 1.912 16.0136
IGR-37 GDSC1; CTRP2 2.3547 3.0633 2.3546 18.9842
COLO 800 GDSC1; CTRP2 2.4303 4.9181 2.2507 19.1019
SK-MEL-3 GDSC1; CTRP2 2.5425 4.0791 2.5123 17.8363
WM793 GDSC1; CTRP2 2.5925 5.0644 2.3917 18.0999
WM983B CTRP2 2.7339 4.9494 2.5741 17.0148
Hs 839.T CTRP2 2.7538 5.3584 2.4874 17.2654
Mel JuSo GDSC1; CTRP2 2.8721 4.7441 2.7689 15.8968
A-431 GDSC1 2.9118 3.91 2.657 7.3676
IPC-298 GDSC1; CTRP2 2.9743 5.692 2.6232 16.1132
G-361 GDSC1; CTRP2; CTRP1 2.982 5.218 2.7762 15.5314
WM115 GDSC1; CTRP2 2.9896 4.5829 2.9247 14.9825
Mel Ho GDSC1; CTRP2 3.1316 4.4717 3.0925 13.9496
COLO 741 CTRP1 3.1539 5.9248 2.7369 32.2339
Hs 294T CTRP2 3.1866 5.1616 3.0147 14.0506
HMCB CTRP2 3.2402 4.0368 3.237 13.1063
SK-MEL-24 GDSC1; CTRP2 3.2782 4.1782 3.271 12.8668
Hs 944.T CTRP2; CTRP1 3.3137 6.0685 2.8557 14.2676
A2058 GDSC1; CTRP2 3.3365 4.1619 3.3314 12.4718
IGR-39 CTRP2 3.3756 5.2666 3.1922 12.837
SK-MEL-30 GDSC1; CTRP2 3.4237 4.062 3.4225 11.879
SH-4 GDSC1 3.4602 5.6303 2.3045 7.9212
SK-MEL-1 GDSC1; CTRP2; CTRP1 3.4764 5.1093 3.3445 11.9826
SK-MEL-5 GDSC1; CTRP2; CTRP1 3.4964 5.0109 3.3902 11.7587
MMAc-SF GDSC1 3.5359 5.0753 2.6414 5.019
VMRC-MELG GDSC1 3.6469 5.1906 2.6685 4.4568
DJM-1 GDSC1 3.6742 5.0242 2.77 3.5905
MeWo GDSC1; CTRP2 3.7058 5.0866 3.6003 10.3645
COLO 783 GDSC1 3.8993 6.2104 2.3524 6.1487
IGR-1 GDSC1; CTRP2 3.9096 5.2258 3.7864 9.0744
SK-MEL-31 CTRP2 3.9241 5.1162 3.8311 8.8699
HT-144 GDSC1; CTRP2 3.9564 5.1469 3.8585 8.6728
COLO 679 GDSC1 3.9564 7.0546 1.9802 8.8222
A101D GDSC1; CTRP2 3.9603 4.6676 3.9473 8.3507
CJM [Human melanoma] CTRP2 4.0021 4.5298 3.999 8.039
A-388 GDSC1 4.0299 5.9915 2.5488 4.3003
COLO 829 GDSC1; CTRP2 4.1338 6.2449 3.651 8.958
451Lu GDSC1 4.2102 6.5136 2.4198 4.8011
K029AX CTRP2 4.2838 7.1148 3.4069 9.558
UACC-257 GDSC1; CTRP2 4.3195 6.3098 3.8132 7.8335
WM266-4 CTRP2 4.3254 6.5058 3.7308 8.1478
WM88 CTRP2 4.341 5.7422 4.0771 6.7428
WT2-iPS GDSC1; CTRP2 4.3678 5.5425 4.1825 6.2662
RVH-421 GDSC1; CTRP2 4.3719 19.3986 -2.5946 29.0212
UACC-62 GDSC1; CTRP2 4.3749 5.0656 4.3335 5.6919
LB373-MEL-D GDSC1 4.5446 5.7529 2.9442 0.7493
GAK GDSC1 4.6361 6.1103 2.8431 1.1606
HMV-II GDSC1 4.6606 9.7172 1.1863 12.4267
SK-MEL-2 GDSC1; CTRP2 4.7492 5.1714 4.717 3.1723
CP66-MEL GDSC1 4.7701 6.4955 2.7495 1.5006
MZ-MEL-7 GDSC1 4.8513 6.3541 2.8447 0.9102
IST-MEL1 GDSC1 4.8634 12.1524 0.1422 18.0873
SK-MEL-28 GDSC1; CTRP2; CTRP1 5.1185 5.5638 4.9517 1.2704
CP50-MEL-B GDSC1 5.1232 7.0439 2.6941 1.3593
LB2518-MEL GDSC1 5.2928 6.6073 2.9298 0.2882
Hs 938.T GDSC1 5.3007 6.5547 2.9512 0.2325
M14 GDSC1 5.7394 7.3586 2.8309 0.356
WM278 GDSC1 6.5464 8.3581 2.776 0.213
Hs 936.T CTRP2; CTRP1 8.2696 17.8959 1.1997 11.2969
EquiPSC Line K2 GDSC1 5.4079 8.0999 2.3972 2.6258
⏷ Show the Full List of 76 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OACP4 C GDSC1 0.7172 3.6134 0.402 34.7944
OACM5.1 C GDSC1 0.975 4.9589 0.1946 34.1624
KYSE-50 GDSC1 1.6457 4.3353 1.1538 24.6724
KYAE-1 GDSC1 1.9252 6.3211 0.5604 26.9231
ESO-26 GDSC1 1.9509 4.1654 1.5449 20.3387
KYSE-220 GDSC1 2.1465 4.9811 1.4004 20.3651
FLO-1 GDSC1 2.3279 5.974 1.1156 21.4753
SK-GT-4 GDSC1 2.5579 3.9871 2.2579 12.0674
ESO-51 GDSC1 3.2181 5.2458 2.294 8.8881
TE-12 GDSC1 3.2846 7.7721 1.0883 17.6255
HCE-4 GDSC1 4.1443 6.0853 2.5792 3.7913
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 3.677 7.7107 1.4401 13.7429
Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KP-N-YS GDSC1 0.5715 3.3615 0.3157 36.2282
MHH-NB-11 GDSC1; CTRP2 0.6519 3.8527 0.5296 30.7154
GI-ME-N GDSC1 0.7298 5.1006 -0.1215 37.0995
KP-N-SI9s CTRP2 0.9189 2.6755 0.9114 28.557
IMR-5 GDSC1 1.0707 4.1777 0.5977 31.4627
CHP-212 GDSC1; CTRP2 1.2559 2.2317 1.2558 26.2912
CHP-126 GDSC1 1.2776 5.5942 0.2418 32.1223
LA-N-6 GDSC1 1.3621 5.6007 0.3256 31.2151
SK-N-BE(2) CTRP2 1.4302 3.5009 1.3966 25.2443
NB69 GDSC1 1.7186 4.5324 1.1518 24.2899
SiMa GDSC1 1.7213 4.2218 1.2786 23.4167
SJNB-17 GDSC1 1.8603 5.1035 1.0547 24.1876
NH-12 GDSC1 1.9719 4.6006 1.3882 21.3329
NH-6 CTRP2 1.9867 3.3707 1.9792 21.4564
SK-N-FI GDSC1; CTRP2 2.0063 3.5786 1.9902 21.3547
SJNB-12 GDSC1 2.22 6.0759 0.9631 23.0006
SJNB-7 GDSC1 2.3366 3.9393 2.0436 14.7573
Kelly GDSC1; CTRP2 2.3512 3.3591 2.3494 19.0129
SK-N-AS GDSC1; CTRP2 2.4637 4.8677 2.2988 18.828
SJNB-10 GDSC1 2.4702 5.63 1.4169 18.7097
NB1 GDSC1; CTRP2 2.4872 4.4693 2.403 18.3892
TGW GDSC1 2.6381 3.5495 2.5123 9.8208
CHP-134 GDSC1 2.698 4.0088 2.3943 10.364
SJNB-6 GDSC1 2.8923 3.7216 2.7184 7.009
SJNB-13 GDSC1 2.9039 4.8481 2.2064 10.8483
SK-N-DZ GDSC1; CTRP2 3.0215 3.8185 3.0198 14.5554
SK-N-BE(2)-M17 GDSC1 3.086 3.9758 2.8 5.4737
SK-N-SH GDSC1; CTRP2 3.1072 4.4038 3.0746 14.0898
SJNB-5 GDSC1 3.1221 3.9414 2.8512 4.9193
SK-N-MC-IXC GDSC1 3.1617 3.7669 2.9726 3.8113
SJNB-14 GDSC1 3.2354 4.2141 2.8228 4.6654
NB(TU)1 GDSC1 3.4412 5.212 2.4981 6.4649
KP-N-YN GDSC1; CTRP2 3.4561 4.4975 3.4332 11.7365
GOTO GDSC1 3.8026 6.3039 2.2357 7.3367
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-1079 CTRP2 -0.3362 2.1942 -0.3547 36.9382
HuH-28 CTRP2 0.7781 2.3924 0.7745 29.4802
SNU-478 CTRP2 1.4996 4.0137 1.4135 24.9615
SNU-308 CTRP2 2.2829 4.2591 2.216 19.6881
SNU-1196 CTRP2 2.8152 4.6739 2.7208 16.2442
HuCC-T1 GDSC1; CTRP2 3.1261 4.4776 3.0859 13.9901
SNU-869 CTRP2 3.4189 7.8651 2.201 16.5375
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 90 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC38 GDSC1 1.1632 3.4615 0.9334 28.8761
CAL-51 GDSC1; CTRP2 1.2049 2.7713 1.1997 26.6475
Hs 578T GDSC1; CTRP2 1.4152 2.5236 1.4147 25.2334
BT-474 GDSC1; CTRP2 1.6646 3.7555 1.6198 23.7238
Hs 578Bst CTRP2 1.6844 4.0419 1.607 23.7032
HMC-1-8 CTRP2 1.7086 3.9309 1.647 23.4882
MCF-7 GDSC1; CTRP2; CTRP1 1.721 4.4673 1.5763 23.6922
HCC1143 CTRP2 1.7263 4.8337 1.5038 23.9292
MDA-MB-453 GDSC1; CTRP2 2.0318 3.462 2.022 21.1639
BT-549 GDSC1; CTRP2 2.131 4.5428 2.0056 20.9003
HCC1395 GDSC1; CTRP2 2.132 4.4036 2.0316 20.8067
HCC1569 GDSC1 2.1924 6.8753 0.5526 25.664
HCC1599 GDSC1 2.3987 5.5309 1.3952 19.1944
EFM-19 GDSC1 2.4089 4.1766 2.0227 14.5393
CAL-85-1 GDSC1; CTRP2 2.4405 4.3884 2.3657 18.6672
MDA-MB-231 GDSC1; CTRP2 2.4497 4.4718 2.3622 18.6501
