Details of the Drug

General Information of Drug (ID: DM6DRFC)

Drug Name
NVP 231
Synonyms NVP231; NVP-231
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 431.6
Logarithm of the Partition Coefficient (xlogp) 5.3
Rotatable Bond Count (rotbonds) 4
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C25H25N3O2S
IUPAC Name
N-(2-benzamido-1,3-benzothiazol-6-yl)adamantane-1-carboxamide
Canonical SMILES
C1C2CC3CC1CC(C2)(C3)C(=O)NC4=CC5=C(C=C4)N=C(S5)NC(=O)C6=CC=CC=C6
InChI
InChI=1S/C25H25N3O2S/c29-22(18-4-2-1-3-5-18)28-24-27-20-7-6-19(11-21(20)31-24)26-23(30)25-12-15-8-16(13-25)10-17(9-15)14-25/h1-7,11,15-17H,8-10,12-14H2,(H,26,30)(H,27,28,29)
InChIKey
MVSSJPGNLQPWSW-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
4096211
CAS Number
362003-83-6
TTD ID
D0S9JG
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Ceramide kinase (CERK) TT9XRNV CERK1_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 143 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JK1 CTRP2 1.9946 4.9969 1.8604 27.4353
MEC1 CTRP2 2.4661 3.9928 2.4581 23.8657
JM1 CTRP2 2.1746 3.7792 2.1673 25.8056
MOLM-16 CTRP2 -1.4567 5.1652 -1.9195 49.9773
NB4 CTRP2 -0.7465 0.6177 -0.7465 45.2419
F-36P CTRP2 -0.6148 3.6483 -0.7363 44.6023
SUP-M2 CTRP2 -0.5559 1.9107 -0.5621 43.9886
ALL-SIL CTRP2 -0.4226 0.7111 -0.4226 43.0839
KE-97 CTRP2 -0.3334 3.5773 -0.4296 42.7221
Jurkat CTRP2 -0.3179 1.5155 -0.3187 42.3892
Peer CTRP2 -0.2903 2.8827 -0.3258 42.2978
EoL-1 CTRP2 -0.2241 1.4106 -0.2244 41.7627
JVM-3 CTRP2 -0.2237 2.1167 -0.2296 41.7768
MOLM-13 CTRP2 -0.1795 3.8918 -0.304 41.779
SUP-T1 CTRP2 -0.1656 5.2073 -0.5239 42.1692
RS4;11 CTRP2 -0.1049 3.3697 -0.1684 41.1424
KMS-21-BM CTRP2 -0.1024 2.7398 -0.1245 41.0158
KMS-12-BM CTRP2 -0.0623 3.4897 -0.1346 40.8836
NU-DUL-1 CTRP2 -0.0547 1.5366 -0.0551 40.6344
KMS-34 CTRP2 0.0125 1.541 0.0123 40.1862
HT CTRP2 0.0301 3.161 -0.0112 40.1897
Karpas-299 CTRP2 0.0334 5.7415 -0.4354 41.1444
AML-193 CTRP2 0.087 4.0845 -0.0457 40.056
DEL CTRP2 0.0932 1.4738 0.0931 39.6478
KM-H2 CTRP2 0.1501 3.7007 0.068 39.5077
Pfeiffer CTRP2 0.1901 2.1655 0.1874 39.0108
SU-DHL-1 CTRP2 0.2213 3.8189 0.1304 39.0612
THP-1 CTRP2 0.231 3.9733 0.1224 39.046
SUP-T11 CTRP2 0.246 3.3963 0.1966 38.7801
RPMI-8402 CTRP2 0.3006 2.703 0.2892 38.3026
MOLT-3 CTRP2 0.3251 1.7676 0.3248 38.1038
MOLT-16 CTRP2 0.3461 1.8896 0.3456 37.9645
MOLM-6 CTRP2 0.3717 3.6741 0.3042 37.9998
SKM-1 CTRP2 0.38 1.1818 0.38 37.737
PL21 CTRP2 0.4437 2.0104 0.4432 37.3143
OCI-AML-2 CTRP2 0.4757 3.5603 0.4235 37.2637
U-937 CTRP2 0.4958 2.6611 0.4887 36.9887
GA-10 CTRP2 0.6236 2.2237 0.6227 36.1173
L-540 CTRP2 0.6247 6.2196 0.081 37.6265
EM-2 CTRP2 0.6422 5.4918 0.29 37.0224
BV-173 CTRP2 0.6452 1.8116 0.6452 35.9704
Granta-519 CTRP2 0.6833 3.2847 0.658 35.799
Reh CTRP2 0.7638 2.7139 0.7592 35.1956
P31/FUJ CTRP2 0.7837 4.3267 0.6647 35.4259
KMS-11 CTRP2 0.823 2.3886 0.8221 34.7887
CML-T1 CTRP2 0.9026 3.2045 0.8872 34.3064
CMK CTRP2 0.954 4.5383 0.816 34.3575
697 CTRP2 1.01 2.547 1.0089 33.5435
NU-DHL-1 CTRP2 1.0166 3.5685 0.9864 33.5956
PF-382 CTRP2 1.0571 4.3352 0.9552 33.5592
M-07e CTRP2 1.0943 4.4095 0.9849 33.3366
NALM-6 CTRP2 1.1152 2.4413 1.1148 32.8405
KYO-1 CTRP2 1.1675 3.4211 1.1499 32.5491
MOLT-13 CTRP2 1.1779 2.8867 1.175 32.431
EB1 CTRP2 1.2077 4.8367 1.0399 32.7728
RPMI-8226 CTRP2 1.2255 2.9869 1.2215 32.1175
OCI-Ly3 CTRP2 1.2323 2.3099 1.2322 32.0592
KMS-27 CTRP2 1.2611 2.6493 1.2605 31.8691
P12-Ichikawa CTRP2 1.2698 3.3587 1.2574 31.8504
WSU-DLCL2 CTRP2 1.3082 2.7142 1.3074 31.5558
KCL-22 CTRP2 1.3112 7.9714 0.2491 34.7104
L-428 CTRP2 1.3197 4.0893 1.2617 31.6696
U266B1 CTRP2 1.3298 4.1032 1.2709 31.6052
RCH-ACV CTRP2 1.3496 4.0628 1.2957 31.457
SEM CTRP2 1.423 3.9263 1.3842 30.9179
Namalwa CTRP2 1.4893 3.6139 1.4721 30.4042
CA46 CTRP2 1.5199 4.8476 1.3744 30.6295
KO52 CTRP2 1.53 4.557 1.4297 30.4113
KE-37 CTRP2 1.5372 2.8585 1.5366 30.0296
OPM-2 CTRP2 1.554 2.5751 1.554 29.9157
HDLM-2 CTRP2 1.5785 5.646 1.2734 30.769
EJM CTRP2 1.6015 4.0393 1.5618 29.7323
Ri-1 CTRP2 1.61 4.1263 1.5633 29.6991
AMO1 CTRP2 1.6105 2.7739 1.6103 29.5398
SU-DHL-6 CTRP2 1.6174 4.688 1.5044 29.8724
A3/Kawakami CTRP2 1.6229 3.0308 1.6216 29.4612
DND-41 CTRP2 1.6431 4.5556 1.5506 29.6324
KMS-28BM CTRP2 1.6444 4.0212 1.608 29.4352
HPB-ALL CTRP2 1.6762 4.9777 1.5204 29.6257
JURL-MK1 CTRP2 1.7354 4.3395 1.6745 28.9118
OCI-Ly19 CTRP2 1.762 2.9928 1.7614 28.532
DB CTRP2 1.7816 4.184 1.7382 28.5451
Kasumi-2 CTRP2 1.8014 3.1829 1.7999 28.2724
BL-70 CTRP2 1.8043 2.6935 1.8043 28.2481
OCI-AML-3 CTRP2 1.8229 2.6907 1.8229 28.124
A4/Fukuda CTRP2 1.8301 3.2898 1.8278 28.0838
ST486 CTRP2 1.8448 2.9614 1.8446 27.979
RPMI-6666 CTRP2 1.8528 3.0741 1.8522 27.9268
JJN-3 CTRP2 1.8686 3.6595 1.859 27.8517
HuT 78 CTRP2 1.8896 4.6109 1.806 27.9618
