Details of the Drug

General Information of Drug (ID: DM51LTG)

Drug Name
BMS-708163
Synonyms Avagacestat
Indication
Disease Entry ICD 11 Status REF
Alzheimer disease 8A20 Phase 2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 2 Molecular Weight (mw) 520.9
Logarithm of the Partition Coefficient (xlogp) 4
Rotatable Bond Count (rotbonds) 9
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 11
Chemical Identifiers
Formula
C20H17ClF4N4O4S
IUPAC Name
(2R)-2-[(4-chlorophenyl)sulfonyl-[[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide
Canonical SMILES
C1=CC(=CC=C1S(=O)(=O)N(CC2=C(C=C(C=C2)C3=NOC=N3)F)[C@H](CCC(F)(F)F)C(=O)N)Cl
InChI
InChI=1S/C20H17ClF4N4O4S/c21-14-3-5-15(6-4-14)34(31,32)29(17(18(26)30)7-8-20(23,24)25)10-13-2-1-12(9-16(13)22)19-27-11-33-28-19/h1-6,9,11,17H,7-8,10H2,(H2,26,30)/t17-/m1/s1
InChIKey
XEAOPVUAMONVLA-QGZVFWFLSA-N
Cross-matching ID
PubChem CID
46883536
CAS Number
1146699-66-2
UNII
TQ44WWY45Q
DrugBank ID
DB11893
TTD ID
D02JOH
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Gamma-secretase (GS) TT9W8GU APH1A_HUMAN ; APH1B_HUMAN ; PEN2_HUMAN ; NICA_HUMAN ; PSN1_HUMAN Modulator [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Alzheimer disease
ICD Disease Classification 8A20
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Gamma-secretase (GS) DTT APH1A; APH1B; NCSTN; PSENEN; PSEN1 1.47E-02 -0.09 -0.37
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1; GDSC2 8.4721 18.206 -0.3627 10.6985
ES8 GDSC1; GDSC2 3.9776 6.3996 2.316 4.9655
ES4 GDSC1; GDSC2 4.3812 8.1221 1.764 7.4102
EW-7 GDSC1; GDSC2 4.4268 6.5194 2.5526 2.6799
U-CH2 GDSC2 4.4298 8.4021 1.6354 7.8151
HOS GDSC1; GDSC2 4.5146 6.0325 2.8156 1.1842
A-673 GDSC1; GDSC2 4.5903 11.5546 0.2345 15.4942
EW-18 GDSC1; GDSC2 4.6912 7.6005 2.2165 4.1164
EW-3 GDSC1; GDSC2 4.7941 6.8924 2.5938 1.9134
TC-71 GDSC1; GDSC2 5.1291 6.8087 2.7896 0.7171
EW-13 GDSC1; GDSC2 5.3412 7.4907 2.6158 1.2081
NY GDSC1; GDSC2 5.3495 9.0378 1.9543 4.4556
CAL-78 GDSC1; GDSC2 5.3624 6.8117 2.8834 0.3077
G-292 clone A141B1 GDSC1; GDSC2 5.3836 7.8356 2.4954 1.6805
EW-24 GDSC1; GDSC2 5.3956 7.0042 2.8264 0.4383
ES1 GDSC1; GDSC2 5.4924 7.7795 2.5699 1.2576
SK-ES-1 GDSC1; GDSC2 5.5505 7.0991 2.8521 0.3065
CHSA0011 GDSC1; GDSC2 5.5622 8.0903 2.477 1.5779
EW-12 GDSC2 5.6313 7.4484 2.7237 0.4935
EW-22 GDSC1; GDSC2 5.6661 7.5059 2.7164 0.4962
NOS-1 [Human HNSCC] GDSC1; GDSC2 5.6767 8.8427 2.2202 2.6219
CHSA8926 GDSC1; GDSC2 5.7069 7.325 2.8307 0.2965
U2OS GDSC1; GDSC2 5.8185 8.3908 2.4753 1.348
CADO-ES1 GDSC1; GDSC2 5.8555 7.3961 2.8603 0.1958
HuO9 GDSC1; GDSC2 5.8917 8.1416 2.6042 0.8265
CHSA0108 GDSC1; GDSC2 5.9084 8.3627 2.5265 1.0825
SJSA-1 GDSC1; GDSC2 6.0312 7.8897 2.7522 0.3505
MHH-ES-1 GDSC1; GDSC2 6.0323 9.8959 1.9551 3.4593
ES7 GDSC1; GDSC2 6.0461 8.7844 2.4223 1.3619
CAL-72 GDSC1; GDSC2 6.0617 7.8693 2.7707 0.3014
SaOS-2 GDSC1; GDSC2 6.0722 7.9779 2.7362 0.3706
MG-63 GDSC1; GDSC2 6.1459 12.5803 0.8099 9.1847
ES6 GDSC1; GDSC2 6.15 11.6938 1.2215 7.0464
H-EMC-SS GDSC1; GDSC2 6.2922 12.1158 1.1139 7.3647
EW-1 GDSC1; GDSC2 6.3066 8.3679 2.6859 0.3956
EW-11 GDSC1; GDSC2 6.5463 9.168 2.4886 0.796
EW-16 GDSC1; GDSC2 6.6467 14.1263 0.4039 10.2941
SK-PN-DW GDSC1; GDSC2 7.1001 8.778 2.824 0.0565
ES5 GDSC1; GDSC2 7.7761 19.796 -1.5364 16.3813
HuO-3N1 GDSC1; GDSC2 9.4654 20.7127 -0.9144 11.4009
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 168 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1; GDSC2 4.9415 6.6451 2.7701 0.9436
TALL-1 [Human adult T-ALL] GDSC2 2.1372 12.5039 -2.2902 32.2906
MOLM-13 GDSC1; GDSC2 3.2802 4.9577 2.4913 5.6814
SUP-B8 GDSC1; GDSC2 3.3456 5.9383 2.0334 8.0869
ALL-SIL GDSC1; GDSC2 3.428 5.567 2.2865 6.2529
RCH-ACV GDSC1; GDSC2 3.4783 5.6066 2.3072 5.9841
HEL GDSC1; GDSC2 3.5289 4.7225 2.8111 2.9702
LP-1 GDSC1; GDSC2 3.5381 5.1897 2.5862 4.3561
KE-37 GDSC1; GDSC2 3.6537 5.2442 2.6213 3.5592
SKM-1 GDSC1; GDSC2 3.6889 4.8541 2.8359 2.1601
DoHH2 GDSC2 3.7373 7.0605 1.7866 8.5627
Jurkat GDSC1; GDSC2 3.8337 5.5212 2.614 3.1947
KY821 GDSC1; GDSC2 3.8615 7.1173 1.8783 7.9466
SUP-M2 GDSC1; GDSC2 3.8642 5.1418 2.8429 2.0283
BALL-1 GDSC1; GDSC2 3.9291 5.5517 2.6913 2.7964
Loucy GDSC1; GDSC2 3.95 5.799 2.5596 3.2768
PF-382 GDSC1; GDSC2 3.9612 6.1071 2.4194 4.1007
SU-DHL-5 GDSC1; GDSC2 4.0299 8.169 1.4856 9.9239
ML-2 GDSC1; GDSC2 4.047 5.631 2.7299 2.341
HL-60 GDSC1; GDSC2 4.1014 7.7248 1.7575 8.0976
IM-9 GDSC1; GDSC2 4.1171 6.2404 2.4602 3.5307
HC-1 GDSC1; GDSC2 4.124 8.3074 1.4877 9.6766
ATN-1 GDSC1; GDSC2 4.1246 6.4327 2.3739 4.0301
THP-1 GDSC1; GDSC2 4.1298 6.2768 2.4794 3.6511
A3/Kawakami GDSC1; GDSC2 4.193 6.4884 2.4205 3.8736
L-363 GDSC1; GDSC2 4.2428 5.6532 2.8352 1.4392
OCI-AML-3 GDSC1; GDSC2 4.2474 7.0413 2.193 5.1212
BONNA-12 GDSC2 4.2523 9.2844 1.076 11.5367
MHH-CALL-4 GDSC2 4.2615 8.9182 1.263 10.4218
P12-Ichikawa GDSC1 4.2933 5.6709 1.874 0.2951
SUP-T1 GDSC1; GDSC2 4.2977 7.617 1.9232 6.3779
P32/ISH GDSC1; GDSC2 4.3441 6.0651 2.7095 1.9537
SU-DHL-1 GDSC1; GDSC2 4.348 5.6458 2.8941 1.0099
WIL2 NS GDSC1; GDSC2 4.3712 5.9918 2.7572 1.661
SU-DHL-16 GDSC1; GDSC2 4.3784 7.7149 1.9587 6.2483
SIG-M5 GDSC1; GDSC2 4.3808 9.8182 0.9342 12.2713
OCI-Ly7 GDSC1; GDSC2 4.3838 6.4686 2.5208 2.6905
AMO1 GDSC1; GDSC2 4.3872 6.0034 2.7609 1.6191
DEL GDSC1; GDSC2 4.4287 5.4154 3.0247 0.3944
Namalwa GDSC1; GDSC2 4.4721 6.248 2.7002 1.8127
CMK GDSC1 4.4909 5.9984 1.832 0.3559
CCRF-CEM GDSC1; GDSC2 4.4944 9.7705 1.041 11.391
NCI-H929 GDSC1; GDSC2 4.5186 8.8868 1.4626 8.6422
MHH-CALL-2 GDSC1 4.5408 6.0667 1.8265 0.3486
NALM-6 GDSC1; GDSC2 4.544 8.0737 1.8988 6.2549
Mono-Mac-6 GDSC1; GDSC2 4.561 7.2377 2.3039 3.8514
MOLT-4 GDSC1; GDSC2 4.5715 6.7624 2.4977 2.5136
OCI-AML-2 GDSC1; GDSC2 4.5724 5.8473 2.9194 0.6728
KMS-11 GDSC1; GDSC2 4.594 6.9688 2.4474 2.9852
HT GDSC1; GDSC2 4.5986 5.8297 2.9381 0.5792
A4/Fukuda GDSC1; GDSC2 4.6168 6.4114 2.7071 1.5816
BC-1 GDSC1; GDSC2 4.6261 6.774 2.5535 2.3581
MOLM-16 GDSC1; GDSC2 4.6316 8.1764 1.8802 5.9341
MC116 GDSC1; GDSC2 4.6662 5.568 3.0633 0.1652
SR GDSC1; GDSC2 4.6783 8.3763 1.844 6.3015
CRO-AP2 GDSC1; GDSC2 4.7092 7.5088 2.2406 3.7079
LC4-1 GDSC1; GDSC2 4.7122 6.4413 2.7434 1.2924
697 GDSC1; GDSC2 4.7153 6.8441 2.5722 2.1302
TUR GDSC1; GDSC2 4.7577 6.2021 2.8626 0.7369
RL GDSC1; GDSC2 4.7712 6.3918 2.7926 1.0106
MLMA GDSC1; GDSC2 4.8088 7.2009 2.4669 2.5447
Raji GDSC1; GDSC2 4.8249 6.0239 2.9597 0.3579
