Details of the Drug

General Information of Drug (ID: DM6ECN9)

Drug Name
Aluminium
Synonyms
ALUMINUM; Adom; Aluminio; Metana; AO Al; Al alloy; Alaun [German]; Allbri aluminum paste and powder; Alumina fibre; Aluminium bronze; Aluminium flake; Aluminum alloy; Aluminum dehydrated; Aluminum dust; Aluminum metal; Aluminum powder; Aluminum production; Aluminum pyro powders; Aluminum soluble salts; Aluminum welding fumes; Emanay atomized aluminum powder; Metana aluminum paste; Noral Extra Fine Lining Grade; Noral Ink Grade Aluminum; Noral aluminium; Noral aluminum; Noral ink grade aluminium; A 00; A 95; A 99; A 995; A 999; AA 1099; AA1199; AD 1; AD1M; AO A1; AV00; AV000; Aa1193; Aluminum 27; Aluminum A00; Aluminum hydride [UN2463] [Dangerous when wet]; JISC 3108; JISC 3110; L16; NA9260; Pigment metal 1; ALUMINUM, ATOMIZED; Al(0); Aluminium(0); Aluminium, elementar; Aluminum (dust or fume); Aluminum (fume or dust); Aluminum (metal); Aluminum metal, alkyls; Aluminum metal, pyro powders; Aluminum metal, respirable fraction; Aluminum metal, soluble salts; Aluminum metal, total dust; Aluminum metal, welding fumes; Aluminum powder, coated [UN1309] [Flammable solid]; Aluminum powder, uncoated [UN1396] [Dangerous when wet]; Aluminum, elemental; Aluminum, molten [NA9260] [Class 9]; Aluminum, pyro powders; Aluminum, soluble salts; Aluminum, welding fumes; C-Pigment 1; C-Pigment 1 [German]; Noral non-leafing grade; Aluminum, pyro powders/welding fumes; C.I. 77000; ALUMINUM (SEE ALSO ALUMINUM OXIDE 1344-28-1); ALUMINUM, 99.999%; AQUANAL-plus aluminum (Al) 0.02-0.2 mg/L; AQUANAL(R)-plus aluminum (Al) 0.02-0.2 mg/L; 11008_ALDRICH; 11008_RIEDEL; 11009_ALDRICH; 11009_RIEDEL; 11010_ALDRICH; 11010_RIEDEL; 13Al
Indication
Disease Entry ICD 11 Status REF
Hyperhidrosis EE00 Approved [1]
Therapeutic Class
Antiinflammatory Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski):
0		 Molecular Weight 26.981
Logarithm of the Partition Coefficient Not Available
Rotatable Bond Count 0
Hydrogen Bond Donor Count 0
Hydrogen Bond Acceptor Count 0
Chemical Identifiers
Formula
Al
IUPAC Name
aluminum
Canonical SMILES
[Al]
InChI
InChI=1S/Al
InChIKey
XAGFODPZIPBFFR-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
5359268
ChEBI ID
CHEMBL28984
CAS Number
7429-90-5
UNII
CPD4NFA903
DrugBank ID
DB01370
TTD ID
D0V8TQ

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Sodium pump subunit alpha-1 (ATP1A1) TTWK8D0 AT1A1_HUMAN Binder [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Albumin (ALB) OTVMM513 ALBU_HUMAN Drug Response [3]
Alpha-synuclein (SNCA) OTPWC1MR SYUA_HUMAN Drug Response [4]
Amyloid-beta precursor protein (APP) OTKFD7R4 A4_HUMAN Gene/Protein Processing [5]
Ataxin-3 (ATXN3) OTJVVGKT ATX3_HUMAN Protein Interaction/Cellular Processes [6]
Death domain-associated protein 6 (DAXX) OTX6O7PL DAXX_HUMAN Gene/Protein Processing [5]
Gamma-butyrobetaine dioxygenase (BBOX1) OTKEX4RK BODG_HUMAN Gene/Protein Processing [7]
Gamma-enolase (ENO2) OTRODL0T ENOG_HUMAN Gene/Protein Processing [8]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [9]
Large ribosomal subunit protein eL37 (RPL37) OTB6SDZ1 RL37_HUMAN Gene/Protein Processing [10]
Serotransferrin (TF) OT41PEMS TRFE_HUMAN Regulation of Drug Effects [11]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Hyperhidrosis
ICD Disease Classification EE00
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Sodium pump subunit alpha-1 (ATP1A1) DTT ATP1A1 4.66E-01 1.00E-02 0.06
Sodium pump subunit alpha-1 (ATP1A1) DTT ATP1A1 3.31E-01 -0.03 -0.19
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 Drug information of Cocculin, 2008. eduDrugs.
2 The inhibitory effect of aluminium on the (Na+/K+)ATPase activity of rat brain cortex synaptosomes. J Inorg Biochem. 2003 Sep 15;97(1):143-50.
3 Aluminium-induced impairment of Ca2+ modulatory action on GABA transport in brain cortex nerve terminals. J Inorg Biochem. 2003 Sep 15;97(1):132-42. doi: 10.1016/s0162-0134(03)00256-3.
4 The metal transporter SMF-3/DMT-1 mediates aluminum-induced dopamine neuron degeneration. J Neurochem. 2013 Jan;124(1):147-57. doi: 10.1111/jnc.12072. Epub 2012 Nov 21.
5 Synergistic effects of iron and aluminum on stress-related gene expression in primary human neural cells. J Alzheimers Dis. 2005 Nov;8(2):117-27; discussion 209-15. doi: 10.3233/jad-2005-8204.
6 Destabilization of non-pathological variants of ataxin-3 by metal ions results in aggregation/fibrillogenesis. Int J Biochem Cell Biol. 2007;39(5):966-77. doi: 10.1016/j.biocel.2007.01.012. Epub 2007 Jan 20.
7 The disruption of L-carnitine metabolism by aluminum toxicity and oxidative stress promotes dyslipidemia in human astrocytic and hepatic cells. Toxicol Lett. 2011 Jun 24;203(3):219-26. doi: 10.1016/j.toxlet.2011.03.019. Epub 2011 Mar 23.
8 [Toxic effects of aluminum on human embryonic cerebral neurocytes in vitro studies]. Zhonghua Yu Fang Yi Xue Za Zhi. 2000 Mar;34(2):106-8.
9 A novel approach for a toxicity prediction model of environmental pollutants by using a quantitative structure-activity relationship method based on toxicogenomics. ISRN Toxicol. 2011 Jul 2;2011:515724. doi: 10.5402/2011/515724. Print 2011.
10 Role of microRNA-4516 involved autophagy associated with exposure to fine particulate matter. Oncotarget. 2016 Jul 19;7(29):45385-45397. doi: 10.18632/oncotarget.9978.
11 Comparative binding study of aluminum and chromium to human transferrin. Effect of iron. Biol Trace Elem Res. 1992 Jan-Mar;32:39-46. doi: 10.1007/BF02784585.