CAL-120 GDSC1; CTRP2 2.4794 4.9263 2.3023 18.7666
COLO 824 GDSC1 2.4904 4.2464 2.0772 13.7326
OCUB-M GDSC1 2.5348 4.0018 2.2275 12.4059
HCC1187 GDSC1 2.6129 5.133 1.7918 15.2967
DU4475 GDSC1 2.6356 3.411 2.5541 9.5457
CAL-148 GDSC1; CTRP2 2.692 3.8318 2.6839 16.7681
MDA-MB-157 GDSC1; CTRP2 2.8413 4.3602 2.7978 15.8949
HCC2157 GDSC1 2.8458 7.7627 0.7144 21.7922
Evsa-T GDSC1 2.9462 3.4998 2.8626 5.6899
AU565 GDSC1; CTRP2 2.9759 3.8507 2.973 14.8628
HCC1806 GDSC1; CTRP2 2.9883 4.0827 2.9769 14.8087
ZR-75-1 CTRP2 3.0334 5.563 2.7295 15.5475
SK-BR-3 CTRP2 3.07 4.4758 3.0264 14.3745
HCC1954 GDSC1; CTRP2 3.1534 5.1134 2.9911 14.2369
T-47D GDSC1; CTRP2 3.2596 6.3451 2.6912 15.0456
JIMT-1 GDSC1; CTRP2 3.2889 4.7798 3.2133 13.03
HCC1937 GDSC1; CTRP2 3.3102 5.1682 3.1479 13.1955
HDQ-P1 GDSC1; CTRP2 3.3256 4.6196 3.2794 12.6843
HCC70 GDSC1 3.3308 4.9351 2.5455 6.4855
MDA-MB-468 GDSC1; CTRP2 3.457 4.4638 3.4374 11.7198
MDA-MB-361 GDSC1; CTRP2 3.47 4.4269 3.4542 11.6204
KPL-1 CTRP2 3.4783 4.7785 3.418 11.7176
MFM-223 GDSC1 3.5221 5.379 2.4794 6.3356
HCC1500 GDSC1; CTRP2 3.5389 5.0308 3.4318 11.479
UACC-893 GDSC1 3.6442 5.5971 2.4658 6.0447
BT-20 GDSC1; CTRP2 3.8355 5.4312 3.6441 9.8148
MDA-MB-175-VII GDSC1 3.9063 5.91 2.5036 4.9728
HCC1428 GDSC1; CTRP2 3.9198 6.2237 3.4371 10.364
MDA-MB-415 GDSC1; CTRP2 3.9508 4.8945 3.9072 8.5187
MDA-MB-330 GDSC1 3.972 5.7963 2.6033 4.0422
EFM-192A GDSC1; CTRP2 4.012 5.191 3.9076 8.3268
HCC2218 GDSC1 4.0559 5.8813 2.6183 3.719
CAMA-1 GDSC1; CTRP2 4.1662 5.6131 3.9399 7.7542
YMB-1-E GDSC1 4.2179 6.9433 2.22 6.2659
UACC-812 GDSC1 4.3641 8.0601 1.782 9.1058
ZR-75-30 GDSC1; CTRP2 4.421 6.731 3.7217 7.9479
HCC1419 GDSC1; CTRP2 4.4546 5.4728 4.3013 5.5716
HCC202 CTRP2 4.5899 5.5892 4.4018 4.8097
BT-483 GDSC1 4.8147 6.5036 2.7678 1.3423
MRK-nu-1 GDSC1 4.8476 6.2834 2.8707 0.7936
MDA-MB-436 GDSC1 6.1381 8.0841 2.7233 0.4686
BT 416 CTRP2 1.3349 2.5944 1.3336 25.7699
BT 440 CTRP2 1.6053 3.375 1.5871 24.0281
BT 159 CTRP2 2.1601 3.9561 2.1218 20.4069
BT 271 CTRP2 2.1943 3.6492 2.1805 20.0965
BT 187 CTRP2 2.1981 3.7621 2.1777 20.0937
BT 504 CTRP2 2.2071 3.406 2.2026 19.9805
BT 139 CTRP2 2.2848 3.9757 2.2512 19.5616
BT 239 CTRP2 2.2913 5.4836 1.9459 20.6197
BT 245 CTRP2 2.3403 3.7228 2.3272 19.1235
BT 428 CTRP2 2.3577 4.6337 2.2334 19.3898
BT 131 CTRP2 2.5883 4.4115 2.5207 17.6598
BT 286 CTRP2 2.6526 4.2812 2.607 17.1568
BT 228 CTRP2 2.7496 3.2809 2.7496 16.358
BT147 CTRP2 2.7688 4.8883 2.6262 16.7219
BT 216 CTRP2 2.7788 4.2324 2.746 16.2742
BT 444 CTRP2 2.8622 4.2487 2.8323 15.7098
BT 328 CTRP2 2.8697 4.4362 2.8181 15.7341
BT 330 CTRP2 2.8727 4.1453 2.8526 15.6068
BT 482 CTRP2 2.8767 3.9525 2.8685 15.5401
BT 172 CTRP2 2.8946 4.7155 2.7989 15.7212
BT 231 CTRP2 2.9753 5.4397 2.7047 15.8107
BT 333 CTRP2 3.2923 4.7436 3.2235 12.9835
BT 359 CTRP2 3.4807 5.1959 3.3265 12.0339
BT 232 CTRP2 3.5532 5.1628 3.4144 11.4974
BT 112 CTRP2 3.6725 5.3316 3.4973 10.8368
BT164 CTRP2 3.8275 5.146 3.7181 9.5703
BT 145 CTRP2 4.159 4.9686 4.1186 7.1235
BT 340 CTRP2 4.215 4.9523 4.1821 6.7251
BT 422 CTRP2 4.3925 5.7422 4.1317 6.391
BT 179 CTRP2 4.4074 5.1558 4.3481 5.5393
BT 320 CTRP2 4.4981 6.5385 3.8876 7.0879
BT 224 CTRP2 4.5065 5.0513 4.4789 4.769
BT 498 CTRP2 4.6735 5.1169 4.647 3.655
⏷ Show the Full List of 90 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 1.5942 3.0068 1.5895 24.0569
Cancer Drug Sensitivity Data Curated from 67 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DK-MG GDSC1; CTRP2 -1.663 0.1512 -1.6634 45.7026
KS-1 [Human Krukenberg tumour] GDSC1 0.4112 3.1343 0.2 37.9276
KNS-60 CTRP2 0.6783 4.617 0.2285 26.6139
D-247MG GDSC1 0.8386 2.565 0.7773 31.8505
KG-1-C CTRP2 0.9909 2.7346 0.9832 28.0787
SNU-466 CTRP2 1.3958 3.5164 1.3594 25.4825
D-392MG GDSC1 1.4217 3.3721 1.2407 25.3575
42-MG-BA GDSC1; CTRP2 1.5884 3.0023 1.5838 24.0948
M059K CTRP2 1.6422 2.3481 1.6422 23.7219
D283 Med GDSC1; CTRP2 1.6661 2.3364 1.6661 23.5631
D-336MG GDSC1 1.7288 3.7143 1.4709 22.0583
D-566MG GDSC1 1.7488 3.0707 1.6709 20.5946
D-502MG GDSC1 1.7873 4.465 1.2516 23.2463
SNU-1105 CTRP2 1.8254 4.0072 1.7618 22.7185
SNU-201 CTRP2 1.9196 3.7454 1.8885 21.9817
SNB-75 GDSC1; CTRP2 1.9338 3.4671 1.9212 21.825
GMS-10 CTRP2 1.9355 3.1808 1.932 21.7833
LN-229 GDSC1; CTRP2; CTRP1 1.9966 4.7448 1.8182 21.9788
SF539 GDSC1; CTRP2 2.0003 2.9778 1.9996 21.3432
SF268 GDSC1; CTRP2 2.0615 3.402 2.0546 20.9567
GI-1 GDSC1 2.1199 3.6989 1.9 16.9313
KNS-81 CTRP2 2.1727 5.2623 1.6184 17.7898
ONS-76 GDSC1; CTRP2 2.1811 5.3895 1.8536 21.2856
CAS-1 GDSC1 2.2246 7.7292 0.1674 27.614
H4 GDSC1 2.2319 4.0942 1.871 16.5441
PFSK-1 GDSC1 2.3817 5.2313 1.5199 18.3738
D-423MG GDSC1 2.3859 4.9011 1.6774 17.2003
SW1088 GDSC1; CTRP2 2.3864 4.1513 2.3399 18.9301
SNU-489 CTRP2 2.3882 3.2903 2.3874 18.7638
LN-18 GDSC1; CTRP2 2.4017 3.0771 2.4016 18.6716
GOS-3 CTRP2 2.4508 4.5955 2.3415 18.7186
GaMG GDSC1; CTRP2; CTRP1 2.5097 4.0406 2.4813 18.0486
YH-13 GDSC1; CTRP2 2.5606 3.6 2.5571 17.6261
NMC-G1 GDSC1; CTRP2 2.5887 4.5291 2.5022 17.7224
SF126 GDSC1; CTRP2 2.667 3.4742 2.6663 16.9097
SNU-626 CTRP2 2.6819 3.5788 2.6803 16.8134
KALS-1 GDSC1; CTRP2 2.7467 4.9831 2.58 16.9542
A-172 GDSC1; CTRP2 2.7511 3.7957 2.7457 16.3657
SK-MG-1 GDSC1 2.7536 3.4603 2.6674 8.1062
AM-38 GDSC1 2.7649 4.26 2.3505 10.3691
M059J GDSC1 2.7803 3.6014 2.647 8.1052
MOG-G-CCM GDSC1 2.7905 4.8413 2.102 12.1458
U-251MG GDSC1; CTRP2 2.8631 3.8939 2.8568 15.6242
T98G GDSC1; CTRP2 2.927 4.2085 2.9041 15.2552
DBTRG-05MG GDSC1; CTRP2 2.9516 4.7392 2.856 15.3417
8-MG-BA GDSC1; CTRP2 2.9777 5.2121 2.7731 15.5554
Onda 11 GDSC1 2.9921 5.8034 1.8173 13.4818
GB-1 GDSC1; CTRP2 3.1881 4.3182 3.1683 13.5084
Hs 683 GDSC1; CTRP2 3.1925 4.1622 3.1835 13.4427
KINGS-1 GDSC1 3.3425 6.5393 1.7532 12.6162
MOG-G-UVW GDSC1 3.4953 4.9365 2.6787 4.8597
TM-31 CTRP2 3.4989 5.1739 3.3523 11.8857
U-118MG GDSC1; CTRP2 3.5741 4.7893 3.5193 11.0617
LN-405 GDSC1 3.6186 4.9351 2.7733 3.7289
D-542MG GDSC1 3.6188 5.5163 2.4864 5.9646
U-87MG ATCC GDSC1; CTRP2 3.6748 5.4857 3.4519 10.9965
YKG-1 GDSC1; CTRP2 3.687 5.8946 3.321 11.4515
CCF-STTG1 CTRP2 3.744 4.9048 3.6818 9.9582