OCI-Ly19 GDSC1; GDSC2 4.8271 8.662 1.8061 6.2249
NU-DUL-1 GDSC1; GDSC2 4.8789 6.7767 2.6864 1.3673
H9 GDSC1; GDSC2 4.8815 7.5259 2.3634 2.9849
U-698-M GDSC1; GDSC2 4.884 6.9296 2.6247 1.649
L-428 GDSC1; GDSC2 4.8933 6.5873 2.7709 0.9845
ARH-77 GDSC1; GDSC2 4.8938 6.6922 2.7285 1.1639
OCI-AML-5 GDSC1; GDSC2 4.9013 5.8981 3.0342 0.148
Hs 445 GDSC1; GDSC2 4.9198 6.4399 2.8415 0.6864
Karpas-422 GDSC1; GDSC2 4.9321 6.6593 2.7601 0.9932
Ku812 GDSC1; GDSC2 4.9369 6.7226 2.7367 1.0863
BL-41 GDSC1; GDSC2 4.9488 6.8195 2.7028 1.2197
Kasumi-1 GDSC1; GDSC2 4.9688 13.9299 -0.6543 18.6997
MOLT-16 GDSC1; GDSC2 4.971 11.0505 0.7308 11.7715
WSU-DLCL2 GDSC1; GDSC2 4.9714 6.2973 2.9174 0.4016
ALL-PO GDSC1; GDSC2 4.976 7.6193 2.3752 2.7813
CESS GDSC1; GDSC2 4.99 6.9248 2.6795 1.2796
DB GDSC1; GDSC2 4.992 6.547 2.8314 0.6688
GA-10 GDSC1; GDSC2 4.9987 10.5007 1.0156 10.148
TK [Human B-cell lymphoma] GDSC1; GDSC2 5.0005 7.3912 2.4881 2.1691
CML-T1 GDSC1; GDSC2 5.0094 6.3781 2.8698 0.4031
L-540 GDSC1; GDSC2 5.022 6.613 2.8188 0.6916
KM-H2 GDSC1; GDSC2 5.0448 6.6203 2.8259 0.6502
BC-3 GDSC1; GDSC2 5.0575 6.6344 2.8259 0.641
LAMA-84 GDSC1; GDSC2 5.0653 6.7421 2.7876 0.7724
SCC-3 GDSC1; GDSC2 5.0763 6.2807 2.9644 0.2328
BE-13 GDSC1; GDSC2 5.086 7.1669 2.6264 1.4138
KMOE-2 GDSC1; GDSC2 5.094 7.2294 2.6044 1.5034
JURL-MK1 GDSC1; GDSC2 5.0948 6.8453 2.7602 0.8513
CTV-1 GDSC1; GDSC2 5.1063 7.7127 2.3747 2.3876
SU-DHL-10 GDSC1; GDSC2 5.1117 6.1502 3.0228 0.1138
P31/FUJ GDSC1; GDSC2 5.1506 6.5306 2.903 0.3507
HH [Human lymphoma] GDSC1; GDSC2 5.1529 9.3147 1.708 6.1635
HDLM-2 GDSC1; GDSC2 5.1853 7.2151 2.6541 1.1949
Karpas-299 GDSC1; GDSC2 5.19 6.6774 2.8647 0.4365
Karpas-231 GDSC1; GDSC2 5.1956 6.3988 2.9671 0.1872
Ramos.2G6.4C10 GDSC1; GDSC2 5.2328 6.596 2.9112 0.2942
OPM-2 GDSC1; GDSC2 5.2504 6.9094 2.8027 0.5907
RC-K8 GDSC1 5.252 6.4381 2.974 0.1756
SUP-HD1 GDSC1; GDSC2 5.255 10.9336 1.0092 9.8688
KG-1 GDSC1; GDSC2 5.2576 7.4718 2.584 1.422
EHEB GDSC1 5.2874 11.6578 -0.1671 10.3163
EB2 GDSC1; GDSC2 5.2887 7.2373 2.6926 0.9506
NOMO-1 GDSC1; GDSC2 5.2895 6.769 2.8706 0.3709
YT GDSC1; GDSC2 5.3336 10.1439 1.4347 7.3567
Farage GDSC1; GDSC2 5.3372 9.8864 1.5573 6.6671
ST486 GDSC1; GDSC2 5.3445 6.874 2.8539 0.389
K-562 GDSC1; GDSC2 5.3872 6.8323 2.8854 0.2932
JJN-3 GDSC1; GDSC2 5.3907 6.9507 2.8441 0.3933
VL51 GDSC1; GDSC2 5.4173 9.7815 1.6555 5.9779
KCL-22 GDSC1; GDSC2 5.4336 7.0375 2.8293 0.4121
NK-92MI GDSC2 5.4365 7.1665 2.7498 0.5211
KMS-12-BM GDSC1; GDSC2 5.4447 6.839 2.9046 0.2319
Karpas-1106P GDSC1; GDSC2 5.455 7.5142 2.6254 0.9194
HAL-01 GDSC1; GDSC2 5.4629 7.4734 2.6773 0.8722
DG-75 GDSC1; GDSC2 5.4718 7.5709 2.6432 0.9901
Sc-1 GDSC1 5.4829 7.2285 2.7786 0.5849
Karpas-620 GDSC1; GDSC2 5.4982 6.8408 2.9235 0.1808
EJM GDSC1; GDSC2 5.515 7.4488 2.709 0.7265
MN-60 GDSC1; GDSC2 5.5307 7.4478 2.716 0.6934
BV-173 GDSC1; GDSC2 5.5321 6.9816 2.8868 0.2393
JVM-2 GDSC1; GDSC2 5.5328 7.5296 2.6857 0.7929
RS4;11 GDSC1; GDSC2 5.538 7.331 2.7629 0.5444
JVM-3 GDSC1; GDSC2 5.558 7.2991 2.7827 0.4775
Granta-519 GDSC1; GDSC2 5.5624 7.3999 2.7471 0.5774
EoL-1 GDSC1; GDSC2 5.5638 7.4547 2.7272 0.6376
Reh GDSC1; GDSC2 5.5644 13.7551 -0.1378 15.0266
KOPN-8 GDSC1; GDSC2 5.5737 8.5999 2.2703 2.5081
SU-DHL-8 GDSC1; GDSC2 5.5767 6.8265 2.9562 0.1136
L-1236 GDSC1; GDSC2 5.6098 7.9445 2.5577 1.2034
SU-DHL-4 GDSC1; GDSC2 5.6369 6.7948 2.9874 0.0691
WSU-NHL GDSC1; GDSC2 5.6412 6.9567 2.9346 0.1303
JeKo-1 GDSC1; GDSC2 5.6574 13.3082 0.1157 13.424
SK-MM-2 GDSC1; GDSC2 5.6604 7.44 2.7715 0.4576
QIMR-WIL GDSC1; GDSC2 5.6935 7.7587 2.6663 0.751
Jiyoye GDSC1; GDSC2 5.7041 7.7093 2.6894 0.6712
EM-2 GDSC1; GDSC2 5.7143 7.2457 2.8613 0.2326
MOLP-8 GDSC1; GDSC2 5.7554 7.0959 2.9273 0.1184
U266B1 GDSC1; GDSC2 5.775 7.5619 2.7719 0.4052
NKM-1 GDSC1; GDSC2 5.7762 7.8107 2.681 0.6548
Karpas-45 GDSC1; GDSC2 5.8281 12.438 0.6451 10.4217
GR-ST GDSC1; GDSC2 5.8382 8.1379 2.5829 0.934
VAL GDSC1; GDSC2 5.8423 12.1587 0.8142 9.7328
MV4-11 GDSC1; GDSC2 5.8734 7.4249 2.8568 0.1971
RPMI-8226 GDSC1; GDSC2 5.958 7.5502 2.8439 0.1972
MHH-PREB-1 GDSC1; GDSC2 5.9585 7.3482 2.9126 0.1025
ROS-50 GDSC1; GDSC2 5.9929 7.7907 2.7728 0.3198
CTB-1 GDSC1; GDSC2 6.0325 8.2166 2.6341 0.6512
Daudi GDSC1; GDSC2 6.0572 7.5641 2.8741 0.1323
CA46 GDSC1; GDSC2 6.0651 7.8696 2.7718 0.2979
RPMI-8402 GDSC1; GDSC2 6.0839 27.4253 -6.5124 31.4072
RPMI-8866 GDSC1; GDSC2 6.1878 7.508 2.937 0.0537
MM1.S GDSC1; GDSC2 6.2778 14.2197 0.0957 12.2592
MEG-01 GDSC1; GDSC2 6.2886 8.033 2.796 0.1952
MOLT-13 GDSC1; GDSC2 6.4461 21.4393 -3.2573 24.2335
GDM-1 GDSC1; GDSC2 6.4496 8.3278 2.7523 0.2262
OCI-M1 GDSC1; GDSC2 6.568 12.4294 1.1343 6.8112
P30/OHK GDSC1; GDSC2 6.6208 14.8374 0.0549 11.9907
JSC-1 GDSC1; GDSC2 6.7167 13.1051 0.9158 7.6655
PL-21 GDSC1; GDSC2 6.9953 8.9263 2.74 0.1387
SU-DHL-6 GDSC1; GDSC2 7.2077 16.8777 -0.5275 13.4825
RPMI-6666 GDSC1; GDSC2 7.8518 17.7873 -0.5458 12.44
SUP-B15 GDSC1; GDSC2 7.9328 16.0166 0.3107 8.6252
DND-41 GDSC1; GDSC2 8.5594 20.7114 -1.4634 14.795
ME1 GDSC1; GDSC2 8.9898 18.4517 -0.1746 9.1769
NB4 GDSC1; GDSC2 9.0656 18.6249 -0.2089 9.2113
MY-M12 GDSC1; GDSC2 10.0459 21.287 -0.8389 10.3246
⏷ Show the Full List of 168 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-12 GDSC1; GDSC2 4.8654 7.2352 2.4831 2.3787
KYSE-50 GDSC1; GDSC2 4.9392 7.0459 2.6038 1.6826
KYAE-1 GDSC1; GDSC2 6.0968 10.0071 1.9413 3.4433
FLO-1 GDSC1; GDSC2 6.1996 8.4776 2.6047 0.647
ESO-51 GDSC1; GDSC2 6.2054 14.0191 0.1713 12.238
OACP4 C GDSC1; GDSC2 6.2937 9.0227 2.4382 1.1148
SK-GT-4 GDSC1; GDSC2 6.3787 13.6062 0.4778 10.4226
KYSE-220 GDSC1; GDSC2 6.4582 13.4567 0.5975 9.6874
HCE-4 GDSC1; GDSC2 6.4836 8.3254 2.7652 0.1985
ESO-26 GDSC1; GDSC2 6.5371 8.1047 2.8575 0.0821
OACM5.1 C GDSC1; GDSC2 6.8739 8.8924 2.7094 0.1975
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1; GDSC2 6.3 8.3863 2.6768 0.4183
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-DZ GDSC1; GDSC2 4.3599 5.5753 2.9294 0.8348
MHH-NB-11 GDSC1; GDSC2 4.4062 6.4028 2.5934 2.4876
IMR-5 GDSC1; GDSC2 4.5853 6.7888 2.5237 2.5813
CHP-126 GDSC1; GDSC2 4.854 8.467 1.9151 5.5435
Kelly GDSC1; GDSC2 4.875 6.7371 2.7009 1.306
NB1 GDSC1; GDSC2 4.9413 6.6 2.788 0.8723
KP-N-RT-BM-1 GDSC2 4.9692 7.0555 2.5835 1.5481
CHP-134 GDSC1 5.0148 6.7424 2.7648 1.1252
SK-N-AS GDSC1; GDSC2 5.0175 7.1425 2.6027 1.5965
SJNB-6 GDSC1; GDSC2 5.0287 6.965 2.6816 1.2307
NB(TU)1 GDSC1; GDSC2 5.0358 6.6885 2.7955 0.7659