Raji CTRP2 1.9974 4.9089 1.878 27.3662
Hs 611.T CTRP2 2.0158 3.6959 2.008 26.8653
LP-1 CTRP2 2.0276 4.5693 1.9579 26.9955
MJ CTRP2 2.0305 4.8868 1.917 27.1257
Mino CTRP2 2.0415 2.6884 2.0415 26.6676
TALL-1 [Human adult T-ALL] CTRP2 2.0798 8.8903 0.7083 30.9055
SIG-M5 CTRP2 2.1574 3.0463 2.1573 25.8959
GDM-1 CTRP2 2.1689 5.0005 2.0474 26.2317
SUP-HD1 CTRP2 2.1946 4.3552 2.1562 25.7769
Mono-Mac-1 CTRP2 2.2044 5.0132 2.0835 25.9935
TF-1 CTRP2 2.2511 3.727 2.2463 25.2875
SR CTRP2 2.2591 4.9133 2.1582 25.5603
HEL CTRP2 2.2816 6.7659 1.7205 27.0107
Karpas-422 CTRP2 2.291 3.5191 2.2896 25.0105
OCI-AML-5 CTRP2 2.3021 3.7917 2.2967 24.9498
HuNS1 CTRP2 2.3183 3.9055 2.31 24.8513
Daudi CTRP2 2.3297 3.5219 2.3285 24.7517
SUP-B15 CTRP2 2.3303 3.4495 2.3296 24.7461
HH [Human lymphoma] CTRP2 2.3472 5.8875 2.0513 25.6528
MOTN-1 CTRP2 2.376 4.0872 2.3621 24.4861
Ku812 CTRP2 2.3958 8.3971 1.2416 28.2736
K-562 CTRP2 2.4409 3.9477 2.4338 24.0309
Ci-1 CTRP2 2.4529 3.2889 2.4529 23.9272
OCI-M1 CTRP2 2.5249 5.9442 2.2304 24.4683
JeKo-1 CTRP2 2.5714 4.9354 2.4893 23.4164
RL CTRP2 2.6456 4.3438 2.6268 22.7063
MOLP-8 CTRP2 2.663 5.1921 2.5471 22.9227
KMS-20 CTRP2 2.6749 6.7452 2.1545 24.28
LAMA-84 CTRP2 2.677 9.8703 0.911 28.4868
HL-60 CTRP2 2.6995 4.0262 2.6948 22.3
Kasumi-1 CTRP2 2.7854 6.2478 2.4302 22.9558
HEL 92.1.7 CTRP2 2.8068 8.023 1.8263 25.0597
SET-2 CTRP2 2.9312 4.8838 2.8792 20.9164
SU-DHL-10 CTRP2 2.9725 4.8784 2.9236 20.6308
SU-DHL-8 CTRP2 3.0216 6.3529 2.6564 21.4241
MM1.S CTRP2 3.0596 5.2101 2.971 20.1871
MOLP-2 CTRP2 3.3533 6.4223 2.9962 19.1926
HD-MY-Z CTRP2 3.3774 7.3981 2.6778 20.3056
SK-MM-2 CTRP2 3.5036 16.6553 -1.5032 32.3156
L-363 CTRP2 3.6403 4.3568 3.6399 16.0178
KMS-18 CTRP2 3.9218 8.1244 2.9532 17.7565
MHH-CALL-3 CTRP2 3.9736 6.71 3.5732 15.2364
NOMO-1 CTRP2 4.1259 8.3024 3.0852 16.7038
SU-DHL-4 CTRP2 4.1919 6.3689 3.9257 13.2877
MC116 CTRP2 4.612 5.2634 4.6073 9.5588
MHH-CALL-4 CTRP2 4.6852 7.5869 3.9732 11.7425
OCI-Ly10 CTRP2 4.8998 6.8542 4.5086 9.0707
Toledo CTRP2 5.7207 8.9217 4.3278 7.8652
Karpas-620 CTRP2 5.7357 9.933 3.8372 9.8852
P3HR-1 CTRP2 6.1826 8.6902 4.8348 4.8238
L-1236 CTRP2 6.1964 20.0768 -0.8455 25.0145
REC-1 CTRP2 6.6463 12.3764 3.3649 10.1098
ME1 CTRP2 7.2112 17.9005 1.0585 17.6659
⏷ Show the Full List of 143 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE15 CTRP2 2.7095 6.0818 2.3946 23.3151
TE8 CTRP2 3.4664 7.4144 2.7665 19.7203
OE21 CTRP2 1.9348 4.7007 1.8421 27.6918
TE-11 CTRP2 2.4882 6.0836 2.1527 24.8567
TE-5 CTRP2 2.6357 5.258 2.5057 23.1536
TE-10 CTRP2 2.8296 7.0354 2.2229 23.5709
TE-9 CTRP2 2.9744 5.9883 2.7092 21.3775
TE-6 CTRP2 3.0486 6.675 2.5834 21.6093
KYSE-410 CTRP2 3.1915 4.9949 3.1422 19.173
KYSE-510 CTRP2 3.2564 5.6348 3.1031 19.1027
KYSE-70 CTRP2 3.3928 5.7913 3.2156 18.2797
TE-4 CTRP2 3.4735 6.036 3.241 17.9403
EC-GI-10 CTRP2 3.7328 8.3956 2.6408 19.4649
KYSE-30 CTRP2 3.8386 6.6819 3.4372 16.1352
COLO 680N CTRP2 4.0172 8.664 2.8134 18.0483
TE-14 CTRP2 4.2485 6.9115 3.7944 13.6179
KYSE-520 CTRP2 4.4535 8.2877 3.4242 14.5204
KYSE-180 CTRP2 4.9117 10.7196 2.7067 16.2884
TE-1 CTRP2 5.4598 10.2265 3.4482 12.0772
KYSE-140 CTRP2 5.9863 13.6836 2.1763 16.0466
KYSE-150 CTRP2 6.1513 10.4488 3.9306 8.6749
OE33 CTRP2 6.608 11.279 3.8807 8.0543
KYSE-450 CTRP2 6.8875 12.6055 3.4373 9.3961
OE19 CTRP2 8.2692 15.8315 2.858 9.5069
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 5.5475 9.6651 3.805 10.4129
BxPC-3 CTRP2 1.4218 5.3042 1.1807 31.5941
KP-3 CTRP2 1.6027 7.2476 0.8222 32.1102
KP-4 CTRP2 2.0838 6.8466 1.4791 28.4523
HuP-T4 CTRP2 2.2356 4.4538 2.1902 25.5275
MIA PaCa-2 CTRP2 2.6225 3.944 2.6185 22.8106
PSN1 CTRP2 2.7963 6.3361 2.4159 22.974
Panc 08.13 CTRP2 2.9007 6.4072 2.5081 22.3257
L3.3 CTRP2 3.4142 6.9804 2.8732 19.4692
DAN-G CTRP2 3.4794 6.0634 3.2399 17.9265
Panc 03.27 CTRP2 3.6017 6.6983 3.1752 17.8003
Hs 766T CTRP2 3.705 5.9197 3.5243 16.214
Panc 10.05 CTRP2 4.1973 7.5496 3.4841 14.9548
SU.86.86 CTRP2 4.2844 7.0234 3.7895 13.5359
Capan-2 CTRP2 4.503 9.2489 3.0278 15.9781
Capan-1 CTRP2 4.5271 7.6575 3.78 12.9189
KP-2 CTRP2 4.5659 7.7002 3.8011 12.7346
PaTu 8988s CTRP2 4.5914 8.194 3.6055 13.4477
SW1990 CTRP2 4.6418 8.6259 3.4564 13.9206
Panc 02.03 CTRP2 4.8022 8.4894 3.678 12.633
PaTu 8902 CTRP2 4.9004 7.4153 4.269 10.0112
PaTu 8988t CTRP2 5.0576 9.0545 3.6545 12.1225
TCC-Pan2 CTRP2 5.2794 11.316 2.7467 15.3099
Panc 04.03 CTRP2 5.3056 8.6504 4.084 9.7856
AsPC-1 CTRP2 5.5501 10.423 3.4306 11.9582
SNU-410 CTRP2 5.5545 11.1238 3.0857 13.3605
SUIT-2 CTRP2 5.5827 11.831 2.7579 14.6187
YAPC CTRP2 5.7661 10.9339 3.3641 11.7854
SNU-213 CTRP2 6.1031 7.0684 5.5805 1.8398
CFPAC-1 CTRP2 6.2658 10.9953 3.751 9.2091
HPAF-II CTRP2 6.404 11.4273 3.6464 9.3883
PK-45H CTRP2 6.8089 10.5027 4.4158 5.5027
Panc 05.04 CTRP2 6.8295 17.4872 0.9633 18.6681
