Details of the Drug

General Information of Drug (ID: DM67EMK)

Drug Name
SCH-900776
Synonyms
CHEMBL1643208; MK-8776; 6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine; GTPL7943; SCHEMBL10380123; CHEBI:131165; HMS3656J19; BCP02883; BDBM50334854; AKOS026750519; MK 8776; NCGC00387868-02; DA-40779; 4CA-1150; BCP0726000317; J3.517.083I; 891494-63-6 pound not SCH900776 pound not SCH-900776; 6-bromo-3-(1-methylpyrazol-4-yl)-5-piperidin-3-ylpyrazolo[5,1-b]pyrimidin-7-amine; 6-bromo-3-(1-methylpyrazol-4-yl)-5-[(3S)-piperidin-3-yl]pyrazolo[1,5-a]pyrimidin-7-amine
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 376.25
Logarithm of the Partition Coefficient (xlogp) 0.8
Rotatable Bond Count (rotbonds) 2
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 5
Chemical Identifiers
Formula
C15H18BrN7
IUPAC Name
6-bromo-3-(1-methylpyrazol-4-yl)-5-[(3R)-piperidin-3-yl]pyrazolo[1,5-a]pyrimidin-7-amine
Canonical SMILES
CN1C=C(C=N1)C2=C3N=C(C(=C(N3N=C2)N)Br)[C@@H]4CCCNC4
InChI
InChI=1S/C15H18BrN7/c1-22-8-10(6-19-22)11-7-20-23-14(17)12(16)13(21-15(11)23)9-3-2-4-18-5-9/h6-9,18H,2-5,17H2,1H3/t9-/m1/s1
InChIKey
GMIZZEXBPRLVIV-SECBINFHSA-N
Cross-matching ID
PubChem CID
46239015
CAS Number
891494-63-6
UNII
K2ZSF0992C
DrugBank ID
DB11899
TTD ID
D05FWH
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Checkpoint kinase-1 (CHK1) TTTU902 CHK1_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Solid tumour/cancer
ICD Disease Classification 2A00-2F9Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Checkpoint kinase-1 (CHK1) DTT CHEK1 7.22E-191 1.43 4.74
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC2 3.1484 6.1247 1.0575 5.8938
ES1 GDSC2 -0.6329 2.1035 -0.8459 30.7215
EW-7 GDSC2 -0.2728 4.341 -1.235 30.7942
SK-PN-DW GDSC2 0.0525 2.6333 -0.2463 24.3517
EW-12 GDSC2 0.1351 5.5671 -1.3532 29.4754
EW-22 GDSC2 0.385 4.8977 -0.7979 25.8064
EW-18 GDSC2 0.8319 4.7471 -0.2803 21.2374
ES4 GDSC2 1.287 3.7136 0.648 14.0463
SK-ES-1 GDSC2 1.9077 6.4723 -0.1078 16.4229
U2OS GDSC2 1.9994 5.3291 0.5417 12.2194
CAL-72 GDSC2 2.4285 5.8642 0.6388 10.3259
ES5 GDSC2 2.5425 8.4448 -0.5577 16.9997
ES6 GDSC2 2.6421 5.7748 0.8545 8.3902
EW-1 GDSC2 2.7187 5.0312 1.2821 5.5157
MG-63 GDSC2 2.8758 4.7433 1.536 3.5776
TC-71 GDSC2 2.9866 4.8341 1.5672 3.1564
CADO-ES1 GDSC2 3.0762 5.1059 1.4972 3.3925
EW-24 GDSC2 3.098 6.3292 0.9225 6.833
NY GDSC2 3.1595 8.1123 0.0916 11.6784
CAL-78 GDSC2 3.2245 9.7646 -0.6766 15.752
NOS-1 [Human HNSCC] GDSC2 3.2675 8.4213 0.0199 11.8222
ES7 GDSC2 3.3014 6.0355 1.2042 4.6824
CHSA0108 GDSC2 3.4936 13.1902 -2.1693 21.7916
EW-16 GDSC2 3.5133 7.0481 0.8628 6.2789
A-673 GDSC2 3.563 7.189 0.8288 6.3773
EW-3 GDSC2 3.6368 7.3602 0.7963 6.4171
ES8 GDSC2 3.6687 7.5116 0.7455 6.6504
EW-11 GDSC2 3.7322 10.8126 -0.8131 15.1726
H-EMC-SS GDSC2 3.7675 6.7341 1.1725 3.9903
SJSA-1 GDSC2 3.8146 8.2908 0.4712 7.9492
MHH-ES-1 GDSC2 3.8253 6.893 1.1345 4.1042
HuO9 GDSC2 3.8438 8.6623 0.3129 8.8006
HOS GDSC2 4.0016 9.2384 0.1436 9.4254
HuO-3N1 GDSC2 4.0286 9.3361 0.115 9.5286
U-CH2 GDSC2 4.3263 6.3658 1.6265 1.0173
CHSA8926 GDSC2 4.379 6.0848 1.7569 0.532
SaOS-2 GDSC2 4.6358 6.3088 1.7761 0.3574
CHSA0011 GDSC2 4.9577 10.2369 0.2856 6.8192
G-292 clone A141B1 GDSC2 4.9621 6.7492 1.7425 0.3117
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 164 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC2 1.1124 3.2818 0.6561 14.6877
EoL-1 GDSC2 -5.1643 -2.8069 -5.1663 74.1168
MOLM-13 GDSC2 -1.391 0.3152 -1.4039 37.3222
SR GDSC2 -1.258 0.1968 -1.2639 35.9538
JURL-MK1 GDSC2 -1.0964 0.5773 -1.1133 34.3871
JeKo-1 GDSC2 -1.0111 0.7541 -1.0361 33.5714
DEL GDSC2 -1.009 -0.0271 -1.0096 33.4292
PL-21 GDSC2 -0.9837 0.7108 -1.0046 33.2766
MLMA GDSC2 -0.9516 1.6695 -1.0959 33.5525
OCI-Ly7 GDSC2 -0.8803 1.0666 -0.9268 32.3666
SUP-B8 GDSC2 -0.8579 2.0851 -1.0866 33.0214
ATN-1 GDSC2 -0.7598 1.3462 -0.8339 31.297
NU-DUL-1 GDSC2 -0.7427 0.3296 -0.7445 30.7632
Kasumi-1 GDSC2 -0.5661 1.4501 -0.6417 29.3645
NB4 GDSC2 -0.5582 0.6593 -0.5643 28.9329
JVM-3 GDSC2 -0.4782 2.0449 -0.663 29.0417
KE-37 GDSC2 -0.4765 0.3278 -0.4769 28.0847
Karpas-299 GDSC2 -0.4575 0.7984 -0.4663 27.9363
SKM-1 GDSC2 -0.4431 1.2613 -0.4858 27.9638
RCH-ACV GDSC2 -0.4389 1.6371 -0.5355 28.1976
MV4-11 GDSC2 -0.402 1.7778 -0.5218 27.9476
L-363 GDSC2 -0.3718 0.8151 -0.3791 27.0683
SU-DHL-5 GDSC2 -0.3088 0.8094 -0.3145 26.4284
CML-T1 GDSC2 -0.2699 0.7475 -0.2733 26.0265
P32/ISH GDSC2 -0.2288 0.9816 -0.2395 25.6508
HC-1 GDSC2 -0.131 4.9619 -1.3529 30.6527
EJM GDSC2 -0.1119 1.3731 -0.1478 24.6061
CCRF-CEM GDSC2 -0.0778 0.9378 -0.0829 24.1068
WSU-NHL GDSC2 -0.0631 2.6904 -0.3901 25.6516
Mono-Mac-6 GDSC2 -0.0366 2.7575 -0.3829 25.4912
BALL-1 GDSC2 -0.0008 1.1098 -0.0109 23.3598
VAL GDSC2 0.0084 2.4538 -0.2401 24.5211
DND-41 GDSC2 0.0649 1.2437 0.0491 22.7293
MOLT-16 GDSC2 0.0705 0.864 0.0691 22.6004
A4/Fukuda GDSC2 0.0751 2.3996 -0.1517 23.739
NKM-1 GDSC2 0.0764 13.628 -5.2965 39.6172
RPMI-8402 GDSC2 0.0989 1.0537 0.0937 22.3342
Hs 445 GDSC2 0.1166 3.2118 -0.3753 24.7561
BONNA-12 GDSC2 0.1211 2.2038 -0.0487 22.973
SCC-3 GDSC2 0.1278 3.3972 -0.433 25.0155
ML-2 GDSC2 0.1355 1.01 0.1322 21.9576
697 GDSC2 0.1466 1.9999 0.0275 22.4476
WIL2 NS GDSC2 0.1878 1.1805 0.1798 21.4568
SU-DHL-8 GDSC2 0.1968 1.2508 0.1855 21.3828
EB2 GDSC2 0.205 3.0579 -0.2241 23.5429
H9 GDSC2 0.2117 1.8044 0.1368 21.5615
SUP-M2 GDSC2 0.2927 1.3604 0.278 20.4377
BV-173 GDSC2 0.3254 2.1977 0.1757 20.8189
CRO-AP2 GDSC2 0.3263 3.3343 -0.197 22.8608
LAMA-84 GDSC2 0.3429 3.2949 -0.1641 22.6066