Becker GDSC1; CTRP2 3.7539 6.6943 3.0644 12.2636
Onda 10 GDSC1 3.7901 5.7645 2.4917 5.397
KNS-42 GDSC1; CTRP2 3.8007 4.9517 3.734 9.597
Daoy GDSC1; CTRP2 3.8407 5.9816 3.4516 10.5245
KNS-81-FD GDSC1 4.2005 6.1296 2.5941 3.5519
SF295 GDSC1; CTRP2; CTRP1 4.2479 5.564 4.0457 7.1229
LNZTA3WT4 GDSC1 4.7046 7.1119 2.4474 3.5067
D-263MG GDSC1 4.7469 6.1163 2.8916 0.7945
SW1783 GDSC1 5.6333 7.6512 2.6819 0.9235
⏷ Show the Full List of 67 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1 3.3549 5.5292 2.2686 8.5777
TGBC24TKB GDSC1 3.392 4.5843 2.7717 4.4814
TGBC1TKB GDSC1 5.4804 7.5069 2.6719 1.098
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HEC-1-B CTRP2 0.3072 3.4607 0.2159 32.8998
JHUEM-2 CTRP2; CTRP1 0.6088 2.3154 0.6047 30.6076
JHUEM-3 CTRP2 0.951 2.3197 0.9497 28.3229
JHUEM-7 CTRP2 0.9549 1.8031 0.9549 28.2926
RL95-2 GDSC1; CTRP2 1.5951 4.2339 1.4821 24.4193
ESS-1 GDSC1; CTRP2 1.7337 4.3575 1.6103 23.5339
HEC-1-A CTRP2 1.7407 4.6103 1.569 23.6554
HEC-151 CTRP2; CTRP1 1.9672 4.9637 1.7351 22.3636
EFE-184 CTRP2 2.7221 4.9061 2.5714 17.0607
HEC-6 CTRP2; CTRP1 2.7678 4.6526 2.6736 16.5589
JHUEM-1 CTRP2 2.777 4.4903 2.711 16.3999
KLE GDSC1; CTRP2; CTRP1 3.0363 5.3616 2.7946 15.3007
MFE-280 GDSC1 3.1327 7.8809 0.905 19.427
MFE-296 GDSC1; CTRP2 3.4814 5.6941 3.172 12.5988
HEC-251 CTRP2; CTRP1 3.6171 5.382 3.4217 11.2781
EN GDSC1; CTRP2 3.7582 5.4309 3.56 10.3525
HEC-265 CTRP2; CTRP1 3.7922 5.4285 3.5978 10.1131
HEC-59 CTRP2; CTRP1 3.8396 6.7662 3.121 11.817
MFE-319 GDSC1; CTRP2; CTRP1 3.8506 5.0509 3.7666 9.3263
AN3-CA GDSC1; CTRP2 3.9015 5.2197 3.7792 9.125
HEC-108 CTRP2; CTRP1 4.2736 7.2921 3.3132 9.9635
HEC-50B CTRP2 4.443 13.0672 0.6249 20.0856
Ishikawa (Heraklio) 02 ER- CTRP2; CTRP1 2.0698 5.4978 1.7001 22.1753
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 38 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RXF 393L GDSC1 0.41 4.4607 -0.2164 39.6326
CAL-54 GDSC1; CTRP2 1.0953 2.0079 1.0952 27.3593
KTCTL-140 GDSC1 1.1588 3.3883 0.9492 28.8028
KTCTL-21 GDSC1 1.4218 3.7749 1.1176 26.1687
TUHR14TKB CTRP2 1.4398 2.6699 1.4384 25.0726
UO-31 GDSC1; CTRP2 1.4477 2.8859 1.4435 25.0292
KTCTL-26A GDSC1 1.537 2.6627 1.5084 22.92
KTCTL-1M GDSC1 1.6315 3.4964 1.4339 22.8586
KMRC-2 CTRP2 1.6793 2.242 1.6793 23.4756
KTCTL-195 GDSC1 1.8669 4.7239 1.2267 22.9963
769-P GDSC1; CTRP2 2.1187 4.2171 2.0464 20.7982
TUHR4TKB CTRP2 2.1615 3.4414 2.1553 20.2895
TUHR10TKB CTRP2 2.233 3.8848 2.2048 19.8878
BFTC-909 GDSC1; CTRP2 2.2411 3.3127 2.2389 19.7464
OS-RC-2 GDSC1; CTRP2 2.3485 5.0163 2.1377 19.756
Caki-1 GDSC1; CTRP2 2.3567 5.1156 2.1212 19.7897
VMRC-RCW GDSC1; CTRP2; CTRP1 2.43 4.375 2.3565 18.7324
KMRC-20 GDSC1; CTRP2 2.4451 3.5392 2.4412 18.3957
KTCTL-13 GDSC1 2.5365 3.7164 2.3427 11.5659
NCC021 GDSC1 2.5503 4.5034 2.024 13.8393
ACHN GDSC1; CTRP2 2.6262 5.7615 2.2222 18.6149
VMRC-RCZ GDSC1; CTRP2 2.6352 4.4933 2.5582 17.3806
HA7-RCC GDSC1 2.7817 3.5891 2.6531 8.0543
LB1047-RCC GDSC1 2.7858 4.4278 2.2935 10.7033
TK-10 GDSC1 2.844 7.421 0.8825 20.7404
SW156 GDSC1 2.9194 4.1897 2.5364 8.2422
A-704 GDSC1 2.9437 3.6489 2.8024 6.1353
BB65-RCC GDSC1 3.0972 4.1745 2.7152 6.0776
SNU-1272 CTRP2 3.1261 4.6327 3.0634 14.0674
RCC10RGB GDSC1; CTRP2; CTRP1 3.216 5.3287 3.0002 14.0143
KMRC-1 GDSC1; CTRP2 3.3642 4.1662 3.3596 12.2863
A-498 GDSC1 3.5309 5.2982 2.5267 5.9353
LB2241-RCC GDSC1 3.8733 5.7555 2.5553 4.6702
Caki-2 CTRP2 3.8841 5.0814 3.7959 9.1186
786-O GDSC1; CTRP2 4.0529 5.7557 3.7651 8.7364
SN12C GDSC1 4.1737 7.205 2.0631 7.5611
LB996-RCC GDSC1 4.3897 6.8244 2.389 4.5921
SW13 GDSC1 5.4424 7.4232 2.6878 1.0621
⏷ Show the Full List of 38 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 60 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-175 GDSC1; CTRP1 0.2545 3.3907 0.1685 50.2692
KM12 GDSC1; CTRP2; CTRP1 0.3117 4.4466 0.0517 33.4069
NCI-H716 GDSC1; CTRP2 0.579 2.4238 0.5723 30.8145
SW48 GDSC1; CTRP2; CTRP1 0.6241 2.8232 0.6038 30.5599
LoVo GDSC1; CTRP2; CTRP1 1.1494 3.9996 1.0406 27.3667
NCI-H747 GDSC1; CTRP2 1.2182 2.8296 1.2118 26.5628
HT115 GDSC1; CTRP2; CTRP1 1.345 2.9156 1.3386 25.72
SNU-C2A CTRP2; CTRP1 1.6582 4.8838 1.4177 24.4439
CL-34 CTRP1 1.7542 3.5476 1.7308 49.3783
GP2d CTRP2; CTRP1 1.7846 3.568 1.7611 22.8539
SNU-407 GDSC1; CTRP2 1.8462 4.483 1.7088 22.835
HCT 116 GDSC1; CTRP2; CTRP1 1.9401 4.6811 1.7706 22.3231
LS513 GDSC1; CTRP2; CTRP1 1.9745 3.7623 1.9445 21.6129
SW948 GDSC1; CTRP2; CTRP1 1.9953 3.2321 1.9916 21.3861
SNU-C5 GDSC1; CTRP2; CTRP1 2.0866 4.6979 1.9262 21.3176
SK-CO-1 CTRP2; CTRP1 2.1325 4.3277 2.0446 20.7601
NCI-H508 CTRP2; CTRP1 2.1859 4.2593 2.1122 20.3565
LS411N GDSC1; CTRP2; CTRP1 2.2239 4.9455 2.0194 20.5612
SNU-1040 GDSC1; CTRP1 2.2396 4.1187 2.1881 30.4029
COLO205 GDSC1; CTRP2; CTRP1 2.246 3.4089 2.2421 19.7196
CL-11 GDSC1; CTRP2 2.3043 4.0694 2.2623 19.4606
C2BBe1 GDSC1; CTRP2; CTRP1 2.4229 4.0446 2.3898 18.6418
CCK-81 GDSC1; CTRP2 2.4617 4.2767 2.4044 18.4659
HCT 8 CTRP2; CTRP1 2.4926 3.156 2.4925 18.0673
SNU-503 CTRP2 2.5454 4.5362 2.4543 18.0264
LS1034 GDSC1; CTRP2 2.5651 4.0443 2.5391 17.672
CL-40 CTRP1 2.6753 4.8439 2.5344 37.092
SNU-81 GDSC1; CTRP2; CTRP1 2.6818 5.4662 2.3768 17.8833
OUMS-23 CTRP2 2.7012 3.4504 2.7008 16.6811
SNU-61 GDSC1; CTRP2; CTRP1 2.7255 5.3659 2.4543 17.4703
T84 GDSC1; CTRP2 2.7289 3.8725 2.7201 16.5252
GP5d GDSC1 2.7658 6.2769 1.3787 17.6812
SW620 GDSC1; CTRP2; CTRP1 2.815 5.408 2.5395 16.892
COLO201 CTRP2 2.8255 4.0919 2.8073 15.9141
LS180 GDSC1; CTRP2; CTRP1 2.8492 4.6848 2.7556 16.0155
COLO 320 CTRP2; CTRP1 2.9518 6.0039 2.4907 16.6724
COLO 678 GDSC1; CTRP2; CTRP1 2.9717 5.5342 2.6715 15.9433
CW-2 GDSC1; CTRP2; CTRP1 3.0024 4.9119 2.875 15.1158
SW626 GDSC1 3.0164 4.0161 2.7131 6.4526
MDST8 GDSC1; CTRP2; CTRP1 3.0266 3.9819 3.0209 14.5346
SNU-C4 CTRP2; CTRP1 3.0373 6.7791 2.2816 17.228
SW1417 GDSC1; CTRP2 3.0407 5.2273 2.8377 15.1314
RKO GDSC1; CTRP2; CTRP1 3.0733 6.3282 2.4996 16.2948
SNU-C1 GDSC1; CTRP2 3.128 4.7008 3.0538 14.0944
COLO 320HSR GDSC1 3.2288 4.285 2.7818 5.0127
HCT 15 GDSC1; CTRP2 3.2394 4.6435 3.1834 13.291
SW837 GDSC1 3.2407 4.4568 2.7069 5.554
SW403 CTRP1 3.2945 5.7666 2.9447 29.8726