QGP-1 CTRP2 6.9453 8.4544 5.4815 1.0914
PK-59 CTRP2 7.8116 14.3379 3.2621 8.6228
HuP-T3 CTRP2 8.0538 19.4128 0.952 16.5687
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 48 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 4.1944 13.2386 0.8092 24.7584
G-361 CTRP2 2.474 5.3678 2.3096 24.3494
IGR-37 CTRP2 2.526 4.7417 2.4662 23.6423
IGR-1 CTRP2 2.6887 5.1207 2.5867 22.7036
A2058 CTRP2 2.7664 4.7671 2.718 22.0017
CJM [Human melanoma] CTRP2 2.7968 5.4664 2.6396 22.1761
RPMI-7951 CTRP2 2.8654 4.3641 2.8527 21.2214
LOX-IMVI CTRP2 2.9409 6.0441 2.6575 21.6651
HMCB CTRP2 2.9583 5.5491 2.7976 21.1133
Mel Ho CTRP2 3.0055 7.1351 2.3771 22.4917
Hs 294T CTRP2 3.4465 6.6064 3.038 18.7628
MeWo CTRP2 3.4983 6.5216 3.1222 18.2994
COLO 792 CTRP2 3.5355 7.723 2.7174 19.7121
MDA-MB-435S CTRP2 3.5465 10.1012 1.686 23.4924
SK-MEL-5 CTRP2 3.6 7.8375 2.7386 19.453
Hs 944.T CTRP2 3.6952 9.7752 1.9844 22.0276
COLO 829 CTRP2 3.9679 10.5883 1.8734 21.7271
HT-144 CTRP2 4.2192 8.0519 3.2912 15.6514
SK-MEL-1 CTRP2 4.3894 10.696 2.2278 19.3699
Hs 940.T CTRP2 4.5604 8.7031 3.34 14.589
Hs 895.T CTRP2 4.575 6.8012 4.1854 11.2111
WM88 CTRP2 4.7604 9.607 3.1056 15.048
Mel JuSo CTRP2 4.7607 6.6931 4.4251 9.776
IPC-298 CTRP2 4.921 9.5026 3.3085 13.8513
COLO 800 CTRP2 5.1839 10.0038 3.3086 13.2527
WM793 CTRP2 5.1926 10.1771 3.2313 13.5486
RVH-421 CTRP2 5.2587 11.3041 2.7342 15.4047
WM115 CTRP2 5.2731 8.9691 3.8983 10.6264
Hs 852.T CTRP2 5.5282 9.5057 3.8667 10.1971
SK-MEL-3 CTRP2 5.618 10.5966 3.4039 11.926
Hs 688(A).T CTRP2 5.6372 9.06 4.1851 8.6375
WM983B CTRP2 5.6517 10.3053 3.5785 11.1347
K029AX CTRP2 5.7956 10.703 3.5047 11.1453
SK-MEL-31 CTRP2 6.1037 10.7293 3.7512 9.5142
UACC-257 CTRP2 6.1386 10.968 3.6606 9.8243
SK-MEL-2 CTRP2 6.1797 9.9411 4.2076 7.4617
UACC-62 CTRP2 6.2176 10.7278 3.8454 8.9058
IGR-39 CTRP2 6.4026 9.8191 4.4467 6.055
A101D CTRP2 6.4044 10.484 4.117 7.4298
A-375 CTRP2 6.5506 15.5375 1.7128 16.647
WM1799 CTRP2 6.6784 16.3817 1.3941 17.5177
SK-MEL-30 CTRP2 6.7047 13.4462 2.8783 11.9639
SK-MEL-24 CTRP2 6.7155 11.2889 3.9583 7.5484
Hs 839.T CTRP2 6.842 10.7603 4.3136 5.8709
WM266-4 CTRP2 6.986 11.7612 3.9277 7.2272
SK-MEL-28 CTRP2 7.0618 7.9714 5.7401 0.2266
WT2-iPS CTRP2 7.9818 14.0409 3.5228 7.3522
Hs 936.T CTRP2 8.728 18.9994 1.6442 13.2142
⏷ Show the Full List of 48 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 CTRP2 2.8527 7.0119 2.2562 23.3819
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MHH-NB-11 CTRP2 0.2886 4.0935 0.1682 38.6988
CHP-126 CTRP2 1.6272 6.2301 1.1718 30.9387
CHP-212 CTRP2 1.9572 5.5924 1.6987 28.109
IMR-32 CTRP2 1.9601 2.791 1.9601 27.2104
NB1 CTRP2 2.2825 4.3493 2.2487 25.1759
SK-N-SH CTRP2 2.2968 5.3775 2.1154 25.5878
NH-6 CTRP2 2.6098 6.7719 2.0749 24.7608
SK-N-AS CTRP2 2.9018 7.0158 2.3078 23.0492
SK-N-DZ CTRP2 2.9087 6.2904 2.5521 22.1426
KP-N-SI9s CTRP2 3.321 6.1755 3.0355 19.1463
SK-N-BE(2) CTRP2 3.4605 9.2987 1.964 22.7281
KP-N-YN CTRP2 7.8602 9.7053 5.4154 0.6093
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-478 CTRP2 2.3623 5.7411 2.1046 25.4182
SNU-1079 CTRP2 3.1336 7.6303 2.3281 22.3006
HuCC-T1 CTRP2 3.3804 5.9157 3.1712 18.4763
SNU-869 CTRP2 4.0932 7.4302 3.4242 15.4694
SNU-1196 CTRP2 4.7694 7.6157 4.0464 11.2342
HuH-28 CTRP2 7.9985 9.4946 5.5534 0.2502
SNU-308 CTRP2 8.1213 9.695 5.5285 0.2556
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-MC CTRP2 1.0068 2.5225 1.0059 33.5644
MHH-ES-1 CTRP2 1.2012 3.0824 1.1953 32.2856
SK-ES-1 CTRP2 2.0115 3.0589 2.0113 26.8683
TC71 CTRP2 2.2159 5.5864 1.9818 26.3086
A-673 CTRP2 2.4728 3.5315 2.4722 23.7963
SaOS-2 CTRP2 2.8654 5.378 2.7317 21.6372
Hs 888.T CTRP2 3.3232 6.755 2.8542 19.8042
MG-63 CTRP2 3.9495 8.4297 2.8486 18.0884
SJSA-1 CTRP2 3.988 6.7801 3.5636 15.2307
HOS CTRP2 4.288 8.1883 3.3012 15.4328
G-292 clone A141B1 CTRP2 4.5847 8.8858 3.2786 14.7751
Hs 822.T CTRP2 5.8383 9.8438 3.9703 9.1207
CAL-78 CTRP2 5.8595 9.8458 3.9875 9.0063
SW1353 CTRP2 5.8625 6.5385 5.6331 2.1151
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 73 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU4475 CTRP2 1.833 2.6761 1.833 28.0566
MDA-MB-468 CTRP2 1.9694 4.2075 1.9328 27.2712
SK-BR-3 CTRP2 2.405 6.025 2.0779 25.3785
Hs 578T CTRP2 2.5286 3.6209 2.5278 23.4256
CAL-51 CTRP2 2.5353 6.0851 2.2036 24.531
CAL-85-1 CTRP2 2.5424 6.8481 1.9763 25.3156
HCC38 CTRP2 2.5489 4.8789 2.4732 23.5441
AU565 CTRP2 2.6701 7.4808 1.8896 25.2389
HCC1954 CTRP2 2.7605 6.1298 2.4369 23.0076
MDA-MB-453 CTRP2 2.7847 8.649 1.5476 26.0945
HCC1806 CTRP2 2.8441 5.6416 2.653 21.9805
BT-20 CTRP2 3.1148 6.7478 2.6309 21.2394
EFM-192A CTRP2 3.2502 6.0613 2.9904 19.5241
HMC-1-8 CTRP2 3.5567 6.791 3.0944 18.2318
MDA-MB-157 CTRP2 3.5994 10.5199 1.5444 23.8469
JIMT-1 CTRP2 3.6317 5.0613 3.6006 16.1787