SK-N-MC-IXC GDSC1; GDSC2 5.0833 6.168 3.0066 0.1471
SJNB-13 GDSC1; GDSC2 5.1429 8.1648 2.227 3.3149
TGW GDSC1; GDSC2 5.1444 6.7891 2.8038 0.6568
KP-N-YS GDSC1; GDSC2 5.1617 9.2277 1.754 5.888
SJNB-14 GDSC1; GDSC2 5.2219 6.5566 2.9212 0.2752
SJNB-7 GDSC1; GDSC2 5.4094 10.8584 1.1471 8.7997
LA-N-6 GDSC1; GDSC2 5.4141 7.0885 2.8027 0.4955
SK-N-FI GDSC1; GDSC2 5.4555 7.6344 2.6108 1.1273
CHP-212 GDSC1; GDSC2 5.5757 10.5963 1.3762 7.2279
SK-N-SH GDSC1; GDSC2 5.7146 8.2738 2.4744 1.444
NB69 GDSC1; GDSC2 5.8098 10.891 1.3841 6.768
GOTO GDSC1; GDSC2 5.8657 9.1774 2.1752 2.6079
SJNB-10 GDSC1; GDSC2 5.8669 7.9821 2.6541 0.6843
SK-N-BE(2)-M17 GDSC1; GDSC2 5.8987 7.6285 2.795 0.3056
GI-ME-N GDSC1; GDSC2 5.9373 10.7468 1.5259 5.7998
NH-12 GDSC1; GDSC2 5.9517 7.8941 2.7202 0.4572
SJNB-17 GDSC1; GDSC2 6.0339 8.046 2.6971 0.4791
SiMa GDSC1; GDSC2 6.0715 7.9073 2.761 0.3179
KP-N-YN GDSC1; GDSC2 6.27 8.0821 2.7725 0.2375
SJNB-12 GDSC1; GDSC2 6.5518 8.8454 2.6084 0.4777
SJNB-5 GDSC1; GDSC2 6.6278 13.9215 0.4873 9.925
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1; GDSC2 5.7762 7.6174 2.7523 0.4542
Cancer Drug Sensitivity Data Curated from 52 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC202 GDSC1 3.6856 5.7648 1.5602 2.512
HCC1395 GDSC1; GDSC2 4.0382 8.0607 1.5198 9.4349
CAL-120 GDSC1; GDSC2 4.0596 6.5334 2.3087 4.8269
HCC2218 GDSC1; GDSC2 4.0925 8.1432 1.5194 9.3032
COLO 824 GDSC1; GDSC2 4.2111 5.9614 2.6783 2.3428
HCC1428 GDSC1; GDSC2 4.2771 6.8298 2.3138 4.3373
BT-549 GDSC1; GDSC2 4.288 7.2797 2.1061 5.5566
MDA-MB-231 GDSC1; GDSC2 4.3624 6.3149 2.6074 2.4827
HCC1806 GDSC1; GDSC2 4.4526 6.2416 2.6922 1.8825
DU4475 GDSC1; GDSC2 4.562 6.0968 2.8125 1.1439
BT-20 GDSC1; GDSC2 4.8413 8.8789 1.7128 6.7377
MFM-223 GDSC1; GDSC2 4.9046 6.666 2.7444 1.085
MDA-MB-468 GDSC1; GDSC2 4.9289 10.7391 0.8791 11.2881
EFM-192A GDSC1; GDSC2 4.9339 6.768 2.7167 1.1745
OCUB-M GDSC1; GDSC2 5.0198 6.7994 2.7445 0.9769
EFM-19 GDSC1; GDSC2 5.0619 7.0687 2.6551 1.3123
YMB-1-E GDSC1; GDSC2 5.0659 7.7239 2.3787 2.6341
Hs 578T GDSC1; GDSC2 5.1326 7.0079 2.7129 1.0035
MDA-MB-330 GDSC1; GDSC2 5.1346 7.6213 2.4598 2.136
HCC1937 GDSC1; GDSC2 5.1612 9.4528 1.6487 6.4823
Evsa-T GDSC1; GDSC2 5.1988 6.8878 2.7891 0.6695
MRK-nu-1 GDSC1; GDSC2 5.2668 6.515 2.9526 0.1933
HCC2157 GDSC1; GDSC2 5.2674 6.8402 2.8356 0.4794
CAL-51 GDSC1; GDSC2 5.2718 6.9296 2.8039 0.5734
HDQ-P1 GDSC1; GDSC2 5.3266 7.3588 2.6617 1.0381
BT-474 GDSC1; GDSC2 5.3952 7.5573 2.614 1.1669
UACC-893 GDSC1; GDSC2 5.3992 7.3486 2.6979 0.8455
JIMT-1 GDSC1; GDSC2 5.4074 6.9999 2.8327 0.4156
MDA-MB-175-VII GDSC1; GDSC2 5.5368 7.0262 2.8728 0.2664
MDA-MB-436 GDSC1; GDSC2 5.5607 9.1467 2.0261 3.7504
CAL-148 GDSC1; GDSC2 5.5677 7.024 2.885 0.2316
MDA-MB-453 GDSC1; GDSC2 5.6087 8.2161 2.416 1.618
HCC70 GDSC1; GDSC2 5.6564 7.4546 2.7646 0.4782
HCC1569 GDSC1; GDSC2 5.6644 12.6288 0.4738 11.8402
HCC1500 GDSC1; GDSC2 5.7105 7.6021 2.7319 0.5415
MDA-MB-361 GDSC1; GDSC2 5.7426 13.0269 0.3359 12.3694
HCC1419 GDSC1; GDSC2 5.7589 13.6687 0.0389 13.7779
UACC-812 GDSC1; GDSC2 5.7696 7.277 2.8705 0.2006
MDA-MB-415 GDSC1; GDSC2 5.7828 11.2949 1.1808 7.9059
CAMA-1 GDSC1; GDSC2 5.804 7.4306 2.8296 0.2665
MCF-7 GDSC1; GDSC2 5.8236 7.62 2.7697 0.3904
ZR-75-30 GDSC1; GDSC2 5.8302 7.5822 2.7857 0.3505
HCC1954 GDSC1; GDSC2 5.8989 12.254 0.8058 9.6676
HCC1599 GDSC1; GDSC2 5.9557 7.6004 2.7921 0.2194
MDA-MB-157 GDSC1; GDSC2 6.0086 13.6377 0.2224 12.3829
BT-483 GDSC1; GDSC2 6.0378 7.3502 2.9048 0.0632
AU565 GDSC1; GDSC2 6.0877 8.5471 2.5326 0.935
HCC1143 GDSC1; GDSC2 6.1611 11.5742 1.253 6.65
HCC1187 GDSC1; GDSC2 6.7998 14.6065 0.2763 10.6295
HCC38 GDSC1; GDSC2 8.0846 19.3287 -1.1175 14.3071
CAL-85-1 GDSC1; GDSC2 8.1817 16.1776 0.38 7.9565
T-47D GDSC1; GDSC2 10.2902 20.3598 -0.2993 7.9979
⏷ Show the Full List of 52 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 55 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D-245MG GDSC2 4.327 11.2469 0.1627 16.3084
SF295 GDSC1; GDSC2 4.4889 6.0246 2.8057 1.2615
Daoy GDSC1; GDSC2 4.5491 6.1772 2.7719 1.3504
KNS-42 GDSC1; GDSC2 4.6161 6.4535 2.6886 1.6744
U-118MG GDSC1; GDSC2 4.6709 6.3556 2.7586 1.2694
GI-1 GDSC1; GDSC2 4.7643 7.4657 2.3225 3.3948
H4 GDSC1; GDSC2 4.8742 6.8781 2.6415 1.5809
SNB-75 GDSC1; GDSC2 4.8787 7.0449 2.5728 1.9074
U-251MG GDSC1; GDSC2 4.9199 6.8673 2.669 1.4015
D-263MG GDSC1; GDSC2 4.9253 6.3519 2.8778 0.5548
LN-18 GDSC1; GDSC2 4.9664 7.1462 2.5752 1.7864
Hs 683 GDSC1; GDSC2 5.0049 6.0609 3.0153 0.1531
U-87MG ATCC GDSC1 5.0373 7.1418 2.6129 1.6903
A-172 GDSC1; GDSC2 5.0545 7.8018 2.3383 2.8598
YKG-1 GDSC1; GDSC2 5.0727 6.9674 2.7015 1.1043
SF539 GDSC1; GDSC2 5.115 6.5768 2.8718 0.457
LN-229 GDSC1; GDSC2 5.1286 7.7271 2.4112 2.384
SW1088 GDSC1; GDSC2 5.1533 7.4396 2.5462 1.703
GB-1 GDSC1; GDSC2 5.1634 6.6937 2.8479 0.5014
D-542MG GDSC1; GDSC2 5.2233 6.7044 2.8681 0.4097
SF126 GDSC1; GDSC2 5.3277 12.2752 0.4136 12.8633
YH-13 GDSC1; GDSC2 5.3629 7.0406 2.7998 0.5323
SF268 GDSC1; GDSC2 5.3719 7.6661 2.5593 1.4146
DK-MG GDSC1; GDSC2 5.3851 6.8596 2.8748 0.3188
D-247MG GDSC1; GDSC2 5.4669 7.6713 2.6013 1.1547
Becker GDSC1; GDSC2 5.4787 7.9497 2.4945 1.586
LN-405 GDSC1; GDSC2 5.4907 7.1872 2.797 0.4718
D-336MG GDSC1; GDSC2 5.492 7.5314 2.6674 0.886
MOG-G-CCM GDSC1; GDSC2 5.5339 9.1299 2.0186 3.8289
KALS-1 GDSC1; GDSC2 5.6119 9.7318 1.7942 4.8968
42-MG-BA GDSC1; GDSC2 5.6162 7.2021 2.8403 0.3084
SW1783 GDSC1; GDSC2 5.6321 7.9531 2.5644 1.1589
LNZTA3WT4 GDSC1; GDSC2 5.6378 8.0481 2.5293 1.2912
D-566MG GDSC1; GDSC2 5.686 7.2613 2.8454 0.2729
Onda 10 GDSC1; GDSC2 5.7917 7.8302 2.6801 0.6488
PFSK-1 GDSC1 5.8241 8.1179 2.5846 1.0384
AM-38 GDSC1; GDSC2 5.8453 7.4778 2.8283 0.2561
ONS-76 GDSC1; GDSC2 5.9773 7.5045 2.8664 0.1583
T98G GDSC1; GDSC2 5.9983 7.7556 2.7872 0.2887
D283 Med GDSC1; GDSC2 5.9996 7.2499 2.959 0.0544
M059J GDSC1; GDSC2 6.0248 7.7408 2.8021 0.2522
SK-MG-1 GDSC1; GDSC2 6.0463 7.809 2.7862 0.2758
MOG-G-UVW GDSC1; GDSC2 6.1029 7.8945 2.777 0.2761
Onda 11 GDSC1; GDSC2 6.2235 11.0957 1.534 5.3106
8-MG-BA GDSC1; GDSC2 6.2853 7.9283 2.8304 0.1473
KS-1 [Human Krukenberg tumour] GDSC1; GDSC2 6.3625 8.9479 2.4957 0.8804
D-423MG GDSC1; GDSC2 6.9968 14.9614 0.234 10.4818
KNS-81-FD GDSC1; GDSC2 7.2101 14.7166 0.4757 8.9926
DBTRG-05MG GDSC1; GDSC2 7.2948 15.6124 0.1164 10.5125
D-502MG GDSC1; GDSC2 7.3498 17.8304 -0.8847 14.6858
D-392MG GDSC1; GDSC2 7.8517 16.0422 0.2523 9.0078