HT-55 GDSC1; CTRP2; CTRP1 3.5318 4.6162 3.4999 11.2642
LS123 GDSC1; CTRP2; CTRP1 3.5623 5.0737 3.447 11.3527
RCM-1 [Human ESC] GDSC1; CTRP2; CTRP1 3.5681 5.4094 3.3598 11.6503
HCC2998 GDSC1 3.776 6.464 2.1368 8.1834
DLD-1 CTRP2; CTRP1 3.8083 5.5896 3.562 10.1985
CaR-1 GDSC1 3.9658 5.6141 2.6858 3.4432
SNU-C2B GDSC1 4.011 9.1527 0.9839 15.7524
SW480 CTRP1 4.0728 7.5589 2.9914 24.697
HCC-56 CTRP2 4.1191 5.8265 3.8084 8.3864
HT-29 GDSC1; CTRP2; CTRP1 4.1278 9.9648 1.8795 16.113
SW1116 GDSC1 5.1271 6.6613 2.8451 0.6648
SW1463 GDSC1 5.633 7.305 2.8098 0.4657
⏷ Show the Full List of 60 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 3.8814 9.9153 0.5034 19.1612
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-182 CTRP2 -0.9011 1.6104 -0.912 40.668
HuH-6 CTRP2 0.6402 2.7666 0.6231 30.4421
JHH-1 GDSC1; CTRP2 1.0423 2.8117 1.0332 27.7416
Li-7 CTRP2 1.1693 3.274 1.1415 26.9597
SNU-761 CTRP2 1.7532 14.3874 -3.0702 32.8601
SNU-387 GDSC1; CTRP2 1.7717 3.9828 1.7077 23.0771
JHH-4 GDSC1; CTRP2 2.005 3.9884 1.9546 21.4793
SNU-886 CTRP2 2.0514 3.8348 2.0189 45.2775
HLF CTRP2 2.2647 3.6645 2.2523 19.624
Hep 3B2.1-7 GDSC1; CTRP2 2.4659 3.5079 2.463 18.2538
SNU-423 GDSC1; CTRP2 2.5066 4.2393 2.457 18.1416
SNU-878 CTRP2 2.5315 3.6993 2.5247 17.8311
SNU-475 GDSC1; CTRP2 2.7045 3.9531 2.6908 16.7035
Huh-7 GDSC1 2.7399 3.4837 2.6449 8.3383
JHH-2 GDSC1; CTRP2 2.7441 4.3976 2.6893 16.5798
JHH-7 GDSC1 2.8556 4.1572 2.4882 8.9036
Hep-G2 CTRP2; CTRP1 3.0201 5.4312 2.7561 15.4894
JHH-5 CTRP2 3.2713 4.9134 3.1672 13.2468
HuH-1 GDSC1; CTRP2 3.2955 4.5103 3.2618 12.8414
SNU-398 GDSC1; CTRP2; CTRP1 3.3664 5.6133 3.0749 13.2941
SNU-449 GDSC1; CTRP2; CTRP1 3.5523 4.3437 3.5451 11.0438
SK-HEP-1 GDSC1; CTRP2 4.1894 6.0298 3.8001 8.2267
JHH-6 GDSC1; CTRP2; CTRP1 4.4417 4.8949 4.432 5.1381
PLC/PRF/5 CTRP2 4.6507 5.1778 4.6081 3.8635
Hep-G2/C3A GDSC1 5.4977 6.5542 3.0201 0.0695
HLE GDSC1 6.2832 8.0837 2.7767 0.2838
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 218 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2795 GDSC1 0.0702 3.1675 -0.1802 42.0975
NCI-H2869 GDSC1 0.2075 2.8557 0.0425 40.1582
NCI-H1184 CTRP2 0.259 2.8234 0.2259 33.0298
LC-2/ad GDSC1 0.2641 1.9002 0.241 38.7833
NCI-H847 GDSC1 0.314 3.3047 0.0501 39.316
NCI-H146 CTRP2 0.3492 2.1378 0.3451 32.3342
NCI-H1703 GDSC1; CTRP2 0.3725 3.3632 0.2968 32.4157
SCLC-21H CTRP1 0.4288 1.4257 0.4288 68.2468
SBC-3 GDSC1 0.4297 2.3096 0.3755 36.8958
NCI-H211 GDSC1; CTRP2 0.4413 3.2143 0.3848 31.8955
EMC-BAC-1 GDSC1 0.6067 4.4778 -0.0111 37.475
NCI-H2731 GDSC1 0.7027 3.0918 0.528 34.2048
NCI-H2227 GDSC1 0.8561 5.0685 0.0247 35.6822
NCI-H1666 GDSC1; CTRP2; CTRP1 0.8902 3.0439 0.8666 28.8015
NCI-H446 GDSC1; CTRP2 0.9411 3.9185 0.8296 28.7596
EMC-BAC-2 GDSC1 1.0273 2.5186 0.9847 29.3787
NCI-H1341 CTRP2 1.0276 1.7469 1.0276 27.8089
NCI-H2087 GDSC1; CTRP2 1.1747 4.2351 1.0288 27.3254
NCI-H1734 GDSC1; CTRP2 1.2147 3.0497 1.2009 26.6108
NCI-H1944 GDSC1; CTRP2; CTRP1 1.2226 3.6951 1.1593 26.7253
NCI-H748 GDSC1 1.2625 4.1665 0.8081 29.0653
SK-MES-1 GDSC1; CTRP2 1.2797 2.7762 1.2755 26.1467
IST-SL1 GDSC1 1.3492 3.8112 1.0267 27.1809
HCC1833 CTRP2; CTRP1 1.3576 4.6424 1.146 26.3375
NCI-H526 GDSC1; CTRP2 1.3707 3.9713 1.2817 25.8281
HCC33 GDSC1; CTRP1 1.4238 3.3582 1.4002 38.5315
HCC2279 CTRP2 1.428 4.4418 1.2641 25.7052
VMRC-LCD CTRP2; CTRP1 1.4284 4.3266 1.2863 25.6274
Lu-99 CTRP2; CTRP1 1.4456 3.2815 1.4274 25.0903
NCI-H1435 GDSC1; CTRP2; CTRP1 1.469 4.6675 1.2615 25.5841
HOP-92 GDSC1; CTRP2 1.4718 2.9972 1.4655 24.8761
HCC15 GDSC1; CTRP2; CTRP1 1.4974 3.7299 1.4461 24.8577
NCI-H2085 GDSC1; CTRP2 1.5144 3.5293 1.4824 24.679
LCLC-97TM1 GDSC1; CTRP2; CTRP1 1.522 5.4181 1.1264 25.8904
NCI-H520 GDSC1; CTRP2 1.5398 3.8592 1.4764 24.6168
NCI-H1755 GDSC1; CTRP2; CTRP1 1.5595 4.0878 1.4669 24.5857
COR-L311 GDSC1 1.5727 3.0976 1.4738 22.932
Ms-1 GDSC1 1.584 2.7753 1.5443 22.4043
HCC1171 CTRP2 1.5998 5.3957 1.2177 25.3292
NCI-H358 GDSC1; CTRP2; CTRP1 1.6356 5.1926 1.3138 24.88
NCI-H647 GDSC1; CTRP2 1.6436 3.9808 1.5716 23.9562
DMS 454 CTRP2 1.6473 3.0925 1.6415 23.7076
SW1271 GDSC1; CTRP2 1.6573 4.5589 1.3125 19.26
NCI-H2009 GDSC1; CTRP2; CTRP1 1.6816 4.1982 1.5809 23.8017
CPC-N GDSC1 1.6841 3.7163 1.4217 22.6445
LXF 289 GDSC1; CTRP2; CTRP1 1.6899 2.8027 1.6889 23.4079
NCI-H1568 GDSC1; CTRP2; CTRP1 1.7064 3.2468 1.697 23.3264
COR-L105 GDSC1; CTRP2 1.7293 4.3002 1.6155 23.5298
NCI-H2073 CTRP1 1.7475 3.4557 1.7296 49.4685
NCI-H2804 GDSC1 1.7477 4.6878 1.1178 24.3614
SK-LU-1 GDSC1; CTRP2; CTRP1 1.7649 4.8629 1.539 23.6846
NCI-H1650 GDSC1; CTRP2 1.7668 3.5509 1.7437 22.9706
NCI-H1563 GDSC1; CTRP2 1.768 2.9727 1.766 22.8921
HCC44 GDSC1; CTRP2; CTRP1 1.7776 3.1759 1.7718 22.8408
DMS 114 GDSC1; CTRP2 1.7832 3.6152 1.7563 22.8746
HCC95 CTRP2 1.8295 3.7812 1.7908 22.6066
Lu-134-A GDSC1 1.8396 4.8774 1.1325 23.777
PC-14 GDSC1; CTRP2 1.8582 4.2509 1.6245 18.8246
NCI-H1048 GDSC1; CTRP1 1.8607 3.8262 1.8193 34.1919
A-549 GDSC1; CTRP2; CTRP1 1.8701 3.1421 1.8665 22.2182
EPLC-272H GDSC1; CTRP2; CTRP1 1.89 4.9137 1.6632 22.8575
NCI-H1963 CTRP1 1.8941 4.1411 1.8171 47.53
NCI-H596 GDSC1; CTRP1 1.9044 4.686 1.7308 34.3808
IST-SL2 GDSC1 1.9052 4.4817 1.3686 21.8163
NCI-H810 GDSC1; CTRP2; CTRP1 1.9066 3.8383 1.8664 22.0991
NCI-H209 GDSC1 1.9119 6.7551 0.3419 28.2046
Lu-139 GDSC1 1.9173 4.3628 1.4302 21.3222
LOU-NH91 GDSC1; CTRP2 1.9326 3.1322 1.9299 21.7997
DMS 53 GDSC1; CTRP2 1.9418 3.1229 1.9393 21.7382
NCI-H1373 CTRP2; CTRP1 1.9633 4.6342 1.8057 22.1271
EKVX GDSC1; CTRP2 1.973 3.738 1.9449 21.6164
NCI-H2171 GDSC1 1.9794 3.1471 1.9051 17.6896
NCI-H889 CTRP2 2.0206 4.3305 1.9239 21.5346
NCI-H1299 GDSC1; CTRP2; CTRP1 2.0365 5.1777 1.7553 22.0784
COR-L51 CTRP1 2.037 3.166 2.0349 45.3315
EBC-1 GDSC1; CTRP2; CTRP1 2.0401 4.0138 1.9889 21.2486
NCI-H441 GDSC1; CTRP2; CTRP1 2.0709 4.9845 1.843 21.6601
HCC366 CTRP2 2.0844 4.1844 2.0144 21.0183
CAL-12T GDSC1; CTRP2; CTRP1 2.1366 6.0402 1.5972 22.3493
NCI-H226 GDSC1; CTRP2 2.1428 5.5348 1.4783 17.1039
HCC2108 CTRP2; CTRP1 2.1457 4.8609 1.9542 21.0346
NCI-H1975 GDSC1; CTRP1 2.1463 3.7565 2.1242 31.1994
NCI-H1792 GDSC1; CTRP2; CTRP1 2.1488 4.5618 2.0212 20.7896