HCC1500 CTRP2 3.7297 9.4731 2.1572 21.3002
ZR-75-1 CTRP2 3.8026 8.3236 2.744 18.8825
BT-549 CTRP2 3.8567 8.5702 2.6917 18.9398
Hs 578Bst CTRP2 3.9134 9.7023 2.2352 20.5308
HCC1395 CTRP2 4.0741 8.5108 2.9397 17.408
HCC1143 CTRP2 4.3659 10.5984 2.2523 19.3343
BT-474 CTRP2 4.4899 7.2571 3.9121 12.4995
MDA-MB-231 CTRP2 4.6646 11.1186 2.2821 18.5075
HDQ-P1 CTRP2 4.801 7.8884 3.9553 11.5177
UACC-812 CTRP2 4.9713 15.36 0.4646 24.0001
HCC1428 CTRP2 5.3847 9.6457 3.6682 11.3306
HCC1419 CTRP2 5.5051 9.5444 3.8269 10.4124
T-47D CTRP2 5.6526 10.8393 3.3131 12.228
ZR-75-30 CTRP2 5.7493 14.9515 1.3426 19.5213
MDA-MB-361 CTRP2 5.8696 10.8741 3.4824 11.0889
CAL-120 CTRP2 6.0768 9.2724 4.4573 6.6086
MCF-7 CTRP2 6.1423 7.5775 5.3578 2.7025
HCC202 CTRP2 6.3469 11.5422 3.5433 9.9194
CAMA-1 CTRP2 6.3829 8.3158 5.177 3.0427
HCC1937 CTRP2 6.638 15.1056 1.9985 15.451
MDA-MB-415 CTRP2 6.7501 12.6059 3.3316 10.0627
CAL-148 CTRP2 7.4198 22.6897 -1.1617 23.5509
HCC2218 CTRP2 7.4369 11.3241 4.4554 4.4202
KPL-1 CTRP2 7.4691 21.1933 -0.3779 21.4752
BT 416 CTRP2 0.5408 3.424 0.5018 36.7901
BT 231 CTRP2 1.6634 7.5788 0.7711 32.0616
BT 145 CTRP2 1.6717 3.5317 1.6621 29.1635
BT 239 CTRP2 2.1019 5.5012 1.877 27.0338
BT 112 CTRP2 2.6035 5.2773 2.4674 23.3892
BT 245 CTRP2 2.6437 5.7585 2.4071 23.4743
BT164 CTRP2 3.1561 6.4736 2.7654 20.6245
BT147 CTRP2 3.1713 5.9836 2.9253 19.9988
BT 172 CTRP2 3.2678 6.1591 2.9821 19.5006
BT 286 CTRP2 3.4952 7.669 2.6965 19.9031
BT 179 CTRP2 3.5817 7.1057 3.0073 18.4862
BT 504 CTRP2 3.7043 7.7729 2.8747 18.6472
BT 359 CTRP2 3.963 7.8325 3.1205 16.9978
BT 428 CTRP2 4.2609 7.7837 3.4507 14.9151
BT 422 CTRP2 4.3098 9.4084 2.7636 17.4987
BT 224 CTRP2 4.7537 9.4241 3.1871 14.7355
BT 216 CTRP2 4.7619 11.3786 2.2453 18.4205
BT 228 CTRP2 4.8104 9.9342 2.995 15.3745
BT 139 CTRP2 5.048 9.7972 3.2844 13.6571
BT 159 CTRP2 5.1165 13.4619 1.5366 20.2051
BT 440 CTRP2 5.1732 9.7759 3.4107 12.8588
BT 482 CTRP2 5.2186 9.3236 3.6743 11.6734
BT 248 CTRP2 5.2843 10.2369 3.2853 13.126
BT 328 CTRP2 5.3716 8.4956 4.2212 9.0689
BT 131 CTRP2 5.4889 10.1436 3.5153 11.7386
BT 330 CTRP2 5.5816 13.5962 1.8762 17.9884
BT 333 CTRP2 6.0491 11.691 3.2251 11.7922
BT 271 CTRP2 6.3681 11.9386 3.3626 10.6234
BT 232 CTRP2 6.4402 12.8876 2.9468 12.1741
BT 320 CTRP2 6.9892 11.2115 4.1997 6.1063
BT 444 CTRP2 7.1422 16.5632 1.6695 15.7168
BT 498 CTRP2 7.3515 9.8986 5.0669 2.1664
BT 340 CTRP2 8.2321 15.6986 2.8965 9.4149
⏷ Show the Full List of 73 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 1.5175 3.2208 1.513 30.1737
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D283 Med CTRP2 1.5831 4.8637 1.4398 30.2022
SF539 CTRP2 1.7696 4.1957 1.7246 28.6302
LN-18 CTRP2 2.0918 3.7142 2.0848 26.3562
Hs 683 CTRP2 2.6038 3.6887 2.6028 22.925
Daoy CTRP2 2.6278 4.7119 2.5775 22.9315
YH-13 CTRP2 2.6948 4.7938 2.6391 22.5039
SF268 CTRP2 3.2027 7.0189 2.6315 20.9798
Becker CTRP2 3.4728 6.8415 2.9859 18.8795
GaMG CTRP2 3.5298 5.5113 3.4251 17.1116
LN-229 CTRP2 3.5589 5.183 3.5094 16.7262
DK-MG CTRP2 3.5709 6.1126 3.326 17.3375
A-172 CTRP2 3.668 5.6676 3.5432 16.2618
CAS-1 CTRP2 3.723 4.3966 3.7227 15.4667
T98G CTRP2 3.7371 5.9711 3.546 16.0377
SNU-466 CTRP2 3.7382 4.7735 3.7312 15.3875
U-118MG CTRP2 3.7564 6.9028 3.2698 16.9993
42-MG-BA CTRP2 3.7889 7.2567 3.1712 17.2809
SF126 CTRP2 4.0172 6.989 3.5177 15.3215
ONS-76 CTRP2 4.1383 7.5414 3.4257 15.3409
SW1088 CTRP2 4.284 9.4698 2.7095 17.7746
KNS-81 CTRP2 4.5151 7.4967 3.8372 12.725
TM-31 CTRP2 4.6038 8.1668 3.6304 13.3167
KNS-42 CTRP2 4.882 11.0605 2.5121 17.1188
U-251MG CTRP2 4.9034 8.599 3.7251 12.1973
M059K CTRP2 5.1974 9.6649 3.4875 12.4895
CCF-STTG1 CTRP2 5.2505 8.6476 4.0338 10.1185
YKG-1 CTRP2 5.3406 9.5352 3.6826 11.3682
NMC-G1 CTRP2 5.3646 7.8644 4.5203 7.8516
KG-1-C CTRP2 5.3897 9.63 3.6805 11.2692
DBTRG-05MG CTRP2 5.3928 10.1442 3.429 12.3005
KALS-1 CTRP2 5.4085 8.9334 4.0409 9.7335
SW1783 CTRP2 5.4572 9.5012 3.8052 10.6053
GMS-10 CTRP2 5.7954 10.4383 3.6366 10.5987
SNB-75 CTRP2 6.1502 10.1946 4.0568 8.1493
U-87MG ATCC CTRP2 6.1855 7.3103 5.5248 1.9263
8-MG-BA CTRP2 6.1868 11.6842 3.3423 11.0469
GOS-3 CTRP2 6.2912 12.5234 3.0082 12.2066
SNU-1105 CTRP2 6.3609 7.9076 5.3616 2.3138
GB-1 CTRP2 7.5407 12.1496 4.1308 5.5672
SNU-201 CTRP2 8.2477 21.52 0.0572 18.9568
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHUEM-2 CTRP2 0.3515 5.1118 0.0591 38.7394
JHUEM-7 CTRP2 1.9746 3.4229 1.9718 27.1228
HEC-151 CTRP2 2.4131 5.9893 2.0964 25.2886
AN3-CA CTRP2 2.6266 7.3602 1.8874 25.3764
JHUEM-1 CTRP2 2.8166 5.5895 2.6348 22.1306
HEC-50B CTRP2 3.4516 7.9175 2.5498 20.5781
JHUEM-3 CTRP2 3.7014 7.6345 2.9283 18.4506
ESS-1 CTRP2 3.7204 7.4809 3.0102 18.0854
EN CTRP2 3.835 9.9416 2.0465 21.4353
EFE-184 CTRP2 4.0325 7.6401 3.2739 16.2157
HEC-6 CTRP2 4.1803 11.1385 1.8155 21.4044