THP-1 GDSC2 0.358 3.5996 -0.2678 23.1138
A3/Kawakami GDSC2 0.3596 2.5523 0.1133 21.0005
JVM-2 GDSC2 0.3655 3.5705 -0.2482 22.9737
MOLM-16 GDSC2 0.3707 2.5651 0.1214 20.9064
EM-2 GDSC2 0.3784 1.4574 0.3599 19.5972
QIMR-WIL GDSC2 0.3804 2.4652 0.1623 20.6389
ARH-77 GDSC2 0.3988 2.1601 0.265 19.9978
HEL GDSC2 0.4247 3.1221 -0.0113 21.4027
CTV-1 GDSC2 0.4973 2.3326 0.3278 19.2032
TK [Human B-cell lymphoma] GDSC2 0.5149 2.1394 0.3965 18.7513
P31/FUJ GDSC2 0.5222 2.286 0.3675 18.8737
Karpas-231 GDSC2 0.5248 1.7246 0.4856 18.235
BC-1 GDSC2 0.5285 2.6535 0.2651 19.4061
RPMI-6666 GDSC2 0.5321 2.4795 0.3234 19.0691
AMO1 GDSC2 0.535 1.8996 0.4688 18.273
IM-9 GDSC2 0.5919 4.439 -0.3825 22.7634
CTB-1 GDSC2 0.6148 3.4173 0.0769 20.0929
OCI-AML-2 GDSC2 0.6228 3.0462 0.2295 19.1929
P12-Ichikawa GDSC2 0.6243 1.8561 0.5725 17.3015
MOLP-8 GDSC2 0.6923 4.353 -0.242 21.5781
Farage GDSC2 0.6931 3.6097 0.0807 19.7448
SU-DHL-1 GDSC2 0.8337 6.6845 -1.1968 25.9345
ST486 GDSC2 0.8573 3.6267 0.2449 18.1254
SUP-HD1 GDSC2 1.0301 4.0092 0.2549 17.3793
HAL-01 GDSC2 1.0382 2.587 0.8405 13.9437
NK-92MI GDSC2 1.1166 2.5367 0.9422 13.0296
Loucy GDSC2 1.1494 2.8013 0.8856 13.2057
OCI-Ly19 GDSC2 1.1669 3.7647 0.5033 15.3748
Granta-519 GDSC2 1.2094 3.3127 0.7443 13.7778
KY821 GDSC2 1.2338 3.831 0.5413 14.8894
Karpas-1106P GDSC2 1.2779 4.7417 0.1607 17.0008
GR-ST GDSC2 1.3745 4.044 0.5838 14.102
SU-DHL-16 GDSC2 1.4068 3.6976 0.7759 12.819
MOLT-13 GDSC2 1.429 4.6589 0.3457 15.3449
JSC-1 GDSC2 1.4369 5.3846 0.0024 17.3643
GDM-1 GDSC2 1.4787 3.5275 0.9257 11.6418
L-540 GDSC2 1.4924 4.1931 0.6291 13.3943
GA-10 GDSC2 1.5033 4.0687 0.6987 12.9299
ALL-SIL GDSC2 1.52 3.4297 1.0116 10.9659
LC4-1 GDSC2 1.5324 5.5504 0.0103 16.9846
WSU-DLCL2 GDSC2 1.5401 5.1058 0.2347 15.6225
OPM-2 GDSC2 1.5469 3.7777 0.8782 11.6745
ALL-PO GDSC2 1.595 3.9597 0.8395 11.736
L-428 GDSC2 1.642 5.1605 0.3027 14.8606
TALL-1 [Human adult T-ALL] GDSC2 1.642 4.9738 0.394 14.3052
MM1.S GDSC2 1.6953 3.6854 1.067 9.9767
SIG-M5 GDSC2 1.7238 2.7714 1.5086 7.2031
KCL-22 GDSC2 1.7961 6.3212 -0.1312 16.9213
PF-382 GDSC2 1.8028 3.7134 1.1573 9.0363
SUP-T1 GDSC2 1.8194 8.0711 -0.9815 21.4155
NOMO-1 GDSC2 1.8407 2.893 1.5776 6.3282
MHH-CALL-2 GDSC2 1.8758 6.6435 -0.2211 17.1774
OCI-M1 GDSC2 1.9058 2.8362 1.6692 5.5271
HT GDSC2 1.9277 6.7736 -0.2404 17.1205
Daudi GDSC2 1.9603 4.6875 0.8257 10.5747
YT GDSC2 2.0099 4.1769 1.1231 8.5484
MHH-CALL-4 GDSC2 2.0366 5.8744 0.3026 13.5712
KOPN-8 GDSC2 2.0784 5.3675 0.5918 11.6608
OCI-AML-5 GDSC2 2.0908 4.0951 1.2361 7.5774
OCI-AML-3 GDSC2 2.1331 4.9086 0.8681 9.7634
L-1236 GDSC2 2.1396 5.8601 0.3987 12.6652
TUR GDSC2 2.1512 4.8407 0.9175 9.3971
MHH-PREB-1 GDSC2 2.1678 4.935 0.8848 9.5523
Namalwa GDSC2 2.2052 4.752 1.0083 8.6605
MEG-01 GDSC2 2.2282 5.1008 0.8536 9.5659
Ramos.2G6.4C10 GDSC2 2.252 3.5921 1.6277 4.6029
DG-75 GDSC2 2.2812 5.4598 0.7189 10.2532
SU-DHL-10 GDSC2 2.295 3.5732 1.6737 4.1831
SUP-B15 GDSC2 2.2993 3.7465 1.5907 4.696
SU-DHL-4 GDSC2 2.2999 5.7647 0.5822 11.0506
MC116 GDSC2 2.3317 5.3292 0.8264 9.4315
Karpas-422 GDSC2 2.3327 6.4538 0.265 12.8998
CESS GDSC2 2.337 4.6271 1.1819 7.1739
Jurkat GDSC2 2.3621 5.0506 0.9909 8.3079
K-562 GDSC2 2.3695 4.8024 1.1211 7.4642
RC-K8 GDSC2 2.3984 5.4783 0.807 9.3607
BE-13 GDSC2 2.4176 4.65 1.2366 6.5979
RS4;11 GDSC2 2.4254 5.832 0.6524 10.25
U-698-M GDSC2 2.4479 5.0701 1.0514 7.6828
NALM-6 GDSC2 2.4714 4.3138 1.4477 5.1158
KG-1 GDSC2 2.4798 4.2205 1.5008 4.7575
DoHH2 GDSC2 2.5002 4.1728 1.5405 4.4528
KMS-11 GDSC2 2.5192 6.2998 0.4949 10.9596
BC-3 GDSC2 2.5222 5.642 0.8257 8.8962
BL-41 GDSC2 2.5299 4.9683 1.1678 6.7233
Karpas-45 GDSC2 2.5837 4.9229 1.2326 6.1717
RPMI-8866 GDSC2 2.592 5.7833 0.8108 8.7981
KMS-12-BM GDSC2 2.6099 4.8592 1.2846 5.7766
Raji GDSC2 2.6599 5.2556 1.1263 6.6406
Ku812 GDSC2 2.706 5.4924 1.0443 7.0354
JJN-3 GDSC2 2.7223 6.1428 0.7341 8.9279
RL GDSC2 2.7484 4.7307 1.4518 4.3859
MOLT-4 GDSC2 2.8143 4.4929 1.6143 3.235
CA46 GDSC2 2.8301 5.1831 1.2896 5.1984
P30/OHK GDSC2 2.939 6.4395 0.7521 8.2623
MY-M12 GDSC2 3.0936 5.6096 1.2682 4.7325
RPMI-8226 GDSC2 3.1479 6.5897 0.8311 7.2757
HDLM-2 GDSC2 3.1719 6.3363 0.9714 6.3651
ME1 GDSC2 3.2502 5.4738 1.4361 3.4139
Karpas-620 GDSC2 3.2519 4.7279 1.777 1.5068
VL51 GDSC2 3.2662 7.0733 0.6798 7.9198
SU-DHL-6 GDSC2 3.2834 5.7032 1.3497 3.8569
MN-60 GDSC2 3.2909 5.7921 1.3126 4.0604
U266B1 GDSC2 3.3713 6.6415 0.9617 5.9876
HL-60 GDSC2 3.5322 5.2668 1.6938 1.5486
NCI-H929 GDSC2 3.5773 5.4059 1.6578 1.6691
LP-1 GDSC2 3.5951 6.8776 0.9976 5.3172
Reh GDSC2 3.6027 6.2089 1.3137 3.4797
ROS-50 GDSC2 3.6502 9.5815 -0.2693 12.5144
DB GDSC2 3.6533 6.1123 1.3877 2.9834
HH [Human lymphoma] GDSC2 3.7874 7.2368 0.952 5.2129
KMOE-2 GDSC2 4.3104 6.3975 1.6067 1.1079
KM-H2 GDSC2 4.8805 14.3399 -1.7114 16.6941
SK-MM-2 GDSC2 5.1231 6.6864 1.8219 0.1379
⏷ Show the Full List of 164 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESO-51 GDSC2 -1.4144 1.3982 -1.5456 38.0711
ESO-26 GDSC2 2.9589 6.1212 0.9234 7.1567
OACM5.1 C GDSC2 2.9668 5.9443 1.016 6.5666
OACP4 C GDSC2 3.2628 6.9254 0.7493 7.5076
KYSE-220 GDSC2 3.5458 7.0265 0.8948 6.0224
HCE-4 GDSC2 3.7672 7.3763 0.8738 5.704
KYSE-50 GDSC2 3.8823 8.6756 0.3326 8.6053
KYAE-1 GDSC2 4.0564 6.4208 1.4737 1.9645
TE-12 GDSC2 4.103 7.0133 1.2416 3.0768
FLO-1 GDSC2 4.2718 7.6313 1.0622 3.7736
SK-GT-4 GDSC2 4.3624 9.1459 0.4235 7.1334
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC2 2.853 6.2192 0.7963 8.2051
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Kelly GDSC2 -1.6767 -0.2469 -1.6795 40.1402