NCI-H23 GDSC1; CTRP2; CTRP1 2.1715 4.2127 2.1034 20.4326
NCI-H2126 CTRP2; CTRP1 2.1951 3.9967 2.1546 20.1814
NCI-H292 GDSC1; CTRP2 2.218 3.7832 2.197 19.9632
NCI-H2286 CTRP2; CTRP1 2.2227 3.722 2.2057 19.9185
NCI-H64 GDSC1 2.2437 3.3824 2.1348 14.6222
UMC-11 GDSC1 2.2757 4.6961 1.6592 17.8655
HOP-62 GDSC1; CTRP2 2.3093 3.8689 2.2858 19.3648
NCI-H1876 GDSC1; CTRP1 2.3392 4.4534 2.2464 29.6051
COLO 668 GDSC1; CTRP2; CTRP1 2.3447 4.4488 2.2531 19.3622
HCC1588 CTRP2 2.3959 3.9524 2.3697 18.7978
COR-L88 GDSC1; CTRP1 2.3998 4.2325 2.3443 28.7992
NCI-H1838 GDSC1; CTRP2 2.4106 4.5996 2.2972 18.9999
HCC1438 CTRP2 2.4199 3.8372 2.403 18.6068
NCI-H69 GDSC1; CTRP2 2.4225 4.547 2.3198 18.8836
LCLC-103H GDSC1; CTRP2; CTRP1 2.4329 3.7159 2.4229 18.4975
NCI-H196 GDSC1; CTRP2 2.4618 4.3696 2.3913 18.5109
NCI-H727 GDSC1; CTRP2; CTRP1 2.4884 5.2408 2.2313 18.993
NCI-H2106 CTRP2 2.4982 4.5205 2.4061 18.3435
DMS 273 GDSC1; CTRP2; CTRP1 2.5116 5.2401 2.2568 18.8308
Lu-135 GDSC1 2.5852 7.76 0.4828 24.2803
Calu-6 GDSC1; CTRP2; CTRP1 2.6281 4.4051 2.5642 17.3824
NCI-H1437 GDSC1; CTRP1 2.635 5.1961 2.4035 27.3375
NCI-H2405 GDSC1; CTRP2; CTRP1 2.636 6.0786 2.1234 18.9527
NCI-H2722 GDSC1 2.6462 4.2268 2.2455 11.7229
NCI-H187 GDSC1 2.6511 6.7841 1.0241 20.6336
NCI-H524 GDSC1 2.6555 8.2141 0.3211 24.8827
NCI-H1581 GDSC1; CTRP2 2.6623 4.9538 2.4951 17.5168
SHP-77 GDSC1; CTRP2; CTRP1 2.6831 3.9946 2.666 16.8574
HCC2935 CTRP2; CTRP1 2.7177 4.1173 2.6927 16.6539
NCI-H841 GDSC1; CTRP2; CTRP1 2.721 5.2979 2.4691 17.4304
NCI-H1436 GDSC1 2.7425 3.8434 2.5109 9.2833
NCI-H2803 GDSC1 2.7537 4.619 2.1723 11.773
COR-L95 GDSC1; CTRP2 2.7704 5.0697 2.5845 16.8649
PaCa-3 GDSC1 2.7734 4.4592 2.2666 10.9649
RERF-LC-Sq1 GDSC1 2.785 4.5705 2.2257 11.2233
NCI-H1573 GDSC1; CTRP2; CTRP1 2.7937 6.103 2.2846 17.8972
NCI-H1155 GDSC1; CTRP2 2.7961 4.1188 2.7747 16.1204
NCI-H1693 GDSC1; CTRP2 2.7967 4.9528 2.6417 16.5804
COLO 699 CTRP2; CTRP1 2.797 5.861 2.3738 17.5553
NCI-H3255 GDSC1; CTRP1 2.8109 4.7745 2.6965 24.9392
COR-L279 CTRP1 2.8134 4.0196 2.7996 34.3249
MOR/CPR CTRP2 2.8242 3.5486 2.8237 15.8633
NCI-H1355 GDSC1; CTRP2; CTRP1 2.8282 6.3691 2.2224 18.0335
Sq-1 CTRP2; CTRP1 2.8347 4.7745 2.7223 16.1776
NCI-H510A GDSC1 2.8391 4.3314 2.391 9.7174
LK-2 GDSC1 2.8407 3.6436 2.6955 7.4401
HCC78 GDSC1; CTRP2; CTRP1 2.8671 4.844 2.7428 16.0041
NCI-H2291 GDSC1; CTRP2 2.8773 5.2695 2.6477 16.3122
NCI-H1304 GDSC1 2.882 3.6915 2.72 7.0493
BEN GDSC1; CTRP2; CTRP1 2.9248 3.3965 2.9248 15.1929
NCI-H2373 GDSC1 2.9262 3.7265 2.7518 6.5935
HCC1359 CTRP1 2.927 4.1647 2.9078 32.743
NCI-H1694 GDSC1; CTRP2; CTRP1 2.9287 5.3769 2.6727 16.0669
NCI-H1930 CTRP1 2.9457 4.7712 2.8433 33.0519
COR-L303 GDSC1 2.946 3.5079 2.8595 5.7131
NCI-H2595 GDSC1 2.9626 4.6637 2.3512 9.4758
NCI-H1781 GDSC1; CTRP1 2.9694 5.2972 2.7404 23.9506
LUDLU-1 CTRP2 2.971 4.7334 2.8782 15.203
NCI-H2122 GDSC1; CTRP2; CTRP1 2.9721 4.0206 2.9634 14.9073
NCI-H2135 GDSC1 2.9837 5.8736 1.775 13.8379
SBC-1 GDSC1 2.9882 3.6988 2.828 5.7228
Calu-1 CTRP2 2.9964 4.1281 2.9826 14.7629
DMS 79 GDSC1; CTRP2 3.0136 5.1817 2.8206 15.2755
HARA [Human squamous cell lung carcinoma] GDSC1; CTRP2; CTRP1 3.0168 4.9426 2.8837 15.0404
NCI-H2081 GDSC1; CTRP1 3.0213 4.5943 2.9569 22.5414
RERF-LC-A1 CTRP2 3.0328 6.5677 2.3624 16.9307
NCI-H322M GDSC1 3.0464 6.9073 1.3163 16.971
LC-1/sq-SF CTRP2; CTRP1 3.0489 4.8083 2.9477 14.7148
NCI-H522 GDSC1; CTRP2; CTRP1 3.0493 5.2798 2.8324 15.1243
COR-L321 GDSC1 3.0591 3.7856 2.8621 5.1248
NCI-H650 GDSC1; CTRP2; CTRP1 3.0856 5.736 2.7291 15.3959
NCI-H1869 GDSC1; CTRP2 3.1535 6.5758 2.4868 16.1216
RERF-LC-Ad1 CTRP2 3.1586 4.354 3.1341 13.7204
NCI-H2347 GDSC1 3.1721 4.655 2.5476 7.0759
NCI-H1770 GDSC1 3.183 3.8758 2.941 3.9604
NCI-H1993 GDSC1 3.233 4.8463 2.5061 7.1634
NCI-H1105 CTRP2; CTRP1 3.234 4.5061 3.197 13.2615
NCI-H2228 GDSC1; CTRP2 3.2462 7.7343 1.5695 13.7594
NCI-H2141 GDSC1; CTRP1 3.2464 4.6414 3.1912 20.2094
HCC827 GDSC1; CTRP2; CTRP1 3.2636 4.6295 3.2116 13.1163
HCC4006 CTRP2; CTRP1 3.2637 4.9191 3.1577 13.304
NCI-H661 GDSC1; CTRP2; CTRP1 3.2656 6.1808 2.7616 14.7599
NCI-H1836 GDSC1; CTRP1 3.2768 4.5648 3.235 19.8301
Lu-99A GDSC1 3.2816 4.8858 2.5284 6.803
NCI-H513 GDSC1 3.3205 8.3765 0.8162 19.2722
NCI-H2030 GDSC1; CTRP2; CTRP1 3.3247 5.3051 3.1257 13.2315
T3M-10 CTRP2; CTRP1 3.326 5.1761 3.163 13.0929
COR-L23 GDSC1; CTRP1 3.4199 5.9161 3.0264 20.3214
NCI-H3122 GDSC1 3.4216 5.3108 2.4328 7.0476
NCI-H1688 GDSC1 3.4364 6.7906 1.7053 12.6362
NCI-H1648 GDSC1 3.4473 5.117 2.5505 6.0315
NCI-H838 GDSC1; CTRP2 3.4527 4.2608 3.4465 11.7031
NCI-H2818 GDSC1 3.4891 6.9091 1.6892 12.5681
LC-1/sq GDSC1 3.5047 6.5822 1.8651 11.1801
ABC-1 GDSC1 3.5107 5.6124 2.3541 7.3583
A-427 GDSC1 3.539 6.2664 2.0505 9.633
NCI-H290 GDSC1 3.5404 7.2481 1.5615 13.3362
NCI-H82 GDSC1; CTRP1 3.5911 5.0376 3.4871 16.9728
NCI-H2029 GDSC1; CTRP2; CTRP1 3.6289 4.7409 3.5862 10.6554
SW1573 GDSC1; CTRP2 3.6289 5.716 3.3238 11.6059
NCI-H1793 GDSC1; CTRP2; CTRP1 3.6506 6.1098 3.1992 12.0173
LK2 CTRP2 3.6542 4.6131 3.6301 10.4237
NCI-H1915 GDSC1; CTRP2; CTRP1 3.711 7.2193 2.7881 13.4684
DV-90 CTRP2; CTRP1 3.7114 5.1269 3.5964 10.3611
RERF-LC-MS GDSC1; CTRP2 3.7121 5.1032 3.6031 10.3353
ChaGo-K-1 GDSC1; CTRP2; CTRP1 3.7188 5.7865 3.3953 11.0806
NCI-H2369 GDSC1 3.7379 5.3107 2.6759 4.1303
NCI-H1623 GDSC1; CTRP2 3.7443 5.0453 3.6522 10.0613
KNS-62 CTRP2; CTRP1 3.7857 5.1304 3.6766 9.8468
NCI-H2172 GDSC1; CTRP2; CTRP1 3.8386 6.513 3.2302 11.3891
NCI-H2196 GDSC1; CTRP2 3.8484 6.0369 3.4379 10.5554
NCI-H2461 GDSC1 3.8601 5.4952 2.6719 3.821
RERF-LC-KJ GDSC1; CTRP1 3.8656 5.2178 3.7406 14.3054
IA-LM GDSC1; CTRP2 3.9717 5.1685 3.8696 8.5866
NCI-H2110 GDSC1; CTRP2; CTRP1 3.9846 7.1579 3.0911 11.5675
HCC1195 CTRP2; CTRP1 3.9883 7.5588 2.9086 12.2942
NCI-H1651 GDSC1; CTRP2 3.9919 5.4765 3.7993 8.7824
NCI-H2342 GDSC1; CTRP2; CTRP1 4.0647 5.1513 3.9755 7.9225
Lu-165 GDSC1 4.1304 6.3319 2.4535 4.7526
NCI-H1339 CTRP2 4.134 5.1238 4.058 7.4151
NCI-H2444 GDSC1; CTRP2 4.1577 6.9949 2.7473 6.4374
NCI-H2023 GDSC1; CTRP2; CTRP1 4.2541 5.6051 4.0372 7.1373
NCI-H2170 GDSC1; CTRP2 4.2547 6.4052 3.7047 8.4314