HEC-108 CTRP2 4.474 9.2773 2.9862 16.2147
MFE-296 CTRP2 4.5852 10.5021 2.5072 17.83
KLE CTRP2 4.6454 8.9278 3.3184 14.4669
HEC-1-A CTRP2 4.7168 9.5977 3.0684 15.3004
RL95-2 CTRP2 4.8656 6.083 4.7472 8.2688
HEC-265 CTRP2 5.0298 7.5022 4.3611 9.313
MFE-319 CTRP2 5.4257 9.7119 3.6726 11.2235
HEC-59 CTRP2 5.5384 12.3416 2.4648 15.8627
HEC-251 CTRP2 6.0867 10.4424 3.8806 9.0074
HEC-1-B CTRP2 6.6767 10.7662 4.1875 6.664
Ishikawa (Heraklio) 02 ER- CTRP2 3.463 5.9781 3.245 17.9581
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UO-31 CTRP2 1.6126 3.96 1.5794 29.6363
KMRC-3 CTRP2 2.2741 5.0399 2.1541 25.5262
786-O CTRP2 2.6017 4.2207 2.588 22.9815
TUHR4TKB CTRP2 2.8386 5.6637 2.642 22.0364
CAL-54 CTRP2 2.9873 4.8781 2.9393 20.5288
BFTC-909 CTRP2 3.4872 5.1998 3.4307 17.2278
KMRC-1 CTRP2 3.7929 5.6279 3.6871 15.3634
KMRC-20 CTRP2 3.8426 5.8032 3.7028 15.1525
Caki-2 CTRP2 3.9941 7.3118 3.3674 15.9603
KMRC-2 CTRP2 4.2803 8.1154 3.3256 15.3564
VMRC-RCW CTRP2 4.5122 8.7023 3.2927 14.898
VMRC-RCZ CTRP2 4.8651 9.3252 3.3411 13.8497
769-P CTRP2 4.9783 8.6096 3.7925 11.7438
A-498 CTRP2 4.9796 8.6571 3.7711 11.8282
OS-RC-2 CTRP2 5.8514 10.9611 3.4234 11.3688
ACHN CTRP2 5.9474 9.6854 4.1424 8.1821
Caki-1 CTRP2 5.997 10.245 3.9045 9.081
RCC10RGB CTRP2 6.7836 10.8375 4.2326 6.3001
TUHR10TKB CTRP2 7.659 12.73 3.9326 6.1899
SNU-1272 CTRP2 8.1733 9.4494 5.6344 0.0978
TUHR14TKB CTRP2 9.1557 11.1991 5.3835 0.2146
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 47 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW48 CTRP2 0.2159 2.0432 0.2144 38.8354
HT115 CTRP2 0.8891 2.0662 0.889 34.3455
LoVo CTRP2 0.9422 9.2765 -0.6485 38.0524
NCI-H747 CTRP2 1.5598 9.6455 -0.1496 34.8615
T84 CTRP2 1.6069 4.2156 1.5517 29.7481
SNU-61 CTRP2 1.6662 5.2743 1.4524 29.8865
SW948 CTRP2 1.6938 3.0933 1.6924 28.9889
CCK-81 CTRP2 1.7014 10.5404 -0.3843 34.9453
GP2d CTRP2 1.9911 5.5308 1.7498 27.8254
CW-2 CTRP2 1.9919 7.7539 1.0604 30.1097
SK-CO-1 CTRP2 2.0614 5.607 1.8088 27.3983
LS1034 CTRP2 2.3707 4.0927 2.3564 24.5222
CL-11 CTRP2 2.4022 5.5592 2.1907 24.9916
SNU-1033 CTRP2 2.4298 6.3144 2.0228 25.4961
NCI-H508 CTRP2 2.5853 5.3147 2.4407 23.5398
SNU-C1 CTRP2 2.6756 8.298 1.5771 26.3129
LS513 CTRP2 2.7032 4.4127 2.6822 22.33
SNU-407 CTRP2 2.7996 5.3864 2.6588 22.1001
KM12 CTRP2 2.8005 6.0162 2.5119 22.6169
SNU-81 CTRP2 3.0557 7.1608 2.4219 22.1807
MDST8 CTRP2 3.1565 7.0184 2.5818 21.298
HCT 15 CTRP2 3.2012 5.8517 2.9919 19.6689
RKO CTRP2 3.2612 6.056 3.0038 19.4422
HCC-56 CTRP2 3.2614 5.4036 3.1551 18.9047
C2BBe1 CTRP2 3.4243 6.2216 3.1347 18.4747
NCI-H716 CTRP2 3.6895 8.1908 2.684 19.4166
SNU-C5 CTRP2 3.7004 10.3532 1.7218 22.9597
OUMS-23 CTRP2 3.812 6.301 3.5335 15.8567
LS180 CTRP2 3.8482 7.7289 3.044 17.6044
LS123 CTRP2 3.8839 8.1241 2.9142 18.0088
COLO 320 CTRP2 3.9956 8.0609 3.0569 17.1576
SW1116 CTRP2 4.1219 10.3839 2.1199 20.4334
SW1417 CTRP2 4.4379 6.4976 4.1494 11.7371
HT-55 CTRP2 4.4511 10.5596 2.3522 18.748
SNU-C4 CTRP2 4.8772 7.7741 4.0839 10.8097
SW620 CTRP2 4.9499 11.2758 2.4687 17.133
COLO 678 CTRP2 4.9797 8.8484 3.6797 12.2009
COLO205 CTRP2 5.2723 6.4518 5.0638 5.9051
RCM-1 [Human ESC] CTRP2 5.5024 8.7907 4.197 8.8785
SNU-C2A CTRP2 5.9717 10.561 3.7252 9.8785
SNU-503 CTRP2 6.0342 9.842 4.1371 8.0347
HT-29 CTRP2 6.2657 9.4065 4.544 5.892
HCT 8 CTRP2 6.3257 9.196 4.6964 5.1458
DLD-1 CTRP2 6.4633 10.445 4.1827 7.0507
COLO201 CTRP2 6.6467 12.3602 3.3733 10.0749
HCT 116 CTRP2 6.6542 8.2833 5.3832 1.799
LS411N CTRP2 6.9201 9.1198 5.1609 2.3246
⏷ Show the Full List of 47 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HLF CTRP2 2.6432 4.4895 2.6143 22.7565
JHH-1 CTRP2 2.6554 4.0936 2.648 22.6026
JHH-4 CTRP2 2.6953 5.7858 2.4567 23.1381
SNU-182 CTRP2 2.8236 6.2119 2.4823 22.6521
Hep-G2 CTRP2 3.4606 5.665 3.3184 17.7042
Li-7 CTRP2 3.5027 5.6139 3.3752 17.372
SNU-449 CTRP2 3.5118 6.0233 3.2862 17.6608
PLC/PRF/5 CTRP2 3.7345 7.6 2.9771 18.1725
SNU-423 CTRP2 4.0857 6.9766 3.5956 14.8324
SNU-761 CTRP2 4.165 7.2841 3.5593 14.7514
JHH-5 CTRP2 4.4182 8.3265 3.371 14.822
HuH-6 CTRP2 4.4293 6.6409 4.0892 11.988
SNU-475 CTRP2 4.7162 7.5327 4.0287 11.4419
HuH-1 CTRP2 5.3357 8.5297 4.171 9.3576
SNU-398 CTRP2 5.3694 12.3232 2.3261 16.7566
JHH-2 CTRP2 5.5775 9.4044 3.961 9.6994
Hep 3B2.1-7 CTRP2 5.8947 10.2798 3.8007 9.7165
JHH-6 CTRP2 6.4074 7.4558 5.6134 1.2191
SK-HEP-1 CTRP2 6.6464 11.6439 3.7291 8.6144
SNU-387 CTRP2 6.9209 11.7969 3.8619 7.6031
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 141 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H446 CTRP2 0.0187 3.6673 -0.0672 40.3846
NCI-H1155 CTRP2 0.4956 2.3918 0.4928 36.9761
NCI-H524 CTRP2 0.7749 9.1491 -0.7751 38.8922
NCI-H1568 CTRP2 0.9228 5.6891 0.548 35.2725
NCI-H211 CTRP2 1.0362 2.7096 1.0341 33.3723