SiMa GDSC2 -0.008 2.4912 -0.269 24.752
KP-N-YN GDSC2 0.0154 3.6227 -0.6402 26.6075
SJNB-14 GDSC2 0.0175 0.947 0.0139 23.1432
KP-N-YS GDSC2 0.8963 2.8118 0.6093 15.8639
LA-N-6 GDSC2 1.0344 5.078 -0.2353 20.2042
SK-N-MC-IXC GDSC2 1.0539 6.5509 -0.9241 23.7976
SJNB-17 GDSC2 1.1676 2.7808 0.9127 12.9729
MHH-NB-11 GDSC2 1.2108 3.6599 0.5947 14.6595
SJNB-13 GDSC2 1.3621 3.7166 0.7224 13.3113
GOTO GDSC2 1.4404 4.8781 0.2512 15.8736
SK-N-DZ GDSC2 1.9293 3.2219 1.5139 6.3848
IMR-5 GDSC2 2.22 6.4921 0.1513 13.921
CHP-126 GDSC2 2.2434 5.4708 0.6816 10.5986
SK-N-AS GDSC2 2.407 6.1663 0.4702 11.431
NB(TU)1 GDSC2 2.5679 7.176 0.0967 13.229
NH-12 GDSC2 2.6337 7.4754 0.0002 13.6108
CHP-212 GDSC2 2.6356 5.8607 0.8067 8.7062
CHP-134 GDSC2 2.8211 5.1851 1.282 5.2666
KP-N-RT-BM-1 GDSC2 2.8271 6.4965 0.6392 9.2409
TGW GDSC2 2.9637 6.0727 0.9508 6.9764
SJNB-6 GDSC2 3.023 7.1358 0.4713 9.7671
SK-N-FI GDSC2 3.132 5.9945 1.1091 5.6159
SK-N-SH GDSC2 3.2854 7.3144 0.576 8.5006
SJNB-10 GDSC2 3.3019 8.844 -0.1628 12.7741
NB1 GDSC2 3.6854 8.1574 0.4474 8.363
GI-ME-N GDSC2 3.9679 12.1433 -1.2937 16.916
SJNB-5 GDSC2 3.9824 8.3446 0.5566 7.1142
SJNB-12 GDSC2 4.2185 6.6622 1.4543 1.8632
SK-N-BE(2)-M17 GDSC2 4.2472 6.7586 1.4283 1.9517
SJNB-7 GDSC2 4.3626 6.3312 1.6561 0.8775
NB69 GDSC2 4.5747 6.8804 1.535 1.1636
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC2 2.9027 8.3391 -0.2174 14.1196
Cancer Drug Sensitivity Data Curated from 50 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC2218 GDSC2 -1.9382 38.2985 -19.3293 49.02
HCC1806 GDSC2 -0.4238 1.289 -0.4685 27.7804
HCC1395 GDSC2 -0.3086 2.4578 -0.5871 27.835
MDA-MB-361 GDSC2 -0.2221 1.7404 -0.32 26.0319
HCC1599 GDSC2 0.3331 4.9189 -0.86 26.3352
HCC1569 GDSC2 0.9683 3.6391 0.3546 17.0376
MDA-MB-157 GDSC2 1.792 4.9005 0.5682 12.7287
HCC38 GDSC2 1.9515 6.0533 0.1392 14.8265
Hs 578T GDSC2 2.0081 5.2282 0.5997 11.832
HCC70 GDSC2 2.4051 5.9184 0.5925 10.6805
HCC1937 GDSC2 2.5578 8.5087 -0.5771 17.0595
BT-549 GDSC2 2.8491 6.915 0.4485 10.3506
YMB-1-E GDSC2 2.8739 6.0734 0.884 7.609
MRK-nu-1 GDSC2 3.1365 5.7902 1.2107 4.9886
AU565 GDSC2 3.1439 7.6164 0.3246 10.3464
HCC1419 GDSC2 3.1782 7.991 0.1655 11.2002
MDA-MB-231 GDSC2 3.3547 5.6822 1.4046 3.4021
MDA-MB-436 GDSC2 3.3902 7.0981 0.7549 7.188
CAL-120 GDSC2 3.4893 6.7889 0.9704 5.6899
JIMT-1 GDSC2 3.5363 6.1519 1.2995 3.6767
MFM-223 GDSC2 3.5469 7.0144 0.9013 5.9812
CAL-148 GDSC2 3.6462 5.4142 1.6901 1.4239
DU4475 GDSC2 3.7608 13.3492 -2.0432 20.6292
MDA-MB-175-VII GDSC2 3.798 5.4708 1.7413 1.0269
Evsa-T GDSC2 3.8158 5.5857 1.7029 1.1755
EFM-19 GDSC2 3.8258 7.9518 0.6401 6.946
CAMA-1 GDSC2 3.8265 6.0697 1.5036 2.1129
CAL-51 GDSC2 3.8921 8.7341 0.3112 8.7068
BT-20 GDSC2 3.9241 9.3019 0.0601 10.0618
HCC1143 GDSC2 3.9754 11.3239 -0.8864 14.9573
UACC-893 GDSC2 4.0529 9.8966 -0.1379 10.877
BT-483 GDSC2 4.129 6.9129 1.3 2.7359
COLO 824 GDSC2 4.1681 7.3935 1.1093 3.6813
MDA-MB-453 GDSC2 4.1997 11.045 -0.5911 12.9562
HCC1187 GDSC2 4.2244 6.0021 1.7235 0.7386
UACC-812 GDSC2 4.2246 7.9797 0.8774 4.8546
MDA-MB-415 GDSC2 4.2343 6.145 1.6722 0.9177
HDQ-P1 GDSC2 4.284 6.0305 1.738 0.6487
HCC2157 GDSC2 4.3121 6.8897 1.4059 1.9812
BT-474 GDSC2 4.3401 5.6982 1.8818 0.2325
EFM-192A GDSC2 4.4405 6.0979 1.7767 0.4432
MDA-MB-468 GDSC2 4.4741 9.2945 0.4243 6.922
OCUB-M GDSC2 4.4846 6.5574 1.6216 0.9109
MCF-7 GDSC2 4.5842 8.5397 0.8346 4.504
HCC1428 GDSC2 4.6881 6.3772 1.7716 0.3473
ZR-75-30 GDSC2 4.7732 6.7282 1.6773 0.5507
CAL-85-1 GDSC2 4.9178 7.1051 1.5959 0.7104
HCC1954 GDSC2 5.0349 7.0153 1.6752 0.4352
MDA-MB-330 GDSC2 5.3766 7.8683 1.4982 0.7446
T-47D GDSC2 5.6766 7.8685 1.6133 0.3409
⏷ Show the Full List of 50 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 53 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SF539 GDSC2 0.4187 2.5556 0.1767 20.3862
ONS-76 GDSC2 0.4431 3.558 -0.1611 22.1594
KALS-1 GDSC2 1.1903 5.9434 -0.5008 21.0963
D283 Med GDSC2 1.3249 3.8204 0.6377 13.9624
SW1783 GDSC2 1.9222 5.3506 0.4628 12.953
SF295 GDSC2 2.2902 5.5273 0.6927 10.3905
T98G GDSC2 2.3084 4.7512 1.096 7.8
LN-229 GDSC2 2.4226 5.2563 0.9377 8.4705
CAS-1 GDSC2 2.4279 7.4017 -0.1302 14.956
D-423MG GDSC2 2.5848 7.812 -0.2073 14.9437
PFSK-1 GDSC2 2.7202 5.8327 0.8864 7.9857
YKG-1 GDSC2 3.0512 4.6254 1.7063 2.2178
42-MG-BA GDSC2 3.1567 7.8313 0.2282 10.8854
U-87MG ATCC GDSC2 3.1874 5.2918 1.4814 3.2686
NMC-G1 GDSC2 3.189 6.0863 1.1042 5.5207
AM-38 GDSC2 3.2269 8.2959 0.0515 11.7418
KINGS-1 GDSC2 3.2442 6.5455 0.9206 6.512
MOG-G-UVW GDSC2 3.2876 5.9795 1.2218 4.6056
SK-MG-1 GDSC2 3.2964 6.5354 0.9616 6.1493
LN-405 GDSC2 3.3484 7.7976 0.3852 9.4916
Daoy GDSC2 3.3984 6.4577 1.0677 5.2974
U-118MG GDSC2 3.4015 8.9381 -0.1353 12.3728
SW1088 GDSC2 3.4383 7.0932 0.7904 6.8702
GB-1 GDSC2 3.4879 5.2576 1.6741 1.7068
D-542MG GDSC2 3.5495 6.12 1.3223 3.524
H4 GDSC2 3.6168 9.0055 -0.0118 11.1615
Hs 683 GDSC2 3.6372 6.2299 1.3248 3.3582
D-566MG GDSC2 3.6416 5.2458 1.7583 1.113
8-MG-BA GDSC2 3.6844 5.688 1.5928 1.853
LN-18 GDSC2 3.7419 11.8215 -1.3027 17.5045
M059J GDSC2 3.8532 6.2558 1.4369 2.4174
D-245MG GDSC2 3.8612 6.6739 1.2555 3.3731
D-336MG GDSC2 3.9073 10.5583 -0.5614 13.4685
YH-13 GDSC2 3.9756 12.9514 -1.6855 18.633
Onda 10 GDSC2 3.9802 6.176 1.5384 1.7466
Onda 11 GDSC2 3.9974 9.9228 -0.189 11.2778
KNS-42 GDSC2 4.0156 6.4109 1.4567 2.0985
GaMG GDSC2 4.065 6.7533 1.3349 2.646
KS-1 [Human Krukenberg tumour] GDSC2 4.1988 6.838 1.3696 2.2931
D-502MG GDSC2 4.2501 6.3749 1.588 1.2387