NCI-H460 GDSC1; CTRP2; CTRP1 4.2602 5.5688 4.0571 7.0452
NCI-H2591 GDSC1 4.2909 6.8521 2.3123 5.3917
NCI-H1092 GDSC1; CTRP2 4.3116 5.85 4.0026 7.1104
SBC-5 GDSC1; CTRP2 4.3473 5.6994 4.1008 6.6343
Lu-65 GDSC1; CTRP2; CTRP1 4.3877 5.3018 4.2858 5.8243
Calu-3 GDSC1; CTRP2; CTRP1 4.4172 5.2617 4.33 5.575
RERF-LC-Ad2 CTRP2 4.4536 5.3871 4.3301 5.4669
NCI-H322 CTRP2 4.5876 8.9419 2.8027 11.3544
NCI-H1395 CTRP2 4.6329 6.5474 4.0151 6.2448
NCI-H345 GDSC1 4.8367 5.8174 3.0387 0.1987
NCI-H720 GDSC1 5.3601 6.859 2.8654 0.4404
Hs 888.Lu CTRP2 1.9713 4.2692 1.8807 21.8413
⏷ Show the Full List of 218 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 2.4996 8.3044 0.1363 26.5359
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Yamato-SS CTRP2 -0.1247 4.1254 -0.3558 36.178
Aska-SS CTRP2 0.9943 2.7704 0.9856 28.0596
Rh41 GDSC1; CTRP2 0.3586 1.7586 0.358 32.2597
SW982 GDSC1; CTRP2 0.6872 2.4858 0.6807 30.0945
Rh18 CTRP2 0.7914 3.5247 0.722 29.6123
TTC-709 CTRP2 1.0548 2.6242 1.0506 27.642
BT-16 CTRP2 1.0917 2.5619 1.0888 27.3925
A-204 GDSC1; CTRP2 1.2184 3.6997 1.1544 26.7557
Rh30 GDSC1 1.4208 4.3259 0.918 27.4635
G-401 GDSC1; CTRP2; CTRP1 1.598 3.8048 1.5444 24.1963
Tm87-16 CTRP2 1.8264 2.877 1.8256 22.4999
TE 617.T CTRP2 1.9734 3.5749 1.9564 21.5761
GCT GDSC1; CTRP2 2.1644 3.3067 2.1615 20.259
KYM-1 GDSC1; CTRP2 2.2362 3.1472 2.2355 19.7744
Hs 729.T CTRP2 2.2818 4.0178 2.2439 19.5963
TE 441.T GDSC1; CTRP2 2.6165 4.5351 2.5312 17.5334
Hs 633.T GDSC1 2.6497 3.3419 2.5891 9.2275
RD GDSC1; CTRP2 2.7703 4.3863 2.7188 16.3942
BT-12 CTRP2 2.7996 3.6636 2.7979 16.0313
G-402 GDSC1; CTRP2 3.0291 4.4614 2.9847 14.6496
MES-SA GDSC1; CTRP2 3.2164 5.9244 2.8045 14.7369
RKN GDSC1; CTRP2; CTRP1 3.3939 5.8934 3.0067 13.4698
MFH-ino GDSC1 3.4029 4.5379 2.8037 4.1903
SW872 GDSC1 3.4645 4.6378 2.8032 3.9838
HT-1080 GDSC1; CTRP2; CTRP1 3.6013 5.4449 3.3849 11.4597
SK-LMS-1 GDSC1; CTRP2 3.7104 5.3452 3.5345 10.5881
VA-ES-BJ GDSC1 4.1251 5.6583 2.7653 2.5018
SK-UT-1 GDSC1; CTRP2 4.3354 5.7282 4.0768 6.7591
SW684 GDSC1 4.6751 6.0475 2.8865 0.892
EW-8 GDSC1 4.7182 7.3468 2.3492 4.1488
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SYO-1 CTRP2 0.579 2.1953 0.5763 30.8009
P-STS CTRP2 2.0049 3.6186 1.9864 21.3719
H-STS CTRP2 3.7118 5.0302 3.6203 10.2753
Cancer Drug Sensitivity Data Curated from 48 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 0.6979 2.7496 0.6831 30.0511
FU-OV-1 GDSC1; CTRP2 0.2562 4.8041 -0.0912 34.0373
OVKATE GDSC1; CTRP1 0.3922 2.8484 0.3626 48.9161
COV434 CTRP2; CTRP1 0.541 3.8563 0.4101 31.4792
RMUG-S CTRP1 1.167 5.1105 0.8244 55.8003
A2780 GDSC1; CTRP2; CTRP1 1.1726 5.0149 0.8555 27.9252
IGROV-1 GDSC1; CTRP2; CTRP1 1.4199 3.8336 1.3523 25.4282
OC 314 GDSC1; CTRP2 1.5675 2.6069 1.5671 24.2203
OVCAR-5 GDSC1; CTRP2 1.6006 4.1613 1.4997 24.341
SK-OV-3 GDSC1; CTRP2; CTRP1 1.6037 4.024 1.5232 24.2504
SNU-119 CTRP2 1.6233 4.372 1.4884 24.3074
RMG-I GDSC1; CTRP2; CTRP1 1.8794 5.1203 1.5993 23.1167
Caov-3 GDSC1; CTRP2; CTRP1 1.9006 3.5274 1.8838 22.0601
Kuramochi GDSC1; CTRP2 1.93 4.2109 1.8453 22.0954
SNU-840 CTRP2; CTRP1 2.0218 6.2807 1.3888 23.4451
OVCAR-8 GDSC1; CTRP2; CTRP1 2.051 3.4762 2.0411 21.0363
COV644 CTRP2; CTRP1 2.1649 3.8106 2.1396 20.3311
OVTOKO GDSC1; CTRP2 2.2814 5.1998 2.0166 20.3949
OVK18 GDSC1; CTRP2; CTRP1 2.3811 5.2922 2.0998 19.7923
COV362 CTRP2; CTRP1 2.4232 4.7362 2.2836 19.0079
ONCO-DG-1 CTRP2 2.4649 4.6895 2.3385 18.6845
JHOM-1 CTRP2; CTRP1 2.5282 4.5085 2.4405 18.1288
TOV-112D GDSC1; CTRP2 2.6044 6.7507 1.8356 20.1212
OV-90 GDSC1; CTRP2; CTRP1 2.65 5.1358 2.436 17.7653
OVCAR-4 GDSC1; CTRP2; CTRP1 2.655 5.8464 2.2251 18.52
OAW28 GDSC1; CTRP2 2.6624 4.819 2.5259 17.4074
OVSAHO CTRP2 2.747 7.6607 1.6068 20.5907
HEY A8 CTRP2; CTRP1 2.8317 5.0625 2.6531 16.4317
JHOC-5 CTRP2; CTRP1 3.0107 5.8571 2.6063 16.0703
TYK-nu GDSC1; CTRP2; CTRP1 3.0119 5.8259 2.6185 16.0212
OAW42 GDSC1; CTRP2; CTRP1 3.0371 3.8502 3.035 14.4532
ES-2 GDSC1 3.0435 3.6578 2.9029 4.8961
COV318 CTRP1 3.0697 4.8795 2.9554 31.3792
EFO-21 GDSC1; CTRP2; CTRP1 3.0885 4.9285 2.965 14.5302
SNU-8 CTRP2 3.1059 4.1917 3.0921 14.0345
OVISE GDSC1; CTRP2 3.1082 4.9487 2.9819 14.4089
OV7 CTRP2; CTRP1 3.2668 5.6249 2.963 13.9998
Caov-4 GDSC1 3.3138 6.9598 1.5189 14.4726
EFO-27 GDSC1; CTRP2; CTRP1 3.3794 6.6479 2.6947 14.7045
TOV-21G GDSC1; CTRP2 3.5792 5.0048 3.4817 11.1777
MCAS CTRP2 3.5805 5.4002 3.3762 11.5533
JHOS-4 CTRP1 3.5961 5.3528 3.4076 24.4584
JHOS-2 GDSC1; CTRP2 3.6948 5.1608 3.5695 10.5084
ES2 CTRP2 3.9298 7.8578 2.7107 13.2357
DOV13 GDSC1; CTRP2 4.082 5.4908 3.8921 8.1754
OVMANA CTRP1 4.1236 4.8365 4.1016 15.6714
OV56 GDSC1; CTRP2 4.4771 5.0689 4.4437 4.9845
OVCAR-3 GDSC1 6.1508 7.7973 2.8278 0.2223
⏷ Show the Full List of 48 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 3.7902 6.0377 3.3759 10.9542
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IST-Mes1 GDSC1; CTRP2 1.2488 2.9479 1.2397 26.3684
MSTO-211H GDSC1; CTRP2; CTRP1 1.2679 3.3113 1.2414 26.2999
JL-1 CTRP2 1.3873 16.9903 -4.1062 38.2813
NCI-H28 GDSC1; CTRP2; CTRP1 1.7666 3.9213 1.7097 23.0868
NCI-H2052 GDSC1; CTRP2; CTRP1 2.2854 4.9972 2.0738 20.1781
MPP 89 GDSC1; CTRP2 2.3773 3.4497 2.3744 18.8434
NCI-H2452 GDSC1; CTRP2 2.3973 5.029 1.9479 14.4177
ACC-MESO-1 CTRP2 2.8004 4.6323 2.7125 16.3203
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VCaP GDSC1; CTRP2 0.8111 2.1708 0.8101 29.2519
22Rv1 GDSC1; CTRP2 2.3567 6.6842 1.598 21.7078
LNCaP clone FGC GDSC1; CTRP2 3.186 7.3384 2.1994 17.1468
PC-3 GDSC1 3.4244 5.8767 2.1523 9.2396
DU145 GDSC1; CTRP2 4.0893 5.5373 3.884 8.1845
PaCa-3 CTRP2; CTRP1 4.5558 6.6949 3.8703 7.0193
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-15 CTRP2 0.7498 2.9793 0.725 29.7392
A-253 GDSC1; CTRP2 6.5615 8.73 4.4073 1.4861
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 2.2223 3.7935 1.9767 15.8386
Cancer Drug Sensitivity Data Curated from 42 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RERF-GC-1B GDSC1 -0.1499 4.8424 -0.9585 45.6463
HSC-39 GDSC1 0.0733 3.4246 -0.2454 42.2852
GSS CTRP2 0.4138 2.6012 0.3978 31.9441
SNU-16 GDSC1; CTRP2 0.868 1.5163 0.868 28.8705
HGC-27 GDSC1; CTRP2 0.8887 2.6299 0.8819 28.7554