NCI-H23 CTRP2 1.2736 3.6976 1.2448 31.8796
COR-L51 CTRP2 1.2868 3.4357 1.2718 31.7458
DV-90 CTRP2 1.4598 3.973 1.419 30.6794
DMS 454 CTRP2 1.6346 8.7849 0.2809 33.5348
NCI-H841 CTRP2 1.6731 5.6416 1.3775 30.1139
NCI-H358 CTRP2 1.8402 5.7978 1.5212 29.0889
NCI-H810 CTRP2 1.8713 3.2484 1.8697 27.8071
NCI-H69 CTRP2 1.885 5.7025 1.5937 28.6991
Calu-6 CTRP2 1.8983 4.5731 1.8201 27.8855
NCI-H1105 CTRP2 1.9226 9.6531 0.2257 32.7493
NCI-H1341 CTRP2 2.0286 3.0124 2.0285 26.7542
NCI-H526 CTRP2 2.0584 4.1591 2.0293 26.6527
LK2 CTRP2 2.0661 2.9379 2.066 26.5042
NCI-H1734 CTRP2 2.1108 10.5748 0.0208 32.6932
EBC-1 CTRP2 2.1169 5.8658 1.8057 27.2322
NCI-H520 CTRP2 2.1236 5.9428 1.7929 27.2551
ChaGo-K-1 CTRP2 2.1271 7.3074 1.3683 28.6862
NCI-H2081 CTRP2 2.1371 4.1414 2.1122 26.1144
HCC44 CTRP2 2.1379 4.872 2.0345 26.3759
NCI-H1703 CTRP2 2.2215 4.9817 2.107 25.8577
HARA [Human squamous cell lung carcinoma] CTRP2 2.3238 4.3138 2.2945 24.8857
NCI-H1581 CTRP2 2.3269 7.1684 1.6331 27.1718
HCC366 CTRP2 2.4775 5.92 2.185 24.7757
LCLC-97TM1 CTRP2 2.4777 4.7646 2.4122 23.9835
RERF-LC-A1 CTRP2 2.5017 4.6151 2.4545 23.7608
NCI-H2171 CTRP2 2.5274 5.2533 2.3896 23.9019
PC-14 CTRP2 2.5399 6.5744 2.063 25.0159
HCC1588 CTRP2 2.5422 4.6918 2.4891 23.5111
SBC-5 CTRP2 2.5444 6.6016 2.0592 25.0156
Calu-3 CTRP2 2.6927 5.537 2.5116 22.9527
DMS 53 CTRP2 2.701 5.772 2.4663 23.0866
NCI-H661 CTRP2 2.7027 6.0264 2.4025 23.3079
DMS 273 CTRP2 2.7083 5.036 2.6211 22.5218
NCI-H2087 CTRP2 2.709 5.3806 2.5618 22.7255
NCI-H2110 CTRP2 2.7477 5.3824 2.6033 22.4579
HCC2279 CTRP2 2.7842 5.9617 2.5087 22.6783
NCI-H522 CTRP2 2.8409 6.3817 2.4508 22.713
HCC95 CTRP2 2.8427 5.4376 2.6953 21.8361
VMRC-LCD CTRP2 2.8667 7.1162 2.2343 23.4199
NCI-H1184 CTRP2 2.9306 7.8293 2.0343 23.9568
HCC4006 CTRP2 2.9579 9.6389 1.3005 26.4296
NCI-H2009 CTRP2 3.0476 9.3581 1.516 25.4494
Lu-99 CTRP2 3.1265 6.0123 2.8687 20.3392
COLO 668 CTRP2 3.1329 6.1495 2.8377 20.4315
RERF-LC-MS CTRP2 3.1399 5.4046 3.0236 19.7485
HCC1438 CTRP2 3.1774 6.7028 2.7139 20.7497
NCI-H2228 CTRP2 3.2105 10.6417 1.1022 26.3724
DMS 114 CTRP2 3.2787 5.9958 3.0392 19.2612
Lu-65 CTRP2 3.3903 5.6704 3.2408 18.1981
NCI-H1666 CTRP2 3.4566 6.8809 2.9546 19.0429
A-549 CTRP2 3.482 5.5138 3.373 17.4449
NCI-H1650 CTRP2 3.4949 7.2002 2.8789 19.2165
NCI-H1355 CTRP2 3.4965 7.7848 2.6512 20.0706
LOU-NH91 CTRP2 3.5195 7.5629 2.7645 19.5784
NCI-H1944 CTRP2 3.5277 7.0443 2.9721 18.7729
SK-MES-1 CTRP2 3.6346 6.7323 3.199 17.6156
NCI-H1792 CTRP2 3.6415 6.4551 3.2994 17.2236
NCI-H647 CTRP2 3.6569 7.2972 3.0148 18.2452
NCI-H292 CTRP2 3.6685 6.6326 3.27 17.2526
NCI-H1915 CTRP2 3.6762 7.2459 3.0553 18.0374
HCC827 CTRP2 3.7341 9.714 2.0514 21.6799
EKVX CTRP2 3.7376 6.6481 3.3396 16.7925
NCI-H322 CTRP2 3.7448 7.5055 3.0261 17.957
NCI-H2029 CTRP2 3.8326 7.0618 3.2926 16.6967
NCI-H889 CTRP2 3.8986 15.7476 -0.694 29.5938
HCC1195 CTRP2 3.9019 10.2297 1.9779 21.5147
LXF 289 CTRP2 4.0698 8.1994 3.0731 16.898
NCI-H2170 CTRP2 4.105 7.2852 3.4954 15.1625
NCI-H1339 CTRP2 4.1221 7.8259 3.2888 15.9173
NCI-H838 CTRP2 4.1293 7.3877 3.4796 15.1566
NCI-H1651 CTRP2 4.1342 7.5395 3.4223 15.3652
HOP-62 CTRP2 4.1599 9.993 2.3419 19.5022
Sq-1 CTRP2 4.2022 9.4179 2.6532 18.1984
COR-L105 CTRP2 4.3391 8.8444 3.0549 16.277
NCI-H1838 CTRP2 4.3622 9.5149 2.7649 17.3635
NCI-H1694 CTRP2 4.3794 8.8573 3.089 16.0407
NCI-H146 CTRP2 4.5457 8.1757 3.5679 13.7135
EPLC-272H CTRP2 4.5744 9.8597 2.8063 16.6841
SW1271 CTRP2 4.6871 13.1178 1.3213 21.9198
T3M-10 CTRP2 4.7183 8.6618 3.5149 13.4971
SK-LU-1 CTRP2 4.779 9.7487 3.055 15.2074
NCI-H2196 CTRP2 4.8558 8.3958 3.7746 12.1112
KNS-62 CTRP2 4.9465 8.3043 3.9064 11.3563
NCI-H2342 CTRP2 4.9494 10.7208 2.7409 16.0672
NCI-H1869 CTRP2 5.0183 9.86 3.226 13.9625
LUDLU-1 CTRP2 5.1046 7.3125 4.5224 8.4772
NCI-H1373 CTRP2 5.1649 10.4352 3.0789 14.2293
NCI-H2106 CTRP2 5.2298 14.3971 1.1712 21.2019
NCI-H2141 CTRP2 5.3123 10.2585 3.2999 13.0052
NCI-H1693 CTRP2 5.3654 9.4907 3.7272 11.1289
COLO 699 CTRP2 5.3736 10.929 3.0228 14.0001
HCC15 CTRP2 5.3908 11.3657 2.8212 14.773
NCI-H1573 CTRP2 5.4602 7.4985 4.7873 6.5313
NCI-H1092 CTRP2 5.5205 9.8448 3.6917 10.9406
SW1573 CTRP2 5.5624 7.2527 5.0032 5.4053
LC-1/sq-SF CTRP2 5.5689 10.4792 3.4192 11.9658
NCI-H1793 CTRP2 5.5832 10.0967 3.6221 11.097
DMS 79 CTRP2 5.6081 12.2755 2.5582 15.3528
NCI-H1755 CTRP2 5.6245 11.4173 3.0004 13.56
COR-L95 CTRP2 5.6706 10.2946 3.6003 11.005
NCI-H1435 CTRP2 5.7235 10.3167 3.6352 10.7511
NCI-H2444 CTRP2 5.8527 8.9298 4.439 7.1272
NCI-H1395 CTRP2 5.9934 11.0422 3.5028 10.7591
HCC78 CTRP2 6.04 9.8692 4.1284 8.0601
NCI-H2126 CTRP2 6.1125 15.5405 1.353 18.7499
NCI-H460 CTRP2 6.1164 9.388 4.4322 6.6386
NCI-H2405 CTRP2 6.1902 8.3951 4.9883 4.1656
CAL-12T CTRP2 6.223 9.2982 4.5638 5.887
COR-L88 CTRP2 6.2608 9.4345 4.5262 5.9758
NCI-H2122 CTRP2 6.279 9.7664 4.3751 6.5758
NCI-H650 CTRP2 6.3493 8.1418 5.2377 2.8457
NCI-H727 CTRP2 6.5523 11.7004 3.6277 9.1987
RERF-LC-Ad2 CTRP2 6.5948 11.9762 3.5238 9.5509
NCI-H1299 CTRP2 6.752 13.1603 3.0576 11.1652
IA-LM CTRP2 6.7525 11.6542 3.8055 8.1167
NCI-H2085 CTRP2 6.7575 20.1399 -0.4182 22.8601
Calu-1 CTRP2 6.8377 12.5093 3.4469 9.4421
HOP-92 CTRP2 6.85 12.376 3.5223 9.1133
NCI-H2023 CTRP2 6.8655 11.0397 4.1936 6.3278
RERF-LC-Ad1 CTRP2 7.0171 8.3538 5.5641 0.7462
NCI-H1563 CTRP2 7.0434 12.6846 3.5157 8.8162
HCC2935 CTRP2 7.183 11.9539 3.9764 6.7172
NCI-H1975 CTRP2 7.2114 11.627 4.1557 5.945
HCC2108 CTRP2 7.3062 15.0158 2.5619 12.1507
HCC1833 CTRP2 7.3182 12.2739 3.9168 6.7526
LCLC-103H CTRP2 7.3688 11.1082 4.513 4.2839
HCC1171 CTRP2 7.4966 11.4154 4.4513 4.356
BEN CTRP2 7.5626 8.5766 5.716 0.1125
NCI-H1623 CTRP2 7.7095 12.7543 3.9551 6.0296
NCI-H196 CTRP2 7.7642 9.0429 5.6261 0.1968
NCI-H2291 CTRP2 7.7726 21.3095 -0.2001 20.4692
NCI-H2172 CTRP2 8.0623 11.6096 4.7092 2.7098
NCI-H2030 CTRP2 8.3467 13.5461 3.9945 5.0441
NCI-H226 CTRP2 8.5761 17.1291 2.4438 10.6052
NCI-H441 CTRP2 9.2847 18.7304 2.1561 10.6383
Hs 888.Lu CTRP2 4.3234 7.9738 3.4323 14.8234
⏷ Show the Full List of 141 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
H-STS CTRP2 1.2414 3.6722 1.213 32.0927
SYO-1 CTRP2 3.2251 6.5892 2.8033 20.2804
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 4.3712 7.827 3.5457 14.2514
A2780 CTRP2 0.901 3.1947 0.886 34.3155
OV7 CTRP2 0.9932 5.6524 0.6338 34.7715
OC 314 CTRP2 1.4237 2.7358 1.4232 30.7855
Caov-3 CTRP2 2.0514 5.5083 1.8206 27.3894
COV434 CTRP2 2.1165 4.8957 2.0079 26.5364
MCAS CTRP2 2.4245 5.0396 2.3159 24.4857
ONCO-DG-1 CTRP2 2.5165 6.2144 2.1466 24.7908
OAW28 CTRP2 2.6477 6.4798 2.21 24.1638
OAW42 CTRP2 2.6841 5.6118 2.4856 23.0711
OVK18 CTRP2 3.0681 5.4815 2.9308 20.3001
SNU-119 CTRP2 3.1447 7.6619 2.3275 22.2714
TOV-112D CTRP2 3.2839 7.4218 2.5689 20.9786
JHOS-2 CTRP2 3.4408 6.028 3.2075 18.1611
FU-OV-1 CTRP2 3.5797 9.0438 2.1989 21.5438
SNU-8 CTRP2 3.6854 6.9127 3.1897 17.5039
OVCAR-4 CTRP2 3.8009 7.2197 3.1983 17.144
TYK-nu CTRP2 3.8901 7.1575 3.3174 16.4406
OV56 CTRP2 4.0787 7.2382 3.4863 15.2697
COV644 CTRP2 4.2162 7.7252 3.4295 15.1168
HEY A8 CTRP2 4.2189 7.7158 3.4362 15.0836
IGROV-1 CTRP2 4.2326 7.7561 3.4333 15.0587
COV362 CTRP2 4.4095 9.1285 2.9927 16.3478
SK-OV-3 CTRP2 4.5252 9.7511 2.8111 16.7838
SNU-840 CTRP2 4.6396 8.3805 3.5681 13.4767
RMG-I CTRP2 4.6826 14.578 0.5956 24.2599
TOV-21G CTRP2 4.8673 8.7226 3.6314 12.6649
OVCAR-8 CTRP2 4.9256 7.5697 4.2254 10.1204
DOV13 CTRP2 4.9426 11.0889 2.5539 16.8178
EFO-21 CTRP2 5.2358 8.9661 3.865 10.8486
OVCAR-5 CTRP2 5.5064 11.2494 2.981 13.8856
ES2 CTRP2 5.5312 10.2092 3.5203 11.6282
JHOM-1 CTRP2 5.8052 10.1448 3.7916 9.9339
OV-90 CTRP2 6.1669 10.1892 4.0732 8.0492
EFO-27 CTRP2 6.2669 10.7108 3.894 8.6114
JHOC-5 CTRP2 6.2943 14.9184 1.8139 16.7756
OVISE CTRP2 6.3453 9.8164 4.4029 6.3397
OVTOKO CTRP2 6.6909 12.2601 3.4575 9.6531
OVSAHO CTRP2 7.1318 9.8858 4.9367 2.9279
Kuramochi CTRP2 7.8778 11.949 4.4442 3.9007
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Aska-SS CTRP2 6.6463 11.182 3.9583 7.6664
Yamato-SS CTRP2 7.2014 11.2946 4.3098 5.3355
Rh41 CTRP2 1.3781 2.9309 1.3762 31.0938
GCT CTRP2 2.0813 4.517 2.0209 26.6061
TE 617.T CTRP2 2.4138 5.3627 2.2453 24.7645
KYM-1 CTRP2 2.5827 6.8508 2.0191 25.0414
HT-1080 CTRP2 2.6433 3.6223 2.6429 22.66
TE 441.T CTRP2 2.7308 4.8062 2.6758 22.2617
BT-12 CTRP2 2.793 3.2114 2.793 21.6612
TTC-709 CTRP2 2.8131 4.422 2.7955 21.5864
A-204 CTRP2 2.8373 7.0703 2.2189 23.5627
RD CTRP2 2.9363 5.4951 2.7851 21.2264
G-401 CTRP2 3.1306 6.0236 2.8702 20.3215
Hs 729.T CTRP2 3.1933 6.7043 2.7306 20.6419
BT-16 CTRP2 3.6243 6.1309 3.3791 16.9836
Tm87-16 CTRP2 3.6331 6.0863 3.4013 16.8766
G-402 CTRP2 3.665 7.7986 2.8229 18.9533
MES-SA CTRP2 3.7478 8.1036 2.7817 18.8849
SK-LMS-1 CTRP2 4.1231 8.1098 3.167 16.3906
SW982 CTRP2 4.9421 8.265 3.9207 11.309
RKN CTRP2 5.2708 9.8673 3.4553 12.4586
Rh18 CTRP2 5.3555 8.254 4.3235 8.6827
SK-UT-1 CTRP2 5.4732 11.0855 3.0333 13.7444
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 6.8905 9.8484 4.793 3.8337
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H28 CTRP2 1.0539 3.0571 1.0463 33.2725
IST-Mes1 CTRP2 1.6091 6.836 0.9669 31.6469
MSTO-211H CTRP2 2.2275 4.4855 2.1786 25.5933
NCI-H2452 CTRP2 3.8848 6.6053 3.5136 15.7158
NCI-H2052 CTRP2 4.8825 12.2377 1.9331 19.3094
JL-1 CTRP2 5.4029 8.323 4.3345 8.529
MPP 89 CTRP2 5.8415 9.4252 4.1821 8.2271
ACC-MESO-1 CTRP2 6.8787 15.7847 1.8509 15.5447
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC CTRP2 2.8023 5.8907 2.5469 22.4866
DU145 CTRP2 3.1795 6.3271 2.8363 20.2958
VCaP CTRP2 5.1068 8.9931 3.7307 11.6961
22Rv1 CTRP2 5.1872 8.5894 4.0021 10.3948
PaCa-3 CTRP2 5.2991 8.1145 4.3375 8.7556
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-15 CTRP2 1.4083 2.6537 1.408 30.8875
A-253 CTRP2 4.7955 8.9949 3.4324 13.6445
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-620 CTRP2 0.1349 3.8501 0.0352 39.6551
HGC-27 CTRP2 1.1829 6.2146 0.6915 33.932
SNU-16 CTRP2 1.5987 3.0364 1.5972 29.623
23132/87 CTRP2 1.87 3.9589 1.8467 27.8884
IM95 CTRP2 2.3028 4.9942 2.1924 25.3021
ECC10 CTRP2 2.353 7.5561 1.5214 27.473
OCUM-1 CTRP2 2.3672 6.1173 2.0112 25.7306
SNU-5 CTRP2 2.4926 5.6398 2.2708 24.4267
NUGC-3 CTRP2 2.6965 5.9527 2.4154 23.2809
HuG1-N CTRP2 2.821 6.0356 2.5291 22.4924
NUGC-4 CTRP2 2.9528 7.6214 2.1389 23.5143
GSS CTRP2 2.9976 6.3574 2.6289 21.5962
Fu97 CTRP2 3.1278 8.9112 1.7931 24.258
SNU-1 CTRP2 3.1442 5.9756 2.8978 20.1807
Hs 746.T CTRP2 3.1673 5.8023 2.9672 19.8616
SNU-601 CTRP2 3.3565 7.217 2.7242 20.1911
ECC12 CTRP2 3.7326 5.7771 3.5891 15.8978
LMSU CTRP2 3.8895 7.7929 3.0605 17.4286
GSU CTRP2 4.0536 5.1484 4.0356 13.3236
SNU-216 CTRP2 4.0837 6.8668 3.6348 14.6893
MKN74 CTRP2 4.098 7.605 3.357 15.7164
KATO III CTRP2 4.1605 8.6427 2.968 17.0741
SNU-668 CTRP2 4.2805 7.1012 3.7547 13.6804
SH-10-TC CTRP2 4.5128 6.5683 4.2053 11.3117
KE-39 CTRP2 5.9266 13.7034 2.1163 16.3914
MKN1 CTRP2 6.1458 11.2366 3.5323 10.3426
SNU-719 CTRP2 6.1474 14.5885 1.8579 16.9036
AGS CTRP2 6.215 11.8813 3.2669 11.3023
MKN7 CTRP2 6.696 14.2492 2.4716 13.5672
MKN45 CTRP2 7.1834 8.2594 5.6816 0.3042
SNG-M CTRP2 2.9885 5.5188 2.8368 20.8803
SNU-685 CTRP2 4.0185 7.3374 3.383 15.8332
SNU-1077 CTRP2 6.4606 11.8386 3.4864 9.9453
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
B-CPAP CTRP2 2.0297 5.6273 1.7695 27.6345
8305C CTRP2 2.0575 5.5345 1.8213 27.3675
CGTH-W-1 CTRP2 2.2342 4.6509 2.1675 25.6094
SW579 CTRP2 2.4515 3.1553 2.4515 23.9363
CAL-62 CTRP2 2.8849 7.3533 2.1676 23.6082
BHT-101 CTRP2 2.9126 5.0039 2.8442 21.0963
FTC-238 CTRP2 2.9598 5.2149 2.8628 20.8806
8505C CTRP2 3.7518 7.3292 3.1034 17.6425
ML-1 [Human leukemia] CTRP2 4.695 7.1128 4.187 10.8756
FTC-133 CTRP2 4.8234 8.9682 3.4721 13.417
TT2609-C02 CTRP2 5.1605 9.2954 3.6341 11.9702
TT CTRP2 5.6737 10.6825 3.4096 11.7874
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-33 CTRP2 1.5729 4.2305 1.5144 29.9855
SCC-25 CTRP2 1.7504 5.0819 1.5816 29.1764
SNU-1076 CTRP2 1.8043 3.7876 1.788 28.3029
CAL-27 CTRP2 2.3132 3.1686 2.3131 24.8582
YD-10B CTRP2 2.3412 3.9853 2.3306 24.7067
BICR 22 CTRP2 2.5789 4.429 2.5518 23.1785
PE/CA-PJ49 CTRP2 2.6023 5.2331 2.4743 23.3689
SNU-1214 CTRP2 2.7908 4.9858 2.7167 21.9272
PE/CA-PJ15 CTRP2 2.8209 6.4136 2.4191 22.8878
PE/CA-PJ34 (clone C12) CTRP2 2.9216 5.7587 2.71 21.5372
BICR 18 CTRP2 3.1097 5.7962 2.9058 20.2585
BICR 31 CTRP2 3.2502 7.6257 2.4539 21.5026
BICR 16 CTRP2 3.3546 6.9273 2.8279 19.8101
BICR 56 CTRP2 3.5071 7.5388 2.761 19.6265
BICR 6 CTRP2 3.572 6.6881 3.1465 17.9936
BHY CTRP2 3.6271 6.3057 3.3306 17.1514
SCC-9 CTRP2 4.3428 7.3561 3.717 13.6562
YD-8 CTRP2 4.3551 6.6412 4.0092 12.5018
HSC-2 CTRP2 4.5307 8.9917 3.1759 15.3193
Detroit 562 CTRP2 5.0148 7.4631 4.3636 9.3409
SNU-899 CTRP2 5.0736 8.8339 3.7763 11.586
FaDu CTRP2 5.3047 9.6692 3.5838 11.8551
PE/CA-PJ41 (clone D2) CTRP2 5.5569 12.2862 2.5085 15.6542
HSC-3 CTRP2 5.6533 7.0586 5.1833 4.4524
SNU-1066 CTRP2 6.177 7.5476 5.4002 2.4624
SCC-4 CTRP2 6.1799 16.5174 0.9204 20.0488
SNU-1041 CTRP2 7.2581 8.7277 5.5284 0.6724
HSC-4 CTRP2 7.4335 15.8432 2.249 13.1157
SNU-46 CTRP2 8.1359 11.9001 4.6212 2.9497
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
5637 CTRP2 0.8997 3.4961 0.8697 34.3732
253J CTRP2 1.9465 7.3473 1.1591 29.9407
RT-112 CTRP2 1.9508 3.4492 1.9474 27.2833
U-BLC1 CTRP2 1.9665 3.934 1.9478 27.2302
CAL-29 CTRP2 2.1956 6.1107 1.8258 26.9141
SCaBER CTRP2 2.3753 5.4223 2.1913 25.0747
UM-UC-1 CTRP2 2.4301 5.3723 2.2611 24.6577
VM-CUB-1 CTRP2 2.694 6.7746 2.1655 24.183
JMSU-1 CTRP2 2.9386 6.0914 2.642 21.7279
RT-4 CTRP2 3.0667 8.0195 2.1026 23.3179
BFTC-905 CTRP2 3.2582 4.7541 3.2358 18.6374
253J-BV CTRP2 3.3073 5.7205 3.1392 18.8162
TCCSUP CTRP2 3.3857 6.485 3.0116 19.0394
647V CTRP2 3.5529 6.3546 3.2348 17.7238
T24 CTRP2 3.6957 8.2109 2.6819 19.408
UM-UC-3 CTRP2 3.9471 5.9275 3.7864 14.5316
SW1710 CTRP2 4.1324 5.5815 4.0635 12.9733
J82 CTRP2 4.4859 7.9502 3.6087 13.7043
HT-1197 CTRP2 4.7244 10.1805 2.7945 16.3748
BC-3C CTRP2 5.3174 6.9512 4.9003 6.4251
HT-1376 CTRP2 6.272 12.107 3.2006 11.4646
KU-19-19 CTRP2 6.5615 12.4161 3.2786 10.6131
KMBC-2 CTRP2 6.6074 12.9134 3.067 11.3859
639V CTRP2 7.1938 8.5663 5.5637 0.6134
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 1.2165 2.5834 1.2159 32.1661

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6668).
2 Targeting ceramide metabolism with a potent and specific ceramide kinase inhibitor. Mol Pharmacol. 2008 Oct;74(4):925-32.