NMC-G1 GDSC1; GDSC2 8.1545 26.3765 -4.4418 24.0445
GaMG GDSC1; GDSC2 8.5021 20.4904 -1.3964 14.6474
CAS-1 GDSC1; GDSC2 8.9872 20.5582 -1.1282 12.9016
KINGS-1 GDSC1; GDSC2 10.5011 24.4772 -2.0112 13.7552
⏷ Show the Full List of 55 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC1TKB GDSC1; GDSC2 4.615 6.1382 2.8214 1.0451
ETK-1 GDSC1; GDSC2 5.7055 7.9109 2.6133 0.9225
TGBC24TKB GDSC1; GDSC2 5.7966 7.7945 2.6953 0.6008
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MFE-319 GDSC1; GDSC2 4.9887 6.685 2.7758 0.8796
EN GDSC1; GDSC2 4.9959 6.4899 2.855 0.5839
MFE-280 GDSC1; GDSC2 5.2064 7.5751 2.5162 1.7817
RL95-2 GDSC1; GDSC2 5.2149 6.7546 2.8461 0.4773
AN3-CA GDSC1; GDSC2 5.9085 7.8287 2.7271 0.4589
MFE-296 GDSC1; GDSC2 6.3262 7.952 2.8366 0.1325
KLE GDSC1; GDSC2 6.4883 8.6441 2.6561 0.395
ESS-1 GDSC1; GDSC2 6.9969 14.2037 0.5824 8.8346
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCC010 GDSC1; GDSC2 4.0254 6.7576 2.1492 5.6097
A-498 GDSC1; GDSC2 4.8521 6.1775 2.9133 0.4851
KTCTL-13 GDSC1; GDSC2 4.8861 6.7914 2.6838 1.3711
769-P GDSC1; GDSC2 4.8883 7.3719 2.4356 2.5926
SW13 GDSC1; GDSC2 4.9492 6.7798 2.7192 1.1484
KMRC-20 GDSC1; GDSC2 5.0051 7.1789 2.5811 1.7114
RCC10RGB GDSC1; GDSC2 5.1067 6.7974 2.7842 0.7529
786-O GDSC1; GDSC2 5.1262 7.7057 2.4192 2.3475
KTCTL-195 GDSC1; GDSC2 5.1358 7.5659 2.4841 2.0168
A-704 GDSC1; GDSC2 5.1422 7.3713 2.5692 1.6099
LB1047-RCC GDSC1; GDSC2 5.1632 8.1325 2.2527 3.1489
HA7-RCC GDSC1; GDSC2 5.1635 7.7291 2.4288 2.2514
SW156 GDSC1; GDSC2 5.227 9.2956 1.763 5.7192
KTCTL-140 GDSC1; GDSC2 5.3824 7.8639 2.4831 1.737
VMRC-RCW GDSC1; GDSC2 5.3868 7.1041 2.7858 0.561
SN12C GDSC1; GDSC2 5.4608 7.1991 2.7806 0.5346
KTCTL-26A GDSC1; GDSC2 5.4767 7.5787 2.6423 0.9896
LB996-RCC GDSC1; GDSC2 5.5025 10.3407 1.4493 6.9612
LB2241-RCC GDSC1; GDSC2 5.5363 7.808 2.5786 1.1845
BFTC-909 GDSC1; GDSC2 5.5521 7.4401 2.7278 0.6425
KTCTL-21 GDSC1; GDSC2 5.732 10.672 1.4375 6.6163
VMRC-RCZ GDSC1; GDSC2 5.7486 8.0694 2.5706 1.0433
BB65-RCC GDSC1; GDSC2 5.9813 7.7842 2.7708 0.328
TK-10 GDSC1; GDSC2 6.0293 8.2432 2.6228 0.6859
RXF 393L GDSC1; GDSC2 6.1238 11.8454 1.1362 7.5353
OS-RC-2 GDSC1; GDSC2 6.1243 7.586 2.8899 0.1029
ACHN GDSC1; GDSC2 6.165 7.5357 2.9203 0.0687
KTCTL-1M GDSC1; GDSC2 6.2632 8.2821 2.7 0.3804
KMRC-1 GDSC1; GDSC2 6.3388 7.4677 2.9992 0.0155
NCC021 GDSC1; GDSC2 7.2269 21.7469 -2.8472 21.6058
CAL-54 GDSC1; GDSC2 7.3442 15.9551 -0.0113 11.0038
Caki-1 GDSC1; GDSC2 7.7017 14.7094 0.7613 6.9172
UO-31 GDSC1; GDSC2 8.9185 20.4537 -1.1219 12.983
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 48 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H508 GDSC1; GDSC2 3.4947 8.6374 0.8067 15.1229
CCK-81 GDSC1; GDSC2 4.2312 6.1734 2.5638 2.7112
CW-2 GDSC1; GDSC2 4.2773 6.0879 2.6307 2.256
COLO205 GDSC1; GDSC2 4.4323 5.6863 2.9188 0.8064
HT115 GDSC1; GDSC2 4.4806 7.4453 2.1556 4.8659
LS513 GDSC1; GDSC2 4.5485 6.3864 2.6508 1.7428
NCI-H716 GDSC1; GDSC2 4.5701 7.107 2.3408 3.3832
SW1463 GDSC1; GDSC2 4.5878 6.9031 2.4736 2.8509
SNU-C1 GDSC1; GDSC2 4.6182 6.2829 2.7312 1.2628
LS123 GDSC1; GDSC2 4.6689 8.0289 2.0023 5.394
COLO 320HSR GDSC1; GDSC2 4.8104 6.9672 2.5701 2.0105
SW948 GDSC1; GDSC2 4.8306 6.8044 2.6192 1.5411
SNU-283 GDSC2 4.8368 7.585 2.2813 3.2712
HCC2998 GDSC1; GDSC2 4.8692 10.6092 0.8733 11.2224
MDST8 GDSC1; GDSC2 4.8797 6.6476 2.7401 1.1281
C2BBe1 GDSC1; GDSC2 4.8816 7.2007 2.5069 2.2338
T84 GDSC1; GDSC2 4.8828 7.8202 2.2316 3.7009
RKO GDSC1; GDSC2 4.9185 8.6451 1.8441 5.5867
SNU-1040 GDSC1 4.9693 7.1482 2.5758 2.2239
LoVo GDSC1; GDSC2 5.0914 8.7842 1.9158 5.1044
GP5d GDSC1; GDSC2 5.0984 6.9032 2.739 0.9303
HCT 116 GDSC1; GDSC2 5.1107 12.4224 0.189 14.4781
HCT 15 GDSC1; GDSC2 5.2205 7.2474 2.6575 1.1481
SK-CO-1 GDSC1; GDSC2 5.2373 12.9084 0.016 14.8291
LS411N GDSC1; GDSC2 5.2632 6.6943 2.8541 0.3237
SW48 GDSC1; GDSC2 5.2675 10.7335 1.0852 9.1958
LS1034 GDSC1; GDSC2 5.2753 9.9883 1.4705 7.2681
SNU-61 GDSC1; GDSC2 5.331 6.9661 2.8146 0.5061
HT-55 GDSC1; GDSC2 5.3451 7.4381 2.6386 1.113
COLO 678 GDSC1; GDSC2 5.457 7.7299 2.5734 1.2752
KM12 GDSC1; GDSC2 5.4914 8.4499 2.2605 2.4575
LS180 GDSC1; GDSC2 5.5381 7.5435 2.6826 0.7998
SW837 GDSC1; GDSC2 5.5385 7.479 2.7074 0.7164
SNU-81 GDSC1; GDSC2 5.5976 7.4457 2.7443 0.5662
SW626 GDSC1; GDSC2 5.6132 11.2433 1.0975 8.6716
NCI-H747 GDSC1; GDSC2 5.7293 8.3436 2.4211 1.4821
CL-11 GDSC1; GDSC2 5.8986 8.9619 2.2815 2.085
SNU-C2B GDSC1; GDSC2 5.9659 9.2563 2.161 2.37
SW1116 GDSC1; GDSC2 6.0042 7.8714 2.7485 0.3686
SNU-175 GDSC1; GDSC2 6.0151 8.2282 2.6227 0.6944
DiFi GDSC1; GDSC2 6.0159 8.2207 2.5927 0.6646
SW620 GDSC1; GDSC2 6.2595 7.9363 2.8187 0.1681
SNU-407 GDSC1; GDSC2 6.3408 13.6687 0.4244 10.7546
CaR-1 GDSC1; GDSC2 6.7983 16.0029 -0.3801 13.6082
SNU-C5 GDSC1; GDSC2 6.9243 9.1843 2.6273 0.3155
SW1417 GDSC1; GDSC2 7.3618 16.0211 -0.031 11.0618
RCM-1 [Human ESC] GDSC1; GDSC2 8.1629 17.1123 -0.0491 9.8522
HT-29 GDSC1; GDSC2 9.3615 19.2223 -0.3077 9.2047
⏷ Show the Full List of 48 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1; GDSC2 5.4328 7.2156 2.763 0.6045
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-4 GDSC1; GDSC2 3.6101 4.8851 2.7916 2.8907
SNU-449 GDSC1; GDSC2 3.9935 5.3982 2.8048 2.0079
HuH-1 GDSC1; GDSC2 4.3292 6.44 2.53 2.9761
Hep 3B2.1-7 GDSC1; GDSC2 4.7167 8.3507 1.8813 6.0061
JHH-1 GDSC1; GDSC2 4.737 7.5579 2.2641 3.7664
Hep-G2/C3A GDSC1; GDSC2 5.0092 6.5367 2.8428 0.6166
JHH-6 GDSC1; GDSC2 5.1516 6.1686 3.0306 0.0947
SNU-475 GDSC1 5.1757 6.6256 2.8781 0.5075
SNU-387 GDSC1; GDSC2 5.2073 7.2712 2.6418 1.2255
SK-HEP-1 GDSC1; GDSC2 5.3618 6.6451 2.942 0.1855
SNU-423 GDSC1; GDSC2 5.4177 7.2525 2.7427 0.6788
HLE GDSC1; GDSC2 5.4445 7.4104 2.6937 0.8274
JHH-7 GDSC1; GDSC2 5.801 7.4768 2.8122 0.3031
SNU-398 GDSC1; GDSC2 5.8344 7.5714 2.7911 0.3367
Huh-7 GDSC1; GDSC2 6.0562 7.8438 2.7776 0.2893
JHH-2 GDSC1; GDSC2 6.579 8.1647 2.8518 0.0825
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 186 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H847 GDSC1; GDSC2 3.9428 5.6685 2.6448 3.0462
BEN GDSC1; GDSC2 4.0034 5.263 2.8729 1.606
NCI-H146 GDSC1; GDSC2 4.039 6.1389 2.4569 3.709
NCI-H2810 GDSC1; GDSC2 4.292 7.009 2.2107 4.6632
NCI-H1734 GDSC1; GDSC2 4.2974 6.2719 2.5588 2.624
NCI-H1781 GDSC1; GDSC2 4.3087 6.3189 2.5733 2.7664
NCI-H1693 GDSC1; GDSC2 4.3753 7.5209 2.0221 5.6168
SBC-5 GDSC1; GDSC2 4.4844 5.9932 2.8168 1.2142
NCI-H1755 GDSC1; GDSC2 4.5037 7.3471 2.2168 4.4623