ECC10 GDSC1; CTRP2 0.9909 3.3998 0.9451 28.2065
SNU-620 CTRP2 1.411 3.4119 1.3833 25.3525
Fu97 GDSC1; CTRP2; CTRP1 1.5159 2.6627 1.515 24.5648
SNU-1 GDSC1; CTRP2 1.5729 3.8622 1.5112 24.3907
KATO III CTRP2 1.6794 3.7191 1.6389 23.6106
SNU-216 CTRP2 1.7094 3.3123 1.6974 23.3152
KE-39 CTRP2 1.7788 4.7458 1.5811 23.4934
NCI-N87 GDSC1; CTRP2 1.8013 3.9738 1.7403 22.8699
IM95 GDSC1; CTRP2 2.1479 4.5481 2.0228 20.7868
23132/87 GDSC1; CTRP2 2.2735 4.1431 2.2212 19.7005
SNU-719 CTRP2 2.4013 4.7636 2.0503 13.99
GSU CTRP2 2.5316 3.1469 2.5316 17.8077
MKN1 GDSC1; CTRP2 2.5379 3.608 2.5338 17.7793
SNU-668 CTRP2 2.5775 4.8258 2.432 18.0033
GCIY GDSC1 2.619 4.1197 2.2648 11.7118
RF-48 GDSC1 2.629 7.2774 0.7608 22.427
Hs 746.T GDSC1; CTRP2 2.67 4.8093 2.5362 17.3475
AGS GDSC1; CTRP2; CTRP1 2.7208 3.6057 2.7192 16.5546
SNU-601 CTRP2 2.786 4.1115 2.7647 16.1874
NUGC-4 GDSC1; CTRP2; CTRP1 2.8445 4.2439 2.8141 15.829
ECC12 CTRP2 2.9367 4.9104 2.8039 15.5717
MKN74 CTRP2; CTRP1 2.9576 6.6167 2.2632 17.5175
SNU-5 GDSC1; CTRP2 2.98 5.3903 2.7247 15.7238
MKN28 GDSC1 3.0328 4.4652 2.5135 7.9176
NUGC-3 GDSC1; CTRP2 3.5618 4.7799 3.5077 11.1411
SH-10-TC CTRP2; CTRP1 3.6439 7.7495 2.4791 14.8687
TMK-1 GDSC1 3.7766 5.8103 2.4594 5.6865
LMSU CTRP2 4.0132 5.0644 3.9405 8.2057
OCUM-1 GDSC1 4.043 6.0769 2.5168 4.5052
HuG1-N CTRP2 4.1275 6.2159 3.6569 8.9512
SCH GDSC1 4.3337 7.7469 1.9124 8.2354
MKN7 GDSC1; CTRP2; CTRP1 4.4463 6.7363 3.7441 7.796
TGBC11TKB GDSC1 5.5141 7.8918 2.5348 1.7253
MKN45 GDSC1; CTRP2 7.0474 8.1258 4.8635 0.0763
SNG-M GDSC1; CTRP2; CTRP1 2.0381 4.7525 1.8616 21.6966
SNU-1077 CTRP2 2.0583 3.794 2.0295 21.0517
SNU-685 CTRP2 3.8094 5.9071 3.4472 10.6281
⏷ Show the Full List of 42 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
8305C GDSC1; CTRP2 0.5256 2.0315 0.5241 31.1525
CGTH-W-1 GDSC1; CTRP2 1.1786 2.8594 1.1708 26.8309
ML-1 [Human leukemia] GDSC1; CTRP2 1.2154 4.4377 0.8686 22.4127
SW579 CTRP2 1.2435 2.4785 1.2425 26.3769
BHT-101 GDSC1; CTRP2 1.5139 3.2259 1.5004 24.6202
KMH-2 GDSC1 1.6847 4.7016 1.0462 25.173
B-CPAP GDSC1; CTRP2 1.9526 3.8625 1.9125 21.7928
TT GDSC1; CTRP2 2.0089 3.9194 1.9662 21.4273
8505C GDSC1; CTRP2 2.1279 3.9769 2.0857 20.6341
CAL-62 GDSC1; CTRP2 2.1737 3.7365 2.154 20.2534
HTC-C3 GDSC1 2.2749 6.0198 1.0428 22.2141
TT2609-C02 GDSC1; CTRP2 2.933 5.8008 2.5417 16.5363
K5 GDSC1 3.1946 4.2959 2.7457 5.4336
FTC-238 CTRP2 3.3843 4.2082 3.3786 12.1563
IHH-4 GDSC1 3.4028 4.6536 2.7458 4.6471
ASH-3 GDSC1 4.5174 6.3362 2.6864 2.2746
WRO GDSC1 4.5193 6.9145 2.4275 4.0257
FTC-133 GDSC1; CTRP2 4.6936 6.0492 4.3085 4.9076
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-1214 CTRP2 1.1832 4.2024 1.0438 27.2465
SNU-1076 CTRP2 1.1988 3.5556 1.149 26.8377
JHU-011 GDSC1 1.2268 4.6359 0.5904 30.5632
YD-10B CTRP2 1.27 3.1224 1.2544 26.2493
YD-8 CTRP2 1.5279 3.4743 1.5006 24.5737
BICR 16 CTRP2 1.5577 3.0601 1.5512 24.3057
SCC-25 GDSC1; CTRP2 1.5754 3.4052 1.5545 24.236
KOSC-2 GDSC1 1.6719 3.9042 1.3438 23.2432
SNU-46 CTRP2 1.8354 3.4551 1.8204 22.4873
BICR 18 CTRP2 1.901 3.4262 1.8892 22.0404
SNU-899 CTRP2 1.9778 4.3629 1.8725 21.8485
BHY GDSC1; CTRP2 2.0145 3.739 1.9882 21.3343
PE/CA-PJ34 (clone C12) CTRP2 2.0177 4.1122 1.953 21.4436
PE/CA-PJ49 CTRP2 2.0557 3.3735 2.0495 20.9931
SNU-1066 CTRP2 2.2025 4.9968 1.9834 20.7555
PCI-04B GDSC1 2.3621 6.3034 0.9897 22.158
PCI-06A GDSC1 2.3649 4.3999 1.8812 15.798
BICR 6 CTRP2 2.4078 5.948 1.9226 20.3598
CAL-27 GDSC1; CTRP2 2.4206 4.9952 2.2216 19.2349
SAT [Human HNSCC] GDSC1 2.4372 4.9348 1.7129 16.6952
SCC-9 GDSC1; CTRP2; CTRP1 2.4454 4.3975 2.3696 18.638
BICR 31 GDSC1; CTRP2 2.4787 4.359 2.4111 18.3886
SNU-1041 CTRP2 2.5596 7.5769 1.4486 21.6933
SAS GDSC1 2.5889 4.5972 2.0198 13.6883
Detroit 562 GDSC1; CTRP2 2.6187 3.699 2.6137 17.2449
HSC-3 GDSC1; CTRP2 2.643 3.8509 2.6328 17.1006
SCC-4 GDSC1; CTRP2 2.6803 3.5549 2.6789 16.8233
DOK GDSC1 2.7266 6.3239 1.3197 18.2703
BB30-HNC GDSC1 2.8718 3.5657 2.7585 6.8256
NCI-H3118 GDSC1 2.8905 4.4723 2.3746 9.6107
OSC-19 GDSC1 2.9354 3.7594 2.7473 6.5813
JHU-022 GDSC1 2.9483 3.7849 2.7496 6.4998
HSC-2 GDSC1; CTRP2; CTRP1 3.0145 4.2127 2.9953 14.6607
SCC-15 GDSC1 3.1329 4.1661 2.7528 5.6338
BICR 10 GDSC1 3.2186 4.2143 2.8076 4.8515
Ca9-22 GDSC1 3.2592 5.7962 2.0544 10.6075
CAL-33 GDSC1 3.2688 5.531 2.1951 9.4724
BICR 22 GDSC1; CTRP2 3.3159 4.549 3.2787 12.7178
BB49-HNC GDSC1 3.3223 4.8005 2.6056 6.0428
PCI-15A GDSC1 3.3344 5.4638 2.2842 8.5297
KON GDSC1 3.5337 4.9433 2.7052 4.5257
LB771-HNC GDSC1 3.5404 4.8852 2.7392 4.2377
BICR 56 CTRP2 3.666 6.7833 2.9352 13.0028
SKN-3 GDSC1 3.691 5.5089 2.5445 5.2851
HO-1-u-1 GDSC1 3.6985 5.8505 2.3815 6.5297
HSC-4 GDSC1; CTRP2 3.7389 6.2318 3.2438 11.6034
FaDu GDSC1; CTRP2 3.8925 7.8936 2.6575 13.5407
PE/CA-PJ41 (clone D2) CTRP2 3.9315 5.3101 3.786 9.0101
PCI-38 GDSC1 4.0419 6.6478 2.2409 6.5912
PCI-30 GDSC1 4.1245 6.4193 2.4079 5.1079
PE/CA-PJ15 GDSC1; CTRP2 4.1527 5.5134 3.9609 7.7145
HO-1-N-1 GDSC1 4.315 6.8985 2.3061 5.3772
OSC-20 GDSC1 4.3584 7.2001 2.1916 6.1104
BICR 78 GDSC1 4.5293 8.8937 1.4937 10.701
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JMSU-1 CTRP2 0.5979 2.5431 0.5883 30.6986
253J CTRP2 0.9399 2.4264 0.9374 28.4005
U-BLC1 CTRP2 1.1434 2.5308 1.1413 27.046
5637 GDSC1; CTRP2; CTRP1 1.4544 3.2438 1.4384 25.0244
VM-CUB-1 CTRP2 1.5665 3.907 1.499 24.4533
HT-1376 GDSC1; CTRP2; CTRP1 1.5996 4.1886 1.4943 24.3627
RT-4 GDSC1; CTRP2; CTRP1 1.723 4.4152 1.5883 23.6444
RT-112 GDSC1; CTRP2 1.9022 3.8131 1.8642 22.1207
SW1710 GDSC1; CTRP2 2.468 4.3201 2.4052 18.4433
253J-BV CTRP2 2.5586 3.7658 2.5498 17.6572
TCCSUP GDSC1; CTRP2 2.6041 3.9482 2.587 17.3827
BFTC-905 GDSC1 2.6452 3.6726 2.4756 10.0426
BC-3C CTRP2 2.869 6.1684 2.3416 17.4686
647V GDSC1; CTRP2 2.9624 4.2601 2.9366 15.0295
639V GDSC1; CTRP2 2.968 3.854 2.9649 14.9158
KMBC-2 CTRP2; CTRP1 2.9953 5.0314 2.8392 15.2647
UM-UC-1 CTRP2 3.1648 5.2344 2.9712 14.2733
CAL-29 GDSC1; CTRP2 3.2565 4.386 3.234 13.0625
SCaBER CTRP2 3.322 5.4158 3.0897 13.3709
SW780 GDSC1 3.4871 4.7395 2.7704 4.1668
T24 GDSC1; CTRP2 3.6046 6.1008 3.1538 12.3186
J82 GDSC1; CTRP2 3.6919 4.8195 3.6411 10.2647