A-172 GDSC2 4.2574 10.9297 -0.4952 12.3338
Becker GDSC2 4.397 12.2436 -1.034 14.71
SF126 GDSC2 4.4028 5.6909 1.9072 0.1667
DK-MG GDSC2 4.5054 5.8486 1.8897 0.17
MOG-G-CCM GDSC2 4.5379 6.7609 1.5656 1.0768
D-247MG GDSC2 4.6019 6.9193 1.5318 1.1534
KNS-81-FD GDSC2 4.727 6.6235 1.6974 0.5181
D-392MG GDSC2 4.7285 7.0462 1.5383 1.0292
D-263MG GDSC2 4.743 6.5554 1.7286 0.4285
SNB-75 GDSC2 5.1196 7.1596 1.6558 0.4469
U-251MG GDSC2 5.7071 12.6062 -0.3478 8.7822
SF268 GDSC2 5.9362 17.5107 -2.5123 17.6889
DBTRG-05MG GDSC2 6.3587 14.4335 -0.792 9.8032
⏷ Show the Full List of 53 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC24TKB GDSC2 2.9845 4.8085 1.578 3.0959
TGBC1TKB GDSC2 3.5488 5.5919 1.5608 2.2104
ETK-1 GDSC2 4.522 7.4739 1.2661 2.3939
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESS-1 GDSC2 0.3948 3.8218 -0.3199 23.242
MFE-319 GDSC2 2.4115 5.6509 0.7314 9.7967
EN GDSC2 3.0854 6.2277 0.963 6.6143
AN3-CA GDSC2 3.5989 6.3156 1.2624 3.7773
RL95-2 GDSC2 3.933 5.7191 1.7043 1.0531
MFE-280 GDSC2 4.03 7.9213 0.7854 5.7151
KLE GDSC2 4.2095 8.8952 0.4438 7.3107
MFE-296 GDSC2 4.5129 17.6726 -3.6127 24.2473
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ACHN GDSC2 0.0342 2.0546 -0.1072 23.6919
LB2241-RCC GDSC2 0.4142 2.8273 0.0829 20.9245
769-P GDSC2 0.5794 6.9035 -1.5447 28.4539
786-O GDSC2 1.7371 5.4455 0.2495 14.8614
KTCTL-13 GDSC2 1.9079 6.3501 -0.0468 16.067
CAL-54 GDSC2 2.338 7.447 -0.2272 15.7765
BFTC-909 GDSC2 2.3536 6.2463 0.3861 12.1019
A-498 GDSC2 2.3842 6.731 0.1691 13.3263
KMRC-20 GDSC2 2.6519 5.5128 0.9924 7.5013
A-704 GDSC2 2.7523 7.7228 -0.0288 13.4505
KTCTL-26A GDSC2 2.7907 5.821 0.946 7.4328
KTCTL-140 GDSC2 2.7912 5.5973 1.057 6.7403
LB1047-RCC GDSC2 2.862 6.0154 0.9037 7.5167
UO-31 GDSC2 3.109 6.9255 0.6386 8.5408
BB65-RCC GDSC2 3.14 5.6919 1.2603 4.6813
RXF 393L GDSC2 3.1615 8.7045 -0.1996 13.3373
Caki-1 GDSC2 3.1969 5.6936 1.2977 4.3379
RCC10RGB GDSC2 3.2572 5.6848 1.3414 3.9565
VMRC-RCW GDSC2 3.3755 7.0311 0.7771 7.087
LB996-RCC GDSC2 3.4265 8.1249 0.2815 9.9187
SW13 GDSC2 3.5486 8.3674 0.2505 9.8163
TK-10 GDSC2 3.5528 6.8408 0.9875 5.4603
VMRC-RCZ GDSC2 3.6328 5.4811 1.6547 1.6124
NCC021 GDSC2 3.6526 7.6709 0.6586 7.1949
SN12C GDSC2 3.6623 8.317 0.3546 8.9547
KMRC-1 GDSC2 3.6727 6.6547 1.1511 4.2805
SW156 GDSC2 3.7469 6.7984 1.1304 4.2653
HA7-RCC GDSC2 3.7483 8.6468 0.2549 9.3411
OS-RC-2 GDSC2 3.8055 8.7917 0.2244 9.3903
NCC010 GDSC2 4.3844 6.8376 1.4633 1.6402
KTCTL-21 GDSC2 4.5133 8.7953 0.6778 5.4629
KTCTL-1M GDSC2 4.6757 7.1931 1.4566 1.3863
KTCTL-195 GDSC2 5.0269 6.6173 1.8116 0.171
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 43 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 320HSR GDSC2 0.7757 4.7786 -0.3508 21.8501
T84 GDSC2 1.1935 3.7291 0.5462 15.0159
LS411N GDSC2 1.6963 5.6176 0.1275 15.7313
CCK-81 GDSC2 1.8278 7.3503 -0.615 19.5077
CL-11 GDSC2 1.8716 4.843 0.6689 11.8419
NCI-H716 GDSC2 2.0471 4.9213 0.7866 10.5425
SNU-283 GDSC2 2.3184 6.1843 0.3878 12.1945
DiFi GDSC2 2.4504 6.2464 0.4657 11.334
SW48 GDSC2 2.5835 4.4488 1.4678 4.6932
SNU-C5 GDSC2 2.6884 6.5328 0.5135 10.3802
SNU-C1 GDSC2 2.7459 5.5274 1.0574 6.8517
SNU-C2B GDSC2 2.7637 6.6152 0.5314 10.0694
HCT 116 GDSC2 2.8228 5.2618 1.2456 5.4886
HT-29 GDSC2 2.9981 7.1893 0.4262 10.1025
GP5d GDSC2 3.0523 6.8026 0.6573 8.5644
HCC2998 GDSC2 3.0896 5.8598 1.1447 5.4929
HCT 15 GDSC2 3.1656 7.7137 0.2928 10.4815
RKO GDSC2 3.2123 6.8685 0.7412 7.6729
LS1034 GDSC2 3.2435 5.5243 1.4082 3.5902
SW948 GDSC2 3.2904 6.7086 0.8739 6.692
COLO205 GDSC2 3.3085 6.7624 0.8605 6.7331
SNU-175 GDSC2 3.3396 7.0334 0.751 7.324
SW1116 GDSC2 3.5113 5.6674 1.5056 2.5654
LS180 GDSC2 3.5129 7.1224 0.827 6.4928
NCI-H508 GDSC2 3.5222 9.2529 -0.2013 12.4467
KM12 GDSC2 3.6051 6.9503 0.9699 5.4602
SK-CO-1 GDSC2 3.6614 7.3379 0.8232 6.2091
CW-2 GDSC2 3.6821 6.1795 1.3741 3.0113
LoVo GDSC2 3.7215 13.7109 -2.2524 21.5393
SNU-81 GDSC2 3.8931 5.8797 1.619 1.4702
SW626 GDSC2 4.0642 7.8729 0.8291 5.405
HT-55 GDSC2 4.0682 5.7272 1.7621 0.7153
SW1417 GDSC2 4.2783 6.141 1.6931 0.8069
SW1463 GDSC2 4.3451 5.9742 1.7842 0.4707
NCI-H747 GDSC2 4.4416 7.244 1.3223 2.2228
HT115 GDSC2 4.4754 6.079 1.7972 0.3734
COLO 678 GDSC2 4.496 6.2838 1.7303 0.5457
CaR-1 GDSC2 4.5026 6.7301 1.5619 1.1199
SW837 GDSC2 4.5191 6.9717 1.4729 1.4644
SW620 GDSC2 4.5732 6.5331 1.6686 0.6902
RCM-1 [Human ESC] GDSC2 4.6193 6.0235 1.8703 0.1737
LS123 GDSC2 4.8308 6.6034 1.7449 0.3534
C2BBe1 GDSC2 4.9574 6.9735 1.6603 0.5067
⏷ Show the Full List of 43 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC2 4.8078 6.8111 1.6606 0.58
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hep 3B2.1-7 GDSC2 2.7855 5.3604 1.1696 6.0522
JHH-6 GDSC2 2.8986 4.6723 1.5857 3.2273
SNU-398 GDSC2 3.0333 6.5839 0.7508 8.0391
JHH-2 GDSC2 3.1418 5.9162 1.1536 5.3234
HuH-1 GDSC2 3.1797 5.3595 1.4447 3.4994
Huh-7 GDSC2 3.2731 10.2698 -0.8898 16.712
SNU-423 GDSC2 3.2861 5.6706 1.3667 3.7517
Hep-G2/C3A GDSC2 3.4022 5.3521 1.5843 2.3092
JHH-4 GDSC2 3.4465 5.9411 1.3416 3.5977
JHH-1 GDSC2 3.595 7.4642 0.7188 6.9614
SK-HEP-1 GDSC2 4.1308 5.4157 1.9035 0.2603
JHH-7 GDSC2 4.213 5.7504 1.8138 0.4556
HLE GDSC2 4.499 6.4139 1.6827 0.6913
SNU-387 GDSC2 4.5021 8.8364 0.6524 5.6204
SNU-449 GDSC2 5.0579 6.9607 1.7035 0.3613
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 181 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HARA [Human squamous cell lung carcinoma] GDSC2 -1.3839 1.0041 -1.4534 37.5082
NCI-H322M GDSC2 0.4285 3.2323 -0.0487 21.5948
NCI-H64 GDSC2 0.6151 4.2876 -0.2917 22.1687