NCI-H250 GDSC2 4.5111 6.5423 2.5616 2.2628
NCI-H2869 GDSC1; GDSC2 4.5222 6.8709 2.4492 3.0958
NCI-H510A GDSC1; GDSC2 4.5363 6.4791 2.6339 2.0665
KNS-62 GDSC1; GDSC2 4.5363 6.3271 2.6699 1.6625
NCI-H1341 GDSC1; GDSC2 4.5625 7.5533 2.1292 4.6114
NCI-H720 GDSC1; GDSC2 4.6266 10.2914 0.8819 11.9698
LB647-SCLC GDSC1; GDSC2 4.6455 6.6714 2.5791 1.9755
NCI-H1563 GDSC1; GDSC2 4.6783 6.73 2.602 2.0289
NCI-H2141 GDSC1; GDSC2 4.6784 6.4451 2.7247 1.4198
NCI-H1105 GDSC1; GDSC2 4.679 7.1385 2.3908 2.9252
NCI-H838 GDSC1; GDSC2 4.7086 8.3495 1.8766 6.0496
NCI-H290 GDSC1; GDSC2 4.7221 6.934 2.5364 2.3065
HCC366 GDSC1; GDSC2 4.735 9.9402 1.1037 10.2355
NCI-H835 GDSC1; GDSC2 4.7375 7.945 2.0567 4.7035
NCI-H2029 GDSC1; GDSC2 4.7625 6.3322 2.8127 0.934
VMRC-LCD GDSC1; GDSC2 4.7686 7.8195 2.1339 4.2065
NCI-H345 GDSC1; GDSC2 4.7697 5.7743 3.0289 0.2032
NCI-H2135 GDSC1; GDSC2 4.7851 6.3888 2.8005 0.9639
Lu-165 GDSC1; GDSC2 4.7879 6.2399 2.8613 0.7169
DMS 114 GDSC1; GDSC2 4.7891 6.6612 2.6897 1.454
COR-L279 GDSC1; GDSC2 4.796 6.1831 2.8545 0.5855
NCI-H1304 GDSC1 4.8048 6.8819 2.6039 2.0464
NCI-H211 GDSC1; GDSC2 4.8203 9.183 1.554 7.7012
NCI-H3255 GDSC1; GDSC2 4.8673 8.2429 2.0279 4.8726
NCI-H2444 GDSC1; GDSC2 4.8746 5.9945 2.9901 0.2527
NCI-H1568 GDSC1; GDSC2 4.892 7.2078 2.5095 2.2065
LCLC-103H GDSC1; GDSC2 4.8952 6.1251 2.9505 0.3471
NCI-H2171 GDSC1; GDSC2 4.9026 6.8152 2.6821 1.361
LOU-NH91 GDSC1; GDSC2 4.9241 6.5531 2.7988 0.8445
NCI-H292 GDSC1; GDSC2 4.9393 7.3962 2.453 2.43
NCI-H1963 GDSC1; GDSC2 4.9407 7.0078 2.5892 1.5542
NCI-H2369 GDSC1; GDSC2 4.9485 6.4564 2.8476 0.6431
COR-L95 GDSC1; GDSC2 4.9502 6.6302 2.78 0.8962
NCI-H2803 GDSC1; GDSC2 4.9511 6.9217 2.6618 1.3999
NCI-H2228 GDSC1; GDSC2 4.9512 8.1229 2.1344 4.1253
COR-L88 GDSC1; GDSC2 4.957 6.5696 2.8071 0.7851
NCI-H1915 GDSC1; GDSC2 4.9604 6.3655 2.8874 0.5004
HCC33 GDSC1; GDSC2 4.9619 10.8757 0.836 11.4495
NCI-H1770 GDSC1; GDSC2 4.9801 10.1583 1.1948 9.419
SW1271 GDSC1; GDSC2 4.9802 7.4726 2.4419 2.4298
NCI-H647 GDSC1; GDSC2 4.9874 7.6168 2.3826 2.7257
A-427 GDSC1; GDSC2 4.9876 7.2886 2.5254 2.0014
NCI-H1975 GDSC1; GDSC2 4.9879 6.9684 2.6288 1.323
Calu-6 GDSC1; GDSC2 4.9885 7.0635 2.5897 1.4978
EKVX GDSC1; GDSC2 5.0051 7.1095 2.5788 1.5292
NCI-H187 GDSC1 5.0157 6.0789 3.013 0.1708
RERF-LC-KJ GDSC1; GDSC2 5.036 7.1923 2.5911 1.6288
NCI-H748 GDSC1; GDSC2 5.0437 8.1286 2.1863 3.6872
NCI-H2085 GDSC1; GDSC2 5.0582 7.2192 2.591 1.6043
Lu-135 GDSC1; GDSC2 5.0766 7.4102 2.5198 1.9179
NCI-H1048 GDSC1; GDSC2 5.0839 9.8549 1.4093 7.9897
NCI-H2023 GDSC1; GDSC2 5.0979 6.8948 2.7421 0.9184
NCI-H226 GDSC1; GDSC2 5.1105 6.8338 2.7717 0.7958
COR-L311 GDSC1; GDSC2 5.1278 7.3184 2.5841 1.5581
SBC-1 GDSC1; GDSC2 5.1541 7.0105 2.7216 0.9506
NCI-H64 GDSC1; GDSC2 5.166 7.5079 2.524 1.7917
NCI-H1703 GDSC1; GDSC2 5.1837 7.5927 2.4973 1.8963
EBC-1 GDSC1; GDSC2 5.199 7.7367 2.4441 2.1321
HCC15 GDSC1; GDSC2 5.213 7.141 2.6966 0.9985
NCI-H2066 GDSC1; GDSC2 5.2213 7.1317 2.6716 0.9305
NCI-H841 GDSC1; GDSC2 5.2289 7.2102 2.6763 1.0648
NCI-H1666 GDSC1; GDSC2 5.2625 9.2752 1.765 5.412
IA-LM GDSC1; GDSC2 5.2635 6.6679 2.8971 0.3155
COLO 668 GDSC1; GDSC2 5.2669 11.2981 0.8426 10.7478
NCI-H2196 GDSC1; GDSC2 5.2688 6.6134 2.9187 0.263
LK-2 GDSC1; GDSC2 5.2747 8.5077 2.149 3.5297
NCI-H522 GDSC1; GDSC2 5.2789 7.1561 2.7201 0.8558
HCC44 GDSC1; GDSC2 5.2817 7.8088 2.4559 1.9757
NCI-H2172 GDSC1; GDSC2 5.2818 6.5626 2.9415 0.2104
NCI-H2347 GDSC1; GDSC2 5.2852 7.466 2.5995 1.3283
EPLC-272H GDSC1; GDSC2 5.2909 9.6703 1.6289 6.353
NCI-H2087 GDSC1; GDSC2 5.2939 7.3122 2.6331 1.0186
NCI-H727 GDSC1; GDSC2 5.3046 7.7169 2.5058 1.7193
NCI-H740 GDSC2 5.3103 11.5872 0.706 11.1626
NCI-H1092 GDSC1; GDSC2 5.321 7.3765 2.6522 1.0803
NCI-H1694 GDSC1; GDSC2 5.334 6.672 2.9223 0.2322
NCI-H82 GDSC1; GDSC2 5.3501 6.8857 2.8518 0.3919
NCI-H1688 GDSC1; GDSC2 5.3842 12.7626 0.2171 13.7237
HOP-62 GDSC1; GDSC2 5.3863 6.9824 2.8307 0.4311
NCI-H1437 GDSC1; GDSC2 5.3955 7.2337 2.7405 0.7006
NCI-H2818 GDSC1; GDSC2 5.4149 7.4449 2.6673 0.9451
Lu-139 GDSC1; GDSC2 5.4552 6.8721 2.8969 0.2441
NCI-H2170 GDSC1; GDSC2 5.4566 7.2691 2.7527 0.6225
PC-14 GDSC1; GDSC2 5.4688 10.2511 1.47 6.909
NCI-H2461 GDSC1; GDSC2 5.4791 8.3209 2.3401 2.289
HCC827 GDSC1; GDSC2 5.4895 9.7702 1.7044 5.5844
NCI-H2227 GDSC1; GDSC2 5.5033 7.4166 2.7163 0.71
DMS 53 GDSC1; GDSC2 5.5139 7.6875 2.6161 1.0584
NCI-H1299 GDSC1; GDSC2 5.5162 7.941 2.5159 1.458
NCI-H1573 GDSC1; GDSC2 5.5205 6.9456 2.8951 0.2265
EMC-BAC-2 GDSC1; GDSC2 5.5438 7.5412 2.686 0.7846
A-549 GDSC1; GDSC2 5.5517 8.2826 2.3927 1.9608
SBC-3 GDSC1; GDSC2 5.5579 8.2046 2.4281 1.7953
NCI-H460 GDSC1; GDSC2 5.564 6.7705 2.9706 0.0976
NCI-H2291 GDSC1; GDSC2 5.5827 7.2792 2.7997 0.4202
DMS 79 GDSC1; GDSC2 5.5861 7.1174 2.859 0.2786
COR-L321 GDSC1; GDSC2 5.6005 6.9923 2.908 0.1806
NCI-H2122 GDSC1; GDSC2 5.6085 12.3551 0.5394 11.4079
COR-L303 GDSC1; GDSC2 5.6118 6.9484 2.9271 0.1474
DMS 273 GDSC1; GDSC2 5.613 7.1429 2.86 0.2672
NCI-H23 GDSC1; GDSC2 5.6182 8.5046 2.3331 2.1592
LCLC-97TM1 GDSC1; GDSC2 5.6184 13.6178 -0.0335 14.421
NCI-H810 GDSC1; GDSC2 5.6226 7.4687 2.7459 0.5479
NCI-H1436 GDSC1; GDSC2 5.6257 6.8456 2.9667 0.0924
Lu-99A GDSC1; GDSC2 5.6297 7.6585 2.6776 0.7554
LXF 289 GDSC1; GDSC2 5.639 8.4943 2.3478 2.0683
SK-LU-1 GDSC1 5.641 8.208 2.4665 1.7102
NCI-H1648 GDSC1; GDSC2 5.6442 19.1781 -2.7638 24.3994
Lu-65 GDSC1; GDSC2 5.6534 7.3766 2.7919 0.4083
HARA [Human squamous cell lung carcinoma] GDSC1; GDSC2 5.6746 10.1834 1.6265 5.6947
NCI-H358 GDSC1; GDSC2 5.6791 8.2614 2.4628 1.5247
NCI-H69 GDSC1; GDSC2 5.6799 7.6137 2.7153 0.6065
RERF-LC-MS GDSC1; GDSC2 5.6983 7.4821 2.771 0.4413
NCI-H441 GDSC1; GDSC2 5.7067 7.2163 2.8688 0.2209
NCI-H524 GDSC1; GDSC2 5.7112 7.5974 2.7339 0.5355
ABC-1 GDSC1; GDSC2 5.7212 7.6151 2.7314 0.5375
NCI-H3122 GDSC1; GDSC2 5.7279 7.8917 2.6302 0.8484
NCI-H2110 GDSC1; GDSC2 5.7446 7.6764 2.7182 0.5627
ChaGo-K-1 GDSC1; GDSC2 5.7456 7.5803 2.7538 0.4643
COR-L32 GDSC2 5.7556 7.8431 2.6274 0.7088
NCI-H209 GDSC1; GDSC2 5.7626 7.6918 2.7197 0.549
PaCa-3 GDSC1; GDSC2 5.7764 8.3114 2.4877 1.3355
NCI-H2009 GDSC1; GDSC2 5.8063 8.159 2.561 1.0346
NCI-H322M GDSC1; GDSC2 5.8201 8.0775 2.5984 0.8936
NCI-H2795 GDSC1; GDSC2 5.8241 7.8616 2.6816 0.6261
NCI-H650 GDSC1; GDSC2 5.838 8.0058 2.6332 0.7668
NCI-H526 GDSC1; GDSC2 5.8412 7.4145 2.8488 0.2193
NCI-H2722 GDSC1; GDSC2 5.8431 11.4623 1.1406 8.0103
NCI-H2595 GDSC1; GDSC2 5.8491 7.742 2.7355 0.4643
NCI-H1993 GDSC1; GDSC2 5.8525 8.3233 2.5172 1.1594
NCI-H2081 GDSC1; GDSC2 5.857 7.4665 2.8364 0.2372
NCI-H1435 GDSC1; GDSC2 5.8921 7.3658 2.8837 0.1512
UMC-11 GDSC1; GDSC2 5.8976 7.6404 2.7904 0.3157
IST-SL1 GDSC1; GDSC2 5.9128 7.6491 2.793 0.3049
NCI-H2591 GDSC1; GDSC2 5.9208 8.5417 2.4619 1.3138
NCI-H2405 GDSC1; GDSC2 5.9221 8.6683 2.4121 1.5088
NCI-H2373 GDSC1; GDSC2 5.9494 7.7442 2.7731 0.3346
IST-SL2 GDSC1; GDSC2 5.9595 8.8608 2.352 1.7205
NCI-H1793 GDSC1; GDSC2 5.9757 7.6104 2.8295 0.2169
NCI-H2804 GDSC1; GDSC2 5.9925 10.8195 1.5253 5.7142
NCI-H661 GDSC1; GDSC2 6.0219 7.7367 2.8025 0.2523
NCI-H1876 GDSC1; GDSC2 6.0306 8.3965 2.5658 0.8628
SHP-77 GDSC1; GDSC2 6.032 12.4244 0.8108 9.3904
NCI-H1838 GDSC1; GDSC2 6.0327 7.9235 2.7407 0.3753
HCC78 GDSC1; GDSC2 6.0354 7.9505 2.7321 0.394
NCI-H2342 GDSC1; GDSC2 6.0898 7.9811 2.7417 0.3521
NCI-H196 GDSC1; GDSC2 6.1249 7.483 2.9242 0.0697
NCI-H1155 GDSC1; GDSC2 6.1371 7.6519 2.8722 0.121
CPC-N GDSC1; GDSC2 6.1483 7.9423 2.7769 0.263
NCI-H1836 GDSC1; GDSC2 6.1594 7.5971 2.8981 0.0896
NCI-H1623 GDSC1; GDSC2 6.1639 8.3917 2.6221 0.6167
NCI-H1944 GDSC1; GDSC2 6.1815 10.3125 1.8547 3.7569
NCI-H1650 GDSC1; GDSC2 6.2425 8.0417 2.7766 0.2377
NCI-H1581 GDSC1; GDSC2 6.2504 7.8154 2.8563 0.1214
LC-2/ad GDSC1; GDSC2 6.293 8.4609 2.6474 0.4904
NCI-H520 GDSC1; GDSC2 6.3009 12.8666 0.7735 9.0889
HOP-92 GDSC1; GDSC2 6.3349 8.7416 2.5614 0.699
NCI-H1355 GDSC1; GDSC2 6.3411 8.4513 2.6692 0.4199
NCI-H1792 GDSC1; GDSC2 6.4368 8.3107 2.7536 0.2272
NCI-H513 GDSC1; GDSC2 6.4652 11.5086 1.4865 5.1944
RERF-LC-Sq1 GDSC1; GDSC2 6.6534 13.3936 0.7465 8.6099
NCI-H1869 GDSC1 6.6713 8.265 2.8497 0.0827
NCI-H1651 GDSC1; GDSC2 6.715 13.9161 0.5436 9.4983
Lu-134-A GDSC1; GDSC2 6.7455 8.8799 2.6681 0.2921
SW1573 GDSC1; GDSC2 6.8065 8.9605 2.6622 0.2861
CAL-12T GDSC1; GDSC2 6.8094 19.0807 -1.8474 19.2649
LC-1/sq GDSC1; GDSC2 7.0191 9.3047 2.6199 0.303
EMC-BAC-1 GDSC1; GDSC2 7.9497 16.179 0.2475 8.8809
NCI-H2731 GDSC1; GDSC2 8.1597 18.5849 -0.7247 12.6562
SK-MES-1 GDSC1; GDSC2 8.3558 17.7533 -0.226 10.3084
NCI-H2030 GDSC1; GDSC2 8.4026 17.4482 -0.0612 9.5446
NCI-H446 GDSC1; GDSC2 8.4148 17.9051 -0.2601 10.3614
Ms-1 GDSC1; GDSC2 8.5222 18.0853 -0.2787 10.277
Calu-3 GDSC1; GDSC2 8.9067 19.7329 -0.7993 11.7799
NCI-H596 GDSC1; GDSC2 9.5287 21.5673 -1.2646 12.593
COR-L23 GDSC1; GDSC2 9.8206 22.152 -1.3574 12.5047
COR-L105 GDSC1; GDSC2 10.4692 21.3755 -0.6438 9.0663
⏷ Show the Full List of 186 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1; GDSC2 4.9049 6.6943 2.733 1.1334
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OE19 GDSC1; GDSC2 4.5254 7.5998 2.1117 5.0351
EC-GI-10 GDSC1; GDSC2 4.8952 6.6266 2.7559 1.0453
KYSE-70 GDSC1; GDSC2 4.9355 8.3633 2.0144 4.8262
TE-9 GDSC1; GDSC2 4.9802 6.434 2.8697 0.5454
TE-10 GDSC1; GDSC2 5.0361 6.8013 2.7511 0.936
TE-6 GDSC1; GDSC2 5.1778 9.7183 1.5349 7.0937
T.T GDSC1; GDSC2 5.2235 11.0714 0.922 10.4106
TE-11 GDSC1; GDSC2 5.2297 16.6648 -1.8086 22.4844
KYSE-140 GDSC1; GDSC2 5.3226 9.5288 1.714 5.8217
KYSE-270 GDSC1; GDSC2 5.4849 8.3344 2.3374 2.2951
KYSE-520 GDSC1; GDSC2 5.5551 8.7871 2.1803 2.9727
COLO 680N GDSC1; GDSC2 5.8442 7.3897 2.8584 0.2017
KYSE-180 GDSC1; GDSC2 5.9041 7.5897 2.8107 0.2722
TE-5 GDSC1; GDSC2 5.9924 7.5639 2.8515 0.1772
TE-4 GDSC1; GDSC2 6.3037 7.716 2.9074 0.0652
KYSE-510 GDSC1; GDSC2 6.3347 7.7105 2.9195 0.0536
OE33 GDSC1; GDSC2 6.4259 12.8413 0.8621 8.4208
OE21 GDSC1; GDSC2 6.6133 12.2401 1.2452 6.1843
TE-8 GDSC1; GDSC2 6.6137 15.2575 -0.1479 12.9305
TE-15 GDSC1; GDSC2 6.8024 13.8989 0.6048 9.0514
KYSE-410 GDSC1; GDSC2 6.9393 8.7015 2.7956 0.0915
KYSE-450 GDSC1; GDSC2 7.0304 12.6508 1.2957 5.3354
KYSE-150 GDSC1; GDSC2 8.5841 19.9119 -1.0767 13.3366
TE-1 GDSC1; GDSC2 9.5363 19.4272 -0.301 8.9465
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHOS-2 GDSC1; GDSC2 4.528 6.5421 2.6013 2.2522
OV56 GDSC1; GDSC2 4.8722 6.2279 2.9026 0.5072
OV-90 GDSC1; GDSC2 4.8766 6.4899 2.8023 0.8721
OAW42 GDSC1 4.9259 6.0151 3.0022 0.2266
DOV13 GDSC1; GDSC2 4.9461 6.7215 2.7415 1.0574
Caov-3 GDSC1; GDSC2 4.9884 6.3113 2.9191 0.3874
Caov-4 GDSC1; GDSC2 5.0028 7.4875 2.4476 2.3696
ES-2 GDSC1; GDSC2 5.1862 6.73 2.8436 0.5012
EFO-21 GDSC1; GDSC2 5.2617 8.6842 2.0627 4.0103
EFO-27 GDSC1; GDSC2 5.2643 7.6868 2.4984 1.7982
OVK18 GDSC1; GDSC2 5.3615 6.8091 2.884 0.3067
OVCAR-3 GDSC1; GDSC2 5.4266 7.0348 2.8275 0.4202
TOV-112D GDSC1; GDSC2 5.4284 7.426 2.6806 0.886
OC 314 GDSC1; GDSC2 5.4609 8.7691 2.1371 3.3201
FU-OV-1 GDSC1; GDSC2 5.4755 10.2939 1.4543 6.9833
OVCAR-5 GDSC1; GDSC2 5.6277 8.2314 2.4507 1.6255
TYK-nu GDSC1; GDSC2 5.7308 7.5572 2.7564 0.4644
IGROV-1 GDSC1; GDSC2 5.8543 8.3377 2.5124 1.176
OVCAR-4 GDSC1; GDSC2 5.8619 9.5593 2.0099 3.4131
SK-OV-3 GDSC1; GDSC2 5.8939 7.6854 2.773 0.3549
RMG-I GDSC1; GDSC2 5.9144 11.343 1.2398 7.3549
OVCAR-8 GDSC1; GDSC2 6.0593 12.857 0.6253 10.2868
OVKATE GDSC1; GDSC2 6.0849 8.7521 2.4523 1.2185
TOV-21G GDSC1; GDSC2 6.5938 13.2744 0.7651 8.6189
JHOS-4 GDSC1; GDSC2 6.6993 18.5071 -1.6735 18.7287
OVTOKO GDSC1; GDSC2 6.9857 13.8123 0.7537 8.0277
Kuramochi GDSC1; GDSC2 9.2594 18.6195 -0.0986 8.504
A2780 GDSC1; GDSC2 9.9804 21.8056 -1.1078 11.3931
OVISE GDSC1; GDSC2 10.2924 20.9431 -0.5511 8.941
OAW28 GDSC1; GDSC2 10.5113 20.9766 -0.448 8.2925
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DAN-G GDSC1; GDSC2 4.5613 6.3316 2.7121 1.6289
KP-2 GDSC1; GDSC2 4.612 6.1674 2.8078 1.1095
KP-1N GDSC1; GDSC2 4.682 6.7734 2.5545 2.0513
Panc 04.03 GDSC1; GDSC2 4.824 6.6702 2.7035 1.3502
PaTu 8902 GDSC1; GDSC2 4.832 6.4633 2.7923 0.9532
SU.86.86 GDSC1; GDSC2 4.8724 6.3024 2.8741 0.6045
CFPAC-1 GDSC1; GDSC2 4.8807 8.4225 1.9528 5.277
Panc 10.05 GDSC1; GDSC2 5.0185 9.1456 1.7018 6.4526
Hs 766T GDSC1; GDSC2 5.1114 7.1651 2.6394 1.33
HuP-T3 GDSC1; GDSC2 5.1175 8.3106 2.1472 3.7818
MIA PaCa-2 GDSC1; GDSC2 5.1512 7.311 2.5987 1.4675
SUIT-2 GDSC1; GDSC2 5.3187 7.6893 2.5242 1.6216
PL4 GDSC1; GDSC2 5.3505 7.2762 2.7048 0.8571
KP-4 GDSC1; GDSC2 5.3535 6.8043 2.8826 0.3131
YAPC GDSC1; GDSC2 5.4333 7.2952 2.733 0.7006
PSN1 GDSC1; GDSC2 5.4925 7.4451 2.7009 0.7688
QGP-1 GDSC1; GDSC2 5.5122 8.3291 2.3535 2.1867
Panc 02.03 GDSC1; GDSC2 5.762 7.8297 2.668 0.7032
MZ-PC-1 GDSC1; GDSC2 5.7854 9.4802 2.0031 3.5505
HPAF-II GDSC1 5.7866 8.8777 2.2612 2.5428
PaTu 8988t GDSC1; GDSC2 5.8705 6.986 3.0024 0.0357
KP-3 GDSC1; GDSC2 5.8865 8.5353 2.4489 1.3935
BxPC-3 GDSC1; GDSC2 6.2185 8.5396 2.5894 0.6806
SW1990 GDSC1; GDSC2 6.2399 7.863 2.8367 0.1474
Panc 03.27 GDSC1; GDSC2 6.5857 14.4954 0.193 11.4104
AsPC-1 GDSC1; GDSC2 6.8773 9.2776 2.5774 0.4266
Panc 08.13 GDSC1; GDSC2 7.2372 16.6628 -0.4078 12.9224
Capan-1 GDSC1; GDSC2 9.3785 21.0588 -1.1224 12.2961
Capan-2 GDSC1; GDSC2 9.3791 18.8295 -0.1251 8.4536
HPAC GDSC1; GDSC2 10.2297 27.4852 -3.5739 18.6948
HuP-T4 GDSC1; GDSC2 10.5705 25.331 -2.3598 14.7548
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IST-Mes1 GDSC1; GDSC2 4.9418 7.1411 2.5646 1.8677
MPP 89 GDSC1; GDSC2 5.0017 6.8885 2.7 1.1789
NCI-H2452 GDSC1; GDSC2 5.3265 10.041 1.4784 7.1268
NCI-H2052 GDSC1; GDSC2 5.7517 11.5837 1.0263 8.7887
MSTO-211H GDSC1; GDSC2 5.7584 7.4752 2.7967 0.353
NCI-H28 GDSC1; GDSC2 8.0698 17.5459 -0.3015 11.069
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VCaP GDSC1; GDSC2 4.836 7.0474 2.5491 2.0821
LNCaP clone FGC GDSC1; GDSC2 5.024 6.9382 2.6903 1.1982
NCI-H660 GDSC2 5.0843 6.7495 2.7605 0.7091
PC-3 GDSC1; GDSC2 6.0421 8.5378 2.5167 1.0201
DU145 GDSC1; GDSC2 6.116 7.909 2.7768 0.2727
22Rv1 GDSC1; GDSC2 10.4397 21.2915 -0.6231 9.0265
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1; GDSC2 5.0971 7.5719 2.4614 2.1763
Cancer Drug Sensitivity Data Curated from 57 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-388 GDSC1; GDSC2 3.4301 7.8776 1.1568 13.5255
SK-MEL-28 GDSC1; GDSC2 3.9847 4.8939 3.0263 0.8192
LB2518-MEL GDSC1; GDSC2 4.09 5.3617 2.8788 1.4352
SK-MEL-5 GDSC1; GDSC2 4.2854 6.2953 2.5698 2.8271
VMRC-MELG GDSC1; GDSC2 4.3661 6.9586 2.311 4.1768
A-375 GDSC1; GDSC2 4.3732 6.1153 2.7036 1.9405
SK-MEL-31 GDSC1; GDSC2 4.7129 10.199 0.9624 11.084
A101D GDSC1; GDSC2 4.7319 7.0465 2.4922 2.5253
GAK GDSC1; GDSC2 4.757 7.5323 2.2878 3.5996
A2058 GDSC1; GDSC2 4.7708 6.0541 2.926 0.4964
Hs 940.T GDSC1; GDSC2 4.7802 8.7232 1.7465 6.6651
451Lu GDSC1; GDSC2 4.8644 7.1051 2.5393 2.0934
COLO 800 GDSC1; GDSC2 4.8671 6.7397 2.696 1.3369
SK-MEL-2 GDSC1; GDSC2 4.909 6.0374 2.9878 0.2438
HT-144 GDSC1; GDSC2 4.9295 6.4053 2.8591 0.6162
SK-MEL-3 GDSC1; GDSC2 5.0695 10.1828 1.2436 8.9554
Hs 938.T GDSC1; GDSC2 5.0917 7.7555 2.379 2.5968
SK-MEL-1 GDSC1; GDSC2 5.1056 6.2763 2.977 0.1961
SK-MEL-30 GDSC1; GDSC2 5.1455 8.529 2.065 4.1847
RPMI-7951 GDSC1; GDSC2 5.1906 6.7909 2.8226 0.5643
WT2-iPS GDSC1; GDSC2 5.2018 7.3416 2.6106 1.3635
A-431 GDSC1; GDSC2 5.2161 10.8332 1.0311 9.8303
HMV-II GDSC1; GDSC2 5.271 7.6001 2.5377 1.6121
CP66-MEL GDSC1; GDSC2 5.2806 7.3613 2.6397 1.166
SH-4 GDSC1; GDSC2 5.29 8.1915 2.2964 2.7453
CP50-MEL-B GDSC1; GDSC2 5.2957 6.728 2.8879 0.3245
LOX-IMVI GDSC1; GDSC2 5.3242 7.063 2.7754 0.6322
MZ-MEL-7 GDSC1; GDSC2 5.336 7.2419 2.7117 0.8429
WM793 GDSC1; GDSC2 5.3445 7.8807 2.4573 1.8968
DJM-1 GDSC1; GDSC2 5.4091 7.5469 2.6245 1.1134
G-mel GDSC1; GDSC2 5.449 7.1748 2.7848 0.5287
COLO 783 GDSC1; GDSC2 5.4594 6.7536 2.9397 0.1634
RVH-421 GDSC1; GDSC2 5.5313 10.2431 1.5124 6.5624
IGR-37 GDSC1; GDSC2 5.6141 7.0003 2.9101 0.1737
MMAc-SF GDSC1; GDSC2 5.6167 7.2957 2.8069 0.3868
M14 GDSC1 5.668 7.6 2.7155 0.6779
Mel JuSo GDSC1; GDSC2 5.6888 12.756 0.4293 12.0142
COLO 679 GDSC1; GDSC2 5.7255 7.8261 2.6542 0.7702
COLO 792 GDSC1; GDSC2 5.7492 7.724 2.7023 0.6062
WM278 GDSC1; GDSC2 5.7553 12.8419 0.433 11.8587
G-361 GDSC1; GDSC2 5.8162 8.0205 2.6185 0.8287
IPC-298 GDSC1; GDSC2 5.8171 7.1587 2.9275 0.1075
WM1552C GDSC1; GDSC2 5.8472 8.4733 2.4556 1.4011
MZ-MEL-2 GDSC1; GDSC2 5.8648 10.8919 1.4169 6.4984
IGR-1 GDSC1; GDSC2 5.8835 7.8451 2.7114 0.5115
CHL-1 GDSC1; GDSC2 6.1741 7.6707 2.8786 0.1079
SK-MEL-24 GDSC1; GDSC2 6.1887 8.3635 2.6422 0.5504
IST-MEL1 GDSC1; GDSC2 6.2114 10.3532 1.8529 3.7262
WM35 GDSC1; GDSC2 6.5092 13.9632 0.3935 10.5933
COLO 829 GDSC1; GDSC2 6.8834 15.1254 0.087 11.3618
MeWo GDSC1; GDSC2 7.3466 12.5146 1.5195 3.8978
LB373-MEL-D GDSC1; GDSC2 7.4025 15.2293 0.3566 9.2368
WM115 GDSC1; GDSC2 7.4743 15.3538 0.3426 9.1864
Mel Ho GDSC1; GDSC2 7.5782 17.8758 -0.759 13.776
UACC-62 GDSC1; GDSC2 8.201 19.4306 -1.0916 14.0146
UACC-257 GDSC1; GDSC2 10.239 25.1498 -2.4786 15.584
EquiPSC Line K2 GDSC1; GDSC2 6.6617 8.7512 2.6824 0.2897
⏷ Show the Full List of 57 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1; GDSC2 4.6778 6.386 2.7493 1.3046
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYM-1 GDSC1; GDSC2 4.3591 5.77 2.847 1.2227
TE 441.T GDSC1; GDSC2 4.7842 6.3971 2.7967 0.9807
GCT GDSC1; GDSC2 5.0205 6.6882 2.7888 0.8031
SW684 GDSC1; GDSC2 5.0562 7.001 2.6801 1.2101
RKN GDSC1; GDSC2 5.094 8.52 2.0385 4.4159
MES-SA GDSC1; GDSC2 5.2318 6.4353 2.9676 0.1756
HT-1080 GDSC1; GDSC2 5.3448 7.1598 2.7472 0.7123
STS-0421 GDSC1; GDSC2 5.4013 11.5143 0.8022 10.4591
A-204 GDSC1; GDSC2 5.4879 9.3238 1.9059 4.4956
VA-ES-BJ GDSC1; GDSC2 5.4984 6.9667 2.8796 0.2654
EW-8 GDSC1; GDSC2 5.5083 7.0637 2.8487 0.3307
Hs 633.T GDSC1; GDSC2 5.616 11.9997 0.7416 10.5595
SW872 GDSC1; GDSC2 5.6988 7.4439 2.7851 0.4053
G-401 GDSC1; GDSC2 5.7827 8.6423 2.3569 1.8742
SK-UT-1 GDSC1; GDSC2 6.0146 7.6821 2.8187 0.2252
Rh41 GDSC1; GDSC2 6.1654 7.6944 2.8677 0.1218
MFH-ino GDSC1; GDSC2 6.2775 7.7638 2.8828 0.0895
Rh30 GDSC1; GDSC2 6.4177 7.842 2.904 0.0574
RD GDSC1; GDSC2 6.4395 8.7654 2.594 0.56
SK-LMS-1 GDSC1; GDSC2 6.7821 8.4264 2.8336 0.0765
G-402 GDSC1; GDSC2 6.9506 13.1855 1.0152 6.8098
Rh18 GDSC1; GDSC2 8.201 17.6157 -0.2845 10.6206
SW982 GDSC1; GDSC2 8.3121 15.8776 0.5838 6.8816
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ECC12 GDSC2 3.9138 8.0448 1.4338 10.2719
MKN45 GDSC1; GDSC2 4.5506 5.6389 2.9911 0.4255
MKN1 GDSC1; GDSC2 4.6274 6.4313 2.7041 1.5826
HGC-27 GDSC1; GDSC2 4.7316 7.1044 2.4662 2.6641
AGS GDSC1; GDSC2 4.9194 6.9826 2.6204 1.6274
SNU-5 GDSC1; GDSC2 4.9298 6.5585 2.7992 0.8382
SNU-16 GDSC1; GDSC2 4.9859 6.3688 2.8967 0.4555
IM95 GDSC1; GDSC2 5.18 8.0994 2.2767 2.9994
MKN7 GDSC1; GDSC2 5.2936 8.8206 2.0198 4.1912
OCUM-1 GDSC1; GDSC2 5.2982 7.6367 2.5359 1.591
MKN28 GDSC1; GDSC2 5.3397 7.3716 2.6626 1.0238
NCI-N87 GDSC1; GDSC2 5.3552 7.125 2.7648 0.6467
HSC-39 GDSC1; GDSC2 5.3732 7.4279 2.6554 1.0236
23132/87 GDSC1; GDSC2 5.3997 7.358 2.6945 0.8574
NUGC-3 GDSC1; GDSC2 5.4177 7.8535 2.5046 1.6044
NUGC-4 GDSC1; GDSC2 5.4198 7.3501 2.7062 0.801
SNU-1 GDSC1; GDSC2 5.6036 8.0525 2.5118 1.3928
TGBC11TKB GDSC1; GDSC2 5.6666 7.5434 2.736 0.5529
SCH GDSC1; GDSC2 5.7799 13.4827 0.1427 13.237
Fu97 GDSC1; GDSC2 5.7811 9.3931 2.0386 3.3782
TMK-1 GDSC1; GDSC2 6.1702 7.654 2.8828 0.1039
SK-GT-2 GDSC1; GDSC2 6.2153 8.4606 2.5839 0.5871
RF-48 GDSC1; GDSC2 6.2655 7.8301 2.8566 0.1187
KATO III GDSC1; GDSC2 6.4215 14.429 0.0903 12.0083
RERF-GC-1B GDSC1; GDSC2 6.509 12.3533 1.1342 6.9055
GCIY GDSC1; GDSC2 6.8186 14.7762 0.2091 10.9113
Hs 746.T GDSC1; GDSC2 6.8743 13.5244 0.8185 7.8907
ECC10 GDSC1; GDSC2 7.4088 15.6526 0.1672 10.0925
SNG-M GDSC1; GDSC2 4.7025 7.3513 2.3378 3.4128
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IHH-4 GDSC1; GDSC2 4.8399 6.3353 2.847 0.7288
ASH-3 GDSC1; GDSC2 5.042 6.4126 2.9032 0.4047
KMH-2 GDSC1; GDSC2 5.0523 8.0697 2.2178 3.5031
HTC-C3 GDSC1; GDSC2 5.1203 8.2294 2.1853 3.5719
CGTH-W-1 GDSC1; GDSC2 5.1809 9.0535 1.8464 5.3349
K5 GDSC1; GDSC2 5.2808 7.1242 2.7333 0.8063
B-CPAP GDSC1; GDSC2 5.3296 6.8685 2.8501 0.4065
TT GDSC1; GDSC2 5.4096 6.6877 2.9445 0.168
ML-1 [Human leukemia] GDSC1; GDSC2 5.4566 7.5289 2.6529 0.966
CAL-62 GDSC1; GDSC2 5.6001 7.7455 2.6315 0.9346
WRO GDSC1; GDSC2 5.6016 7.8284 2.5999 1.0492
8505C GDSC1; GDSC2 5.6233 7.6745 2.6688 0.7889
TT2609-C02 GDSC1; GDSC2 5.6761 7.2872 2.8326 0.3035
BHT-101 GDSC1; GDSC2 7.3595 16.1761 -0.1041 11.3896
FTC-133 GDSC1; GDSC2 7.9626 16.867 -0.0559 10.1911
8305C GDSC1; GDSC2 10.0377 22.7375 -1.4949 12.6788
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 41 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PCI-15A GDSC1; GDSC2 4.2353 5.949 2.6985 2.1886
JHU-011 GDSC1; GDSC2 4.758 8.2494 1.9559 5.4914
LB771-HNC GDSC1; GDSC2 4.7957 6.9143 2.5851 1.9546
DOK GDSC1; GDSC2 4.831 11.4893 0.4436 13.8403
HSC-4 GDSC1; GDSC2 4.8483 6.4272 2.8144 0.8489
BICR 22 GDSC1; GDSC2 4.9529 6.6805 2.7612 0.9694
Detroit 562 GDSC1; GDSC2 4.9564 10.458 1.0342 10.3698
JHU-029 GDSC1; GDSC2 4.9635 7.4549 2.4099 2.4024
BB49-HNC GDSC1 5.0493 14.6336 -0.9413 21.0395
HO-1-N-1 GDSC1; GDSC2 5.1598 6.9625 2.7432 0.8635
JHU-022 GDSC1; GDSC2 5.1617 7.4852 2.5314 1.7621
HSC-3 GDSC1; GDSC2 5.1876 6.6141 2.8871 0.3755
SCC-4 GDSC1; GDSC2 5.2624 10.1863 1.3691 7.8608
FaDu GDSC1; GDSC2 5.335 6.6758 2.9214 0.2338
KON GDSC1; GDSC2 5.4616 7.1626 2.7945 0.494
BICR 78 GDSC1; GDSC2 5.4758 10.4649 1.3748 7.4205
BHY GDSC1; GDSC2 5.528 8.2334 2.4015 1.9471
BICR 31 GDSC1; GDSC2 5.5508 7.3606 2.757 0.5546
OSC-20 GDSC1; GDSC2 5.5769 7.0739 2.8709 0.2568
Ca9-22 GDSC1; GDSC2 5.5827 10.9377 1.2214 8.0586
BICR 10 GDSC1 5.741 7.3037 2.8509 0.2705
OSC-19 GDSC1; GDSC2 5.741 7.202 2.8861 0.1816
SAS GDSC1; GDSC2 5.7539 10.1457 1.6902 5.2244
PCI-38 GDSC1 5.7596 8.4604 2.4201 1.7995
SCC-25 GDSC1; GDSC2 5.803 11.4956 1.1 8.3004
HO-1-u-1 GDSC1; GDSC2 5.8974 7.8893 2.7007 0.5335
BB30-HNC GDSC1; GDSC2 5.9439 12.6766 0.6358 10.4555
CAL-33 GDSC1; GDSC2 5.9457 7.7247 2.7786 0.324
PCI-04B GDSC1; GDSC2 5.991 8.7518 2.4103 1.4552
SKN-3 GDSC1; GDSC2 5.9914 8.0698 2.6718 0.5661
KOSC-2 GDSC1; GDSC2 6.0083 11.3499 1.2937 6.9077
HSC-2 GDSC1; GDSC2 6.0134 12.4917 0.7675 9.6482
UPCI-SCC-090 GDSC1; GDSC2 6.0321 14.0768 0.0009 13.1952
SAT [Human HNSCC] GDSC1; GDSC2 6.0335 11.6301 1.1803 7.461
NCI-H3118 GDSC1; GDSC2 6.0681 8.1549 2.6709 0.5313
SCC-15 GDSC1; GDSC2 6.1827 13.8566 0.2334 11.9848
PE/CA-PJ15 GDSC1; GDSC2 6.2479 7.6829 2.8996 0.0775
CAL-27 GDSC1; GDSC2 6.4169 13.3497 0.6215 9.6428
SCC-9 GDSC1; GDSC2 6.5425 14.4568 0.1835 11.5354
PCI-30 GDSC1; GDSC2 6.5563 8.0791 2.8723 0.0681
PCI-06A GDSC1; GDSC2 6.5642 12.891 0.9227 7.8814
⏷ Show the Full List of 41 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RT-4 GDSC1; GDSC2 4.2471 13.7831 -1.1347 22.4643
BFTC-905 GDSC1; GDSC2 4.315 7.6162 1.9626 6.3624
HT-1376 GDSC1; GDSC2 4.5957 7.1457 2.3677 3.4278
639V GDSC1; GDSC2 4.8357 5.946 2.9925 0.2634
KU-19-19 GDSC1; GDSC2 4.8559 6.4741 2.7991 0.9033
647V GDSC1; GDSC2 5.1072 6.6113 2.8556 0.5107
HT-1197 GDSC1; GDSC2 5.3309 11.1328 0.9649 9.9526
J82 GDSC1; GDSC2 5.384 7.6506 2.5713 1.3522
TCCSUP GDSC1; GDSC2 5.477 6.9853 2.8649 0.3056
SW780 GDSC1; GDSC2 5.5935 7.1478 2.851 0.2931
T24 GDSC1; GDSC2 5.634 8.9536 2.1503 3.0176
CAL-29 GDSC1; GDSC2 5.8455 7.215 2.9184 0.1138
UM-UC-3 GDSC1; GDSC2 6.31 7.8772 2.8561 0.1125
SW1710 GDSC1; GDSC2 6.4752 8.2454 2.7894 0.1661
5637 GDSC1; GDSC2 6.5429 8.3591 2.7745 0.1732
RT-112 GDSC1; GDSC2 9.1517 19.3917 -0.502 10.2625
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa GDSC1; GDSC2 4.4105 5.9575 2.7934 1.4216
OMC-1 [Human cervical carcinoma] GDSC1; GDSC2 4.7399 6.5746 2.7013 1.4573
C-33 A GDSC1; GDSC2 4.8884 7.1889 2.5158 2.1795
CAL-39 GDSC1; GDSC2 4.9276 7.7343 2.2965 3.2734
PWR-1E GDSC1; GDSC2 5.0664 7.2889 2.5345 1.6647
HEC-1 GDSC1; GDSC2 5.1562 6.7399 2.8275 0.57
SKG-IIIa GDSC1; GDSC2 5.1846 7.0559 2.7175 0.9412
NCC-IT GDSC1; GDSC2 5.2718 6.9537 2.7949 0.6024
JAR GDSC1; GDSC2 5.2736 6.9325 2.8036 0.5734
SW962 GDSC1; GDSC2 5.3058 9.6749 1.636 6.2859
OVCA420 GDSC1; GDSC2 5.3557 8.0966 2.3719 2.2873
NEC8 GDSC1; GDSC2 5.526 7.0584 2.8574 0.304
ACC-OV7 GDSC1; GDSC2 5.5436 9.0034 2.0797 3.4981
SiHa GDSC1; GDSC2 5.5842 7.4752 2.7279 0.6232
DoTc2 4510 GDSC1; GDSC2 5.5926 7.4065 2.7569 0.5323
C-4-I GDSC1; GDSC2 5.6273 7.1642 2.8578 0.267
TC-YIK GDSC1; GDSC2 5.6338 9.1333 2.0416 3.3561
NT2-D1 GDSC1; GDSC2 5.6679 7.2608 2.8388 0.2929
MS751 GDSC1; GDSC2 5.6987 7.3831 2.8069 0.3528
DSH1 GDSC1; GDSC2 5.7564 11.7969 0.9292 9.295
SW756 GDSC1; GDSC2 5.8206 7.4042 2.8449 0.2321
PA-1 GDSC1; GDSC2 5.8771 7.5013 2.8317 0.2402
HEY GDSC1; GDSC2 5.9215 8.4457 2.4998 1.1699
HT-3 GDSC1; GDSC2 5.9365 8.2684 2.5749 0.8943
JHOS-3 GDSC1; GDSC2 6.0085 7.981 2.7108 0.456
LB831-BLC GDSC1; GDSC2 6.0463 7.8423 2.7745 0.2987
SiSo GDSC1; GDSC2 6.1253 8.1245 2.704 0.4238
SKN GDSC1; GDSC2 6.2793 8.3348 2.6874 0.4024
Ca Ski GDSC1; GDSC2 6.2983 12.104 1.1229 7.3079
OV17R GDSC1; GDSC2 6.3655 9.0442 2.4605 0.9912
UWB1.289 GDSC1; GDSC2 6.647 8.8072 2.6575 0.3399
OVCA433 GDSC1; GDSC2 6.7425 13.4567 0.7712 8.3385
OVMIU GDSC1; GDSC2 6.9041 13.7558 0.7312 8.2684
PEO1 GDSC1; GDSC2 7.0107 9.0168 2.715 0.1653
ME-180 GDSC1; GDSC2 7.2615 15.6312 0.0874 10.7001
JEG-3 GDSC1; GDSC2 7.2768 15.8301 0.0049 11.0458
BPH-1 GDSC1; GDSC2 7.3521 17.1675 -0.5711 13.4058
KGN GDSC1; GDSC2 8.0187 20.6992 -1.8054 16.8984
SW954 GDSC1; GDSC2 8.1251 21.4661 -2.0993 17.6974
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6489).
2 Safety and tolerability of the gamma-secretase inhibitor avagacestat in a phase 2 study of mild to moderate Alzheimer disease. Arch Neurol. 2012 Nov;69(11):1430-40.