Details of the Drug

General Information of Drug (ID: )

• #Ro5 Violations (Lipinski): 1:
  Molecular Weight (mw)
  Logarithm of the Partition Coefficient (xlogp)
  Rotatable Bond Count (rotbonds)
  Hydrogen Bond Donor Count (hbonddonor)
  Hydrogen Bond Acceptor Count (hbondacc)
• ADMET Property:
  Absorption Tmax: The time to maximum plasma concentration (Tmax) is 1.5-2 h [1]
  Bioavailability: The bioavailability of drug is 60-80% [1]
  Clearance: The renal clearance of drug is 3.0-3.5 mL/min [2]
  Elimination: 20% of a radiolabelled oral dose is recovered in urine, and the rest is recovered in the feces, only less than 2% of the dose is recovered in urine as the unchanged drug [3]
  Half-life: The concentration or amount of drug in body reduced by one-half in 11 - 15 hours [2]
  Metabolism: The drug is metabolized via the glucuronidation and oxidation in the liver [4]
  Vd: The volume of distribution (Vd) of drug is 53-93 L [2]

References

• [1] Marino MR, Langenbacher K, Ford NF, Uderman HD: Pharmacokinetics and pharmacodynamics of irbesartan in healthy subjects. J Clin Pharmacol. 1998 Mar;38(3):246-55.
• [2] FDA Approved Drug Products: Irbesartan Oral Tablets
• [3] Sandoz Canada: Irbesartan Product Monograph
• [4] Vickers AE, Sinclair JR, Zollinger M, Heitz F, Glanzel U, Johanson L, Fischer V: Multiple cytochrome P-450s involved in the metabolism of terbinafine suggest a limited potential for drug-drug interactions. Drug Metab Dispos. 1999 Sep;27(9):1029-38.