LC-1/sq GDSC2 0.6705 6.8715 -1.4422 27.6613
Calu-6 GDSC2 0.6845 3.1808 0.2443 18.8457
EPLC-272H GDSC2 0.6926 5.3724 -0.7085 24.0942
NCI-H1755 GDSC2 1.1107 3.4333 0.5904 15.0807
LB647-SCLC GDSC2 1.4324 4.6214 0.367 15.2037
NCI-H2122 GDSC2 1.4618 6.8177 -0.6776 21.0727
NCI-H1703 GDSC2 1.47 4.8938 0.2717 15.6454
CPC-N GDSC2 1.4991 4.719 0.3837 14.8649
NCI-H2461 GDSC2 1.5543 7.2492 -0.8074 21.4265
IST-SL1 GDSC2 1.6121 5.5468 0.0855 16.2661
SK-MES-1 GDSC2 2.0465 5.306 0.5946 11.7429
A-427 GDSC2 2.1815 5.7731 0.4779 12.0497
NCI-H209 GDSC2 2.2875 6.4811 0.2135 13.3446
HCC33 GDSC2 2.373 6.9016 0.0745 13.922
NCI-H1648 GDSC2 2.4117 4.2785 1.4174 5.471
CAL-12T GDSC2 2.4383 6.1762 0.4909 11.2137
NCI-H2171 GDSC2 2.4606 4.7363 1.2282 6.5316
COR-L311 GDSC2 2.4839 4.2166 1.5059 4.7143
NCI-H1568 GDSC2 2.4976 6.3037 0.4755 11.1398
RERF-LC-MS GDSC2 2.5433 6.2562 0.5361 10.6387
Lu-135 GDSC2 2.5593 5.2277 1.0619 7.3114
IST-SL2 GDSC2 2.5902 5.3979 1.0014 7.6087
NCI-H460 GDSC2 2.5982 6.3218 0.5473 10.418
NCI-H2196 GDSC2 2.6067 5.4319 0.9974 7.5895
BEN GDSC2 2.6088 6.1681 0.6324 9.8627
Lu-65 GDSC2 2.6366 4.6183 1.4242 4.8319
NCI-H847 GDSC2 2.6412 8.3579 -0.4343 16.0479
NCI-H2795 GDSC2 2.6663 8.6079 -0.5389 16.5434
NCI-H524 GDSC2 2.6741 4.7777 1.3738 5.0533
PC-14 GDSC2 2.678 6.8589 0.3429 11.4483
RERF-LC-Sq1 GDSC2 2.6795 5.8198 0.8613 8.2487
COR-L303 GDSC2 2.6819 11.2644 -1.853 22.7119
SBC-5 GDSC2 2.6839 4.2473 1.6417 3.3615
NCI-H647 GDSC2 2.7037 6.3307 0.6261 9.6459
COR-L23 GDSC2 2.7455 6.8414 0.4047 10.891
SK-LU-1 GDSC2 2.7737 7.2276 0.2346 11.8404
NCI-H2227 GDSC2 2.797 7.0483 0.342 11.1332
NCI-H250 GDSC2 2.8035 6.5217 0.6086 9.4904
COR-L321 GDSC2 2.8193 6.8265 0.4695 10.3012
NCI-H1341 GDSC2 2.8203 7.8049 -0.0161 13.191
NCI-H345 GDSC2 2.8208 4.249 1.7357 2.487
NCI-H748 GDSC2 2.8766 7.8637 -0.0014 12.9541
NCI-H2085 GDSC2 2.8957 5.8272 1.0215 6.7036
NCI-H2172 GDSC2 2.9047 4.5396 1.653 2.8103
NCI-H1793 GDSC2 2.9073 5.8903 0.999 6.8144
NCI-H2110 GDSC2 2.981 7.6317 0.1943 11.5321
NCI-H292 GDSC2 2.9882 7.1384 0.4439 10.0205
NCI-H740 GDSC2 2.9928 9.3036 -0.6268 16.1065
NCI-H727 GDSC2 3.0253 5.861 1.0989 5.9191
NCI-H2405 GDSC2 3.0366 6.6405 0.7255 8.1859
NCI-H1436 GDSC2 3.0625 7.0715 0.5326 9.2979
LCLC-103H GDSC2 3.0679 4.6792 1.6918 2.2711
NCI-H1836 GDSC2 3.0894 6.2748 0.9429 6.7281
NCI-H838 GDSC2 3.096 8.3273 -0.0626 12.7298
NCI-H1993 GDSC2 3.0998 5.3853 1.3799 4.0453
COR-L88 GDSC2 3.1033 5.1585 1.49 3.3812
NCI-H1781 GDSC2 3.1102 6.705 0.7476 7.8737
LXF 289 GDSC2 3.1389 6.3218 0.9552 6.5388
NCI-H650 GDSC2 3.1425 6.1838 1.0247 6.1066
NCI-H211 GDSC2 3.1432 6.0304 1.0995 5.6495
COR-L32 GDSC2 3.1699 5.7323 1.2612 4.613
HCC827 GDSC2 3.1819 8.7241 -0.1937 13.2519
NCI-H720 GDSC2 3.1863 9.0855 -0.3693 14.2129
NCI-H1581 GDSC2 3.1989 6.1403 1.0849 5.6156
DMS 273 GDSC2 3.2179 7.7996 0.2892 10.3739
NCI-H146 GDSC2 3.2226 9.5696 -0.5814 15.2582
NCI-H1651 GDSC2 3.225 6.8094 0.779 7.4143
Lu-139 GDSC2 3.2502 5.3649 1.487 3.1185
NCI-H510A GDSC2 3.2522 7.3835 0.5183 8.9251
Lu-99A GDSC2 3.256 5.4198 1.465 3.235
NCI-H1876 GDSC2 3.2614 14.5138 -3.0098 25.3492
NCI-H2081 GDSC2 3.2616 8.0576 0.1945 10.8242
VMRC-LCD GDSC2 3.2637 6.7678 0.8265 7.0382
NCI-H1734 GDSC2 3.2793 7.8565 0.3062 10.1239
NCI-H596 GDSC2 3.2848 11.3023 -1.3932 19.0795
NCI-H1792 GDSC2 3.2894 6.5642 0.9429 6.2775
DMS 53 GDSC2 3.2998 6.1701 1.1391 5.0744
NCI-H1623 GDSC2 3.3107 7.6517 0.4294 9.318
NCI-H2135 GDSC2 3.3317 6.0548 1.215 4.5571
HOP-62 GDSC2 3.3616 6.2352 1.1491 4.8882
NCI-H1770 GDSC2 3.3892 6.3419 1.1166 5.0253
NCI-H2170 GDSC2 3.3948 6.4208 1.0829 5.2145
HOP-92 GDSC2 3.4132 6.6214 0.9995 5.6733
NCI-H2731 GDSC2 3.4236 8.0052 0.3379 9.5946
RERF-LC-KJ GDSC2 3.4318 8.4066 0.1477 10.6854
NCI-H2444 GDSC2 3.4504 5.3762 1.6011 2.1433
Lu-134-A GDSC2 3.4721 7.239 0.7434 7.0776
NCI-H82 GDSC2 3.4729 9.2229 -0.2226 12.6848
NCI-H1092 GDSC2 3.4788 5.9335 1.365 3.406
NCI-H810 GDSC2 3.5014 5.3137 1.657 1.7759
NCI-H2369 GDSC2 3.5089 6.4679 1.135 4.6801
NCI-H3122 GDSC2 3.5285 6.4052 1.1769 4.3982
NCI-H69 GDSC2 3.5314 6.2858 1.2344 4.0597
NCI-H2869 GDSC2 3.5586 7.3422 0.7526 6.8378
NCI-H2023 GDSC2 3.5901 8.1245 0.3975 8.8648
NCI-H226 GDSC2 3.6132 9.388 -0.2013 12.2289
A-549 GDSC2 3.6187 5.8711 1.4761 2.5572
NCI-H2066 GDSC2 3.6333 6.667 1.1208 4.5271
SHP-77 GDSC2 3.6451 8.2514 0.3744 8.8773
NCI-H1693 GDSC2 3.6567 11.2858 -1.1021 16.7744
NCI-H2141 GDSC2 3.6619 5.869 1.5014 2.357
EBC-1 GDSC2 3.6649 6.145 1.3797 3.0083
LK-2 GDSC2 3.694 7.3259 0.8502 5.9849
NCI-H1975 GDSC2 3.7019 8.6504 0.2209 9.6394
DMS 114 GDSC2 3.7067 5.5664 1.6566 1.5113
NCI-H1869 GDSC2 3.7123 6.066 1.4423 2.5954
SW1271 GDSC2 3.7166 7.2722 0.8902 5.7069
NCI-H3255 GDSC2 3.7209 5.9698 1.4897 2.3319
NCI-H2810 GDSC2 3.7236 7.6866 0.6985 6.8132
NCI-H441 GDSC2 3.7308 6.5846 1.2188 3.7932
NCI-H1105 GDSC2 3.7432 7.1899 0.9459 5.3319
KNS-62 GDSC2 3.7449 9.1763 -0.0039 10.8215
NCI-H1944 GDSC2 3.7694 9.2982 -0.0459 11.001
NCI-H23 GDSC2 3.7753 8.8416 0.1794 9.7138
NCI-H2373 GDSC2 3.7782 7.7809 0.6898 6.753
Lu-165 GDSC2 3.7991 10.4541 -0.5885 13.8636
NCI-H1299 GDSC2 3.8115 8.0073 0.6042 7.1833
NCI-H2087 GDSC2 3.8166 6.3941 1.3553 2.9025
NCI-H196 GDSC2 3.8487 8.4555 0.4153 8.2004
ABC-1 GDSC2 3.851 7.7765 0.7394 6.3202
NCI-H1650 GDSC2 3.8542 6.7394 1.2218 3.5693
NCI-H526 GDSC2 3.8938 5.5478 1.7549 0.8825
NCI-H1435 GDSC2 3.9041 6.7638 1.2399 3.3896
IA-LM GDSC2 3.9348 6.996 1.1529 3.8167
NCI-H520 GDSC2 3.9532 8.2751 0.5703 7.0934
NCI-H1915 GDSC2 3.9716 12.9689 -1.6971 18.6924
COR-L105 GDSC2 4.0133 9.1248 0.2059 9.0497