KU-19-19 GDSC1; CTRP2 3.8549 5.4954 3.6442 9.7574
UM-UC-3 GDSC1; CTRP2; CTRP1 3.8871 6.1585 3.4297 10.4812
HT-1197 GDSC1; CTRP2 4.4588 5.2016 4.3924 5.2236
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BPH-1 GDSC1 -0.1518 2.0548 -0.2111 44.0827
PA-1 GDSC1 -0.0411 2.9277 -0.2438 43.2291
Ca Ski GDSC1 0.8512 3.0436 0.701 32.2357
KGN GDSC1 1.0848 4.3077 0.5651 31.5605
OVMIU GDSC1 1.2594 4.348 0.7371 29.5135
JAR GDSC1 1.7229 4.5025 1.1685 24.1543
ME-180 GDSC1 1.7343 4.8703 1.0266 25.0357
NEC8 GDSC1 1.8777 4.1973 1.4546 21.361
OV17R GDSC1 1.8928 4.1324 1.496 20.9904
NCC-IT GDSC1 2.5994 7.3003 0.7226 22.7924
NT2-D1 GDSC1 2.7022 4.679 2.0936 12.6066
SW954 GDSC1 2.737 4.0347 2.4232 9.9581
HEY GDSC1 2.742 5.1801 1.8927 13.9591
SKN GDSC1 2.764 4.8304 2.0818 12.4177
ACC-OV7 GDSC1 2.8418 4.7882 2.1765 11.3482
HeLa GDSC1; CTRP2 2.8459 3.6867 2.8443 15.723
SW962 GDSC1 2.8803 3.7636 2.6883 7.2899
HT-3 GDSC1 2.9436 4.5849 2.3714 9.4013
SiSo GDSC1 3.0808 4.8182 2.3847 8.72
OVCA433 GDSC1 3.1188 4.9666 2.3455 8.873
LB831-BLC GDSC1 3.1246 4.0748 2.7894 5.3854
CAL-39 GDSC1 3.142 4.204 2.7428 5.6729
OMC-1 [Human cervical carcinoma] GDSC1 3.4029 4.7027 2.7214 4.8388
DoTc2 4510 GDSC1 3.4203 4.793 2.6904 5.0225
MS751 GDSC1 3.4502 4.6101 2.8057 4.0123
DSH1 GDSC1 3.4775 5.4861 2.3905 7.1859
JHOS-3 GDSC1 3.5291 5.2349 2.5567 5.7053
HEC-1 GDSC1 3.9143 5.4908 2.7104 3.3904
OVCA420 GDSC1 4.1087 6.1088 2.5451 4.1284
C-4-I GDSC1 4.2017 5.9567 2.6747 2.9737
SKG-IIIa GDSC1 5.1995 6.7156 2.8544 0.5768
SW756 GDSC1 5.3339 6.9065 2.8378 0.5473
JEG-3 GDSC1 5.3528 7.0102 2.807 0.6455
SiHa GDSC1 5.4746 6.5316 3.0198 0.0731
UWB1.289 GDSC1 5.6568 8.8139 2.2222 3.2855
C-33 A GDSC1 6.2627 8.2881 2.6977 0.4819
PEO1 GDSC1 6.417 8.331 2.7395 0.3195
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Fedratinib (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Remdesivir DMBFZ6L Moderate Increased risk of hepatotoxicity by the combination of Fedratinib and Remdesivir. 1D6YCoronavirus Disease 2019 [1D6YCoronavirus Disease 2019] [7]
Troleandomycin DMUZNIG Major Decreased metabolism of Fedratinib caused by Troleandomycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [8]
Pexidartinib DMS2J0Z Major Increased risk of hepatotoxicity by the combination of Fedratinib and Pexidartinib. Bone/articular cartilage neoplasm [2F7B] [8]
Tazemetostat DMWP1BH Major Decreased metabolism of Fedratinib caused by Tazemetostat mediated inhibition of CYP450 enzyme. Follicular lymphoma [2A80] [9]
Ripretinib DM958QB Moderate Decreased metabolism of Fedratinib caused by Ripretinib mediated inhibition of CYP450 enzyme. Gastrointestinal stromal tumour [2B5B] [7]
Avapritinib DMK2GZX Major Decreased metabolism of Fedratinib caused by Avapritinib mediated inhibition of CYP450 enzyme. Gastrointestinal stromal tumour [2B5B] [8]
Berotralstat DMWA2DZ Minor Decreased metabolism of Fedratinib caused by Berotralstat mediated inhibition of CYP450 enzyme. Innate/adaptive immunodeficiency [4A00] [8]
Pemigatinib DM819JF Major Decreased metabolism of Fedratinib caused by Pemigatinib mediated inhibition of CYP450 enzyme. Liver cancer [2C12] [8]
Lurbinectedin DMEFRTZ Major Decreased metabolism of Fedratinib caused by Lurbinectedin mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [10]
Pralsetinib DMWU0I2 Moderate Decreased metabolism of Fedratinib caused by Pralsetinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [11]
Selpercatinib DMZR15V Major Decreased metabolism of Fedratinib caused by Selpercatinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [8]
Ubrogepant DM749I3 Moderate Decreased metabolism of Fedratinib caused by Ubrogepant mediated inhibition of CYP450 enzyme. Migraine [8A80] [12]
Darolutamide DMV7YFT Minor Decreased metabolism of Fedratinib caused by Darolutamide mediated inhibition of CYP450 enzyme. Prostate cancer [2C82] [13]
Upadacitinib DM32B5U Moderate Decreased metabolism of Fedratinib caused by Upadacitinib mediated inhibition of CYP450 enzyme. Rheumatoid arthritis [FA20] [14]
Voxelotor DMCS6M5 Moderate Decreased metabolism of Fedratinib caused by Voxelotor mediated inhibition of CYP450 enzyme. Sickle-cell disorder [3A51] [8]
Larotrectinib DM26CQR Moderate Decreased metabolism of Fedratinib caused by Larotrectinib mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [7]
Fluticasone DMGCSVF Moderate Decreased metabolism of Fedratinib caused by Fluticasone mediated inhibition of CYP450 enzyme. Vasomotor/allergic rhinitis [CA08] [7]
⏷ Show the Full List of 17 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Sodium stearyl fumarate E00545 23665634 lubricant
Gelatin E00630 Not Available Other agent
Titanium dioxide E00322 26042 Coating agent; Colorant; Opacifying agent
Haematite red E00236 14833 Colorant
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Fedratinib 100 mg capsule 100 mg Capsule Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
2 FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (NDA) 212327
3 TH17 responses in cytokine storm of COVID-19: An emerging target of JAK2 inhibitor Fedratinib. J Microbiol Immunol Infect. 2020 Mar 11. pii: S1684-1182(20)30065-7.
4 FDA Approved Drug Products: Fedratinib Oral Capsules
5 Differences in gene expression and alterations in cell cycle of acute myeloid leukemia cell lines after treatment with JAK inhibitors. Eur J Pharmacol. 2015 Oct 15;765:188-97. doi: 10.1016/j.ejphar.2015.08.037. Epub 2015 Aug 20.
6 The antimicrobial drug pyrimethamine inhibits STAT3 transcriptional activity by targeting the enzyme dihydrofolate reductase. J Biol Chem. 2022 Feb;298(2):101531. doi: 10.1016/j.jbc.2021.101531. Epub 2021 Dec 23.
7 Cerner Multum, Inc. "Australian Product Information.".
8 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
9 Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
10 Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
11 Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
12 Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
13 Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
14 Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL.