Details of the Drug

General Information of Drug (ID: DM63NX5)

Drug Name
1,3-dihydroxy phenyl derivative 2
Synonyms PMID30107136-Compound-Example6
Indication
Disease Entry ICD 11 Status REF
Hepatitis DB97.Z Patented [1]
Human immunodeficiency virus infection 1C62 Patented [1]
Infectious disease 1A00-CA43.1 Patented [1]
Solid tumour/cancer 2A00-2F9Z Patented [1]
Drug Type
Small molecule immunotherapy
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 2 Molecular Weight (mw) 624.1
Logarithm of the Partition Coefficient (xlogp) 1.7
Rotatable Bond Count (rotbonds) 12
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 10
Chemical Identifiers
Formula
C34H30ClN5O5
IUPAC Name
(2R)-2-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[(2-methyl-3-quinoxalin-2-ylphenyl)methoxy]phenyl]methylamino]-3-hydroxy-2-methylpropanoic acid
Canonical SMILES
CC1=C(C=CC=C1C2=NC3=CC=CC=C3N=C2)COC4=C(C=C(C(=C4)OCC5=CC(=CN=C5)C#N)CN[C@](C)(CO)C(=O)O)Cl
InChI
InChI=1S/C34H30ClN5O5/c1-21-24(6-5-7-26(21)30-17-38-28-8-3-4-9-29(28)40-30)19-45-32-12-31(44-18-23-10-22(13-36)14-37-15-23)25(11-27(32)35)16-39-34(2,20-41)33(42)43/h3-12,14-15,17,39,41H,16,18-20H2,1-2H3,(H,42,43)/t34-/m1/s1
InChIKey
KJGBSKXWCFJEDI-UUWRZZSWSA-N
Cross-matching ID
PubChem CID
138748934
TTD ID
D0XV7Y
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) TT23XQV PDCD1_HUMAN-PD1L1_HUMAN Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678.