COR-L279 GDSC2 4.033 5.8223 1.7091 0.9429
NCI-H2818 GDSC2 4.0416 9.4892 0.0504 9.8617
SBC-3 GDSC2 4.0502 6.9797 1.2268 3.2333
NCI-H2030 GDSC2 4.0572 6.3194 1.517 1.757
NCI-H446 GDSC2 4.0649 5.9685 1.6653 1.0913
HCC44 GDSC2 4.0812 8.8041 0.4036 7.7898
NCI-H1155 GDSC2 4.0828 11.3052 -0.8002 14.28
NCI-H290 GDSC2 4.1184 6.2122 1.5917 1.3515
NCI-H2228 GDSC2 4.1722 8.5699 0.5724 6.6564
Calu-3 GDSC2 4.1779 6.5417 1.4844 1.7696
UMC-11 GDSC2 4.1821 6.2308 1.6143 1.1931
NCI-H513 GDSC2 4.1887 9.956 -0.0738 10.2337
NCI-H2803 GDSC2 4.2002 6.4052 1.552 1.4411
COLO 668 GDSC2 4.2223 5.9999 1.7234 0.7402
NCI-H1573 GDSC2 4.2586 6.3231 1.6126 1.13
EMC-BAC-2 GDSC2 4.267 6.5211 1.5365 1.4403
NCI-H2291 GDSC2 4.3059 6.3958 1.6053 1.1175
HCC366 GDSC2 4.3071 11.5214 -0.7468 13.507
NCI-H2722 GDSC2 4.332 6.6841 1.501 1.5287
NCI-H1563 GDSC2 4.3408 6.0986 1.736 0.6191
NCI-H2029 GDSC2 4.364 6.0167 1.7761 0.4839
Ms-1 GDSC2 4.3811 6.1316 1.7402 0.5814
HCC15 GDSC2 4.3951 6.6612 1.5402 1.301
NCI-H2347 GDSC2 4.4529 7.1054 1.386 1.9133
NCI-H1048 GDSC2 4.4614 6.5776 1.6035 0.9952
NCI-H2342 GDSC2 4.4737 7.1879 1.362 2.0002
NCI-H2009 GDSC2 4.533 6.3063 1.7368 0.507
NCI-H1688 GDSC2 4.6112 6.4943 1.6987 0.5753
HCC78 GDSC2 4.6409 6.7998 1.5955 0.8896
NCI-H2595 GDSC2 4.6514 7.3787 1.37 1.7738
LCLC-97TM1 GDSC2 4.6518 8.0663 1.0803 3.1371
NCI-H1838 GDSC2 4.655 6.7919 1.6046 0.8484
NCI-H841 GDSC2 4.6841 6.2889 1.8014 0.2832
NCI-H522 GDSC2 4.7098 8.1956 1.0553 3.185
NCI-H835 GDSC2 4.7194 16.8119 -3.0351 21.9982
NCI-H661 GDSC2 4.73 6.8335 1.6204 0.7467
LC-2/ad GDSC2 4.7557 7.4096 1.4068 1.5164
SW1573 GDSC2 4.8107 7.0424 1.575 0.8433
EMC-BAC-1 GDSC2 4.8322 12.3809 -0.8007 12.6521
LOU-NH91 GDSC2 4.9924 15.0425 -1.9737 17.5352
SBC-1 GDSC2 5.0138 6.6132 1.8084 0.1788
NCI-H2591 GDSC2 5.0252 7.2783 1.5751 0.7119
PaCa-3 GDSC2 5.0367 7.4467 1.5164 0.8893
ChaGo-K-1 GDSC2 5.0449 7.2559 1.5914 0.653
NCI-H358 GDSC2 5.0645 7.238 1.6058 0.6018
EKVX GDSC2 5.1279 7.5234 1.5254 0.8039
DMS 79 GDSC2 5.1327 6.783 1.7925 0.1765
NCI-H1666 GDSC2 5.246 7.198 1.6898 0.3256
NCI-H1355 GDSC2 5.332 8.0366 1.4165 1.0266
NCI-H1437 GDSC2 5.3702 7.1474 1.752 0.1852
NCI-H2804 GDSC2 5.3883 7.6741 1.5739 0.5339
⏷ Show the Full List of 181 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC2 2.4074 6.2578 0.4248 11.709
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-140 GDSC2 0.1914 2.8258 -0.158 23.2431
OE21 GDSC2 0.5865 4.3443 -0.346 22.5854
OE33 GDSC2 0.7975 6.9572 -1.3628 26.8234
TE-10 GDSC2 2.0379 3.9971 1.2373 7.7404
TE-11 GDSC2 2.303 3.5893 1.6724 4.1676
TE-15 GDSC2 2.37 5.2295 0.908 8.8078
KYSE-270 GDSC2 2.6916 8.277 -0.3534 15.4605
TE-8 GDSC2 2.7193 8.2705 -0.328 15.2419
OE19 GDSC2 2.8849 5.3781 1.2338 5.4141
TE-4 GDSC2 3.2296 6.4378 0.9626 6.2898
TE-9 GDSC2 3.2726 5.3906 1.489 3.0661
TE-6 GDSC2 3.3987 5.6403 1.4511 3.0572
EC-GI-10 GDSC2 3.4908 11.6244 -1.3948 18.5539
COLO 680N GDSC2 3.6389 5.8234 1.5087 2.3523
KYSE-150 GDSC2 3.7325 5.8272 1.5583 1.9629
KYSE-450 GDSC2 3.8685 7.1539 1.0409 4.5567
TE-5 GDSC2 3.9288 6.0497 1.5656 1.6789
KYSE-510 GDSC2 4.0059 7.8913 0.7843 5.7661
TE-1 GDSC2 4.113 6.9064 1.2942 2.7884
KYSE-70 GDSC2 4.142 7.2329 1.1661 3.4178
KYSE-520 GDSC2 4.149 8.0726 0.789 5.4785
T.T GDSC2 4.3067 6.0855 1.7266 0.6714
KYSE-410 GDSC2 4.3817 7.6787 1.1028 3.3963
KYSE-180 GDSC2 5.4612 13.5271 -0.9303 12.0295
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ES-2 GDSC2 1.8786 6.5786 -0.1863 16.9695
Caov-4 GDSC2 2.3088 5.3591 0.7923 9.7121
Caov-3 GDSC2 2.6813 6.5312 0.5088 10.4284
OV56 GDSC2 2.688 4.123 1.7053 2.9599
A2780 GDSC2 2.7325 7.8247 -0.0953 13.889
TOV-21G GDSC2 2.9249 7.6511 0.1417 11.9895
TYK-nu GDSC2 3.0143 5.1058 1.4562 3.7651
IGROV-1 GDSC2 3.0561 7.3543 0.3884 10.1838
JHOS-2 GDSC2 3.107 6.3335 0.9268 6.7857
OAW42 GDSC2 3.219 7.974 0.2042 10.8722
OVTOKO GDSC2 3.3182 7.1296 0.6892 7.7441
OC 314 GDSC2 3.4091 6.0707 1.2576 4.1544
EFO-21 GDSC2 3.4427 9.2826 -0.2743 13.0438
JHOS-4 GDSC2 3.4617 11.1676 -1.1907 17.6855
OAW28 GDSC2 3.468 10.6917 -0.9504 16.5114
OV-90 GDSC2 3.643 6.7605 1.0832 4.726
SK-OV-3 GDSC2 3.6884 10.2005 -0.5447 13.8995
OVCAR-3 GDSC2 3.6938 7.711 0.6671 7.0587
RMG-I GDSC2 3.8125 8.5746 0.3337 8.7482
TOV-112D GDSC2 3.8133 11.0297 -0.8602 15.2124
OVCAR-4 GDSC2 4.0609 8.6515 0.4626 7.4953
EFO-27 GDSC2 4.0799 6.7811 1.3309 2.6458
OVK18 GDSC2 4.1038 11.1027 -0.6866 13.6601
OVKATE GDSC2 4.2562 6.1251 1.6897 0.8359
FU-OV-1 GDSC2 4.3024 7.1744 1.2796 2.6044
OVISE GDSC2 4.4092 11.6259 -0.7264 13.1802
Kuramochi GDSC2 4.45 9.3851 0.3671 7.2819
DOV13 GDSC2 4.5271 5.8394 1.9005 0.1475
OVCAR-5 GDSC2 4.6422 7.233 1.4249 1.5478
OVCAR-8 GDSC2 4.843 14.8454 -1.9834 17.8938
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Panc 03.27 GDSC2 0.819 4.6724 -0.2588 21.1672
SW1990 GDSC2 2.6883 6.9921 0.2847 11.772
AsPC-1 GDSC2 2.801 7.1199 0.3095 11.3181
DAN-G GDSC2 2.9071 5.7031 1.0908 6.2465
QGP-1 GDSC2 3.0644 5.1598 1.4638 3.6157
PaTu 8902 GDSC2 3.1827 5.263 1.4919 3.2165
Panc 10.05 GDSC2 3.3212 5.8644 1.2982 4.0864
PL4 GDSC2 3.3434 11.8242 -1.6071 19.8753
Hs 766T GDSC2 3.4294 8.1294 0.2814 9.9126
YAPC GDSC2 3.4398 5.9187 1.3478 3.5738
HuP-T3 GDSC2 3.5344 8.9963 -0.0666 11.6651
MIA PaCa-2 GDSC2 3.6514 12.3463 -1.63 19.1887
Panc 02.03 GDSC2 3.7232 7.7957 0.6463 7.1195
Panc 04.03 GDSC2 3.8278 6.5317 1.3001 3.1831
CFPAC-1 GDSC2 3.8822 10.0717 -0.3422 12.3671
Capan-1 GDSC2 3.8879 5.6671 1.7041 1.0974
BxPC-3 GDSC2 3.9117 6.9539 1.1584 3.825
HuP-T4 GDSC2 4.0976 6.2255 1.5762 1.441
SU.86.86 GDSC2 4.1472 5.7176 1.7992 0.5373
KP-4 GDSC2 4.1735 5.5383 1.8758 0.3085
PSN1 GDSC2 4.2031 7.1763 1.2252 3.0172
SUIT-2 GDSC2 4.2481 11.0908 -0.5796 12.7898
HPAC GDSC2 4.3093 6.3064 1.6423 0.9708
PaTu 8988t GDSC2 4.3791 11.4911 -0.6821 13.0235
Capan-2 GDSC2 4.5229 6.5908 1.6252 0.8697
HPAF-II GDSC2 4.5565 7.1278 1.4271 1.6221
KP-2 GDSC2 4.9056 6.2862 1.8813 0.1024
Panc 08.13 GDSC2 4.9154 6.6322 1.7664 0.2786
KP-3 GDSC2 5.1507 7.4548 1.5603 0.6861
KP-1N GDSC2 5.2312 7.1601 1.6976 0.3147
MZ-PC-1 GDSC2 5.2604 7.3367 1.6461 0.4139
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2452 GDSC2 1.4999 5.8943 -0.1883 18.2501
MSTO-211H GDSC2 2.3869 16.6132 -4.7696 32.1952
MPP 89 GDSC2 3.0004 6.4328 0.8009 7.8113
NCI-H2052 GDSC2 4.3246 9.3783 0.2905 7.9448
NCI-H28 GDSC2 4.5386 9.0242 0.5884 5.907
IST-Mes1 GDSC2 4.9595 12.6793 -0.8578 12.6692
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC GDSC2 3.2995 8.4799 0.0148 11.7724
VCaP GDSC2 3.33 6.5515 0.9768 5.985
22Rv1 GDSC2 3.7071 7.4751 0.7881 6.3221
NCI-H660 GDSC2 4.1012 5.62 1.8169 0.5095
PC-3 GDSC2 4.9522 7.4361 1.4845 1.0565
DU145 GDSC2 5.4818 7.4819 1.6769 0.2796
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC2 5.0357 8.6966 1.0112 2.9866
Cancer Drug Sensitivity Data Curated from 57 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 800 GDSC2 0.5216 4.5257 -0.4927 23.6492
IGR-37 GDSC2 1.8686 4.4271 0.8712 10.5904
IPC-298 GDSC2 1.9148 13.8768 -3.7981 31.2411
RPMI-7951 GDSC2 2.2194 5.802 0.4957 11.8257
COLO 783 GDSC2 2.3592 4.551 1.2383 6.753
WM793 GDSC2 2.5309 8.163 -0.4264 16.3213
SK-MEL-30 GDSC2 2.5637 8.6789 -0.6574 17.4675
LOX-IMVI GDSC2 2.6044 9.6497 -1.1093 19.6268
M14 GDSC2 2.7871 6.5036 0.605 9.5554
WT2-iPS GDSC2 2.9284 6.2335 0.8457 7.711
GAK GDSC2 3.0698 5.947 1.0885 5.8812
A101D GDSC2 3.0757 7.11 0.5234 9.3214
SK-MEL-31 GDSC2 3.0854 6.7283 0.7181 8.1131
451Lu GDSC2 3.1221 5.6786 1.2545 4.7544
MZ-MEL-2 GDSC2 3.1531 7.8319 0.2253 10.9115
CP50-MEL-B GDSC2 3.2124 5.3017 1.4926 3.1563
MZ-MEL-7 GDSC2 3.3288 5.1838 1.6175 2.2448
SK-MEL-1 GDSC2 3.3599 7.3978 0.5883 8.2548
SK-MEL-3 GDSC2 3.3972 5.47 1.5281 2.6273
MeWo GDSC2 3.4672 6.6011 1.045 5.2924
WM1552C GDSC2 3.469 8.2364 0.2576 9.9595
UACC-62 GDSC2 3.4995 7.7869 0.4977 8.4777
G-mel GDSC2 3.5045 6.5126 1.1111 4.8287
DJM-1 GDSC2 3.5601 7.3716 0.7395 6.9121
Hs 938.T GDSC2 3.5602 8.528 0.1805 10.1949
SH-4 GDSC2 3.5836 7.404 0.7399 6.8601
SK-MEL-24 GDSC2 3.5944 5.5879 1.5878 2.0023
CP66-MEL GDSC2 3.6014 7.4106 0.7487 6.7709
A-375 GDSC2 3.6087 6.4498 1.2063 4.0798
RVH-421 GDSC2 3.6146 5.827 1.4934 2.4704
COLO 679 GDSC2 3.6705 8.0651 0.4816 8.1954
SK-MEL-2 GDSC2 3.6788 5.0841 1.8414 0.7265
LB373-MEL-D GDSC2 3.7054 5.9914 1.4715 2.4503
HMV-II GDSC2 3.7059 11.0951 -0.9715 16.0219
HT-144 GDSC2 3.736 6.7709 1.1364 4.2507
G-361 GDSC2 3.8101 7.0181 1.0677 4.5086
WM35 GDSC2 3.8398 9.5242 -0.1061 11.1759
WM115 GDSC2 3.8468 7.8494 0.7023 6.5432
A-388 GDSC2 3.8948 8.2079 0.5639 7.2476
SK-MEL-5 GDSC2 3.8969 8.9558 0.2081 9.2852
UACC-257 GDSC2 3.9034 6.1178 1.5235 1.9128
IGR-1 GDSC2 4.0306 6.4271 1.4576 2.0749
MMAc-SF GDSC2 4.0412 6.1427 1.5829 1.4714
COLO 829 GDSC2 4.1344 11.2234 -0.7237 13.7779
LB2518-MEL GDSC2 4.1652 5.7452 1.7963 0.5356
Hs 940.T GDSC2 4.2289 6.3899 1.5719 1.3264
IST-MEL1 GDSC2 4.2447 7.1176 1.2734 2.7129
Mel Ho GDSC2 4.2553 5.7223 1.8409 0.3604
CHL-1 GDSC2 4.2628 8.1401 0.8271 5.0681
A2058 GDSC2 4.282 5.502 1.929 0.1609
WM278 GDSC2 4.4456 12.2924 -1.0236 14.5528
COLO 792 GDSC2 4.4617 6.5348 1.6203 0.9328
A-431 GDSC2 4.6576 6.7116 1.6363 0.7411
VMRC-MELG GDSC2 4.8531 6.1449 1.9104 0.0791
Mel JuSo GDSC2 4.9809 14.2012 -1.5743 15.8968
SK-MEL-28 GDSC2 5.6622 19.2649 -3.5529 21.6855
EquiPSC Line K2 GDSC2 3.0463 12.0852 -1.9699 22.1775
⏷ Show the Full List of 57 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC2 4.0725 10.6989 -0.5125 12.8348
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYM-1 GDSC2 -0.6736 2.0659 -0.8809 31.0971
STS-0421 GDSC2 -0.2249 3.7439 -0.9431 29.2214
SK-UT-1 GDSC2 0.7109 3.2709 0.2371 18.7753
EW-8 GDSC2 2.2737 5.4147 0.7352 10.1733
G-402 GDSC2 2.3631 6.7312 0.1515 13.4931
SW982 GDSC2 2.502 7.4161 -0.0767 14.4318
TE 441.T GDSC2 2.509 6.2207 0.5261 10.7964
Rh41 GDSC2 2.6996 5.5317 1.0199 7.2047
A-204 GDSC2 2.8388 6.1315 0.8288 8.0394
SW684 GDSC2 2.8649 5.8353 0.9947 6.945
Rh30 GDSC2 2.9182 6.5741 0.67 8.8192
G-401 GDSC2 2.9721 6.0021 0.9915 6.7049
Hs 633.T GDSC2 3.0458 7.0586 0.5264 9.3765
HT-1080 GDSC2 3.0631 6.5743 0.7773 7.8045
GCT GDSC2 3.3176 7.8603 0.3323 9.8778
VA-ES-BJ GDSC2 3.3658 5.244 1.6118 2.2168
RKN GDSC2 3.5419 5.183 1.7346 1.3371
MES-SA GDSC2 3.6585 8.4707 0.2776 9.4095
SK-LMS-1 GDSC2 4.2903 6.4433 1.5791 1.2379
RD GDSC2 4.5378 8.607 0.7776 4.8821
MFH-ino GDSC2 4.5958 6.8976 1.5377 1.1359
SW872 GDSC2 4.6787 6.663 1.6634 0.6432
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-39 GDSC2 -0.4933 0.8158 -0.5038 28.304
MKN45 GDSC2 0.1004 3.5176 -0.5086 25.5392
TGBC11TKB GDSC2 0.1616 4.4484 -0.8282 26.9137
23132/87 GDSC2 0.6308 4.0226 -0.1596 21.3663
SNU-5 GDSC2 1.5264 3.1855 1.1269 10.2497
SK-GT-2 GDSC2 1.7839 4.3637 0.8241 11.1695
OCUM-1 GDSC2 2.0393 5.297 0.5927 11.7771
MKN7 GDSC2 2.0874 6.6266 -0.0288 15.3941
ECC10 GDSC2 2.6012 6.5147 0.4535 10.9857
NUGC-3 GDSC2 2.714 11.3217 -1.8556 22.6318
SCH GDSC2 2.7997 7.4901 0.1244 12.4248
KATO III GDSC2 2.9386 6.8367 0.5556 9.4677
ECC12 GDSC2 2.9737 5.7102 1.1355 5.8131
MKN1 GDSC2 3.2136 7.5686 0.3995 9.7291
GCIY GDSC2 3.2456 6.5004 0.9434 6.371
AGS GDSC2 3.3054 6.6085 0.9326 6.3045
NUGC-4 GDSC2 3.3905 8.445 0.0988 11.0668
Fu97 GDSC2 3.5061 6.8101 0.9714 5.6494
SNU-1 GDSC2 3.6921 6.4414 1.2611 3.6222
TMK-1 GDSC2 3.7274 7.0323 1.0096 4.9931
NCI-N87 GDSC2 3.7971 6.5592 1.2698 3.398
SNU-16 GDSC2 4.0567 5.4118 1.8762 0.3608
MKN28 GDSC2 4.0935 6.8888 1.2911 2.8317
RERF-GC-1B GDSC2 4.3244 7.3206 1.2281 2.8338
HGC-27 GDSC2 4.7491 10.93 -0.1665 9.5955
IM95 GDSC2 4.7715 6.8838 1.6187 0.7266
Hs 746.T GDSC2 4.7882 13.1426 -1.1965 14.6214
SNG-M GDSC2 2.8358 6.486 0.6511 9.1459
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ML-1 [Human leukemia] GDSC2 2.5193 5.9278 0.6808 9.809
CGTH-W-1 GDSC2 2.6727 4.3588 1.579 3.7768
FTC-133 GDSC2 2.8124 6.7257 0.5143 10.0459
HTC-C3 GDSC2 3.1072 6.6675 0.7638 7.782
TT GDSC2 3.1203 6.873 0.6726 8.3064
8305C GDSC2 3.2551 5.9035 1.2364 4.5846
IHH-4 GDSC2 3.2558 7.8219 0.3061 10.1814
WRO GDSC2 3.2669 6.6602 0.8809 6.7019
CAL-62 GDSC2 3.3125 7.5825 0.4645 9.1046
ASH-3 GDSC2 3.532 7.9761 0.4288 8.8112
KMH-2 GDSC2 3.6272 6.9794 0.9704 5.4135
B-CPAP GDSC2 4.0502 5.6923 1.7678 0.708
BHT-101 GDSC2 4.2062 7.8713 0.9159 4.6736
TT2609-C02 GDSC2 4.2704 10.4759 -0.2677 11.1079
K5 GDSC2 4.3232 6.8889 1.4118 1.9409
8505C GDSC2 4.6791 9.4754 0.4665 6.3281
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HO-1-u-1 GDSC2 -0.462 6.9805 -2.5988 36.4691
BICR 10 GDSC2 0.3262 3.3443 -0.201 22.8833
BB49-HNC GDSC2 1.7181 5.1022 0.4012 14.0029
PCI-15A GDSC2 2.0893 3.4507 1.5537 5.5856
SAS GDSC2 2.4364 7.6953 -0.27 15.7271
KON GDSC2 2.4505 6.2791 0.4494 11.4339
HSC-3 GDSC2 2.7315 7.4515 0.09 12.8131
JHU-011 GDSC2 2.9812 5.8858 1.0551 6.291
FaDu GDSC2 3.0594 12.8832 -2.3574 23.6323
LB771-HNC GDSC2 3.2238 6.8409 0.7628 7.5151
SKN-3 GDSC2 3.2395 6.9435 0.724 7.714
HSC-4 GDSC2 3.2576 10.0938 -0.8144 16.3726
Ca9-22 GDSC2 3.2674 7.6828 0.3828 9.6987
PCI-06A GDSC2 3.3024 8.2088 0.1502 10.9828
JHU-022 GDSC2 3.3862 8.9214 -0.1383 12.4276
OSC-19 GDSC2 3.4356 7.3902 0.6452 7.7437
CAL-27 GDSC2 3.4436 6.3722 1.1379 4.7905
BHY GDSC2 3.5609 5.7286 1.5068 2.4809
HSC-2 GDSC2 3.5944 5.3944 1.6717 1.5775
Detroit 562 GDSC2 3.6576 8.7941 0.1201 10.3175
SCC-9 GDSC2 3.7105 6.3136 1.3301 3.2072
BB30-HNC GDSC2 3.7468 10.8214 -0.8067 15.1048
PCI-30 GDSC2 3.7741 10.3499 -0.5556 13.7515
BICR 78 GDSC2 3.876 7.1554 1.0448 4.5218
CAL-33 GDSC2 3.9271 6.5263 1.3587 2.719
BICR 22 GDSC2 3.9385 5.386 1.8376 0.5451
NCI-H3118 GDSC2 3.9465 8.0505 0.6719 6.5224
DOK GDSC2 3.9526 6.2818 1.479 2.0694
JHU-029 GDSC2 4.0428 6.3318 1.5045 1.8332
PCI-04B GDSC2 4.0549 6.3175 1.5167 1.7611
SCC-4 GDSC2 4.1192 10.8156 -0.5363 12.8536
SCC-15 GDSC2 4.1439 6.1456 1.6308 1.1603
KOSC-2 GDSC2 4.1616 8.0572 0.8038 5.3731
BICR 31 GDSC2 4.5879 6.5995 1.6496 0.7423
PE/CA-PJ15 GDSC2 4.6002 7.8658 1.1394 2.9117
SAT [Human HNSCC] GDSC2 4.6302 8.9857 0.6605 5.3626
OSC-20 GDSC2 4.6423 7.2089 1.4348 1.5066
UPCI-SCC-090 GDSC2 4.6876 7.6692 1.2676 2.1937
SCC-25 GDSC2 4.7849 7.4224 1.4152 1.4557
HO-1-N-1 GDSC2 5.0396 6.9905 1.6859 0.408
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HT-1376 GDSC2 3.1225 5.4696 1.3549 4.1485
639V GDSC2 3.2043 5.8103 1.247 4.6261
CAL-29 GDSC2 3.2388 5.4698 1.4308 3.4669
BFTC-905 GDSC2 3.4355 4.9991 1.7579 1.356
RT-112 GDSC2 3.4423 7.8027 0.4498 8.8907
KU-19-19 GDSC2 3.4706 5.9029 1.3741 3.3687
T24 GDSC2 3.5352 9.9524 -0.5354 14.2238
TCCSUP GDSC2 3.8037 7.2178 0.9712 5.0723
5637 GDSC2 3.822 6.1177 1.4802 2.2381
HT-1197 GDSC2 3.8394 6.6859 1.2373 3.5078
RT-4 GDSC2 3.9229 7.742 0.8016 5.8226
SW780 GDSC2 3.9986 6.0639 1.5946 1.4647
SW1710 GDSC2 4.2239 6.2514 1.6254 1.1095
UM-UC-3 GDSC2 4.4016 6.8161 1.4804 1.5477
647V GDSC2 4.7282 9.1757 0.632 5.3556
J82 GDSC2 4.7435 11.3984 -0.3915 10.7789
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NEC8 GDSC2 0.9105 2.6666 0.6754 15.4295
SW954 GDSC2 1.2683 6.0569 -0.4828 20.7151
UWB1.289 GDSC2 1.6587 3.6728 1.0371 10.2933
TC-YIK GDSC2 2.3903 10.0275 -1.474 21.9429
JAR GDSC2 2.4851 8.6285 -0.6965 17.9018
JHOS-3 GDSC2 2.5757 6.3495 0.5155 10.6757
C-4-I GDSC2 2.582 8.3351 -0.4708 16.4162
OVCA420 GDSC2 2.8328 4.8434 1.4574 4.1546
HeLa GDSC2 2.8505 5.7583 1.0219 6.8114
JEG-3 GDSC2 3.0378 6.6282 0.7323 8.141
NCC-IT GDSC2 3.0397 6.3317 0.8792 7.2355
OVCA433 GDSC2 3.0577 6.8387 0.6436 8.6348
LB831-BLC GDSC2 3.2568 5.8833 1.2471 4.5175
PA-1 GDSC2 3.2951 5.7221 1.3484 3.8418
PWR-1E GDSC2 3.4 5.4182 1.5532 2.4832
HEC-1 GDSC2 3.4185 6.3647 1.1251 4.9164
DSH1 GDSC2 3.4944 12.3177 -1.7356 20.0363
SKG-IIIa GDSC2 3.5885 7.2202 0.8309 6.312
OMC-1 [Human cervical carcinoma] GDSC2 3.6081 6.1362 1.3502 3.2659
OVMIU GDSC2 3.6914 7.4922 0.7697 6.4621
OV17R GDSC2 3.7165 8.7648 0.1757 9.8663
C-33 A GDSC2 3.7557 7.3365 0.8851 5.6608
SW962 GDSC2 3.7891 7.5677 0.7978 6.1027
MS751 GDSC2 3.94 8.5731 0.4202 7.9825
SiHa GDSC2 4.0353 12.8987 -1.6153 18.1894
PEO1 GDSC2 4.0968 9.197 0.2273 8.755
ME-180 GDSC2 4.1745 7.8381 0.9121 4.7476
HT-3 GDSC2 4.1883 6.5942 1.4677 1.8357
CAL-39 GDSC2 4.1975 7.7217 0.9787 4.3431
DoTc2 4510 GDSC2 4.2057 6.4373 1.5414 1.4817
BPH-1 GDSC2 4.2349 7.4686 1.1138 3.5552
Ca Ski GDSC2 4.2754 7.241 1.2364 2.8588
HEY GDSC2 4.3005 6.8582 1.4133 1.9602
SW756 GDSC2 4.4399 6.192 1.7417 0.5431
SKN GDSC2 4.4503 6.7383 1.5348 1.2725
NT2-D1 GDSC2 4.6758 6.3831 1.7648 0.3682
KGN GDSC2 4.7313 7.2294 1.4675 1.2942
SiSo GDSC2 4.9673 7.1789 1.5886 0.7041
ACC-OV7 GDSC2 5.4302 8.7589 1.1775 1.8353
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7943).
2 Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening. Mol Cancer Ther. 2011 Apr;10(4):591-602.